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Abz-EPFWEDQ-EDDnp + H2O
?
-
-
-
?
Abz-GIAPFCDLMPEQ-EDDnp + H2O
?
-
-
-
?
Abz-GIATFCDLMPEQ-EDDnp + H2O
?
-
-
-
?
Abz-GIATFCMLMPEQ-EDDnp + H2O
?
-
-
-
?
Abz-GIATFCPLMPEQ-EDDnp + H2O
?
-
-
-
?
Abz-GIATFCRLMPEQ-EDDnp + H2O
?
-
-
-
?
Abz-GIATFDMLMPEQ-EDDnp + H2O
?
-
-
-
?
Abz-GIATFRMLMPEQ-EDDnp + H2O
?
-
-
-
?
Abz-GIATFSMLMPEQ-EDDnp + H2O
?
-
-
-
?
Abz-GIATFWMLMPEQ-EDDnp + H2O
?
-
-
-
?
Abz-GIEPFSDPMPEQ-EDDnp + H2O
?
-
-
-
?
Abz-GIEPKSDPMPEQ-EDDnp + H2O
?
-
-
-
?
Abz-GIEPKSDPMPEQ-N-EDDnp + H2O
?
-
-
-
?
Abz-TPFSALQ-EDDnp + H2O
?
-
-
-
?
Abz-TPKSALQ-EDDnp + H2O
?
-
-
-
?
Abz-TPWSALQ-YNO2 + H2O
?
-
-
-
?
angiotensin I + H2O
angiotensin II + ?
-
-
-
?
angiotensinogen + H2O
angiotensin I + ?
-
-
-
?
angiotensinogen + H2O
angiotensin II + ?
-
-
-
?
low-density lipoprotein + H2O
?
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + p-nitroaniline
assay at pH 7.4, 25°C
-
-
?
(7-aminocoumarin-4-yl)acetyl-Gly-His(Bzl)-Tle-Pro-Phe-norvaline-Asp-3-Pal-Gly-Lys(DNP)-Gly-NH2 + H2O
(7-aminocoumarin-4-yl)acetyl-Gly-His(Bzl)-Tle-Pro-Phe + norvaline-Asp-3-Pal-Gly-Lys(DNP)-Gly-NH2
-
-
-
-
?
(7-aminocoumarin-4-yl)acetyl-Gly-His(Bzl)-Tle-Pro-Phe-Ser-Asp-Lys(Tfa)-Gly-Lys(DNP)-Gly-NH2 + H2O
(7-aminocoumarin-4-yl)acetyl-Gly-His(Bzl)-Tle-Pro-Phe + Ser-Asp-Lys(Tfa)-Gly-Lys(DNP)-Gly-NH2
-
-
-
-
?
(7-aminocoumarin-4-yl)acetyl-Gly-His(Bzl)-Tle-Pro-Phe-Ser-Asp-Met(O)-Gly-Lys(DNP)-Gly-NH2 + H2O
(7-aminocoumarin-4-yl)acetyl-Gly-His(Bzl)-Tle-Pro-Phe + Ser-Asp-Met(O)-Gly-Lys(DNP)-Gly-NH2
-
-
-
-
?
(7-aminocoumarin-4-yl)acetyl-Gly-Phe(F)5-Tle-Pro-Phe-norvaline-Asp-3-Pal-Gly-Lys(DNP)-Gly-NH2 + H2O
(7-aminocoumarin-4-yl)acetyl-Gly-Phe(F)5-Tle-Pro-Phe + norvaline-Asp-3-Pal-Gly-Lys(DNP)-Gly-NH2
-
-
-
-
?
(7-aminocoumarin-4-yl)acetyl-Gly-Phe(F)5-Tle-Pro-Phe-norvaline-Asp-Met(O)2-Gly-Lys(DNP)-Gly-NH2 + H2O
(7-aminocoumarin-4-yl)acetyl-Gly-Phe(F)5-Tle-Pro-Phe + norvaline-Asp-Met(O)2-Gly-Lys(DNP)-Gly-NH2
-
-
-
-
?
4-(((S)-3-methyl-1-((S)-2-(((S)-1-((4-nitrophenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxobutan-2-yl)amino)-4-oxobutanoic acid + H2O
?
-
-
-
-
?
4-carboxybutyryl-Phe-2-naphthyl ester + H2O
4-carboxybutyryrl-Phe + 2-naphthol
-
-
-
ir
7-methoxycoumarin-4-yl-acetyl-Phe-Val-Thr-(4-guanidine-L-phenylalanyl)-amino benzoyl-NH2 + H2O
?
-
-
-
-
?
7-methoxycoumarin-4-yl-acetyl-Phe-Val-Thr-(4-guanidine-L-phenylalanyl)-Ser-amino benzoyl-NH2 + H2O
?
-
-
-
-
?
7-methoxycoumarin-4-yl-acetyl-Phe-Val-Thr-(4-guanidine-L-phenylalanyl)-Ser-Asp-amino benzoyl-NH2 + H2O
?
-
-
-
-
?
7-methoxycoumarin-4-yl-acetyl-Phe-Val-Thr-(4-guanidine-L-phenylalanyl)-Ser-Phe-amino benzoyl-NH2 + H2O
?
-
-
-
-
?
7-methoxycoumarin-4-yl-acetyl-Phe-Val-Thr-(4-guanidine-L-phenylalanyl)-Ser-Trp-amino benzoyl-NH2 + H2O
?
-
-
-
-
?
Abz-APEEIMRRQ-EDDnp + H2O
Abz-APEEI + MRRQ-EDDnp
-
-
-
-
?
