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Reference on EC 3.4.21.39 - chymase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kido, H.; Fukusen, N.; Katunuma, N.
Chymotrypsin- and trypsin-type serine proteases in rat mast cells: properties and functions
Arch. Biochem. Biophys.
239
436-443
1985
Rattus norvegicus
Manually annotated by BRENDA team
Powers, J.C.; Tanaka, T.; Harper, J.W.; Minematsu, Y.; Barker, L.; Lincoln, D.; Crumley, K.V.; Fraki, J.E.; Schechter, N.M.; Lazarus, G.G.; Nakajima, K.; Nakashino, K.; Neurath, H.; Woodbury, R.G.
Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors
Biochemistry
24
2048-2058
1985
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Yoshida, N.; Everitt, M.T.; Neurath, H.; Woodbury, R.G.; Powers, J.C.
Substrate specificity of two chymotrypsin-like proteases from rat mast cells. Studies with peptide 4-nitroanilides and comparison with cathepsin G
Biochemistry
19
5799-5804
1980
Rattus norvegicus
Manually annotated by BRENDA team
Trong, H.L.; Parmelee, D.C.; Walsh, K.A.; Neurath, H.; Woodbury, R.G.
Amino acid sequence of rat mast cell protease I (chymase)
Biochemistry
26
6988-6994
1987
Rattus norvegicus
Manually annotated by BRENDA team
Sayama, S.; Iozzo, R.V.; Lazarus, G.S.; Schechter, N.M.
Human skin chymotrypsin-like proteinase chymase. Subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans
J. Biol. Chem.
262
6808-6815
1987
Homo sapiens
Manually annotated by BRENDA team
Kokkonen, J.O.; Vartiainen, M.; Kovanen, P.T.
Low density lipoprotein degradation by secretory granules of rat mast cells. Sequential degradation of apolipoprotein B by granule chymase and carboxypeptidase A
J. Biol. Chem.
261
16067-16072
1986
Rattus norvegicus
Manually annotated by BRENDA team
Kido, H.; Fukusen, N.; Katunuma, N.
Inhibition of chymase activity by long chain fatty acids
Arch. Biochem. Biophys.
230
610-614
1984
Rattus norvegicus
Manually annotated by BRENDA team
Fink, E.; Nettelbeck, R.; Fritz, H.
Inhibition of mast cell chymase by eglin c and antileukoprotease (HUSI-I). Indications for potential biological functions of these inhibitors
Biol. Chem. Hoppe-Seyler
367
567-571
1986
Sus scrofa
Manually annotated by BRENDA team
Katunuma, N.; Fukusen, N.; Kido, H.
Biological functions of serine proteases in the granules of rat mast cells
Adv. Enzyme Regul.
25
241-255
1986
Rattus norvegicus
Manually annotated by BRENDA team
Johnson, L.A.; Moon, K.E.; Eisenberg, M.
Purification to homogeneity of the human skin chymotryptic proteinase chymase
Anal. Biochem.
155
358-364
1986
Homo sapiens
Manually annotated by BRENDA team
Fukusen, N.; Kido, H.; Katunuma, N.
Inhibition of chymase activity by phosphoglycerides
Arch. Biochem. Biophys.
237
118-123
1985
Rattus norvegicus
Manually annotated by BRENDA team
Yurt, R.; Austen, K.F.
Preparative purification of the rat mast cell chymase: characterization and interaction with granule components
J. Exp. Med.
146
1405-1419
1977
Rattus norvegicus
Manually annotated by BRENDA team
Pereira, P.J.B.; Wang, Z.M.; Rubin, H.; Huber, R.; Bode, W.; Schechter, N.M.; Strobl, S.
The 2.2 A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity
J. Mol. Biol.
286
163-173
1999
Homo sapiens
Manually annotated by BRENDA team
McGrath, M.E.; Mirzadegan, T.; Schmidt, B.F.
Crystal structure of phenylmethanesulfonyl fluoride-treated human chymase at 1.9 A
Biochemistry
36
14318-14324
1997
Homo sapiens (P23946), Homo sapiens
Manually annotated by BRENDA team
Takao, K.; Takai, S.; Shiota, N.; Song, K.; Nishimura, K.; Ishihara, T.; Miyazaki, M.
Lack of effect of carbohydrate depletion on some properties of human mast cell chymase
Biochim. Biophys. Acta
1427
74-81
1999
Homo sapiens
Manually annotated by BRENDA team
Takai, S.; Shiota, N.; Sakaguchi, M.; Muraguchi, H.; Matsumura, E.; Miyazaki, M.
Characterization of chymase from human vascular tissues
Clin. Chim. Acta
265
13-20
1997
Homo sapiens
Manually annotated by BRENDA team
Pejler, G.; Berg, L.
Regulation of rat mast cell protease 1 activity. Protease inhibition is prevented by heparin proteoglycan
Eur. J. Biochem.
233
192-199
1995
Rattus norvegicus
Manually annotated by BRENDA team
Sukenaga, Y.; Kido, H.; Neki, A.; Enomoto, M.; Ishida, K.; Takagi, K.; Katunuma, N.
