Reference on EC 3.4.21.39 - chymase
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Kido, H.; Fukusen, N.; Katunuma, N.
Chymotrypsin- and trypsin-type serine proteases in rat mast cells: properties and functions
Arch. Biochem. Biophys.
239
436-443
1985
Rattus norvegicus
Powers, J.C.; Tanaka, T.; Harper, J.W.; Minematsu, Y.; Barker, L.; Lincoln, D.; Crumley, K.V.; Fraki, J.E.; Schechter, N.M.; Lazarus, G.G.; Nakajima, K.; Nakashino, K.; Neurath, H.; Woodbury, R.G.
Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors
Biochemistry
24
2048-2058
1985
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
Yoshida, N.; Everitt, M.T.; Neurath, H.; Woodbury, R.G.; Powers, J.C.
Substrate specificity of two chymotrypsin-like proteases from rat mast cells. Studies with peptide 4-nitroanilides and comparison with cathepsin G
Biochemistry
19
5799-5804
1980
Rattus norvegicus
Trong, H.L.; Parmelee, D.C.; Walsh, K.A.; Neurath, H.; Woodbury, R.G.
Amino acid sequence of rat mast cell protease I (chymase)
Biochemistry
26
6988-6994
1987
Rattus norvegicus
Sayama, S.; Iozzo, R.V.; Lazarus, G.S.; Schechter, N.M.
Human skin chymotrypsin-like proteinase chymase. Subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans
J. Biol. Chem.
262
6808-6815
1987
Homo sapiens
Kokkonen, J.O.; Vartiainen, M.; Kovanen, P.T.
Low density lipoprotein degradation by secretory granules of rat mast cells. Sequential degradation of apolipoprotein B by granule chymase and carboxypeptidase A
J. Biol. Chem.
261
16067-16072
1986
Rattus norvegicus
Kido, H.; Fukusen, N.; Katunuma, N.
Inhibition of chymase activity by long chain fatty acids
Arch. Biochem. Biophys.
230
610-614
1984
Rattus norvegicus
Fink, E.; Nettelbeck, R.; Fritz, H.
Inhibition of mast cell chymase by eglin c and antileukoprotease (HUSI-I). Indications for potential biological functions of these inhibitors
Biol. Chem. Hoppe-Seyler
367
567-571
1986
Sus scrofa
Katunuma, N.; Fukusen, N.; Kido, H.
Biological functions of serine proteases in the granules of rat mast cells
Adv. Enzyme Regul.
25
241-255
1986
Rattus norvegicus
Johnson, L.A.; Moon, K.E.; Eisenberg, M.
Purification to homogeneity of the human skin chymotryptic proteinase chymase
Anal. Biochem.
155
358-364
1986
Homo sapiens
Fukusen, N.; Kido, H.; Katunuma, N.
Inhibition of chymase activity by phosphoglycerides
Arch. Biochem. Biophys.
237
118-123
1985
Rattus norvegicus
Yurt, R.; Austen, K.F.
Preparative purification of the rat mast cell chymase: characterization and interaction with granule components
J. Exp. Med.
146
1405-1419
1977
Rattus norvegicus
Pereira, P.J.B.; Wang, Z.M.; Rubin, H.; Huber, R.; Bode, W.; Schechter, N.M.; Strobl, S.
The 2.2 A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity
J. Mol. Biol.
286
163-173
1999
Homo sapiens
McGrath, M.E.; Mirzadegan, T.; Schmidt, B.F.
Crystal structure of phenylmethanesulfonyl fluoride-treated human chymase at 1.9 A
Biochemistry
36
14318-14324
1997
Homo sapiens (P23946), Homo sapiens
Takao, K.; Takai, S.; Shiota, N.; Song, K.; Nishimura, K.; Ishihara, T.; Miyazaki, M.
Lack of effect of carbohydrate depletion on some properties of human mast cell chymase
Biochim. Biophys. Acta
1427
74-81
1999
Homo sapiens
Takai, S.; Shiota, N.; Sakaguchi, M.; Muraguchi, H.; Matsumura, E.; Miyazaki, M.
Characterization of chymase from human vascular tissues
Clin. Chim. Acta
265
13-20
1997
Homo sapiens
Pejler, G.; Berg, L.
Regulation of rat mast cell protease 1 activity. Protease inhibition is prevented by heparin proteoglycan
Eur. J. Biochem.
233
192-199
1995
Rattus norvegicus
Sukenaga, Y.; Kido, H.; Neki, A.; Enomoto, M.; Ishida, K.; Takagi, K.; Katunuma, N.
Purification and molecular cloning of chymase from human tonsils
FEBS Lett.