Abz-VADnVRDRQ-EDDnp + H2O
Abz-VADnVR + DRQ-EDDnp
-
-
-
-
?
Ac-L-Phe-L-Val-L-Thr-(4-amino-L-phenylalanyl)-NH-(3-carbamoyl-4-nitrophenol) + H2O
Ac-L-Phe-L-Val-L-Thr-4-amino-L-phenylalanine + 5-amino-2-nitrobenzamide
-
-
-
-
?
Ac-L-Phe-L-Val-L-Thr-(4-carboxy-L-phenylalanyl)-NH-(3-carbamoyl-4-nitrophenol) + H2O
Ac-L-Phe-L-Val-L-Thr-4-carboxy-L-phenylalanine + 5-amino-2-nitrobenzamide
-
-
-
-
?
Ac-L-Phe-L-Val-L-Thr-(4-COOCH3-L-phenylalanyl)-NH-(3-carbamoyl-4-nitrophenol) + H2O
Ac-L-Phe-L-Val-L-Thr-4-COOCH3-L-phenylalanine + 5-amino-2-nitrobenzamide
-
-
-
-
?
Ac-L-Phe-L-Val-L-Thr-(4-cyano-L-phenylalanyl)-NH-(3-carbamoyl-4-nitrophenol) + H2O
Ac-L-Phe-L-Val-L-Thr-4-cyano-L-phenylalanine + 5-amino-2-nitrobenzamide
-
-
-
-
?
Ac-L-Phe-L-Val-L-Thr-(4-guanidyl-L-phenylalanyl)-NH-(3-carbamoyl-4-nitrophenol) + H2O
Ac-L-Phe-L-Val-L-Thr-4-guanidyl-L-phenylalanine + 5-amino-2-nitrobenzamide
-
-
-
-
?
Ac-L-Phe-L-Val-L-Thr-(4-nitro-L-phenylalanyl)-NH-(3-carbamoyl-4-nitrophenol) + H2O
Ac-L-Phe-L-Val-L-Thr-4-nitro-L-phenylalanine + 5-amino-2-nitrobenzamide
-
-
-
-
?
Ac-L-Phe-L-Val-L-Thr-L-Arg-NH-(3-carbamoyl-4-nitrophenol) + H2O
Ac-L-Phe-L-Val-L-Thr-L-Arg + 5-amino-2-nitrobenzamide
-
-
-
-
?
Ac-L-Phe-L-Val-L-Thr-L-Lys-NH-(3-carbamoyl-4-nitrophenol) + H2O
Ac-L-Phe-L-Val-L-Thr-L-Lys + 5-amino-2-nitrobenzamide
-
-
-
-
?
Ac-L-Phe-L-Val-L-Thr-L-Phe-NH-(3-carbamoyl-4-nitrophenol) + H2O
Ac-L-Phe-L-Val-L-Thr-L-Phe + 5-amino-2-nitrobenzamide
-
-
-
-
?
Ac-L-Phe-L-Val-L-Thr-L-Tyr-NH-(3-carbamoyl-4-nitrophenol) + H2O
Ac-L-Phe-L-Val-L-Thr-L-Tyr + 5-amino-2-nitrobenzamide
-
-
-
-
?
acetyl-Phe-Val-Thr-(4-guanidine-L-phenylalanyl)-amino benzoyl-NH2 + H2O
?
-
chromogenic cathepsin G substrate
-
-
?
CD40L + H2O
?
-
low activity
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
-
-
-
?
Elastin + H2O
Fragments of elastin
-
-
-
-
?
factor IX + H2O
?
-
-
-
-
?
factor VII + H2O
?
-
-
-
-
?
factor VIII + H2O
factor VIIIa + peptide
factor VIIIa + H2O
factor VIII + peptide
Fibronectin + H2O
?
-
hydrolysis after methionine, leucine, phenylalanine, lysine, or arginine residues
-
?
fibronectin + H2O
fragments of fibronectin
fibronectin + H2O
peptide fragments
glycoprotein Ibalpha subunit + H2O
?
-
from the glycoprotein Ib-IX receptor of human platelets
-
-
?
hemagglutinin + H2O
?
-
assay at pH 5.0, 37°C
-
-
?
high molecular mass kininogen + H2O
peptide fragments
-
human, 120 kDa
after 1 min reaction: 110, 100, and 75 kDa fragments, after 5 min reaction: 10 to 70 kDa fragments, after 60 min: less than 20 kDa fragments
?
human brm protein + H2O
160 kDa fragment of brm protein + 20 kDa fragment of brm protein
human recombinant B-cell activating factor + H2O
?
-
low activity
-
-
?
intercellular adhesion molecule-1 + H2O
fragments
interleukin-15 + H2O
?
-
-
-
-
?
interleukin-17A + H2O
?
-
low activity
-
-
?
interleukin-18 + H2O
?
-
-
-
-
?
interleukin-2 + H2O
?
-
low activity
-
-
?
interleukin-21 + H2O
?
-
low activity
-
-
?
interleukin-22 + H2O
?
-
low activity
-
-
?
interleukin-24 + H2O
?
-
low activity
-
-
?
interleukin-3 + H2O
?
-
-
-
-
?
interleukin-31 + H2O
?
-
efficient substrate
-
-
?
interleukin-33 + H2O
?
-
-
-
-
?
interleukin-36gamma + H2O
?
-
-
-
-
?
interleukin-6 + H2O
?
-
efficient substrate
-
-
?
interleukin-7 + H2O
?