Purification and molecular cloning of chymase from human tonsils
FEBS Lett.
323
119-122
1993
Homo sapiens
Manually annotated by BRENDA team
Newlands, G.F.Y.; Knox, D.P.; Pirie-Sheperd, S.R.; Miller, H.R.P.
Biochemical and immunological characterization of multiple glycoforms of mouse mast cell protease 1: comparison with an isolated murine serosal mast cell protease (MMCP-4)
Biochem. J.
294
127-135
1993
Mus musculus
Manually annotated by BRENDA team
Schechter, N.M.; Jordan, L.M.; James, A.M.; Cooperman, B.S.; Wang, Z.; Rubin, H.
Reaction of human chymase with reactive site variants of alpha 1-antichymotrypsin. Modulation of inhibitor versus substrate properties
J. Biol. Chem.
268
23626-23633
1993
Homo sapiens
Manually annotated by BRENDA team
McGrath, M.E.; Osawa, A.E.; Barnes, M.G.; Clark, J.M.; Mortara, K.D.; Schmidt, B.F.
Production of crystallizable human chymase from a Bacillus subtilis system
FEBS Lett.
413
486-488
1997
Homo sapiens
Manually annotated by BRENDA team
Waldeck, K.; Lindberg, B.F.; Persson, K.; Andersson, K.E.
Characterization of angiotensin II formation in human isolated bladder by selective inhibitors of ACE and human chymase: a functional and biochemical study
Br. J. Pharmacol.
121
1081-1086
1997
Homo sapiens
Manually annotated by BRENDA team
Schechter, N.M.; Sprows, J.L.; Schoenberger, O.L.; Lazarus, G.S.; Cooperman, B.S.; Rubin, H.
Reaction of human skin chymotrypsin-like proteinase chymase with plasma proteinase inhibitors
J. Biol. Chem.
264
21308-21315
1989
Homo sapiens
Manually annotated by BRENDA team
Takai, S.; Shiota, N.; Yamamoto, D.; Okunishi, H.; Miyazaki, M.
Purification and characterization of angiotensin II-generating chymase from hamster cheek pouch
Life Sci.
58
591-597
1996
Mesocricetus auratus
Manually annotated by BRENDA team
Caughey, G.H.; Raymond, W.W.; Vanderslice, P.
Dog mast cell chymase: molecular cloning and characterization
Biochemistry
29
5166-5171
1990
Canis lupus familiaris
Manually annotated by BRENDA team
Woodward, S.L.; Fraser, S.A.; Winkler, U.; Jackson, D.S.; Kam, C.M.; Powers, J.C.; Hudig, D.
Purification and characterization of lymphocyte chymase I, a granzyme implicated in perforin-mediated lysis
J. Immunol.
160
4988-1993
1998
Rattus norvegicus
Manually annotated by BRENDA team
Takao, K.; Takai, S.; Ishihara, T.; Mita, S.; Miyazaki, M.
Isolation of chymase complexed with physiological inhibitor similar to secretory leukocyte protease inhibitor (SLPI) from hamster cheek pouch tissues
Biochim. Biophys. Acta
1545
146-152
2001
Cricetinae
Manually annotated by BRENDA team
Muilenburg, D.J.; Raymond, W.W.; Wolters, P.J.; Caughey, G.H.
Lys40 but not Arg143 influences selectivity of angiotensin conversion by human alpha-chymase
Biochim. Biophys. Acta
1596
346-356
2002
Homo sapiens
Manually annotated by BRENDA team
Akahoshi, F.; Ashimori, A.; Yoshimura, T.; Imada, T.; Nakajima, M.; Mitsutomi, N.; Kuwahara, S.; Ohtsuka, T.; Fukaya, C.; Miyazaki, M.; Nakamura, N.
Non-peptidic inhibitors of human chymase. Synthesis, structure-activity relationships, and pharmacokinetic profiles of a series of 5-amino-6-oxo-1,6-dihydropyrimidine-containing trifluoromethyl ketones
Bioorg. Med. Chem.
9
301-315
2001
Homo sapiens
Manually annotated by BRENDA team
Neumann, U.; Schechter, N.M.; Gutschow, M.
Inhibition of human chymase by 2-amino-3,1-benzoxazin-4-ones
Bioorg. Med. Chem.
9
947-954
2001
Homo sapiens
Manually annotated by BRENDA team
Fukami, H.; Imajo, S.; Ito, A.; Kakutani, S.; Shibata, H.; Sumida, M.; Tanaka, T.; Niwata, S.; Saitoh, M.; Kiso, Y.; Miyazaki, M.; Okunishi, H.; Urata, H.; Arakawa, K.
Substituted 3-phenylsulfonylquinazoline-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase
Drug Des. Discov.
17
69-84
2000
Homo sapiens
Manually annotated by BRENDA team
Ferry, G.; Gillet, L.; Bruneau, V.; Banales, J.M.; Beauverger, P.; Coge, F.; Galizzi, J.P.; Scalbert, E.; Okamoto, T.; Urata, H.; Boutin, J.A.