323
119-122
1993
Homo sapiens
Newlands, G.F.Y.; Knox, D.P.; Pirie-Sheperd, S.R.; Miller, H.R.P.
Biochemical and immunological characterization of multiple glycoforms of mouse mast cell protease 1: comparison with an isolated murine serosal mast cell protease (MMCP-4)
Biochem. J.
294
127-135
1993
Mus musculus
Schechter, N.M.; Jordan, L.M.; James, A.M.; Cooperman, B.S.; Wang, Z.; Rubin, H.
Reaction of human chymase with reactive site variants of alpha 1-antichymotrypsin. Modulation of inhibitor versus substrate properties
J. Biol. Chem.
268
23626-23633
1993
Homo sapiens
McGrath, M.E.; Osawa, A.E.; Barnes, M.G.; Clark, J.M.; Mortara, K.D.; Schmidt, B.F.
Production of crystallizable human chymase from a Bacillus subtilis system
FEBS Lett.
413
486-488
1997
Homo sapiens
Waldeck, K.; Lindberg, B.F.; Persson, K.; Andersson, K.E.
Characterization of angiotensin II formation in human isolated bladder by selective inhibitors of ACE and human chymase: a functional and biochemical study
Br. J. Pharmacol.
121
1081-1086
1997
Homo sapiens
Schechter, N.M.; Sprows, J.L.; Schoenberger, O.L.; Lazarus, G.S.; Cooperman, B.S.; Rubin, H.
Reaction of human skin chymotrypsin-like proteinase chymase with plasma proteinase inhibitors
J. Biol. Chem.
264
21308-21315
1989
Homo sapiens
Takai, S.; Shiota, N.; Yamamoto, D.; Okunishi, H.; Miyazaki, M.
Purification and characterization of angiotensin II-generating chymase from hamster cheek pouch
Life Sci.
58
591-597
1996
Mesocricetus auratus
Caughey, G.H.; Raymond, W.W.; Vanderslice, P.
Dog mast cell chymase: molecular cloning and characterization
Biochemistry
29
5166-5171
1990
Canis lupus familiaris
Woodward, S.L.; Fraser, S.A.; Winkler, U.; Jackson, D.S.; Kam, C.M.; Powers, J.C.; Hudig, D.
Purification and characterization of lymphocyte chymase I, a granzyme implicated in perforin-mediated lysis
J. Immunol.
160
4988-1993
1998
Rattus norvegicus
Takao, K.; Takai, S.; Ishihara, T.; Mita, S.; Miyazaki, M.
Isolation of chymase complexed with physiological inhibitor similar to secretory leukocyte protease inhibitor (SLPI) from hamster cheek pouch tissues
Biochim. Biophys. Acta
1545
146-152
2001
Cricetinae
Muilenburg, D.J.; Raymond, W.W.; Wolters, P.J.; Caughey, G.H.
Lys40 but not Arg143 influences selectivity of angiotensin conversion by human alpha-chymase
Biochim. Biophys. Acta
1596
346-356
2002
Homo sapiens
Akahoshi, F.; Ashimori, A.; Yoshimura, T.; Imada, T.; Nakajima, M.; Mitsutomi, N.; Kuwahara, S.; Ohtsuka, T.; Fukaya, C.; Miyazaki, M.; Nakamura, N.
Non-peptidic inhibitors of human chymase. Synthesis, structure-activity relationships, and pharmacokinetic profiles of a series of 5-amino-6-oxo-1,6-dihydropyrimidine-containing trifluoromethyl ketones
Bioorg. Med. Chem.
9
301-315
2001
Homo sapiens
Neumann, U.; Schechter, N.M.; Gutschow, M.
Inhibition of human chymase by 2-amino-3,1-benzoxazin-4-ones
Bioorg. Med. Chem.
9
947-954
2001
Homo sapiens
Fukami, H.; Imajo, S.; Ito, A.; Kakutani, S.; Shibata, H.; Sumida, M.; Tanaka, T.; Niwata, S.; Saitoh, M.; Kiso, Y.; Miyazaki, M.; Okunishi, H.; Urata, H.; Arakawa, K.
Substituted 3-phenylsulfonylquinazoline-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase
Drug Des. Discov.
17
69-84
2000
Homo sapiens
Ferry, G.; Gillet, L.; Bruneau, V.; Banales, J.M.; Beauverger, P.; Coge, F.; Galizzi, J.P.; Scalbert, E.; Okamoto, T.; Urata, H.; Boutin, J.A.
Development of new assays and improved procedures for the purification of recombinant human chymase
Eur. J. Biochem.