-
efficient substrate
-
-
?
Laminin + H2O
?
-
hydrolysis after methionine, leucine, phenylalanine, lysine, or arginine residues
-
?
laminin + H2O
fragments of laminin
MARS123 + H2O
?
-
i.e. bis(4-methoxyphenyl) (1-((S)-1-((5-((3aS,4S,6aR)-3a,6a-dimethyl-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)-L-valyl)pyrrolidine-2-carboxamido)-3-methylbutyl)phosphonate. The reaction occurs in the presence of lactoferrin only
-
-
?
MARS125 + H2O
?
-
i.e. diphenyl(1-((S)-1-((5-((3aS,4S,6aR)-3a,6adimethyl-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)-L-valyl)pyrrolidine-2-carboxamido)-2-methylpropyl)phosphonate. The reaction occurs in the presence of lactoferrin only
-
-
?
membrane-bound stem cell factor + H2O
?
-
-
-
-
?
methoxy succinyl-L-alanine-L-alanine-L-proline-L-valine-p-nitroanilide + H2O
?
-
-
-
-
?
myelin basic protein + H2O
myelin basic protein peptide fragments
N-acetyl-L-Phe-p-nitrophenyl ester + H2O
?
-
-
-
-
?
N-acetyl-L-phenylalanyl-L-valyl-L-threonyl-N-(5-amino-2-nitrobenzoyl)-3-pyridin-4-yl-L-alaninamide) + H2O
N-acetyl-L-phenylalanyl-L-valyl-L-threonyl-3-pyridin-4-yl-L-alanine + 5-amino-2-nitrobenzamide
-
-
-
-
?
N-benzoyl-L-Tyr ethyl ester + H2O
N-benzoyl-L-Tyr + ethanol
-
-
-
-
?
N-benzoyl-L-tyrosine ethyl ester + H2O
N-benzoyl-L-tyrosine + ethanol
-
-
-
-
?
N-carbobenzyloxy-L-Lys-thiobenzylester + H2O
?
-
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + p-nitroaniline
N-succinyl-Ala-Ala-Pro-Phe-thiobenzyl ester + H2O
?
-
chromogenic substrate
-
?
N-succinyl-L-Phe-L-Pro-L-Phe-4-nitroanilide + H2O
N-succinyl-L-Phe-L-Pro-L-Phe + 4-nitroaniline
-
-
-
-
?
N-succinyl-L-Val-L-Pro-L-Phe-4-nitroanilide + H2O
N-succinyl-L-Val-L-Pro-L-Phe + 4-nitroaniline
-
-
-
-
?
N-succinyl-Phe-Leu-Phe-thiobenzyl ester + H2O
?
-
chromogenic substrate
-
?
protease-activated receptor-1 + H2O
?
-
i.e. PAR1, activation of platelets by hydrolysis of the receptor protein
-
?
protease-activated receptor-4 + H2O
?
-
i.e. PAR4, activation of platelets by hydrolysis of the receptor protein
-
?
RANTES 1-68 + H2O
RANTES 4-68 + peptide
succinyl-AAPF-4-nitroanilide + H2O
succinyl-AAPF + 4-nitroaniline
-
-
-
-
?
succinyl-AAPL-4-nitroanilide + H2O
succinyl-AAPL + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Phe-p-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
?
succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe-thiobenzyl ester + H2O
?
-
-
-
ir
succinyl-LLVY-4-nitroanilide + H2O
succinyl-LLVY + 4-nitroaniline
-
-
-
-
?
succinyl-Phe-Leu-Phe-thiobenzyl ester + H2O
?
-
-
-
-
?
tetanus toxin C-fragment + H2O
?
-
assay at pH 5.0, 37°C
-
-
?
thrombospondin + H2O
peptide fragments
von Willebrand factor + H2O
peptide fragments
additional information
?
-
cadherin + H2O
?
-
-
-
?
cadherin + H2O
?
-
-
-
-
?
factor VIII + H2O
factor VIIIa + peptide
-
cathepsin G activates coagulation factor VIII to apartially active form, while having only a minor inactivating effect on thrombin-activated factor VIIIa, overview
-
-
?
factor VIII + H2O
factor VIIIa + peptide
-
cleavage releases the bound von-Willebrand factor and the corresponding peptide sequence, determination of cleavage sites, overview
-
-
?
factor VIIIa + H2O
factor VIII + peptide
-
-
-
-
?
factor VIIIa + H2O
factor VIII + peptide
-
cathepsin G activates coagulation factor VIII to apartially active form, while having only a minor inactivating effect on thrombin-activated factor VIIIa, inactivation occurs due to decreased stability by subsequent dissociation of the A2 subunit following proteolytic cleavage by cathepsin G, overview
-
-
?
fibronectin + H2O
fragments of fibronectin
-
-
-
-
?
fibronectin + H2O
fragments of fibronectin
-
-
-
ir
fibronectin + H2O
fragments of fibronectin
-
degradation, involved in inflammation process
-
ir
fibronectin + H2O
peptide fragments
-
220 kDa substrate in extracellular matrix of human umbilical vein endothelial cells and platelets
162 kDa, 122 kDa, and 92 kDa
?
fibronectin + H2O
peptide fragments
-
proteolysis causes no change in endothelial cell morphology, involved in release of extracellular matrix components during inflammation
-
?
human brm protein + H2O
160 kDa fragment of brm protein + 20 kDa fragment of brm protein
-
i.e. hbrm, cleavage in vitro after induction of apoptosis, cleavage pattern
the 20 kDa fragment contains a bromodomain from the C-terminus of hbrm, the 160 kDa binds less tightly to he nuclear matrix than the full length protein
?
