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2-hydroxyethyl (4R)-4-[4-cyanophenyl-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]]-1,2,3,4-tetrahydropyrimidine-5-carboxylate
-
GW475151
suicide inhibitor
human pancreatic secretory trypsin inhibitor
variants optimized with respect to the affinity and specificity for human leukocyte elastase relative to trypsin, and in particular chymotrypsin
-
MDL101146
suicide inhibitor
MeO-Suc-Ala-Ala-Pro-Ala-CH2Cl
MeO-Suc-Ala-Ala-Pro-Val-CH2Cl
methoxysuccinyl-Ala-Ala-Pro-Val-CH2Cl
-
methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone
-
N2-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoyl]-N-(2-propylphenyl)-L-leucinamide
-
((6R,7S)-2-{[(2S)-2-(dihydroxymethyl)pyrrolidin-1-yl]carbonyl}-7-methoxy-5,5-dioxido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl acetate
-
-
(-)-epigallocatechin-3-gallate
-
-
(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methyl 2,6-dichlorobenzoate
-
-
(1-{1-Methyl-2-oxo-2-[2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidin-1-yl]-ethylcarbamoyl}-ethyl)-carbamic acid benzyl ester
-
-
(1-{2-[1-(4,5-Dihydro-oxazole-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid benzyl ester
-
-
(1-{2-[1-(Benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid benzyl ester
-
-
(1-{2-[1-(Benzooxazole-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid benzyl ester
-
-
(1-{2-[2-(3,3-Difluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethylcarbamoyl}-ethyl)-carbamic acid benzyl ester
-
-
(1-{[1-(2-tert-Butoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-amino}-2-methyl-propyl)-phosphonic acid diphenyl ester
-
-
(2-(3,5-bis-trifluoromethyl-phenyl)-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(2-(3,5-difluoro-phenyl)-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(2-(4-amino-phenyl)-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(2-(4-chloro-phenyl)-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(2-(4-formylamino-phenyl)-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(2-(4-methoxy-phenyl)-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(2-(4-nitro-phenyl)-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(2-cyclohexyl-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(2-isopropyl-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(22E,24R)-ergosta-7,22-dien-2alpha,3alpha,9alpha-triol
-
-
(2R, 3R)-6-methyl-3'-geranyl-2,3-trans-5,7,4'-trihydroxyflavonol
-
-
(2S)-1-({(6R,7S)-3-[(acetyloxy)methyl]-7-methoxy-5,5-dioxido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl}carbonyl)pyrrolidine-2-carboxylic acid
-
-
(3-methylindazol-1-yl)-m-tolyl-methanone
-
-
(3beta,5alpha,8alpha,22E)-ergosta-6,22-diene-3-ol-5,8-peroxide
-
-
(3beta,5alpha,8alpha,22E)-ergosta-6,22-diene-3-ol-5,8-peroxide 3-O-beta-D-glucoside
-
-
(3R)-1-[3-(5-ethyl-7-methoxy-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperidine-3-carboxylic acid
-
-
(3S)-1-[3-(5-ethyl-7-methoxy-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperidine-3-carboxylic acid
-
-
(4-tert-butyl-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methyl 2,6-dichlorobenzoate
-
-
(5-Benzyloxycarbonylamino-1-{2-methyl-1-[2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-pentyl)-carbamic acid benzyl ester
-
-
(5E)-3-benzyl-5-but-2-ynylidenedihydrofuran-2(3H)-one
-
-
(5E)-3-benzyl-5-prop-2-ynylidenedihydrofuran-2(3H)-one
-
-
(5E)-3-butyl-5-prop-2-ynylidenedihydrofuran-2(3H)-one
-
-
(5E)-5-prop-2-ynylidenedihydrofuran-2(3H)-one
-
-
(5Z)-3-benzyl-5-prop-2-ynylidenedihydrofuran-2(3H)-one
-
-
(6-oxo-2-(4-fluorophenyl)-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(6-oxo-2-phenyl-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(6-oxo-2-pyridin-3-yl-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(6-oxo-2-thiophen-2-yl-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(6-oxo-2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(6E)-3-benzyl-6-prop-2-ynylidenetetrahydro-2H-pyran-2-one
-
-
(6E)-6-(1-bromoethylidene)-3-isopropyltetrahydro-2H-pyran-2-one
-
-
(6E)-6-(bromomethylene)-3-isopropyltetrahydro-2H-pyran-2-one
-
-
(6R,7S)-3-[(acetyloxy)methyl]-7-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5,5-dioxide
-
-
(6Z)-3-benzyl-6-prop-2-ynylidenetetrahydro-2H-pyran-2-one
-
-
(6Z)-6-(bromomethylene)-3-isopropyltetrahydro-2H-pyran-2-one
-
-
(E)-3-(3-(3,7-dimethylocta-2,6-dienyl)-2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chroman-4-one
-
competitive inhibitor
(E)-6-O-p-coumaroyl scandoside methyl ester
-
an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant
(E)-6-O-p-feruloyl scandoside methyl ester
-
an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant
(E)-6-O-p-methoxycinnamoyl scandoside methyl ester
-
an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant. Molecular docking simulation and structural model for the inhibition of human neutrophil elastase, overview
(R)-3-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1lambda6-1,2-benzisothiazol-2-yl-methanesulfonylamino)-propionic acid methyl ester
-
-
(S)-1-[(S)-2-(4-methoxybenzamido)-3-methylbutyryl]-N-[(S)-2-methyl-1-(trifluoroacetyl)propyl]pyrrolidine-2-carboxamide
-
-
(S)-3-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1lambda6-1,2-benzisothiazol-2-yl-methanesulfonylamino)-propionic acid methyl ester
-
-
(Z)-6-O-p-coumaroyl scandoside methyl ester
-
an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant
(Z)-6-O-p-methoxycinnamoyl scandoside methyl ester
-
an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant
1(6H)-Pyrimidineacetamide, 2-(4-aminophenyl)-5-[(methylsulfonyl)amino]-6-oxo-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
-
-
1(6H)-Pyrimidineacetamide, 2-(4-fluorophenyl)-5-(methylamino)-6-oxo-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
-
-
1(6H)-Pyrimidineacetamide, 5-(ethylamino)-6-oxo-2-(2-thienyl)-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
-
-
1(6H)-Pyrimidineacetamide, 5-(formylamino)-6-oxo-2-(2-thienyl)-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
-
-
1(6H)-Pyrimidineacetamide, 5-amino-2-(4-fluorophenyl)-N-[2-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]-6-oxo-
-
-
1(6H)-Pyrimidineacetamide, 5-amino-N-[2-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]-6-oxo-2-(2-thienyl)-
-
-
1(6H)-Pyrimidineacetamide, 5-[[(cyclohexylamino)sulfonyl]amino]-2-(4-fluorophenyl)-N-[2-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]-6-oxo-
-
-
1(6H)-Pyrimidineacetamide, 6-oxo-2-phenyl-5-[(trifluoroacetyl)amino]-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
-
-
1,2,5-thiadiazolidin-3-one 1,1-dioxide
-
the inhibitor causes rapid, time-dependent, irreversible loss of enzymatic activity
1-(2-((1-methyl-1H-imidazol-2-ylthio)methyl)phenyl)-3,3-diethylazetidine-2,4-dione
-
-
1-(2-((5-phenyl-1,3,4-oxadiazol-2-ylthio)methyl)phenyl)-3,3-diethylazetidine-2,4-dione
-
-
1-(2-((benzo[d]oxazol-2-ylthio)methyl)phenyl)-3,3-diethylazetidine-2,4-dione
-
-
1-(2-((benzo[d]thiazol-2-ylthio)methyl)phenyl)-3,3-diethylazetidine-2,4-dione
-
-
1-(2-Acetylamino-propionyl)-pyrrolidine-2-carboxylic acid (3-chloro-1-methyl-2-oxo-propyl)-amide
-
-
1-(2-methylbenzoyl)-1H-indazole-3-carboxylic acid phenylamide
-
-
1-(3-aminobenzoyl)-1H-indazole-3-carboxylic acid ethyl ester
-
-
1-(3-aminobenzoyl)-1H-indazole-3-carboxylic acid phenylamide
-
-
1-(3-methoxybenzoyl)-1H-indazole-3-carboxylic acid ethyl ester
-
-
1-(3-methoxybenzoyl)-1H-indazole-3-carboxylic acid methyl ester
-
-
1-(3-methoxybenzoyl)-1H-indazole-3-carboxylic acid phenylamide
-
-
1-(3-methoxybenzoyl)-1H-indazole-3-carboxylic acid propyl ester
-
-
1-(3-methylbenzoyl)-1H-indazole-3-carboxylic acid methyl ester
-
-
1-(4-((5-phenyl-1,3,4-oxadiazol-2-ylthio)methyl)phenyl)-3,3-diethylazetidine-2,4-dione
-
-
1-(4-((benzo[d]oxazol-2-ylthio)methyl)phenyl)-3,3-diethylazetidine-2,4-dione
-
-
1-(4-((benzo[d]thiazol-2-ylthio)methyl)phenyl)-3,3-diethylazetidine-2,4-dione
-
-
1-(4-chlorophenyl)-3,3-diethylazetidine-2,4-dione
-
-
1-(4-chlorophenyl)-3,3-dimethylazetidine-2,4-dione
-
-
1-(4-cyanobenzoyl)-1H-indazole-3-carboxylic acid ethyl ester
-
-
1-(6-((benzo[d]thiazol-2-ylthio)methyl)pyridin-3-yl)-3,3-diethylazetidine-2,4-dione
-
-
1-(pyridine-4-carbonyl)-1H-indazole-3-carboxylic acid phenylamide
-
-
1-(thiophene-3-carbonyl)-1H-indazole-3-carboxylic acid ethyl ester
-
-
1-(thiophene-3-carbonyl)-1H-indazole-3-carboxylic acid methyl ester
-
-
1-(thiophene-3-carbonyl)-1H-indazole-3-carboxylic acid phenylamide
-
-
1-(thiophene-3-carbonyl)-1H-indazole-3-carboxylic acid propyl ester
-
-
1-benzoyl-1H-indazole-3-carboxylic acid methyl ester
-
-
1-benzoyl-1H-indazole-3-carboxylic acid phenylamide
-
-
1-benzyl-3,3-dimethylazetidine-2,4-dione
-
-
1-butyryl-1H-indazole-3-carboxylic acid ethyl ester
-
-
1-cyclopentanecarbonyl-1H-indazole-3-carboxylic acid ethyl ester
-
-
1-methyl-1H-tetrazole-5-thiol
-
-
1-propionyl-1H-indazole-3-carboxylic acid ethyl ester
-
-
1-[(3-chlorophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide
-
-
1-[(3-fluorophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide
-
-
1-[(3-methylphenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide
-
-
1-[(3-nitrophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide
-
-
1-[(4-chlorophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide
-
-
1-[(4-cyanophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide
-
-
1-[(4-fluorophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide
-
-
1-[(4-methylphenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide
-
-
1-[(methylsulfonyl)oxy]pyrrolidine-2,5-dione
-
-
1-[2-(2-Acetylamino-propionylamino)-propionyl]-pyrrolidine-2-carboxylic acid (3-chloro-1-isopropyl-2-oxo-propyl)-amide
-
-
1-[2-(2-Acetylamino-propionylamino)-propionyl]-pyrrolidine-2-carboxylic acid (3-chloro-1-methyl-2-oxo-propyl)-amide
-
-
1-[2-(4-Benzenesulfonylaminocarbonyl-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid (3,3-difluoro-1-isopropyl-2-oxo-3-phenethylcarbamoyl-propyl)-amide
-
-
1-[2-(chloromethyl)phenyl]-3,3-difluoroazetidin-2-one
-
-
1-[3-(5-cyclobutyl-7-methoxy-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperidine-4-carboxylic acid
-
-
1-[3-(5-cyclopropyl-7-methoxy-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperidine-4-carboxylic acid
-
-
1-[3-(5-ethyl-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperidine-4-carboxylic acid
-
-
1-[3-(5-ethyl-7-methoxy-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperidine-4-carboxylic acid
-
-
1-[3-(5-methyl-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperidine-4-carboxylic acid
-
-
1-[3-(7-methoxy-4-oxo-5-propyl-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperidine-4-carboxylic acid
-
-
1-[3-[7-methoxy-4-oxo-5-(propan-2-yl)-4H-3,1-benzoxazin-2-yl]pyridin-2-yl]piperidine-4-carboxylic acid
-
-
1-{2-[4-(4-Bromo-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-pyrrolidine-2-carboxylic acid (3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-amide
-
-
1-{2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-pyrrolidine-2-carboxylic acid (1-isopropyl-2,3-dioxo-heptyl)-amide
-
-
1-{2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-pyrrolidine-2-carboxylic acid (3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-amide
-
-
1-{3-Methyl-2-[(naphthalene-2-carbonyl)-amino]-butyryl}-pyrrolidine-2-carboxylic acid (1-isopropyl-2,3-dioxo-heptyl)-amide
-
-
1-{[({2-[3-(trifluoromethyl)phenyl]ethyl}amino)carbonyl]oxy}pyrrolidine-2,5-dione
-
-
14alpha-hydroxy-ergosta-4,7,9(11),22-tetraen-3,6-dione
-
-
1H-indazol-1-yl(3-methylphenyl)methanone
-
-
2,2,2-trifluoroethyl 1-(phenylcarbonyl)-1H-indazole-3-carboxylate
-
-
2,2,2-trifluoroethyl 1-(thiophen-3-ylcarbonyl)-1H-indazole-3-carboxylate
-
-
2,2,2-trifluoroethyl 1-[(3-aminophenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
2,2,2-trifluoroethyl 1-[(3-methoxyphenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
2,2,2-trifluoroethyl 1-[(3-methylphenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
2,2-Dimethyl-propionic acid 4-[2-(2,2-dihydroxy-ethylcarbamoyl)-benzenesulfonylamino]-phenyl ester
-
-
2,2-Dimethyl-propionic acid 4-[4-(2,2-dimethyl-propionyloxy)-benzoyl]-phenyl ester
-
-
2,3-dihydro-6-[3-(2-hydroxymethyl)-phenyl-2-propenyl]5-benzofuranol
-
the synthetic inhibitor may provide a new and useful therapeutic for the treatment of diseases characterized by polymorphonuclear elastase involvement
2-(2,4-dinitrophenyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
-
-
2-(2-ethylbutanoyl)-1,2-benzisothiazol-3(2H)-one
-
-
2-(2-furoyl)-1,2-benzisothiazol-3(2H)-one
-
-
2-(2-furoyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
-
-
2-(2-methoxypyridin-3-yl)-5-methyl-4H-3,1-benzoxazin-4-one
-
-
2-(2-phenoxypyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
2-(2-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]pyridin-3-yl)-5-ethyl-7-methoxy-4H-3,1-benzoxazin-4-one
-
-
2-(2-[[2-(dimethylamino)ethyl](methyl)amino]pyridin-3-yl)-5-methyl-4H-3,1-benzoxazin-4-one
-
-
2-(2-[[2-(dimethylamino)ethyl]amino]pyridin-3-yl)-5-methyl-4H-3,1-benzoxazin-4-one
-
-
2-(3,3,3-Trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester
-
-
2-(3-trifluoromethylphenylamino)-4H-thieno[2,3-d][1,3]oxazin-4-one
-
-
2-(4-(3,3-diethyl-2,4-dioxoazetidin-1-yl)benzylthio)benzo[d ]-oxazole-6-carboxylic acid
-
-
2-(4-Chloro-benzenesulfonylamino)-5,5-dihydroxy-pentanoic acid (2-isopropylamino-5-methyl-4-oxo-4H-benzo[d][1,3]oxazin-7-yl)-amide
-
-
2-(4-Dihydroxymethyl-phenoxy)-3,3-diethyl-4-oxo-azetidine-1-carboxylic acid 4-methyl-benzylamide
-
-
2-(5-amino-6-oxo-2-thien-2-ylpyrimidin-1(6H)-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide
-
-
2-(chloromethyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
-
-
2-(thiophen-2-ylcarbonylthio)-N-(2-oxo-2,3,4,5-tetrahydrothiophen-3-yl)propionamide
-
reversible, slow-binding, fully competitive
2-(trifluoromethyl)-4H-3,1-benzoxazin-4-one
-
-
2-Acetylamino-N-(1-ethylcarbamoyl-ethyl)-propionamide
-
-
2-Acetylamino-N-[1-(3-chloro-1-methyl-2-oxo-propylcarbamoyl)-ethyl]-propionamide
-
-
2-Acetylamino-N-[2-(2-{2-[(2-chloro-acetyl)-isopropyl-amino]-acetyl}-pyrrolidin-1-yl)-1-methyl-2-oxo-ethyl]-propionamide
-
-
2-Acetylamino-N-{1-[1-(3-chloro-1-methyl-2-oxo-propylcarbamoyl)-ethylcarbamoyl]-ethyl}-propionamide
-
-
2-amino-4H-3,1-benzoxazin-4-one
-
-
2-amino-5-ethyl-4H-3,1-benzoxazin-4-one
-
-
2-benzoyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
-
-
2-CF3CF2C(O)NH-C6H4-SO2-F
-
-
2-chloro-4-(1-hydroxyoctadecyl)benzoic acid
-
SC-39026, reversible non-competitive inhibition at low concentrations (0.0005-0.00125 mM), mixed type inhibition at higher concentrations
2-ethoxy-4H-3,1-benzoxazin-4-one
-
-
2-ethoxy-5-ethyl-4H-3,1-benzoxazin-4-one
-
-
2-methyl-4H-3,1-benzoxazin-4-one
-
-
2-nitrophenylboronic acid
-
-
2-[(Imidazole-1-carbonyl)-amino]-pentanoic acid methyl ester
-
-
2-[2-(1H-imidazol-1-yl)pyridin-3-yl]-5-methyl-4H-3,1-benzoxazin-4-one
-
-
2-[2-(4-butylpiperazin-1-yl)pyridin-3-yl]-5-ethyl-7-methoxy-4H-3,1-benzoxazin-4-one
-
-
2-[2-(4-cyclopentylpiperazin-1-yl)pyridin-3-yl]-5-ethyl-7-methoxy-4H-3,1-benzoxazin-4-one
-
-
2-[2-(4-fluorophenyl)-6-oxo-5-[(cyclohexylsulfamoyl)-amino]-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide
-
-
2-[2-[4-(cyclopropylmethyl)piperazin-1-yl]pyridin-3-yl]-5-ethyl-7-methoxy-4H-3,1-benzoxazin-4-one
-
-
2-[4-(2,2-Dihydroxy-ethyl)-phenoxy]-3,3-diethyl-4-oxo-azetidine-1-carboxylic acid (1-benzo[1,3]dioxol-5-yl-butyl)-amide
-
-
2-[4-(2,2-Dihydroxy-ethyl)-phenoxy]-3,3-diethyl-4-oxo-azetidine-1-carboxylic acid (1-p-tolyl-butyl)-amide
-
-
2-[4-(2,2-Dihydroxy-ethyl)-phenoxy]-3,3-diethyl-4-oxo-azetidine-1-carboxylic acid 4-methyl-benzylamide
-
-
2-[5-amino-2-(3,5-difluorophenyl)-6-oxopyrimidin-1(6H)-yl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide
-
-
2-[5-amino-6-oxo-2-(2-thienyl)-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide
-
-
2-[5-amino-6-oxo-2-(4-fluorophenyl)-1,6-dihydro-1-pyrimidinyl]-N-[2-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]acetamide
-
-
2-[5-[(benzyloxycarbonyl)amino]-6-oxo-2-(2-thienyl)-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide
-
-
2-[benzyloxycarbonyl-NHCH2-C(O)NH]-C6H4-SO2-F
-
-
3'-geranyl-5,7,2',4'-tetrahydroxyisoflavanone
-
-
3,3-diethyl-1-(4-((phenylthio)methyl)phenyl)azetidine-2,4-dione
-
-
3,3-diethyl-1-(4-methoxyphenyl)azetidine-2,4-dione
-
-
3,3-diethyl-1-(4-methylphenyl)azetidine-2,4-dione
-
-
3,3-diethyl-1-(6-methylpyridin-3-yl)azetidine-2,4-dione
-
-
3,3-diethyl-1-(naphthalen-1-yl)azetidine-2,4-dione
-
-
3,3-diethyl-1-(pyridin-3-yl)azetidine-2,4-dione
-
-
3,3-diethyl-1-o-tolylazetidine-2,4-dione
-
-
3,3-diethyl-1-phenylazetidine-2,4-dione
-
-
3,3-diethyl-1-[4-(naphthalen-2-yloxy)phenyl]azetidine-2,4-dione
-
-
3,3-dimethyl-1-phenylazetidine-2,4-dione
-
-
3,4-dichloro-1H-isochromen-1-one
-
-
3-acetoxymethyl-7-[S]-methoxy-8-oxo-5-thia-1-aza-6[R]-bicyclo[4.2.0]oct-2-ene-2-(2-(S)-carboxypyrrolidine-carboxamide)-5,5-dioxide
-
L-658,758, cephalosporin-based anti-elastase
3-benzyl-1-(sulfooxy)pyrrolidine-2,5-dione
-
-
3-benzyl-1-[(methylsulfonyl)oxy]pyrrolidine-2,5-dione
-
-
3-benzyl-1-{[(4-vinylphenyl)sulfonyl]oxy}pyrrolidine-2,5-dione
-
-
3-benzyl-3-ethyl-1-phenylazetidine-2,4-dione
-
-
3-benzyl-3-methyl-1-phenylazetidine-2,4-dione
-
-
3-CF3-C6H4-CO-Ala-Ala-4-nitroanilide
-
-
3-chloro-1H-isochromen-1-one
-
-
3-ethyl-3-isobutyl-1-phenylazetidine-2,4-dione
-
-
3-isopropyl-1-[(methylsulfonyl)oxy]pyrrolidine-2,5-dione
-
-
3-isopropyl-1-{[(4-vinylphenyl)sulfonyl]oxy}pyrrolidine-2,5-dione
-
-
3-isopropyl-6-methylenetetrahydro-2H-pyran-2-one
-
-
3-methoxy-1-oxo-1H-isochromen-7-yl nitrite
-
-
3-methoxy-7-nitro-1H-isochromen-1-one
-
-
3-tert-butyl-1-{[(4-vinylphenyl)sulfonyl]oxy}pyrrolidine-2,5-dione
-
-
3-[(1-{2-[2-(3-Methoxycarbonyl-propionylamino)-propionylamino]-propionyl}-pyrrolidine-2-carbonyl)-amino]-4-methyl-2-oxo-pentanoic acid methyl ester
-
-
3-[2-(2-Benzyloxycarbonylamino-propionylamino)-propionylamino]-2-oxo-pentanoic acid benzyl ester
-
-
3-[4-[3-(5-ethyl-7-methoxy-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperazin-1-yl]propanenitrile
-
-
3-{[1-(2-Benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-amino}-4-methyl-2-oxo-pentanoic acid ethyl ester
-
-
3beta,5alpha,9alpha-trihydroxy-ergosta-7,22-dien-6-one
-
-
3beta,5alpha-dihydroxy-6beta-methoxyergosta-7,22-diene
-
-
3beta,5alpha-dihydroxy-ergosta-7,22-dien-6-one
-
-
3beta-hydroxy-ergosta-7,22-dien-6-one
-
-
4-((1-(((1-(R)-(5-benzofuranyl)butyl)amino)carbonyl)-3,3-diethyl-4-oxo-2-(S)-azetidinyl)oxy)benzene acetic acid
-
the synthetic inhibitor may provide a new and useful therapeutic for the treatment of diseases characterized by polymorphonuclear elastase involvement
4-(3,3-diethyl-2,4-dioxoazetidin-1-yl)benzonitrile
-
-
4-(4-bromophenylsulfonylcarbamoyl)benzoyl-L-valyl-L-proline 1 (RS)-(1-trifluoroacetyl-2-methylpropyl)amide
-
ICI 200,355, reversible, tight, and potent inhibitor, prevents the ongoing destruction of insoluble elastin by elastase, IC50: 16 nM, 4fold excess of inhibitor over enzyme causes 83% inhibition
4-chloro-3-ethoxy-1H-isochromen-1-one
-
-
4-chloro-3-methoxy-1-oxo-1H-isochromen-7-yl nitrite
-
-
4-chloro-3-methoxy-7-nitro-1H-isochromen-1-one
-
-
4-[3-(5-ethyl-7-methoxy-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperazine-1-carboxylic acid
-
-
4-{5-(Adamantane-1-sulfonylamino)-6-oxo-6-[2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidin-1-yl]-hexylcarbamoyl}-butyric acid methyl ester
-
-
5,6-dimethyl-2-(4-nitrophenylamino)-4H-thieno[2,3-d][1,3]thioxazin-4-one
-
-
5-(2-Chloro-benzyl)-2-(2,2-dimethyl-propionyloxy)-5-hydroxy-5,6-dihydro-thieno[3,2-c]pyridin-5-ium; chloride
-
-
5-(4-Chloro-benzenesulfonylamino)-5-(2-isopropylamino-5-methyl-4-oxo-4H-benzo[d][1,3]oxazin-7-ylcarbamoyl)-pentyl-ammonium; chloride
-
-
5-aminopyridin-6-one-containing trifluoromethyl ketones
-
-
-
5-chloro-2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
5-chloro-2-(2-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
5-chloro-2-(2-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
5-chloro-2-(2-methoxyphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
5-chloro-2-(2-methylphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
5-chloro-2-(2-phenoxypyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
5-cyclobutyl-7-methoxy-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-cyclobutyl-7-methoxy-2-[2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-cyclopropyl-7-methoxy-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-cyclopropyl-7-methoxy-2-[2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-2-(isopropylamino)-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-2-methyl-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-2-[2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-2-[2-[4-(2-hydroxyethyl)piperazin-1-yl]pyridin-3-yl]-7-methoxy-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-7-methoxy-2-(2-[4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl]pyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-7-methoxy-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-7-methoxy-2-[2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-7-methoxy-2-[2-[4-(2-methoxyethyl)piperazin-1-yl]pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-7-methoxy-2-[2-[4-(2-methylpropyl)piperazin-1-yl]pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-methoxy-2-(2-phenoxypyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-(2-methylpyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-(2-phenoxy-pyridin-3-yl)-benzo[d][1,3]oxazin-4-one
-
development and synthesis, overview
5-methyl-2-(2-phenoxyphenyl)-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-(2-phenoxypyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-(2-[[2-(morpholin-4-yl)ethyl]amino]pyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-(6-methylpyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-(pyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-(trifluoromethyl)-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-[2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-tert-butyl-7-methoxy-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5alpha,6alpha,8alpha,9alpha-diepoxy-ergost-22-en-3beta,7alpha-diol
-
-
5alpha,6alpha-epoxy-ergosta-8(14),22-diene-3beta,7alpha-diol
-
-
5alpha,6alpha-epoxy-ergosta-8(9),22-dien-7-one-3beta-ol
-
-
6-({1-[2-(2-Benzyloxycarbonylamino-propionylamino)-propionyl]-pyrrolidine-2-carbonyl}-amino)-4,4-difluoro-5-oxo-heptanoic acid methyl ester
-
-
6-amino-2-(2,2,2-trifluoro-acetylamino)-hexanoic acid [1-(4-trifluoromethyl-phenylcarbamoyl)-ethyl]-amide
-
-
7-(4-chlorophenylsulfonyl-L-glutamyl)amino-5-methyl-2-iso-propylamino-4H-3,1-benzoxazin-4-one
-
TEI-5624, strong, highly specific inhibitor, prevents degradation of insoluble elastin by elastase
7-(4-chlorophenylsulfonyl-L-lysyl)amino-5-methyl-2-iso-propylamino-4H-3,1-benzoxazin-4-one
-
TEI-6344, strong, highly specific inhibitor, prevents degradation of insoluble elastin by elastase
7-(dimethylamino)-5-ethyl-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
7-(dimethylamino)-5-ethyl-2-[2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
7-amino-3-methoxy-1H-isochromen-1-one
-
-
7-amino-4-chloro-3-methoxy-1H-isochromen-1-one
-
-
7-chloro-2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
7-chloro-2-(2-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
7-chloro-2-(2-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
7-chloro-2-(2-methoxyphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
7-chloro-2-(2-methylphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
7-methoxy-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-5-(propan-2-yl)-4H-3,1-benzoxazin-4-one
-
-
7-methoxy-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-5-propyl-4H-3,1-benzoxazin-4-one
-
-
7-methoxy-2-[2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]pyridin-3-yl]-5-(propan-2-yl)-4H-3,1-benzoxazin-4-one
-
-
7-methoxy-2-[2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]pyridin-3-yl]-5-propyl-4H-3,1-benzoxazin-4-one
-
-
8-chloro-2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
8-chloro-2-(2-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
8-chloro-2-(2-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
8-chloro-2-(2-methoxyphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
8-chloro-2-(2-methylphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
Ac-Pro-Ala-Pro-NH2CH(CH3)CH2OH
-
-
Ac-Pro-Ala-Pro-NH2CH(CH3)CHO
-
-
Ac-Pro-Ala-Pro-NH2CH(CH3)CONH2
-
-
acetyl-Ala-Ala-Ala-Ala-CH2Cl
-
-
acetyl-Ala-Ala-Pro-Ala-CH2Cl
-
-
acetyl-Ala-Ala-Pro-Ile-CH2Cl
-
-
acetyl-Ala-Ala-Pro-Val-CH2Cl
-
-
alginate
-
weak inhibition, elastase molecule interacts with 19 uronic acid units of alginate
alpha-1-antichymotrypsin
-
-
-
alpha-1-protease inhibitor
-
also called alpha-1-antitrypsin
-
alpha-ketobenzoxazoles
-
-
-
Alpha1-proteinase inhibitor
-
-
-
alpha2-Macroglobulin
-
-
-
benzyl 3,3,3-trifluoro-1-isopropyl-2-oxopropylcarbamate
-
-
bis(2,3,5-trimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(2,3-dimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(2-methylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(3,4,5-trimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(3,4-dimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(3-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(3-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]propyl)phosphonate
-
-
bis(4-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(4-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]pentyl)phosphonate
-
-
bis(4-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]propyl)phosphonate
-
-
bis(4-ethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-methylpropyl)phosphonate
-
-
bis(4-ethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(4-ethylphenyl) (1-[[(benzyloxy)carbonyl]amino]butyl)phosphonate
-
-
bis(4-ethylphenyl) (1-[[(benzyloxy)carbonyl]amino]ethyl)phosphonate
-
-
bis(4-ethylphenyl) (1-[[(benzyloxy)carbonyl]amino]propyl)phosphonate
-
-
bis(4-methoxyphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-methylpropyl)phosphonate
-
-
bis(4-methoxyphenyl) (1-[[(benzyloxy)carbonyl]amino]pentyl)phosphonate
-
-
bis(4-methoxyphenyl) (1-[[(benzyloxy)carbonyl]amino]propyl)phosphonate
-
-
bis(4-methylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(4-tert-butylphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-methylpropyl)phosphonate
-
-
bis(4-tert-butylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(4-tert-butylphenyl) (1-[[(benzyloxy)carbonyl]amino]ethyl)phosphonate
-
-
bis(4-tert-butylphenyl) (1-[[(benzyloxy)carbonyl]amino]pentyl)phosphonate
-
-
bis[3-(methylsulfanyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis[4-(methylsulfanyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-2-methylpropyl)phosphonate
-
-
bis[4-(methylsulfanyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis[4-(methylsulfanyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]butyl)phosphonate
-
-
bis[4-(methylsulfanyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]ethyl)phosphonate
-
-
bis[4-(methylsulfanyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]propyl)phosphonate
-
-
bis[4-(propan-2-yl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis[4-(propan-2-yl)phenyl] (1-[[(benzyloxy)carbonyl]amino]ethyl)phosphonate
-
-
bis[4-(propan-2-yl)phenyl] (1-[[(benzyloxy)carbonyl]amino]pentyl)phosphonate
-
-
bis[4-(propan-2-yl)phenyl] (1-[[(benzyloxy)carbonyl]amino]propyl)phosphonate
-
-
Boc-Ala-Pro-isobutyl-boronic acid amide
-
-
Butyric acid 3-(3-bromomethylene-6-isopropyl-5-oxo-[1,4]dioxan-2-yl)-pyrrolidin-1-yl ester
-
-
Carbamic acid, [1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]ethyl]-2-(2-thienyl)-5-pyrimidinyl]-, 1-methylethyl ester
-
-
Carbamic acid, [1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]ethyl]-2-(2-thienyl)-5-pyrimidinyl]-, 2,2,2-trifluoroethyl ester
-
-
Carbamic acid, [1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]ethyl]-2-(2-thienyl)-5-pyrimidinyl]-, methyl ester
-
-
Carbamic acid, [1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]-, 2,2,2-trifluoroethyl ester
-
-
Carbamic acid, [2-(4-fluorophenyl)-1,6-dihydro-1-[2-[[2-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]amino]-2-oxoethyl]-6-oxo-5-pyrimidinyl]-, (3,5-dimethyl-4-pyridinyl)methyl ester
-
-
Carbamic acid, [2-(4-fluorophenyl)-1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]ethyl]-5-pyrimidinyl]-, 2-pyridinylmethyl ester
-
-
Carbamic acid, [2-(4-fluorophenyl)-1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]ethyl]-5-pyrimidinyl]-, 4-pyridinylmethyl ester
-
-
Carbamothioic acid, [1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]-, S-methyl ester
-
-
Carbamothioic acid, [2-(4-fluorophenyl)-1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]ethyl]-5-pyrimidinyl]-, S-methyl ester
-
-
CBZ-Ala-(isobutyl-difluoro-boron)amide
-
-
CBZ-Ala-isobutyl-boronic acid amide
-
-
ceftazidime
-
slight inhibition of purified elastase
cephalotin
-
IC50: 0.00025 mg/ml
CF3-CO-Ala-Ala-4-nitroanilide
-
-
CF3-CO-Ala-Ala-Ala-OH
-
-
clitocybin D
-
4-(4,6-dihydroxy-3-methoxy-3Hisoindol-1-yl)-benzoic acid, isolated from mycelia culture broth of Clitocybe aurantiaca, structure determination by NMR and mass spectroscopy
difluoro-beta-ketoamides
-
-
-
difluoromethyleneamines
-
-
-
diisopropyl phosphorofluoridate
-
-
dimethyl 3,3'-[[(1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphoryl]bis(oxy)]dibenzoate
-
-
dimethyl 4,4'-[[(1-[[(benzyloxy)carbonyl]amino]-2-methylpropyl)phosphoryl]bis(oxy)]dibenzenesulfinate
-
-
dimethyl 4,4'-[[(1-[[(benzyloxy)carbonyl]amino]-2-methylpropyl)phosphoryl]bis(oxy)]dibenzoate
-
-
dimethyl 4,4'-[[(1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphoryl]bis(oxy)]dibenzoate
-
-
dimethyl 4,4'-[[(1-[[(benzyloxy)carbonyl]amino]butyl)phosphoryl]bis(oxy)]dibenzoate
-
-
dimethyl 4,4'-[[(1-[[(benzyloxy)carbonyl]amino]ethyl)phosphoryl]bis(oxy)]dibenzoate
-
-
dimethyl 4,4'-[[(1-[[(benzyloxy)carbonyl]amino]pentyl)phosphoryl]bis(oxy)]dibenzoate
-
-
dimethyl 4,4'-[[(1-[[(benzyloxy)carbonyl]amino]propyl)phosphoryl]bis(oxy)]dibenzoate
-
-
diphenyl (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
diphenyl (1-[[(benzyloxy)carbonyl]amino]butyl)phosphonate
-
-
diphenyl (1-[[(benzyloxy)carbonyl]amino]ethyl)phosphonate
-
-
diphenyl (1-[[(benzyloxy)carbonyl]amino]pentyl)phosphonate
-
-
diphenyl (1-[[(benzyloxy)carbonyl]amino]propyl)phosphonate
-
-
elastase inhibitor III
-
-
-
EPI-hNE-4
-
potent and specific inhibitor of neutrohil elastase
-
EPI-hNE4 (depelstat)
-
-
-
epigallocatechin gallate
-
-
ergosta-4,7,22-trien-3,6-dione
-
-
ergosta-7,22-dien-2beta,3alpha,9alpha-triol
-
-
ergosta-7,22-dien-3beta,5alpha,6beta,9alpha-tetraol
-
-
erythromycin
-
acts as an alternate substrate neutrophil elastase inhibitor
ethyl (2S,3R)-2-[(2,2-dihydroxyethyl)sulfonyl]-3-ethyl-4-oxoazetidine-1-carboxylate
-
-
ethyl 1-(1,3-benzodioxol-5-ylcarbonyl)-1H-indazole-3-carboxylate
-
-
ethyl 1-(phenylcarbonyl)-1H-indazole-3-carboxylate
-
-
ethyl 1-acetyl-1H-indazole-3-carboxylate
-
-
ethyl 1-[(2-methylphenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
ethyl 1-[(3-chlorophenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
ethyl 1-[(3-fluorophenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
ethyl 1-[(3-methylphenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
ethyl 1-[(4-chlorophenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
ethyl 1-[(4-fluorophenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
ethyl 1-[(4-methylphenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
ethyl [4-(3,3-diethyl-2,4-dioxoazetidin-1-yl)phenyl]acetate
-
-
flurythromycin
-
inactivator of neutrophil elastase
Formic acid 2-(3-{1-[2-(N'-benzyloxycarbonyl-N'-propyl-hydrazinocarbonyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-ureido)-4-methyl-pentyl ester
-
-
Formic acid 4-methyl-2-(3-{2-methyl-1-[2-(N'-phenoxycarbonyl-N'-propyl-hydrazinocarbonyl)-pyrrolidine-1-carbonyl]-propyl}-ureido)-pentyl ester
-
-
gentamycin
-
slight inhibition of purified elastase
glutaryl-Ala-Ala-Pro-NH-C3H7
-
-
gold thiomalate
-
inhibition is abolished by 1.0 M KCl
greglin
-
fast-acting and tight-binding inhibitor of neutrophil elastase
-
GW447631
-
i.e. (3S,3aS,6aR)-4-(5-cyclopropylaminomethyl-pyrazine-2-carbonyl)-3-isopropyl-1-methanesulfonyl-hexahydropyrrolo[3,2-b]pyrrol-2-one hydrochloride
GW469002
-
i.e. (3S,3aS,6R)-4-[1-(2,2-dimethyl-propyl)azetidine-3-carbonyl]-3-isopropyl-1-methanesulfonyl-hexahydro-pyrrolo-[3,2-b]pyrrol-2-one
GW475151
-
i.e. (3S,3aS,6aR)-3-isopropyl-1-methanesulfonyl-4-(2-pyrrolidin-1-ylmethyl-oxazole-4-carbonyl)hexahydro-pyrrolo-[3,2-b]pyrrol-2-one hydrochloride
horse leukocyte elastase inhibitor
-
protein with a molecular weight of 35200 Da that forms sodium dodecylsulfate-stable equimolar complexes with elastase
-
human monocyte/neutrophil elastase inhibitor
-
effective inhibition
-
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[(1R)-3,3-difluoro-1-(1-methylethyl)-2,4-dioxo-4-[(2-pyridinylmethyl)amino]butyl]-
-
-
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[(1S)-3,3-difluoro-1-(1-methylethyl)-2,4-dioxo-4-[(2-pyridinylmethyl)amino]butyl]-
-
-
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[(1S)-3,3-difluoro-1-(1-methylethyl)-2-oxo-4-[(phenylmethyl)amino]butyl]-
-
-
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[(1S)-3,3-difluoro-4-(methylamino)-1-(1-methylethyl)-2,4-dioxobutyl]-
-
-
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[(1S)-4-(benzoylamino)-3,3-difluoro-1-(1-methylethyl)-2-oxobutyl]-
-
-
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[(1S)-4-amino-3,3-difluoro-1-(1-methylethyl)-2-oxobutyl]-
-
-
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[(1S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-3,3-difluoro-1-(1-methylethyl)-2-oxobutyl]-
-
-
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
-
-
L-Prolinamide, N-(phenoxycarbonyl)-L-valyl-N-[(1S)-3,3-difluoro-1-(1-methylethyl)-2,4-dioxo-4-[(2-pyridinylmethyl)amino]butyl]-
-
-
L-Prolinamide, N-(phenoxycarbonyl)-L-valyl-N-[(1S)-3,3-difluoro-4-(methylamino)-1-(1-methylethyl)-2,4-dioxobutyl]-
-
-
L-Prolinamide, N-(phenoxycarbonyl)-L-valyl-N-[(1S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-3,3-difluoro-1-(1-methylethyl)-2-oxobutyl]-
-
-
L-Prolinamide, N-(phenoxycarbonyl)-L-valyl-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
-
-
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3,3-difluoro-1-(1-methylethyl)-2-oxo-4-[(phenylmethyl)amino]butyl]-
-
-
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3,3-difluoro-4-(methylamino)-1-(1-methylethyl)-2,4-dioxobutyl]-
-
-
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-4-amino-3,3-difluoro-1-(1-methylethyl)-2,4-dioxobutyl]-
-
-
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-4-amino-3,3-difluoro-1-(1-methylethyl)-2-oxobutyl]-
-
-
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-3,3-difluoro-1-(1-methylethyl)-2-oxobutyl]-
-
-
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
-
-
leukocyte elastase inhibitor
-
long-chain fatty acids
-
-
m-CF3-C6H4-CO-Ala-Ala-4-nitroanilide
-
-
matrix metalloproteinase-7
-
human leukocyte elastase cleaves matrix metalloproteinase-7 resulting in loss of enzymatic activity
-
MCoTI-II K10A
-
a MCoTI-II exchange analogue
MCoTI-II K10F
-
a MCoTI-II exchange analogue
MCoTI-II K10V
-
a MCoTI-II exchange analogue
MeOSuc-Ala-Ala-Pro-Val-chloromethylketone
-
neutrophil elastase-specific inhibitor
methoxsuccinyl-Ala-Ala-Pro-Ile-boronic acid
-
-
methoxysuccinyl-Ala-Ala-Pro-(isobutyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)amide
-
-
methoxysuccinyl-Ala-Ala-Pro-isobutyl-boronic acid amide
-
-
methoxysuccinyl-Ala-Ala-Pro-phenylethylboronic acid
-
-
methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone
-
specific inhibitor
methoxysuccinyl-Ala-Ala-Pro-Val-CH2Cl
-
-
methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone
-
-
monocyte/neutrophil elastase inhibitor
-
i.e. MNEI, a 42 kDA serpin protein
-
N'-{1-[2-(2-Acetylamino-propionylamino)-propionyl]-pyrrolidine-2-carbonyl}-N-methyl-hydrazinecarboxylic acid 1-benzylcarbamoyl-ethyl ester
-
-
N'-{1-[2-(2-Acetylamino-propionylamino)-propionyl]-pyrrolidine-2-carbonyl}-N-methyl-hydrazinecarboxylic acid 1-carbamoyl-ethyl ester
-
-
N-(1-(1-[1-(4-benzoyl-phenylcarbamoyl)-2-methyl-propylcarbamoyl]-3-methyl-butylcarbamoyl)-2-(4-hydroxy-phenyl)-ethyl)-succinamic acid
-
-
N-(1-{1-Methyl-2-oxo-2-[2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidin-1-yl]-ethylcarbamoyl}-ethyl)-succinamic acid methyl ester
-
-
N-(1-{2-[2-(3-Chloro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethylcarbamoyl}-ethyl)-succinamic acid methyl ester
-
-
N-(1-{2-[2-(4-Ethoxy-3,3-difluoro-1-isopropyl-2-oxo-butylcarbamoyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethylcarbamoyl}-ethyl)-succinamic acid methyl ester
-
-
N-(2,2-diphenyl-ethyl)-1-(1,1,3-trioxo-1,3-dihydro-1lambda6-1,2-benzisothiazol-2-yl)-methanesulfonamide
-
-
N-(2-phenylethyl)-1H-imidazole-1-carboxamide
-
-
N-(5-(adamantane-1-sulfonylamino)-5-[1-(1-formyl-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-pentyl)-succinamic acid
-
-
N-(5-(adamantane-1-sulfonylamino)-5-[1-(1-formyl-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-pentyl)-terephthalamic acid
-
-
N-(5-benzyloxycarbonylamino-1-(1-[2-(1-formyl-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propylcarbamoyl)-pentyl)-succinamic acid
-
-
N-(methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone
N-([3-(carboxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]acetyl)-L-valyl-N-[(3R,S)1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]acetyl)-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]acetyl)-L-valyl-N-[(3S)-1-methoxy-4-methyl-1,2-dioxopentan-3-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2,4-dioxoimidazolidin-1-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2,5-dioxoimidazolidin-1-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2,6-dioxotetrahydropyrimidin-1(2H)-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2-oxoimidazolidin-1-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2-oxoimidazolidin-1-yl]acetyl)-L-valyl-N-[(3R)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2-oxoimidazolidin-1-yl]acetyl)-L-valyl-N-[(3S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]-L-prolinamide
-
i.e. AE-3763, it effects in lipopolysaccharide-induced lung injury model of lung edema and leukocyte infiltration, overveiw
N-([3-(carboxymethyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([4-(carboxymethoxy)phenoxy]acetyl)-L-valyl-N-[(benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([4-(carboxymethyl)-2,3-dioxopiperazin-1-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([4-(carboxymethyl)-2,3-dioxopiperazin-1-yl]acetyl)-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-prolinamide
-
-
N-([4-(carboxymethyl)-2,3-dioxopiperazin-1-yl]acetyl)-L-valyl-N-[(3S)-1-methoxy-4-methyl-1,2-dioxopentan-3-yl]-L-prolinamide
-
-
N-([4-(carboxymethyl)-2,5-dioxopiperazin-1-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([4-(carboxymethyl)-3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([4-(carboxymethyl)-6-methyl-3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([4-(carboxymethyl)piperazin-1-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-benzyl-1-(1,1,3-trioxo-1,3-dihydro-1lambda6-1,2-benzisothiazol-2-yl)-methanesulfonamide
-
-
N-galloyl-4-alkyliden-beta-lactam
-
a beta-lactam with an N-linked galloyl moiety, specific noncompetitive inhibition of the enzyme, but not affecting chemotactic response and viability of polymorphonuclear leukocytes, synthesis and structure, overview
N-methoxysuccinyl-Ala-Ala-Pro-Ala chloromethylketone
-
irreversible inhibitor
-
N-methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone
-
-
N-phenethyl-1-(1,1,3-trioxo-1,3-dihydro-1lambda6-1,2-benzisothiazol-2-yl)-methanesulfonamide
-
-
N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-valyl-N-[(3R,S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]-L-prolinamide
-
-
N-{1-[2-(2-{2-[(2-Chloro-acetyl)-isopropyl-amino]-acetyl}-pyrrolidin-1-yl)-1-methyl-2-oxo-ethylcarbamoyl]-ethyl}-succinamic acid