268
5885-5893
2001
Homo sapiens
Solivan, S.; Selwood, T.; Wang, Z.M.; Schechter, N.M.
Evidence for diversity of substrate specificity among members of the chymase family of serine proteases
FEBS Lett.
512
133-138
2002
Meriones unguiculatus, Cricetinae, Mus musculus, Rattus norvegicus
Tani, M.; Gyobu, Y.; Sasaki, T.; Takenouchi, O.; Kawamura, T.; Kamimura, T.; Harada, T.
SF2809 compounds, novel chymase inhibitors from Dactylosporangium sp. 1. Taxonomy, fermentation, isolation and biological properties
J. Antibiot.
57
83-88
2004
Homo sapiens
Akahoshi, F.; Ashimori, A.; Sakashita, H.; Yoshimura, T.; Imada, T.; Nakajima, M.; Mitsutomi, N.; Kuwahara, S.; Ohtsuka, T.; Fukaya, C.; Miyazaki, M.; Nakamura, N.
Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase
J. Med. Chem.
44
1286-1296
2001
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Akahoshi, F.; Ashimori, A.; Sakashita, H.; Yoshimura, T.; Eda, M.; Imada, T.; Nakajima, M.; Mitsutomi, N.; Kuwahara, S.; Ohtsuka, T.; Fukaya, C.; Miyazaki, M.; Nakamura, N.
Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase
J. Med. Chem.
44
1297-1304
2001
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Lockhart, B.E.; Vencill, J.R.; Felix, C.M.; Johnson, D.A.
Recombinant human mast-cell chymase: an improved procedure for expression in Pichia pastoris and purification of the highly active enzyme
Biotechnol. Appl. Biochem.
41
89-95
2005
Homo sapiens
Schiemann, F.; Grimm, T.A.; Hoch, J.; Gross, R.; Lindner, B.; Petersen, F.; Bulfone-Paus, S.; Brandt, E.
Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counterregulation by PF-4 through inhibition of chymase and cathepsin G
Blood
107
2234-2242
2006
Homo sapiens
Anon, A.
Immunogold ultrastructural techniques to identify subcellular sites of chymase, Charcot-Leyden crystal protein, and histamine in basophils and mast cells
Chem. Immunol. Allergy
85; 89-97
319-344
2005
Rattus norvegicus
-
Maruichi, M.; Oku, H.; Takai, S.; Muramatsu, M.; Sugiyama, T.; Imamura, Y.; Minami, M.; Ueki, M.; Satoh, B.; Sakaguchi, M.; Miyazaki, M.; Ikeda, T.
Measurement of activities in two different angiotensin II generating systems, chymase and angiotensin-converting enzyme, in the vitreous fluid of vitreoretinal diseases: a possible involvement of chymase in the pathogenesis of macular hole patients
Curr. Eye Res.
29
321-325
2004
Homo sapiens
Riekki, R.; Harvima, I.T.; Jukkola, A.; Risteli, J.; Oikarinen, A.
The production of collagen and the activity of mast-cell chymase increase in human skin after irradiation therapy
Exp. Dermatol.
13
364-371
2004
Homo sapiens
Tchougounova, E.; Lundequist, A.; Fajardo, I.; Winberg, J.O.; Abrink, M.; Pejler, G.
A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2
J. Biol. Chem.
280
9291-9296
2005
Mus musculus
Orito, K.; Suzuki, Y.; Matsuda, H.; Shirai, M.; Akahori, F.
Chymase is activated in the pulmonary inflammation and fibrosis induced by paraquat in hamsters
Tohoku J. Exp. Med.
203
287-294
2004
Mesocricetus auratus
Heikkilae, H.M.; Laetti, S.; Leskinen, M.J.; Hakala, J.K.; Kovanen, P.T.; Lindstedt, K.A.
Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha
Arterioscler. Thromb. Vasc. Biol.
28
309-314
2008
Homo sapiens
Tanaka, T.; Muto, T.; Maruoka, H.; Imajo, S.; Fukami, H.; Tomimori, Y.; Fukuda, Y.; Nakatsuka, T.
Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors
Bioorg. Med. Chem. Lett.
17
3431-3434
2007
Homo sapiens
Maruoka, H.; Muto, T.; Tanaka, T.; Imajo, S.; Tomimori, Y.; Fukuda, Y.; Nakatsuka, T.
Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors
Bioorg. Med. Chem. Lett.
17
3435-3439
2007
Homo sapiens
Bacani, C.; Frishman, W.H.
Chymase: a new pharmacologic target in cardiovascular disease
Cardiol. Rev.