human brm protein + H2O
160 kDa fragment of brm protein + 20 kDa fragment of brm protein
-
i.e. hbrm, nuclear protein in volved in regulation of chromatin conformation
-
?
intercellular adhesion molecule-1 + H2O
fragments
-
i.e. ICAM-1, a membrane glycoprotein consisting of five extracellular Ig-like domains, a transmembrane domain, and a short cytoplasmic tail, all alternate substrate isoforms or mutant substrate forms but the common form, from mouse and human, substrate specificity is influenced by the ability of the ICAM-1 isoforms to form dimers and larger multimeric complexes
-
?
intercellular adhesion molecule-1 + H2O
fragments
-
i.e. ICAM-1, the substrate plays an important role in inflammation and immune response, e.g. to sustain neutrophil infiltration and to confer susceptibility to septic shock, all alternate substrate isoforms but the common form, in model mouse mutants, and in cystic fibrosis patients
-
?
laminin + H2O
fragments of laminin
-
-
-
?
laminin + H2O
fragments of laminin
-
degradation, involved in inflammation process
-
ir
MARS116 + H2O
?
-
i.e. Bt-LC-Suc-Val-Pro-PheP(OPh)2
-
-
?
MARS116 + H2O
?
-
i.e. diphenyl(1-((S)-1-((4-oxo-4-((5-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)pentyl)amino)butanoyl)-L-valyl)pyrrolidine-2-carboxamido)-2-phenylethyl)phosphonate. The reaction occurs in the presence of lactoferrin only
-
-
?
myelin basic protein + H2O
myelin basic protein peptide fragments
-
-
-
-
?
myelin basic protein + H2O
myelin basic protein peptide fragments
-
the serine protease cathepsin G dominates the proteolytic processing of the multiple sclerosis-associated autoantigen myelin basic protein in lysosomes from primary B cells and dendritic cells, overview
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
chromogenic substrate
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
chromogenic substrate
-
?
N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + p-nitroaniline
-
assay at pH 7.5, 37°C
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + p-nitroaniline
-
assay at 37°C
-
-
?
RANTES 1-68 + H2O
RANTES 4-68 + peptide
-
cell-associated N-terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4-68 variant
-
-
?
RANTES 1-68 + H2O
RANTES 4-68 + peptide
-
N-terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4-68 variant
-
-
?
thrombospondin + H2O
peptide fragments
-
preferred substrate, 180 kDa substrate in extracellular matrix of human umbilical vein endothelial cells and platelets
155 kDa and 25 kDa
?
thrombospondin + H2O
peptide fragments
-
proteolysis causes no change in endothelial cell morphology, involved in release of extracellular matrix components during inflammation
-
?
von Willebrand factor + H2O
peptide fragments
-
280 kDa substrate in extracellular matrix of human umbilical vein endothelial cells and platelets
260-177 kDa and 177-136 kDa
?
von Willebrand factor + H2O
peptide fragments
-
proteolysis causes no change in endothelial cell morphology, involved in release of extracellular matrix components during inflammation
-
?
additional information
?
-
the enzyme is one of the major components of the neutrophil primary granules that participate in the non-oxidative pathway of intracellular pathogen destruction, it helps kill bacterial cells and is involved in the degradation of extracellular matrix components during acute and chronic inflammation, the enzyme is important in regulation of immune response, control of cellular signaling through the procession of cytokines and modulation of the cytokine network, biological functions and roles in diseases of cathepsin G, overview
-
-
?
additional information
?
-
-
the enzyme is one of the major components of the neutrophil primary granules that participate in the non-oxidative pathway of intracellular pathogen destruction, it helps kill bacterial cells and is involved in the degradation of extracellular matrix components during acute and chronic inflammation, the enzyme is important in regulation of immune response, control of cellular signaling through the procession of cytokines and modulation of the cytokine network, biological functions and roles in diseases of cathepsin G, overview
-
-
?
additional information
?
-
cathepsin G prefers aromatic or positively charged residues at P1 position, e.g. Phe, Tyr, Lys, or Arg, substrate specificity and active site structure analysis, overview
-
-
?
additional information
?
-
-
cathepsin G prefers aromatic or positively charged residues at P1 position, e.g. Phe, Tyr, Lys, or Arg, substrate specificity and active site structure analysis, overview
-
-
?
additional information
?
-
the enzyme does not hydrolyze high-density lipoprotein
-
-
?
additional information
?
-
-
the enzyme does not hydrolyze high-density lipoprotein
-
-
?
additional information
?
-
-
no activity with PAR1-mutant A2F and PAR4 mutant G1P
-
?
additional information
?
-
-
enzyme causes platelet secretion and aggregation mediated by protease-activated receptor-4, i.e. PAR4, triggers calcium mobilization in PAR4-transfected fibroblasts, PAR4-expressing Xenopus oocytes, and washed human platelets, enzyme might mediate platelet-neutrophil interaction at sites of vascular injury or inflammation, regulation of enzyme activity on platelets and protease-activated receptors-1 and -4
-
?
additional information
?
-
-
enzyme is involved in pathological processes of inflammation
-
?
additional information
?
-
-
the enzyme can directly alter platelet function and/or participate in coagulation cascade reactions on the platelet or neutrophil surface to enhance fibrin formation, coagulation pathway overview
-
?
additional information
?