Development of new assays and improved procedures for the purification of recombinant human chymase
Eur. J. Biochem.
268
5885-5893
2001
Homo sapiens
Manually annotated by BRENDA team
Solivan, S.; Selwood, T.; Wang, Z.M.; Schechter, N.M.
Evidence for diversity of substrate specificity among members of the chymase family of serine proteases
FEBS Lett.
512
133-138
2002
Meriones unguiculatus, Cricetinae, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Tani, M.; Gyobu, Y.; Sasaki, T.; Takenouchi, O.; Kawamura, T.; Kamimura, T.; Harada, T.
SF2809 compounds, novel chymase inhibitors from Dactylosporangium sp. 1. Taxonomy, fermentation, isolation and biological properties
J. Antibiot.
57
83-88
2004
Homo sapiens
Manually annotated by BRENDA team
Akahoshi, F.; Ashimori, A.; Sakashita, H.; Yoshimura, T.; Imada, T.; Nakajima, M.; Mitsutomi, N.; Kuwahara, S.; Ohtsuka, T.; Fukaya, C.; Miyazaki, M.; Nakamura, N.
Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase
J. Med. Chem.
44
1286-1296
2001
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Akahoshi, F.; Ashimori, A.; Sakashita, H.; Yoshimura, T.; Eda, M.; Imada, T.; Nakajima, M.; Mitsutomi, N.; Kuwahara, S.; Ohtsuka, T.; Fukaya, C.; Miyazaki, M.; Nakamura, N.
Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase
J. Med. Chem.
44
1297-1304
2001
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Lockhart, B.E.; Vencill, J.R.; Felix, C.M.; Johnson, D.A.
Recombinant human mast-cell chymase: an improved procedure for expression in Pichia pastoris and purification of the highly active enzyme
Biotechnol. Appl. Biochem.
41
89-95
2005
Homo sapiens
Manually annotated by BRENDA team
Schiemann, F.; Grimm, T.A.; Hoch, J.; Gross, R.; Lindner, B.; Petersen, F.; Bulfone-Paus, S.; Brandt, E.
Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counterregulation by PF-4 through inhibition of chymase and cathepsin G
Blood
107
2234-2242
2006
Homo sapiens
Manually annotated by BRENDA team
Anon, A.
Immunogold ultrastructural techniques to identify subcellular sites of chymase, Charcot-Leyden crystal protein, and histamine in basophils and mast cells
Chem. Immunol. Allergy
85; 89-97
319-344
2005
Rattus norvegicus
-
Manually annotated by BRENDA team
Maruichi, M.; Oku, H.; Takai, S.; Muramatsu, M.; Sugiyama, T.; Imamura, Y.; Minami, M.; Ueki, M.; Satoh, B.; Sakaguchi, M.; Miyazaki, M.; Ikeda, T.
Measurement of activities in two different angiotensin II generating systems, chymase and angiotensin-converting enzyme, in the vitreous fluid of vitreoretinal diseases: a possible involvement of chymase in the pathogenesis of macular hole patients
Curr. Eye Res.
29
321-325
2004
Homo sapiens
Manually annotated by BRENDA team
Riekki, R.; Harvima, I.T.; Jukkola, A.; Risteli, J.; Oikarinen, A.
The production of collagen and the activity of mast-cell chymase increase in human skin after irradiation therapy
Exp. Dermatol.
13
364-371
2004
Homo sapiens
Manually annotated by BRENDA team
Tchougounova, E.; Lundequist, A.; Fajardo, I.; Winberg, J.O.; Abrink, M.; Pejler, G.
A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2
J. Biol. Chem.
280
9291-9296
2005
Mus musculus
Manually annotated by BRENDA team
Orito, K.; Suzuki, Y.; Matsuda, H.; Shirai, M.; Akahori, F.
Chymase is activated in the pulmonary inflammation and fibrosis induced by paraquat in hamsters
Tohoku J. Exp. Med.
203
287-294
2004
Mesocricetus auratus
Manually annotated by BRENDA team
Heikkilae, H.M.; Laetti, S.; Leskinen, M.J.; Hakala, J.K.; Kovanen, P.T.; Lindstedt, K.A.
Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha
Arterioscler. Thromb. Vasc. Biol.
28
309-314
2008
Homo sapiens
Manually annotated by BRENDA team
Tanaka, T.; Muto, T.; Maruoka, H.; Imajo, S.; Fukami, H.; Tomimori, Y.; Fukuda, Y.; Nakatsuka, T.
Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors
Bioorg. Med. Chem. Lett.
17
3431-3434
2007
Homo sapiens
Manually annotated by BRENDA team
Maruoka, H.; Muto, T.; Tanaka, T.; Imajo, S.; Tomimori, Y.; Fukuda, Y.; Nakatsuka, T.
Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors
Bioorg. Med. Chem. Lett.
17
3435-3439
2007
Homo sapiens
Manually annotated by BRENDA team
Bacani, C.; Frishman, W.H.