14
187-193
2006
Homo sapiens
Furubayashi, K.; Takai, S.; Jin, D.; Inagaki, S.; Kimura, M.; Nishimoto, M.; Fukumoto, H.; Tanaka, K.; Katsumata, T.; Miyazaki, M.
Chymase activates promatrix metalloproteinase-9 in human abdominal aortic aneurysm
Clin. Chim. Acta
388
214-216
2008
Homo sapiens
Terakawa, M.; Tomimori, Y.; Goto, M.; Fukuda, Y.
Mast cell chymase induces expression of chemokines for neutrophils in eosinophilic EoL-1 cells and mouse peritonitis eosinophils
Eur. J. Pharmacol.
538
175-181
2006
Homo sapiens, Mus musculus
Leskinen, M.J.; Heikkilae, H.M.; Speer, M.Y.; Hakala, J.K.; Laine, M.; Kovanen, P.T.; Lindstedt, K.A.
Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-kappaB-mediated survival signaling
Exp. Cell Res.
312
1289-1298
2006
Rattus norvegicus
Gallwitz, M.; Hellman, L.
Rapid lineage-specific diversification of the mast cell chymase locus during mammalian evolution
Immunogenetics
58
641-654
2006
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Gallwitz, M.; Enoksson, M.; Hellman, L.
Expression profile of novel members of the rat mast cell protease (rMCP)-2 and (rMCP)-8 families, and functional analyses of mouse mast cell protease (mMCP)-8
Immunogenetics
59
391-405
2007
Mus musculus, Rattus norvegicus
Caughey, G.H.
Mast cell tryptases and chymases in inflammation and host defense
Immunol. Rev.
217
141-154
2007
Homo sapiens, Mus musculus
Hirata, K.; Sugama, Y.; Ikura, Y.; Ohsawa, M.; Inoue, Y.; Yamamoto, S.; Kitaichi, M.; Ueda, M.
Enhanced mast cell chymase expression in human idiopathic interstitial pneumonia
Int. J. Mol. Med.
19
565-570
2007
Homo sapiens
Zanini, A.; Chetta, A.; Saetta, M.; Baraldo, S.; DIppolito, R.; Castagnaro, A.; Neri, M.; Olivieri, D.
Chymase-positive mast cells play a role in the vascular component of airway remodeling in asthma
J. Allergy Clin. Immunol.
120
329-333
2007
Homo sapiens
Caughey, G.H.; Beauchamp, J.; Schlatter, D.; Raymond, W.W.; Trivedi, N.N.; Banner, D.; Mauser, H.; Fingerle, J.
Guinea pig chymase is leucine-specific: A novel example of functional plasticity in the chymase/granzyme family of serine peptidases
J. Biol. Chem.
283
13943-13951
2008
Cavia porcellus (A7WPL7), Cavia porcellus, Homo sapiens
Omoto, Y.; Tokime, K.; Yamanaka, K.; Habe, K.; Morioka, T.; Kurokawa, I.; Tsutsui, H.; Yamanishi, K.; Nakanishi, K.; Mizutani, H.
Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment
J. Immunol.
177
8315-8319
2006
Homo sapiens
Lee-Rueckert, M.; Vikstedt, R.; Metso, J.; Jauhiainen, M.; Kovanen, P.T.
Association of cholesteryl ester transfer protein with HDL particles reduces its proteolytic inactivation by mast cell chymase
J. Lipid Res.
49
358-368
2008
Homo sapiens
Greco, M.N.; Hawkins, M.J.; Powell, E.T.; Almond, H.R.; de Garavilla, L.; Hall, J.; Minor, L.K.; Wang, Y.; Corcoran, T.W.; Di Cera, E.; Cantwell, A.M.; Savvides, S.N.; Damiano, B.P.; Maryanoff, B.E.
Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase
J. Med. Chem.
50
1727-1730
2007
Homo sapiens
Miyazaki, M.; Takai, S.
Tissue angiotensin II generating system by angiotensin-converting enzyme and chymase
J. Pharmacol. Sci.
100
391-397
2006
Homo sapiens
Jin, D.; Ueda, H.; Takai, S.; Muramatsu, M.; Furubayashi, K.; Ibaraki, T.; Kishi, K.; Katsuoka, Y.; Miyazaki, M.
Roles of chymase in stenosis occurring after polytetrafluoroethylene graft implantations
Life Sci.
81
1291-1300
2007
Canis lupus familiaris
Sharma, R.; Prasad, V.; McCarthy, E.T.; Savin, V.J.; Dileepan, K.N.; Stechschulte, D.J.; Lianos, E.; Wiegmann, T.; Sharma, M.