-
-
the enzyme induces cell proliferation, cytokine productionand IFN-gamma production in normal spleen cells and T lymphocytes from mice
-
?
additional information
?
-
-
the enzyme induces chemotaxis and production of proinflammatory cytokines by macrophages but not by CD4+ T cells, pretreatment of macrophages, but not CD4+ T cells, increases susceptibility to acute HIV-infection, the enzyme has mutiple activities in HIV-type1 infection of macrophages, long-term exposure to cathepsin G suppresses HIV infection of macrophages, the effect is neutralized by serine protease inhibitors
-
?
additional information
?
-
-
the enzyme probably represents an alternative pathway that modulates the expression of intercellular adhesion molecule-1 on the cell surface
-
?
additional information
?
-
-
cathepsin G and neutrophil elastase are involved in responses of polymorphonucleocytes to various stimuli. When released at sites of inflammation, they participate in the degradation of numerous proteins involved in the regulation of the immune response. the ability of cathepsin G and neutrophil elastase to modulate levels of membrane and soluble forms of tumor necrosis factor alpha may contribute to the proinflammatory activity of neutrophils
-
-
?
additional information
?
-
-
cathepsin G controls the processing of myelin basic protein in lysosomes from human B lymphocytes
-
-
?
additional information
?
-
-
cathepsin G regulates adhesion-dependent neutrophil effector functions by modulating integrin clustering
-
-
?
additional information
?
-
-
hypochlorous acid, a specific product of myeloperoxidase, potently inactivates cathepsin G by a pathway that involves oxidation of a specific methionine residue, which in turn may disrupt the catalytic charge relay system and introduce proteolytic cleavage sites into the enzyme. This finding raises the possibility that myeloperoxidase might restrain the activity of cathepsin G near the surface of neutrophils
-
-
?
additional information
?
-
-
in stenotic aortic valves, mast cell-derived cathepsin G may cause adverse valve remodelling and progression of aortic stenosis
-
-
?
additional information
?
-
-
Mycobacterium tuberculosis infection results in a cathepsin switch with down-regulation of cathepsin G rendering Mycobacterium tuberculosis bacilli more viable. Downregulation of cathepsin G in macrophages is advantageous to Mycobacterium tuberculosis bacilli and possibly is an important mechanism by which Mycobacterium tuberculosis is able to evade the host immune defense
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-
?
additional information
?
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-
neutrophil elastase and cathepsin G induce the formation of highly aggregated multicellular 3-D spheroids of MCF-7 cells. Neutrophil elastase and cathepsin G might be involved in the dissemination of tumor clumps and formation of emboli in tumor metastasis
-
-
?
additional information
?
-
-
release of leukocyte elastase or cathepsin G from neutrophils specifically down-regulates the responsiveness of neutrophils to C5a. Elastase and cathepsin G may therefore play an important role in the down-regulation of acute inflammation
-
-
?
additional information
?
-
-
the enzyme is a chemotactic agonist for G protein-coupled formyl peptide receptor
-
-
?
additional information
?
-
-
cathepsin G acts as a monocyte chemoattractant in rheumatoid arthritis inducing monocyte migration, overview
-
-
?
additional information
?
-
-
specificity with synthetic fluorogenic/chromogenic substrates, preference for aromatic residues at P1 position, specificity at other positions, overview
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-
?
additional information
?
-
-
specificity with synthetic fluorogenic/chromogenic substrates, the enzyme prefers Ser at P1' position and Trp at the P2' position, overview
-
-
?
additional information
?
-
-
cathepsin G shows a concentration-dependent induction of monocyte chemotaxis. At the highest concentrations, it induced chemotaxis similar to MCP-1, a known monocyte chemoattractant
-
-
?
additional information
?
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-
human cathepsin G has broad chymotryptic activity, cleaving after Trp, Phe, and Tyr, with little preference for Tyr versus Phe. It also has substantial Leu-ase and Met-ase activity, with little or no ability to cleave after P1 acidic residues (granzyme B-like Asp-ase activity) and small aliphatic residues (neutrophil elastase-like activity). Its most unique feature, however, is tryptic activity, which is as strong as its Tyr-cleaving chymotryptic activity and is largely Lys-specific
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-
?
additional information
?
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-
The enzyme has a dual specificity consisting of chymase and tryptase-type activities. Phe, Tyr, Trp and Leu are preferred in the P1 position. The enzyme has a preference for negatively charged amino acids in the P2A position of substrates and a preference for aliphatic amino acids both upstream and downstream of the cleavage site
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?
additional information
?
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-
the extended cleavage sites for the enzyme contain about 8 amino acids, and cleavage normally occurs after an aromatic amino acid (phenylalanine, tyrosine and tryptophan or leucine) in the P1 substrate position
-
-
?
additional information
?
-
-
lactoferrin is not proteolytically degraded by the enzyme
-
-
?
additional information
?
-
-
no activity with interleukin-4, interleukin-5, or interleukin-10
-
-
?
additional information
?
-
-
no activity with succinyl-AAPI-4-nitroanilide, succinyl-AAPA-4-nitroanilide, succinyl-AAPV-4-nitroanilide, succinyl-VLGR-4-nitroanilide, Z-GPR-4-nitroanilide, acetyl-YVAD-4-nitroanilide, acetyl-VEID-4-nitroanilide, and acetyl-IEPD-4-nitroanilide
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?