Chymase: a new pharmacologic target in cardiovascular disease
Cardiol. Rev.
14
187-193
2006
Homo sapiens
Manually annotated by BRENDA team
Furubayashi, K.; Takai, S.; Jin, D.; Inagaki, S.; Kimura, M.; Nishimoto, M.; Fukumoto, H.; Tanaka, K.; Katsumata, T.; Miyazaki, M.
Chymase activates promatrix metalloproteinase-9 in human abdominal aortic aneurysm
Clin. Chim. Acta
388
214-216
2008
Homo sapiens
Manually annotated by BRENDA team
Terakawa, M.; Tomimori, Y.; Goto, M.; Fukuda, Y.
Mast cell chymase induces expression of chemokines for neutrophils in eosinophilic EoL-1 cells and mouse peritonitis eosinophils
Eur. J. Pharmacol.
538
175-181
2006
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Leskinen, M.J.; Heikkilae, H.M.; Speer, M.Y.; Hakala, J.K.; Laine, M.; Kovanen, P.T.; Lindstedt, K.A.
Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-kappaB-mediated survival signaling
Exp. Cell Res.
312
1289-1298
2006
Rattus norvegicus
Manually annotated by BRENDA team
Gallwitz, M.; Hellman, L.
Rapid lineage-specific diversification of the mast cell chymase locus during mammalian evolution
Immunogenetics
58
641-654
2006
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Gallwitz, M.; Enoksson, M.; Hellman, L.
Expression profile of novel members of the rat mast cell protease (rMCP)-2 and (rMCP)-8 families, and functional analyses of mouse mast cell protease (mMCP)-8
Immunogenetics
59
391-405
2007
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Caughey, G.H.
Mast cell tryptases and chymases in inflammation and host defense
Immunol. Rev.
217
141-154
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Hirata, K.; Sugama, Y.; Ikura, Y.; Ohsawa, M.; Inoue, Y.; Yamamoto, S.; Kitaichi, M.; Ueda, M.
Enhanced mast cell chymase expression in human idiopathic interstitial pneumonia
Int. J. Mol. Med.
19
565-570
2007
Homo sapiens
Manually annotated by BRENDA team
Zanini, A.; Chetta, A.; Saetta, M.; Baraldo, S.; DIppolito, R.; Castagnaro, A.; Neri, M.; Olivieri, D.
Chymase-positive mast cells play a role in the vascular component of airway remodeling in asthma
J. Allergy Clin. Immunol.
120
329-333
2007
Homo sapiens
Manually annotated by BRENDA team
Caughey, G.H.; Beauchamp, J.; Schlatter, D.; Raymond, W.W.; Trivedi, N.N.; Banner, D.; Mauser, H.; Fingerle, J.
Guinea pig chymase is leucine-specific: A novel example of functional plasticity in the chymase/granzyme family of serine peptidases
J. Biol. Chem.
283
13943-13951
2008
Cavia porcellus (A7WPL7), Cavia porcellus, Homo sapiens
Manually annotated by BRENDA team
Omoto, Y.; Tokime, K.; Yamanaka, K.; Habe, K.; Morioka, T.; Kurokawa, I.; Tsutsui, H.; Yamanishi, K.; Nakanishi, K.; Mizutani, H.
Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment
J. Immunol.
177
8315-8319
2006
Homo sapiens
Manually annotated by BRENDA team
Lee-Rueckert, M.; Vikstedt, R.; Metso, J.; Jauhiainen, M.; Kovanen, P.T.
Association of cholesteryl ester transfer protein with HDL particles reduces its proteolytic inactivation by mast cell chymase
J. Lipid Res.
49
358-368
2008
Homo sapiens
Manually annotated by BRENDA team
Greco, M.N.; Hawkins, M.J.; Powell, E.T.; Almond, H.R.; de Garavilla, L.; Hall, J.; Minor, L.K.; Wang, Y.; Corcoran, T.W.; Di Cera, E.; Cantwell, A.M.; Savvides, S.N.; Damiano, B.P.; Maryanoff, B.E.
Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase
J. Med. Chem.
50
1727-1730
2007
Homo sapiens
Manually annotated by BRENDA team
Miyazaki, M.; Takai, S.
Tissue angiotensin II generating system by angiotensin-converting enzyme and chymase
J. Pharmacol. Sci.
100
391-397
2006
Homo sapiens
Manually annotated by BRENDA team
Jin, D.; Ueda, H.; Takai, S.; Muramatsu, M.; Furubayashi, K.; Ibaraki, T.; Kishi, K.; Katsuoka, Y.; Miyazaki, M.
Roles of chymase in stenosis occurring after polytetrafluoroethylene graft implantations
Life Sci.
81
1291-1300
2007
Canis lupus familiaris
Manually annotated by BRENDA team
Sharma, R.; Prasad, V.; McCarthy, E.T.; Savin, V.J.; Dileepan, K.N.; Stechschulte, D.J.; Lianos, E.; Wiegmann, T.; Sharma, M.
Chymase increases glomerular albumin permeability via protease-activated receptor-2
Mol. Cell. Biochem.