Chymase increases glomerular albumin permeability via protease-activated receptor-2
Mol. Cell. Biochem.
297
161-169
2007
Rattus norvegicus
Zhao, X.Y.; Zhao, L.Y.; Zheng, Q.S.; Su, J.L.; Guan, H.; Shang, F.J.; Niu, X.L.; He, Y.P.; Lu, X.L.
Chymase induces profibrotic response via transforming growth factor-beta1/Smad activation in rat cardiac fibroblasts
Mol. Cell. Biochem.
310
159-166
2008
Rattus norvegicus
Reimer, J.M.; Enoksson, M.; Samollow, P.B.; Hellman, L.
Extended substrate specificity of opossum chymase - Implications for the origin of mast cell chymases
Mol. Immunol.
45
2116-2125
2008
Monodelphis domestica
Andersson, M.K.; Pemberton, A.D.; Miller, H.R.; Hellman, L.
Extended cleavage specificity of mMCP-1, the major mucosal mast cell protease in mouse - High specificity indicates high substrate selectivity
Mol. Immunol.
45
2548-2558
2008
Mus musculus
Andersson, M.K.; Karlson, U.; Hellman, L.
The extended cleavage specificity of the rodent beta-chymases rMCP-1 and mMCP-4 reveal major functional similarities to the human mast cell chymase
Mol. Immunol.
45
766-775
2008
Mus musculus, Rattus norvegicus
Miyazaki, M.; Takai, S.; Jin, D.; Muramatsu, M.
Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models
Pharmacol. Ther.
112
668-676
2006
Canis lupus familiaris, Homo sapiens, Mesocricetus auratus
Wang, Y.; Gu, Y.; Zhang, Y.; Lewis, D.F.; Alexander, J.S.; Granger, D.N.
Increased chymotrypsin-like protease (chymase) expression and activity in placentas from women with preeclampsia
Placenta
28
263-269
2007
Homo sapiens
Vaali, K.; Puumalainen, T.J.; Lehto, M.; Wolff, H.; Rita, H.; Alenius, H.; Palosuo, T.
Murine model of food allergy after epicutaneous sensitization: role of mucosal mast cell protease-1
Scand. J. Gastroenterol.
41
1405-1413
2006
Mus musculus
Chen, W.; Yu, M.H.; Li, Y.M.; Chen, W.J.; Xia, Y.P.
Beneficial effects of astragalus polysaccharides treatment on cardiac chymase activities and cardiomyopathy in diabetic hamsters
Acta Diabetol.
47 Suppl. 1
35-46
2010
Mesocricetus auratus
Inoue, N.; Muramatsu, M.; Jin, D.; Takai, S.; Hayashi, T.; Katayama, H.; Kitaura, Y.; Tamai, H.; Miyazaki, M.
Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice
Atherosclerosis
204
359-364
2008
Mus musculus
Belkowski, S.M.; Masucci, J.; Mahan, A.; Kervinen, J.; Olson, M.; de Garavilla, L.; DAndrea, M.R.
Cleaved SLPI, a novel biomarker of chymase activity
Biol. Chem.
389
1219-1224
2008
Homo sapiens
Prosser, H.C.; Forster, M.E.; Richards, A.M.; Pemberton, C.J.
Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: effects of PA12 upon cardiac haemodynamics
Cardiovasc. Res.
82
40-50
2009
Rattus norvegicus
Terakawa, M.; Fujieda, Y.; Tomimori, Y.; Muto, T.; Tanaka, T.; Maruoka, H.; Nagahira, K.; Ogata, A.; Nakatsuka, T.; Fukuda, Y.
Oral chymase inhibitor SUN13834 ameliorates skin inflammation as well as pruritus in mouse model for atopic dermatitis
Eur. J. Pharmacol.
601
186-191
2008
Mus musculus
Cristovam, P.C.; Arnoni, C.P.; de Andrade, M.C.; Casarini, D.E.; Pereira, L.G.; Schor, N.; Boim, M.A.
ACE-dependent and chymase-dependent angiotensin II generation in normal and glucose-stimulated human mesangial cells
Exp. Biol. Med.
233
1035-1043
2008
Homo sapiens
Magnusson, S.E.; Pejler, G.; Kleinau, S.; Abrink, M.
Mast cell chymase contributes to the antibody response and the severity of autoimmune arthritis
FASEB J.
23
875-882
2009
Mus musculus
Wong, C.K.; Ng, S.S.; Lun, S.W.; Cao, J.; Lam, C.W.
Signalling mechanisms regulating the activation of human eosinophils by mast-cell-derived chymase: implications for mast cell-eosinophil interaction in allergic inflammation
Immunology
126
579-587
2009
Homo sapiens
Andersson, M.K.; Enoksson, M.; Gallwitz, M.; Hellman, L.
The extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile
Int. Immunol.
21
95-104
2009
Homo sapiens
Firth, J.D.; Uitto, V.J.; Putnins, E.E.
Mechanical induction of an epithelial cell chymase associated with wound edge migration
J. Biol. Chem.
283
34983-34993
2008
Homo sapiens
Sugimoto, M.; Furuta, T.; Kodaira, C.; Nishino, M.; Yamade, M.; Ikuma, M.; Sugimura, H.; Hishida, A.
Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan
J. Gastroenterol.
43
751-761
2008
Homo sapiens
Hossny, E.M.; Amr, N.H.; Elsayed, S.B.; Nasr, R.A.; Ibraheim, E.M.
Association of polymorphisms in the mast cell chymase gene promoter region (-1903 g/A) and (TG)n(GA)m repeat downstream of the gene with bronchial asthma in children
J. Investig. Allergol. Clin. Immunol.
18
376-381
2008
Homo sapiens
Guillabert, A.; Wittamer, V.; Bondue, B.; Godot, V.; Imbault, V.; Parmentier, M.; Communi, D.
Role of neutrophil proteinase 3 and mast cell chymase in chemerin proteolytic regulation
J. Leukoc. Biol.
84
1530-1538
2008
Homo sapiens
Simard, E.; Jin, D.; Takai, S.; Miyazaki, M.; Brochu, I.; DOrleans-Juste, P.
Chymase-dependent conversion of Big endothelin-1 in the mouse in vivo
J. Pharmacol. Exp. Ther.
328
540-548
2009
Mus musculus
Amano, N.; Takai, S.; Jin, D.; Ueda, K.; Miyazaki, M.
Possible roles of mast cell-derived chymase for skin rejuvenation
Lasers Med. Sci.
24
223-229
2009
Mesocricetus auratus
McEuen, A.R.; Walls, A.F.
Purification and characterization of mast cell tryptase and chymase from human tissues
Methods Mol. Med.
138
299-317
2008
Homo sapiens
Togawa, H.; Nakanishi, K.; Shima, Y.; Obana, M.; Sako, M.; Nozu, K.; Tanaka, R.; Iijima, K.; Yoshikawa, N.
Increased chymase-positive mast cells in children with crescentic glomerulonephritis
Pediatr. Nephrol.
24
1071-1075
2009
Homo sapiens
DOrleans-Juste, P.; Houde, M.; Rae, G.A.; Bkaily, G.; Carrier, E.; Simard, E.
Endothelin-1 (1-31): from chymase-dependent synthesis to cardiovascular pathologies
Vascul. Pharmacol.
49
51-62
2008
Homo sapiens, Mus musculus
Belkowski, S.M.; Boot, J.D.; Mascelli, M.A.; Diamant, Z.; de Garavilla, L.; Hertzog, B.; Polkovitch, D.; Towers, M.; Batheja, A.; DAndrea, M.R.
Cleaved secretory leucocyte protease inhibitor as a biomarker of chymase activity in allergic airway disease
Clin. Exp. Allergy
39
1179-1186
2009
Homo sapiens
Tashiro, K.; Takai, S.; Jin, D.; Yamamoto, H.; Komeda, K.; Hayashi, M.; Tanaka, K.; Tanigawa, N.; Miyazaki, M.
Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet
Hepatol. Res.
40
514-523
2010
Mesocricetus auratus
Wei, C.C.; Hase, N.; Inoue, Y.; Bradley, E.W.; Yahiro, E.; Li, M.; Naqvi, N.; Powell, P.C.; Shi, K.; Takahashi, Y.; Saku, K.; Urata, H.; Dellitalia, L.J.; Husain, A.
Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents
J. Clin. Invest.
120
1229-1239
2010
Mus musculus
Chen, W.; Li, Y.M.; Yu, M.H.
Astragalus polysaccharides inhibited diabetic cardiomyopathy in hamsters depending on suppression of heart chymase activation
J. Diabetes Complicat.
24
199-208
2010
Mesocricetus auratus
Takai, S.; Jin, D.; Ohzu, M.; Tanaka, K.; Miyazaki, M.
Chymase inhibition provides pancreatic islet protection in hamsters with streptozotocin-induced diabetes
J. Pharmacol. Sci.
110
459-465
2009
Mesocricetus auratus
Kawarai, S.; Masuda, K.; Ohmori, K.; Matsuura, S.; Yasuda, N.; Nagata, M.; Sakaguchi, M.; Tsujimoto, H.