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11-oxo-beta-boswellic acid
0.01 mM, 30% cathepsin G activity compared to control
3-O-acetyl-11-oxo-beta-boswellic acid
0.01 mM, 15% cathepsin G activity compared to control
3-O-acetyl-beta-boswellic acid
0.01 mM, 5% cathepsin G activity compared to control
alpha1-Aantichymotrypsin
-
-
alpha1-protease inhibitor
-
-
beta-boswellic acid
0.01 mM, 30% cathepsin G activity compared to control
cathepsin G inhibitor I
-
glut-11-oxo-beta-boswellic acid
0.01 mM 20% cathepsin G activity compared to control
JNJ-10311795
inhibitor of cathepsin G and chymase. The possibility to inhibit both cathepsin G and chymase with a single molecule suggests an opportunity in the treatment of asthma and chronic obstructive pulmonary disease
monocyte neutrophil elastase inhibitor
-
-
N-succinyl-L-Ala-L-Ala-L-Pro-L-Phe-chloromethylketone
irreversible inhibitor
N-succinyl-L-Val-L-Pro-L-Phe-(OPh)2
irreversible inhibitor
protease inhibitor PI6
-
-
secretory leukocyteprotease inhibitor
-
-
squamous cell carcinoma antigen 2
-
-
ursolic acid
0.01 mM, 80% cathepsin G activity compared to control
[2-(3-[methyl[1-(2-naphthoyl)piperidin-4-yl]amino]carbonyl]-2-naphthyl)-1-(1-naphthyl)-2-oxoethyl]phosphonic acid
0.0005 mM, 10% cathepsin G activity compared to control
2-(N-methyl)benzylamino-3,1-benzoxazin-4-one
-
strongest inhibition
2-amino-3,1-benzoxazin-4-ones
-
non-covalent complex formation, hydrophobic and basic residues at position 2, kinetics of acylation and desacylation, binding at the enzyme's active site
4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride
-
-
6-((1'R)-camphanyl)amino-2-[(ethylsulfonyl)oxy]-1H-isoindole-1,3-dione
-
-
6-((1'R,2'S,5'R)-menthyloxycarbonyl)amino-2-[(ethylsulfonyl)oxy]-1H-isoindole-1,3-dione
-
-
6-((1'S)-camphanyl)amino-2-[(ethylsulfonyl)oxy]-1H-isoindole-1,3-dione
-
selective inhibition
6-((1'S,2'R,5'S)-menthyloxycarbonyl)amino-2-[(ethylsulfonyl)oxy]-1H-isoindole-1,3-dione
-
-
6-(benzoyl)amino-2-[(ethylsulfonyl)oxy]-1H-isoindole-1,3-dione
-
selective inhibition
6-(N-tosyl-L-phenylalanyl)amino-2-[(ethylsulfonyl)oxy]-1H-isoindole-1,3-dione
-
-
6-(N-tosyl-L-valinyl)amino-2-[(ethylsulfonyl)oxy]-1H-isoindole-1,3-dione
-
-
alpha-1 proteinase inhibitor
-
-
-
alpha-1-antichymotrypsin
-
-
-
alpha1-Aantichymotrypsin
-
Alpha1-proteinase inhibitor
-
-
-
alpha2-Macroglobulin
-
-
-
aspartyl protease inhibitor pepstatin
-
-
-
benzyloxycarbonyl-Gly-Leu-Phe-chloromethyl ketone
bis(4-ethylphenyl) [[[(benzyloxy)carbonyl]amino](4-carbamimidamidophenyl)methyl]phosphonate
-
-
bis(4-methoxyphenyl) [[[(benzyloxy)carbonyl]amino](4-carbamimidamidophenyl)methyl]phosphonate
-
more potent inhibitor for related proteases than cathepsin G
bis(4-methylphenyl) [[[(benzyloxy)carbonyl]amino](4-carbamimidamidophenyl)methyl]phosphonate
-
-
bis(4-tert-butylphenyl) [[[(benzyloxy)carbonyl]amino](4-carbamimidamidophenyl)methyl]phosphonate
-
-
bis-naphthyl beta-ketophosphoric acid
-
moderately potent, competitive, reversible, the R-isomer occupies the active site of the enzyme
bis[4-(1,1,3,3-tetramethylbutyl)phenyl] [[[(benzyloxy)carbonyl]amino](4-carbamimidamidophenyl)methyl]phosphonate
-
3% inhibition, 115 microM
bis[4-(1-methylethyl)phenyl] [[[(benzyloxy)carbonyl]amino](4-carbamimidamidophenyl)methyl]phosphonate
-
-
bis[4-(methylsulfanyl)phenyl] ([4-[bis(tert-butoxycarbonyl)carbamimidamido]phenyl][(O-tert-butyl-L-threonyl)amino]methyl)phosphonate
-
-
bis[4-(methylsulfanyl)phenyl] [[4-[bis(tert-butoxycarbonyl)carbamimidamido]phenyl]([O-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-threonyl]amino)methyl]phosphonate
-
-
bis[4-(methylsulfanyl)phenyl] [[[(benzyloxy)carbonyl]amino](4-carbamimidamidophenyl)methyl]phosphonate
-
more potent inhibitor for related proteases than cathepsin G
CatG-specific inhibitor I
-
reversible inhibitor
-
cathepsin G inhibitor I
-
-
-
chymotrypsin inhibitor 1
-
Apis mellifera
-
chymotrypsin inhibitor 2
-
Apis mellifera
-
chymotrypsin inhibitor 3
-
Apis mellifera
-
cysteine protease inhibitor E64
-
-
dermatan sulfate
-
25 kDa, protection of laminin and fibronectin against degradation by cathepsin G
diethyl 1-naphthylmethylphosphonate
-
-
diisopropylfluorophosphate
-
-
dinaphthalen-2-yl [[[(benzyloxy)carbonyl]amino](4-carbamimidamidophenyl)methyl]phosphonate
-
-
diphenyl (1-[[(benzyloxy)carbonyl]amino]-3-carbamimidamidopropyl)phosphonate
-
-
diphenyl (4-amino-1-[[(benzyloxy)carbonyl]amino]butyl)phosphonate
-
5% inhibition, 221 microM
diphenyl [(4-aminophenyl)[[(benzyloxy)carbonyl]amino]methyl]phosphonate
-
-
diphenyl [[[(benzyloxy)carbonyl]amino](4-carbamimidamidophenyl)methyl]phosphonate
-
more potent inhibitor for related proteases than cathepsin G
diphenyl [[[(benzyloxy)carbonyl]amino](4-carbamimidoylphenyl)methyl]phosphonate
-
30% inhibition, 112 microM
diphenyl [[[(benzyloxy)carbonyl]amino](6-carbamimidoylnaphthalen-2-yl)methyl]phosphonate
-
5% inhibition, 112 microM
diphenyl [[[(benzyloxy)carbonyl]amino](phenyl)methyl]phosphonate
-
more potent inhibitor for related proteases than cathepsin G
heparan sulfate
-
60 kDa, protection of laminin and fibronectin against degradation by cathepsin G
heparin
-
12 kDa, 1:1 binding stoichiometry with cathepsin G, protection of laminin and fibronectin against degradation by cathepsin G
high molecular mass kininogen
-
i.e. HK, human, competitive, inhibits platelet activation by the enzyme completely by complex formation with the enzyme
-
L-1-tosylamido-2-phenylethyl chloromethyl ketone
-
weak inhibition
L-valyl-N-([4-[bis(tert-butoxycarbonyl)carbamimidamido]phenyl][bis[4-(methylsulfanyl)phenoxy]phosphoryl]methyl)-O-tert-butyl-L-threoninamide
-
-
L-valyl-N-[[bis[4-(methylsulfanyl)phenoxy]phosphoryl](4-carbamimidamidophenyl)methyl]-L-threoninamide
-
-
mutant R346F of plasminogen activator inhibitor-1
-
-
-
N-acetyl-L-phenylalanyl-L-valyl-N-([4-[bis(tert-butoxycarbonyl)carbamimidamido]phenyl][bis[4-(methylsulfanyl)phenoxy]phosphoryl]methyl)-O-tert-butyl-L-threoninamide
-
-
N-acetyl-L-phenylalanyl-L-valyl-N-[[bis[4-(methylsulfanyl)phenoxy]phosphoryl](4-carbamimidamidophenyl)methyl]-L-threoninamide
-
-
N-tosyl-L-phenylalanine chloromethyl ketone
-
TPCK, inhibitor of the proteolytic activity of cathepsin G, effectively eliminated cathepsin G-induced chemotaxis of monocytes
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N-([4-[bis(tert-butoxycarbonyl)carbamimidamido]phenyl][bis[4-(methylsulfanyl)phenoxy]phosphoryl]methyl)-O-tert-butyl-L-threoninamide
-
-
N-[[bis[4-(methylsulfanyl)phenoxy]phosphoryl](4-carbamimidamidophenyl)methyl]-L-threoninamide
-
two times more active against cathepsin G than against trypsin
pepstatin A-penetratin
-
-
-
phenylmethylsulfonyl fluoride
-
-
plasma serine protease inhibitor ACT
-
-
-
RG1150
-
i.e. carboxymethyl-benzylamide-dextran derivative, protection of laminin and fibronectin against degradation by cathepsin G
-
RG1192
-
i.e. carboxymethyl-benzylamide-dextran sulfate derivative, protection of laminin and fibronectin against degradation by cathepsin G
-
RG1503
-
i.e. carboxymethyl-dextran sulfate derivative, protection of laminin and fibronectin against degradation by cathepsin G
-
Soybean trypsin inhibitor
-
-
-
specific Cat-G inhibitor
-
1 microM, decrease of enzyme activity by 43%
-
tosylphenylalanyl chloromethane
-
-
[2-(3-methylcarbamoyl-naphthalen-2-yl)-1-naphthalen-1-yl-2-oxo-ethyl]-phosphonic acid
-
-
[2-(3-[(3-benzoylamino-propyl)-methyl-carbamoyl]-naphthalen-2-yl)-1-naphthalen-1-yl-2-oxo-ethyl]-phosphonic acid
-
-
[2-(3-[(piperidin-4-yl)-methyl-carbamoyl]-naphthalen-2-yl)-1-naphthalen-1-yl-2-oxo-ethyl]-phosphonic acid
-
reversible, selective, competitive inhibition
[2-(3-[methyl-(diphenyl-ethylcarbamoyl-methyl)-carbamoyl]-naphthalen-2-yl)-1-naphthalen-1-yl-2-oxo-ethyl]-phosphonic acid
-
strong inhibition
[2-(3-[methyl-(phenethylcarbamoyl-methyl)-carbamoyl]-naphthalen-2-yl)-1-naphthalen-1-yl-2-oxo-ethyl]-phosphonic acid
-
-
[2-[3-(benzyl-methyl-carbamoyl)-naphthalen-2-yl]-1-naphthalen-1-yl-2-oxo-ethyl]-phosphonic acid
-
-
[Nphe,Npip,Nleu]SFTI-1
-
0.1 mM
[Phe(4-guanidine)]SFTI-1
-
0.1 mM
cathepsin G inhibitor I
-
-
cathepsin G inhibitor I
-
-
-
alpha1-Aantichymotrypsin
-
-
-
alpha1-Aantichymotrypsin
-
acute phase reactant which is up-regulated during inflammation episodes to compensate for the excess of enzymes released from the actvated neutrophils
-
benzyloxycarbonyl-Gly-Leu-Phe-chloromethyl ketone
-
-
benzyloxycarbonyl-Gly-Leu-Phe-chloromethyl ketone
-
i.e. CK-08, specific for cathepsin G
PMSF
-
-
PMSF
-
97% inactivation at 0.02 mM in isopropanol, 22°C, reversible
additional information
inhibition mechanisms, overview
-
additional information
-
inhibition mechanisms, overview
-
additional information
-
-
-
additional information
-
-
-
additional information
-
kinetic mechanism of inhibition
-
additional information
-
kinetic mechanism of inhibition
-
additional information
-
kinetic mechanism of inhibition
-
additional information
-
5kD heparin fragment protects against inhibition by alpha1-antichymotrypsin inhibitor, eglin c and alpha1-proteinase inhibitor
-
additional information
-
inhibitors from soybean and lima-bean
-
additional information
-