-
-
N-{1-[2-(2-{2-[(2-Chloro-acetyl)-isopropyl-amino]-acetyl}-pyrrolidin-1-yl)-1-methyl-2-oxo-ethylcarbamoyl]-ethyl}-succinamic acid methyl ester
-
-
N-{1-[2-(2-{2-[Isopropyl-(4-nitro-phenoxycarbonyl)-amino]-acetyl}-pyrrolidin-1-yl)-1-methyl-2-oxo-ethylcarbamoyl]-ethyl}-succinamic acid methyl ester
-
-
N-{2-[3-(trifluoromethyl)phenyl]ethyl}-1H-imidazole-1-carboxamide
-
-
N-{5-(Adamantane-1-sulfonylamino)-5-[1-(1-formyl-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-pentyl}-4-dihydroxymethyl-benzamide
-
-
NaCl
-
1.0 M, 50% inhibition
nigranoic acid
-
significant inhibitory activity
oleoyl-Ala-Ala-Pro-Ala
-
-
oleoyl-Ala-Ala-Pro-Val
-
-
pancreatic secretory trypsin inhibitor
-
variants of human secretory trypsin inhibitor are constructed with the aim of producing inhibitors specific for human leukocyte elastase. Models of the human pancreatic secretory trypsin inhibitor/human leukocytic elastase and human pancreatic secretory trypsin inhibitor/chymotrypsin complexes are generated by computer aided protein design and used to plan better human leukocyte elastase inhibitors. The native human pancreatic secretory trypsin inhibitor with Lys in position P1 (amino acid 18) is a highly potent inhibitor for trypsin and completely inactive towards chymotrypsin and elastase like proteinases. Replacing the Lys in P1 by Leu (pancreatic secretory trypsin inhibitor 7) causes a drastic change of the specificity : this variant no longer inhibits trypsin-like enzymes but is an excellent inhibitor of chymotrypsin and human leukocytic elastase
-
phenylmethylsulfonyl fluoride
-
-
polysaccharide sulfates
-
-
-
propan-2-yl 1-(phenylcarbonyl)-1H-indazole-3-carboxylate
-
-
propan-2-yl 1-(thiophen-3-ylcarbonyl)-1H-indazole-3-carboxylate
-
-
propan-2-yl 1-[(3-aminophenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
propan-2-yl 1-[(3-methoxyphenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
propan-2-yl 1-[(3-methylphenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
propolis
-
IC50: 0.002 mg dry weight per ml for ethyl acetate extract of propolis
-
propyl 1-(phenylcarbonyl)-1H-indazole-3-carboxylate
-
-
propyl 1-[(3-aminophenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
propyl 1-[(3-methylphenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
secretory leukocyte protease inhibitor
-
-
-
secretory leukoprotease inhibitor
-
-
-
secretory leukoproteinase inhibitor
-
important inhibitor of neutrophil elastase
-
semisynthetic glucan sulfates
-
with pullulan as basic polysaccharide: PulS1, PulS2, PulS3 (IC50: 0.0000181 mM), PulS4, PulS5, PulS6 and PulS7, with glucuronoxylan as basic polysaccharide: PPS, and with phycarine as basic polysaccharide: PS3
-
serum leukocyte protease inhibitor
-
-
-
sivelestat sodium
-
neutrophil elastase specific inhibitor
sivelestat sodium hydrate
SSR69071
-
i.e. 2-(9-(2-piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3-one-1,1-dioxide, a selective, orally active, and potent inhibitor of leukocyte elastase with good penetration in respiratory tissues
succinyl-Ala-Ala-Pro-Val-CH2Cl
-
-
succinyl-Tyr-D-Leu-D-Val-4-nitroanilide
-
-
tert-butoxycarbonyl-Val-Val-Val-NH-(CH2)11-CH3
-
-
tert-butyl (6R,7S)-3-[(acetyloxy)methyl]-7-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5,5-dioxide
-
-
tert-butyl (6R,7S)-3-[(acetyloxy)methyl]-7-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5,5-dioxide
-
-
thieno[2,3-d]-1,3-oxazin-4-ones
-
-
thieno[2,3-d]-1,3-thioxazin-4-ones
-
-
thieno[3,2-d]-1,3-oxazin-4-ones
-
-
thieno[3,2-d]-1,3-thioxazin-4-ones
-
-
tobramycin
-
slight inhibition of purified elastase
trifluoromethylketones
-
-
ZD0892
-
synthetic neutrophil elastase inhibitor
[(4S)-5-benzyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-(4-benzoylphenyl)propanoate
-
-
[(4S)-5-benzyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-(4-phenoxyphenyl)propanoate
-
-
[(4S)-5-benzyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-(acetyloxy)benzoate
-
-
[(4S)-5-benzyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-hydroxybenzoate
-
-
[(4S)-5-benzyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-[4-(propan-2-yl)phenyl]propanoate
-
-
[(4S)-5-benzyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 3-phenylpropanoate
-
-
[(4S)-5-benzyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl phenylacetate
-
-
[(4S)-5-benzyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl [2-[(2,6-dichlorophenyl)amino]phenyl]acetate
-
-
[(4S)-5-methyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-(4-benzoylphenyl)propanoate
-
-
[(4S)-5-methyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-(4-phenoxyphenyl)propanoate
-
-
[(4S)-5-methyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-(acetyloxy)benzoate
-
-
[(4S)-5-methyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-hydroxybenzoate
-
-
[(4S)-5-methyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-[4-(propan-2-yl)phenyl]propanoate
-
-
[(4S)-5-methyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 3-phenylpropanoate
-
-
[(4S)-5-methyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl phenylacetate
-
-
[(4S)-5-methyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl [2-[(2,6-dichlorophenyl)amino]phenyl]acetate
-
-
[({(2R,3S)-3-ethyl-1-[(4-methylphenyl)sulfonyl]-4-oxoazetidin-2-yl}carbonyl)oxy]acetic acid
-
-
[6-Oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-2-(4-trifluoromethyl-phenyl)-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester
-
-
{(6R,7S)-2-[(tert-butylamino)carbonyl]-7-methoxy-5,5-dioxido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl}methyl acetate
-
-
{1-[2-(1-Acetyl-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid benzyl ester
-
-
{1-[2-(1-Aminooxalyl-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid benzyl ester
-
-
{1-[2-(1-Formyl-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid benzyl ester
-
-
{1-[2-(1-Isopropyl-2,3-dioxo-heptylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid benzyl ester
-
-
{1-[2-(3,3-Difluoro-1-isopropyl-2,4-dioxo-7-phenyl-heptylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid benzyl ester
-
-
{1-[2-(3-Benzylcarbamoyl-3,3-difluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid benzyl ester
-
-
{2-Methyl-1-[(R)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-carbamic acid benzyl ester
-
-
{2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-carbamic acid benzyl ester
-
-
{2-Methyl-1-[2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-carbamic acid benzyl ester
-
-
{2-Methyl-1-[2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-carbamic acid benzyl ester
-
-
MeO-Suc-Ala-Ala-Pro-Ala-CH2Cl
-
MeO-Suc-Ala-Ala-Pro-Ala-CH2Cl
suicide inhibitor
MeO-Suc-Ala-Ala-Pro-Val-CH2Cl
-
MeO-Suc-Ala-Ala-Pro-Val-CH2Cl
suicide inhibitor
alpha-1-antitrypsin
-
-
-
alpha-1-antitrypsin
-
incomplete inhibition with the antielastase alpha-1-antitrypsin after binding to heparan sulfate components of syndecan-1
-
alpha-1-antitrypsin
-
neutrophil elastase is inactivated by 0.005 mg of alpha-1-antitrypsin for 30 min
-
alpha1-antitrypsin
-
-
-
alpha1-antitrypsin
-
very potent inhibitor, complete inhibition at nanomolar concentrations, colistin is unable to reverse inhibition
-
alpha1-antitrypsin
-
physiological inhibitor of neutrophil elastase. HL-60 cells neutralize neutrophil elastase activity by concomitant secretion of alpha1-antitrypsin
-
Eglin c
-
-
Eglin c
-
at a therapeutic concentration of 0.0005 mM eglin c will inhibit leukocyte elastase in one second and will bind this enzyme in a pseudo-irreversible manner
Eglin c
-
inhibition by a synthetic trihexacontapeptide corresponding to the sequence 8-70 of eglin c, no inhibition by a synthetic nonapeptide corresponding to the sequence 41-19 of eglin c
elafin
-
-
-
elafin
-
complete inhibition at 0.01 mM
-
elafin
-
a potent, substratelike, but fully reversible inhibitor
-
elafin
-
also known as elastase specific inhibitor, skin-derived antileukoprotease, or trappin-2
-
elafin
-
cationic protease inhibitor of human neutrophil elastase
-
elafin
-
substrate inhibitor of neutrophil elastase, the purified fragments of the cleaved inhibitor elafin, Lys6-Gln57 and Ser10-Gln57, are also still active for inhibiting neutrophil elastase
-
heparin
-
strong inhibition, partly reversible by addition of colistin
heparin
-
tight-binding non-competitive inhibitor, 90% inhibition at 0.5 ng/ml, higher chain length of oligosaccharides causes stronger inhibition, desulfated heparins lack inhibitory potential, ionic strength above 0.5 abolishes the inhibitory capacity of heparin
heparin
-
low molecular weight and semi-synthetic heparin samples with homogeneous degree of polymerization and saccharide backbone, mixed hyperbolic binding process, sulfation patterns, overview
leukocyte elastase inhibitor
-
-
-
leukocyte elastase inhibitor
-
i.e. LEI, inhibits leukocyte elastase, and also influences the automodification of poly(ADP-ribose) polymerase-1, PARP-1, which does not influence the inhibition of elastase by LEI, overview
-
N-(methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone
-
-
N-(methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone
-
complete inhibition at low micromolar concentrations, colistin is unable to reverse the complete inhibition with 0.005 mM but able to reverse the partial inhibition with 0.0005 mM N-(methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone
ovomucoid
-
chicken ovomucoid
-
ovomucoid
-
turkey ovomucoid
-
sivelestat
-
-
sivelestat
-
also known as Elaspol, a synthetic inhibitor of neutrophil elastase with high specificity
sivelestat
-
selective neutrophil elastase inhibitor
sivelestat
-
a selective neutrophil elastase inhibitor
sivelestat
-
a specific inhibitor of neutrophil elastase, it reduces the risk for ling dysfunction in patients after undergoing on-pump coronary artery bypass surgery, clinical study, overview
sivelestat
-
inhibits the enzyme and reduces brain edema and vascular permeability , and subsequently improves the neurological deficits in an acute focal ischemia. The inhibitor rescues the cultured endothelial cells from neutrophil elastase-induced damage. It can protect the blood-brain barrier function in acute cerebral ischemia
sivelestat
-
ONO-5046, competitive and selective inhibitor
sivelestat sodium hydrate
-
a selective inhibitor of neutrophil elastase, the compound is effective in reducing acute lung injury associated with systemic inflammatory response syndrome, SIRS. In patients with thoracic esophageal cancer undergoing thoracoscopic esophagectomy with extended lymph node dissection, the inhibitor treatment prevents postoperative hypercytokinemia and hypoxia secondary to SIRS in a clinical study, overview
sivelestat sodium hydrate
-
i.e. sodium N-[2-w4-(2,2-dimethylpropionyloxy) phenylsulfonylaminox benzoyl] aminoacetate tetrahydrate, a polymorphonuclear neutrophil elastase inhibitor. It may attenuate neutrophil elastase or proinflammatory cytokines, and improve pulmonary dysfunction in patients undergoing a cardiopulmonary bypass and aortic valve replacement
sivelestat sodium hydrate
-
ONO-5046, selective inhibitor
Trypsin inhibitor
-
soya-bean trypsin inhibitor
-
Trypsin inhibitor
-
lima-bean trypsin inhibitor
-
ursolic acid
-
IC50: 0.0337
ursolic acid
-
highest inhibitory potency
additional information
-
peptidyl trifluoromethyl ketone inhibitors can achieve high levels of oral activity and bioavailibility, and therefore they may prove useful as therapeutic agents in the treatment of diseases in which elastase is implicated
-
additional information
-
shows no activity as inhibitor
-
additional information
-
an imbalance between neutrophil elastase and its inhibitors in blood is related to the development of acute respiratory distress syndrome
-
additional information
-
budlein A inhibits neutrophil elastase release from neutrophils at 0.01683 mM for formylated bacterial tripeptide-induced release and at 0.01184 mM for platelet aggregation factor-induced release
-
additional information
-
extracts from 12 Arnica species show inhibition of 10-97% for platelet-activating factor-induced neutrophil elastase release and 1-100% for N-formyl-L-methionyl-L-leucyl-L-phenylalanine-induced neutrophil elastase release from neutrophils
-
additional information
-
neither leupeptin, E-64, pepstatin A, benzamidine, soybean trypsin inhibitor, Nalpha-tosyl-L-lysine chloromethyl ketone, N-p-tosyl-L-phenylalanine chloromethyl ketone, EDTA, GM6001, nor phosphoramidon have any inhibitory effect
-
additional information
-
2-[2-(4-methyl-piperazin-1-yl)-pyridin-3-yl] derivative inhibitor development and synthesis, structure-activity relationship study, overview
-
additional information
-
4-oxo-beta-lactams are selective and potent inhibitors of leukocyte elastase, 4-oxo-beta-lactams containing a heteroarylthiomethyl group on the para position of an N1-aryl moiety afforded highly potent and selective inhibition of the enzyme, even at a very low inhibitor to enzyme ratio, structure-activity relationship analysis, inhibition mechanisms, molecular modelling, overview
-
additional information
-
MCoTI-II modification and engineering by active site loop exchanges and truncations develop analogues with potent activity against leukocyte elastase, overview. No inhibition by MCoTI-I and MCoTI-II, and by analogues MCoTI-II K10R, MCoTI-II K10Q, and by MCoTI-II truncation analogues
-
additional information
-
synthesis and evaluation of benzoxazinone derivatives, inhibitory effect on neutrophil elastase, and effects on enzyme release from FMLP-activated human neutrophils, overview
-
additional information
-
synthesis of a series of peptide-based transition-state human neutrophil elastase inhibitors with N-terminal acidic moieties, evaluation of in vitro and in vivo inhibitory activities, overview
-
additional information
-
neutrophil elastase is not inhibited by 4-aminobenzoic acid hydrazide
-
additional information
-
not inhibited by 1-(3-methylbenzoyl)-1H-indazole-3-carboxylic acid, (3-methoxyphenyl)-(3-methylindazol-1-yl)-methanone, 1-(pyridine-4-carbonyl)-1H-indazole-3-carboxylic acid ethyl ester, 1-(naphthalene-1-carbonyl)-1H-indazole-3-carboxylic acid ethyl ester, 1-(3,4,5-trimethoxybenzoyl)-1H-indazole-3-carboxylic acid ethyl ester, 1-(pyridine-4-carbonyl)-1H-indazole-3-carboxylic acid phenylamide, 1-(toluene-4-sulfonyl)-1H-indazole-3-carboxylic acid phenylamide, 1-(4-chlorobenzenesulfonyl)-1H-indazole-3-carboxylic acid phenylamide, 1-(4-chlorobenzyl)-1H-indazole-3-carboxylic acid phenylamide, 1-(4-chlorophenyl)-1H-indazole-3-carboxylic acid phenylamide, 1-(2-oxo-2-phenylethyl)-1H-indazole-3-carboxylic acid ethyl ester, 1-(4-chlorophenylcarbamoyl)-1H-indazole-3-carboxylic acid ethyl ester, and 1-(3-methoxyphenylcarbamoyl)-1H-indazole-3-carboxylic acid ethyl ester
-
additional information
-
not inhibited by dalbergioidin, 3(S)-2',4'-dihydroxy-5,5'-dimethoxy-(6'',6''-dimethylpyano)-(2'',3'':7,6)-isoflavan, myrsininone A, isosophoranone, myrsininone B, and 3'-geranyl-5,7,2',5'-tetrahydroxyisoflavone
-
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Abruptio Placentae
[The study on mechanism of abruptio placentae caused by chorioamnionitis]
Abscess
Early diagnosis of a pancreatic abscess in acute pancreatitis.
Abscess
Histochemical localization of neutral proteases released during development of rat periradicular lesion.
Abscess
Investigation of neutrophils in the gut lumen by assay of granulocyte elastase in whole-gut lavage fluid.
Abscess
Leukocyte elastase alpha 1-proteinase inhibitor complexes may diagnose pancreatic abscesses early.
Abscess
Levels of leukocyte proteases in plasma and peritoneal exudate in severe, acute pancreatitis.
Abscess
Uptake of immunoreactive leukocyte elastase-inhibitor complexes in macrophage-like cells in abscesses.
Acidosis
Pyrexia and acidosis act independently of neutrophil elastase reactive center loop cleavage to effect cortisol release from corticosteroid-binding globulin.
Acne Vulgaris
Altered Gene Expression in Acne Vulgaris Patients Treated by Oral Isotretinoin: A Preliminary Study.
Acquired Immunodeficiency Syndrome
How to spot cocaine-induced pseudovasculitis.
Acquired Immunodeficiency Syndrome
Spectrum of ELANE mutations in congenital neutropenia: a single-centre study in patients of Indian origin.
Acute Coronary Syndrome
In vitro and in vivo evidence for the role of elastase shedding of CD163 in human atherothrombosis.
Acute Coronary Syndrome
The effects of non-surgical periodontal therapy on neutrophil elastase and elastase alpha-1 proteinase inhibitor levels in GCF in periodontitis patients with or without acute coronary syndrome.
Acute Lung Injury
A comparison of alpha 1-proteinase inhibitor methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone and specific beta-lactam inhibitors in an acute model of human polymorphonuclear leukocyte elastase-induced lung hemorrhage in the hamster.
Acute Lung Injury
A neutrophil elastase inhibitor, sivelestat, improves leukocyte deformability in patients with acute lung injury.
Acute Lung Injury
A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1.
Acute Lung Injury
A novel oral neutrophil elastase inhibitor (ONO-6818) inhibits human neutrophil elastase-induced emphysema in rats.
Acute Lung Injury
Activation of MMP-9 by neutrophil elastase in an in vivo model of acute lung injury.
Acute Lung Injury
Activity-based Near-Infrared Fluorogenic Probe Enables In Vitro and In Vivo Profiling of Neutrophil Elastase.
Acute Lung Injury
Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice.
Acute Lung Injury
Alpha-1 Antitrypsin for COVID-19 Treatment: Dual Role in Antiviral Infection and Anti-Inflammation.
Acute Lung Injury
Beneficial effect of neutrophil elastase inhibitor on anti-Thy1.1 nephritis in rats.
Acute Lung Injury
Biochemical and pharmacological activities of SR 26831, a potent and selective elastase inhibitor.
Acute Lung Injury
Clinical utility of the neutrophil elastase inhibitor sivelestat for the treatment of acute respiratory distress syndrome.
Acute Lung Injury
Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats.
Acute Lung Injury
Continuous infusion of sivelestat sodium hydrate prevents lipopolysaccharide-induced intestinal paralysis and hypotension in conscious guinea-pigs.
Acute Lung Injury
Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters.
Acute Lung Injury
Detection of human neutrophil elastase by aptamer affinity capillary electrophoresis coupled with laser-induced fluorescence using specified site fluorescently labeled aptamer.
Acute Lung Injury
Direct interaction of ONO-5046 with human neutrophil elastase through ¹H NMR and molecular docking.
Acute Lung Injury
Early administration of sivelestat, the neutrophil elastase inhibitor, in adults for acute lung injury following gastric aspiration.
Acute Lung Injury
Effect of a neutrophil elastase inhibitor on acute lung injury after cardiopulmonary bypass.
Acute Lung Injury
Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury.
Acute Lung Injury
Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis.
Acute Lung Injury
Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs.
Acute Lung Injury
Effects of neutrophil elastase inhibitor on progression of acute lung injury after liver transplantation.
Acute Lung Injury
Effects of neutrophil elastase inhibitor on progression of acute lung injury following esophagectomy.
Acute Lung Injury
Effects of sivelestat treatment on acute lung injury in paraquat-intoxicated rats.
Acute Lung Injury
Effects of sivelestat, a new elastase inhibitor, on IL-8 and MCP-1 production from stimulated human alveolar epithelial type II cells.
Acute Lung Injury
Effects of the early administration of sivelestat sodium on bronchopulmonary dysplasia in infants: A retrospective cohort study.
Acute Lung Injury
Efficacy of early sivelestat administration on acute lung injury and acute respiratory distress syndrome.
Acute Lung Injury
Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters.
Acute Lung Injury
Endothelial cell xanthine oxidase-derived toxic oxygen metabolites contribute to acute lung injury from neutrophil elastase.
Acute Lung Injury
Evidence of increased matrix metalloproteinase-9 concentration in patients following cardiopulmonary bypass.
Acute Lung Injury
GAPDH/Siah1 cascade is involved in traumatic spinal cord injury and could be attenuated by sivelestat sodium.
Acute Lung Injury
Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19.
Acute Lung Injury
Inhaled neutrophil elastase inhibitor reduces oleic acid-induced acute lung injury in rats.
Acute Lung Injury
Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster.
Acute Lung Injury
Inhibition of neutrophil elastase contributes to attenuation of lipopolysaccharide-induced acute lung injury during neutropenia recovery in mice.
Acute Lung Injury
Leukocyte elastase: physiological functions and role in acute lung injury.
Acute Lung Injury
Near-infrared fluorescent probe with large stokes shift for detecting Human Neutrophil elastase in living cells.
Acute Lung Injury
Neutrophil azurophilic granule exocytosis is primed by TNF-? and partially regulated by NADPH oxidase.
Acute Lung Injury
Neutrophil elastase activity in acute lung injury and respiratory distress syndrome.
Acute Lung Injury
Neutrophil elastase activity in pulmonary venous blood during lung resection.
Acute Lung Injury
Neutrophil elastase ameliorates matrix metalloproteinase-9 to promote lipopolysaccharide-induced acute lung injury in mice 1.
Acute Lung Injury
Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics.
Acute Lung Injury
Neutrophil elastase and systemic inflammatory response syndrome in the initiation and development of acute lung injury among critically ill patients.
Acute Lung Injury
Neutrophil elastase as a predicting factor for development of acute lung injury.
Acute Lung Injury
Neutrophil elastase contributes to acute lung injury induced by bilateral nephrectomy.
Acute Lung Injury
Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study.
Acute Lung Injury
Neutrophil elastase inhibitor improves postoperative clinical courses after thoracic esophagectomy.
Acute Lung Injury
Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.
Acute Lung Injury
Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats.
Acute Lung Injury
Neutrophil elastase inhibitor reduces ventilation-induced lung injury via nuclear factor-?B and NF-?B repressing factor in mice.
Acute Lung Injury
Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model.
Acute Lung Injury
Neutrophil elastase inhibitors, SC-37698 and SC-39026, reduce endotoxin-induced lung dysfunction in awake sheep.
Acute Lung Injury
Neutrophils mediate acute lung injury in rabbits: role of neutrophil elastase.
Acute Lung Injury
Phospholipase A in acute lung injury after trauma and sepsis: its relation to the inflammatory mediators PMN-elastase, C3a, and neopterin.
Acute Lung Injury
Predictors of the therapeutic effect of sivelestat in patients with acute lung injury associated with systemic inflammatory response syndrome.
Acute Lung Injury
Prevention of leukocyte activation by the neutrophil elastase inhibitor, sivelestat, in the hepatic microcirculation after ischemia-reperfusion.
Acute Lung Injury
Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy.
Acute Lung Injury
Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer.
Acute Lung Injury
Protection against acute lung injury by intravenous or intratracheal pretreatment with EPI-HNE-4, a new potent neutrophil elastase inhibitor.
Acute Lung Injury
Protective effects of a selective neutrophil elastase inhibitor (sivelestat) on lipopolysaccharide-induced acute dysfunction of the pulmonary microcirculation.
Acute Lung Injury
Proteolytic inactivation of dog lung surfactant-associated proteins by neutrophil elastase.
Acute Lung Injury
Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study.
Acute Lung Injury
Relationship between neutrophil elastase and acute lung injury in humans.
Acute Lung Injury
Role of neutrophil elastase in lung injury induced by burn-blast combined injury in rats.
Acute Lung Injury
Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice.
Acute Lung Injury
Sivelestat relaxes porcine coronary artery via inhibition of Ca2+ sensitization induced by a receptor agonist.
Acute Lung Injury
Sivelestat relaxes vascular smooth muscle contraction in human gastric arteries.
Acute Lung Injury
Sivelestat sodium hydrate improves post-traumatic knee osteoarthritis through nuclear factor-?B in a rat model.
Acute Lung Injury
Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury.
Acute Lung Injury
Sivelestat, a specific neutrophil elastase inhibitor, prevented phorbol myristate acetate-induced acute lung injury in conscious rabbits.
Acute Lung Injury
Specific neutrophil elastase inhibitor does not attenuate acute lung injury induced by air embolism in awake sheep.
Acute Lung Injury
The effect of sivelestat sodium hydrate on severe respiratory failure after thoracic aortic surgery with deep hypothermia.
Acute Lung Injury
The effects of nitric oxide and peroxynitrite on interleukin-8 and elastase from lipopolysaccharide-stimulated whole blood.
Acute Lung Injury
The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study.
Acute Lung Injury
The involvement of nitric oxide, nitric oxide synthase, neutrophil elastase, myeloperoxidase and proinflammatory cytokines in the acute lung injury caused by phorbol myristate acetate.
Acute Lung Injury
The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury.
Acute Lung Injury
The role of neutrophil elastase in acute lung injury.
Acute Lung Injury
The Role of Neutrophil Elastase Inhibitors in Lung Diseases.
Acute Lung Injury
The use of neutrophil elastase inhibitor in the treatment of acute lung injury after pneumonectomy.
Acute Lung Injury
Urinary Trypsin Inhibitor Attenuates Seawater-Induced Acute Lung Injury by Influencing the Activities of Nuclear Factor-?B and Its Related Inflammatory Mediators.
Acute Lung Injury
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
Acute Lung Injury
[Acute lung injury and chemical mediators]
Acute Lung Injury
[Case of possible transfusion-related acute lung injury during thoracic endovascular aortic repair].
Acute Lung Injury
[Efficacy of sivelestat for acute lung injury due to severe bacterial pneumonia with systemic inflammatory response syndrome]
Acute Lung Injury
[Improvement in research on mechanisms of acute lung injury induced by neutrophil elastase.]
Acute Lung Injury
[New findings on the physiopathology of acute hemolytic transfusion reactions]
Acute Lung Injury
[Pathophysiology and treatment of postoperative acute respiratory disturbance]
Acute Lung Injury
[Pathophysiology of acute lung injury]
Acute Lung Injury
[Prognostic significance of neutrophil elastase inhibitor in patients with acute lung injury and interstitial pneumonia]
Acute Lung Injury
[Prophylactic effects of neutrophil elastase inhibitor for patients undergoing surgery for thoracic aortic aneurysm: a retrospective study]
Adenocarcinoma
Early detection of pancreatic cancers in liquid biopsies by ultrasensitive fluorescence nanobiosensors.
Adenocarcinoma
EGCG reverses human neutrophil elastase-induced migration in A549 cells by directly binding to HNE and by regulating ?1-AT.
Adenocarcinoma
Inhibition of Neutrophil Elastase and Metalloprotease-9 of Human Adenocarcinoma Gastric Cells by Chamomile (Matricaria recutita L.) Infusion.
Adenocarcinoma
Salivary Proteome and Peptidome Profiling in Type 1 Diabetes Mellitus Using a Quantitative Approach.
Adenocarcinoma of Lung
Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of ?1-antitrypsin in lung cancer.
Adenocarcinoma of Lung
Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth.
Agammaglobulinemia
Autosomal-dominant primary immunodeficiencies.
Aggressive Periodontitis
Neutrophils in chronic and aggressive periodontitis in interaction with Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.
Aggressive Periodontitis
Proinflammatory cytokines production and PMN-elastase release from activated PMN cells in the periodontal disease.
Aggressive Periodontitis
Serum and salivary matrix metalloproteinases, neutrophil elastase, myeloperoxidase in patients with chronic or aggressive periodontitis.
Agranulocytosis
Acute and chronic neutropenias. What is new?
Agranulocytosis
Can mutations in ELA2, neutrophil elastase expression or differential cell toxicity explain sulphasalazine-induced agranulocytosis?
Airway Obstruction
Increased Lung Catalase Activity Confers Protection Against Experimental RSV Infection.
alpha 1-Antitrypsin Deficiency
Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema.
alpha 1-Antitrypsin Deficiency
Discovery of alpha 1-antitrypsin deficiency.
alpha 1-Antitrypsin Deficiency
[Proteinases and antiproteinases: biomedical correlations]
Alveolar Bone Loss
Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis.
Alzheimer Disease
[Inflammatory markers in Alzheimer's disease and vascular dementia.]
Alzheimer Disease
[Quantification of the relationship between inflammatory markers and Alzheimer's disease].
Alzheimer Disease
[The use of cluster analysis and logistic regression for assessing the risk of Alzheimer's disease in patients with mild cognitive impairment, amnestic type].
Anemia
Local regulation of neutrophil elastase activity by endogenous ?1-antitrypsin in lipopolysaccharide-primed hematological cells.
Anemia, Diamond-Blackfan
Current insights into inherited bone marrow failure syndromes.
Anemia, Sickle Cell
Coexistence of sickle cell disease and severe congenital neutropenia: first impressions can be deceiving.
Anemia, Sickle Cell
Evaluation of Alpha-1 Antitrypsin Levels and
Anemia, Sickle Cell
Neutrophil extracellular trap regulators in sickle cell disease: Modulation of gene expression of PADI4, neutrophil elastase, and myeloperoxidase during vaso-occlusive crisis.
Aneurysm
Absence of plasma protease-antiprotease imbalance in the formation of saccular cerebral aneurysms.
Aneurysm
Human neutrophil elastase: mediator and therapeutic target in atherosclerosis.
Aneurysm
Magnetic resonance imaging assessment of proteolytic enzyme concentrations and biologic properties of intraluminal thrombus in abdominal aortic aneurysms.
Aneurysm
Neutrophil chemotaxis and neutrophil elastase in the aortic wall in patients with abdominal aortic aneurysms.
Aneurysm
Ruptured giant aneurysm of the left anterior descending coronary artery in Kawasaki disease.
Aneurysm
[Examination of elastase concentration in the wall of abdominal aortic aneurysms]
Aneurysm, Dissecting
Efficacy of neutrophil elastase inhibitor on type A acute aortic dissection.
Aneurysm, Dissecting
The effects of a neutrophil elastase inhibitor on the postoperative respiratory failure of acute aortic dissection.
Aneurysm, Ruptured
Absence of plasma protease-antiprotease imbalance in the formation of saccular cerebral aneurysms.
Angina, Stable
In vitro and in vivo evidence for the role of elastase shedding of CD163 in human atherothrombosis.
Angina, Stable
Neutrophil function in ischemic heart disease.
Angina, Unstable
Increased neutrophil elastase release in unstable angina pectoris and acute myocardial infarction.
Angina, Unstable
Neutrophil function in ischemic heart disease.
Anthrax
Neutrophil elastase and syndecan shedding contribute to antithrombin depletion in murine anthrax.
Anthrax
Neutrophil elastase mediates pathogenic effects of anthrax lethal toxin in the murine intestinal tract.
Anti-Glomerular Basement Membrane Disease
Strength of the pulmonary blood-gas barrier.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Cocaine-induced midline destruction.
Antithrombin III Deficiency
Application of argatroban, direct thrombin inhibitor, in heparin-intolerant patients requiring extracorporeal circulation.
Aortic Aneurysm
Source of elastin-degrading enzymes in mycotic aortic aneurysms: bacteria or host inflammatory response?
Aortic Aneurysm, Abdominal
Isoflavone Ameliorated Oxidative Stress and Vascular Damages in Nicotine-Administrated Mice.
Aortic Aneurysm, Abdominal
Neutrophil chemotaxis and neutrophil elastase in the aortic wall in patients with abdominal aortic aneurysms.
Aortic Aneurysm, Abdominal
Paradoxical neutrophil elastase release in endovascular abdominal aortic aneurysm repair.
Aortic Aneurysm, Abdominal
The calcium messenger system and the kinetics of elastase release from human neutrophils in patients with abdominal aortic aneurysms.
Aortic Aneurysm, Thoracic
[Prophylactic effects of neutrophil elastase inhibitor for patients undergoing surgery for thoracic aortic aneurysm: a retrospective study]
Arteritis
Human neutrophil elastase in temporal (giant cell) arteritis: plasma and immunohistochemical studies.
Arthritis
A Novel ELANE Mutation Associated with Inflammatory Arthritis, Defective NETosis, and Recurrent Parvoviral Infection.
Arthritis
Alpha-1-antitrypsin reduces inflammation and exerts chondroprotection in arthritis.
Arthritis
Binding characteristics of antitype II collagen antibody to the surface of diseased human cartilage as a probe for tissue damage.
Arthritis
Detection of human neutrophil elastase by aptamer affinity capillary electrophoresis coupled with laser-induced fluorescence using specified site fluorescently labeled aptamer.
Arthritis
Early cartilage degradation in cationic immune complex arthritis in mice: relative role of interleukin 1, the polymorphonuclear cell (PMN) and PMN elastase.
Arthritis
Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis.
Arthritis
Elevated Serum Concentrations of Polymorphonuclear Neutrophilic Leukocyte Elastase in Systemic Sclerosis: Association with Pulmonary Fibrosis.
Arthritis
Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: association with pulmonary fibrosis.
Arthritis
Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis.
Arthritis
MRP8/14 and neutrophil elastase for predicting treatment response and occurrence of flare in patients with juvenile idiopathic arthritis.
Arthritis
Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase-activated receptor-2.
Arthritis
Pathogenesis of antigen-induced arthritis in mice deficient in neutrophil elastase and cathepsin G.
Arthritis
Polymorphonuclear leukocyte elastase activity is increased by bacterial lipopolysaccharide: a response inhibited by glucocorticoids.
Arthritis, Experimental
Induction of pulmonary thromboembolism by neutrophil elastase in collagen-induced arthritis mice and effect of recombinant human soluble thrombomodulin.
Arthritis, Experimental
Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146.
Arthritis, Experimental
Suppressive effect of a neutrophil elastase inhibitor on the development of collagen-induced arthritis.
Arthritis, Infectious
PMN elastase in bone and joint infections.
Arthritis, Juvenile
MRP8/14 and neutrophil elastase for predicting treatment response and occurrence of flare in patients with juvenile idiopathic arthritis.
Arthritis, Rheumatoid
Anti-inflammatory activity of neutrophil elastase inhibitors.
Arthritis, Rheumatoid
Antineutrophil cytoplasmic antibodies in Bulgarian patients with rheumatoid arthritis: characterization and clinical associations.
Arthritis, Rheumatoid
Antineutrophil cytoplasmic antibodies: a still-growing class of autoantibodies in inflammatory disorders.
Arthritis, Rheumatoid
Biochemical and pharmacological activities of SR 26831, a potent and selective elastase inhibitor.
Arthritis, Rheumatoid
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Arthritis, Rheumatoid
Circulating inhibitor bound elastase in patients with ankylosing spondylitis and rheumatoid arthritis and the influence of sulphasalazine treatment.
Arthritis, Rheumatoid
Effect of piroxicam therapy on granulocyte function and granulocyte elastase concentration in peripheral blood and synovial fluid of rheumatoid arthritis patients.
Arthritis, Rheumatoid
Effective anticoagulation by argatroban during immunoadsorption therapy for malignant rheumatoid arthritis with a high polymorphonuclear leukocyte elastase level.
Arthritis, Rheumatoid
Fibrin degradation in the synovial fluid of rheumatoid arthritis patients: a model for extravascular fibrinolysis.
Arthritis, Rheumatoid
Induction of pulmonary thromboembolism by neutrophil elastase in collagen-induced arthritis mice and effect of recombinant human soluble thrombomodulin.
Arthritis, Rheumatoid
Inhibition of human leukocyte elastase by chemically and naturally oversulfated galactosaminoglycans.
Arthritis, Rheumatoid
Inhibition of neutrophil elastase by the alpha1-proteinase inhibitor-immunoglobulin A complex.
Arthritis, Rheumatoid
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Arthritis, Rheumatoid
Measurement of plasma concentrations of polymorphonuclear elastase-alpha 1 proteinase inhibitor (elastase-alpha 1 antitrypsin) in patients with rheumatoid arthritis: interference by rheumatoid factor.
Arthritis, Rheumatoid
Neutrophil elastase and cathepsin G: structure, function, and biological control.
Arthritis, Rheumatoid
Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.
Arthritis, Rheumatoid
ONO-6818 Cortech/Ono.
Arthritis, Rheumatoid
Phosphonic pseudopeptides as human neutrophil elastase inhibitors--a combinatorial approach.
Arthritis, Rheumatoid
Plasma lactoferrin and neutrophil elastase in rheumatoid arthritis and systemic lupus erythematosus.
Arthritis, Rheumatoid
Propeptide glycosylation and galectin-3 binding decrease proteolytic activation of human proMMP-9/progelatinase B.
Arthritis, Rheumatoid
Proteolytic cleavage of ICAM-1 by human neutrophil elastase.
Arthritis, Rheumatoid
Quantitation of human leukocyte elastase, cathepsin G, alpha-2-macroglobulin and alpha-1-proteinase inhibitor in osteoarthrosis and rheumatoid arthritis synovial fluids.
Arthritis, Rheumatoid
Sesquiterpene lactones as inhibitors of human neutrophil elastase.
Arthritis, Rheumatoid
Suppressive effect of a neutrophil elastase inhibitor on the development of collagen-induced arthritis.
Arthritis, Rheumatoid
Suppressive effects of Stephania tetrandra on the neutrophil function in patients with rheumatoid arthritis.
Asbestosis
Special neutrophil elastase inhibitory activity in BAL fluid from patients with silicosis and asbestosis.
Asthma
Absence of airway inflammation in a large proportion of adolescents with asthma.
Asthma
Activity of leukocyte elastase in patients' plasma is a significant indicator of atopic diseases.
Asthma
Biological markers in induced sputum of patients with different phenotypes of chronic airway obstruction.
Asthma
Cytokine concentrations and neutrophil elastase activity in bronchoalveolar lavage and induced sputum from patients with cystic fibrosis, mild asthma and healthy volunteers.
Asthma
Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma.
Asthma
Elevated serum matrix metalloprotease (MMP-2) as a candidate biomarker for stable COPD.
Asthma
Enhancement of ovalbumin-induced pulmonary eosinophilia by intranasal administration of alpha1-proteinase inhibitor type 2 antisense oligonucleotides.
Asthma
Ex vivo Sputum Analysis Reveals Impairment of Protease-dependent Mucus Degradation by Plasma Proteins in Acute Asthma.
Asthma
Hyaluronan blocks porcine pancreatic elastase-induced mucociliary dysfunction in allergic sheep.
Asthma
Increased serum concentration of urinary trypsin inhibitor with asthma exacerbation.
Asthma
Inhibition of human neutrophil elastase by ICI 200,355.
Asthma
Neutrophil elastase inhibitor suppresses oxidative stress in obese asthmatic rats by activating Keap1/Nrf2 signaling pathway.
Asthma
Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease.
Asthma
Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation.
Asthma
Role of neutrophil elastase in hypersecretion in asthma.
Asthma
The role of inducible costimulatory molecular ligand (ICOSL) in children with neutrophilic asthma.
Asthma
[Role of serum neutrophil elastase determination in the diagnosis of acute exacerbation of asthma in preschool children].
Asymptomatic Infections
Induction of immunoresponse by subclinical male genital tract infection?