Cultivation and characterization of canine skin-derived mast cells
J. Vet. Med. Sci.
72
131-140
2010
Canis lupus familiaris
Bot, I.; Bot, M.; van Heiningen, S.H.; van Santbrink, P.J.; Lankhuizen, I.M.; Hartman, P.; Gruener, S.; Hilpert, H.; van Berkel, T.J.; Fingerle, J.; Biessen, E.A.
Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE-/- mice
Cardiovasc. Res.
89
244-252
2011
Homo sapiens
Andersson, M.K.; Thorpe, M.; Hellman, L.
Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2 of substrates
FEBS J.
277
2255-2267
2010
Homo sapiens
Korkmaz, B.; Jegot, G.; Lau, L.C.; Thorpe, M.; Pitois, E.; Juliano, L.; Walls, A.F.; Hellman, L.; Gauthier, F.
Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates
FEBS J.
278
2635-2646
2011
Homo sapiens
Gallwitz, M.; Enoksson, M.; Thorpe, M.; Ge, X.; Hellman, L.
The extended substrate recognition profile of the dog mast cell chymase reveals similarities and differences to the human chymase
Int. Immunol.
22
421-431
2010
Canis lupus familiaris
Akahoshi, M.; Song, C.H.; Piliponsky, A.M.; Metz, M.; Guzzetta, A.; Abrink, M.; Schlenner, S.M.; Feyerabend, T.B.; Rodewald, H.R.; Pejler, G.; Tsai, M.; Galli, S.J.
Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice
J. Clin. Invest.
121
4180-4191
2011
Mus musculus
Piliponsky, A.M.; Chen, C.C.; Rios, E.J.; Treuting, P.M.; Lahiri, A.; Abrink, M.; Pejler, G.; Tsai, M.; Galli, S.J.
The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis
Am. J. Pathol.
181
875-886
2012
Mus musculus (P21812), Mus musculus
Nabe, T.; Kijitani, Y.; Kitagawa, Y.; Sakano, E.; Ueno, T.; Fujii, M.; Nakao, S.; Sakai, M.; Takai, S.
Involvement of chymase in allergic conjunctivitis of guinea pigs
Exp. Eye Res.
113
74-79
2013
Cavia porcellus (A7WPL7), Cavia porcellus
Kosanovic, D.; Dahal, B.K.; Wygrecka, M.; Reiss, I.; Guenther, A.; Ghofrani, H.A.; Weissmann, N.; Grimminger, F.; Seeger, W.; Schermuly, R.T.; Banat, G.A.
Mast cell chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis?
Histol. Histopathol.
28
691-699
2013
Rattus norvegicus
Dong, X.; Zhang, C.; Ma, S.; Wen, H.
Mast cell chymase in keloid induces profibrotic response via transforming growth factor-beta1/Smad activation in keloid fibroblasts
Int. J. Clin. Exp. Pathol.
7
3596-3607
2014
Homo sapiens
Roy, A.; Ganesh, G.; Sippola, H.; Bolin, S.; Sawesi, O.; Dagaelv, A.; Schlenner, S.M.; Feyerabend, T.; Rodewald, H.R.; Kjellen, L.; Hellman, L.; Abrink, M.
Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation
J. Biol. Chem.
289
237-250
2014
Homo sapiens (P23946), Homo sapiens, Mus musculus (P21812), Mus musculus
Reber, L.L.; Daubeuf, F.; Pejler, G.; Abrink, M.; Frossard, N.
Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism
J. Immunol.
192
1847-1854
2014
Mus musculus (P21812), Mus musculus
Houde, M.; Jamain, M.D.; Labonte, J.; Desbiens, L.; Pejler, G.; Gurish, M.; Takai, S.; DOrleans-Juste, P.
Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1
J. Pharmacol. Exp. Ther.
346
31-37
2013
Mus musculus (P21812), Mus musculus
Takai, S.; Jin, D.; Miyazaki, M.
Multiple mechanisms for the action of chymase inhibitors
J. Pharmacol. Sci.
118
311-316
2012
Homo sapiens (P23946)
Beghdadi, W.; Madjene, L.C.; Claver, J.; Pejler, G.; Beaudoin, L.; Lehuen, A.; Daugas, E.; Blank, U.
Mast cell chymase protects against renal fibrosis in murine unilateral ureteral obstruction
Kidney Int.
84
317-326
2013
Mus musculus (P21812), Mus musculus
Dong, X.; Chen, J.; Zhang, Y.; Cen, Y.
Mast cell chymase promotes cell proliferation and expression of certain cytokines in a dose-dependent manner
Mol. Med. Rep.