297
161-169
2007
Rattus norvegicus
Manually annotated by BRENDA team
Zhao, X.Y.; Zhao, L.Y.; Zheng, Q.S.; Su, J.L.; Guan, H.; Shang, F.J.; Niu, X.L.; He, Y.P.; Lu, X.L.
Chymase induces profibrotic response via transforming growth factor-beta1/Smad activation in rat cardiac fibroblasts
Mol. Cell. Biochem.
310
159-166
2008
Rattus norvegicus
Manually annotated by BRENDA team
Reimer, J.M.; Enoksson, M.; Samollow, P.B.; Hellman, L.
Extended substrate specificity of opossum chymase - Implications for the origin of mast cell chymases
Mol. Immunol.
45
2116-2125
2008
Monodelphis domestica
Manually annotated by BRENDA team
Andersson, M.K.; Pemberton, A.D.; Miller, H.R.; Hellman, L.
Extended cleavage specificity of mMCP-1, the major mucosal mast cell protease in mouse - High specificity indicates high substrate selectivity
Mol. Immunol.
45
2548-2558
2008
Mus musculus
Manually annotated by BRENDA team
Andersson, M.K.; Karlson, U.; Hellman, L.
The extended cleavage specificity of the rodent beta-chymases rMCP-1 and mMCP-4 reveal major functional similarities to the human mast cell chymase
Mol. Immunol.
45
766-775
2008
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Miyazaki, M.; Takai, S.; Jin, D.; Muramatsu, M.
Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models
Pharmacol. Ther.
112
668-676
2006
Canis lupus familiaris, Homo sapiens, Mesocricetus auratus
Manually annotated by BRENDA team
Wang, Y.; Gu, Y.; Zhang, Y.; Lewis, D.F.; Alexander, J.S.; Granger, D.N.
Increased chymotrypsin-like protease (chymase) expression and activity in placentas from women with preeclampsia
Placenta
28
263-269
2007
Homo sapiens
Manually annotated by BRENDA team
Vaali, K.; Puumalainen, T.J.; Lehto, M.; Wolff, H.; Rita, H.; Alenius, H.; Palosuo, T.
Murine model of food allergy after epicutaneous sensitization: role of mucosal mast cell protease-1
Scand. J. Gastroenterol.
41
1405-1413
2006
Mus musculus
Manually annotated by BRENDA team
Chen, W.; Yu, M.H.; Li, Y.M.; Chen, W.J.; Xia, Y.P.
Beneficial effects of astragalus polysaccharides treatment on cardiac chymase activities and cardiomyopathy in diabetic hamsters
Acta Diabetol.
47 Suppl. 1
35-46
2010
Mesocricetus auratus
Manually annotated by BRENDA team
Inoue, N.; Muramatsu, M.; Jin, D.; Takai, S.; Hayashi, T.; Katayama, H.; Kitaura, Y.; Tamai, H.; Miyazaki, M.
Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice
Atherosclerosis
204
359-364
2008
Mus musculus
Manually annotated by BRENDA team
Belkowski, S.M.; Masucci, J.; Mahan, A.; Kervinen, J.; Olson, M.; de Garavilla, L.; DAndrea, M.R.
Cleaved SLPI, a novel biomarker of chymase activity
Biol. Chem.
389
1219-1224
2008
Homo sapiens
Manually annotated by BRENDA team
Prosser, H.C.; Forster, M.E.; Richards, A.M.; Pemberton, C.J.
Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: effects of PA12 upon cardiac haemodynamics
Cardiovasc. Res.
82
40-50
2009
Rattus norvegicus
Manually annotated by BRENDA team
Terakawa, M.; Fujieda, Y.; Tomimori, Y.; Muto, T.; Tanaka, T.; Maruoka, H.; Nagahira, K.; Ogata, A.; Nakatsuka, T.; Fukuda, Y.
Oral chymase inhibitor SUN13834 ameliorates skin inflammation as well as pruritus in mouse model for atopic dermatitis
Eur. J. Pharmacol.
601
186-191
2008
Mus musculus
Manually annotated by BRENDA team
Cristovam, P.C.; Arnoni, C.P.; de Andrade, M.C.; Casarini, D.E.; Pereira, L.G.; Schor, N.; Boim, M.A.
ACE-dependent and chymase-dependent angiotensin II generation in normal and glucose-stimulated human mesangial cells
Exp. Biol. Med.
233
1035-1043
2008
Homo sapiens
Manually annotated by BRENDA team
Magnusson, S.E.; Pejler, G.; Kleinau, S.; Abrink, M.
Mast cell chymase contributes to the antibody response and the severity of autoimmune arthritis
FASEB J.
23
875-882
2009
Mus musculus
Manually annotated by BRENDA team
Wong, C.K.; Ng, S.S.; Lun, S.W.; Cao, J.; Lam, C.W.
Signalling mechanisms regulating the activation of human eosinophils by mast-cell-derived chymase: implications for mast cell-eosinophil interaction in allergic inflammation
Immunology
126
579-587
2009
Homo sapiens
Manually annotated by BRENDA team
Andersson, M.K.; Enoksson, M.; Gallwitz, M.; Hellman, L.
The extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile
Int. Immunol.
21
95-104
2009
Homo sapiens
Manually annotated by BRENDA team
Firth, J.D.; Uitto, V.J.; Putnins, E.E.
Mechanical induction of an epithelial cell chymase associated with wound edge migration
J. Biol. Chem.
283
34983-34993
2008
Homo sapiens
Manually annotated by BRENDA team
Sugimoto, M.; Furuta, T.; Kodaira, C.; Nishino, M.; Yamade, M.; Ikuma, M.; Sugimura, H.; Hishida, A.
Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan
J. Gastroenterol.
43
751-761
2008
Homo sapiens
Manually annotated by BRENDA team
Hossny, E.M.; Amr, N.H.; Elsayed, S.B.; Nasr, R.A.; Ibraheim, E.M.
Association of polymorphisms in the mast cell chymase gene promoter region (-1903 g/A) and (TG)n(GA)m repeat downstream of the gene with bronchial asthma in children
J. Investig. Allergol. Clin. Immunol.
18
376-381
2008
Homo sapiens
Manually annotated by BRENDA team
Guillabert, A.; Wittamer, V.; Bondue, B.; Godot, V.; Imbault, V.; Parmentier, M.; Communi, D.
Role of neutrophil proteinase 3 and mast cell chymase in chemerin proteolytic regulation
J. Leukoc. Biol.
84
1530-1538
2008
Homo sapiens
Manually annotated by BRENDA team
Simard, E.; Jin, D.; Takai, S.; Miyazaki, M.; Brochu, I.; DOrleans-Juste, P.
Chymase-dependent conversion of Big endothelin-1 in the mouse in vivo
J. Pharmacol. Exp. Ther.
328
540-548
2009
Mus musculus
Manually annotated by BRENDA team
Amano, N.; Takai, S.; Jin, D.; Ueda, K.; Miyazaki, M.
Possible roles of mast cell-derived chymase for skin rejuvenation
Lasers Med. Sci.
24
223-229
2009
Mesocricetus auratus
Manually annotated by BRENDA team
McEuen, A.R.; Walls, A.F.
Purification and characterization of mast cell tryptase and chymase from human tissues
Methods Mol. Med.
138
299-317
2008
Homo sapiens
Manually annotated by BRENDA team
Togawa, H.; Nakanishi, K.; Shima, Y.; Obana, M.; Sako, M.; Nozu, K.; Tanaka, R.; Iijima, K.; Yoshikawa, N.
Increased chymase-positive mast cells in children with crescentic glomerulonephritis
Pediatr. Nephrol.
24
1071-1075
2009
Homo sapiens
Manually annotated by BRENDA team
DOrleans-Juste, P.; Houde, M.; Rae, G.A.; Bkaily, G.; Carrier, E.; Simard, E.
Endothelin-1 (1-31): from chymase-dependent synthesis to cardiovascular pathologies
Vascul. Pharmacol.
49
51-62
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Belkowski, S.M.; Boot, J.D.; Mascelli, M.A.; Diamant, Z.; de Garavilla, L.; Hertzog, B.; Polkovitch, D.; Towers, M.; Batheja, A.; DAndrea, M.R.
Cleaved secretory leucocyte protease inhibitor as a biomarker of chymase activity in allergic airway disease
Clin. Exp. Allergy
39
1179-1186
2009
Homo sapiens
Manually annotated by BRENDA team
Tashiro, K.; Takai, S.; Jin, D.; Yamamoto, H.; Komeda, K.; Hayashi, M.; Tanaka, K.; Tanigawa, N.; Miyazaki, M.
Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet
Hepatol. Res.
40
514-523
2010
Mesocricetus auratus
Manually annotated by BRENDA team
Wei, C.C.; Hase, N.; Inoue, Y.; Bradley, E.W.; Yahiro, E.; Li, M.; Naqvi, N.; Powell, P.C.; Shi, K.; Takahashi, Y.; Saku, K.; Urata, H.; Dellitalia, L.J.; Husain, A.
Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents
J. Clin. Invest.
120
1229-1239
2010
Mus musculus
Manually annotated by BRENDA team
Chen, W.; Li, Y.M.; Yu, M.H.
Astragalus polysaccharides inhibited diabetic cardiomyopathy in hamsters depending on suppression of heart chymase activation
J. Diabetes Complicat.
24
199-208
2010
Mesocricetus auratus
Manually annotated by BRENDA team
Takai, S.; Jin, D.; Ohzu, M.; Tanaka, K.; Miyazaki, M.
Chymase inhibition provides pancreatic islet protection in hamsters with streptozotocin-induced diabetes
J. Pharmacol. Sci.
110
459-465
2009
Mesocricetus auratus
Manually annotated by BRENDA team
Kawarai, S.; Masuda, K.; Ohmori, K.; Matsuura, S.; Yasuda, N.; Nagata, M.; Sakaguchi, M.; Tsujimoto, H.