Atherosclerosis
Age-dependent variations of human PMNL elastase activity as a function of pH, ionic strength and calcium concentration.
Atherosclerosis
Detection of human neutrophil elastase by aptamer affinity capillary electrophoresis coupled with laser-induced fluorescence using specified site fluorescently labeled aptamer.
Atherosclerosis
Elevated serum neutrophil elastase is related to prehypertension and airflow limitation in obese women.
Atherosclerosis
Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis.
Atherosclerosis
Human neutrophil elastase: mediator and therapeutic target in atherosclerosis.
Atherosclerosis
In vitro and in vivo evidence for the role of elastase shedding of CD163 in human atherothrombosis.
Atherosclerosis
Inhibition of human leukocyte elastase by chemically and naturally oversulfated galactosaminoglycans.
Atherosclerosis
Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects.
Atherosclerosis
Neutrophil elastase, von Willebrand factor, soluble thrombomodulin and percutaneous oxygen in peripheral atherosclerosis.
Atherosclerosis
Plasma leukocyte elastase concentration and coronary artery disease.
Autoimmune Diseases
Correlation of PMN elastase and PMN elastase-to-neutrophil ratio with disease activity in patients with myositis.
Autoimmune Diseases
Pyoderma gangrenosum and Wegener granulomatosis-like syndrome induced by cocaine.
Autoimmune Diseases
The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo.
Bacteremia
Influence of the lysosomal elastase inhibitor eglin on the development of interstitial lung edema in E. coli bacteremia in pigs.
Bacteremia
Peritonitis from perforated appendicitis: stress response after laparoscopic or open treatment.
Bacteremia
Peritonitis from Perforated Peptic Ulcer and Immune Response.
Bacteremia
Plasma neutrophil elastase alpha-1-proteinase inhibitor levels in premature neonates with coagulase-negative staphylococcal bacteremia.
Bacteremia
Plasma neutrophil-activating peptide-1/interleukin-8 and neutrophil elastase in a primate bacteremia model.
Bacteremia
Ultrasonic versus standard electric dissection in laparoscopic cholecystectomy in patients with acute calculous cholecystitis, complicated by peritonitis: influence on the postoperative systemic inflammation and immune response. A prospective randomized study.
Bacterial Infections
Alpha-1 Antitrypsin is Markedly Decreased Following Pulmonary F. tularensis Challenge.
Bacterial Infections
Cytochemical determination of intracellular polymorphonuclear leukocyte elastase content in patients with severe bacterial infection and septicaemia correlated with coagulation parameters.
Bacterial Infections
Diagnostic potential of neutrophil elastase inhibitor complex in the routine care of critically ill newborn infants.
Bacterial Infections
Engineering synthetic breath biomarkers for respiratory disease.
Bacterial Infections
Local regulation of neutrophil elastase activity by endogenous ?1-antitrypsin in lipopolysaccharide-primed hematological cells.
Bacterial Infections
Lung Disease at Diagnosis in Infants with Cystic Fibrosis Detected by Newborn Screening.
Bacterial Infections
Neutrophil elastase as a biomarker for bacterial infection in COPD.
Bacterial Infections
Neutrophil Elastase Modulates Cytokine Expression: Contribution to Host defense against Pseudomonas aeruginosa-induced Pneumonia.
Bacterial Infections
Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases.
Bacterial Infections
Structural Basis for the Inhibition Mechanism of Ecotin against Neutrophil Elastase by Targeting the Active Site and Secondary Binding Site.
Bacterial Infections
Thrombin-derived C-terminal fragments aggregate and scavenge bacteria and their proinflammatory products.
Bacterial Infections
Trehalose does not affect the functions of human neutrophils in vitro.
Bacterial Infections
[Clinical and genetic analysis of four patients with congenital neutropenia].
Behcet Syndrome
Assessment of Cytokine Release against Oral Mucosal Cell Line Culture (TR146) Stimulated by Neutrophil Elastase Associated with Behcet's Disease.
beta-Thalassemia
Neutrophil elastase in patients with homozygous beta-thalassemia and pseudoxanthoma elasticum-like syndrome.
Blister
A critical role for neutrophil elastase in experimental bullous pemphigoid.
Blister
Collagen XVII Processing and Blistering Skin Diseases.
Blister
Distinct compartmentalization of immune cells and mediators characterizes bullous pemphigoid disease.
Blister
Evidence of Neutrophil Functional Defect Despite Inflammation in Stable Cirrhosis.
Blister
Innate Immune Cell-Produced IL-17 Sustains Inflammation in Bullous Pemphigoid.
Blister
Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoid.
Blister
The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo.
Bone Marrow Failure Disorders
Paternal Somatic Mosaicism of a Novel Frameshift Mutation in ELANE Causing Severe Congenital Neutropenia.
Bone Marrow Failure Disorders
Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone hypothesis.
Bone Resorption
The expression of macrophage and neutrophil elastases in rat periradicular lesions.
Brain Diseases
Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy.
Brain Diseases
In response to letter to Editor by Nosaka et al. on our paper: Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy. J Neurol Sci 2015;349:190-195.
Brain Diseases
Letter to the Editor regarding the paper by Sun G et al: Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy. J Neuro Sci 2015;349:190-195.
Brain Injuries
S-100b as a screening marker of the severity of minor head trauma (MHT)--a pilot study.
Brain Injuries, Traumatic
Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock.
Brain Ischemia
Involvement of Progranulin and Granulin Expression in Inflammatory Responses after Cerebral Ischemia.
Brain Ischemia
Mesenchymal stem cells transplantation suppresses inflammatory responses in global cerebral ischemia: contribution of TNF-?-induced protein 6.
Brain Ischemia
Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edema.
Brain Ischemia
Neutrophil elastase mediates acute pathogenesis and is a determinant of long-term behavioral recovery after traumatic injury to the immature brain.
Brain Ischemia
Possible involvement of progranulin in the protective effect of elastase inhibitor on cerebral ischemic injuries of neuronal and glial cells.
Brain Ischemia
Thrombolytic properties of leukocytes from peripheral blood in healthy subjects and in patients with acute cerebral ischemia.
Brain Neoplasms
A Pilot Proteomic Analysis of Salivary Biomarkers in Autism Spectrum Disorder.
Brain Neoplasms
Proteomic profile of saliva and plasma from women with impalpable breast lesions.
Breast Neoplasms
Breast cancer cell uptake of the inflammatory mediator neutrophil elastase triggers an anticancer adaptive immune response.
Breast Neoplasms
Elevated expression of polymorphonuclear leukocyte elastase in breast cancer tissue is associated with tamoxifen failure in patients with advanced disease.
Breast Neoplasms
Free-form neutrophil elastase is an independent marker predicting recurrence in primary breast cancer.
Breast Neoplasms
Growth effect of neutrophil elastase on breast cancer: favorable action of sivelestat and application to anti-HER2 therapy.
Breast Neoplasms
Impact of cyclins E, neutrophil elastase and proteinase 3 expression levels on clinical outcome in primary breast cancer patients.
Breast Neoplasms
Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells.
Breast Neoplasms
Neutrophil elastase enhances antigen presentation by upregulating human leukocyte antigen class I expression on tumor cells.
Breast Neoplasms
Neutrophil elastase predicts trastuzumab responsiveness in metastatic breast cancer.
Breast Neoplasms
Prognostic significance of immunoreactive neutrophil elastase in human breast cancer: long-term follow-up results in 313 patients.
Breast Neoplasms
Prognostic significance of three novel biologic factors in a clinical trial of adjuvant therapy for node-negative breast cancer.
Breast Neoplasms
The neutrophil elastase inhibitor elafin triggers rb-mediated growth arrest and caspase-dependent apoptosis in breast cancer.
Breast Neoplasms
The prognostic value of polymorphonuclear leukocyte elastase in patients with primary breast cancer.
Bronchial Diseases
Bronchial inflammation: its relationship to colonizing microbial load and alpha(1)-antitrypsin deficiency.
Bronchial Diseases
New approaches to the management of COPD.
Bronchial Hyperreactivity
Macrolides as biological response modifiers in cystic fibrosis and bronchiectasis.
Bronchiectasis
A point-of-care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation.
Bronchiectasis
Airway inflammation in cystic fibrosis.
Bronchiectasis
AZD9668: pharmacological characterisation of a novel oral inhibitor of neutrophil elastase.
Bronchiectasis
Bronchiectasis in Infants and Preschool Children Diagnosed with Cystic Fibrosis after Newborn Screening.
Bronchiectasis
Cathepsin-G interferes with clearance of Pseudomonas aeruginosa from mouse lungs.
Bronchiectasis
Clinical phenotypes in adult patients with bronchiectasis.
Bronchiectasis
Diagnosis and early life risk factors for bronchiectasis in cystic fibrosis: a review.
Bronchiectasis
Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium.
Bronchiectasis
Evaluation of active neutrophil elastase in sputum of bronchiectasis and cystic fibrosis patients: A comparison among different techniques.
Bronchiectasis
Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy.
Bronchiectasis
Levels of neutrophil elastase and cathepsin B activities, and cystatins in human sputum: relationship to inflammation.
Bronchiectasis
Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis.
Bronchiectasis
Neutrophil Elastase Activity is Associated with Exacerbations and Lung Function Decline in Bronchiectasis.
Bronchiectasis
Neutrophil Elastase and Chronic Lung Disease.
Bronchiectasis
Neutrophil elastase gene polymorphisms: modulators of response to therapy in childhood bronchiectasis?
Bronchiectasis
Neutrophil elastase in bronchiectasis.
Bronchiectasis
Neutrophil elastase inhibitors: recent advances in the development of mechanism-based and nonelectrophilic inhibitors.
Bronchiectasis
Personalised anti-inflammatory therapy for bronchiectasis and cystic fibrosis: selecting patients for controlled trials of neutrophil elastase inhibition.
Bronchiectasis
Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis.
Bronchiectasis
Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis.
Bronchiectasis
Safety and efficacy of the human neutrophil elastase inhibitor BAY 85-8501 for the treatment of non-cystic fibrosis bronchiectasis: A randomized controlled trial.
Bronchiectasis
Sputum Neutrophil Elastase as a Biomarker for Disease Activity in Bronchiectasis.
Bronchiectasis
Sputum Neutrophil Elastase associates with microbiota and P. aeruginosa in bronchiectasis.
Bronchiectasis
Sputum neutrophil elastase in bronchiectasis: a Southern European cohort study.
Bronchiectasis
Sputum sol neutrophil elastase activity in bronchiectasis: differential modulation by syndecan-1.
Bronchiectasis
Sputum sol phase proteins and elastase activity in patients with clinically stable bronchiectasis.
Bronchiectasis
[Clinical and pathophysiological significance of neutrophil elastase in sputum and the effect of erythromycin in chronic respiratory diseases]
Bronchiectasis
[Early lung disease in cystic fibrosis].
Bronchiectasis
[Early lung disease in infants with cystic fibrosis. Diagnostic tools and possible therapeutic pathways].
Bronchiolitis
Human neutrophil elastase in RSV bronchiolitis.
Bronchiolitis
IL-8 and neutrophil elastase levels in the respiratory tract of infants with RSV bronchiolitis.
Bronchiolitis
Neutrophil elastase and obliterative bronchiolitis.
Bronchiolitis
Transforming growth factor-beta1 is a potent inhibitor of secretory leukoprotease inhibitor expression in a bronchial epithelial cell line. Munich Lung Transplant Group.
Bronchitis
Proteolytic inactivation of alpha 1-proteinase inhibitor in infected bronchial secretions from patients with cystic fibrosis.
Bronchitis, Chronic
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Bronchitis, Chronic
Chronic bronchitis: the antiproteinase/proteinase balance and the effect of infection and corticosteroids.
Bronchitis, Chronic
ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure.
Bronchitis, Chronic
Inhibition of human neutrophil elastase by ICI 200,355.
Bronchitis, Chronic
Mucin-producing elements and inflammatory cells.
Bronchitis, Chronic
[Clinical and pathophysiological significance of neutrophil elastase in sputum and the effect of erythromycin in chronic respiratory diseases]
Bronchopulmonary Dysplasia
Effects of the early administration of sivelestat sodium on bronchopulmonary dysplasia in infants: A retrospective cohort study.
Bronchopulmonary Dysplasia
Neutrophil Elastase and Chronic Lung Disease.
Bronchopulmonary Dysplasia
Proteinase-antiproteinase balance in tracheal aspirates from neonates.
Bronchopulmonary Dysplasia
SERPINB1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia.
Bronchopulmonary Dysplasia
The levels of the neutrophil elastase in the amniotic fluid of pregnant women whose infants develop bronchopulmonary dysplasia.
Campylobacter Infections
Induction of neutrophil extracellular traps by Campylobacter jejuni.
Capillary Leak Syndrome
The response of antithrombin III activity after supplementation decreases in proportion to the severity of sepsis and liver dysfunction.
Carcinogenesis
Alpha1-antitrypsin and neutrophil elastase imbalance and lung cancer risk.
Carcinogenesis
Neutrophil elastase in the tumor microenvironment.
Carcinogenesis
Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis.
Carcinogenesis
Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase.
Carcinoma
A large-scale transcriptome analysis identified ELANE and PRTN3 as novel methylation prognostic signatures for clear cell renal cell carcinoma.
Carcinoma
A potentially novel peptidase, resembling but distinct from neutrophil elastase, produced by carcinoma cells.
Carcinoma
A Strong Neutrophil Elastase Proteolytic Fingerprint Marks the Carcinoma Tumor Proteome.
Carcinoma
Assessment of Cytokine Release against Oral Mucosal Cell Line Culture (TR146) Stimulated by Neutrophil Elastase Associated with Behcet's Disease.
Carcinoma
Complete inhibition of spontaneous pulmonary metastasis of human lung carcinoma cell line EBC-1 by a neutrophil elastase inhibitor (ONO-5046.Na).
Carcinoma
Demonstration of skin-derived antileukoproteinase (SKALP) and its target enzyme human leukocyte elastase in squamous cell carcinoma.
Carcinoma
Effect of type of resection on plasma granulocyte elastase levels following surgery for non-small cell lung carcinoma.
Carcinoma
Human colon carcinoma cells synthesize and secrete alpha 1-proteinase inhibitor.
Carcinoma
Latency of cathepsin B secreted by human colon carcinoma cells is not linked to secretion of cystatin C and is relieved by neutrophil elastase.
Carcinoma
Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells.
Carcinoma
Neutrophil elastase induces IL-8 gene transcription and protein release through p38/NF-{kappa}B activation via EGFR transactivation in a lung epithelial cell line.
Carcinoma
Neutrophil elastase inhibitor (ONO-5046.Na) suppresses the proliferation, motility and chemotaxis of a pancreatic carcinoma cell line, Capan-1.
Carcinoma
Polymorphonuclear elastase in human colorectal carcinoma.
Carcinoma
Sivelestat, a specific neutrophil elastase inhibitor, suppresses the growth of gastric carcinoma cells by preventing the release of transforming growth factor-alpha.
Carcinoma
The enigma PAI-2. Gene expression, evolutionary and functional aspects.
Carcinoma, Non-Small-Cell Lung
Adhesion molecule expression in vascular endothelial cells incubated with cancer cell line supernatant are inhibited by neutrophil elastase inhibitor (ONO-5046.Na).
Carcinoma, Non-Small-Cell Lung
Complete inhibition of spontaneous pulmonary metastasis of human lung carcinoma cell line EBC-1 by a neutrophil elastase inhibitor (ONO-5046.Na).
Carcinoma, Non-Small-Cell Lung
Effect of type of resection on plasma granulocyte elastase levels following surgery for non-small cell lung carcinoma.
Carcinoma, Non-Small-Cell Lung
Local increase in polymorphonuclear leukocyte elastase is associated with tumor invasiveness in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Neutrophil Elastase as a Target in Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Neutrophil elastase inhibitor (ONO-5046-Na) inhibits the growth of human lung cancer cell lines transplanted into severe combined immunodeficiency (scid) mice.
Carcinoma, Non-Small-Cell Lung
SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer.
Carcinoma, Non-Small-Cell Lung
Tumor neutrophil elastase is closely associated with the direct extension of non-small cell lung cancer into the aorta.
Carcinoma, Ovarian Epithelial
Neutrophil Granulocytes in Ovarian Cancer - Induction of Epithelial-To-Mesenchymal-Transition and Tumor Cell Migration.
Carcinoma, Renal Cell
A large-scale transcriptome analysis identified ELANE and PRTN3 as novel methylation prognostic signatures for clear cell renal cell carcinoma.
Carcinoma, Squamous Cell
Demonstration of skin-derived antileukoproteinase (SKALP) and its target enzyme human leukocyte elastase in squamous cell carcinoma.
Carcinoma, Squamous Cell
The enigma PAI-2. Gene expression, evolutionary and functional aspects.
Cardiomyopathy, Dilated
Increased expression of promatrix metalloproteinase-9 and neutrophil elastase in canine dilated cardiomyopathy.
Cardiomyopathy, Hypertrophic
Neutrophil extracellular traps in feline cardiogenic arterial thrombi: a pilot study.
Cardiovascular Diseases
Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects.
Cardiovascular Diseases
Neutrophil elastase gene variation and coronary heart disease.
Cardiovascular Diseases
Relative value of inflammatory, hemostatic, and rheological factors for incident myocardial infarction and stroke: the Edinburgh Artery Study.
Cardiovascular Diseases
Serum tissue-degrading proteinases and incident cardiovascular disease events.
Central Nervous System Diseases
[Polymorphonuclear leukocyte elastase in the cerebrospinal fluid in the diagnosis of acute inflammatory central nervous system diseases]
Cerebral Hemorrhage
Increase in jugular levels of polymorphonuclear neutrophil elastase in patients with acute cerebral infarction.
Cerebral Infarction
Increase in jugular levels of polymorphonuclear neutrophil elastase in patients with acute cerebral infarction.
Cerebral Infarction
Neutrophil elastase inhibitor attenuates hippocampal neuronal damage after transient forebrain ischemia in rats.
Chediak-Higashi Syndrome
Neutrophil elastase and cathepsin G protein and messenger RNA expression in bone marrow from a patient with Chediak-Higashi syndrome.
Cholangitis, Sclerosing
Antineutrophil cytoplasmic antibodies: a still-growing class of autoantibodies in inflammatory disorders.
Cholecystolithiasis
Studies on the role of antileukoprotease in respiratory tract diseases.
Chorioamnionitis
Amniotic fluid neutrophil elastase and lactate dehydrogenase: association with histologic chorioamnionitis.
Chorioamnionitis
Impact of subclinical chorioamnionitis on maternal and neonatal outcomes.
Chorioamnionitis
Increased Risk of Intrauterine Transmission of HIV-1 Associated With Granulocyte Elastase in Endocervical Mucus.
Chorioamnionitis
Neutrophil elastase and interleukin-6 in amniotic fluid as indicators of chorioamnionitis and funisitis.
Chorioamnionitis
[The assessment of neutrophil elastase measurements usefulness in pregnant women with premature rupture of fetal membranes and chorioamnionitis suspicion]
Chorioamnionitis
[The study on mechanism of abruptio placentae caused by chorioamnionitis]
Chorioamnionitis
[Usefulness of determination of granulocyte elastase plasma level, c-reactive protein and white blood cell count in prediction in intrauterine infection in pregnant women after PROM]
Chronic Periodontitis
Degradation of noncollagenous components by neutrophil elastase reduces the mechanical strength of rat periodontal ligament.
Chronic Periodontitis
Evaluation of Systemic Levels of Neutrophilic Enzymes in Hypertensive Patients With Chronic Periodontitis.
Chronic Periodontitis
Granulocyte elastase activity and PGE2 levels in gingival crevicular fluid in relation to the presence of subgingival periodontopathogens in subjects with untreated adult periodontitis.
Chronic Periodontitis
Interleukin-8 and granulocyte elastase in gingival crevicular fluid in relation to periodontopathogens in untreated adult periodontitis.
Chronic Periodontitis
Methodological evaluation of gingival crevicular fluid volume and neutrophil elastase levels: sequential sampling, length of sampling time and two different sampling methods.
Chronic Periodontitis
Neutrophil elastase is involved in the initial destruction of human periodontal ligament.
Chronic Periodontitis
Neutrophil elastase levels in the gingival crevicular fluid following hyaluronan gel application in the treatment of chronic periodontitis: A randomized split-mouth study.
Chronic Periodontitis
Oxidative stress, neutrophil elastase and IGFBP7 levels in patients with oropharyngeal cancer and chronic periodontitis.
Chronic Periodontitis
Proinflammatory cytokines production and PMN-elastase release from activated PMN cells in the periodontal disease.
Chronic Periodontitis
Relationship of changes in interleukin-8 levels and granulocyte elastase activity in gingival crevicular fluid to subgingival periodontopathogens following non-surgical periodontal therapy in subjects with chronic periodontitis.
Chronic Periodontitis
Serum and salivary matrix metalloproteinases, neutrophil elastase, myeloperoxidase in patients with chronic or aggressive periodontitis.
Chronic Periodontitis
Smoking and matrix metalloproteinases, neutrophil elastase and myeloperoxidase in chronic periodontitis.
Coinfection
Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections.
Coinfection
[Biochemical wound monitoring. PMN elastase in different healing stages after trauma surgery-orthopedic interventions]
Colic
Development of an enzyme-linked immunosorbent assay for equine neutrophil elastase measurement in blood: preliminary application to colic cases.
Colitis
Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease.
Colitis
Colonic ulceration and increase of neutrophil elastase activity in the acetic acid-induced colitis model in Syrian hamsters.
Colitis
Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters.
Colitis
Faecal neutrophil elastase-antiprotease balance reflects colitis severity.
Colitis
Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis.
Colitis
Investigation of neutrophils in the gut lumen by assay of granulocyte elastase in whole-gut lavage fluid.
Colitis
Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.
Colitis
Neutrophil elastase in colitis: more than a marker of disease activity?
Colitis
NEUTROPHIL ELASTASE INHIBITOR SUPPRESSES IL-17 BASED INFLAMMATION OF MURINE EXPERIMENTAL COLITIS.
Colitis
Pathophysiological studies of trinitrobenzene sulfonic acid-induced colitis in Syrian hamsters (Mesocricetus auratus).
Colitis
Thromboxane A2 up-regulates neutrophil elastase release in Syrian hamsters with trinitrobenzene sulfonic acid-induced colitis.
Colitis
[Application of chosen granulocyte markers in diagnostics of Le?niowski-Crohn's disease and ulcerative colitis--preliminary research]
Colitis, Ulcerative
Antineutrophil cytoplasmic antibodies: a still-growing class of autoantibodies in inflammatory disorders.
Colitis, Ulcerative
Colonic proteinases: increased activity in patients with ulcerative colitis.
Colitis, Ulcerative
Comparison of 4 neutrophil-derived proteins in feces as indicators of disease activity in ulcerative colitis.
Colitis, Ulcerative
Fecal Lactoferrin, Calprotectin, PMN-Elastase, CRP and White Blood Cell Count as an Indicator for Mucosal Healing and Clinical Course of Disease in Patients with Mild to Moderate Ulcerative Colitis: Post HOC Analysis of a Prospective Clinical Trial.
Colitis, Ulcerative
Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies.
Colitis, Ulcerative
PMN-elastase in assessment of patients with inflammatory bowel disease.
Colitis, Ulcerative
Possible involvement of neutrophil elastase in impaired mucosal repair in patients with ulcerative colitis.
Colitis, Ulcerative
Respiratory burst of circulating polymorphonuclear leukocytes and plasma elastase levels in patients with inflammatory bowel disease in remission.
Colitis, Ulcerative
Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis.
Colitis, Ulcerative
The forms and the levels of fecal PMN-elastase in patients with colorectal diseases.
Colitis, Ulcerative
The use of selected neutrophil protein plasma concentrations in the diagnosis of Crohn's disease and ulcerative colitis - a preliminary report.
Colitis, Ulcerative
[Application of chosen granulocyte markers in diagnostics of Le?niowski-Crohn's disease and ulcerative colitis--preliminary research]
Colitis, Ulcerative
[Neutrophil elastase activity in patients with ulcerative colitis]
Colonic Neoplasms
The forms and the levels of fecal PMN-elastase in patients with colorectal diseases.
Colorectal Neoplasms
Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers.
Colorectal Neoplasms
Polymorphonuclear elastase in human colorectal carcinoma.
Common Cold
Secretory leukocyte protease inhibitor in normal, allergic and virus induced nasal secretions.
Communicable Diseases
A possible pathogenic correlation between neutrophil elastase (NE) enzyme and inflammation in the pathogenesis of coronavirus disease 2019 (COVID-19).
Communicable Diseases
Circulating neutrophil elastase in infectious diseases in geriatric patients.
Communicable Diseases
Kallikrein-kinin in infection and cancer.
Connective Tissue Diseases
The role of inflammatory cells and their proteases in extravascular fibrinolysis.
Contracture
Elevated Serum Concentrations of Polymorphonuclear Neutrophilic Leukocyte Elastase in Systemic Sclerosis: Association with Pulmonary Fibrosis.
Contracture
Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: association with pulmonary fibrosis.
Corneal Ulcer
[PMN elastase determination in tear fluid in corneal ulcer]
Coronary Artery Disease
Plasma leukocyte elastase concentration and coronary artery disease.
Coronary Artery Disease
Plasma leukocyte elastase concentration in angiographically diagnosed coronary artery disease.
Coronary Artery Disease
[Activity of leukocyte elastase in coronary disease diagnosed by coronarography]
Coronary Disease
Neutrophil elastase gene variation and coronary heart disease.
Coronary Disease
[Activity of leukocyte elastase in coronary disease diagnosed by coronarography]
COVID-19
A possible pathogenic correlation between neutrophil elastase (NE) enzyme and inflammation in the pathogenesis of coronavirus disease 2019 (COVID-19).
COVID-19
Anti-protease Treatments Targeting Plasmin(ogen) and Neutrophil Elastase May Be Beneficial in Fighting COVID-19.
COVID-19
Elastase and exacerbation of neutrophil innate immunity are involved in multi-visceral manifestations of COVID-19.
COVID-19
Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients.
COVID-19
Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
COVID-19
Neutrophil Extracellular Traps (NETs) in Severe SARS-CoV-2 Lung Disease.
Craniocerebral Trauma
Neutrophil elastase may play a key role in developing symptomatic disseminated intravascular coagulation and multiple organ failure in patients with head injury.
Crohn Disease
Fecal leukocyte proteins in inflammatory bowel disease and irritable bowel syndrome.
Crohn Disease
Frequency of continuing mucosal inflammation in clinically inactive Crohn's disease.
Crohn Disease
Granulocyte elastase and systemic cytokine response after laparoscopic-assisted and open resections in Crohn's disease.
Crohn Disease
Gut luminal neutrophil migration is influenced by the anatomical site of Crohn's disease.
Crohn Disease
PMN-elastase in assessment of patients with inflammatory bowel disease.
Crohn Disease
Respiratory burst of circulating polymorphonuclear leukocytes and plasma elastase levels in patients with inflammatory bowel disease in remission.
Crohn Disease
The forms and the levels of fecal PMN-elastase in patients with colorectal diseases.
Crohn Disease
The use of selected neutrophil protein plasma concentrations in the diagnosis of Crohn's disease and ulcerative colitis - a preliminary report.
Cutis Laxa
Sweet's syndrome leading to acquired cutis laxa (Marshall's syndrome) in an infant with alpha 1-antitrypsin deficiency.
Cystic Fibrosis
2-O, 3-O-Desulfated Heparin Inhibits Neutrophil Elastase-Induced HMGB-1 Secretion and Airway Inflammation.
Cystic Fibrosis
A novel locust (Schistocerca gregaria) serine protease inhibitor with a high affinity for neutrophil elastase.
Cystic Fibrosis
A novel neutrophil elastase inhibitor prevents elastase activation and surface cleavage of the epithelial sodium channel expressed in Xenopus laevis oocytes.
Cystic Fibrosis
A secretory leukocyte protease inhibitor variant with improved activity against lung infection.
Cystic Fibrosis
A small molecule neutrophil elastase inhibitor, KRP-109, inhibits cystic fibrosis mucin degradation.
Cystic Fibrosis
A specialized method of sputum collection and processing for therapeutic interventions in cystic fibrosis.
Cystic Fibrosis
Acute lung injury induced by Pseudomonas aeruginosa elastase in hamsters.
Cystic Fibrosis
Aerosol alpha 1-antitrypsin treatment for cystic fibrosis.
Cystic Fibrosis
Aerosol treatment with MNEI suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection.
Cystic Fibrosis
Aerosolized prolastin suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection.
Cystic Fibrosis
Alginate, the slime exopolysaccharide of Pseudomonas aeruginosa, binds human leukocyte elastase, retards inhibition by alpha 1-proteinase inhibitor, and accelerates inhibition by secretory leukoprotease inhibitor.
Cystic Fibrosis
Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications.
Cystic Fibrosis
Alpha 1-antitrypsin Mitigates the Inhibition of Airway Epithelial Cell Repair by Neutrophil Elastase.
Cystic Fibrosis
Alpha 1-proteinase inhibitor abrogates proteolytic and secretagogue activity of cystic fibrosis sputum.
Cystic Fibrosis
alpha 1-Proteinase inhibitor, elastase activity, and lung disease severity in cystic fibrosis.
Cystic Fibrosis
Alpha-1 Antitrypsin Therapy in Cystic Fibrosis and the Lung Disease Associated with Alpha-1 Antitrypsin Deficiency.
Cystic Fibrosis
Annexin II mediates the neutrophil elastase-stimulated exocytosis of mucin 5ac.
Cystic Fibrosis
Anti-inflammatory activity of neutrophil elastase inhibitors.
Cystic Fibrosis
Anti-inflammatory effects of DX-890, a human neutrophil elastase inhibitor.
Cystic Fibrosis
Attenuation of host defense function of lung phagocytes in young cystic fibrosis patients.
Cystic Fibrosis
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Cystic Fibrosis
Ceramide is Increased in the Lower Airway Epithelium of People with Advanced Cystic Fibrosis Lung Disease.
Cystic Fibrosis
Changes in airway inflammation with pseudomonas eradication in early cystic fibrosis.
Cystic Fibrosis
Chronic bacterial pulmonary infections in advanced cystic fibrosis differently affect the level of sputum neutrophil elastase, IL-8 and IL-6.
Cystic Fibrosis
Cleavage of lymphocyte surface antigens CD2, CD4, and CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis.
Cystic Fibrosis
Colistin stimulates the activity of neutrophil elastase and Pseudomonas aeruginosa elastase.
Cystic Fibrosis
Cytokine concentrations and neutrophil elastase activity in bronchoalveolar lavage and induced sputum from patients with cystic fibrosis, mild asthma and healthy volunteers.
Cystic Fibrosis
Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation.
Cystic Fibrosis
Diagnosis and early life risk factors for bronchiectasis in cystic fibrosis: a review.
Cystic Fibrosis
Different susceptibility of elastase inhibitors to inactivation by proteinases from Staphylococcus aureus and Pseudomonas aeruginosa.
Cystic Fibrosis
Direct assessment of gastrointestinal inflammation and mucosal immunity in children with cystic fibrosis.
Cystic Fibrosis
DX-890 (Dyax).
Cystic Fibrosis
Effect of nebulised recombinant DNase on neutrophil elastase load in cystic fibrosis.
Cystic Fibrosis
Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells.
Cystic Fibrosis
Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor.
Cystic Fibrosis
Effect of recombinant human DNase on alpha1-proteinase inhibitor function: an experimental approach to the combined clinical use of rhDNase and alpha1-PI in CF patients.
Cystic Fibrosis
Effects of cystic fibrosis airway secretions on rat lung: role of neutrophil elastase.
Cystic Fibrosis
Effects of native and oxidation-resistant secretory leukoprotease inhibitor on cystic fibrosis sputum: inhibition of neutrophil elastase activity and of sputum-induced secretion from porcine tracheal submucosal glands.
Cystic Fibrosis
Effects of pentoxifylline on sputum neutrophil elastase and pulmonary function in patients with cystic fibrosis: preliminary observations.
Cystic Fibrosis
Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis.
Cystic Fibrosis
Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis.
Cystic Fibrosis
EPI-hNE4, a proteolysis-resistant inhibitor of human neutrophil elastase and potential anti-inflammatory drug for treating cystic fibrosis.
Cystic Fibrosis
ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure.
Cystic Fibrosis
Evaluation of active neutrophil elastase in sputum of bronchiectasis and cystic fibrosis patients: A comparison among different techniques.
Cystic Fibrosis
Evidence that Pseudomonas aeruginosa elastase does not inactivate the bronchial inhibitor in the presence of leukocyte elastase. Studies with cystic fibrosis sputum and with pure proteins.
Cystic Fibrosis
Glycosaminoglycans as Multifunctional Anti-Elastase and Anti-Inflammatory Drugs in Cystic Fibrosis Lung Disease.
Cystic Fibrosis
Granulocyte elastase-alpha 1-antiproteinase complex in cystic fibrosis: sensitive plasma assay for monitoring pulmonary infections.
Cystic Fibrosis
Granulocyte elastase-mediated proteolysis of alpha 1-antitrypsin in cystic fibrosis bronchopulmonary secretions.
Cystic Fibrosis
Human neutrophil elastase and elastase/alpha 1-antiprotease complex in cystic fibrosis. Comparison with interstitial lung disease and evaluation of the effect of intravenously administered antibiotic therapy.
Cystic Fibrosis
Hyaluronan blocks porcine pancreatic elastase-induced mucociliary dysfunction in allergic sheep.
Cystic Fibrosis
In Vitro Activities against Cystic Fibrosis Pathogens of Synthetic Host Defence Propeptides Processed by Neutrophil Elastase.
Cystic Fibrosis
In vitro inhibition of neutrophil elastase activity by inhaled anti-Pseudomonas antibiotics used in cystic fibrosis patients.
Cystic Fibrosis
Increased expression of senescence markers in cystic fibrosis airways.
Cystic Fibrosis
Induction of interleukin-8 release by lung epithelium with cystic fibrosis epithelial lining fluid is marginally affected by inhibitors of interleukin-1beta.
Cystic Fibrosis
Inhaled porcine pancreatic elastase causes bronchoconstriction via a bradykinin-mediated mechanism.
Cystic Fibrosis
Inhibition of human neutrophil elastase by ICI 200,355.
Cystic Fibrosis
Interleukin-8 up-regulation by neutrophil elastase is mediated by MyD88/IRAK/TRAF-6 in human bronchial epithelium.
Cystic Fibrosis
Lack of neutrophil elastase reduces inflammation, mucus hypersecretion and emphysema, but not mucus obstruction, in mice with CF-like lung disease.
Cystic Fibrosis
Leukocyte elastase inhibition therapy in cystic fibrosis: role of glycosylation on the distribution of alpha-1-proteinase inhibitor in blood versus lung.
Cystic Fibrosis
Levels of free granulocyte elastase in bronchial secretions from patients with cystic fibrosis: effect of antimicrobial treatment against Pseudomonas aeruginosa.
Cystic Fibrosis
Levels of pro- and anti-inflammatory cytokines in cystic fibrosis patients with or without gingivitis.
Cystic Fibrosis
Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis.
Cystic Fibrosis
Modification of some markers of inflammation during treatment for acute respiratory exacerbation in cystic fibrosis.
Cystic Fibrosis
Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor.
Cystic Fibrosis
Molecular principles for heparin oligosaccharide-based inhibition of neutrophil elastase in cystic fibrosis.
Cystic Fibrosis
Mucin overproduction in chronic inflammatory lung disease.
Cystic Fibrosis
Neutrophil collagenase in sputum from patients with cystic fibrosis.
Cystic Fibrosis
Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport.
Cystic Fibrosis
Neutrophil Elastase and Chronic Lung Disease.
Cystic Fibrosis
Neutrophil elastase and elastase-rich cystic fibrosis sputum degranulate human eosinophils in vitro.
Cystic Fibrosis
Neutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung disease.
Cystic Fibrosis
Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch.
Cystic Fibrosis
Neutrophil elastase correlates with increased sphingolipid content in cystic fibrosis sputum.
Cystic Fibrosis
Neutrophil elastase degrades cystic fibrosis transmembrane conductance regulator via calpains and disables channel function in vitro and in vivo.
Cystic Fibrosis
Neutrophil elastase enhances sputum solubilization in cystic fibrosis patients receiving DNase therapy.
Cystic Fibrosis
Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line.
Cystic Fibrosis
Neutrophil elastase inhibition of cell cycle progression in airway epithelial cells in vitro is mediated by p27kip1.
Cystic Fibrosis
Neutrophil elastase inhibitors for cystic fibrosis.
Cystic Fibrosis
Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway.
Cystic Fibrosis
Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4.
Cystic Fibrosis
Neutrophil plasticity enables the development of pathological microenvironments: implications for cystic fibrosis airway disease.
Cystic Fibrosis
Non-peptidic inhibitors of human leukocyte elastase. 1. The design and synthesis of pyridone-containing inhibitors.
Cystic Fibrosis
On the Process of Discovering Leads That Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients.
Cystic Fibrosis
Oncostatin M, but not interleukin-6 or leukemia inhibitory factor, stimulates expression of alpha1-proteinase inhibitor in A549 human alveolar epithelial cells.
Cystic Fibrosis
Personalised anti-inflammatory therapy for bronchiectasis and cystic fibrosis: selecting patients for controlled trials of neutrophil elastase inhibition.
Cystic Fibrosis
Phagocyte extracellular traps in children with neutrophilic airway inflammation.
Cystic Fibrosis
Pharmacokinetics of recombinant secretory leukoprotease inhibitor aerosolized to normals and individuals with cystic fibrosis.
Cystic Fibrosis
Phosphonic pseudopeptides as human neutrophil elastase inhibitors--a combinatorial approach.
Cystic Fibrosis
Polymorphonuclear leukocyte elastase: its effects on the pathogenesis of Pseudomonas aeruginosa infection in cystic fibrosis.
Cystic Fibrosis
Polysulfated Hyaluronan GlycoMira-1111 Inhibits Elastase and Improves Rheology in Cystic Fibrosis Sputum.
Cystic Fibrosis
Prolastin aerosol therapy and sputum taurine in cystic fibrosis.
Cystic Fibrosis
Protection against acute lung injury by intravenous or intratracheal pretreatment with EPI-HNE-4, a new potent neutrophil elastase inhibitor.
Cystic Fibrosis
Proteinase 3, a potent secretagogue in airways, is present in cystic fibrosis sputum.
Cystic Fibrosis
Proteolytic cleavage of ICAM-1 by human neutrophil elastase.
Cystic Fibrosis
Proteolytic inactivation of alpha 1-proteinase inhibitor in infected bronchial secretions from patients with cystic fibrosis.
Cystic Fibrosis
Pulmonary deposition and disappearance of aerosolised secretory leucocyte protease inhibitor.
Cystic Fibrosis
Reduced neutrophil elastase inhibitor elafin and elevated transforming growth factor-?1 are linked to inflammatory response in sputum of cystic fibrosis patients with Pseudomonas aeruginosa.
Cystic Fibrosis
Reduction in neutrophil elastase concentration by recombinant alphal-antitrypsin (recAAT) does not alter bacterial loading in the sputum of cystic fibrosis patients.
Cystic Fibrosis
Safety and efficacy of recombinant alpha(1)-antitrypsin therapy in cystic fibrosis.
Cystic Fibrosis
Sesquiterpene lactones as inhibitors of human neutrophil elastase.
Cystic Fibrosis
Single dose escalation studies with inhaled POL6014, a potent novel selective reversible inhibitor of human neutrophil elastase, in healthy volunteers and subjects with cystic fibrosis.
Cystic Fibrosis
Sputum and Plasma Neutrophil Elastase in Stable Adult Patients With Cystic Fibrosis in Relation to Chronic Pseudomonas Aeruginosa Colonization.
Cystic Fibrosis
Stability of interleukin 8 and neutrophil elastase in bronchoalveolar lavage fluid following long-term storage.
Cystic Fibrosis
Targeting neutrophil elastase in cystic fibrosis.
Cystic Fibrosis
The effects of recombinant human DNase on neutrophil elastase activity and interleukin-8 levels in the sputum of patients with cystic fibrosis.
Cystic Fibrosis
The role of neutrophil elastase in chronic inflammation.
Cystic Fibrosis
Thioredoxin and dihydrolipoic acid inhibit elastase activity in cystic fibrosis sputum.
Cystic Fibrosis
Towards better understanding of the heparin role in NETosis: feasibility of using native mass spectrometry to monitor interactions of neutrophil elastase with heparin oligomers.
Cystic Fibrosis
Transport of bifunctional proteins across respiratory epithelial cells via the polymeric immunoglobulin receptor.
Cystic Fibrosis
Unopposed neutrophil elastase in bronchoalveolar lavage from transplant recipients with cystic fibrosis.
Cystic Fibrosis
Validation of an ELISA for determination of antibodies induced in monkeys against Epi-hNE4, a recombinant protein inhibitor of human neutrophil elastase.
Cystic Fibrosis
Whole body periodic acceleration in normal and reduced mucociliary clearance of conscious sheep.
Cystitis, Interstitial
Increased concentration of neutrophil elastase in urine from patients with interstitial cystitis.
Dementia, Vascular
[Inflammatory markers in Alzheimer's disease and vascular dementia.]
Demyelinating Diseases
Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice.
Dengue
Plasma Neutrophil Elastase, ?1-Antitrypsin, ?2-Macroglobulin and Neutrophil Elastase-?1-Antitrypsin Complex Levels in patients with Dengue Fever.
Dengue
RNA-Seq analysis of peripheral blood mononuclear cells reveals unique transcriptional signatures associated with disease progression in dengue patients.
Dental Plaque
Impact of Smoking on Neutrophil Enzyme Levels in Gingivitis: A Case-Control Study.
Dermatitis
Murine lupus is neutrophil elastase-independent in the MRL.Faslpr model.
Dermatitis Herpetiformis
A comparative study of expression of Fc receptors in relation to the autoantibody-mediated immune response and neutrophil elastase expression in autoimmune blistering dermatoses.
Dermatitis Herpetiformis
Cutaneous expressions of interleukin-6 and neutrophil elastase as well as levels of serum IgA antibodies to gliadin nonapeptides, tissue transglutaminase and epidermal transglutaminase: implications for both autoimmunity and autoinflammation involvement in dermatitis herpetiformis.
Dermatitis, Allergic Contact
Cutaneous expressions of interleukin-6 and neutrophil elastase as well as levels of serum IgA antibodies to gliadin nonapeptides, tissue transglutaminase and epidermal transglutaminase: implications for both autoimmunity and autoinflammation involvement in dermatitis herpetiformis.
Dermatitis, Atopic
Activity of leukocyte elastase in patients' plasma is a significant indicator of atopic diseases.
Dermatitis, Atopic
Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance.
Dermatomyositis
Correlation of PMN elastase and PMN elastase-to-neutrophil ratio with disease activity in patients with myositis.
Diabetes Mellitus
A Novel SERPINB1 Single-Nucleotide Polymorphism Associated With Glycemic Control and ?-Cell Function in Egyptian Type 2 Diabetic Patients.
Diabetes Mellitus
Expression of neutrophil elastase and myeloperoxidase mRNA in patients with newly diagnosed type 2 diabetes mellitus.
Diabetes Mellitus
Neutrophil activation detected by increased neutrophil elastase activity in type 1 (insulin-dependent) diabetes mellitus.
Diabetes Mellitus
Neutrophil count and activation in vascular disease.
Diabetes Mellitus
[Possible participation of angiotensin-converting enzyme and leukocyte elastase in the pathogenesis of insulin-independent diabetes mellitus]
Diabetes Mellitus, Type 1
Increased neutrophil elastase and proteinase 3 and augmented NETosis are closely associated with ?-cell autoimmunity in patients with type 1 diabetes.
Diabetes Mellitus, Type 1
Neutrophil count and activation in vascular disease.
Diabetes Mellitus, Type 1
Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice.
Diabetes Mellitus, Type 1
Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice.
Diabetes Mellitus, Type 2
A Novel SERPINB1 Single-Nucleotide Polymorphism Associated With Glycemic Control and ?-Cell Function in Egyptian Type 2 Diabetic Patients.
Diabetes Mellitus, Type 2
Concentration of leukocyte elastase in plasma and polymorphonuclear neutrophil extracts in type 2 diabetes.
Diabetes Mellitus, Type 2
Expression of neutrophil elastase and myeloperoxidase mRNA in patients with newly diagnosed type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
Diabetes Mellitus, Type 2
The relationship of neutrophil elastase and proteinase 3 with risk factors, and chronic complications in type 2 diabetes: A Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) sub-study.
Diabetes Mellitus, Type 2
[Possible participation of angiotensin-converting enzyme and leukocyte elastase in the pathogenesis of insulin-independent diabetes mellitus]
Diabetes, Gestational
Excessive Neutrophil Activity in Gestational Diabetes Mellitus: Could It Contribute to the Development of Preeclampsia?
Diabetic Angiopathies
Concentration of leukocyte elastase in plasma and polymorphonuclear neutrophil extracts in type 2 diabetes.
Diabetic Ketoacidosis
Changes in serum amylase, lipase and leukocyte elastase during diabetic ketoacidosis and poorly controlled diabetes.
Diabetic Ketoacidosis
Elevated Leukocyte Azurophilic Enzymes in Human Diabetic Ketoacidosis Plasma Degrade Cerebrovascular Endothelial Junctional Proteins.
Diabetic Retinopathy
Evaluation of Circulating Markers of Neutrophil Extracellular Trap (NET) Formation as Risk Factors for Diabetic Retinopathy in a Case-Control Association Study.
Diabetic Retinopathy
Neutrophil elastase contributes to the pathological vascular permeability characteristic of diabetic retinopathy.
Discitis
New inflammation markers for early detection of spondylodiscitis.
Disseminated Intravascular Coagulation
A low TAFI activity and insufficient activation of fibrinolysis by both plasmin and neutrophil elastase promote organ dysfunction in disseminated intravascular coagulation associated with sepsis.
Disseminated Intravascular Coagulation
Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients.
Disseminated Intravascular Coagulation
Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation.
Disseminated Intravascular Coagulation
Disseminated intravascular coagulation at an early phase of trauma is associated with consumption coagulopathy and excessive fibrinolysis both by plasmin and neutrophil elastase.
Disseminated Intravascular Coagulation
Increased neutrophil elastase, persistent intravascular coagulation, and decreased fibrinolytic activity in patients with posttraumatic acute respiratory distress syndrome.
Disseminated Intravascular Coagulation
Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
Disseminated Intravascular Coagulation
Neutrophil elastase may play a key role in developing symptomatic disseminated intravascular coagulation and multiple organ failure in patients with head injury.
Disseminated Intravascular Coagulation
Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both ARDS and DIC patients.
Disseminated Intravascular Coagulation
Soluble thrombomodulin increases in patients with disseminated intravascular coagulation and in those with multiple organ dysfunction syndrome after trauma: role of neutrophil elastase.
Disseminated Intravascular Coagulation
Temporal changes in factors associated with neutrophil elastase and coagulation in intensive care patients with a biphasic waveform and disseminated intravascular coagulation.
Disseminated Intravascular Coagulation
Usefulness of circulating vascular endothelial growth factor and neutrophil elastase as diagnostic markers of disseminated intravascular coagulation in non-cancer patients.
Diverticulitis
Investigation of neutrophils in the gut lumen by assay of granulocyte elastase in whole-gut lavage fluid.
Dry Eye Syndromes
Release of membrane-associated mucins from ocular surface epithelia.
Dyskeratosis Congenita
Current insights into inherited bone marrow failure syndromes.
Dyspnea
[Valproate sodium and zonisamide associated interstitial pneumonitis in an infant]
Ectodermal Dysplasia
Autosomal-dominant primary immunodeficiencies.
Ehlers-Danlos Syndrome
Histomorphometric parameters and susceptibility to neutrophil elastase degradation of skin elastic fibres from healthy individuals and patients with Marfan syndrome, Ehlers-Danlos type IV, and pseudoxanthoma elasticum.
Embolism
How to lower perinatal mortality? Perinatal care in Japan.
Embolism, Air
Specific neutrophil elastase inhibitor does not attenuate acute lung injury induced by air embolism in awake sheep.
Embolism, Amniotic Fluid
How to lower perinatal mortality? Perinatal care in Japan.
Embolism, Fat
From neurogenic pulmonary edema to fat embolism syndrome: a brief review of experimental and clinical investigations of acute lung injury and acute respiratory distress syndrome.
Empyema
Significance of microbiological and biochemical analyses in empyema thoracis.
Empyema
[PMN-elastase as a marker in diagnosis and follow-up of bone and joint infections]
Encephalitis
An alternative elastase-mediated degradation of fibrinogen and fibrin observed in a patient with herpes simplex encephalitis and pneumonia.
Encephalitis, Herpes Simplex
An alternative elastase-mediated degradation of fibrinogen and fibrin observed in a patient with herpes simplex encephalitis and pneumonia.
Encephalomyelitis
A TLR-CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice.
Encephalomyelitis, Autoimmune, Experimental
A TLR-CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice.
Endometriosis
Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals.
Endotoxemia
A Synergy Between Endotoxin and (1?3)-Beta-D-Glucan Enhanced Neutrophil Extracellular Traps in Candida Administered Dextran Sulfate Solution Induced Colitis in FcGRIIB-/- Lupus Mice, an Impact of Intestinal Fungi in Lupus.
Endotoxemia
Neutrophil Elastase Damages the Pulmonary Endothelial Glycocalyx in Lipopolysaccharide-Induced Experimental Endotoxemia.
Endotoxemia
Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model.
Endotoxemia
Neutrophil elastase inhibitors, SC-37698 and SC-39026, reduce endotoxin-induced lung dysfunction in awake sheep.
Endotoxemia
Peritonitis from perforated appendicitis: stress response after laparoscopic or open treatment.
Endotoxemia
Peritonitis from Perforated Peptic Ulcer and Immune Response.
Endotoxemia
Reversible lung neutrophil accumulation can cause lung injury by elastase-mediated mechanisms.
Endotoxemia
The elastase-inhibitor eglin has no effect in an ovine model of endotoxemia.
Endotoxemia
Ultrasonic versus standard electric dissection in laparoscopic cholecystectomy in patients with acute calculous cholecystitis, complicated by peritonitis: influence on the postoperative systemic inflammation and immune response. A prospective randomized study.
Eosinophilia
Functional characteristics of circulating granulocytes in severe congenital neutropenia caused by ELANE mutations.
Epididymitis
Chronic epididymitis: impact on semen parameters and therapeutic options.
Erythema
Skin-infiltrating neutrophils following exposure to solar-simulated radiation could play an important role in photoageing of human skin.
Esophageal Neoplasms
Influence of neutrophil elastase inhibitor on the postoperative course in patients with esophageal cancer after transthoracic esophagectomy.
Esophageal Neoplasms
Optimal Period for the Prophylactic Administration of Neutrophil Elastase Inhibitor for Patients with Esophageal Cancer Undergoing Esophagectomy.
Esophageal Neoplasms
Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer.
Esophageal Neoplasms
Pulmonary hypertension and polymorphonuclear leukocyte elastase after esophageal cancer operations.
Esophageal Neoplasms
The effect of prostaglandin E1 on the increase of serum lactate and plasma granulocyte elastase activity during radical surgery for esophageal cancer.
Esophageal Neoplasms
The effects of the early administration of sivelestat sodium, a selective neutrophil elastase inhibitor, on the postoperative course after radical surgery for esophageal cancer.
Esophageal Neoplasms
[Alteration of serum levels of endotoxin, polymorphonuclear leukocyte elastase, and the molecular markers of the coagulation and fibrinolytic system in the patients with esophageal cancer and lung cancer before and following operation]
Essential Hypertension
Neutrophil count and activation in vascular disease.
Eye Diseases
[PMN elastase determination in tear fluid in corneal ulcer]
Familial Primary Pulmonary Hypertension
Neutrophil Extracellular Traps Promote Angiogenesis: Evidence From Vascular Pathology in Pulmonary Hypertension.
Fanconi Anemia
Current insights into inherited bone marrow failure syndromes.
Fatty Liver
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
Fatty Liver
Mice Deficient in the IL-1? Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD.
Fetal Death
Neuromyelitis optica IgG causes placental inflammation and fetal death.
Fetal Membranes, Premature Rupture
[Importance of plasma PMN granulocyte elastase concentration determination in pregnant patients with premature rupture of fetal membranes]
Fetal Membranes, Premature Rupture
[The assessment of neutrophil elastase measurements usefulness in pregnant women with premature rupture of fetal membranes and chorioamnionitis suspicion]
Fetal Membranes, Premature Rupture
[The value of leukocytes, C-reactive protein and granulocyte elastase in patients with premature rupture of fetal membranes and amniotic infection]
Fetal Membranes, Premature Rupture
[Usefulness of determination of granulocyte elastase plasma level, c-reactive protein and white blood cell count in prediction in intrauterine infection in pregnant women after PROM]
Food Hypersensitivity
Expression of IL-17A concentration and effector functions of peripheral blood neutrophils in food allergy hypersensitivity patients.
Gas Gangrene
Behavior of leukocyte elastase and immunglobulins in septic toxic multiorgan involvement: observations on 50 gas gangrene cases.
Gastritis
Enhanced systemic matrix metalloproteinase response in Helicobacter pylori gastritis.
Genetic Diseases, Inborn
Molecular characterisation of the defective alpha 1-antitrypsin alleles PI Mwurzburg (Pro369Ser), Mheerlen (Pro369Leu), and Q0lisbon (Thr68Ile).
Genetic Diseases, Inborn
Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport.
Genetic Diseases, Inborn
SPARTA clinical trial design: Exploring the efficacy and safety of two dose regimens of alpha1-proteinase inhibitor augmentation therapy in alpha1-antitrypsin deficiency.
Genetic Diseases, Inborn
Strategies for aerosol therapy of alpha 1-antitrypsin deficiency by the aerosol route.
Genetic Diseases, Inborn
Tumor necrosis factor-? driven inflammation in alpha-1 antitrypsin deficiency: a new model of pathogenesis and treatment.
Genetic Diseases, Inborn
[Proteinases and antiproteinases: biomedical correlations]
Giant Cell Arteritis
Temporal arteritis in polymyalgia rheumatica: immune complex deposits and the role of the leukocyte elastase in the pathogenesis.
Gingival Overgrowth
Matrix metalloproteinases (MMP-8 and -9) and neutrophil elastase in gingival crevicular fluid of cyclosporin-treated patients.
Gingivitis
Altered relation between granulocyte elastase and alpha-2-macroglobulin in gingival crevicular fluid from sites with periodontal destruction.
Gingivitis
Concentration of interleukin-1beta and neutrophil elastase activity in gingival crevicular fluid during experimental gingivitis.
Gingivitis
Gingival Inflammation and Salivary or Serum Granulocyte Secreted Enzymes in Patients With Polycystic Ovary Syndrome.
Gingivitis
Granulocyte elastase in gingival crevicular fluid. A possible discriminator between gingivitis and periodontitis.
Gingivitis
Impact of Smoking on Neutrophil Enzyme Levels in Gingivitis: A Case-Control Study.
Gingivitis
Neutrophil elastase and its inhibitors in human gingival crevicular fluid during experimental gingivitis.
Gingivitis
Proinflammatory cytokines production and PMN-elastase release from activated PMN cells in the periodontal disease.
Gingivitis
Regulation of Salivary Peptidoglycan Recognition Protein1in Adolescents.
Gingivitis
Salivary levels of MPO, MMP-8 and TIMP-1 are associated with gingival inflammation response patterns during experimental gingivitis.
Gingivitis
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease.
Gingivitis
[The treatment of periodontal diseases using Diplen-Denta films with chlorhexidine (a clinico-laboratory study)]
Glomerulonephritis
Beneficial effect of neutrophil elastase inhibitor on anti-Thy1.1 nephritis in rats.
Glomerulonephritis
Effect of sivelestat, an inhibitor of neutrophil elastase, on rapidly progressive glomerulonephritis.
Glomerulonephritis
Involvement of neutrophil elastase in crescentic glomerulonephritis.
Glomerulonephritis
Renal expression of matrix metalloproteinases in human ANCA-associated glomerulonephritis.
Glomerulonephritis
Role of neutrophil elastase in the development of renal necrotizing vasculitis.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Severe glucose-6-phosphate dehydrogenase deficiency leads to susceptibility to infection and absent NETosis.
Glucosephosphate Dehydrogenase Deficiency
Severe glucose-6-phosphate dehydrogenase deficiency leads to susceptibility to infection and absent NETosis.
Glycogen Storage Disease
A case of secondary acute myeloid leukemia on a background of glycogen storage disease with chronic neutropenia treated with granulocyte colony stimulating factor.
Gout
P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals.
Graft vs Host Disease
Elevated Neutrophil Elastase in Tears of Ocular Graft-Versus-Host Disease Patients.
Granuloma
[Characterization of structural and cellular components in pulmonary sarcoidosis granuloma]
Granulomatosis with Polyangiitis
Characterization and localization of the genes for mouse proteinase-3 (Prtn3) and neutrophil elastase (Ela2).
Granulomatosis with Polyangiitis
Eosinophil and neutrophil degranulation in ophthalmic lesions of Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Neutrophil granule proteins as targets of leukemia-specific immune responses.
Granulomatosis with Polyangiitis
Structures of human proteinase 3 and neutrophil elastase--so similar yet so different.
Heart Arrest
Alterations of soluble L- and P-selectins during cardiac arrest and CPR.
Heart Arrest
Granulocyte elastase in acute myocardial infarction.
Heart Arrest
Increased neutrophil elastase release in patients with cardiopulmonary arrest: role of elastase inhibitor.
Heart Arrest
Insufficient production of urinary trypsin inhibitor for neutrophil elastase release after cardiac arrest.
Heart Arrest
Out-of-hospital cardiac arrest increases soluble vascular endothelial adhesion molecules and neutrophil elastase associated with endothelial injury.
Heart Defects, Congenital
Neutrophil activation and morbidity in young adults with cyanotic congenital heart disease.
Heart Diseases
Inflammatory response, neutrophil activation, and free radical production after acute myocardial infarction: effect of thrombolytic treatment.
Heart Diseases
Neutrophil activation and morbidity in young adults with cyanotic congenital heart disease.
Heart Diseases
Neutrophil count and activation in vascular disease.
Heart Failure
LTB4 is present in exudative pleural effusions and contributes actively to neutrophil recruitment in the inflamed pleural space.
Heart Rupture
Granulocyte elastase in acute myocardial infarction.
Heart Rupture
Increased pericardial fluid level of matrix metalloproteinase-9 activity in patients with acute myocardial infarction: possible role in the development of cardiac rupture.
Heart Septal Defects, Atrial
Granulocyte elastase release and pulmonary hemodynamics in patients with atrial septal defect.
HELLP Syndrome
Immunohistological study in cases of HELLP syndrome (hemolysis, elevated liver enzymes and low platelets) and acute fatty liver of pregnancy.
Hemangioendothelioma
Hepatic hemangioendothelioma in an infant with severe congenital neutropenia.
Hemorrhagic Fever with Renal Syndrome
Neutrophil Activation in Acute Hemorrhagic Fever With Renal Syndrome Is Mediated by Hantavirus-Infected Microvascular Endothelial Cells.
Hepatitis
Involvement of a serine protease, but not of neutrophil elastase, in tumor necrosis factor-induced lethal hepatitis and induction of platelet-activating factor.
Hepatitis B
Blockade of neutrophil elastase attenuates severe liver injury in hepatitis B transgenic mice.
Hepatitis C
Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors.
Hydrocephalus
Granulocyte elastase activity measurement in the cerebrospinal fluid of patients with purulent meningitis.
Hyperalgesia
A TLR-CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice.
Hyperalgesia
Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis.
Hyperalgesia
Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice.
Hyperemia
Blood viscosity, fibrinogen, and activation of coagulation and leukocytes in peripheral arterial disease and the normal population in the Edinburgh Artery Study.
Hyperemia
Granulocyte elastase release and pulmonary hemodynamics in patients with mitral valvular disease.
Hyperglycemia
Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice.
Hypertension
Elevated serum neutrophil elastase is related to prehypertension and airflow limitation in obese women.
Hypertension
Innate Immune Cells and Hypertension: Neutrophils and Neutrophil Extracellular Traps (NETs).
Hypertension
Monocrotaline-induced cardiopulmonary injury in rats. Modification by the neutrophil elastase inhibitor SC39026.
Hypertension
Neutrophil count and activation in vascular disease.
Hypertension
Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model.
Hypertension
Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency.
Hypertension
The Role of Neutrophils and Neutrophil Elastase in Pulmonary Arterial Hypertension.
Hypertension, Pregnancy-Induced
Immunocytochemical localization of neutrophil elastase in term placenta decidua and myometrium in pregnancy-induced hypertension.
Hypertension, Pregnancy-Induced
Neutrophil activation in pregnancy-induced hypertension.
Hypertension, Pulmonary
Ceramide is Increased in the Lower Airway Epithelium of People with Advanced Cystic Fibrosis Lung Disease.
Hypertension, Pulmonary
Granulocyte elastase release and pulmonary hemodynamics in patients with mitral valvular disease.
Hypertension, Pulmonary
Long-term treatment with oral N-acetylcysteine: affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial.
Hypertension, Pulmonary
Neutrophil Extracellular Traps Promote Angiogenesis: Evidence From Vascular Pathology in Pulmonary Hypertension.
Hypertension, Pulmonary
Pulmonary hypertension and polymorphonuclear leukocyte elastase after esophageal cancer operations.
Hypertension, Pulmonary
Secretory leukoprotease inhibitor attenuates lung injury induced by continuous air embolization into sheep.
Hypertension, Pulmonary
[Changes of neutrophil elastase in COPD and the role of elastase in experimental pulmonary hypertension]
Hyperthyroidism
Contact system activation and high thrombin generation in hyperthyroidism.
Hyperthyroidism
Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy.
Hypotension
Acute blood pressure effects of selected serine proteases in normotensive rats and dogs.
Hypotension
Effect of the elastase inhibitor eglin C in porcine endotoxin shock.
Hypotension
Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats.
Hypotension
[Case of possible transfusion-related acute lung injury during thoracic endovascular aortic repair].
Hypoxia-Ischemia, Brain
[Inflammatory and autoimmune reactions in different forms of nervous system functioning disorders].
Idiopathic Interstitial Pneumonias
ONO-5046 (Ono Pharmaceutical).
Idiopathic Interstitial Pneumonias
[Evaluation of the elastase burden in patients with idiopathic interstitial pneumonia]
Idiopathic Interstitial Pneumonias
[Pathophysiology of acute lung injury]
Idiopathic Interstitial Pneumonias
[The 74th Annual Meeting President Lecture. Pathogenesis and therapy of acute lung injury]
Idiopathic Pulmonary Fibrosis
Analysis of blood neutrophil elastase, glutathione levels and pathological findings in postoperative acute exacerbation of idiopathic pulmonary fibrosis associated with lung cancer: Two case reports.
Idiopathic Pulmonary Fibrosis
Hepatocyte growth factor and neutrophil elastase in idiopathic pulmonary fibrosis.
Idiopathic Pulmonary Fibrosis
[Lung injury in idiopathic pulmonary fibrosis and measurement of immunoreactive neutrophil elastase and alpha 1-protease inhibitor in blood]
Infarction, Middle Cerebral Artery
Neutrophil elastase inhibition reduces cerebral ischemic damage in the middle cerebral artery occlusion.
Infections
?2-integrin LFA1 mediates airway damage following neutrophil transepithelial migration during respiratory syncytial virus infection.
Infections
A Biofilm Matrix-Associated Protease Inhibitor Protects Pseudomonas aeruginosa from Proteolytic Attack.
Infections
A case of secondary acute myeloid leukemia on a background of glycogen storage disease with chronic neutropenia treated with granulocyte colony stimulating factor.
Infections
A kinetic study of the hydrolysis of the N-tosylalanine ester of 3-hydroxy-5-phenylpyrrole and related compounds by human leukocyte elastase.
Infections
A Novel ELANE Mutation Associated with Inflammatory Arthritis, Defective NETosis, and Recurrent Parvoviral Infection.
Infections
A point-of-care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation.
Infections
Aerosolized prolastin suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection.
Infections
Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications.
Infections
alpha 1-Proteinase inhibitor, elastase activity, and lung disease severity in cystic fibrosis.
Infections
Alpha,-antitrypsin and leukocyte elastase in infected and noninfected sputum.
Infections
Alpha-1 Antitrypsin-A Target for MicroRNA-Based Therapeutic Development for Cystic Fibrosis.
Infections
Analysis of BAL fluid in M. avium-intracellulare infection in individuals without predisposing lung disease.
Infections
Antisperm antibodies and microorganisms in genital secretions--a clinically significant relationship?
Infections
Aptamer-capture based assays for human neutrophil elastase.
Infections
Are rhinovirus-induced airway responses in asthma aggravated by chronic allergen exposure?
Infections
Autosomal-dominant primary immunodeficiencies.
Infections
Blood polymorphonuclear leukocyte migration as a predictive marker for infections in severe trauma: comparison with various inflammation parameters.
Infections
Bronchiectasis in Infants and Preschool Children Diagnosed with Cystic Fibrosis after Newborn Screening.
Infections
Capillary plasma neutrophil elastase alpha-1-proteinase inhibitor as infection parameter in neonates.
Infections
Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice.
Infections
Cathepsin G in Experimental Tuberculosis: Relevance for Antibacterial Protection and Potential for Immunotherapy.
Infections
Changes in airway inflammation with pseudomonas eradication in early cystic fibrosis.
Infections
Chlamydia trachomatis antibodies in serum and ejaculate of male patients without acute urethritis.
Infections
Chlamydia trachomatis infection in the genital tract is associated with inflammation and hypospermia in the infertile male of China.
Infections
Chronic bacterial pulmonary infections in advanced cystic fibrosis differently affect the level of sputum neutrophil elastase, IL-8 and IL-6.
Infections
Cleavage of lymphocyte surface antigens CD2, CD4, and CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis.
Infections
Clinical and immunoregulatory effects of roxithromycin therapy for chronic respiratory tract infection.
Infections
Colistin stimulates the activity of neutrophil elastase and Pseudomonas aeruginosa elastase.
Infections
Congenital neutropenia: diagnosis, molecular bases and patient management.
Infections
Corticosteroid-binding globulin cleavage may be pathogen-dependent in bloodstream infection.
Infections
Cyclic neutropenia with a novel gene mutation presenting with a necrotizing soft tissue infection and severe sepsis: case report.
Infections
Diagnosis and early life risk factors for bronchiectasis in cystic fibrosis: a review.
Infections
DNA Methylation patterns of immune response-related genes in inflammatory external root resorption.
Infections
Effects of amoxicillin, gentamicin, and moxifloxacin on the hemolytic activity of Staphylococcus aureus in vitro and in vivo.
Infections
Engineering synthetic breath biomarkers for respiratory disease.
Infections
Evolution of pulmonary inflammation and nutritional status in infants and young children with cystic fibrosis.
Infections
Expression of neutrophil elastase and myeloperoxidase mRNA in patients with newly diagnosed type 2 diabetes mellitus.
Infections
Granulocyte elastase levels do not correlate with anaerobic and aerobic bacterial growth in seminal plasma from infertile men.
Infections
Granulocyte elastase, tumor necrosis factor-alpha and urokinase levels as prognostic markers in severe infection.
Infections
HSCT may lower leukemia risk in ELANE neutropenia: a before-after study from the French Severe Congenital Neutropenia Registry.
Infections
Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia.
Infections
Impact of lung disease on respiratory impedance in young children with cystic fibrosis.
Infections
Impact of Pseudomonas and Staphylococcus infection on inflammation and clinical status in young children with cystic fibrosis.
Infections
In Vitro Activities against Cystic Fibrosis Pathogens of Synthetic Host Defence Propeptides Processed by Neutrophil Elastase.
Infections
Induction of neutrophil extracellular traps by Campylobacter jejuni.
Infections
Inflammation and infection imaging with a 99mTc-neutrophil elastase inhibitor in monkeys.
Infections
Inhibitors of elastase and cathepsin G in Chédiak-Higashi (beige) neutrophils.
Infections
Interleukin 8 and granulocyte elastase alpha 1 proteinase inhibitor complex in the tracheobronchial aspirate of infants with chronic lung disease following inter-uterine infection.
Infections
Interleukin 8 and granulocyte elastase in the tracheobronchial aspirate of infants without respiratory distress syndrome or intrauterine infection and development of chronic lung disease.
Infections
JAGN1 is required for fungal killing in neutrophil extracellular traps: Implications for severe congenital neutropenia.
Infections
Long-term antibiotics in the management of non-CF bronchiectasis--do they improve outcome?
Infections
Lower airway inflammation in infants with cystic fibrosis detected by newborn screening.
Infections
Mannose-binding lectin is present in the infected airway: a possible pulmonary defence mechanism.
Infections
Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis.
Infections
Monocyte-derived extracellular trap (MET) formation induces aggregation and affects motility of human spermatozoa in vitro.
Infections
NETosis delays diabetic wound healing in mice and humans.
Infections
Neutrophil elastase and IL17 expressed in the pig colon during Brachyspira hyodysenteriae infection synergistically with the pathogen induce increased mucus transport speed and production via MAPK3.
Infections
Neutrophil elastase and secretory leukocyte protease inhibitor in prelabor rupture of membranes, parturition and intra-amniotic infection.
Infections
Neutrophil elastase causes tissue damage that decreases host tolerance to lung infection with burkholderia species.
Infections
Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch.
Infections
Neutrophil elastase in the diagnosis of neonatal infection.
Infections
Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model.
Infections
Neutrophil elastase promotes Leishmania donovani infection via interferon-?.
Infections
Neutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cells.
Infections
Neutrophil enzymes in urine for the detection of urethral infection in men.
Infections
Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain.
Infections
Neutrophil-Airway Epithelial Interactions Result in Increased Epithelial Damage and Viral Clearance during Respiratory Syncytial Virus Infection.
Infections
Nonchromogenic hydrolysis of elastase and cathepsin G p-nitroanilide substrates by Pseudomonas aeruginosa elastase.
Infections
Novel roles of protease inhibitors in infection and inflammation.
Infections
Oral immunization with polyvalent bacterial lysate and infection with Streptococcus pneumoniae: influence on interferon-gamma and PMN elastase concentrations in murine bronchoalveolar lavage fluid.
Infections
Oxidative burst and neutrophil elastase contribute to clearance of Aspergillus fumigatus pneumonia in mice.
Infections
Participation and interactions of neutrophil elastase in haemostatic disorders of patients with severe infections.
Infections
Phagocyte extracellular traps in children with neutrophilic airway inflammation.
Infections
PMN elastase in bone and joint infections.
Infections
Polymorphonuclear elastase in neonatal sepsis.
Infections
Polymorphonuclear leukocyte elastase: its effects on the pathogenesis of Pseudomonas aeruginosa infection in cystic fibrosis.
Infections
Preventive effect of ulinastatin on renal scarring in rat model of pyelonephritis induced by direct or ascending infection with Serratia marcescens or Escherichia coli.
Infections
Protease-Specific Biomarkers to Analyse Protease Inhibitors for Emphysema Associated with Alpha 1-Antitrypsin Deficiency. An Overview of Current Approaches.
Infections
Protective role of osteopontin in endodontic infection.
Infections
Reduced Neutrophil Elastase Activity and Neutrophil Extracellular Traps in Pediatric Acute Myeloid Leukemia May Increase the Rate of Infections.
Infections
Relationship between granulocyte elastase levels and perinatal infections.
Infections
Relationship of changes in interleukin-8 levels and granulocyte elastase activity in gingival crevicular fluid to subgingival periodontopathogens following non-surgical periodontal therapy in subjects with chronic periodontitis.
Infections
Relevance of the mouse model as a therapeutic approach for neutrophil proteinase 3-associated human diseases.
Infections
Role of inflammation in respiratory tract infections.
Infections
Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases.
Infections
SARS-CoV-2 mutation 614G creates an elastase cleavage site enhancing its spread in high AAT-deficient regions.
Infections
Selective Bacterial Targeting and Infection-Triggered Release of Antibiotic Colistin Conjugates.
Infections
Serpin A1 and CD91 as host instruments against HIV-1 infection: are extracellular antiviral peptides acting as intracellular messengers?
Infections
Systemic macrophage and neutrophil destruction by secondary necrosis induced by a bacterial exotoxin in a Gram-negative septicaemia.
Infections
Targeting neutrophil elastase in cystic fibrosis.
Infections
The antimicrobial/elastase inhibitor elafin regulates lung dendritic cells and adaptive immunity.
Infections
The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis.
Infections
The effects of sivelestat sodium hydrate on uterine contraction and the concentration of maternal and fetal blood cytokines in a sheep model of intra-amniotic infection induced by lipopolysaccharide.
Infections
The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms.
Infections
The evaluation of markers of prostatic inflammation and function of the prostate gland in patients with chronic prostatitis.
Infections
[Advances in researches on polymorphonuclear neutrophil elastase in semen].
Infections
[Diagnostic value of granulocyte elastase determination in cord blood of newborn infants at risk for maternofetal infection]
Infections
[Increased granulocyte elastase activity in emphysema. Effect of acute infections on the activity of this enzyme]
Infections
[Leukocyte elastase as an indicator for early detection of neonatal infection]
Infections
[Neutrophil elastase level in cord blood and diagnosis of infection in mature and premature neonates]
Infections
[PMN-elastase as a marker in diagnosis and follow-up of bone and joint infections]
Infections
[Polymorphonuclear leukocyte elastase (PMNE) levels in surgical patients with postoperative infections]
Infections
[Pretreatment of acid-induced lung injury with specific neutrophil elastase inhibitor ONO-5046 did not exasperate the subsequent bacterial lung infection by Pseudomonas aeruginosa]
Infections
[Significance of neutrophil elastase in diagnosis of male genital tract infection]
Infections
[The value of leukocytes, C-reactive protein and granulocyte elastase in patients with premature rupture of fetal membranes and amniotic infection]
Infections
[Usefulness of determination of granulocyte elastase plasma level, c-reactive protein and white blood cell count in prediction in intrauterine infection in pregnant women after PROM]
Infertility
Clinical relevance of polymorphonuclear (PMN-) elastase determination in semen and serum during infertility investigation.
Infertility
Semen characteristics and inflammatory mediators in infertile men with different clinical diagnoses.
Infertility
[Content of neutrophil elastase in EPS and seminal plasma: A combined predictor in the diagnosis of type IIIA prostatitis with secondary infertility].
Inflammatory Bowel Diseases
Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease.
Inflammatory Bowel Diseases
Investigation of neutrophils in the gut lumen by assay of granulocyte elastase in whole-gut lavage fluid.
Inflammatory Bowel Diseases
Neutrophil-elastase in chronic inflammatory bowel disease: a marker of disease activity?
Inflammatory Bowel Diseases
Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices.
Inflammatory Bowel Diseases
ONO-6818 Cortech/Ono.
Inflammatory Bowel Diseases
PMN-elastase in assessment of patients with inflammatory bowel disease.
Inflammatory Bowel Diseases
Prospective evaluation of faecal neutrophil-derived proteins in identifying intestinal inflammation: combination of parameters does not improve diagnostic accuracy of calprotectin.
Inflammatory Bowel Diseases
TGF-?1 and granulocyte elastase in the evaluation of activity of inflammatory bowel disease. A pilot study.
Inflammatory Bowel Diseases
The role of inflammatory cells and their proteases in extravascular fibrinolysis.
Inflammatory Bowel Diseases
[Noninvasive Markers in the Assessment of Intestinal Inflammation in Inflammatory Bowel Diseases: Performance of Fecal Lactoferrin, Calprotectin, PMN-Elastase, CRP, and Clinical Indices.]
Influenza, Human
Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy.
Influenza, Human
Human mucus protease inhibitor in airway fluids is a potential defensive compound against infection with influenza A and Sendai viruses.
Influenza, Human
In response to letter to Editor by Nosaka et al. on our paper: Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy. J Neurol Sci 2015;349:190-195.
Influenza, Human
Letter to the Editor regarding the paper by Sun G et al: Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy. J Neuro Sci 2015;349:190-195.
Influenza, Human
No role for neutrophil elastase in influenza-induced cellular recruitment, cytokine production or airway hyperresponsiveness in mice.
Influenza, Human
Porphyromonas gingivalis enzymes enhance infection with human metapneumovirus in vitro.
Influenza, Human
The human mucus protease inhibitor and its mutants are novel defensive compounds against infection with influenza A and Sendai viruses.
Influenza, Human
Two-dimensional gel electrophoresis analysis in simultaneous influenza pneumonia and bacterial infection in mice.
Insulin Resistance
?1-Antitrypsin A treatment attenuates neutrophil elastase accumulation and enhances insulin sensitivity in adipose tissue of mice fed a high-fat diet.
Insulin Resistance
Circulating SerpinB1 levels and clinical features in patients with type 2 diabetes.
Insulin Resistance
Expression of neutrophil elastase and myeloperoxidase mRNA in patients with newly diagnosed type 2 diabetes mellitus.
Insulin Resistance
Imbalance between neutrophil elastase and its inhibitor ?1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure.
Insulin Resistance
Inhibition of NET Release Fails to Reduce Adipose Tissue Inflammation in Mice.
Insulin Resistance
Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects.
Insulin Resistance
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase.
Insulin Resistance
Social Stress Increases Vulnerability to High-Fat Diet-Induced Insulin Resistance by Enhancing Neutrophil Elastase Activity in Adipose Tissue.
Insulin Resistance
Surgical site peptidylarginine deaminase 4 (PAD4), a biomarker of NETosis, correlates with insulin resistance in total joint arthroplasty patients: A preliminary report.
Intellectual Disability
[Immunological reactions in different forms of mental disorders]
Intestinal Obstruction
Direct assessment of gastrointestinal inflammation and mucosal immunity in children with cystic fibrosis.
Invasive Pulmonary Aspergillosis
[Invasive pulmonary aspergillosis in a patient with acute leukemia--the role of neutrophil elastase in in cavity formation]
Irritable Bowel Syndrome
Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices.
Irritable Bowel Syndrome
Prospective evaluation of faecal neutrophil-derived proteins in identifying intestinal inflammation: combination of parameters does not improve diagnostic accuracy of calprotectin.
Ischemic Stroke
Evaluation of granulocyte elastase as a sensitive diagnostic parameter of inflammation in first ischemic stroke.
Joint Diseases
Changes in proteoglycan biosynthesis following leukocyte elastase treatment of bovine articular cartilage in culture.
Joint Diseases
Granulocyte elastase as a new biochemical marker in the diagnosis of chronic joint diseases.
Joint Diseases
[Modification of systemic signs and elastase in neutrophilic granulocytes in inflammatory rheumatic diseases in childhood by immunoglobulin therapy]
Joint Diseases
[New clinico-chemical values in chronic joint diseases. Granulocyte elastase and UDP-D-xylose:proteoglycan core protein-beta-D-xylosyltransferase of chondrocytes]
Keloid
Long-term organ culture of keloid disease tissue.
Keratitis
JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity.
Kidney Failure, Chronic
Leukopenia and rheological anomalies in leukocytes during hemodialysis in patients with chronic renal failure.
Kidney Failure, Chronic
Molecular and functional aspects of alterations in the kallikrein-kinin system activity in human blood plasma at different stages of peritonitis and chronic renal failure.
Kidney Failure, Chronic
Polymorphisms of the ELANE Gene Promoter Region in End-Stage Chronic Kidney Disease Patients.
Leg Ulcer
The use of proteases as prognostic markers for the healing of venous leg ulcers.
Leishmaniasis, Cutaneous
Neutrophil elastase promotes Leishmania donovani infection via interferon-?.
Leukemia
A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia.
Leukemia
Artificially controlled aggregation of proteins and targeting in hematopoietic cells.
Leukemia
Evidence of fibrinogen breakdown by leukocyte enzymes in a patient with acute promyelocytic leukemia.
Leukemia
Genetic heterogeneity in severe congenital neutropenia: how many aberrant pathways can kill a neutrophil?
Leukemia
HSCT may lower leukemia risk in ELANE neutropenia: a before-after study from the French Severe Congenital Neutropenia Registry.
Leukemia
Lymphoid enhancer factor-1 links two hereditary leukemia syndromes through core-binding factor alpha regulation of ELA2.
Leukemia
Neutrophil elastase and granulocyte colony-stimulating factor receptor mutation analyses and leukemia evolution in severe congenital neutropenia patients belonging to the original Kostmann family in northern Sweden.
Leukemia
Neutrophil elastase and its therapeutic effect on leukemia cells.
Leukemia
Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice.
Leukemia
Neutrophil elastase enhances the proliferation and decreases apoptosis of leukemia cells via activation of PI3K/Akt signaling.
Leukemia
Neutrophil elastase produces 52-kD and 30-kD glucocorticoid receptor fragments in the cytosol of human leukemia cells.
Leukemia
Neutrophil granule proteins as targets of leukemia-specific immune responses.
Leukemia
NLS?RAR? modulates acute promyelocytic leukemia NB4 cell proliferation and differentiation via the PI3K/AKT pathway.
Leukemia
PML-controlled responses in severe congenital neutropenia with ELANE-misfolding mutations.
Leukemia
PR1 peptide vaccine induces specific immunity with clinical responses in myeloid malignancies.
Leukemia
The Spectrum of ELANE Mutations and their Implications in Severe Congenital and Cyclic Neutropenia.
Leukemia
Urinary trypsin-inhibitor protects neutrophil chemotaxis in the inflammatory response.
Leukemia
[Role of PMN elastase in fibrinolytic activity in patients with acute promyelocytic leukemia]
Leukemia, Lymphoid
In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Clonal dominance of chronic myelogenous leukemia is associated with diminished sensitivity to the antiproliferative effects of neutrophil elastase.
Leukemia, Myeloid
An anti-PR1/HLA-A2 T cell receptor-like antibody mediates complement dependent cytotoxicity against acute myeloid leukemia progenitor cells.
Leukemia, Myeloid
Characterization of immunologic properties of a second HLA-A2 epitope from a granule protease in CML patients and HLA-A2 transgenic mice.
Leukemia, Myeloid
Cytochemical determination of granulocyte elastase and chymotrypsin in human myeloid cells and its application in acquired deficiency states and diagnosis of myeloid leukemia.
Leukemia, Myeloid
Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant.
Leukemia, Myeloid
Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastase.
Leukemia, Myeloid
In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins.
Leukemia, Myeloid
PR1 peptide vaccine induces specific immunity with clinical responses in myeloid malignancies.
Leukemia, Myeloid
Proteolytic processing of cut homeobox 1 by neutrophil elastase in the MV4;11 myeloid leukemia cell line.
Leukemia, Myeloid
The role of antigen cross-presentation from leukemia blasts on immunity to the leukemia-associated antigen PR1.
Leukemia, Myeloid, Acute
A novel TCR-like CAR with specificity for PR1/HLA-A2 effectively targets myeloid leukemia in vitro when expressed in human adult peripheral blood and cord blood T cells.
Leukemia, Myeloid, Acute
Activity of 8F4, a T-cell receptor-like anti-PR1/HLA-A2 antibody, against primary human AML in vivo.
Leukemia, Myeloid, Acute
High expression of neutrophil elastase predicts improved survival in pediatric acute myeloid leukemia: a report from the Children's Oncology Group.
Leukemia, Myeloid, Acute
Lymphoid enhancer factor-1 links two hereditary leukemia syndromes through core-binding factor alpha regulation of ELA2.
Leukemia, Myeloid, Acute
Proteolytic processing of cut homeobox 1 by neutrophil elastase in the MV4;11 myeloid leukemia cell line.
Leukemia, Myeloid, Acute
Reduced Neutrophil Elastase Activity and Neutrophil Extracellular Traps in Pediatric Acute Myeloid Leukemia May Increase the Rate of Infections.
Leukemia, Myeloid, Acute
The Severe Chronic Neutropenia International Registry: 10-Year Follow-up Report.
Leukemia, Promyelocytic, Acute
A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia.
Leukemia, Promyelocytic, Acute
Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice.
Leukemia, Promyelocytic, Acute
[Role of PMN elastase in fibrinolytic activity in patients with acute promyelocytic leukemia]
leukocyte elastase deficiency
Murine lupus is neutrophil elastase-independent in the MRL.Faslpr model.
leukocyte elastase deficiency
Neutrophil Elastase Deficiency Ameliorates Myocardial Injury Post Myocardial Infarction in Mice.
leukocyte elastase deficiency
Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis.
leukocyte elastase deficiency
White blood cell defects: molecular discoveries and clinical management.
Leukocytosis
Changes in plasma level of human leukocyte elastase during leukocytosis from physical effort.
Leukocytosis
Multi-cellular activation in vivo by endotoxin in humans--limited protection by adenosine infusion.
Leukopenia
Activated neutrophils impair gastric cytoprotection role of neutrophil elastase.
Leukopenia
Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats.
Leukopenia
Adult respiratory distress-like syndrome during hemodialysis: relationship between activation of complement, leukopenia, and release of granulocyte elastase.
Leukopenia
Attenuation of endotoxin-induced pulmonary vascular injury by antithrombin III.
Leukopenia
Biocompatibility of a new high-permeability modified cellulose membrane for haemodialysis.
Leukopenia
Endotoxin-induced pulmonary vascular injury is mainly mediated by activated neutrophils in rats.
Leukopenia
Leukopenia and rheological anomalies in leukocytes during hemodialysis in patients with chronic renal failure.
Leukopenia
Performance and biocompatibility of a new hemodialysis membrane.
Leukopenia
Recombinant human soluble thrombomodulin reduces endotoxin-induced pulmonary vascular injury via protein C activation in rats.
Leukopenia
Role of granulocyte elastase in indomethacin-induced gastric mucosal lesion formation in rats.
Leukopenia
Role of neutrophil elastase in stress-induced gastric mucosal injury in rats.
Liver Cirrhosis, Biliary
Evidence of an increased nitric oxide production in primary biliary cirrhosis.
Liver Diseases
A single-chain variable fragment intrabody prevents intracellular polymerization of Z ?1-antitrypsin while allowing its antiproteinase activity.
Liver Diseases
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
Liver Diseases
Knockdown of Z Mutant Alpha-1 Antitrypsin In Vivo Using Modified DNA Antisense Oligonucleotides.
Liver Diseases
Neutrophil activation in chronic liver disease.
Liver Diseases
Protective effect of neutrophil elastase inhibitor (FR136706) in lethal acute liver failure induced by D-galactosamine and lipopolysaccharide in rats.
Liver Failure
Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury.
Liver Failure, Acute
Protective effect of neutrophil elastase inhibitor (FR136706) in lethal acute liver failure induced by D-galactosamine and lipopolysaccharide in rats.
Lung Diseases
2-O, 3-O-Desulfated Heparin Inhibits Neutrophil Elastase-Induced HMGB-1 Secretion and Airway Inflammation.
Lung Diseases
4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.
Lung Diseases
A novel class of cyclic beta-dicarbonyl leaving groups and their use in the design of benzisothiazolone human leukocyte elastase inhibitors.
Lung Diseases
A specialized method of sputum collection and processing for therapeutic interventions in cystic fibrosis.
Lung Diseases
Aerosolization of recombinant SLPI to augment antineutrophil elastase protection of pulmonary epithelium.
Lung Diseases
Airway inflammation in cystic fibrosis: molecular mechanisms and clinical implications.
Lung Diseases
Alpha 1-antitrypsin Mitigates the Inhibition of Airway Epithelial Cell Repair by Neutrophil Elastase.
Lung Diseases
alpha 1-Proteinase inhibitor, elastase activity, and lung disease severity in cystic fibrosis.
Lung Diseases
Alpha-1 Antitrypsin Deficiency: New Developments in Augmentation and Other Therapies.
Lung Diseases
Alpha-1 Antitrypsin Therapy in Cystic Fibrosis and the Lung Disease Associated with Alpha-1 Antitrypsin Deficiency.
Lung Diseases
Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro.
Lung Diseases
alpha1-Proteinase inhibitor therapy for the prevention of chronic lung disease of prematurity: a randomized, controlled trial.
Lung Diseases
An alpha1-antitrypsin enhancer polymorphism is a genetic modifier of pulmonary outcome in cystic fibrosis.
Lung Diseases
Anti-cytokines as a Strategy in Alpha-1 Antitrypsin Deficiency.
Lung Diseases
Anti-Proteases and Alpha-1 Antitrypsin Augmentation Therapy.
Lung Diseases
Changes in airway inflammation with pseudomonas eradication in early cystic fibrosis.
Lung Diseases
Characterisation of a type II functionally-deficient variant of alpha-1-antitrypsin discovered in the general population.
Lung Diseases
Comparison of urinary desmosine excretion in patients with chronic obstructive pulmonary disease or cystic fibrosis.
Lung Diseases
Complement effectors, C5a and C3a, in cystic fibrosis lung fluid correlate with disease severity.
Lung Diseases
CXC Receptor 1 and 2 and Neutrophil Elastase Inhibitors Alter Radiation-induced Lung Disease in the Mouse.
Lung Diseases
Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases.
Lung Diseases
DX-890 (Dyax).
Lung Diseases
Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency.
Lung Diseases
Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells.
Lung Diseases
Effects of pentoxifylline on sputum neutrophil elastase and pulmonary function in patients with cystic fibrosis: preliminary observations.
Lung Diseases
Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis.
Lung Diseases
Elastase regulates the synthesis of its inhibitor, alpha 1-proteinase inhibitor, and exaggerates the defect in homozygous PiZZ alpha 1 PI deficiency.
Lung Diseases
Elevation of plasma truncated elastase alpha 1-proteinase inhibitor complexes in patients with inflammatory lung diseases.
Lung Diseases
Engineering synthetic breath biomarkers for respiratory disease.
Lung Diseases
Evaluation of airway and circulating inflammatory biomarkers for cystic fibrosis drug development.
Lung Diseases
Exhaled breath condensate MMP-9 levels in children with bronchiectasis.
Lung Diseases
Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY?85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.
Lung Diseases
Gene therapy for alpha-1 antitrypsin deficiency.
Lung Diseases
Human Neutrophil Elastase Activated Fluorescent Probe for Pulmonary Diseases Based on Fluorescence Resonance Energy Transfer Using CdSe/ZnS Quantum Dots.
Lung Diseases
Human neutrophil elastase and elastase/alpha 1-antiprotease complex in cystic fibrosis. Comparison with interstitial lung disease and evaluation of the effect of intravenously administered antibiotic therapy.
Lung Diseases
Human neutrophil elastase releases two pools of mucinlike glycoconjugate from tracheal submucosal gland cells.
Lung Diseases
Identification of novel functional sequence variants in the gene for peptidase inhibitor 3.
Lung Diseases
Impact of lung disease on respiratory impedance in young children with cystic fibrosis.
Lung Diseases
Increased expression of senescence markers in cystic fibrosis airways.
Lung Diseases
Inhaled porcine pancreatic elastase causes bronchoconstriction via a bradykinin-mediated mechanism.
Lung Diseases
Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol.
Lung Diseases
Inhibition of human neutrophil elastase by pentacyclic triterpenes.
Lung Diseases
Inhibition of neutrophil elastase-induced interleukin-8 gene expression by urinary trypsin inhibitor in human bronchial epithelial cells.
Lung Diseases
Interleukin 8 and granulocyte elastase alpha 1 proteinase inhibitor complex in the tracheobronchial aspirate of infants with chronic lung disease following inter-uterine infection.
Lung Diseases
Interleukin 8 and granulocyte elastase alpha 1 proteinase inhibitor complex in the tracheobronchial aspirate of infants with chronic lung disease following respiratory distress syndrome.
Lung Diseases
Interleukin 8 and granulocyte elastase in the tracheobronchial aspirate of infants without respiratory distress syndrome or intrauterine infection and development of chronic lung disease.
Lung Diseases
Knockdown of Z Mutant Alpha-1 Antitrypsin In Vivo Using Modified DNA Antisense Oligonucleotides.
Lung Diseases
Lack of neutrophil elastase reduces inflammation, mucus hypersecretion and emphysema, but not mucus obstruction, in mice with CF-like lung disease.
Lung Diseases
Lung Disease at Diagnosis in Infants with Cystic Fibrosis Detected by Newborn Screening.
Lung Diseases
Measuring and Interpreting Serum AAT Concentration.
Lung Diseases
N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.
Lung Diseases
Naringenin attenuates mucous hypersecretion by modulating reactive oxygen species production and inhibiting NF-?B activity via EGFR-PI3K-Akt/ERK MAPKinase signaling in human airway epithelial cells.
Lung Diseases
Neutrophil Elastase and Chronic Lung Disease.
Lung Diseases
Neutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung disease.
Lung Diseases
Neutrophil elastase in human atherosclerotic plaques: production by macrophages.
Lung Diseases
Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).
Lung Diseases
Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex.
Lung Diseases
Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts.
Lung Diseases
Neutrophil elastase: mediator of extracellular matrix destruction and accumulation.
Lung Diseases
Neutrophil plasticity enables the development of pathological microenvironments: implications for cystic fibrosis airway disease.
Lung Diseases
Non-Antibiotic Macrolides Prevent Human Neutrophil Elastase-Induced Mucus Stasis and Airway Surface Liquid Volume Depletion.
Lung Diseases
Novel neutrophil elastase inhibitors as a treatment for neutrophil-predominant inflammatory lung diseases.
Lung Diseases
NullCanada: A novel ?1-antitrypsin allele with in cis variants Glu366Lys and Ile100Asn.
Lung Diseases
Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase.
Lung Diseases
Optimization of O3-acyl kojic acid derivatives as potent and selective human neutrophil elastase inhibitors.
Lung Diseases
Patterns of neutrophil serine protease-dependent cleavage of surfactant protein D in inflammatory lung disease.
Lung Diseases
Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders.
Lung Diseases
Polysulfated Hyaluronan GlycoMira-1111 Inhibits Elastase and Improves Rheology in Cystic Fibrosis Sputum.
Lung Diseases
Protease-antiprotease imbalance in the lungs of children with cystic fibrosis.
Lung Diseases
Proteolytic activity in patients with hypercatabolic renal failure.
Lung Diseases
Pulmonary deposition and disappearance of aerosolised secretory leucocyte protease inhibitor.
Lung Diseases
Secretory leukocyte protease inhibitor in cystic fibrosis.
Lung Diseases
Secretory leukocyte proteinase inhibitor and elafin are resistant to degradation by MMP-8.
Lung Diseases
Separation of closely related peptide substrates of human proteinases by micellar electrokinetic chromatography with anionic and nonionic surfactants.
Lung Diseases
SPLUNC1 has Antimicrobial and Antibiofilm Activity against Burkholderia cepacia Complex.
Lung Diseases
Synthesis in yeast of a functional oxidation-resistant mutant of human alpha-antitrypsin.
Lung Diseases
Targeted delivery of antiprotease to the epithelial surface of human tracheal xenografts.
Lung Diseases
The clinical significance of oropharyngeal cultures in young children with cystic fibrosis.
Lung Diseases
The Role of Neutrophil Elastase Inhibitors in Lung Diseases.
Lung Diseases
Therapeutic potential of neutrophil-elastase inhibition in pulmonary disease.
Lung Diseases
Transport of bifunctional proteins across respiratory epithelial cells via the polymeric immunoglobulin receptor.
Lung Diseases
Use of modulators of airways inflammation in patients with CF.
Lung Diseases
Whole body periodic acceleration in normal and reduced mucociliary clearance of conscious sheep.
Lung Diseases
[The role of neutrophil elastase in pathophysiology of obturative pulmonary diseases]
Lung Diseases, Interstitial
Fibrinopeptide A reactive peptides and procoagulant activity in bronchoalveolar lavage: relationship to rheumatoid interstitial lung disease.
Lung Diseases, Interstitial
Human neutrophil elastase and elastase/alpha 1-antiprotease complex in cystic fibrosis. Comparison with interstitial lung disease and evaluation of the effect of intravenously administered antibiotic therapy.
Lung Diseases, Interstitial
Lung lavage neutrophils, neutrophil elastase and albumin in the prognosis of pulmonary sarcoidosis.
Lung Diseases, Interstitial
Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders.
Lung Diseases, Interstitial
Serum neutrophil elastase levels predict initial clinical condition but do not correlate with the progression of interstitial lung disease.
Lung Diseases, Interstitial
[Prognostic significance of neutrophil elastase inhibitor in patients with acute lung injury and interstitial pneumonia]
Lung Diseases, Interstitial
[Strategy of therapy for interstitial lung disease due to chemotherapeutic drugs or radiation]
Lung Diseases, Obstructive
Biosynthesis of alpha1-proteinase inhibitor by human lung-derived epithelial cells.
Lung Diseases, Obstructive
Elevated serum neutrophil elastase is related to prehypertension and airflow limitation in obese women.
Lung Injury
A neutrophil elastase inhibitor improves lung function during ex vivo lung perfusion.
Lung Injury
A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats.
Lung Injury
A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1.
Lung Injury
Administration of truncated secretory leukoprotease inhibitor ameliorates bleomycin-induced pulmonary fibrosis in hamsters.
Lung Injury
Alleviation of lung injury by glycyrrhizic acid in benzo(a)pyrene exposed rats: Probable role of soluble epoxide hydrolase and thioredoxin reductase.
Lung Injury
Beneficial effect of an inhibitor of leukocyte elastase (EPI-hNE-4) in presence of repeated lung injuries.
Lung Injury
Combined effects of sivelestat and resveratrol on severe acute pancreatitis-associated lung injury in rats.
Lung Injury
Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury.
Lung Injury
Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs.
Lung Injury
Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats.
Lung Injury
Effects of granulocyte colony-stimulating factor (G-CSF) and neutrophil elastase inhibitor (ONO-5046) on acid-induced lung injury in rats.
Lung Injury
Effects of lecithinized superoxide dismutase and a neutrophil elastase inhibitor (ONO-5046) on hyperoxic lung injury in rat.
Lung Injury
Effects of neutrophil elastase inhibitor (ONO-5046) on lung injury after intestinal ischemia-reperfusion.
Lung Injury
Effects of ONO-5046, a specific neutrophil elastase inhibitor, on endotoxin-induced lung injury in sheep.
Lung Injury
Effects of pentoxifylline on sputum neutrophil elastase and pulmonary function in patients with cystic fibrosis: preliminary observations.
Lung Injury
Effects of sivelestat sodium hydrate on the reduction of radiation pneumonitis.
Lung Injury
Evidence of increased matrix metalloproteinase-9 concentration in patients following cardiopulmonary bypass.
Lung Injury
Human neutrophil elastase within human alveolar macrophages. Implications for lung injury.
Lung Injury
In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia.
Lung Injury
Inhibition of human neutrophil elastase by polyguanylic acid and other synthetic RNA homopolymers.
Lung Injury
Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster.
Lung Injury
Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters.
Lung Injury
Inhibition of the activity of human leukocyte elastase by lipids particularly oleic acid and retinoic acid.
Lung Injury
Intratracheally-instilled antileukoprotease and alpha 1-proteinase inhibitor: effect on human neutrophil elastase-induced experimental emphysema and pulmonary localization.
Lung Injury
Lung injury in Fischer but not Sprague-Dawley rats after short-term hyperoxia.
Lung Injury
Neutrophil elastase and oxygen radicals: synergism in lung injury after hindlimb ischemia.
Lung Injury
Neutrophil elastase augments acute edematous injury in isolated rat lungs perfused with neutrophil cytoplasts.
Lung Injury
Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis.
Lung Injury
Neutrophil elastase inhibitor reduces ventilation-induced lung injury via nuclear factor-?B and NF-?B repressing factor in mice.
Lung Injury
Neutrophil elastase inhibitor, ONO-5046, modulates acid-induced lung and systemic injury in rabbits.
Lung Injury
Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia.
Lung Injury
Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats.
Lung Injury
Neutrophil elastase: alpha-1-proteinase inhibitor complex in serum and bronchoalveolar lavage fluid in patients with pulmonary fibrosis.
Lung Injury
New properties of the soybean trypsin inhibitor: Inhibition of human neutrophil elastase and its effect on acute pulmonary injury.
Lung Injury
Noninvasive in vivo quantification of neutrophil elastase activity in acute experimental mouse lung injury.
Lung Injury
Novel Sulfonamide Analogs of Sivelestat as Potent Human Neutrophil Elastase Inhibitors.
Lung Injury
Plasma elastase levels and the development of the adult respiratory distress syndrome.
Lung Injury
Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats.
Lung Injury
Preventive effect of erythromycin on experimental bleomycin-induced acute lung injury in rats.
Lung Injury
Proteases and lung injury.
Lung Injury
Protective effects of ONO-5046*Na, a specific neutrophil elastase inhibitor, on postperfusion lung injury.
Lung Injury
Pulsatile extracorporeal circulation--let it be?
Lung Injury
Reversible lung neutrophil accumulation can cause lung injury by elastase-mediated mechanisms.
Lung Injury
Role of neutrophil elastase in lung injury induced by burn-blast combined injury in rats.
Lung Injury
Role of neutrophils in xanthine/xanthine oxidase-induced oxidant injury in isolated rabbit lungs.
Lung Injury
Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit.
Lung Injury
Sivelestat Attenuates Lung Injury in Surgery for Congenital Heart Disease With Pulmonary Hypertension.
Lung Injury
Sivelestat reduces myocardial ischemia and reperfusion injury in rat hearts even when administered after onset of myocardial ischemia.
Lung Injury
Sivelestat sodium hydrate reduces radiation-induced lung injury in mice by inhibiting neutrophil elastase.
Lung Injury
Streptococcus pneumoniae disrupts pulmonary immune defence via elastase release following pneumolysin-dependent neutrophil lysis.
Lung Injury
Sulfated polysaccharides prevent human leukocyte elastase-induced acute lung injury and emphysema in hamsters.
Lung Injury
Suppression of superantigen-induced lung injury and vasculitis by preadministration of human urinary trypsin inhibitor.
Lung Injury
Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats.
Lung Injury
The effects of a neutrophil elastase inhibitor (ONO-5046.Na) and neutrophil depletion using a granulotrap (G-1) column on lung reperfusion injury in dogs.
Lung Injury
The high-mobility group protein B1-Toll-like receptor 4 pathway contributes to the acute lung injury induced by bilateral nephrectomy.
Lung Injury
The use of neutrophil elastase inhibitor in the treatment of acute lung injury after pneumonectomy.
Lung Injury
Triolein increases microvascular permeability in isolated perfused rabbit lungs: role of neutrophils.
Lung Injury
Xanthine oxidase mediates elastase-induced injury to isolated lungs and endothelium.
Lung Injury
[Diagnosis of acute respiratory distress syndrome: analysis of bronchoalveolar lavage fluid]
Lung Injury
[Effect of sivelestat sodium on acute lung injury after acute aortic dissection]
Lung Injury
[Lung injury in idiopathic pulmonary fibrosis and measurement of immunoreactive neutrophil elastase and alpha 1-protease inhibitor in blood]
Lung Injury
[Pretreatment of acid-induced lung injury with specific neutrophil elastase inhibitor ONO-5046 did not exasperate the subsequent bacterial lung infection by Pseudomonas aeruginosa]
Lung Injury
[Protective effects of ulinastatin on the lung injury during cardiopulmonary bypass]
Lung Injury
[Responses of TNF alpha, IL-8, and leukocyte adhesion molecule CD18 to cardiopulmonary bypass]
Lung Neoplasms
Activity-based Near-Infrared Fluorogenic Probe Enables In Vitro and In Vivo Profiling of Neutrophil Elastase.
Lung Neoplasms
Adhesion molecule expression in vascular endothelial cells incubated with cancer cell line supernatant are inhibited by neutrophil elastase inhibitor (ONO-5046.Na).
Lung Neoplasms
Alpha-1-antitrypsin Phenotypes and Neutrophil Elastase Gene Promoter Polymorphisms in Lung Cancer.
Lung Neoplasms
Alpha1-antitrypsin and neutrophil elastase imbalance and lung cancer risk.
Lung Neoplasms
Analysis of blood neutrophil elastase, glutathione levels and pathological findings in postoperative acute exacerbation of idiopathic pulmonary fibrosis associated with lung cancer: Two case reports.
Lung Neoplasms
Complete inhibition of spontaneous pulmonary metastasis of human lung carcinoma cell line EBC-1 by a neutrophil elastase inhibitor (ONO-5046.Na).
Lung Neoplasms
Correlation between increased granulocyte elastase release and activation of blood coagulation in patients with lung cancer.
Lung Neoplasms
Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of ?1-antitrypsin in lung cancer.
Lung Neoplasms
Human Neutrophil Elastase Activated Fluorescent Probe for Pulmonary Diseases Based on Fluorescence Resonance Energy Transfer Using CdSe/ZnS Quantum Dots.
Lung Neoplasms
Insulin Receptor Substrate Regulation of Phosphoinositol-3 Kinase.
Lung Neoplasms
Local increase in polymorphonuclear leukocyte elastase is associated with tumor invasiveness in non-small cell lung cancer.
Lung Neoplasms
Local increase of antiprotease and neutrophil elastase-alpha 1-proteinase inhibitor complexes in lung cancer.
Lung Neoplasms
Near-infrared fluorescent probe with large stokes shift for detecting Human Neutrophil elastase in living cells.
Lung Neoplasms
Neutrophil Elastase as a Target in Lung Cancer.
Lung Neoplasms
Neutrophil elastase inhibitor (ONO-5046-Na) inhibits the growth of human lung cancer cell lines transplanted into severe combined immunodeficiency (scid) mice.
Lung Neoplasms
Neutrophil serine proteases: mediators of innate immune responses.
Lung Neoplasms
Opposite angiogenic outcome of curcumin against ischemia and Lewis lung cancer models: in silico, in vitro and in vivo studies.
Lung Neoplasms
Polymorphisms in the promoter region of neutrophil elastase gene and lung cancer risk.
Lung Neoplasms
Polymorphisms in the promoter region of the neutrophil elastase gene are associated with lung cancer development.
Lung Neoplasms
Serine Proteases Enhance Immunogenic Antigen Presentation on Lung Cancer Cells.
Lung Neoplasms
SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer.
Lung Neoplasms
Study on Perioperative Administration of a Neutrophil Elastase Inhibitor for Interstitial Pneumonias.
Lung Neoplasms
The role of inflammatory cells and their proteases in extravascular fibrinolysis.
Lung Neoplasms
Tumor neutrophil elastase is closely associated with the direct extension of non-small cell lung cancer into the aorta.
Lung Neoplasms
[Alteration of serum levels of endotoxin, polymorphonuclear leukocyte elastase, and the molecular markers of the coagulation and fibrinolytic system in the patients with esophageal cancer and lung cancer before and following operation]
Lung Neoplasms
[Strategy of therapy for interstitial lung disease due to chemotherapeutic drugs or radiation]
Lung Neoplasms
[Study on extravascular lung water and polymorphonuclear leukocyte elastase during acute phase following radical treatment of lung cancer: effect of ulinastatin on respiratory functions]
Lupus Erythematosus, Systemic
Changes of neutrophil elastase and alpha 1-antitrypsin in systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Plasma lactoferrin and neutrophil elastase in rheumatoid arthritis and systemic lupus erythematosus.
Lymphoma
Can mutations in ELA2, neutrophil elastase expression or differential cell toxicity explain sulphasalazine-induced agranulocytosis?
Lymphoma
Hemostatic abnormalities and leukocyte activation caused by infection in patients with malignant lymphoma during chemotherapy.
Lymphoma
Leukocyte elastase in murine and human non-Hodgkin lymphomas.
Malaria
Activation of the coagulation cascade in severe falciparum malaria through the intrinsic pathway.
Malaria
CXCR4 and MIF are required for neutrophil extracellular trap release triggered by Plasmodium-infected erythrocytes.
Malaria
Polymorphonuclear leucocyte elastase in Plasmodium falciparum malaria.
Malaria, Cerebral
Removal of plasma polymorphonuclear leukocyte elastase and TNFalpha in a child with cerebral malaria by means of PD: a case report.
Malnutrition
[Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity]
Marfan Syndrome
Histomorphometric parameters and susceptibility to neutrophil elastase degradation of skin elastic fibres from healthy individuals and patients with Marfan syndrome, Ehlers-Danlos type IV, and pseudoxanthoma elasticum.
Maxillary Sinusitis
Antileukoprotease in patients with maxillary sinusitis.
Melanoma
Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant.
Melanoma
Localization of MGSA/GRO protein in cutaneous lesions.
Melanoma
Loss of E-cadherin as Part of a Migratory Phenotype in Melanoma Is Associated With Ulceration.
Meningitis
Granulocyte elastase activity measurement in the cerebrospinal fluid of patients with purulent meningitis.
Meningitis
[The value of granulocyte elastase in the early diagnosis of infantile meningitis]
Meningitis, Aseptic
Granulocyte elastase activity measurement in the cerebrospinal fluid of patients with purulent meningitis.
Meningococcal Infections
Elastase and granzymes during meningococcal disease in children: correlation to disease severity.
Mucocutaneous Lymph Node Syndrome
Circulating matrix metalloproteinases and their inhibitors in patients with Kawasaki disease.
Mucocutaneous Lymph Node Syndrome
Immunoreactive polymorphonuclear leukocyte elastase in complex with alpha 1-antitrypsin in Kawasaki disease.
Mucocutaneous Lymph Node Syndrome
The role of bacterial lipopolysaccharide-bound neutrophils in the pathogenesis of Kawasaki disease.
Mucocutaneous Lymph Node Syndrome
Ulinastatin, a urinary trypsin inhibitor, for the initial treatment of patients with Kawasaki disease: a retrospective study.
Mucositis
Neutrophil elastase inhibitor (MPH-966) improves intestinal mucosal damage and gut microbiota in a mouse model of 5-fluorouracil-induced intestinal mucositis.
Multiple Sclerosis
Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain.
Mycobacterium avium-intracellulare Infection
Analysis of BAL fluid in M. avium-intracellulare infection in individuals without predisposing lung disease.
Myocardial Infarction
Granulocyte elastase in acute myocardial infarction.
Myocardial Infarction
Increased neutrophil elastase release in unstable angina pectoris and acute myocardial infarction.
Myocardial Infarction
Inflammatory response, neutrophil activation, and free radical production after acute myocardial infarction: effect of thrombolytic treatment.
Myocardial Infarction
Neutrophil Elastase Deficiency Ameliorates Myocardial Injury Post Myocardial Infarction in Mice.
Myocardial Infarction
Role of PMN elastase on ischemic myocardial injury in evolving myocardial infarction: correlation with clinical parameters and intervention by protease inhibitor ulinastatin.
Myocardial Infarction
[Clinical implication of plasma PMN elastase (alpha 1-proteinase inhibitor-elastase complex) in patients with early stage of acute myocardial infarction]
Myocardial Infarction
[Clinical value of PMN elastase activity before reperfusion therapy in acute myocardial infarction: comparison with clinical characteristics, reperfusion events and myocardial damage]
Myocardial Stunning
Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine.
Myositis
Correlation of PMN elastase and PMN elastase-to-neutrophil ratio with disease activity in patients with myositis.
Nasal Polyps
Allergic fungal sinusitis: an immunohistologic analysis.
Nasal Polyps
[Expression of eosinophil major basic protein and neutrophil elastase in nasal polyp tissue and secretion]
Neonatal Sepsis
Distribution of human neutrophil elastase in diffuse alveolar damage and pneumonia in a case of neonatal sepsis.
Neonatal Sepsis
Identification of Key mRNAs and lncRNAs in Neonatal Sepsis by Gene Expression Profiling.
Neoplasm Metastasis
A large-scale transcriptome analysis identified ELANE and PRTN3 as novel methylation prognostic signatures for clear cell renal cell carcinoma.
Neoplasm Metastasis
Complete inhibition of spontaneous pulmonary metastasis of human lung carcinoma cell line EBC-1 by a neutrophil elastase inhibitor (ONO-5046.Na).
Neoplasm Metastasis
Elastin in the Tumor Microenvironment.
Neoplasm Metastasis
Electrochemical sensing of human neutrophil elastase and polymorphonuclear neutrophil activity.
Neoplasm Metastasis
Elevated expression of polymorphonuclear leukocyte elastase in breast cancer tissue is associated with tamoxifen failure in patients with advanced disease.
Neoplasm Metastasis
Inhibition of PMN-elastase activity by semisynthetic glucan sulfates.
Neoplasm Metastasis
Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers.
Neoplasm Metastasis
Neutrophil elastase in the tumor microenvironment.
Neoplasm Metastasis
Neutrophil elastase inhibitor reduces hepatic metastases induced by ischaemia-reperfusion in rats.
Neoplasm Metastasis
Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis.
Neoplasm Metastasis
Prognostic significance of three novel biologic factors in a clinical trial of adjuvant therapy for node-negative breast cancer.
Neoplasm Metastasis
Role of imbalance between neutrophil elastase and alpha 1-antitrypsin in cancer development and progression.
Neoplasm Metastasis
The prognostic value of polymorphonuclear leukocyte elastase in patients with primary breast cancer.
Neoplasm Metastasis
The role of neutrophil death in chronic inflammation and cancer.
Neoplasm Metastasis
Tumor neutrophil elastase is closely associated with the direct extension of non-small cell lung cancer into the aorta.
Neoplasms
(-)Epigallocatechin-3-gallate inhibits leukocyte elastase: potential of the phyto-factor in hindering inflammation, emphysema, and invasion.
Neoplasms
3,4,5-Trihydroxycinnamic acid attenuates lipopolysaccharide (LPS)-induced acute lung injury via downregulating inflammatory molecules and upregulating HO-1/AMPK activation.
Neoplasms
5'-adenosine monophosphate-induced hypothermia attenuates brain ischemia/reperfusion injury in a rat model by inhibiting the inflammatory response.
Neoplasms
A Cluster Analysis of Bronchiectasis Patients Based on the Airway Immune Profile.
Neoplasms
A novel minimal invasive mouse model of extracorporeal circulation.
Neoplasms
A pulmonary metastatic model of human non-small cell lung carcinoma cells that produce a neutrophil elastase-like molecule in severe combined immunodeficiency mice.
Neoplasms
A repertoire of cytokines in human seminal plasma.
Neoplasms
A Strong Neutrophil Elastase Proteolytic Fingerprint Marks the Carcinoma Tumor Proteome.
Neoplasms
Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis.
Neoplasms
Adhesion molecule expression in vascular endothelial cells incubated with cancer cell line supernatant are inhibited by neutrophil elastase inhibitor (ONO-5046.Na).
Neoplasms
Adsorption of complement, cytokines, and proteins by different dialysis membrane materials: evaluation by confocal laser scanning fluorescence microscopy.
Neoplasms
Airway inflammation and etiology of acute exacerbations of chronic bronchitis.
Neoplasms
Anti-inflammatory effects of troxerutin are mediated through elastase inhibition.
Neoplasms
Antithrombin can modulate coagulation, cytokine production, and expression of adhesion molecules in abdominal aortic aneurysm repair surgery.
Neoplasms
Association between injury pattern of patients with multiple injuries and circulating levels of soluble tumor necrosis factor receptors, interleukin-6 and interleukin-10, and polymorphonuclear neutrophil elastase.
Neoplasms
Balanced Ultrafiltration: Inflammatory Mediator Removal Capacity.
Neoplasms
Biomimetic Liposome with Surface-Bound Elastase for Enhanced Tumor Penetration and Chemo-Immumotherapy.
Neoplasms
Broad cross-presentation of the hematopoietically derived PR1 antigen on solid tumors leads to susceptibility to PR1-targeted immunotherapy.
Neoplasms
Budesonide instillation immediately after reperfusion ameliorates ischemia/reperfusion-induced injury in the transplanted lung of rat.
Neoplasms
Cancer-promoting mechanisms of tumor-associated neutrophils.
Neoplasms
Cardiopulmonary bypass with modified fluid gelatin and heparin-coated circuits.
Neoplasms
Cathepsin-G and leukocyte elastase inactivate human tumor necrosis factor and lymphotoxin.
Neoplasms
Cell biologic factors and cancer spread.
Neoplasms
Circulating interleukin 6 as a useful marker for predicting postoperative complications.
Neoplasms
Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer.
Neoplasms
Clathrin pit-mediated endocytosis of neutrophil elastase and cathepsin G by cancer cells.
Neoplasms
Combined treatment of ulinastatin and tranexamic Acid provides beneficial effects by inhibiting inflammatory and fibrinolytic response in patients undergoing heart valve replacement surgery.
Neoplasms
Comparative Analysis of Clinical Parameters and Sputum Biomarkers in Establishing the Relevance of Filamentous Fungi in Cystic Fibrosis.
Neoplasms
Comparative Study on Pulmonary Toxicity in Mice Induced by Exposure to Unflavoured and Apple- and Strawberry-Flavoured Tobacco Waterpipe Smoke.
Neoplasms
Comparison of therapeutic effects between topical 8-oxo-2'-deoxyguanosine and corticosteroid in ocular alkali burn model.
Neoplasms
Cord blood cytokines and soluble adhesion molecules in vaginal and cesarean delivered neonates.
Neoplasms
Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of ?1-antitrypsin in lung cancer.
Neoplasms
Cytokine concentrations and neutrophil elastase activity in bronchoalveolar lavage and induced sputum from patients with cystic fibrosis, mild asthma and healthy volunteers.
Neoplasms
Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase.
Neoplasms
Direct interaction between caffeic acid phenethyl ester and human neutrophil elastase inhibits the growth and migration of PANC-1 cells.
Neoplasms
Effect of cardiopulmonary bypass on systemic release of neutrophil elastase and tumor necrosis factor.
Neoplasms
Effect of clarithromycin on airway obstruction and inflammatory markers in induced sputum in cystic fibrosis: a pilot study.
Neoplasms
Effect of ex vivo extracorporeal membrane oxygenation flow dynamics on immune response.
Neoplasms
Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor.
Neoplasms
Effect of sputum processing with dithiothreitol on the detection of inflammatory mediators in chronic bronchitis and bronchiectasis.
Neoplasms
Effect of ulinastatin on interleukins and pulmonary function in bypass patients: a meta-analysis of randomized controlled trials.
Neoplasms
Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs.
Neoplasms
Effects of granulocyte colony-stimulating factor (G-CSF) and neutrophil elastase inhibitor (ONO-5046) on acid-induced lung injury in rats.
Neoplasms
Effects of high-dose ulinastatin on inflammatory response and pulmonary function in patients with type-A aortic dissection after cardiopulmonary bypass under deep hypothermic circulatory arrest.
Neoplasms
Effects of peritonitis exudates on chemotaxis and phagocytosis of human neutrophils.
Neoplasms
Effects of ulinastatin treatment on the cardiopulmonary bypass-induced hemodynamic instability and pulmonary dysfunction.
Neoplasms
Effects of urinary protease inhibitor on inflammatory response during on-pump coronary revascularisation. Effect of ulinastatin on inflammatory response.
Neoplasms
Efficacy of ultrafiltration in removing inflammatory mediators during pediatric cardiac operations.
Neoplasms
EGCG reverses human neutrophil elastase-induced migration in A549 cells by directly binding to HNE and by regulating ?1-AT.
Neoplasms
Elafin is induced in epidermis in skin disorders with dermal neutrophilic infiltration: interleukin-1 beta and tumour necrosis factor-alpha stimulate its secretion in vitro.
Neoplasms
Elastase expression by infiltrating neutrophils in gliomas.
Neoplasms
Elastase inhibition assay with peptide substrates - an example for the limited comparability of in vitro results.
Neoplasms
Electrochemical sensing of human neutrophil elastase and polymorphonuclear neutrophil activity.
Neoplasms
Elevated expression of polymorphonuclear leukocyte elastase in breast cancer tissue is associated with tamoxifen failure in patients with advanced disease.
Neoplasms
Elevated neutrophil elastase and acrolein-protein adducts are associated with W256 regression.
Neoplasms
Elevation of cytokines during open heart surgery with cardiopulmonary bypass: participation of interleukin 8 and 6 in reperfusion injury.
Neoplasms
Endothelial cells and extracellular calmodulin inhibit monocyte tumor necrosis factor release and augment neutrophil elastase release.
Neoplasms
Endothelial Progenitor Cells Attenuate Ventilator-Induced Lung Injury with Large-Volume Ventilation.
Neoplasms
Enzyme-activatable imaging probe reveals enhanced neutrophil elastase activity in tumors following photodynamic therapy.
Neoplasms
Epigenetic Suppression of SERPINB1 Promotes Inflammation-Mediated Prostate Cancer Progression.
Neoplasms
Establishment and characterization of an arsenic-sensitive monoblastic leukaemia cell line (SigM5).
Neoplasms
Estrogen maintains myometrial tumors in a lymphangioleiomyomatosis model.
Neoplasms
Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Increased interleukin-1, tumor necrosis factor-?, PMN-elastase, lysozyme and neopterin.
Neoplasms
Evolution of pulmonary inflammation and nutritional status in infants and young children with cystic fibrosis.
Neoplasms
Expression of transforming growth factor-beta1 and tumour necrosis factor-alpha in bronchoalveolar lavage cells in murine pulmonary fibrosis after intraperitoneal administration of bleomycin.
Neoplasms
Faecal parameters in the assessment of activity in inflammatory bowel disease.
Neoplasms
Free-form neutrophil elastase is an independent marker predicting recurrence in primary breast cancer.
Neoplasms
Genomic analysis of the prognostic effect of tumor-associated neutrophil-related genes across 15 solid cancer types: an immune perspective.
Neoplasms
Glutamine-enhanced bacterial killing by neutrophils from postoperative patients.
Neoplasms
Glycoproteomic analysis of bronchoalveolar lavage (BAL) fluid identifies tumor-associated glycoproteins from lung adenocarcinoma.
Neoplasms
Granulocyte elastase, tumor necrosis factor-alpha and urokinase levels as prognostic markers in severe infection.
Neoplasms
Granulocyte-colony stimulating factor enhances chimeric antibody Nd2 dependent cytotoxicity against pancreatic cancer mediated by polymorphonuclear neutrophils.
Neoplasms
Growth effect of neutrophil elastase on breast cancer: favorable action of sivelestat and application to anti-HER2 therapy.
Neoplasms
High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis.
Neoplasms
High-dose antithrombin III treatment of severely injured patients: results of a prospective study.
Neoplasms
Histidine-Rich Glycoprotein Suppresses Hyperinflammatory Responses of Lung in a Severe Acute Pancreatitis Mouse Model.
Neoplasms
Human colon carcinoma cells synthesize and secrete alpha 1-proteinase inhibitor.
Neoplasms
Human gingival derived neuronal cells in the optimized caffeic acid hydrogel for hemitransection spinal cord injury model.
Neoplasms
Human leukocyte elastase counteracts matrix metalloproteinase-7 induced apoptosis resistance of tumor cells.
Neoplasms
Human neutrophil elastase degrades inter-alpha-trypsin inhibitor to liberate urinary trypsin inhibitor related proteins.
Neoplasms
Human neutrophil elastase induces MUC5AC overexpression in chronic rhinosinusitis through tumour necrosis factor-? converting enzyme.
Neoplasms
Human Neutrophil Elastase Mediates MUC5AC Hypersecretion via the Tumour Necrosis Factor-? Converting Enzyme-Epidermal Growth Factor Receptor Signalling Pathway in vivo.
Neoplasms
Human neutrophil elastase regulates the expression and secretion of elafin (elastase-specific inhibitor) in type II alveolar epithelial cells.
Neoplasms
Human neutrophil elastase releases a ligand-binding fragment from the 75-kDa tumor necrosis factor (TNF) receptor. Comparison with the proteolytic activity responsible for shedding of TNF receptors from stimulated neutrophils.
Neoplasms
Human tumor cell urokinase-type plasminogen activator (uPA): degradation of the proenzyme form (pro-uPA) by granulocyte elastase prevents subsequent activation by plasmin.
Neoplasms
Identification of novel functional sequence variants in the gene for peptidase inhibitor 3.
Neoplasms
IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation.
Neoplasms
Impact of sputum bacteria on airway inflammation and health status in clinical stable COPD.
Neoplasms
Inactivation of human tumor cell pro-urokinase by granulocyte elastase.
Neoplasms
Increased matrix metalloproteinase-9 (MMP-9) activity observed in chronic wound fluid is related to the clinical severity of the ulcer.
Neoplasms
Induced sputum in cystic fibrosis: within-week reproducibility of inflammatory markers.
Neoplasms
Inflammatory markers in cystic fibrosis patients with transmissible Pseudomonas aeruginosa.
Neoplasms
Inflammatory mediators in adults undergoing cardiopulmonary bypass: comparison of centrifugal and roller pumps.
Neoplasms
Inflammatory profile of new bacterial strain exacerbations of chronic obstructive pulmonary disease.
Neoplasms
Inflammatory response after implantation of a left ventricular assist device: comparison between the axial flow MicroMed DeBakey VAD and the pulsatile Novacor device.
Neoplasms
Influence of a human protease inhibitor on surgical stress induced immunosuppression.
Neoplasms
Inhibition of matrix-proteases by polyphenols: chemical insights for anti-inflammatory and anti-invasion drug design.
Neoplasms
Inhibition of neutrophil elastase suppresses the development of skin tumors in hairless mice.
Neoplasms
Insulin Receptor Substrate Regulation of Phosphoinositol-3 Kinase.
Neoplasms
Interleukin-1beta, tumor necrosis factor-alpha levels and neutrophil elastase activity in peri-implant crevicular fluid.
Neoplasms
Involvement of a serine protease, but not of neutrophil elastase, in tumor necrosis factor-induced lethal hepatitis and induction of platelet-activating factor.
Neoplasms
Latency of cathepsin B secreted by human colon carcinoma cells is not linked to secretion of cystatin C and is relieved by neutrophil elastase.
Neoplasms
Leukocyte/endothelium activation and interactions during femoral percutaneous transluminal angioplasty.
Neoplasms
Local increase in polymorphonuclear leukocyte elastase is associated with tumor invasiveness in non-small cell lung cancer.
Neoplasms
Lower airway inflammation in infants with cystic fibrosis detected by newborn screening.
Neoplasms
LTB4 is present in exudative pleural effusions and contributes actively to neutrophil recruitment in the inflamed pleural space.
Neoplasms
Matrix proteases, green tea, and St. John's wort: biomedical research catches up with folk medicine.
Neoplasms
Monoclonal antibody to tumor necrosis factor--alpha prevents lethal endotoxin sepsis in adult rhesus monkeys.
Neoplasms
N-acetylcysteine attenuates acute lung injury induced by fat embolism.
Neoplasms
NET-producing CD16(high) CD62L(dim) neutrophils migrate to tumor sites and predict improved survival in patients with HNSCC.
Neoplasms
Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells.
Neoplasms
Neutrophil and cytokine activation with neonatal extracorporeal membrane oxygenation.
Neoplasms
Neutrophil and nonneutrophil-mediated injury in intestinal ischemia-reperfusion.
Neoplasms
Neutrophil apoptosis, proinflammatory mediators and cell counts in bronchiectasis.
Neoplasms
Neutrophil elastase activity in pulmonary venous blood during lung resection.
Neoplasms
Neutrophil elastase and cancer.
Neoplasms
Neutrophil Elastase and Neutrophil Extracellular Traps in the Tumor Microenvironment.
Neoplasms
Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers.
Neoplasms
Neutrophil elastase enhances antigen presentation by upregulating human leukocyte antigen class I expression on tumor cells.
Neoplasms
Neutrophil Elastase Facilitates Tumor Cell Intravasation and Early Metastatic Events.
Neoplasms
Neutrophil elastase from myeloid cells promotes TSC2-null tumor growth.
Neoplasms
Neutrophil elastase in the tumor microenvironment.
Neoplasms
Neutrophil elastase inhibitor (sivelestat) attenuates subsequent ventilator-induced lung injury in mice.
Neoplasms
Neutrophil elastase inhibitor (sivelestat) preserves antitumor immunity and reduces the inflammatory mediators associated with major surgery.
Neoplasms
Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis.
Neoplasms
Neutrophil elastase-dependent cleavage compromises the tumor suppressor role of EMILIN1.
Neoplasms
Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth.
Neoplasms
Neutrophil elastase-mediated proteolysis of the tumor suppressor p200 CUX1 promotes cell proliferation and inhibits cell differentiation in APL.
Neoplasms
Neutrophil Extracellular Traps Associate with Clinical Stages in Breast Cancer.
Neoplasms
Neutrophil Extracellular Traps Drive Mitochondrial Homeostasis in Tumors to Augment Growth.
Neoplasms
Neutrophil Granulocytes in Ovarian Cancer - Induction of Epithelial-To-Mesenchymal-Transition and Tumor Cell Migration.
Neoplasms
Normothermia has beneficial effects in cardiopulmonary bypass attenuating inflammatory reactions.
Neoplasms
Olive oil-induced reduction of oxidative damage and inflammation promotes wound healing of pressure ulcers in mice.
Neoplasms
Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist.
Neoplasms
Parecoxib reduced ventilation induced lung injury in acute respiratory distress syndrome.
Neoplasms
Perioperative pattern of peritoneal interleukin 8, tumour necrosis factor-alpha, and granulocyte elastase release in human secondary peritonitis.
Neoplasms
Perioperative use of a neutrophil elastase inhibitor in video-assisted thoracoscopic oesophagectomy for cancer.
Neoplasms
Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-alpha and neutrophil elastase.
Neoplasms
Phosphonic pseudopeptides as human neutrophil elastase inhibitors--a combinatorial approach.
Neoplasms
Phosphorylcholine or heparin coating for pediatric extracorporeal circulation causes similar biologic effects in neonates and infants.
Neoplasms
Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide?induced pulmonary inflammation by inhibiting interleukin?8 production and NF??B activation.
Neoplasms
Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer.
Neoplasms
Platelets protect lung from injury induced by systemic inflammatory response.