5
1487-1490
2012
Homo sapiens (P23946), Homo sapiens
Waern, I.; Lundequist, A.; Pejler, G.; Wernersson, S.
Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation
Mucosal Immunol.
6
911-920
2013
Mus musculus (P21812), Mus musculus
de Souza, D.A.; Toso, V.D.; Campos, M.R.; Lara, V.S.; Oliver, C.; Jamur, M.C.
Expression of mast cell proteases correlates with mast cell maturation and angiogenesis during tumor progression
PLoS ONE
7
e40790
2012
Mus musculus, Mus musculus (P21812)
Ahooghalandari, P.; Hanke, N.; Thorpe, M.; Witte, A.; Messinger, J.; Hellman, L.
Mutations in Arg143 and Lys192 of the human mast cell chymase markedly affect the activity of five potent human chymase inhibitors
PLoS ONE
8
e65988
2013
Homo sapiens (P23946), Homo sapiens
Smith, E.T.; Perry, E.T.; Sears, M.B.; Johnson, D.A.
Expression of recombinant human mast cell chymase with Asn-linked glycans in glycoengineered Pichia pastoris
Protein Expr. Purif.
102
69-75
2014
Homo sapiens
Wang, Y.; Shi, G.P.
Mast cell chymase and tryptase in abdominal aortic aneurysm formation
Trends Cardiovasc. Med.
22
150-155
2012
Homo sapiens (P23946), Homo sapiens
Dubey, A.; Marabotti, A.; Ramteke, P.W.; Facchiano, A.
Interaction of human chymase with ginkgolides, terpene trilactones of Ginkgo biloba investigated by molecular docking simulations
Biochem. Biophys. Res. Commun.
473
449-454
2016
Homo sapiens (P23946), Homo sapiens
Chu, Y.; Wang, J.; Zhou, X.
Mast cell chymase in synovial fluid of collagen-induced-arthritis rats regulates gelatinase release and promotes synovial fibroblasts proliferation via FAK/p21 signaling pathway
Biochem. Biophys. Res. Commun.
514
336-343
2019
Rattus norvegicus
de Souza Junior, D.A.; Santana, A.C.; da Silva, E.Z.; Oliver, C.; Jamur, M.C.
The role of mast cell specific chymases and tryptases in tumor angiogenesis
BioMed Res. Int.
2015
142359
2015
Homo sapiens, Mus musculus
Futamura-Takahashi, J.; Tanaka, T.; Sugawara, H.; Iwashita, S.; Imajo, S.; Oyama, Y.; Muto, T.
Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors
Bioorg. Med. Chem. Lett.
28
188-192
2018
Homo sapiens (P23946), Homo sapiens
Lipitsae, T.; Siiskonen, H.; Naukkarinen, A.; Harvima, I.T.
Mast cell chymase degrades fibrinogen and fibrin
Br. J. Dermatol.
181
296-303
2019
Homo sapiens
Fu, Z.; Akula, S.; Thorpe, M.; Chahal, G.; de Garavilla, L.; Kervinen, J.; Hellman, L.
Extended cleavage specificity of sheep mast cell protease-2 A classical chymase with preference to aromatic P1 substrate residues
Dev. Comp. Immunol.
92
160-169
2019
Ovis aries (P79204), Ovis aries
Gendrin, C.; Shubin, N.J.; Boldenow, E.; Merillat, S.; Clauson, M.; Power, D.; Doran, K.S.; Abrink, M.; Pejler, G.; Rajagopal, L.; Piliponsky, A.M.
Mast cell chymase decreases the severity of group B Streptococcus infections
J. Allergy Clin. Immunol.
142
120-129.e6
2018
Mus musculus
Sansoe, G.; Aragno, M.; Mastrocola, R.; Mengozzi, G.; Novo, E.; Parola, M.
Role of chymase in the development of liver cirrhosis and its complications experimental and human data
PLoS ONE
11
e0162644
2016
Homo sapiens, Rattus norvegicus
Thorpe, M.; Fu, Z.; Albat, E.; Akula, S.; de Garavilla, L.; Kervinen, J.; Hellman, L.
Extended cleavage specificities of mast cell proteases 1 and 2 from golden hamster Classical chymase and an elastolytic protease comparable to rat and mouse MCP-5
PLoS ONE
13
e0207826
2018
Mesocricetus auratus
Chang, H.; Sun, Y.; Yeh, F.; Tseng, I.; Chang, C.; Lin, C.
Detection of chymase activity using a specific peptide probe conjugated onto gold nanoparticles
RSC Adv.
8
29013-29021
2018
Homo sapiens
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