Cultivation and characterization of canine skin-derived mast cells
J. Vet. Med. Sci.
72
131-140
2010
Canis lupus familiaris
Manually annotated by BRENDA team
Bot, I.; Bot, M.; van Heiningen, S.H.; van Santbrink, P.J.; Lankhuizen, I.M.; Hartman, P.; Gruener, S.; Hilpert, H.; van Berkel, T.J.; Fingerle, J.; Biessen, E.A.
Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE-/- mice
Cardiovasc. Res.
89
244-252
2011
Homo sapiens
Manually annotated by BRENDA team
Andersson, M.K.; Thorpe, M.; Hellman, L.
Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2 of substrates
FEBS J.
277
2255-2267
2010
Homo sapiens
Manually annotated by BRENDA team
Korkmaz, B.; Jegot, G.; Lau, L.C.; Thorpe, M.; Pitois, E.; Juliano, L.; Walls, A.F.; Hellman, L.; Gauthier, F.
Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates
FEBS J.
278
2635-2646
2011
Homo sapiens
Manually annotated by BRENDA team
Gallwitz, M.; Enoksson, M.; Thorpe, M.; Ge, X.; Hellman, L.
The extended substrate recognition profile of the dog mast cell chymase reveals similarities and differences to the human chymase
Int. Immunol.
22
421-431
2010
Canis lupus familiaris
Manually annotated by BRENDA team
Akahoshi, M.; Song, C.H.; Piliponsky, A.M.; Metz, M.; Guzzetta, A.; Abrink, M.; Schlenner, S.M.; Feyerabend, T.B.; Rodewald, H.R.; Pejler, G.; Tsai, M.; Galli, S.J.
Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice
J. Clin. Invest.
121
4180-4191
2011
Mus musculus
Manually annotated by BRENDA team
Piliponsky, A.M.; Chen, C.C.; Rios, E.J.; Treuting, P.M.; Lahiri, A.; Abrink, M.; Pejler, G.; Tsai, M.; Galli, S.J.
The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis
Am. J. Pathol.
181
875-886
2012
Mus musculus (P21812), Mus musculus
Manually annotated by BRENDA team
Nabe, T.; Kijitani, Y.; Kitagawa, Y.; Sakano, E.; Ueno, T.; Fujii, M.; Nakao, S.; Sakai, M.; Takai, S.
Involvement of chymase in allergic conjunctivitis of guinea pigs
Exp. Eye Res.
113
74-79
2013
Cavia porcellus (A7WPL7), Cavia porcellus
Manually annotated by BRENDA team
Kosanovic, D.; Dahal, B.K.; Wygrecka, M.; Reiss, I.; Guenther, A.; Ghofrani, H.A.; Weissmann, N.; Grimminger, F.; Seeger, W.; Schermuly, R.T.; Banat, G.A.
Mast cell chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis?
Histol. Histopathol.
28
691-699
2013
Rattus norvegicus
Manually annotated by BRENDA team
Dong, X.; Zhang, C.; Ma, S.; Wen, H.
Mast cell chymase in keloid induces profibrotic response via transforming growth factor-beta1/Smad activation in keloid fibroblasts
Int. J. Clin. Exp. Pathol.
7
3596-3607
2014
Homo sapiens
Manually annotated by BRENDA team
Roy, A.; Ganesh, G.; Sippola, H.; Bolin, S.; Sawesi, O.; Dagaelv, A.; Schlenner, S.M.; Feyerabend, T.; Rodewald, H.R.; Kjellen, L.; Hellman, L.; Abrink, M.
Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation
J. Biol. Chem.
289
237-250
2014
Homo sapiens (P23946), Homo sapiens, Mus musculus (P21812), Mus musculus
Manually annotated by BRENDA team
Reber, L.L.; Daubeuf, F.; Pejler, G.; Abrink, M.; Frossard, N.
Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism
J. Immunol.
192
1847-1854
2014
Mus musculus (P21812), Mus musculus
Manually annotated by BRENDA team
Houde, M.; Jamain, M.D.; Labonte, J.; Desbiens, L.; Pejler, G.; Gurish, M.; Takai, S.; DOrleans-Juste, P.
Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1
J. Pharmacol. Exp. Ther.
346
31-37
2013
Mus musculus (P21812), Mus musculus
Manually annotated by BRENDA team
Takai, S.; Jin, D.; Miyazaki, M.
Multiple mechanisms for the action of chymase inhibitors
J. Pharmacol. Sci.
118
311-316
2012
Homo sapiens (P23946)
Manually annotated by BRENDA team
Beghdadi, W.; Madjene, L.C.; Claver, J.; Pejler, G.; Beaudoin, L.; Lehuen, A.; Daugas, E.; Blank, U.
Mast cell chymase protects against renal fibrosis in murine unilateral ureteral obstruction
Kidney Int.
84
317-326
2013
Mus musculus (P21812), Mus musculus
Manually annotated by BRENDA team
Dong, X.; Chen, J.; Zhang, Y.; Cen, Y.
Mast cell chymase promotes cell proliferation and expression of certain cytokines in a dose-dependent manner
Mol. Med. Rep.
5
1487-1490
2012
Homo sapiens (P23946), Homo sapiens
Manually annotated by BRENDA team
Waern, I.; Lundequist, A.; Pejler, G.; Wernersson, S.
Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation
Mucosal Immunol.
6
911-920
2013
Mus musculus (P21812), Mus musculus
Manually annotated by BRENDA team
de Souza, D.A.; Toso, V.D.; Campos, M.R.; Lara, V.S.; Oliver, C.; Jamur, M.C.
Expression of mast cell proteases correlates with mast cell maturation and angiogenesis during tumor progression
PLoS ONE
7
e40790
2012
Mus musculus, Mus musculus (P21812)
Manually annotated by BRENDA team
Ahooghalandari, P.; Hanke, N.; Thorpe, M.; Witte, A.; Messinger, J.; Hellman, L.
Mutations in Arg143 and Lys192 of the human mast cell chymase markedly affect the activity of five potent human chymase inhibitors
PLoS ONE
8
e65988
2013
Homo sapiens (P23946), Homo sapiens
Manually annotated by BRENDA team
Smith, E.T.; Perry, E.T.; Sears, M.B.; Johnson, D.A.
Expression of recombinant human mast cell chymase with Asn-linked glycans in glycoengineered Pichia pastoris
Protein Expr. Purif.
102
69-75
2014
Homo sapiens
Manually annotated by BRENDA team
Wang, Y.; Shi, G.P.
Mast cell chymase and tryptase in abdominal aortic aneurysm formation
Trends Cardiovasc. Med.
22
150-155
2012
Homo sapiens (P23946), Homo sapiens
Manually annotated by BRENDA team
Dubey, A.; Marabotti, A.; Ramteke, P.W.; Facchiano, A.
Interaction of human chymase with ginkgolides, terpene trilactones of Ginkgo biloba investigated by molecular docking simulations
Biochem. Biophys. Res. Commun.
473
449-454
2016
Homo sapiens (P23946), Homo sapiens
Manually annotated by BRENDA team
Chu, Y.; Wang, J.; Zhou, X.
Mast cell chymase in synovial fluid of collagen-induced-arthritis rats regulates gelatinase release and promotes synovial fibroblasts proliferation via FAK/p21 signaling pathway
Biochem. Biophys. Res. Commun.
514
336-343
2019
Rattus norvegicus
Manually annotated by BRENDA team
de Souza Junior, D.A.; Santana, A.C.; da Silva, E.Z.; Oliver, C.; Jamur, M.C.
The role of mast cell specific chymases and tryptases in tumor angiogenesis
BioMed Res. Int.
2015
142359
2015
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Futamura-Takahashi, J.; Tanaka, T.; Sugawara, H.; Iwashita, S.; Imajo, S.; Oyama, Y.; Muto, T.
Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors
Bioorg. Med. Chem. Lett.
28
188-192
2018
Homo sapiens (P23946), Homo sapiens
Manually annotated by BRENDA team
Lipitsae, T.; Siiskonen, H.; Naukkarinen, A.; Harvima, I.T.
Mast cell chymase degrades fibrinogen and fibrin
Br. J. Dermatol.
181
296-303
2019
Homo sapiens
Manually annotated by BRENDA team
Fu, Z.; Akula, S.; Thorpe, M.; Chahal, G.; de Garavilla, L.; Kervinen, J.; Hellman, L.
Extended cleavage specificity of sheep mast cell protease-2 A classical chymase with preference to aromatic P1 substrate residues
Dev. Comp. Immunol.
92
160-169
2019
Ovis aries (P79204), Ovis aries
Manually annotated by BRENDA team
Gendrin, C.; Shubin, N.J.; Boldenow, E.; Merillat, S.; Clauson, M.; Power, D.; Doran, K.S.; Abrink, M.; Pejler, G.; Rajagopal, L.; Piliponsky, A.M.
Mast cell chymase decreases the severity of group B Streptococcus infections
J. Allergy Clin. Immunol.
142
120-129.e6
2018
Mus musculus
Manually annotated by BRENDA team
Sansoe, G.; Aragno, M.; Mastrocola, R.; Mengozzi, G.; Novo, E.; Parola, M.
Role of chymase in the development of liver cirrhosis and its complications experimental and human data
PLoS ONE
11
e0162644
2016
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Thorpe, M.; Fu, Z.; Albat, E.; Akula, S.; de Garavilla, L.; Kervinen, J.; Hellman, L.
Extended cleavage specificities of mast cell proteases 1 and 2 from golden hamster Classical chymase and an elastolytic protease comparable to rat and mouse MCP-5
PLoS ONE
13
e0207826
2018
Mesocricetus auratus
Manually annotated by BRENDA team
Chang, H.; Sun, Y.; Yeh, F.; Tseng, I.; Chang, C.; Lin, C.
Detection of chymase activity using a specific peptide probe conjugated onto gold nanoparticles
RSC Adv.
8
29013-29021
2018
Homo sapiens
-
Manually annotated by BRENDA team