Neoplasms
Pleural fluid tests to identify complicated parapneumonic effusions.
Neoplasms
Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats.
Neoplasms
Premobilization of CD133+ progenitors is associated with attenuated inflammation-induced pulmonary dysfunction following extracorporeal circulation in mice.
Neoplasms
Prognostic significance of immunoreactive neutrophil elastase in human breast cancer: long-term follow-up results in 313 patients.
Neoplasms
Prognostic significance of three novel biologic factors in a clinical trial of adjuvant therapy for node-negative breast cancer.
Neoplasms
Proteases and emphysema.
Neoplasms
Recent Trends in the Design, Synthesis and Biological Exploration of ?-Lactams.
Neoplasms
Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD.
Neoplasms
Relationship between airway colonization, inflammation and exacerbation frequency in COPD.
Neoplasms
Relationship between respiratory distress and cytokine response after cardiopulmonary bypass.
Neoplasms
Release of cytokines, polymorphonuclear elastase and terminal C5b-9 complement complex by infusion of wound drainage blood.
Neoplasms
Release of interleukin-8, interleukin-6, and colony-stimulating factors by upper airway epithelial cells: implications for cystic fibrosis.
Neoplasms
Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils.
Neoplasms
Role of imbalance between neutrophil elastase and alpha 1-antitrypsin in cancer development and progression.
Neoplasms
Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases.
Neoplasms
Role of neutrophil extracellular traps in regulation of lung cancer invasion and metastasis: Structural insights from a computational model.
Neoplasms
Role of neutrophils in mucus hypersecretion in COPD and implications for therapy.
Neoplasms
Serine Proteases Enhance Immunogenic Antigen Presentation on Lung Cancer Cells.
Neoplasms
Sputum and salivary protein biomarkers and point-of-care biosensors for the management of COPD.
Neoplasms
Systemic inflammation in chronic obstructive pulmonary disease and asthma: Similarities and differences.
Neoplasms
Systemic release of neutrophil elastase and tumour necrosis factor alpha following ABO incompatible blood transfusion.
Neoplasms
The anti-inflammatory effects of ulinastatin in trauma patients with hemorrhagic shock.
Neoplasms
The effect of oral clarithromycin on bronchial airway inflammation in moderate-to-severe stable COPD: a randomized controlled trial.
Neoplasms
The Effects of Leukocyte Filtration on Cell Salvaged Autologous Blood Transfusion on Lung Function and Lung Inflammatory and Oxidative Stress Reactions in Elderly Patients Undergoing Lumbar Spinal Surgery.
Neoplasms
The host inflammatory response prior to death in patients with cystic fibrosis and chronic Pseudomonas aeruginosa infection.
Neoplasms
The Immunomodulatory Effects of Macrolides-A Systematic Review of the Underlying Mechanisms.
Neoplasms
The mechanism of hepatic cellular injury in sepsis: an in vitro study of the implications of cytokines and neutrophils in its pathogenesis.
Neoplasms
The Neutrophil Elastase Inhibitor Sivelestat Suppresses Accelerated Gastrointestinal Tumor Growth via Peritonitis After Cecal Ligation and Puncture.
Neoplasms
The prognostic value of polymorphonuclear leukocyte elastase in patients with primary breast cancer.
Neoplasms
The role of neutrophil death in chronic inflammation and cancer.
Neoplasms
The Serine Protease Neutrophil Elastase Selectively Kills Tumor Cells.
Neoplasms
Transplantation of Endothelial Progenitor Cells Attenuates Lipopolysaccharide-Induced Lung Injury via Inhibiting the Inflammatory Secretion of Neutrophils in Rats.
Neoplasms
Trehalose does not affect the functions of human neutrophils in vitro.
Neoplasms
Tumor cell recognition by lymphocytes: is the MHC always essential?
Neoplasms
Tumor neutrophil elastase is closely associated with the direct extension of non-small cell lung cancer into the aorta.
Neoplasms
Upregulation of adhesion molecules in the bronchial mucosa of subjects with chronic obstructive bronchitis.
Neoplasms
Whole blood model of meningococcal bacteraemia--a method for exploring host-bacterial interactions.
Neoplasms
[Activation of endothelium in cardiac surgery: the circulating levels of soluble E-selectin as a marker of the activation of endothelium]
Neoplasms
[Alteration of serum levels of endotoxin, polymorphonuclear leukocyte elastase, and the molecular markers of the coagulation and fibrinolytic system in the patients with esophageal cancer and lung cancer before and following operation]
Neoplasms
[Characterization of structural and cellular components in pulmonary sarcoidosis granuloma]
Neoplasms
[Clinical benefits of using the phosphorylcholine coating of an extracorporeal circuit in babies weighing less than 5 kg].
Neoplasms
[Effect of heparin pretreatment on the level of neutrophil extracellular traps of serum and lung tissue in septic mice].
Neoplasms
[Effect of ulinastatin on perioperative inflammatory response to coronary artery bypass grafting with cardiopulmonary bypass.]
Neoplasms
[Influence of cardiopulmonary bypass on biological response]
Neoplasms
[N01WA-735E, a human leukocyte elastase inhibitor from metabolites of microorganisms]
Neoplasms
[Neutrophil elastase in postoperative pleural effusion of patients who had undergone pulmonary resections]
Neoplasms
[Protective effects of ulinastatin on the lung injury during cardiopulmonary bypass]
Neoplasms
[Systemic inflammation in COPD and asthma: similarities and differences]
Neoplasms
[The relationship between opsonin, endotoxin and chemical mediators in postoperative complications after surgery]
Neoplasms
[Urokinase-type plasminogen activator as a predictor for lymph nodes metastasis of uterine cervical cancer]
Nephritis
Beneficial effect of neutrophil elastase inhibitor on anti-Thy1.1 nephritis in rats.
Nephritis
Effects of a novel elastase inhibitor, ONO-5046, on nephrotoxic serum nephritis in rats.
Nephritis
Murine lupus is neutrophil elastase-independent in the MRL.Faslpr model.
Neuralgia
Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice.
Neuralgia
Repurposing a leukocyte elastase inhibitor for neuropathic pain.
Neuralgia
The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
Neuroinflammatory Diseases
The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease.
Neutropenia
A Case of Cyclic Neutropenia and Associated Amyloidosis.
Neutropenia
A case of secondary acute myeloid leukemia on a background of glycogen storage disease with chronic neutropenia treated with granulocyte colony stimulating factor.
Neutropenia
A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation.
Neutropenia
A novel ELANE gene mutation in a patient with severe congenital neutropenia and intermittent thrombocytopenia.
Neutropenia
A Novel ELANE Mutation Associated with Inflammatory Arthritis, Defective NETosis, and Recurrent Parvoviral Infection.
Neutropenia
A Novel Homozygous HAX1 Mutation in a Child With Cyclic Neutropenia: A Case Report and Review.
Neutropenia
A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia.
Neutropenia
A Truncated Granulocyte Colony-stimulating Factor Receptor (G-CSFR) Inhibits Apoptosis Induced by Neutrophil Elastase G185R Mutant: IMPLICATION FOR UNDERSTANDING CSF3R GENE MUTATIONS IN SEVERE CONGENITAL NEUTROPENIA.
Neutropenia
Aberrant subcellular targeting of the G185R neutrophil elastase mutant associated with severe congenital neutropenia induces premature apoptosis of differentiating promyelocytes.
Neutropenia
Acquired cyclic neutropenia associated with cocaine-induced anti-neutrophil cytoplasmic antibodies binding to human neutrophil elastase.
Neutropenia
Activation of the unfolded protein response is associated with impaired granulopoiesis in transgenic mice expressing mutant Elane.
Neutropenia
Acute and chronic neutropenias. What is new?
Neutropenia
Allogeneic Transplant in ELANE and MEFV Mutation Positive Severe Cyclic Neutropenia: Review of Prognostic Factors for Secondary Severe Events.
Neutropenia
Bioinformatic analysis of protein structure-function relationships: case study of leukocyte elastase (ELA2) missense mutations.
Neutropenia
Bone marrow failure syndromes in children.
Neutropenia
Can mutations in ELA2, neutrophil elastase expression or differential cell toxicity explain sulphasalazine-induced agranulocytosis?
Neutropenia
Characterisation of Neutropenia-Associated Neutrophil Elastase Mutations in a Murine Differentiation Model In Vitro and In Vivo.
Neutropenia
Characterization of mutant neutrophil elastase in severe congenital neutropenia.
Neutropenia
Clinical characteristics of severe congenital neutropenia caused by novel ELANE gene mutations.
Neutropenia
Clinical implications of mutations of neutrophil elastase in congenital and cyclic neutropenia.
Neutropenia
Coexistence of sickle cell disease and severe congenital neutropenia: first impressions can be deceiving.
Neutropenia
Congenital Neutropenia Patient With Hypomorphic Biallelic CSF3R Mutation Responding to GCSF.
Neutropenia
Congenital neutropenia.
Neutropenia
Congenital neutropenia: diagnosis, molecular bases and patient management.
Neutropenia
Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase.
Neutropenia
Corticosteroid-binding globulin cleavage may be pathogen-dependent in bloodstream infection.
Neutropenia
CRISPR-Cas9-Mediated ELANE Mutation Correction in Hematopoietic Stem and Progenitor Cells to Treat Severe Congenital Neutropenia.
Neutropenia
CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients.
Neutropenia
Current insights into inherited bone marrow failure syndromes.
Neutropenia
Cyclic and chronic neutropenia.
Neutropenia
Cyclic neutropenia and severe congenital neutropenia in patients with a shared ELANE mutation and paternal haplotype: evidence for phenotype determination by modifying genes.
Neutropenia
Cyclic neutropenia associated with T cell immunity to granulocyte proteases and a double de novo mutation in GFI1, a transcriptional regulator of ELANE.
Neutropenia
Cyclic Neutropenia From a Novel Mutation Ala57Asp of ELANE: Phenotypic Variability in Neutropenia From Mutated Ala57 Residue.
Neutropenia
Cyclic neutropenia with a novel gene mutation presenting with a necrotizing soft tissue infection and severe sepsis: case report.
Neutropenia
Cyclic neutropenia.
Neutropenia
Defective G-CSFR signaling pathways in congenital neutropenia.
Neutropenia
Description of an ELANE Mutation in a Girl with Severe Congenital Neutropenia: A Paradigm of Targeted Genetic Screening Based on Clinical Findings.
Neutropenia
Different Clinical Phenotypes in Familial Severe Congenital Neutropenia Cases with Same Mutation of the ELANE Gene.
Neutropenia
Dissecting ELANE neutropenia pathogenicity by human HSC gene editing.
Neutropenia
Double de novo mutations of ELA2 in cyclic and severe congenital neutropenia.
Neutropenia
Double de novo mutations of ELANE (ELA2) in a patient with severe congenital neutropenia requiring high-dose G-CSF therapy.
Neutropenia
Ela2 mutations and clinical manifestations in familial congenital neutropenia.
Neutropenia
ELANE gene mutation-induced cyclic neutropenia manifesting as recurrent fever with oral mucosal ulcer: A case report.
Neutropenia
ELANE mutant-specific activation of different UPR pathways in congenital neutropenia.
Neutropenia
ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology.
Neutropenia
Elastase inhibitors as potential therapies for ELANE-associated neutropenia.
Neutropenia
Enzyme-Agnostic Lysosomal Screen Identifies New Legumain-Cleavable ADC Linkers.
Neutropenia
Four novel ELANE mutations in patients with congenital neutropenia.
Neutropenia
Functional characteristics of circulating granulocytes in severe congenital neutropenia caused by ELANE mutations.
Neutropenia
Functional interaction between mutations in the granulocyte colony-stimulating factor receptor in severe congenital neutropenia.
Neutropenia
G-CSF receptor mutations in patients with congenital neutropenia.
Neutropenia
Generation and characterization of a human iPSC line SANi007-A from a patient with a heterozygous dominant mutation in ELANE.
Neutropenia
Genetic heterogeneity in severe congenital neutropenia: how many aberrant pathways can kill a neutrophil?
Neutropenia
Genetics and pathophysiology of severe congenital neutropenia syndromes unrelated to neutrophil elastase.
Neutropenia
HEMATOGONES IN A PERIPEHRAL BLOOD OF A 51/2-MONTH-OLD BOY WITH CYCLIC NEUTROPENIA DUE TO HETEROZYGOUS NOVEL ELANE GENE MUTATION p.Q97P, c.290 A>C.
Neutropenia
Hereditary neutropenia: dogs explain human neutrophil elastase mutations.
Neutropenia
Homozygous c.130-131 ins A (pW44X) mutation in the HAX1 gene as the most common cause of congenital neutropenia in Turkey: Report from the Turkish Severe Congenital Neutropenia Registry.
Neutropenia
HSCT may lower leukemia risk in ELANE neutropenia: a before-after study from the French Severe Congenital Neutropenia Registry.
Neutropenia
Human leukocyte elastase gene expression is regulated by PU.1 in conjunction with closely associated cytidine-rich and Myb binding sites.
Neutropenia
Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia.
Neutropenia
Inducible expression of a disease-associated ELANE mutation impairs granulocytic differentiation, without eliciting an unfolded protein response.
Neutropenia
Inherited Neutrophil Disorders: Molecular Basis and New Therapies.
Neutropenia
Inhibition of neutrophil elastase contributes to attenuation of lipopolysaccharide-induced acute lung injury during neutropenia recovery in mice.
Neutropenia
Kostmann syndrome or infantile genetic agranulocytosis, part two: Understanding the underlying genetic defects in severe congenital neutropenia.
Neutropenia
Lymphoid enhancer factor-1 links two hereditary leukemia syndromes through core-binding factor alpha regulation of ELA2.
Neutropenia
Management of tooth extraction in a patient with ELANE gene mutation-induced cyclic neutropenia: A case report.
Neutropenia
Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis.
Neutropenia
Molecular basis and therapy of disorders associated with chronic neutropenia.
Neutropenia
Molecular screening of the neutrophil elastase gene in congenital neutropenia.
Neutropenia
Mosaicism of an ELANE mutation in an asymptomatic mother in a familial case of cyclic neutropenia.
Neutropenia
Mosaicism of an ELANE Mutation in an Asymptomatic Mother.
Neutropenia
Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase.
Neutropenia
Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response.
Neutropenia
Mutations in the ELA2 gene correlate with more severe expression of neutropenia: a study of 81 patients from the French Neutropenia Register.
Neutropenia
Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease.
Neutropenia
Mutations in the ELANE Gene are Associated with Development of Periodontitis in Patients with Severe Congenital Neutropenia.
Neutropenia
Mutations in the gene encoding neutrophil elastase (ELA2) are not sufficient to cause the phenotype of congenital neutropenia.
Neutropenia
Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia.
Neutropenia
Mutations in the neutrophil elastase gene in cyclic and congenital neutropenia.
Neutropenia
Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis.
Neutropenia
Neutropenia in 6 ethnic groups from the Caribbean and the U.S.
Neutropenia
Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms.
Neutropenia
Neutrophil and nonneutrophil-mediated injury in intestinal ischemia-reperfusion.
Neutropenia
Neutrophil elastase and granulocyte colony-stimulating factor receptor mutation analyses and leukemia evolution in severe congenital neutropenia patients belonging to the original Kostmann family in northern Sweden.
Neutropenia
Neutrophil elastase converts human immature dendritic cells into transforming growth factor-beta1-secreting cells and reduces allostimulatory ability.
Neutropenia
Neutrophil Elastase Defects in Congenital Neutropenia.
Neutropenia
Neutrophil elastase depends on serglycin proteoglycan for localization in granules.
Neutropenia
Neutrophil elastase gene mutations in cyclic neutropenia.
Neutropenia
Neutrophil elastase in cyclic and severe congenital neutropenia.
Neutropenia
Neutrophil elastase is associated with serglycin on its way to lysosomes in U937 cells.
Neutropenia
Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1.
Neutropenia
Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia.
Neutropenia
Neutrophil elastase mutations in congenital neutropenia.
Neutropenia
Neutrophil elastase mutations in severe congenital neutropenia patients of the original Kostmann family.
Neutropenia
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.
Neutropenia
Neutrophil elastase-processing defect in cyclic hematopoietic dogs.
Neutropenia
Neutrophil extracellular traps as a potential source of autoantigen in cocaine-associated autoimmunity.
Neutropenia
Novel ELANE gene mutation in a Korean girl with severe congenital neutropenia.
Neutropenia
Novel ELANE Gene Mutation in a Newborn with Severe Congenital Neutropenia: Case Report and Literature Review.
Neutropenia
Novel insights from adaptor protein 3 complex deficiency.
Neutropenia
Outcome and management of pregnancies in severe chronic neutropenia patients by the European Branch of the Severe Chronic Neutropenia International Registry.
Neutropenia
Paternal mosaicism proves the pathogenic nature of mutations in neutrophil elastase in severe congenital neutropenia.
Neutropenia
Paternal Somatic Mosaicism of a Novel Frameshift Mutation in ELANE Causing Severe Congenital Neutropenia.
Neutropenia
Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.
Neutropenia
Plasma neutrophil-activating peptide-1/interleukin-8 and neutrophil elastase in a primate bacteremia model.
Neutropenia
PML-controlled responses in severe congenital neutropenia with ELANE-misfolding mutations.
Neutropenia
Prevalence of mutations in ELANE, GFI1, HAX1, SBDS, WAS and G6PC3 in patients with severe congenital neutropenia.
Neutropenia
Role of CSF3R mutations in the pathomechanism of congenital neutropenia and secondary acute myeloid leukemia.
Neutropenia
Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone hypothesis.
Neutropenia
Screening of genetic variants in ELANE mutation negative congenital neutropenia by next generation sequencing.
Neutropenia
Severe congenital neutropenia and the unfolded protein response.
Neutropenia
Severe congenital neutropenia associated with the ELANE gene in Chinese children: case report.
Neutropenia
Severe congenital neutropenia caused by the ELANE gene mutation in a Vietnamese boy with misdiagnosis of tuberculosis and autoimmune neutropenia: a case report.
Neutropenia
Severe congenital neutropenia in a multigenerational family with a novel neutrophil elastase (ELANE) mutation.
Neutropenia
Severe congenital neutropenia with a novel ELANE mutation in 2 Mexican patients.
Neutropenia
Severe congenital neutropenia, a genetically heterogeneous disease group with an increased risk of AML/MDS.
Neutropenia
Severe congenital neutropenia: a negative synergistic effect of multiple mutations of ELANE (ELA2) gene.
Neutropenia
Severe congenital neutropenia: inheritance and pathophysiology.
Neutropenia
Severe congenital neutropenia: new lane for ELANE.
Neutropenia
Significance of neutrophil elastase mutations versus G-CSF receptor mutations for leukemic progression of congenital neutropenia.
Neutropenia
Spectrum of ELANE mutations in congenital neutropenia: a single-centre study in patients of Indian origin.
Neutropenia
Stage specific gene expression of serpins and their cognate proteases during myeloid differentiation.
Neutropenia
Successful treatment with allogenic hematopoietic stem cell transplantation of a severe congenital neutropenia patient harboring a novel ELANE mutation.
Neutropenia
The diversity of mutations and clinical outcomes for ELANE-associated neutropenia.
Neutropenia
The role of apoptosis in the pathophysiology of chronic neutropenias associated with bone marrow failure.
Neutropenia
The Severe Chronic Neutropenia International Registry: 10-Year Follow-up Report.
Neutropenia
The Spectrum of ELANE Mutations and their Implications in Severe Congenital and Cyclic Neutropenia.
Neutropenia
Three patients with glucose-6 phosphatase catalytic subunit 3 deficiency.
Neutropenia
Two paternal mosaicism of mutation in ELANE causing severe congenital neutropenia exhibit normal neutrophil morphology and ROS production.
Neutropenia
White blood cell defects: molecular discoveries and clinical management.
Neutropenia
[A case report of cyclic neutropenia caused by novel double ELANE gene mutations].
Neutropenia
[Clinical and genetic analysis of four patients with congenital neutropenia].
Neutropenia
[Clinical and genetic analysis of two patients with congenital neutropenia caused by ELANE gene mutation].
Neutropenia
[Cyclic neutropenia. Detection of a mutation in the gene for neutrophil elastase (ELA2)]
Neutropenia
[Granulopoeisis and leukemogenesis : lessons from congenital neutropenia.]
Neutropenia
[Mutations of the ELANE gene cause severe congenital neutropenia with periodontal disease: a case report].
Non-alcoholic Fatty Liver Disease
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
Non-alcoholic Fatty Liver Disease
Increased ratio of neutrophil elastase to ?1-antitrypsin is closely associated with liver inflammation in patients with nonalcoholic steatohepatitis.
Non-alcoholic Fatty Liver Disease
Knockout of neutrophil elastase protects against western diet induced nonalcoholic steatohepatitis in mice by regulating hepatic ceramides metabolism.
Non-alcoholic Fatty Liver Disease
Mice Deficient in the IL-1? Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD.
Non-alcoholic Fatty Liver Disease
Neutrophils Play a Crucial Role in the Early Stage of Nonalcoholic Steatohepatitis via Neutrophil Elastase in Mice.
Non-alcoholic Fatty Liver Disease
[Sivelestat alleviates nonalcoholic steatohepatitis in mice through inhibiting activation of Kupffer cells].
Obesity
Imbalance between neutrophil elastase and its inhibitor ?1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure.
Obesity
Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects.
Obesity
Neutrophil Elastase Regulates Emergency Myelopoiesis Preceding Systemic Inflammation in Diet-induced Obesity.
Obesity
Surgical site peptidylarginine deaminase 4 (PAD4), a biomarker of NETosis, correlates with insulin resistance in total joint arthroplasty patients: A preliminary report.
Obstetric Labor, Premature
Changes in polymorphonuclear leukocytes in the vagina of patients with preterm labor.
Obstetric Labor, Premature
Effect of urinary trypsin inhibitor on preterm labor with high granulocyte elastase concentration in cervical secretions.
Obstetric Labor, Premature
How to lower perinatal mortality? Perinatal care in Japan.
Obstetric Labor, Premature
Increased level of granulocyte elastase in cervical secretion is an independent predictive factor for preterm delivery.
Obstetric Labor, Premature
Initial experience using Sivelestat to manage preterm labor with a bulging fetal membrane in pregnant women.
Obstetric Labor, Premature
Matrix Metalloprotease-1 and Elastase Are Novel Uterotonic Agents Acting Through Protease-Activated Receptor 1.
Oropharyngeal Neoplasms
Oxidative stress, neutrophil elastase and IGFBP7 levels in patients with oropharyngeal cancer and chronic periodontitis.
Osteoarthritis
Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis.
Osteoarthritis
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Osteoarthritis
Neutrophil Elastase Induces Chondrocyte Apoptosis and Facilitates the Occurrence of Osteoarthritis via Caspase Signaling Pathway.
Osteoarthritis
Quantitation of human leukocyte elastase, cathepsin G, alpha-2-macroglobulin and alpha-1-proteinase inhibitor in osteoarthrosis and rheumatoid arthritis synovial fluids.
Osteoarthritis
The distribution of enzyme inhibitors in the joint in rheumatoid and experimental arthritis.
Osteomyelitis
PMN elastase in bone and joint infections.
Osteomyelitis
[PMN-elastase as a marker in diagnosis and follow-up of bone and joint infections]
Otitis Externa
Inflammatory proteases in chronic otitis externa.
Otitis Media
Neutrophil elastase and its complex with alpha 1-antitrypsin in the pathogenesis of chronic suppurative otitis media.
Otitis Media with Effusion
Neutrophil elastase and its complex with alpha 1-antitrypsin in the pathogenesis of chronic suppurative otitis media.
Otitis Media, Suppurative
Neutrophil elastase and its complex with alpha 1-antitrypsin in the pathogenesis of chronic suppurative otitis media.
Otitis Media, Suppurative
Treatment with a neutrophil elastase inhibitor and ofloxacin reduces P. aeruginosa burden in a mouse model of chronic suppurative otitis media.
Out-of-Hospital Cardiac Arrest
Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock.
Out-of-Hospital Cardiac Arrest
Insufficient production of urinary trypsin inhibitor for neutrophil elastase release after cardiac arrest.
Out-of-Hospital Cardiac Arrest
Out-of-hospital cardiac arrest increases soluble vascular endothelial adhesion molecules and neutrophil elastase associated with endothelial injury.
Ovarian Neoplasms
Overexpression of protease inhibitor-dead secretory leukocyte protease inhibitor causes more aggressive ovarian cancer in vitro and in vivo.
Overweight
Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects.
Pancreatic Neoplasms
Pancreatic elastase IIIA and its variants are expressed in pancreatic carcinoma cells.
Pancreatic Neoplasms
[New aspects of the diagnosis of pancreatic cancer by determination of granulocyte elastase]
Pancreatitis
Activation of cellular immune response in acute pancreatitis.
Pancreatitis
Activity of neutrophil elastase reflects the progression of acute pancreatitis.
Pancreatitis
An impaired phagocytic function is associated with leucocyte activation in the early stages of severe acute pancreatitis.
Pancreatitis
Changes in polymorphonuclear neutrophil-elastase in pancreatitis.
Pancreatitis
Changes in serum amylase, lipase and leukocyte elastase during diabetic ketoacidosis and poorly controlled diabetes.
Pancreatitis
Clinical value of an automated granulocyte elastase assay in predicting severity of acute pancreatitis.
Pancreatitis
Combined effects of sivelestat and resveratrol on severe acute pancreatitis-associated lung injury in rats.
Pancreatitis
Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin.
Pancreatitis
Early diagnosis of a pancreatic abscess in acute pancreatitis.
Pancreatitis
Extracellular cleavage of E-cadherin by leukocyte elastase during acute experimental pancreatitis in rats.
Pancreatitis
Granulocyte elastase in assessment of severity of acute pancreatitis. Comparison with acute-phase proteins C-reactive protein, alpha 1-antitrypsin, and protease inhibitor alpha 2-macroglobulin.
Pancreatitis
Inflammatory mediators and cytokines--new aspects of the pathophysiology and assessment of severity of acute pancreatitis?
Pancreatitis
Inflammatory response in the early prediction of severity in human acute pancreatitis.
Pancreatitis
Laboratory markers of severe acute pancreatitis.
Pancreatitis
Leukocyte elastase alpha 1-proteinase inhibitor complexes may diagnose pancreatic abscesses early.
Pancreatitis
Levels of leukocyte proteases in plasma and peritoneal exudate in severe, acute pancreatitis.
Pancreatitis
Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis.
Pancreatitis
PMN-elastase in comparison with CRP, antiproteases, and LDH as indicators of necrosis in human acute pancreatitis.
Pancreatitis
Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats.
Pancreatitis
Protective effect of the combined treatment of pancreatic and neutrophil elastase inhibitors on acute pancreatitis elicited by lipopolysaccharide in rats given intraductal injection of taurocholate plus trypsin.
Pancreatitis
Protective effects of a PAF receptor antagonist and a neutrophil elastase inhibitor on multiple organ failure induced by cerulein plus lipopolysaccharide in rats.
Pancreatitis
Release of immunoreactive canine leukocyte elastase normally and in endotoxin and pancreatitic shock.
Pancreatitis
Renoprotective activity of sivelestat in severe acute pancreatitis in rats.
Pancreatitis
Significance of endothelial molecular markers in the evaluation of the severity of acute pancreatitis.
Pancreatitis
Surgical strategies in acute pancreatitis.
Pancreatitis
The effects of a new human leukocyte elastase inhibitor (recombinant guamerin) on cerulein-induced pancreatitis in rats.
Pancreatitis
[Inflammatory mediators in the acute pancreatitis]
Pancreatitis
[Influences of BN50739 on neutrophil elastase and phospholipase A2 in lung and tracheal mucosa of pigs with acute severe pancreatitis]
Pancreatitis
[Technique and outcome of surgical therapy in acute pancreatitis]
Pancreatitis
[Use of the urinary trypsin inhibitor ulinastatin for acute Kawasaki disease].
Pancreatitis, Acute Hemorrhagic
Effect of a specific synthetic inhibitor of neutrophil elastase (ONO-5046) on the course of acute hemorrhagic pancreatitis in dogs.
Pancreatitis, Acute Hemorrhagic
[Problems in intensive care posed by imbalance in the protease--protease inhibitor system]
Pancreatitis, Acute Necrotizing
Clinical picture and diagnosis of acute pancreatitis.
Parasitemia
Low levels of fibrin-stabilizing factor (factor XIII) in human Plasmodium falciparum malaria: correlation with clinical severity.
Pemphigoid, Bullous
A comparative study of expression of Fc receptors in relation to the autoantibody-mediated immune response and neutrophil elastase expression in autoimmune blistering dermatoses.
Pemphigoid, Bullous
A critical role for neutrophil elastase in experimental bullous pemphigoid.
Pemphigoid, Bullous
Basement membrane zone as a target for human neutrophil elastase in psoriasis.
Pemphigoid, Bullous
Collagen XVII Processing and Blistering Skin Diseases.
Pemphigoid, Bullous
Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid.
Pemphigoid, Bullous
Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoid.
Pemphigoid, Bullous
The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo.
Pemphigus
A comparative study of expression of Fc receptors in relation to the autoantibody-mediated immune response and neutrophil elastase expression in autoimmune blistering dermatoses.
Periodontal Diseases
Active and alpha-1 proteinase inhibitor complexed leukocyte elastase levels in crevicular fluid from patients with periodontal diseases.
Periodontal Diseases
Chemically modified tetracycline-3 (CMT-3): A novel inhibitor of the serine proteinase, elastase.
Periodontal Diseases
Degradation of noncollagenous components by neutrophil elastase reduces the mechanical strength of rat periodontal ligament.
Periodontal Diseases
Granulocyte elastase activity and PGE2 levels in gingival crevicular fluid in relation to the presence of subgingival periodontopathogens in subjects with untreated adult periodontitis.
Periodontal Diseases
Influence of combinations of bacteria on the levels of prostaglandin E2, interleukin-1beta, and granulocyte elastase in gingival crevicular fluid and on the severity of periodontal disease.
Periodontal Diseases
Neutrophil elastase is involved in the initial destruction of human periodontal ligament.
Periodontal Diseases
Periodontal Disease in Patients From the Original Kostmann Family With Severe Congenital Neutropenia.
Periodontal Diseases
Proinflammatory cytokines production and PMN-elastase release from activated PMN cells in the periodontal disease.
Periodontal Diseases
Purification and characterization of a novel cysteine proteinase (periodontain) from Porphyromonas gingivalis. Evidence for a role in the inactivation of human alpha1-proteinase inhibitor.
Periodontal Diseases
Relationship between periodontal disease status and combination of biochemical assays of gingival crevicular fluid.
Periodontal Diseases
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease.
Periodontal Diseases
[Granulocyte elastase activity and the content of acid-stable proteinase inhibitors in the oral fluid of patients with inflammatory periodontal diseases]
Periodontal Diseases
[Mutations of the ELANE gene cause severe congenital neutropenia with periodontal disease: a case report].
Periodontal Pocket
Granulocyte elastase activity and PGE2 levels in gingival crevicular fluid in relation to the presence of subgingival periodontopathogens in subjects with untreated adult periodontitis.
Periodontitis
Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin-dependent neutrophil lysis.
Periodontitis
Altered relation between granulocyte elastase and alpha-2-macroglobulin in gingival crevicular fluid from sites with periodontal destruction.
Periodontitis
Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis patients.
Periodontitis
Colorimetric Assay for the Detection of Typical Biomarkers for Periodontitis Using a Magnetic Nanoparticle Biosensor.
Periodontitis
Cross-sectional analysis of risk factors for subclinical periodontitis; active matrix metalloproteinase-8 as a potential indicator in initial periodontitis in adolescents.
Periodontitis
Elastase and alpha-1-proteinase inhibitor in gingival crevicular fluid and gingival tissue in adult and juvenile periodontitis.
Periodontitis
Elastin derived peptides protect elastic fibres degradation by human neutrophil elastase: in vitro and in vivo studies using a mechanically induced rat gingival inflammatory model.
Periodontitis
Granulocyte elastase in gingival crevicular fluid. A possible discriminator between gingivitis and periodontitis.
Periodontitis
Granulocyte elastase in gingival crevicular fluid: improved monitoring of the site-specific response to treatment in patients with destructive periodontitis.
Periodontitis
Granulocyte elastase, matrix metalloproteinase-8 and prostaglandin E2 in gingival crevicular fluid in matched clinical sites in smokers and non-smokers with persistent periodontitis.
Periodontitis
Influence of combinations of bacteria on the levels of prostaglandin E2, interleukin-1beta, and granulocyte elastase in gingival crevicular fluid and on the severity of periodontal disease.
Periodontitis
Inhibition of crevicular fluid neutrophil elastase by alpha 1-antitrypsin in periodontal health and disease.
Periodontitis
Interleukin-8 and granulocyte elastase in gingival crevicular fluid in relation to periodontopathogens in untreated adult periodontitis.
Periodontitis
Intracytoplasmic enzymes in gingival crevicular fluid of patients with aggressive periodontitis.
Periodontitis
Modification of cystatin C activity by bacterial proteinases and neutrophil elastase in periodontitis.
Periodontitis
Mutations in the ELANE Gene are Associated with Development of Periodontitis in Patients with Severe Congenital Neutropenia.
Periodontitis
Neutrophil elastase activity, levels of prostaglandin E2, and matrix metalloproteinase-8 in refractory periodontitis sites in smokers and non-smokers.
Periodontitis
Neutrophil elastase in crevicular fluid: comparison of a middle-aged general population with healthy and periodontitis groups.
Periodontitis
Oxidative stress, neutrophil elastase and IGFBP7 levels in patients with oropharyngeal cancer and chronic periodontitis.
Periodontitis
Proinflammatory cytokines production and PMN-elastase release from activated PMN cells in the periodontal disease.
Periodontitis
Regulation of Salivary Peptidoglycan Recognition Protein1in Adolescents.
Periodontitis
Salivary proteins associated with periodontitis in patients with type 2 diabetes mellitus.
Periodontitis
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease.
Periodontitis
The effects of non-surgical periodontal therapy on neutrophil elastase and elastase alpha-1 proteinase inhibitor levels in GCF in periodontitis patients with or without acute coronary syndrome.
Periodontitis
Variations in crevicular fluid elastase levels in periodontitis patients on long-term maintenance.
Periodontitis
[Evaluation of periodontitis treatment effectiveness based on indices of the activity of neutrophil elastase and its acid-stable inhibitor in the oral fluid of patients]
Periodontitis
[The treatment of periodontal diseases using Diplen-Denta films with chlorhexidine (a clinico-laboratory study)]
Peripheral Nervous System Diseases
Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice.
Peripheral Vascular Diseases
ZD-0892 AstraZeneca.
Peritonitis
A multicenter study of phospholipase A2 in patients in intensive care units.
Peritonitis
Diagnosis of spontaneous bacterial peritonitis in children using leukocyte esterase reagent strips and granulocyte elastase immunoassay.
Peritonitis
Granulocyte elastase in cirrhotic patients with spontaneous bacterial peritonitis.
Peritonitis
Molecular and functional aspects of alterations in the kallikrein-kinin system activity in human blood plasma at different stages of peritonitis and chronic renal failure.
Peritonitis
Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis.
Peritonitis
Perioperative pattern of peritoneal interleukin 8, tumour necrosis factor-alpha, and granulocyte elastase release in human secondary peritonitis.
Peritonitis
Rapid detection of spontaneous bacterial peritonitis by granulocyte elastase latex immunoassay and reagent strip.
Peritonitis
The Neutrophil Elastase Inhibitor Sivelestat Suppresses Accelerated Gastrointestinal Tumor Growth via Peritonitis After Cecal Ligation and Puncture.
Persistent Infection
Immunology of Pseudomonas aeruginosa infection in cystic fibrosis.
Persistent Infection
Kinetics of proteolysis of hog gastric mucin by human neutrophil elastase and by Pseudomonas aeruginosa elastase.
Plague
[Flow-cytofluorometric study of bactericidal granules in blood phagocytes of animals with various species sensitivity to experimental plague infection].
Pleural Effusion
Epithelial Neutrophil-Activating Peptide-78 Recruits Neutrophils into Pleural Effusion.
Pleural Effusion
Interleukin-8 and markers of neutrophil degranulation in pleural effusions.
Pleural Effusion
Neutrophil elastase alpha 1-proteinase inhibitor complexes in pleural effusions.
Pleural Effusion
ONO-5046 is a potent inhibitor of neutrophil elastase in human pleural effusion after lobectomy.
Pleural Effusion
Significance of microbiological and biochemical analyses in empyema thoracis.
Pleural Effusion
[Neutrophil elastase in postoperative pleural effusion of patients who had undergone pulmonary resections]
Pleurisy
[Determination of lactate and granulocyte elastase can be useful in the diagnosis of pleuritis]
Pneumonia
A specific neutrophil elastase inhibitor (ONO-5046.Na) attenuates LPS-induced acute lung inflammation in the hamster.
Pneumonia
Acute lung inflammation: neutrophil elastase versus neutrophils in the bronchoalveolar lavage--neutrophil elastase reflects better inflammatory intensity.
Pneumonia
Airway proteins involved in bacterial clearance susceptible to cathepsin G proteolysis.
Pneumonia
Alpha-1 antitrypsin reduces severity of pseudomonas pneumonia in mice and inhibits epithelial barrier disruption and pseudomonas invasion of respiratory epithelial cells.
Pneumonia
Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro.
Pneumonia
An alternative elastase-mediated degradation of fibrinogen and fibrin observed in a patient with herpes simplex encephalitis and pneumonia.
Pneumonia
Antimicrobial activity of antiproteinases.
Pneumonia
Association of plasma neutrophil elastase levels with other inflammatory mediators and clinical features in adult patients with moderate and severe pneumonia.
Pneumonia
Distribution of human neutrophil elastase in diffuse alveolar damage and pneumonia in a case of neonatal sepsis.
Pneumonia
Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia.
Pneumonia
Increased release of transforming growth factor (TGF)-beta1, TGF-beta2, and chemoattractant mediators in pneumonia.
Pneumonia
LTB4 is present in exudative pleural effusions and contributes actively to neutrophil recruitment in the inflamed pleural space.
Pneumonia
Magnetic Resonance Imaging of Protease-Mediated Lung Tissue Inflammation and Injury.
Pneumonia
Measurements of plasma elastase alpha 1-proteinase inhibitor complexes in patients receiving cancer chemotherapy with granulocyte colony-stimulating factor.
Pneumonia
Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis.
Pneumonia
Mutants of plasminogen activator inhibitor-1 designed to inhibit neutrophil elastase and cathepsin G are more effective in vivo than their endogenous inhibitors.
Pneumonia
Neutrophil elastase inhibitor reduces ventilation-induced lung injury via nuclear factor-?B and NF-?B repressing factor in mice.
Pneumonia
Neutrophil elastase inhibitor sivelestat ameliorates gefitinib-naphthalene-induced acute pneumonitis in mice.
Pneumonia
Neutrophil Elastase Modulates Cytokine Expression: Contribution to Host defense against Pseudomonas aeruginosa-induced Pneumonia.
Pneumonia
Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia.
Pneumonia
Neutrophil-mediated inflammation in respiratory syncytial viral bronchiolitis.
Pneumonia
Oxidative burst and neutrophil elastase contribute to clearance of Aspergillus fumigatus pneumonia in mice.
Pneumonia
Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide?induced pulmonary inflammation by inhibiting interleukin?8 production and NF??B activation.
Pneumonia
Plasma neutrophil elastase correlates with pulmonary vascular permeability: A prospective observational study in patients with pneumonia.
Pneumonia
Pulmonary matrix metalloproteinase-9 activity in mechanically ventilated children with respiratory syncytial virus.
Pneumonia
Regulation of hepatocyte growth factor in mice with pneumonia by peptidases and trans-alveolar flux.
Pneumonia
Secretory leukocyte proteinase inhibitor is a major leukocyte elastase inhibitor in human neutrophils.
Pneumonia
Silica particles enhance peripheral thrombosis: key role of lung macrophage-neutrophil cross-talk.
Pneumonia
Streptococcus pneumoniae disrupts pulmonary immune defence via elastase release following pneumolysin-dependent neutrophil lysis.
Pneumonia
Studies on the role of antileukoprotease in respiratory tract diseases.
Pneumonia
The clinical significance of oropharyngeal cultures in young children with cystic fibrosis.
Pneumonia
The methanol extract of Guettarda speciosa Linn. Ameliorates acute lung injury in mice.
Pneumonia
The Role of Neutrophil Elastase Inhibitors in Lung Diseases.
Pneumonia
[Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity]
Pneumonia
[Treatment of aspiration pneumonia with low-dose methylprednisolone and antibiotics]
Pneumonia, Bacterial
Beneficial effect of an inhibitor of leukocyte elastase (EPI-hNE-4) in presence of repeated lung injuries.
Pneumonia, Bacterial
In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia.
Pneumonia, Pneumococcal
Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia.
Pneumonia, Pneumococcal
Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia.
Pneumonia, Pneumococcal
Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia.
Pneumonia, Pneumococcal
The Role of Neutrophils and Neutrophil Elastase in Pneumococcal Pneumonia.
Pneumonia, Viral
Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia.
Polycystic Ovary Syndrome
Gingival Inflammation and Salivary or Serum Granulocyte Secreted Enzymes in Patients With Polycystic Ovary Syndrome.
Polymyalgia Rheumatica
Temporal arteritis in polymyalgia rheumatica: immune complex deposits and the role of the leukocyte elastase in the pathogenesis.
Polymyositis
Correlation of PMN elastase and PMN elastase-to-neutrophil ratio with disease activity in patients with myositis.
Pouchitis
Luminal neutrophil migration in ileoanal pouches studied by whole gut lavage.
Pre-Eclampsia
Complement, neutrophil, and macrophage activation in women with severe preeclampsia and the syndrome of hemolysis, elevated liver enzymes, and low platelet count.
Pre-Eclampsia
Correlation of Plasma Neutrophil Elastase Activity and Endogenous Protease Inhibitor Levels with the Severity of Pre-eclampsia.
Pre-Eclampsia
Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study.
Pre-Eclampsia
Pathological uterine perfusion in the second trimester is not associated with neutrophil activation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Reduced Neutrophil Elastase Activity and Neutrophil Extracellular Traps in Pediatric Acute Myeloid Leukemia May Increase the Rate of Infections.
Prehypertension
Elevated serum neutrophil elastase is related to prehypertension and airflow limitation in obese women.
Premature Birth
Neutrophil elastase in amniotic fluid as a predictor of preterm birth after emergent cervical cerclage.
Pressure Ulcer
Accelerated wound closure of pressure ulcers in aged mice by chitosan scaffolds with and without bFGF.
Primary Immunodeficiency Diseases
Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia.
Prostatitis
Evaluation of seminal plasma parameters in patients with chronic prostatitis or leukocytospermia.
Prostatitis
Granulocyte elastase levels do not correlate with anaerobic and aerobic bacterial growth in seminal plasma from infertile men.
Prostatitis
The evaluation of markers of prostatic inflammation and function of the prostate gland in patients with chronic prostatitis.
Prostatitis
The value of neutrophil elastase in diagnosis of type III prostatitis.
Prostatitis
[Content of neutrophil elastase in EPS and seminal plasma: A combined predictor in the diagnosis of type IIIA prostatitis with secondary infertility].
Proteinuria
Efficacy of AT in pre-eclampsia: a case-control prospective trial.
Proteinuria
Elastase deposits in the kidney and urinary elastase excretion in patients with glomerulonephritis - evidence for neutrophil involvement in renal injury.
Pseudomonas Infections
A secretory leukocyte protease inhibitor variant with improved activity against lung infection.
Pseudomonas Infections
Bronchiectasis in Infants and Preschool Children Diagnosed with Cystic Fibrosis after Newborn Screening.
Pseudomonas Infections
Polymorphonuclear leukocyte elastase: its effects on the pathogenesis of Pseudomonas aeruginosa infection in cystic fibrosis.
Pseudomonas Infections
Relevance between clinical status and exhaled molecules related to neutrophilic inflammation in pediatric cystic fibrosis.
Pseudomonas Infections
Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases.
Pseudoxanthoma Elasticum
Histomorphometric parameters and susceptibility to neutrophil elastase degradation of skin elastic fibres from healthy individuals and patients with Marfan syndrome, Ehlers-Danlos type IV, and pseudoxanthoma elasticum.
Psoriasis
Basement membrane zone as a target for human neutrophil elastase in psoriasis.
Psoriasis
Decreased specific anti-elastase activity in the uninvolved skin of patients with psoriasis.
Psoriasis
Differences in Staining for Neutrophil Elastase and its Controlling Inhibitor SLPI Reveal Heterogeneity among Neutrophils in Psoriasis.
Psoriasis
Evaluation of serine alpha 1-antitrypsin and polymorphonuclear leukocyte elastase contents and their immunogenetic correlation in psoriasis.
Psoriasis
Inhibition of Neutrophil Elastase and Cathepsin G As a New Approach to the Treatment of Psoriasis: From Fundamental Biology to Development of New Target-Specific Drugs.
Psoriasis
Neutrophil elastase promotes proliferation of HaCaT cell line and transwell psoriasis organ culture model.
Psoriasis
Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management.
Psoriasis
Phototriggered release of tetrapeptide AAPV from coumarinyl and pyrenyl cages.
Psoriasis
Plasma polymorphonuclear leukocyte elastase levels and its relation to disease activity in psoriasis.
Psoriasis
Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance.
Psoriasis
Topographic relation between skin-derived antileukoproteinase (SKALP) and leukocyte elastase in a case of annular pustular psoriasis.
Psoriasis
[Liberation of human leukocyte elastase by hypertonic saline baths in psoriasis]
Puerperal Infection
Possible prediction of neonatal and puerperal infections by intrapartum determination of polymorphonuclear granulocyte elastase levels in maternal blood.
Pulmonary Arterial Hypertension
Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model.
Pulmonary Arterial Hypertension
Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency.
Pulmonary Arterial Hypertension
The Role of Neutrophils and Neutrophil Elastase in Pulmonary Arterial Hypertension.
Pulmonary Aspergillosis
[Invasive pulmonary aspergillosis in a patient with acute leukemia--the role of neutrophil elastase in in cavity formation]
Pulmonary Disease, Chronic Obstructive
?-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
A mathematical model of protease-antiprotease homeostasis failure in chronic obstructive pulmonary disease (COPD).
Pulmonary Disease, Chronic Obstructive
A Randomised, Placebo-Controlled, Dose-Finding Study Of AZD9668, An Oral Inhibitor of Neutrophil Elastase, in Patients with Chronic Obstructive Pulmonary Disease Treated with Tiotropium.
Pulmonary Disease, Chronic Obstructive
A randomised, placebo-controlled, dose-finding study of AZD9668, an oral inhibitor of neutrophil elastase, in patients with chronic obstructive pulmonary disease treated with tiotropium.
Pulmonary Disease, Chronic Obstructive
A?-Val360: A Marker of Neutrophil Elastase and COPD Disease Activity.
Pulmonary Disease, Chronic Obstructive
Alpha-1 antitrypsin deficiency targeted testing and augmentation therapy: a Canadian Thoracic Society clinical practice guideline.
Pulmonary Disease, Chronic Obstructive
Alpha-1 antitrypsin therapy modulates the neutrophil membrane proteome and secretome.
Pulmonary Disease, Chronic Obstructive
Altered protease and antiprotease balance during a COPD exacerbation contributes to mucus obstruction.
Pulmonary Disease, Chronic Obstructive
An analysis of the organ and species immunospecificity of elastin.
Pulmonary Disease, Chronic Obstructive
Analysis of sputum markers in the evaluation of lung inflammation and functional impairment in symptomatic smokers and COPD patients.
Pulmonary Disease, Chronic Obstructive
Anti-inflammatory activity of neutrophil elastase inhibitors.
Pulmonary Disease, Chronic Obstructive
Atrial arrhythmogenesis in a rabbit model of chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
AZD9668, a neutrophil elastase inhibitor, plus ongoing budesonide/formoterol in patients with COPD.
Pulmonary Disease, Chronic Obstructive
AZD9668: pharmacological characterisation of a novel oral inhibitor of neutrophil elastase.
Pulmonary Disease, Chronic Obstructive
Biological markers in induced sputum of patients with different phenotypes of chronic airway obstruction.
Pulmonary Disease, Chronic Obstructive
Biomarkers in Alpha-1 Antitrypsin Deficiency Chronic Obstructive Pulmonary Disease.
Pulmonary Disease, Chronic Obstructive
Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD.
Pulmonary Disease, Chronic Obstructive
Budesonide mitigates pathological changes in animal model Of COPD through reducing neutrophil elastase expression.
Pulmonary Disease, Chronic Obstructive
Can hypertonic saline inhalation influence preformed chemokine and mediator release in induced sputum of chronic obstructive pulmonary disease patients? Comparison with isotonic saline.
Pulmonary Disease, Chronic Obstructive
Characterizing the Dynamics and Ligand-Specific Interactions in the Human Leukocyte Elastase through Molecular Dynamics Simulations.
Pulmonary Disease, Chronic Obstructive
Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity--a common inflammatory phenotype?
Pulmonary Disease, Chronic Obstructive
Clickable 4-Oxo-?-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes.
Pulmonary Disease, Chronic Obstructive
Clinical utility of alpha-1 proteinase inhibitor in the management of adult patients with severe alpha-1 antitrypsin deficiency: a review of the current literature.
Pulmonary Disease, Chronic Obstructive
Combined Inhibition of PDE4 and PI3K? Modulates the Inflammatory Component Involved in the Progression of Chronic Obstructive Pulmonary Disease.
Pulmonary Disease, Chronic Obstructive
Concomitant elevations of MMP-9, NGAL, proMMP-9/NGAL and neutrophil elastase in serum of smokers with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Decline in FEV(1) in community-based older volunteers with higher levels of neutrophil elastase in bronchoalveolar lavage fluid.
Pulmonary Disease, Chronic Obstructive
Delivery of Alpha-1 Antitrypsin to Airways.
Pulmonary Disease, Chronic Obstructive
DX-890 (Dyax).
Pulmonary Disease, Chronic Obstructive
Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency.
Pulmonary Disease, Chronic Obstructive
Effects of MR889, a cyclic thiolic neutrophil elastase inhibitor, on rheologic properties of mucus.
Pulmonary Disease, Chronic Obstructive
Electrophoretic mobility of leukocyte elastase of normal subjects and patients with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Elevated serum matrix metalloprotease (MMP-2) as a candidate biomarker for stable COPD.
Pulmonary Disease, Chronic Obstructive
Emerging drugs for the treatment of chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Expressions of MMP-12, TIMP-4, and Neutrophil Elastase in PBMCs and Exhaled Breath Condensate in Patients with COPD and Their Relationships with Disease Severity and Acute Exacerbations.
Pulmonary Disease, Chronic Obstructive
Feasibility of Computed Tomography in a Multicenter COPD Trial: A Study of the Effect of AZD9668 on Structural Airway Changes.
Pulmonary Disease, Chronic Obstructive
Genomics of Chronic Obstructive Pulmonary Disease (COPD); Exploring the SNPs of Protease-Antiprotease Pathway.
Pulmonary Disease, Chronic Obstructive
Glucocorticosteroids Differentially Regulate MMP-9 and Neutrophil Elastase in COPD.
Pulmonary Disease, Chronic Obstructive
Haplotypes of the alpha-1 antitrypsin gene in healthy controls and Z deficiency patients.
Pulmonary Disease, Chronic Obstructive
Hyaluronan blocks porcine pancreatic elastase-induced mucociliary dysfunction in allergic sheep.
Pulmonary Disease, Chronic Obstructive
Inflammatory mediators in exhaled breath condensate and peripheral blood of healthy donors and stable COPD patients.
Pulmonary Disease, Chronic Obstructive
Inhaled porcine pancreatic elastase causes bronchoconstriction via a bradykinin-mediated mechanism.
Pulmonary Disease, Chronic Obstructive
Interactions of neutrophil elastase, serum trypsin inhibitory activity, and smoking history as risk factors for chronic obstructive pulmonary disease in patients with MM, MZ, and ZZ phenotypes for alpha-antitrypsin.
Pulmonary Disease, Chronic Obstructive
Interactions of neutrophil elastase, serum trypsin inhibitory activity, and smoking history as risk factors for chronic obstructive pulmonary disease in patients with MM, MZ, and ZZ phenotypes for alpha1-antitrypsin.
Pulmonary Disease, Chronic Obstructive
Interrelationship between serum and sputum inflammatory mediators in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Interrelationships between neutrophil elastase, serum alpha, -antitrypsin, lung function and chest radiography in patients with chronic airflow obstruction.
Pulmonary Disease, Chronic Obstructive
l-Carbocisteine reduces neutrophil elastase-induced mucin production.
Pulmonary Disease, Chronic Obstructive
Matrine reduces cigarette smoke-induced airway neutrophilic inflammation by enhancing neutrophil apoptosis.
Pulmonary Disease, Chronic Obstructive
Measurement of C-reactive protein, procalcitonin and neutrophil elastase in saliva of COPD patients and healthy controls: correlation to self-reported wellbeing parameters.
Pulmonary Disease, Chronic Obstructive
MMP-12 activates protease-activated receptor-1, upregulates placenta growth factor, and leads to pulmonary emphysema.
Pulmonary Disease, Chronic Obstructive
MMP-8, MMP-9 and Neutrophil Elastase in Peripheral Blood and Exhaled Breath Condensate in COPD.
Pulmonary Disease, Chronic Obstructive
Molecular characterisation of the defective alpha 1-antitrypsin alleles PI Mwurzburg (Pro369Ser), Mheerlen (Pro369Leu), and Q0lisbon (Thr68Ile).
Pulmonary Disease, Chronic Obstructive
MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled clinical trial.
Pulmonary Disease, Chronic Obstructive
Neutrophil Elastase and Chronic Lung Disease.
Pulmonary Disease, Chronic Obstructive
Neutrophil elastase as a biomarker for bacterial infection in COPD.
Pulmonary Disease, Chronic Obstructive
Neutrophil Elastase as a Target in Lung Cancer.
Pulmonary Disease, Chronic Obstructive
Neutrophil Elastase Differentially Regulates Interleukin 8 (IL-8) and Vascular Endothelial Growth Factor (VEGF) Production by Cigarette Smoke Extract.
Pulmonary Disease, Chronic Obstructive
Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells.
Pulmonary Disease, Chronic Obstructive
Neutrophil elastase inhibitors as treatment for COPD.
Pulmonary Disease, Chronic Obstructive
Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores.
Pulmonary Disease, Chronic Obstructive
Neutrophil elastase inhibitors.
Pulmonary Disease, Chronic Obstructive
Neutrophil elastase inhibitors: recent advances in the development of mechanism-based and nonelectrophilic inhibitors.
Pulmonary Disease, Chronic Obstructive
Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway.
Pulmonary Disease, Chronic Obstructive
Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex.
Pulmonary Disease, Chronic Obstructive
Neutrophil lysosomal elastase activity in normal subjects and in patients with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Nicotine-stimulated elastase activity release by neutrophils in patients with abdominal aortic aneurysms.
Pulmonary Disease, Chronic Obstructive
ONO-6818 Cortech/Ono.
Pulmonary Disease, Chronic Obstructive
Pharmacokinetics and safety of AZD9668, an oral neutrophil elastase inhibitor, in healthy volunteers and patients with COPD.
Pulmonary Disease, Chronic Obstructive
PlGF mediates neutrophil elastase-induced airway epithelial cell apoptosis and emphysema.
Pulmonary Disease, Chronic Obstructive
Progranulin is a substrate for neutrophil-elastase and proteinase-3 in the airway and its concentration correlates with mediators of airway inflammation in COPD.
Pulmonary Disease, Chronic Obstructive
Proteases and antiproteases.
Pulmonary Disease, Chronic Obstructive
Proteinase/proteinase inhibitor imbalance in sputum sol phases from patients with chronic obstructive pulmonary disease. Suggestions for a key role played by antileukoprotease.
Pulmonary Disease, Chronic Obstructive
Quantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung.
Pulmonary Disease, Chronic Obstructive
Relationship between airway colonization, inflammation and exacerbation frequency in COPD.
Pulmonary Disease, Chronic Obstructive
Role of elastases in the pathogenesis of chronic obstructive pulmonary disease: implications for treatment.
Pulmonary Disease, Chronic Obstructive
Role of neutrophil elastase in hypersecretion during COPD exacerbations, and proposed therapies.
Pulmonary Disease, Chronic Obstructive
Role of Proteases in Chronic Obstructive Pulmonary Disease.
Pulmonary Disease, Chronic Obstructive
Selective Imaging of Lung Macrophages Using [11C]PBR28-Based Positron Emission Tomography.
Pulmonary Disease, Chronic Obstructive
SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer.
Pulmonary Disease, Chronic Obstructive
Serum amyloid A opposes lipoxin A? to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Severity of chronic obstructive pulmonary disease with 'exacerbator with emphysema phenotype' is associated with potential biomarkers.
Pulmonary Disease, Chronic Obstructive
Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase.
Pulmonary Disease, Chronic Obstructive
Targeting COPD: Advances on low-molecular-weight inhibitors of human neutrophil elastase.
Pulmonary Disease, Chronic Obstructive
The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro.
Pulmonary Disease, Chronic Obstructive
The fibrinogen cleavage product A{alpha}-Val360, a specific marker of neutrophil elastase activity in vivo.
Pulmonary Disease, Chronic Obstructive
The Relationship of the Fibrinogen Cleavage Biomarker A?-Val360 with Disease Severity and Activity in Alpha-1-antitrypsin Deficiency.
Pulmonary Disease, Chronic Obstructive
The Serpin Superfamily and Their Role in the Regulation and Dysfunction of Serine Protease Activity in COPD and Other Chronic Lung Diseases.
Pulmonary Disease, Chronic Obstructive
Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor.
Pulmonary Disease, Chronic Obstructive
Verification of zinc role in pathophysiology of chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
ZD-0892 AstraZeneca.
Pulmonary Disease, Chronic Obstructive
[Changes of neutrophil elastase in COPD and the role of elastase in experimental pulmonary hypertension]
Pulmonary Disease, Chronic Obstructive
[CLINICAL AND PATHOGENETIC PECULIARITIES OF DEVELOPMENT OF ENDOTHELIAL DYSFUNCTION].
Pulmonary Disease, Chronic Obstructive
[Proteases involved in airway inflammation of COPD]
Pulmonary Edema
Decreased lung hyaluronan in a model of ARDS in the rat: Effect of an inhibitor of leukocyte elastase.
Pulmonary Edema
Effect of a selective neutrophil elastase inhibitor on mortality and ventilator-free days in patients with increased extravascular lung water: a post hoc analysis of the PiCCO Pulmonary Edema Study.
Pulmonary Edema
Effect of a synthetic leukocyte elastase inhibitor on thrombin-induced pulmonary edema in the rat.
Pulmonary Edema
Prevention of Pulmonary Edema after Minimally Invasive Cardiac Surgery with Mini-Thoracotomy Using Neutrophil Elastase Inhibitor.
Pulmonary Edema
Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema.
Pulmonary Edema
[Pulmonary fibrosis after endotoxin-induced permeability edema]
Pulmonary Embolism
Changes in coagulation-fibrinolysis marker and neutrophil elastase following the use of tourniquet during total knee arthroplasty and the influence of neutrophil elastase on thromboembolism.
Pulmonary Embolism
Induction of pulmonary thromboembolism by neutrophil elastase in collagen-induced arthritis mice and effect of recombinant human soluble thrombomodulin.
Pulmonary Emphysema
5-Methyl-4H-3,1-benzoxazin-4-one derivatives: specific inhibitors of human leukocyte elastase.
Pulmonary Emphysema
A novel class of cyclic beta-dicarbonyl leaving groups and their use in the design of benzisothiazolone human leukocyte elastase inhibitors.
Pulmonary Emphysema
A novel oral neutrophil elastase inhibitor (ONO-6818) inhibits human neutrophil elastase-induced emphysema in rats.
Pulmonary Emphysema
A randomized clinical trial of alpha(1)-antitrypsin augmentation therapy.
Pulmonary Emphysema
Alpha,-antitrypsin and leukocyte elastase in infected and noninfected sputum.
Pulmonary Emphysema
Alpha-1 Antitrypsin Deficiency: Have We Got the Right Proteinase?
Pulmonary Emphysema
Biochemical and pharmacological activities of SR 26831, a potent and selective elastase inhibitor.
Pulmonary Emphysema
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Pulmonary Emphysema
Biomarkers in Alpha-1 Antitrypsin Deficiency Chronic Obstructive Pulmonary Disease.
Pulmonary Emphysema
Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase.
Pulmonary Emphysema
Characterisation of human lung elastin-derived peptides.
Pulmonary Emphysema
Chronic Obstructive Pulmonary Disease. A Biomarker and a Potential Therapy.
Pulmonary Emphysema
Direct interaction of ONO-5046 with human neutrophil elastase through ¹H NMR and molecular docking.
Pulmonary Emphysema
Evidence for in vivo internalization of human leukocyte elastase by alveolar macrophages.
Pulmonary Emphysema
Hypoxic injury to human alveolar macrophages accelerates release of previously bound neutrophil elastase. Implications for lung connective tissue injury including pulmonary emphysema.
Pulmonary Emphysema
Increased leukocyte elastase of the tracheal aspirate at birth and neonatal pulmonary emphysema.
Pulmonary Emphysema
Inhibition of elastase-induced acute inflammation and pulmonary emphysema in hamsters by a novel neutrophil elastase inhibitor FR901277.
Pulmonary Emphysema
Inhibition of human leukocyte elastase bound to elastin: relative ineffectiveness and two mechanisms of inhibitory activity.
Pulmonary Emphysema
Isolation and partial characterization of a proteinase with elastolytic activity from mouse blood leukocytes.
Pulmonary Emphysema
Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema.
Pulmonary Emphysema
Neutrophil elastase activity and superoxide production are diminished in neutrophils of alcoholics.
Pulmonary Emphysema
Neutrophil elastase cleaves VEGF to generate a VEGF fragment with altered activity.
Pulmonary Emphysema
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.
Pulmonary Emphysema
Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.
Pulmonary Emphysema
Orally bioavailable benzisothiazolone inhibitors of human leukocyte elastase.
Pulmonary Emphysema
Protection of rat lung from elastase-induced elastic fiber degradation in vitro and from emphysema in vivo by a trifluoroacetylpeptide anilide inhibitor.
Pulmonary Emphysema
Pulmonary deposition and disappearance of aerosolised secretory leucocyte protease inhibitor.
Pulmonary Emphysema
Search for drugs that may reduce the load of neutrophil azurophilic granule enzymes in the lungs of patients with emphysema.
Pulmonary Emphysema
Serine proteinase inhibitor therapy in alpha(1)-antitrypsin inhibitor deficiency and cystic fibrosis.
Pulmonary Emphysema
Structure, function, and control of neutrophil proteinases.
Pulmonary Emphysema
Synthesis in yeast of a functional oxidation-resistant mutant of human alpha-antitrypsin.
Pulmonary Emphysema
Synthetic elastase inhibitors: prospects for use in the treatment of emphysema.
Pulmonary Emphysema
The antielastase screen of the lower respiratory tract.
Pulmonary Emphysema
The beige mouse: role of neutrophil elastase in the development of pulmonary emphysema.
Pulmonary Emphysema
The elastase/alpha 1-proteinase inhibitor balance in the lung. A review.
Pulmonary Emphysema
The induction of pulmonary emphysema with human leukocyte elastase.
Pulmonary Emphysema
The role of free radicals and neutrophil elastase in development of pulmonary emphysema.
Pulmonary Emphysema
[Alpha 1-antiproteinase deficiency]
Pulmonary Emphysema
[Evaluation of desmosine excretion in urine and activity of elastase in neutrophils of patients with pulmonary emphysema]
Pulmonary Emphysema
[Neutrophil elastase and elastin-derived peptides in BAL fluid and emphysematous changes on CT scans]
Pulmonary Emphysema
[Problems in intensive care posed by imbalance in the protease--protease inhibitor system]
Pulmonary Fibrosis
A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice.
Pulmonary Fibrosis
Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice.
Pulmonary Fibrosis
Administration of truncated secretory leukoprotease inhibitor ameliorates bleomycin-induced pulmonary fibrosis in hamsters.
Pulmonary Fibrosis
Effects of elastase inhibitor on the epithelial cell apoptosis in bleomycin-induced pulmonary fibrosis.
Pulmonary Fibrosis
Effects of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice.
Pulmonary Fibrosis
Elevated Serum Concentrations of Polymorphonuclear Neutrophilic Leukocyte Elastase in Systemic Sclerosis: Association with Pulmonary Fibrosis.
Pulmonary Fibrosis
Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: association with pulmonary fibrosis.
Pulmonary Fibrosis
Granulocyte-macrophage colony-stimulating factor primes interleukin-13 production by macrophages via protease-activated receptor-2.
Pulmonary Fibrosis
Inhibition of Leukocyte Elastase, Polymorphonuclear Chemoinvasion, and Inflammation-Triggered Pulmonary Fibrosis by a 4-Alkyliden-beta-lactam with a Galloyl Moiety.
Pulmonary Fibrosis
Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis.
Pulmonary Fibrosis
Neutrophil elastase-releasing factors in bronchoalveolar lavage from patients with adult respiratory distress syndrome.
Pulmonary Fibrosis
Neutrophil elastase: alpha-1-proteinase inhibitor complex in serum and bronchoalveolar lavage fluid in patients with pulmonary fibrosis.
Pulmonary Fibrosis
ONO-5046 (Ono Pharmaceutical).
Pulmonary Fibrosis
Particulate Matter Increases the Severity of Bleomycin-Induced Pulmonary Fibrosis through KC-Mediated Neutrophil Chemotaxis.
Pulmonary Fibrosis
[Strategy of therapy for interstitial lung disease due to chemotherapeutic drugs or radiation]
Purpura
Neutrophil extracellular traps as a potential source of autoantigen in cocaine-associated autoimmunity.
Purpura, Thrombotic Thrombocytopenic
Elevated plasma neutrophil elastase concentration is associated with disease activity in patients with thrombotic thrombocytopenic purpura.
Pyelonephritis
The possible role of granulocyte elastase in renal damage from acute pyelonephritis.
Renal Insufficiency
Elastase and exacerbation of neutrophil innate immunity are involved in multi-visceral manifestations of COVID-19.
Renal Insufficiency, Chronic
Neutrophil Elastase Inhibitors and Chronic Kidney Disease.
Renal Insufficiency, Chronic
Polymorphisms of the ELANE Gene Promoter Region in End-Stage Chronic Kidney Disease Patients.
Reperfusion Injury
A neutrophil elastase inhibitor improves lung function during ex vivo lung perfusion.
Reperfusion Injury
Activation of intracellular neutrophil elastase in the transplantation of ischemic liver.
Reperfusion Injury
Addition of a neutrophil elastase inhibitor to the organ flushing solution decreases lung reperfusion injury in rat lung transplantation.
Reperfusion Injury
Benefical effect of neutrophil elastase inhibitor on renal warm ischemia-reperfusion injury in the rat.
Reperfusion Injury
Early cellular brain damage and systemic inflammatory response after cardiopulmonary resuscitation or isolated severe head trauma: a comparative pilot study on common pathomechanisms.
Reperfusion Injury
Effects of a specific neutrophil elastase inhibitor (ONO-5046 Na) and neutrophil depletion using a G-1 column on lung reperfusion injury in dogs.
Reperfusion Injury
Effects of neutrophil elastase inhibitor on reperfusion injury in the canine liver.
Reperfusion Injury
Microvascular permeability of the non-heart-beating rabbit lung after warm ischemia and reperfusion: role of neutrophil elastase.
Reperfusion Injury
Neutrophil elastase activity in hepatic ischemia reperfusion injury.
Reperfusion Injury
Neutrophil elastase enhances intercellular adhesion molecule-1 expression.
Reperfusion Injury
Neutrophil elastase inhibitor (ONO-5046) attenuates reperfusion-induced hepatic microcirculatory derangement, energy depletion and lipid peroxidation in rats.
Reperfusion Injury
Neutrophil elastase inhibitor (ONO-5046) decreases cytokine-induced neutrophil chemoattractant after reperfusion of pancreaticoduodenal transplantation in rats.
Reperfusion Injury
Neutrophil elastase inhibitor ameliorates reperfusion injury in a canine model of lung transplantation.
Reperfusion Injury
Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats.
Reperfusion Injury
Neutrophil elastase inhibitor is a potent therapeutic agent to control renal ischemia-reperfusion injury.
Reperfusion Injury
Neutrophil elastase inhibitor reduces neutrophil chemoattractant production after ischemia-reperfusion in rat liver.
Reperfusion Injury
Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder.
Reperfusion Injury
Neutrophil elastase: a determinant of endothelial damage and reperfusion injury after liver transplantation?
Reperfusion Injury
Protective effect of Sivelestat in a porcine hepatectomy model prepared using an intermittent Pringle method.
Reperfusion Injury
Role of neutrophil depletion and elastase inhibition in modifying skeletal muscle reperfusion injury.
Reperfusion Injury
Sivelestat reduces reperfusion injury of lungs harvested from endotoxin-primed rats by inhibition of neutrophil-mediated inflammation.
Reperfusion Injury
Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury.
Reperfusion Injury
Sivelestat, a neutrophil elastase inhibitor, attenuates neutrophil priming after hepatoenteric ischemia in rabbits.
Reperfusion Injury
The effect of neutrophil elastase inhibitor in hepatectomy with ischemia in dogs.
Reperfusion Injury
The effect of neutrophil elastase inhibitor on acute tubular necrosis after renal ischemia-reperfusion injury.
Reperfusion Injury
The effects of a neutrophil elastase inhibitor (ONO-5046.Na) and neutrophil depletion using a granulotrap (G-1) column on lung reperfusion injury in dogs.
Reperfusion Injury
The effects of a specific neutrophil elastase inhibitor (ONO-5046) in pulmonary ischemia-reperfusion injury.
Reproductive Tract Infections
[Significance of neutrophil elastase in diagnosis of male genital tract infection]
Respiratory Distress Syndrome
5-Methyl-4H-3,1-benzoxazin-4-one derivatives: specific inhibitors of human leukocyte elastase.
Respiratory Distress Syndrome
A neutrophil elastase inhibitor improves lung function during ex vivo lung perfusion.
Respiratory Distress Syndrome
Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice.
Respiratory Distress Syndrome
Alveolar fluid neutrophil elastase activity in the adult respiratory distress syndrome is complexed to alpha-2-macroglobulin.
Respiratory Distress Syndrome
Anti-inflammatory activity of neutrophil elastase inhibitors.
Respiratory Distress Syndrome
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Respiratory Distress Syndrome
Clinical effects of a neutrophil elastase inhibitor, sivelestat, in patients with acute respiratory distress syndrome.
Respiratory Distress Syndrome
Clinical utility of the neutrophil elastase inhibitor sivelestat for the treatment of acute respiratory distress syndrome.
Respiratory Distress Syndrome
Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients.
Respiratory Distress Syndrome
Direct interaction of ONO-5046 with human neutrophil elastase through ¹H NMR and molecular docking.
Respiratory Distress Syndrome
Effect of a selective neutrophil elastase inhibitor on mortality and ventilator-free days in patients with increased extravascular lung water: a post hoc analysis of the PiCCO Pulmonary Edema Study.
Respiratory Distress Syndrome
Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis.
Respiratory Distress Syndrome
Efficacy of early sivelestat administration on acute lung injury and acute respiratory distress syndrome.
Respiratory Distress Syndrome
Elevation of pivaloylcarnitine by sivelestat sodium in two children.
Respiratory Distress Syndrome
Evaluation of appropriate indications for the use of sivelestat sodium in acute respiratory distress syndrome: a retrospective cohort study.
Respiratory Distress Syndrome
Imbalances between the levels of tissue factor and tissue factor pathway inhibitor in ARDS patients.
Respiratory Distress Syndrome
Increased neutrophil elastase, persistent intravascular coagulation, and decreased fibrinolytic activity in patients with posttraumatic acute respiratory distress syndrome.
Respiratory Distress Syndrome
Inhaled porcine pancreatic elastase causes bronchoconstriction via a bradykinin-mediated mechanism.
Respiratory Distress Syndrome
Interleukin 8 and granulocyte elastase alpha 1 proteinase inhibitor complex in the tracheobronchial aspirate of infants with chronic lung disease following respiratory distress syndrome.
Respiratory Distress Syndrome
Interleukin 8 and granulocyte elastase in the tracheobronchial aspirate of infants without respiratory distress syndrome or intrauterine infection and development of chronic lung disease.
Respiratory Distress Syndrome
Interleukin 8-related neutrophil elastase and the severity of the adult respiratory distress syndrome.
Respiratory Distress Syndrome
Neutrophil elastase activity in acute lung injury and respiratory distress syndrome.
Respiratory Distress Syndrome
Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics.
Respiratory Distress Syndrome
Neutrophil elastase and acute pulmonary damage in neonates with severe respiratory distress syndrome.
Respiratory Distress Syndrome
Neutrophil elastase as a predicting factor for development of acute lung injury.
Respiratory Distress Syndrome
Neutrophil Elastase Damages the Pulmonary Endothelial Glycocalyx in Lipopolysaccharide-Induced Experimental Endotoxemia.
Respiratory Distress Syndrome
Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
Respiratory Distress Syndrome
Neutrophil elastase inhibitors, SC-37698 and SC-39026, reduce endotoxin-induced lung dysfunction in awake sheep.
Respiratory Distress Syndrome
Pilot study of the effects of ONO-5046 in patients with acute respiratory distress syndrome.
Respiratory Distress Syndrome
Plasma interleukin 8 and polymorphonuclear leukocyte elastase concentrations in patients with septic shock.
Respiratory Distress Syndrome
Plasma Neutrophil Elastase and Elafin as Prognostic Biomarker for Acute Respiratory Distress Syndrome: A Multicenter Survival and Longitudinal Prospective Observation Study.
Respiratory Distress Syndrome
Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development.
Respiratory Distress Syndrome
Relationship between alpha-tocopherol and polymorphonuclear leukocyte elastase in septic adult respiratory distress syndrome.
Respiratory Distress Syndrome
Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice.
Respiratory Distress Syndrome
Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both ARDS and DIC patients.
Respiratory Distress Syndrome
Successful management of postoperative acute respiratory distress syndrome in a patient with lung cancer.
Respiratory Distress Syndrome
Synthesis and evaluation of benzenesulfonic acid derivatives as human neutrophil elastase (hNE) inhibitors.
Respiratory Distress Syndrome
The potential efficacy of noninvasive ventilation with administration of a neutrophil elastase inhibitor for acute respiratory distress syndrome.
Respiratory Distress Syndrome
The presence of neutrophil elastase and evidence of oxidation activity in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome.
Respiratory Distress Syndrome
Usefulness of a selective neutrophil elastase inhibitor (sivelestat) in septic ARDS patients after gastrointestinal surgery.
Respiratory Distress Syndrome
[Dynamic changes in polymorphonuclear cell elastase-alpha 1 protease inhibitor complex, a stress marker, in various pulmonary diseases]
Respiratory Distress Syndrome
[Experimental research on the pathogenic mechanisms in adult respiratory distress syndrome]
Respiratory Distress Syndrome
[Prognostic significance of neutrophil elastase inhibitor in patients with acute lung injury and interstitial pneumonia]
Respiratory Distress Syndrome
[Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity]
Respiratory Distress Syndrome
[The role of neutrophil elastase and its inhibitors in acute respiratory distress syndrome: an update].
Respiratory Insufficiency
Design and synthesis of peptide-based carboxylic acid-containing transition-state inhibitors of human neutrophil elastase.
Respiratory Insufficiency
Diagnostic criteria for adult respiratory distress syndrome: time for reappraisal.
Respiratory Insufficiency
Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters.
Respiratory Insufficiency
Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia.
Respiratory Insufficiency
The effect of sivelestat sodium hydrate on severe respiratory failure after thoracic aortic surgery with deep hypothermia.
Respiratory Insufficiency
The effects of a neutrophil elastase inhibitor on the postoperative respiratory failure of acute aortic dissection.
Respiratory Insufficiency
[ARDS-like reactive respiratory failure after radical operation for esophageal cancer--with reference to PMN elastase and anaphylatoxin]
Respiratory Insufficiency
[Changes in polymorphonuclear leukocyte elastase (PMNE) during shock; the effect of PMNE on respiratory failure]
Respiratory Insufficiency
[Dynamic changes in polymorphonuclear cell elastase-alpha 1 protease inhibitor complex, a stress marker, in various pulmonary diseases]
Respiratory Insufficiency
[Effects of ulinastatin on plasma polymorphonuclear leukocyte elastase activity and respiratory function in patients undergoing cardiopulmonary bypass]
Respiratory Tract Infections
Clinical and immunoregulatory effects of roxithromycin therapy for chronic respiratory tract infection.
Respiratory Tract Infections
Role of inflammation in respiratory tract infections.
Rheumatic Diseases
Competitive neutrophil elastase inhibitory isoflavones from the roots of Flemingia philippinensis.
Rheumatic Diseases
Frankincense--therapeutic properties.
Rhinitis
Reduction of TLR2 gene expression in allergic and nonallergic rhinitis.
Rhinitis, Allergic
Activity of leukocyte elastase in patients' plasma is a significant indicator of atopic diseases.
Rhinitis, Allergic
Nasal response to capsaicin in patients with allergic rhinitis and in healthy volunteers: effect of colchicine.
Rhinitis, Allergic
Secretory leukocyte protease inhibitor in normal, allergic and virus induced nasal secretions.
Rhinitis, Allergic
The effect of immediate-hypersensitivity reactions on the level of SLPI, granulocyte elastase, alpha1-antitrypsin, and albumin in nasal secretions, by the method of unilateral antigen challenge.
Sarcoidosis
Lung lavage neutrophils, neutrophil elastase and albumin in the prognosis of pulmonary sarcoidosis.
Sarcoidosis
Neutrophil elastase-releasing factors in bronchoalveolar lavage from patients with adult respiratory distress syndrome.
Sarcoidosis
Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders.
Sarcoidosis
Prognostic value of plasma neutrophil elastase levels in pulmonary sarcoidosis.
Sarcoidosis
[Characterization of structural and cellular components in pulmonary sarcoidosis granuloma]
Sarcoidosis, Pulmonary
Lung lavage neutrophils, neutrophil elastase and albumin in the prognosis of pulmonary sarcoidosis.
Sarcoidosis, Pulmonary
Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders.
Sarcoidosis, Pulmonary
Prognostic value of plasma neutrophil elastase levels in pulmonary sarcoidosis.
Scleroderma, Systemic
A potential contribution of trappin-2 to the development of vasculopathy in systemic sclerosis.
Scleroderma, Systemic
Elevated Serum Concentrations of Polymorphonuclear Neutrophilic Leukocyte Elastase in Systemic Sclerosis: Association with Pulmonary Fibrosis.
Scleroderma, Systemic
Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: association with pulmonary fibrosis.
Scrub Typhus
Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos.
Seizures
Convulsions in hemodialysis (HD) patients with elevated polymorphonuclear leukocyte elastase (PMNE) levels.
Sepsis
A low TAFI activity and insufficient activation of fibrinolysis by both plasmin and neutrophil elastase promote organ dysfunction in disseminated intravascular coagulation associated with sepsis.
Sepsis
Complement activation and polymorphonuclear neutrophil leukocyte elastase in sepsis. Correlation with severity of disease.
Sepsis
Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation.
Sepsis
Discrepancy between latex and ELISA D-dimer values in sepsis may be caused by human neutrophil elastase.
Sepsis
Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6.
Sepsis
Granulocyte elastase and white cell counts in septic pigs.
Sepsis
Granulocyte elastase compared to C-reactive protein for early diagnosis of septicemia in critically ill patients.
Sepsis
High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis.
Sepsis
Identification of Potential Biomarkers and Immune Features of Sepsis Using Bioinformatics Analysis.
Sepsis
Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia.
Sepsis
Imbalances between the levels of tissue factor and tissue factor pathway inhibitor in ARDS patients.
Sepsis
Inhibition of Efferocytosis by Extracellular CIRP-Induced Neutrophil Extracellular Traps.
Sepsis
Leukocyte function assessed via serial microlitre sampling of peripheral blood from sepsis patients correlates with disease severity.
Sepsis
Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis.
Sepsis
MiR-608 Exerts Anti-inflammatory Effects by Targeting ELANE in Monocytes.
Sepsis
Monoclonal antibody to tumor necrosis factor--alpha prevents lethal endotoxin sepsis in adult rhesus monkeys.
Sepsis
Neutrophil Elastase Inhibition Ameliorates Endotoxin-Induced Myocardial Injury Accompanying Degradation of Cardiac Capillary Glycocalyx.
Sepsis
Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
Sepsis
Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.
Sepsis
Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis.
Sepsis
Neutrophil extracellular traps in the host defense against sepsis induced by Burkholderia pseudomallei (melioidosis).
Sepsis
Parameters influencing membrane CD14 expression and soluble CD14 levels in sepsis.
Sepsis
Phospholipase A in acute lung injury after trauma and sepsis: its relation to the inflammatory mediators PMN-elastase, C3a, and neopterin.
Sepsis
Plasmapheresis in Sepsis-induced Thrombotic Microangiopathy: A Case Series.
Sepsis
PMN elastase in bone and joint infections.
Sepsis
Proteinases in catabolism and malnutrition.
Sepsis
Released granulocytic elastase: an indicator of pathobiochemical alterations in septicemia after abdominal surgery.
Sepsis
Role of granulocyte elastase in tissue injury in patients with septic shock complicated by multiple-organ failure.
Sepsis
Serial changes in neutrophil-endothelial activation markers during the course of sepsis associated with disseminated intravascular coagulation.
Sepsis
Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both ARDS and DIC patients.
Sepsis
Syndecan-4-dependent signaling in the inhibition of endotoxin-induced endothelial adherence of neutrophils by antithrombin.
Sepsis
The activation of neutrophil elastase-mediated fibrinolysis is not sufficient to overcome the fibrinolytic shutdown of disseminated intravascular coagulation associated with systemic inflammation.
Sepsis
The inactivation of human plasma alpha 1-proteinase inhibitor by proteinases from Staphylococcus aureus.
Sepsis
The Proteolytic Inactivation of Protein Z-Dependent Protease Inhibitor by Neutrophil Elastase Might Promote the Procoagulant Activity of Neutrophil Extracellular Traps in Sepsis.
Sepsis
The role of bacterial lipopolysaccharide-bound neutrophils in the pathogenesis of Kawasaki disease.
Sepsis
The role of inflammatory cells and their proteases in extravascular fibrinolysis.
Sepsis
Time Series Gene Expression Profiles Analysis Identified Several Potential Biomarkers for Sepsis.
Sepsis
Tissue factor production not balanced by tissue factor pathway inhibitor in sepsis promotes poor prognosis.
Sepsis
Transcriptome Meta-Analysis Deciphers a Dysregulation in Immune Response-Associated Gene Signatures during Sepsis.
Sepsis
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
Sepsis
[Advancement in the diagnosis of disseminated intravascular coagulation for the surgeon]
Sepsis
[Current findings in the pathogenesis of the shock process in traumatology]
Sepsis
[Cytokine storm in the pathogenesis of multiple organ dysfunction syndrome associated with surgical insults]
Sepsis
[PMN-elastase as a marker in diagnosis and follow-up of bone and joint infections]
Sepsis
[Polymorphonuclear leukocyte elastase (PMNE) levels in sepsis; the effect of PMNE on multiple organ failure (MOF)]
Sepsis
[Reduction in leukocyte elastase levels in patients with sepsis by administration of urinastatin]
Sepsis
[Screening and identification of potential targets of carthamin against sepsis].
Sepsis
[Understanding the pathogenetic mechanisms of SIRS and sepsis and development of innovative therapies of sepsis]
Severe Acute Respiratory Syndrome
A possible pathogenic correlation between neutrophil elastase (NE) enzyme and inflammation in the pathogenesis of coronavirus disease 2019 (COVID-19).
Severe Combined Immunodeficiency
Neutrophil elastase inhibitor (ONO-5046-Na) inhibits the growth of human lung cancer cell lines transplanted into severe combined immunodeficiency (scid) mice.
Sexually Transmitted Diseases
Clinical relevance of polymorphonuclear (PMN-) elastase determination in semen and serum during infertility investigation.
Shock, Cardiogenic
Granulocyte elastase in acute myocardial infarction.
Shock, Septic
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Shock, Septic
Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model.
Shock, Septic
Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock.
Shock, Septic
Expression of endothelial leukocyte adhesion molecule-1 in septic but not traumatic/hypovolemic shock in the baboon.
Shock, Septic
Neutrophil elastase, thrombin and plasmin in septic shock.
Shock, Septic
Plasma interleukin 8 and polymorphonuclear leukocyte elastase concentrations in patients with septic shock.
Shock, Septic
Recombinant C1 inhibitor P5/P3 variants display resistance to catalytic inactivation by stimulated neutrophils.
Shock, Septic
Release of granulocyte elastase in lethal canine endotoxin shock.
Shock, Septic
Role of granulocyte elastase in tissue injury in patients with septic shock complicated by multiple-organ failure.
Shock, Septic
Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats.
Shock, Septic
The disturbance of hemostasis in septic shock: role of neutrophil elastase and thrombin, effects of antithrombin III and plasma substitution.
Shock, Septic
The role of inflammatory cells and their proteases in extravascular fibrinolysis.
Shock, Septic
Therapeutic effects of the combination of two proteinase inhibitors in endotoxin shock of the pig.
Shock, Septic
Tissue factor production not balanced by tissue factor pathway inhibitor in sepsis promotes poor prognosis.
Shwachman-Diamond Syndrome
Current insights into inherited bone marrow failure syndromes.
Silicosis
Special neutrophil elastase inhibitory activity in BAL fluid from patients with silicosis and asbestosis.
Sinusitis
Allergic fungal sinusitis: an immunohistologic analysis.
Sinusitis
ELISA for determination of immunoreactive free elastase and elastase in complex with alpha 1-antitrypsin in nasal secretions with sinusitis.
Sinusitis
Neutrophil elastase and its complex with alpha 1-antitrypsin in soluble and insoluble fractions of nasal secretions of chronic sinusitis.
Skin Diseases
A comparative study of expression of Fc receptors in relation to the autoantibody-mediated immune response and neutrophil elastase expression in autoimmune blistering dermatoses.
Skin Diseases
Immunoexpression of IgA receptors (CD89, CD71) in dermatitis herpetiformis.
