Information on EC 3.4.21.54 - gamma-Renin

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The expected taxonomic range for this enzyme is: Mus musculus

EC NUMBER
COMMENTARY hide
3.4.21.54
-
RECOMMENDED NAME
GeneOntology No.
gamma-Renin
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Cleavage of the Leu-/-Leu bond in synthetic tetradecapeptide renin substrate (horse), to produce angiotensin I, but not active on natural angiotensinogen, unlike renin (EC 3.4.23.15). Also hydrolyses Bz-Arg-p-nitroanilide
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
85270-20-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
male
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
benzoyl-Arg 4-nitroanilide + H2O
benzoyl-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
-
Synthetic tetradecapeptide renin substrate + H2O
Angiotensin I
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
it is proposed that gamma-renin in mouse saliva cleaves peptides which are homologous to angiotensinogen and have potent vasoactivity and action in the central nervous system
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-
-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
benzamidine
-
inhibitis cleavage of synthetic tetradecapeptide renin substrate, competitive inhibitor of benzoyl-arginine 4-nitroanilide hydrolysis
diisopropyl fluorophosphate
-
inhibits cleavage of synthetic tetradecapeptide renin substrate, irreversible inhibition of benzoyl-arginine 4-nitroanilide
Pepstatin
-
inhibits cleavage of synthetic tetradecapeptide renin substrate, competitive inhibitor of benzoyl-arginine 4-nitroanilide hydrolysis
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.038
benzoyl-Arg 4-nitroanilide
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7200
-
x * 26000, mouse, SDS-PAGE without reducing agent, x * 7200 + x * 4400, mouse, SDS-PAGE after reduction with 2-mercaptoethanol
26000
-
x * 26000, mouse, SDS-PAGE without reducing agent, x * 7200 + x * 4400, mouse, SDS-PAGE after reduction with 2-mercaptoethanol
additional information
-
nucleotide sequence
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 26000, mouse, SDS-PAGE without reducing agent, x * 7200 + x * 4400, mouse, SDS-PAGE after reduction with 2-mercaptoethanol
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE