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Information on EC 3.4.21.35 - tissue kallikrein and Organism(s) Rattus norvegicus and UniProt Accession P00758
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3.4.21.35 tissue kallikreinSpecify your search results
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- 3.4.21.35
- kallikreins
-
prostatectomy
-
gleason
- androgen
- rectal
- hyperplasia
-
transrectal
-
ultrasound
-
preoperative
- adenocarcinoma
-
prostate-specific
-
seminal
- lymph
-
followup
- metastases
-
radiotherapy
-
postoperative
-
needle
- urological
-
staging
-
pelvic
- bradykinin
-
lncap
-
transurethral
-
beam
-
retropubic
-
kallikrein-kinin
- kininogens
-
ultrasonography
-
sextant
-
suspicious
-
brachytherapy
-
nadir
-
extraprostatic
-
urologist
- aprotinin
-
immunosensors
-
actuarial
-
ultrasound-guided
-
multiparametric
- incontinence
-
lymphadenectomy
-
transperineal
-
antiandrogens
- hk2
-
organ-confined
-
extracapsular
- biotechnology
- medicine
- drug development
- finasteride
-
kininase
-
mcrpc
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds
Synonyms
prostate specific antigen, tissue kallikrein, glandular kallikrein, renal kallikrein, trypsin-like serine protease, prokallikrein, klk15, salivary kallikrein, glandular kallikrein 2, urinary kallidinogenase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
bradykininogenase
-
-
-
-
callicrein
-
-
-
-
depot-Padutin
-
-
-
-
dilminal D
-
-
-
-
glandular kallikrein
-
-
-
-
glumorin
-
-
-
-
kallidinogenase
kallikrein
kallikrein 1
-
-
-
-
kidney/pancreas/salivary gland kallikrein
-
-
-
-
kininogenase
-
-
-
-
kininogenin
-
-
-
-
KLK-S3
-
-
-
-
onokrein P.
-
-
-
-
P1 kallikrein
-
-
-
-
padreatin
-
-
-
-
padutin
-
-
-
-
pancreatic kallikrein
-
-
-
-
PPK
-
-
-
-
Prk
-
-
-
-
PS kallikrein
-
-
-
-
renal tissue kallikrein
-
-
-
-
RSGK-50
-
-
-
-
RUK
-
-
-
-
S01.160
-
-
-
-
S1 kallikrein
-
-
-
-
S2 kallikrein
-
-
-
-
S3 kallikrein
-
-
-
-
salivary kallikrein
-
-
-
-
SEV
-
-
-
-
submandibular enzymatic vasoconstrictor
-
-
-
-
T-kininogenase
-
-
-
-
urinary kallikrein
urokallikrein
-
-
-
-
kallidinogenase
-
-
-
-
kallikrein
-
-
-
-
urinary kallikrein
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
389069-73-2
-
9001-01-8
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
angiotensin I + H2O
?
-
reaction with prostate enzyme, very low reaction with submandibular enzyme
-
-
?
angiotensinogen + H2O
?
-
reaction with prostate enzyme, no reaction with submandibular enzyme
-
-
?
benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin + H2O
benzoyl-Phe-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzoyl-Pro-Phe-Arg-p-nitroanilide + H2O
benzoyl-Pro-Phe-Arg + p-nitroaniline
-
-
-
-
?
benzyloxycarbonyl-Arg methyl ester + H2O
benzyloxycarbonyl-Arg + methanol
-
-
-
-
?
Benzyloxycarbonyl-Lys methyl ester + H2O
Benzyloxycarbonyl-Lys + methanol
-
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
D-Val-Leu-Arg-p-nitroanilide + H2O
D-Val-Leu-Arg + p-nitroaniline
-
-
-
-
?
D-Val-Leu-Lys-4-nitroanilide + H2O
D-Val-Leu-Lys + 4-nitroaniline
-
-
-
-
?
DL-Val-Leu-Arg-p-nitroanilide + H2O
DL-Val-Leu-Arg + p-nitroaniline
-
-
-
-
?
epithelial sodium channel + H2O
activated epithelial sodium channel + ?
-
-
-
-
?
kinin B2 receptor + H2O
?
-
tissue kallikrein directly activates kinin B2 receptor in the absence of kininogen
-
-
?
kininogen + H2O
bradykinin + kinin heavy chain + kinin light chain
-
cleavage of rat kininogen at Arg-Arg and Arg-Ser
-
?
L-Pro-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
L-Pro-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-alpha-acetyl-Tyr ethyl ester + H2O
N-alpha-acetyl-Tyr + ethanol
-
-
-
-
?
N-alpha-benzoyl-L-Arg ethyl ester + H2O
N-alpha-benzoyl-L-Arg + ethanol
-
-
-
-
?
o-aminobenzoyl-FRAPR-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
-
-
-
?
o-aminobenzoyl-FRLVR-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
-
-
-
?
o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-GFSPFR + APRVQ-ethylenediamine 2,4-dinitrophenol + o-aminobenzoyl-GFSPF + RAPRVQ-ethylenediamine 2,4-dinitrophenol
-
preferentially hydrolyzed at Phe-Arg bond compared with Phe-Arg
-
-
?
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-GFSPFR + SVTVQ-ethylenediamine 2,4-dinitrophenol
-
-
-
-
?
o-aminobenzoyl-MTEMARRPPGFSPFRSVTVQ-NH2 + H2O
o-aminobenzoyl-MTEMAR + RPPGFSPFR + SVTVQ-NH2
-
-
RPPGFSPFR is bradykinin
-
?
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-MTEMAR + RPQ-ethylenediamine 2,4-dinitrophenol
-
-
-
-
?
o-aminobenzoyl-MTSVIRRPPGFSPFRAPRV-NH2 + H2O
o-aminobenzoyl-MTSVIR + RPPGFSPFR + APRV-NH2
-
-
RPPGFSPFR is bradykinin
-
?
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-MTSVIR + RPQ-ethylenediamine 2,4-dinitrophenol
-
slow hydrolysis
-
-
?
o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-Phe-Arg + Arg-ethylenediamine 2,4-dinitrophenol
-
slow hydrolysis
-
-
?
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol + H2O
o-aminobenzoyl-Phe-Arg + Lys-ethylenediamine 2,4-dinitrophenol
-
slow hydrolysis
-
-
?
o-aminobenzoyl-SVIRRVQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
-
-
-
?
o-aminobenzoyl-TSVIRRPQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O
?
-
-
-
-
?
Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O
Pro-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Tosyl-Arg methyl ester + H2O
Tosyl-Arg + methanol
-
-
-
-
?
tosyl-Gly-Pro-Arg-p-nitroanilide + H2O
tosyl-Gly-Pro-Arg + p-nitroaniline
-
-
-
-
?
D-Val-Leu-Arg-4-nitroanilide + H2O
D-Val-Leu-Arg + 4-nitroaniline
-
-
-
-
?
D-Val-Leu-Arg-4-nitroanilide + H2O
D-Val-Leu-Arg + 4-nitroaniline
-
also known as S2266, a chromogenic substrate for tissue kallikrein
-
-
?
D-Val-Leu-Arg-4-nitroanilide + H2O
D-Val-Leu-Arg + 4-nitroaniline
-
S-2266, selective tissue kallikrein substrate
-
-
?
kininogen + H2O
kinin + ?
-
high molecular weight kininogen from human and rat
-
?
kininogen + H2O
kinin + ?
-
rat low molecular weight kininogen and bovine low molecular weight kininogen, T-kininogen
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
-
-
-
?
low-molecular-weight kininogen + H2O
kallidin + kinin
-
bovine or human
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
epithelial sodium channel + H2O
activated epithelial sodium channel + ?
-
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Aprotinin
-
tissue kallikrein is inactivated by incubation with 5fold molar excess of aprotinin at 37°C for 1 h
Aprotinin
-
blocks increase of DU145 cell migration and invasion by tissue kallikrein
icatibant
-
minimally affects increase of DU145 cell migration and invasion by tissue kallikrein
additional information
-
kinin has little effect on increase of DU145 cell migration and invasion by tissue kallikrein. Tissue kallikrein-induced cell migration and invasion are abolished by inhibition of PAR1 using a pharmacological inhibitor or RNA interference. The effect of tissue kallikrein on cell migration and invasion are also blocked by inhibitors of protein kinase C, c-Src, matrix metalloproteinase, EGFR and extracellular signal-regulated kinase
-
additional information
-
neutralizing tissue kallikrein antibody delays skin wound healing
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
aldosterone
-
increased aldosterone levels lead to enhanced kallikrein activity
additional information
-
administration of glibenclamide or N,N'-dicyclohexyl-4-morholinecarboxamide increases urinary kallikrein secretion
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00024
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
21.8
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
-
additional information
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
9
-
tosyl-Arg methyl ester hydrolase activity and kininogenase activity of wild-type and recombinant enzyme
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
8 - 10
8 - 10
-
pH 8.0: about 35% of maximal activity, pH 10.0: about 70% of maximal activity
8 - 10
-
pH 8.0: about 60% of maximal activity, pH 10.0: about 55% of maximal activity, kinin releasing activity, prostate
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
physiological function
-
beneficial effects of kallidinogenase on increased retinal vascular permeability and vascular endothelial growth factor in diabetic rats. Improvement in abnormal NO metabolism by kallidinogenase suggesting that the kallikrein-kinin system disturbance is corrected
physiological function
-
tissue kallikrein promotes cell migration and proliferation of HaCaT keratinocytes in a concentration- and time-dependent manner. Active TK stimulates keratinocyte migration independent of kinin, kinin B2 receptor and NO formation. Tissue kallikrein-induced keratinocyte migration is dependent on PAR1 activation and EGFR phosphorylation. Local application of tissue kallikrein promotes skin wound healing. Signaling pathways mediated by tissue kallikrein promote keratinocyte migration through activation of the PAR1-PKC-Src-MMP pathway and HB-EGF/AR shedding-dependent EGFR transactivation
physiological function
-
tissue kallikrein promotes DU145 prostate cancer cell migration in a concentration-dependent manner, but has no effect on A549 lung cancer cells. Tissue kallikrein stimulates DU145 cell proliferation through activation of the kinin B2 receptor, but not PAR1 and EGFR activation. Tissue kallikrein promotes migration and invasion of DU145 cells through PAR1-PKC-Src-MMP activation and EGFR-ERK transactivation. Tissue kallikrein stimulates ERK activation through EGFR transactivation. Differential signaling pathways mediated by tissue kallikrein in promoting prostate cancer cell migration and invasion via PAR1 activation, and proliferation via kinin B2 receptor stimulation. Stimulates ERK phosphorylation
physiological function
-
tissue kallikrein/kinin infusion not only prevents but also reverses kidney injury, inflammation and fibrosis in salt-induced hypertensive rats. Wide time window for kallikrein administration in protection against ischemic brain infarction: delayed kallikrein infusion for 24 h after cerebral ischemia in rats is effective in reducing neurological deficits, infarct size, apoptosis and inflammation. Tissue kallikrein induces contraction of isolated rat uterus in the absence of kinin formation, and elicites cardioprotection by direct kinin B2 receptor activation in kininogen-deficient Brown Norway rats. A subdepressor dose of kallikrein protein or kinin peptide restores impaired cardiac function in rats with postinfarction failure by inhibiting hypertrophy and fibrosis and promoting angiogenesis through increased NO formation and inhibition of oxidative stress and TGF-beta expression. Local application of tissue kallikrein promotes skin wound healing in rats
physiological function
-
tissue kallikrein prevents neurons from hypoxia/reoxygenation damage by influencing the activity of bradykinin B2 receptor followed by activating the ERK1/2 signal pathway, and thus promoting the survival of cortical neurons subjected to ischemia/reperfusion insults
physiological function
-
exogenous tissue kallikrein attenuates the cerebral ischemia/reperfusion induced rat hippocampal CA1 neurons injury through activating the beta-arrestin-2 assembled B2R-Raf-MEK1/2 signaling module
physiological function
-
tissue kallikrein treatment significantly reduces monocyte chemoattractant protein-1, intercellular adhesion molecule-1, and interleukin-6 levels in retinal pigment epithelium-choroid complexes. Tissue kallikrein exhibits antiangiogenic properties by cleaving vascular endothelial growth factor 164 in a laser-induced choroidal neovascularization model
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). KLK1_RAT
261
0
28852
Swiss-Prot
Secretory Pathway (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
38000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
monomer
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
proteolytic modification
side-chain modification
-
multiple forms are due at least in part to varying carbohydrates
proteolytic modification
-
urinary and renal kallikrein exist in both active and proenzyme form
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
freezing and thawing results in at least three-fold increase of specific activity
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, 0.1 N NaCl, 0.01 M sodium phosphate buffer, pH 7.0, stable for months
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
excretion of tissue kallikrein is stimulated following 5 days of a high-K+ or low-Na+ diet in rats
-
indomethacin-treated rats show elevated mean paw tissue kallikrein level as compared with the non-treated arthritic rats. Prednisolone treatment for 9 days to adjuvant arthritic rats results in appreciable raise in the mean paw tissue level as compared to the non-treated arthritic rats. Indomethacin-treated rats also show elevated mean paw tissue kallikrein level as compared to the non-treated arthritic rats
-
prednisolone treatment for 9 days to adjuvant arthritic rats results in reduction in the mean synovial tissue kallikrein level as compared to the non-treated arthritic rats
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
medicine
-
kallikrein improves cardiac function and reduces infarct size in kininogen-deficient rats, icatibant and N-alpha-nitro-L-arginine-methyl-ester block kallikrein's cardioprotective effects
medicine
-
kallidinogenase may be efficacious for simple retinopathy including hyperpermeability in subjects with diabetes
medicine
-
tissue kallikrein administration can remarkably alleviate hypoxia/reoxygenation-induced neuronal injury by reduction of lactate dehydrogenase release and promotion of neuron viability
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (P06870), Macaca fascicularis (Q07276), Mastomys natalensis (P32824), Mus musculus (P00755), Papio hamadryas (Q28773), Rattus norvegicus (P00758)
El Moujahed, A.; Gutman, N.; Brillard, M.; Gauthier, F.
Substrate specificity of two kallikrein family gene products isolated from the rat submandibular gland
FEBS Lett.
265
137-140
1990
Rattus norvegicus
El Moujahed, A.; Brillard-Bourdet, M.; Juliano, M.A.; Moreau, T.; Chagas, J.R.; Gutman, N.; Prado, E.S.; Gauthier, F.
Kininogen-derived fluorogenic substrates for investigating the vasoactive properties of rat kallikreins. Identification of a T-kinin-releasing rat kallikrein
Eur. J. Biochem.
247
652-658
1997
Homo sapiens, Rattus norvegicus
Shimojo, N.; Chao, J.; Chao, L.; Margolius, H.S.; Mayfield, R.K.
Identification and characterization of a tissue kallikrein in rat skeletal muscles
J. Biochem.
243
773-778
1987
Rattus norvegicus
Chao, J.; Chao, L.; Margolius, H.S.
Isolation of tissue kallikrein in rat spleen by monoclonal antibody-affinity chromatography
Biochim. Biophys. Acta
801
244-249
1984
Rattus norvegicus
Wang, J.; Chao, J.; Chao, L.
Purification and characterization of recombinant tissue kallikrein from Escherichia coli and yeast
Biochem. J.
276
63-71
1991
Rattus norvegicus
-
Xiong, W.; Chen, L.M.; Woodley-Miller, C.; Simson, J.A.V.; Chao, J.
Idenification, purification, and localization of tissue kallikrein in rat heart
Biochem. J.
267
639-646
1990
Rattus norvegicus
Bedi, G.S.
Purification of rat urinary kallikrein: comparative studies with rat submandibular gland kallikrein-like serine protease
Prep. Biochem.
22
239-256
1992
Rattus norvegicus
Bailey, G.S.
Rat pancreas kallikrein
Methods Enzymol.
163
115-128
1988
Rattus norvegicus
Chao, J.; Chao, L.
Rat urinary kallikrein
Methods Enzymol.
163
128-143
1988
Rattus norvegicus
Wang, C.; Tang, C.Q.; Zhou, G.X.; Chao, L.; Chao, J.
Biochemical characterization and substrate specificity of rat prostate kallikrein (S3): comparison with tissue kallikrein, tonin and T-kininogenase
Biochim. Biophys. Acta
1121
309-316
1992
Rattus norvegicus
Fogaca, S.E.; Melo, R.L.; Pimenta, D.C.; Hosoi, K.; Juliano, L.; Juliano, M.A.
Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins
Biochem. J.
380
775-781
2004
Homo sapiens, Mus musculus, Rattus norvegicus
Oddo, E.M.; De Luca Sarobe, V.; Krmar, R.; Martin, R.S.; Ibarra, F.R.; Arrizurieta, E.E.
Urinary kallikrein and blood pressure - gender-different response to potassium supplementation in SHR. Role of aldosterone
Nephron. Physiol.
108
p37-p45
2008
Rattus norvegicus
Bledsoe, G.; Shen, B.; Yao, Y.Y.; Hagiwara, M.; Mizell, B.; Teuton, M.; Grass, D.; Chao, L.; Chao, J.
Role of tissue kallikrein in prevention and recovery of gentamicin-induced renal injury
Toxicol. Sci.
102
433-443
2008
Rattus norvegicus
Smith, R.S.; Gao, L.; Chao, L.; Chao, J.
Tissue kallikrein and kinin infusion promotes neovascularization in limb ischemia
Biol. Chem.
389
725-730
2008
Rattus norvegicus
Kamata, Y.; Fujita, T.; Kato, T.; Hayashi, I.; Kurosaka, M.; Katori, M.; Fujita, Y.; Majima, M.
An ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein
Hypertens. Res.
32
220-226
2009
Rattus norvegicus
Chao, J.; Yin, H.; Gao, L.; Hagiwara, M.; Shen, B.; Yang, Z.R.; Chao, L.
Tissue kallikrein elicits cardioprotection by direct kinin b2 receptor activation independent of kinin formation
Hypertension
52
715-720
2008
Rattus norvegicus
Chao, J.; Shen, B.; Gao, L.; Xia, C.F.; Bledsoe, G.; Chao, L.
Tissue kallikrein in cardiovascular, cerebrovascular and renal diseases and skin wound healing
Biol. Chem.
391
345-355
2010
Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Gao, L.; Smith, R.S.; Chen, L.M.; Chai, K.X.; Chao, L.; Chao, J.
Tissue kallikrein promotes prostate cancer cell migration and invasion via protease-activated receptor-1-dependent signaling pathway
Biol. Chem.
391
803-812
2010
Homo sapiens, Rattus norvegicus
Kato, N.; Hou, Y.; Lu, Z.; Lu, C.; Nagano, H.; Suzuma, K.; Takagi, H.; Matsumoto, Y.
Kallidinogenase normalizes retinal vasopermeability in streptozotocin-induced diabetic rats: potential roles of vascular endothelial growth factor and nitric oxide
Eur. J. Pharmacol.
606
187-190
2009
Rattus norvegicus
Gao, L.; Chao, L.; Chao, J.
A novel signaling pathway of tissue kallikrein in promoting keratinocyte migration: activation of proteinase-activated receptor 1 and epidermal growth factor receptor
Exp. Cell Res.
316
376-389
2010
Rattus norvegicus
Liu, L.; Liu, H.; Yang, F.; Chen, G.; Zhou, H.; Tang, M.; Zhang, R.; Dong, Q.
Tissue kallikrein protects cortical neurons against hypoxia/reoxygenation injury via the ERK1/2 pathway
Biochem. Biophys. Res. Commun.
407
283-287
2011
Rattus norvegicus
Sharma, J.N.
Modifications in tissue kallikrein activity with indomethacin and prednisolone treatment in arthritic rats
Inflammopharmacology
18
113-117
2010
Rattus norvegicus
Patel, A.B.; Chao, J.; Palmer, L.G.
Tissue kallikrein activation of the epithelial Na channel
Am. J. Physiol. Renal. Physiol.
303
F540-550
2012
Rattus norvegicus
Fukuhara, J.; Noda, K.; Murata, M.; Namba, S.; Kinoshita, S.; Dong, Z.; Ando, R.; Lennikov, A.; Kanda, A.; Ishida, S.
Tissue kallikrein attenuates choroidal neovascularization via cleavage of vascular endothelial growth factor
Invest. Ophthalmol. Vis. Sci.
54
274-279
2013
Rattus norvegicus
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Transporter Classification Database (TCDB): 8.A.131.1.5
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