Skin Diseases
Ultrastructural changes of the skin induced by human leukocyte elastase and cathepsin G.
Spinal Cord Injuries
A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats.
Spinal Cord Injuries
MiR-325-3p promotes locomotor function recovery in rats with spinal cord injury via inhibiting the expression of neutrophil elastase.
Spinal Cord Injuries
Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury.
Spinal Cord Injuries
Neutrophil elastase mediates acute pathogenesis and is a determinant of long-term behavioral recovery after traumatic injury to the immature brain.
Spinal Cord Injuries
Role of neutrophil elastase in compression-induced spinal cord injury in rats.
Spondylarthropathies
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Spondylitis, Ankylosing
Circulating inhibitor bound elastase in patients with ankylosing spondylitis and rheumatoid arthritis and the influence of sulphasalazine treatment.
Squamous Cell Carcinoma of Head and Neck
Assessment of Cytokine Release against Oral Mucosal Cell Line Culture (TR146) Stimulated by Neutrophil Elastase Associated with Behcet's Disease.
ST Elevation Myocardial Infarction
Culprit site extracellular DNA and microvascular obstruction in ST-elevation myocardial infarction.
Starvation
Proteomic analysis of rainbow trout (Oncorhynchus mykiss) intestinal epithelia: physiological acclimation to short-term starvation.
Stroke
Increase in jugular levels of polymorphonuclear neutrophil elastase in patients with acute cerebral infarction.
Stroke
Neutrophil elastase and neurovascular injury following focal stroke and reperfusion.
Stroke
Polymorphonuclear leukocyte elastase in patients with stroke.
Stroke
Risk of Thrombus Fragmentation during Endovascular Stroke Treatment.
Superinfection
The inflammasome potentiates influenza/Staphylococcus aureus superinfection in mice.
Sweet Syndrome
[Acute febrile neutrophilic dermatosis (Sweet syndrome). Case report and immunohistologic study of neutrophil-associated proteolytic enzymes and their inhibitors]
Synovitis
Measurement of plasma concentrations of polymorphonuclear elastase-alpha 1 proteinase inhibitor (elastase-alpha 1 antitrypsin) in patients with rheumatoid arthritis: interference by rheumatoid factor.
Syphilis
[Leukocyte elastase, alpha 1-proteinase inhibitor and C-reactive protein in patients with delayed negativation of serological reactions after treatment of early syphilis].
Thrombocytopenia
A novel ELANE gene mutation in a patient with severe congenital neutropenia and intermittent thrombocytopenia.
Thrombocytopenia
Application of argatroban, direct thrombin inhibitor, in heparin-intolerant patients requiring extracorporeal circulation.
Thrombocytopenia
Enzyme-Agnostic Lysosomal Screen Identifies New Legumain-Cleavable ADC Linkers.
Thrombocytopenia
The relation between fibrinogen level, neutrophil activity and nucleosomes in the onset of disseminated intravascular coagulation in the critically ill.
Thromboembolism
Changes in coagulation-fibrinolysis marker and neutrophil elastase following the use of tourniquet during total knee arthroplasty and the influence of neutrophil elastase on thromboembolism.
Thromboinflammation
Biological basis and pathological relevance of microvascular thrombosis.
Thrombophilia
[Regional biochemical and hematologic changes in patients after revascularization of the lower extremities in ischemia of the extremities]
Thrombosis
Association of calprotectin with other inflammatory parameters in the prediction of mortality for ischemic stroke.
Thrombosis
DNAse-dependent, NET-independent pathway of thrombus formation in vivo.
Thrombosis
Leukocyte elastase inhibition and t-PA-induced coronary artery thrombolysis in dogs: beneficial effects on myocardial histology.
Thrombosis
Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy.
Thrombosis
Neutrophil chemotaxis and neutrophil elastase in the aortic wall in patients with abdominal aortic aneurysms.
Thrombosis
Plakalbumin, alpha 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis.
Thrombosis
Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases.
Thrombosis
Risk of Thrombus Fragmentation during Endovascular Stroke Treatment.
Thrombosis
Role of leucocytes in coagulation induced by artificial surfaces: investigation of expression of Mac-1, granulocyte elastase release and leucocyte adhesion on modified polyurethanes.
Thrombosis
Role of leukocyte elastase in preventing cellular re-colonization of the mural thrombus.
Tooth Mobility
[Mutations of the ELANE gene cause severe congenital neutropenia with periodontal disease: a case report].
Tuberculosis
LTB4 is present in exudative pleural effusions and contributes actively to neutrophil recruitment in the inflamed pleural space.
Tuberculosis
Screening of potential biomarkers for distinguishing between latent and active tuberculosis in children using bioinformatics analysis.
Tuberculosis
Severe congenital neutropenia caused by the ELANE gene mutation in a Vietnamese boy with misdiagnosis of tuberculosis and autoimmune neutropenia: a case report.
Tuberculosis
[Leukocyte elastase in blood plasma from tuberculosis patients and its role in disturbances of blood coagulation regulatory processes]
Tuberculosis, Pleural
PARTICULAR QUALITIES OF THE PROTEOLYTIC SYSTEM IN PATIENTS WITH TUBERCULOSIS DEPENDING ON THE SENSITIVITY OF THE PATHOGEN.
Tuberculosis, Pulmonary
Neutrophil extracellular traps in patients with pulmonary tuberculosis.
Tuberculosis, Pulmonary
PARTICULAR QUALITIES OF THE PROTEOLYTIC SYSTEM IN PATIENTS WITH TUBERCULOSIS DEPENDING ON THE SENSITIVITY OF THE PATHOGEN.
Tuberculosis, Pulmonary
[Serum neutrophil elastase and activity of its inhibitors in patients with pulmonary tuberculosis]
Typhus, Endemic Flea-Borne
Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos.
Urethritis
Complement C3, coeruloplasmin and PMN-elastase in the ejaculate in chronic prostato-adnexitis and their diagnostic value.
Urethritis
Neutrophil enzymes in urine for the detection of urethral infection in men.
Urinary Bladder Neoplasms
Correlation of Immune Cells and Cytokines in the Tumor Microenvironment with Elevated Neutrophil-To-Lymphocyte Ratio in Blood: An Analysis of Muscle-Invasive Bladder Cancer.
Urinary Incontinence
The role of neutrophil elastase in elastin metabolism of pelvic tissues from women with stress urinary incontinence.
Urinary Tract Infections
A kinetic study of the hydrolysis of the N-tosylalanine ester of 3-hydroxy-5-phenylpyrrole and related compounds by human leukocyte elastase.
Uterine Prolapse
Gene expression and immunoreactivity of elastolytic enzymes in the uterosacral ligaments from women with uterine prolapse.
Varicose Ulcer
Prognostic value of markers of collagen remodeling in venous ulcers.
Vascular Diseases
Leucocyte mobilization and release of neutrophil elastase following acute insulin-induced hypoglycaemia in normal humans.
Vascular Diseases
Neutrophil activation detected by increased neutrophil elastase activity in type 1 (insulin-dependent) diabetes mellitus.
Vascular Diseases
Neutrophil elastase promotes neointimal hyperplasia by targeting toll-like receptor 4 (TLR4)-NF-?B signalling.
Vascular Diseases
Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders.
Vascular System Injuries
Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats.
Vascular System Injuries
Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection.
Vascular System Injuries
Endotoxin-induced pulmonary vascular injury is mainly mediated by activated neutrophils in rats.
Vascular System Injuries
FMLP causes eicosanoid-dependent vasoconstriction and edema in lungs from endotoxin-primed rats.
Vascular System Injuries
Recombinant human soluble thrombomodulin reduces endotoxin-induced pulmonary vascular injury via protein C activation in rats.
Vascular System Injuries
Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats.
Vascular System Injuries
Role of the endogenous elastase inhibitor, elafin, in cardiovascular injury: from epithelium to endothelium.
Vasculitis
Antibodies to neutrophil elastase: a study in patients with vasculitis.
Vasculitis
Antineutrophil cytoplasmic antibodies reacting with human neutrophil elastase as a diagnostic marker for cocaine-induced midline destructive lesions but not autoimmune vasculitis.
Vasculitis
Cocaine-related retiform purpura: evidence to incriminate the adulterant, levamisole.
Vasculitis
Cutaneous vasculitis in breast cancer treated with chemotherapy.
Vasculitis
How to spot cocaine-induced pseudovasculitis.
Vasculitis
Molecular characteristics of anti-self antibody fragments against neutrophil cytoplasmic antigens from human V gene phage display libraries.
Vasculitis
Role of neutrophil elastase in the development of renal necrotizing vasculitis.
Vasculitis
Structure of the azurocidin, proteinase 3, and neutrophil elastase genes. Implications for inflammation and vasculitis.
Vasculitis
Structures of human proteinase 3 and neutrophil elastase--so similar yet so different.
Vasculitis
Suppression of Neutrophil-Mediated Tissue Damage-A Novel Skill of Mesenchymal Stem Cells.
Vasculitis
The role of inflammatory cells and their proteases in extravascular fibrinolysis.
Vasculitis
Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy.
Venous Thrombosis
Changes in coagulation-fibrinolysis marker and neutrophil elastase following the use of tourniquet during total knee arthroplasty and the influence of neutrophil elastase on thromboembolism.
Ventilator-Induced Lung Injury
Effect of a neutrophil elastase inhibitor on ventilator-induced lung injury in rats.
Ventilator-Induced Lung Injury
Neutrophil elastase inhibitor (sivelestat) attenuates subsequent ventilator-induced lung injury in mice.
Ventilator-Induced Lung Injury
Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury.
Virus Diseases
A Novel ELANE Mutation Associated with Inflammatory Arthritis, Defective NETosis, and Recurrent Parvoviral Infection.
Virus Diseases
Inhibition of human neutrophil elastase by pentacyclic triterpenes.
Virus Diseases
Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma.
Virus Diseases
What is the contribution of respiratory viruses and lung proteases to airway remodelling in asthma and chronic obstructive pulmonary disease?
Wilms Tumor
Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant.
Wiskott-Aldrich Syndrome
Cyclic manner of neutropenia in a patient with HAX-1 mutation.
Wound Infection
PMN-related parameters for the monitoring of wound healing in traumatology.
Wound Infection
Rapid enzyme analysis as a diagnostic tool for wound infection: Comparison between clinical judgment, microbiological analysis, and enzyme analysis.
Wound Infection
Released PMN elastase: an indicator of postsurgical uneventful wound healing and early inflammatory complications. A contribution to the search for objective criteria in wound healing monitoring.
Wound Infection
[Biochemical wound monitoring. PMN elastase in different healing stages after trauma surgery-orthopedic interventions]
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Braun, N.J.; Bodmer, J.L.; Virca, G.D.; Metz-Virca, G.; Maschler, R.; Bieth, J.G.; Schnebli, H.P.
Kinetic studies on the interaction of eglin c with human leukocyte elastase and cathepsin G
Biol. Chem. Hoppe-Seyler
368
299-308
1987
Homo sapiens
brenda
Powers, J.C.; Gupton, B.F.; Harley, A.D.; Nishino, N.; Whitley, R.J.
Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G. Inhibition with peptide chloromethyl ketones
Biochim. Biophys. Acta
485
156-166
1977
Homo sapiens
brenda
Heck, L.W.; Darby, W.L.; Hunter, F.A.; Bhown, A.; Miller, E.J.; Bennett, J.C.
Isolation, characterization, and amino-terminal amino acid sequence analysis of human neutrophil elastase from normal donors
Anal. Biochem.
149
153-162
1985
Homo sapiens
brenda
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Interaction of human leukocyte elastase with soluble and insoluble protein substrates. A practical kinetic approach
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Biochemical and pharmacological characterization of 2-(9-(2-piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4 -(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active elastase inhibitor
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Homo sapiens
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A kinetic study of the hydrolysis of the N-tosylalanine ester of 3-hydroxy-5-phenylpyrrole and related compounds by human leukocyte elastase
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Homo sapiens
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Human leucocyte elastase (HLE) preferentially cleaves the heavy chain H2 of inter-alpha-trypsin inhibitor (ITI)
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Homo sapiens
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Homo sapiens (P08246), Homo sapiens
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Homo sapiens
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Homo sapiens
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Kinetics of the inhibition of human leukocyte elastase by elafin, a 6-kilodalton elastase-specific inhibitor from human skin
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Homo sapiens
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Alginate, the slime exopolysaccharide of Pseudomonas aeruginosa, binds human leukocyte elastase, retards inhibition by alpha 1-proteinase inhibitor, and accelerates inhibition by secretory leukoprotease inhibitor
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Homo sapiens
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1987
Cricetulus griseus, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus, Sus scrofa
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Homo sapiens, Rattus norvegicus
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Homo sapiens
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Homo sapiens
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Homo sapiens
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1991
Homo sapiens
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Colistin stimulates the activity of neutrophil elastase and Pseudomonas aeruginosa elastase
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2002
Homo sapiens
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Homo sapiens
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Kinetics of proteolysis of hog gastric mucin by human neutrophil elastase and by Pseudomonas aeruginosa elastase
Infect. Immun.
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1988
Homo sapiens
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Potempa, J.; Dubin, A.; Watorek, W.; Travis, J.
An elastase inhibitor from equine leukocyte cytosol belongs to the serpin superfamily. Further characterization and amino acid sequence of the reactive center
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Equus caballus, Homo sapiens
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Doring, G.; Frank, F.; Boudier, C.; Herbert, S.; Fleischer, B.; Bellon, G.
Cleavage of lymphocyte surface antigens CD2, CD4, and CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis
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Homo sapiens
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Uejima, Y.; Kokubo, M.; Oshida, J.; Kawabata, H.; Kato, Y.; Fujii, K.
5-Methyl-4H-3,1-benzoxazin-4-one derivatives: specific inhibitors of human leukocyte elastase
J. Pharmacol. Exp. Ther.
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Cricetulus griseus, Homo sapiens
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Rees, D.D.; Brain, J.D.; Wohl, M.E.; Humes, J.L.; Mumford, R.A.
Inhibition of neutrophil elastase in CF sputum by L-658,758
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283
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Homo sapiens
brenda
Wei, L.; Lai, Z.; Gan, X.; Alliston, K.R.; Zhong, J.; Epp, J.B.; Tu, J.; Perera, A.B.; Van Stipdonk, M.; Groutas, W.C.
Mechanism-based inactivation of human leukocyte elastase via an enzyme-induced sulfonamide fragmentation process
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429
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2004
Homo sapiens
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Beyer, G.; Melzig, M.F.
Effects of propolis on hypoxanthine-xanthine oxidase-induced toxicity in cultivated human cells and on neutrophil elastase activity
Biol. Pharm. Bull.
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2005
Homo sapiens
brenda
Shao, M.X.; Nadel, J.A.
Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme
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2005
Homo sapiens
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Meyer-Hoffert, U.; Wingertszahn, J.; Wiedow, O.
Human leukocyte elastase induces keratinocyte proliferation by epidermal growth factor receptor activation
J. Invest. Dermatol.
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2004
Homo sapiens
brenda
Maffia, P.C.; Zittermann, S.E.; Scimone, M.L.; Tateosian, N.; Amiano, N.; Guerrieri, D.; Lutzky, V.; Rosso, D.; Romeo, H.E.; Garcia, V.E.; Issekutz, A.C.; Chuluyan, H.E.
Neutrophil elastase converts human immature dendritic cells into transforming growth factor-beta1-secreting cells and reduces allostimulatory ability
Am. J. Pathol.
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2007
Homo sapiens
brenda
Roghanian, A.; Drost, E.M.; MacNee, W.; Howie, S.E.; Sallenave, J.M.
Inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase
Am. J. Respir. Crit. Care Med.
174
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2006
Homo sapiens
brenda
Rescher, U.; Goebeler, V.; Wilbers, A.; Gerke, V.
Proteolytic cleavage of annexin 1 by human leukocyte elastase
Biochim. Biophys. Acta
1763
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2006
Homo sapiens
brenda
Lombard, C.; Arzel, L.; Bouchu, D.; Wallach, J.; Saulnier, J.
Human leukocyte elastase hydrolysis of peptides derived from human elastin exon 24
Biochimie
88
1915-1921
2006
Homo sapiens
brenda
Schietroma, M.; Carlei, F.; Cappelli, S.; Pescosolido, A.; Lygidakis, N.J.; Amicucci, G.
Effects of cholecystectomy (laparoscopic versus open) on PMN-elastase
Hepatogastroenterology
54
342-345
2007
Homo sapiens
brenda
Thusberg, J.; Vihinen, M.
Bioinformatic analysis of protein structure-function relationships: case study of leukocyte elastase (ELA2) missense mutations
Hum. Mutat.
27
1230-1243
2006
Homo sapiens (P08246), Homo sapiens
brenda
Sonawane, A.; Jyot, J.; During, R.; Ramphal, R.
Neutrophil elastase an innate immunity effector molecule represses flagellin transcription in Pseudomonas aeruginosa
Infect. Immun.
74
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2006
Homo sapiens
brenda
Campbell, E.J.; Owen, C.A.
The sulfate groups of chondroitin sulfate- and heparan sulfate-containing proteoglycans in neutrophil plasma membranes are novel binding sites for human leukocyte elastase and cathepsin G
J. Biol. Chem.
282
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2007
Homo sapiens
brenda
Dell'Aica, I.; Sartor, L.; Galletti, P.; Giacomini, D.; Quintavalla, A.; Calabrese, F.; Giacometti, C.; Brunetta, E.; Piazza, F.; Agostini, C.; Garbisa, S.
Inhibition of leukocyte elastase, polymorphonuclear chemoinvasion, and inflammation-triggered pulmonary fibrosis by a 4-alkyliden-beta-lactam with a galloyl moiety
J. Pharmacol. Exp. Ther.
316
539-546
2006
Homo sapiens
brenda
Santagati, N.A.; Salerno, L.; Di Giacomo, C.; Vanella, L.; Ronsisvalle, S.
Inhibition of human leukocyte elastase by novel thieno-1,3-oxazin-4-ones and thieno-1,3-thioxazin-4-ones
Lett. Drug Des. Discov.
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2007
Homo sapiens
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brenda
Woods, D.E.; Cantin, A.; Cooley, J.; Kenney, D.M.; Remold-O'Donnell, E.
Aerosol treatment with MNEI suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection
Pediatr. Pulmonol.
39
141-149
2005
Homo sapiens, Rattus norvegicus
brenda
Attucci, S.; Gauthier, A.; Korkmaz, B.; Delepine, P.; Martino, M.F.; Saudubray, F.; Diot, P.; Gauthier, F.
EPI-hNE4, a proteolysis-resistant inhibitor of human neutrophil elastase and potential anti-inflammatory drug for treating cystic fibrosis
J. Pharmacol. Exp. Ther.
318
803-809
2006
Homo sapiens
brenda
Chan, S.C.; Leung, V.O.; Ip, M.S.; Shum, D.K.
Shed syndecan-1 restricts neutrophil elastase from alpha1-antitrypsin in neutrophilic airway inflammation
Am. J. Respir. Cell Mol. Biol.
41
620-628
2009
Homo sapiens
brenda
Padron-Barthe, L.; Courta, J.; Lepretre, C.; Nagbou, A.; Torriglia, A.
Leukocyte Elastase Inhibitor, the precursor of L-DNase II, inhibits apoptosis by interfering with caspase-8 activation
Biochim. Biophys. Acta
1783
1755-1766
2008
Homo sapiens
brenda
Kaellquist, L.; Hansson, M.; Persson, A.M.; Janssen, H.; Calafat, J.; Tapper, H.; Olsson, I.
The tetraspanin CD63 is involved in granule targeting of neutrophil elastase
Blood
112
3444-3454
2008
Homo sapiens
brenda
Alla, V.; Kashyap, A.; Gregor, S.; Theobald, M.; Heid, H.; Galle, P.R.; Strand, D.; Strand, S.
Human leukocyte elastase counteracts matrix metalloproteinase-7 induced apoptosis resistance of tumor cells
Cancer Lett.
268
331-339
2008
Homo sapiens
brenda
Mehner, C.; Mueller, D.; Kehraus, S.; Hautmann, S.; Guetschow, M.; Koenig, G.M.
New peptolides from the cyanobacterium Nostoc insulare as selective and potent inhibitors of human leukocyte elastase
ChemBioChem
9
2692-2703
2008
Homo sapiens
brenda
de Lange, T.E.; Simsek, S.; Kramer, M.H.; Nanayakkara, P.W.
A case of cocaine-induced panhypopituitarism with human neutrophil elastase-specific anti-neutrophil cytoplasmic antibodies
Eur. J. Endocrinol.
160
499-502
2009
Homo sapiens
brenda
Kelly, E.; Greene, C.M.; McElvaney, N.G.
Targeting neutrophil elastase in cystic fibrosis
Expert Opin. Ther. Targets
12
145-157
2008
Homo sapiens
brenda
Henriksen, P.A.; Sallenave, J.M.
Human neutrophil elastase: mediator and therapeutic target in atherosclerosis
Int. J. Biochem. Cell Biol.
40
1095-1100
2008
Homo sapiens
brenda
Lepretre, C.; Scovassi, A.I.; Shah, G.M.; Torriglia, A.
Regulation of poly(ADP-ribose) polymerase-1 functions by leukocyte elastase inhibitor/LEI-derived DNase II during caspase-independent apoptosis
Int. J. Biochem. Cell Biol.
41
1046-1054
2009
Homo sapiens
brenda
Roghanian, A.; Sallenave, J.M.
Neutrophil elastase (NE) and NE inhibitors: canonical and noncanonical functions in lung chronic inflammatory diseases (cystic fibrosis and chronic obstructive pulmonary disease)
J. Aerosol Med. Pulm. Drug Deliv.
21
125-144
2008
Homo sapiens
brenda
Nishiyama, T.
Changes in polymorphonuclear leukocyte elastase concentrations and hemolysis parameters in patients transfused with different blood preparations, and in the blood preparations themselves
J. Anesth.
22
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2008
Homo sapiens
brenda
Toyama, S.; Hatori, F.; Shimizu, A.; Takagi, T.
A neutrophil elastase inhibitor, sivelestat, improved respiratory and cardiac function in pediatric cardiovascular surgery with cardiopulmonary bypass
J. Anesth.
22
341-346
2008
Homo sapiens
brenda
Guyot, N.; Butler, M.W.; McNally, P.; Weldon, S.; Greene, C.M.; Levine, R.L.; ONeill, S.J.; Taggart, C.C.; McElvaney, N.G.
Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis
J. Biol. Chem.
283
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2008
Homo sapiens
brenda
Huang, W.; Yamamoto, Y.; Li, Y.; Dou, D.; Alliston, K.R.; Hanzlik, R.P.; Williams, T.D.; Groutas, W.C.
X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives
J. Med. Chem.
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2008
Homo sapiens
brenda
Averhoff, P.; Kolbe, M.; Zychlinsky, A.; Weinrauch, Y.
Single residue determines the specificity of neutrophil elastase for Shigella virulence factors
J. Mol. Biol.
377
1053-1066
2008
Homo sapiens
brenda
Ujiie, Y.; Shimada, A.; Komatsu, K.; Gomi, K.; Oida, S.; Arai, T.; Fukae, M.
Degradation of noncollagenous components by neutrophil elastase reduces the mechanical strength of rat periodontal ligament
J. Periodont. Res.
43
22-31
2008
Homo sapiens
brenda
Koizumi, M.; Fujino, A.; Fukushima, K.; Kamimura, T.; Takimoto-Kamimura, M.
Complex of human neutrophil elastase with 1/2SLPI
J. Synchrotron Radiat.
15
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2008
Homo sapiens
brenda
Goulet, B.; Markovic, Y.; Leduy, L.; Nepveu, A.
Proteolytic processing of cut homeobox 1 by neutrophil elastase in the MV4;11 myeloid leukemia cell line
Mol. Cancer Res.
6
644-653
2008
Homo sapiens
brenda
Matsuoka, T.; Jin, E.; Tachihara, A.; Ghazizadeh, M.; Nakajima, A.; Yoshino, S.; Katayama, Y.; Kawanami, O.
Induction of pulmonary thromboembolism by neutrophil elastase in collagen-induced arthritis mice and effect of recombinant human soluble thrombomodulin
Pathobiology
75
295-305
2008
Homo sapiens
brenda
Ekenaes, C.; Zebrowska, A.; Schuler, B.; Vrede, T.; Andreasen, K.; Backlund, A.; Merfort, I.; Bohlin, L.
Screening for anti-inflammatory activity of 12 Arnica (Asteraceae) species assessed by inhibition of NF-kappaB and release of human neutrophil elastase
Planta Med.
74
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2008
Homo sapiens
brenda
Wang, Z.; Chen, F.; Zhai, R.; Zhang, L.; Su, L.; Lin, X.; Thompson, T.; Christiani, D.C.
Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development
PLoS ONE
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2009
Homo sapiens
brenda
Sullivan, A.L.; Dafforn, T.; Hiemstra, P.S.; Stockley, R.A.
Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex
Respir. Res.
9
60
2008
Homo sapiens
brenda
Hashimoto, S.; Okayama, Y.; Shime, N.; Kimura, A.; Funakoshi, Y.; Kawabata, K.; Ishizaka, A.; Amaya, F.
Neutrophil elastase activity in acute lung injury and respiratory distress syndrome
Respirology
13
581-584
2008
Homo sapiens
brenda
Arakawa, N.S.; Schorr, K.; Ambrosio, S.R.; Merfort, I.; Da Costa, F.B.
Further sesquiterpene lactones from Viguiera robusta and the potential anti-inflammatory activity of a heliangolide: inhibition of human neutrophil elastase release
Z. Naturforsch. C
63
533-538
2008
Homo sapiens
brenda
Suzuki, T.; Yamashita, C.; Zemans, R.L.; Briones, N.; Van Linden, A.; Downey, G.P.
Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-kappaB-, and p53-dependent pathway
Am. J. Respir. Cell Mol. Biol.
41
742-755
2009
Homo sapiens
brenda
Lepretre, C.; Sidoli, G.; Scovassi, A.I.; Torriglia, A.
Leukocyte elastase inhibitor: a new regulator of PARP-1
Ann. N. Y. Acad. Sci.
1171
25-31
2009
Homo sapiens
brenda
Aimetti, A.A.; Tibbitt, M.W.; Anseth, K.S.
Human neutrophil elastase responsive delivery from poly(ethylene glycol) hydrogels
Biomacromolecules
10
1484-1489
2009
Homo sapiens
brenda
Shreder, K.R.; Cajica, J.; Du, L.; Fraser, A.; Hu, Y.; Kohno, Y.; Lin, E.C.; Liu, S.J.; Okerberg, E.; Pham, L.; Wu, J.; Kozarich, J.W.
Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase
Bioorg. Med. Chem. Lett.
19
4743-4746
2009
Homo sapiens
brenda
Xu, G.H.; Kim, Y.H.; Chi, S.W.; Choo, S.J.; Ryoo, I.J.; Ahn, J.S.; Yoo, I.D.
Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa
Bioorg. Med. Chem. Lett.
20
513-515
2010
Homo sapiens
brenda
Inoue, Y.; Omodani, T.; Shiratake, R.; Okazaki, H.; Kuromiya, A.; Kubo, T.; Sato, F.
Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury
Bioorg. Med. Chem.
17
7477-7486
2009
Homo sapiens
brenda
Skokowa, J.; Fobiwe, J.P.; Dan, L.; Thakur, B.K.; Welte, K.
Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1
Blood
114
3044-3051
2009
Homo sapiens
brenda
Gruber, R.; Nadir, J.; Haas, R.
Neutrophil elastase activity and concentrations of interleukin1-beta in crevicular fluid after immediate replacement and immediate loading of implants
Br. J. Oral Maxillofac. Surg.
48
228-231
2010
Homo sapiens
brenda
Ewen, D.; Clarke, S.L.; Smith, J.R.; Berger, C.; Salmon, G.; Trevethick, M.; Shute, J.K.
The role of protease-activated receptors PAR-1 and PAR-2 in the repair of 16HBE 14o(-) epithelial cell monolayers in vitro
Clin. Exp. Allergy
40
435-449
2010
Homo sapiens
brenda
Fischer, B.M.; Domowicz, D.A.; Zheng, S.; Carter, J.L.; McElvaney, N.G.; Taggart, C.; Lehmann, J.R.; Voynow, J.A.; Ghio, A.J.
Neutrophil elastase increases airway epithelial nonheme iron levels
Clin. Transl. Sci.
2
333-339
2009
Homo sapiens
brenda
Kawahara, Y.; Ninomiya, I.; Fujimura, T.; Funaki, H.; Nakagawara, H.; Takamura, H.; Oyama, K.; Tajima, H.; Fushida, S.; Inaba, H.; Kayahara, M.
Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer
Dis. Esophagus
23
329-339
2010
Homo sapiens
brenda
Kobayashi, M.; Irinoda, T.; Akiyama, Y.; Meguro, E.; Hayakawa, Y.; Funato, O.; Takagane, A.
Effect of a selective neutrophil elastase inhibitor on early recovery from body water imbalance after transthoracic esophagectomy
Dis. Esophagus
23
565-571
2010
Homo sapiens
brenda
Hsieh, P.W.; Yu, H.P.; Chang, Y.J.; Hwang, T.L.
Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats
Eur. J. Med. Chem.
45
3111-3115
2010
Homo sapiens
brenda
Hajjar, E.; Broemstrup, T.; Kantari, C.; Witko-Sarsat, V.; Reuter, N.
Structures of human proteinase 3 and neutrophil elastase - so similar yet so different
FEBS J.
277
2238-2254
2010
Homo sapiens (P08246), Homo sapiens
brenda
Ikegame, Y.; Yamashita, K.; Hayashi, S.I.; Yoshimura, S.I.; Nakashima, S.; Iwama, T.
Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edema
Hypertens. Res.
33
703-707
2010
Homo sapiens
brenda
Duvoix, A.; Mackay, R.M.; Henderson, N.; McGreal, E.; Postle, A.; Reid, K.; Clark, H.
Physiological concentration of calcium inhibits elastase-induced cleavage of a functional recombinant fragment of surfactant protein D
Immunobiology
216
72-79
2010
Homo sapiens, Pseudomonas aeruginosa
brenda
Fujii, M.; Miyagi, Y.; Bessho, R.; Nitta, T.; Ochi, M.; Shimizu, K.
Effect of a neutrophil elastase inhibitor on acute lung injury after cardiopulmonary bypass
Interact. Cardiovasc. Thorac. Surg.
10
859-862
2010
Homo sapiens
brenda
Abe, T.; Usui, A.; Oshima, H.; Akita, T.; Ueda, Y.
A pilot randomized study of the neutrophil elastase inhibitor, Sivelestat, in patients undergoing cardiac surgery
Interact. Cardiovasc. Thorac. Surg.
9
236-240
2009
Homo sapiens
brenda
Ho, S.C.; Lee, K.Y.; Chan, Y.F.; Kuo, L.W.; Ito, K.; Adcock, I.M.; Chen, B.C.; Sheu, J.R.; Lin, C.H.; Kuo, H.P.
Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor
J. Immunol.
183
411-420
2009
Homo sapiens
brenda
Weldon, S.; McNally, P.; McElvaney, N.G.; Elborn, J.S.; McAuley, D.F.; Wartelle, J.; Belaaouaj, A.; Levine, R.L.; Taggart, C.C.
Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation
J. Immunol.
183
8148-8156
2009
Homo sapiens
brenda
Piper, M.G.; Massullo, P.R.; Loveland, M.; Druhan, L.J.; Kindwall-Keller, T.L.; Ai, J.; Copelan, A.; Avalos, B.R.
Neutrophil elastase downmodulates native G-CSFR expression and granulocyte-macrophage colony formation
J. Inflamm.
7
5
2010
Homo sapiens
brenda
Thongyoo, P.; Bonomelli, C.; Leatherbarrow, R.J.; Tate, E.W.
Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold
J. Med. Chem.
52
6197-6200
2009
Homo sapiens
brenda
Mulchande, J.; Oliveira, R.; Carrasco, M.; Gouveia, L.; Guedes, R.C.; Iley, J.; Moreira, R.
4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase
J. Med. Chem.
53
241-253
2010
Homo sapiens
brenda
Kim, Y.H.; Ryoo, I.J.; Choo, S.J.; Xu, G.H.; Lee, S.; Seok, S.J.; Bae, K.; Yoo, I.D.
Clitocybin D, a novel human neutrophil elastase inhibitor from the culture broth of Clitocybe aurantiaca
J. Microbiol. Biotechnol.
19
1139-1141
2009
Homo sapiens
brenda
Hayashi, M.; Oya, A.; Miyake, H.; Nakai, A.; Takeshita, T.
Effect of urinary trypsin inhibitor on preterm labor with high granulocyte elastase concentration in cervical secretions
J. Nippon Med. Sch.
77
80-85
2010
Homo sapiens
brenda
Braun, B.C.; Meyer, H.A.; Reetz, A.; Fuhrmann, U.; Koehrle, J.
Effect of mutations of the human serpin protein corticosteroid-binding globulin on cortisol-binding, thermal and protease sensitivity
J. Steroid Biochem. Mol. Biol.
120
30-37
2010
Homo sapiens
brenda
Salipante, S.J.; Rojas, M.E.; Korkmaz, B.; Duan, Z.; Wechsler, J.; Benson, K.F.; Person, R.E.; Grimes, H.L.; Horwitz, M.S.
Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase
Mol. Cell. Biol.
29
4394-4405
2009
Homo sapiens
brenda
Jackson, P.L.; Xu, X.; Wilson, L.; Weathington, N.M.; Clancy, J.P.; Blalock, J.E.; Gaggar, A.
Human neutrophil elastase-mediated cleavage sites of MMP-9 and TIMP-1: implications to cystic fibrosis proteolytic dysfunction
Mol. Med.
16
159-166
2010
Homo sapiens
brenda
Zynek-Litwin, M.; Kuzniar, J.; Marchewka, Z.; Kopec, W.; Kusztal,M.; Patrzalek, D.; Biecek, P.; Klinger, M.
Plasma and urine leukocyte elastase-alpha1 protease inhibitor complex as a marker of early and long-term kidney graft function
Nephrol. Dial. Transplant.
25
2346-2351
2010
Homo sapiens
brenda
Topic, A.; Ljujic, M.; Nikolic, A.; Petrovic-Stanojevic, N.; Dopudja-Pantic, V.; Mitic-Milikic, M.; Radojkovic, D.
Alpha-1-antitrypsin phenotypes and neutrophil elastase gene promoter polymorphisms in lung cancer
Pathol. Oncol. Res.
17
75-80
2011
Homo sapiens
brenda
Sienczyk, M.; Winiarski, L.; Kasperkiewicz, P.; Psurski, M.; Wietrzyk, J.; Oleksyszyn, J.
Simple phosphonic inhibitors of human neutrophil elastase
Bioorg. Med. Chem. Lett.
21
1310-1314
2011
Homo sapiens
brenda
Dou, D.; He, G.; Kuang, R.; Fu, Q.; Venkataraman, R.; Groutas, W.C.
Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase
Bioorg. Med. Chem.
18
6646-6650
2010
Homo sapiens
brenda
Crocetti, L.; Giovannoni, M.P.; Schepetkin, I.A.; Quinn, M.T.; Khlebnikov, A.I.; Cilibrizzi, A.; Piaz, V.D.; Graziano, A.; Vergelli, C.
Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase
Bioorg. Med. Chem.
19
4460-4472
2011
Homo sapiens
brenda
Ramachandran, R.; Mihara, K.; Chung, H.; Renaux, B.; Lau, C.S.; Muruve, D.A.; DeFea, K.A.; Bouvier, M.; Hollenberg, M.D.
Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2)
J. Biol. Chem.
286
24638-24648
2011
Homo sapiens
brenda
Papayannopoulos, V.; Metzler, K.D.; Hakkim, A.; Zychlinsky, A.
Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps
J. Cell Biol.
191
677-691
2010
Homo sapiens
brenda
Estacio, S.G.; Moreira, R.; Guedes, R.C.
Characterizing the dynamics and ligand-specific interactions in the human leukocyte elastase through molecular dynamics simulations
J. Chem. Inf. Model.
51
1690-1702
2011
Homo sapiens
brenda
Hansen, G.; Gielen-Haertwig, H.; Reinemer, P.; Schomburg, D.; Harrenga, A.; Niefind, K.
Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor
J. Mol. Biol.
409
681-691
2011
Homo sapiens (P08246), Homo sapiens
brenda
Nogami, K.; Ogiwara, K.; Matsumoto, T.; Nishiya, K.; Takeyama, M.; Shima, M.
Mechanisms of human neutrophil elastase-catalysed inactivation of factor VIII(a)
Thromb. Haemost.
105
968-980
2011
Homo sapiens
brenda
Madoiwa, S.; Tanaka, H.; Nagahama, Y.; Dokai, M.; Kashiwakura, Y.; Ishiwata, A.; Sakata, A.; Yasumoto, A.; Ohmori, T.; Mimuro, J.; Sakata, Y.
Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation
Thromb. Res.
127
349-355
2011
Homo sapiens
brenda
Dokai, M.; Madoiwa, S.; Yasumoto, A.; Kashiwakura, Y.; Ishiwata, A.; Sakata, A.; Makino, N.; Ohmori, T.; Mimuro, J.; Sakata, Y.
Local regulation of neutrophil elastase activity by endogenous alpha1-antitrypsin in lipopolysaccharide-primed hematological cells
Thromb. Res.
128
283-292
2011
Homo sapiens
brenda
Collins, J.; Szardenings, M.; Maywald, F.; Blcker, H.; Frank, R.; Hecht, H.J.; Vasel, B.; Schomburg, D.; Fink, E.; Fritz, H.
Human leukocyte elastase inhibitors: designed variants of human pancreatic secretory trypsin inhibitor (hPSTI)
Biol. Chem. Hoppe-Seyler
371
29-36
1990
Homo sapiens
brenda
Ungurs, M.J.; Sinden, N.J.; Stockley, R.A.
Progranulin is a substrate for neutrophil-elastase and proteinase-3 in the airway and its concentration correlates with mediators of airway inflammation in COPD
Am. J. Physiol. Lung Cell Mol. Physiol.
306
L80-L87
2014
Homo sapiens
brenda
Popow-Stellmaszyk, J.; Wysocka, M.; Lesner, A.; Korkmaz, B.; Rolka, K.
A new proteinase 3 substrate with improved selectivity over human neutrophil elastase
Anal. Biochem.
442
75-82
2013
Homo sapiens
brenda
Lee, H.H.; Sung, M.H.
The neutrophil elastase mutant affects viability and differentiation of the human monocytic THP-1 cell
Cell Biochem. Funct.
31
305-311
2013
Homo sapiens
brenda
Schmelzer, C.E.; Jung, M.C.; Wohlrab, J.; Neubert, R.H.; Heinz, A.
Does human leukocyte elastase degrade intact skin elastin?
FEBS J.
279
4191-4200
2012
Homo sapiens
brenda
Lee, I.; Bae, K.; Kuk Yoo, J.; Ryoo, I.; Kim, B.; Seog Ahn, J.; Yoo, I.
Inhibition of human neutrophil elastase by ergosterol derivatives from the mycelium of Phellinus linteus
J. Antibiot.
65
437-440
2012
Homo sapiens
brenda
Gregory, A.D.; Kliment, C.R.; Metz, H.E.; Kim, K.H.; Kargl, J.; Agostini, B.A.; Crum, L.T.; Oczypok, E.A.; Oury, T.A.; Houghton, A.M.
Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis
J. Leukoc. Biol.
98
143-152
2015
Homo sapiens
brenda
Pivetta, E.; Danussi, C.; Wassermann, B.; Modica, T.M.; Del Bel Belluz, L.; Canzonieri, V.; Colombatti, A.; Spessotto, P.
Neutrophil elastase-dependent cleavage compromises the tumor suppressor role of EMILIN1
Matrix Biol.
34
22-32
2014
Homo sapiens
brenda
Huang, G.; Feng, L.; Liu, B.; He, Y.; Li, Y.; Chen, Y.
Synthesis and biological evaluation of nigranoic acid esters as novel human neutrophil elastase inhibitors
Nat. Prod. Res.
29
1650-1656
2015
Homo sapiens
brenda
Avlonitis, N.; Debunne, M.; Aslam, T.; McDonald, N.; Haslett, C.; Dhaliwal, K.; Bradley, M.
Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase
Org. Biomol. Chem.
11
4414-4418
2013
Homo sapiens
brenda
Feng, L.; Liu, X.; Zhu, W.; Guo, F.; Wu, Y.; Wang, R.; Chen, K.; Huang, C.; Li, Y.
Inhibition of human neutrophil elastase by pentacyclic triterpenes
PLoS ONE
8
e82794
2013
Homo sapiens
brenda
Novovic, S.; Andersen, A.M.; Nord, M.; Astrand, M.; Ottosson, T.; Jorgensen, L.N.; Hansen, M.B.
Activity of neutrophil elastase reflects the progression of acute pancreatitis
Scand. J. Clin. Lab. Invest.
73
485-493
2013
Homo sapiens
brenda
Hochscherf, J.; Pietsch, M.; Tieu, W.; Kuan, K.; Abell, A.D.; Guetschow, M.; Niefind, K.
Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2 site binding inhibitor
Acta Crystallogr. Sect. F
74
480-489
2018
Homo sapiens (P08246), Homo sapiens
brenda
Liu, S.Y.; Xiong, H.; Li, R.R.; Yang, W.C.; Yang, G.F.
Activity-based near-infrared fluorogenic probe for enabling in vitro and in vivo profiling of neutrophil elastase
Anal. Chem.
91
3877-3884
2019
Homo sapiens
brenda
Fu, Z.; Thorpe, M.; Akula, S.; Chahal, G.; Hellman, L.T.
Extended cleavage specificity of human neutrophil elastase, human proteinase 3, and their distant ortholog clawed frog PR3 - three elastases with similar primary but different extended specificities and stability
Front. Immunol.
9
2387
2018
Homo sapiens
brenda
Tan, X.F.; Kim, D.W.; Song, Y.H.; Kim, J.Y.; Yuk, H.J.; Wang, Y.; Curtis-Long, M.J.; Park, K.H.
Human neutrophil elastase inhibitory potential of flavonoids from Campylotropis hirtella and their kinetics
J. Enzyme Inhib. Med. Chem.
31
16-22
2016
Homo sapiens
brenda
Yang, R.; Zhong, L.; Yang, X.Q.; Jiang, K.L.; Li, L.; Song, H.; Liu, B.Z.
Neutrophil elastase enhances the proliferation and decreases apoptosis of leukemia cells via activation of PI3K/Akt signaling
Mol. Med. Rep.
13
4175-4182
2016
Homo sapiens
brenda
Wiesmeier, M.; Gautam, S.; Kirschnek, S.; Haecker, G.
Characterisation of neutropenia-associated neutrophil elastase mutations in a murine differentiation model in vitro and in vivo
PLoS ONE
11
e0168055
2016
Homo sapiens, Mus musculus
brenda
Macleod, T.; Doble, R.; McGonagle, D.; Wasson, C.W.; Alase, A.; Stacey, M.; Wittmann, M.
Neutrophil elastase-mediated proteolysis activates the anti-inflammatory cytokine IL-36 receptor antagonist
Sci. Rep.
6
24880
2016
Homo sapiens
brenda
3.4.21.37 leukocyte elastase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