inhibitors from soybean and lima-bean
-
additional information
-
inhibitors from soybean and lima-bean
-
additional information
-
sulfonate and phosphate esters
-
additional information
-
inhibition mechanism and kinetics, effect of ionic strength
-
additional information
-
structural features of inhibition, high-throughput screening of a diverse chemical library, lead structure is bis-naphthyl beta-ketophosphoric acid
-
additional information
-
no inhibition by plasminogen activator inhibitor-1
-
additional information
-
no inhibition by von-Willebrand factor
-
additional information
-
no inhibitory effect: diphenyl (1-[[(benzyloxy)carbonyl]amino]-4-carbamimidamidobutyl)phosphonate
-
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Abscess
Histochemical localization of neutral proteases released during development of rat periradicular lesion.
Acromegaly
Human nasal septal cartilage: analysis of intracellular enzyme activities, glycogen content, cell density and clonal proliferation of septal chondrocytes of healthy adults and acromegalic patients.
Acromegaly
Human nasal septal cartilage: local distribution of different enzyme activities in healthy adults and acromegalic patients.
Acute Lung Injury
IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G.
Acute Lung Injury
Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema.
Adenocarcinoma
Activity and tissue localization of cathepsin G in non small cell lung cancer.
Aggressive Periodontitis
Neutrophil lysosomal nonoxidative microbicidal proteins in early-onset periodontitis.
Albuminuria
Antiglomerular basement membrane nephritis in beige mice. Deficiency of leukocytic neutral proteinases prevents the induction of albuminuria in the heterologous phase.
Albuminuria
Different mediator systems in biphasic heterologous phase of anti-GBM nephritis in mice.
Albuminuria
Lack of albuminuria in the early heterologous phase of anti-GBM nephritis in beige mice.
Alzheimer Disease
Cathepsin G: localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein.
Alzheimer Disease
Enzymatic generation of the amino terminus of the beta-amyloid peptide.
Alzheimer Disease
Genetic polymorphism in the cathepsin G gene and the risk of Alzheimer's disease.
Alzheimer Disease
Mutation of the gene for the human lysosomal serine protease cathepsin G is not the cause of aberrant APP processing in familial Alzheimer disease.
Amyloidosis
Neutrophil proteases associated with amyloid fibrils.
Anaphylaxis
Postmortem detection of antibiotic-specific immunoglobulin E in the case of anaphylactic death.
Anti-Glomerular Basement Membrane Disease
The isolation of a neutral proteinase from the urine of a patient with Goodpasture's Syndrome.
Aortic Aneurysm
Activities of proteases in parietal thrombus of aortic aneurysm.
Aortic Aneurysm, Abdominal
Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice.
Arthritis
Antigen induced arthritis in beige (Chediak-Higashi) mice.
Arthritis
Cathepsin G and elastase in synovial fluid and peripheral blood in reactive and rheumatoid arthritis.
Arthritis
Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic arthritis by cathepsin G and elastase from polymorphonuclear leukocytes.
Arthritis
Human mononuclear cells and neutral proteinases. III. Neutral proteinases and rheumatoid arthritis: monocytes as a source of cathepsin G and proteinase potentiation of IgM rheumatoid factor elaboration.
Arthritis
Pathogenesis of antigen-induced arthritis in mice deficient in neutrophil elastase and cathepsin G.
Arthritis
Recombinant human interleukin-1 stimulates human articular cartilage to undergo resorption and human chondrocytes to produce both tissue- and urokinase-type plasminogen activator.
Arthritis, Experimental
Levels of collagenolytic activity, beta-glucuronidase, and collagen prolyl hydroxylase in paws from rats with developing adjuvant arthritis.
Arthritis, Juvenile
Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic arthritis by cathepsin G and elastase from polymorphonuclear leukocytes.
Arthritis, Rheumatoid
Antineutrophil cytoplasmic antibodies against myeloperoxidase, proteinase 3, elastase, cathepsin G and lactoferrin in Japanese patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Antineutrophil cytoplasmic antibodies in Bulgarian patients with rheumatoid arthritis: characterization and clinical associations.
Arthritis, Rheumatoid
Cathepsin G and elastase in synovial fluid and peripheral blood in reactive and rheumatoid arthritis.
Arthritis, Rheumatoid
Cathepsin G: the significance in rheumatoid arthritis as a monocyte chemoattractant.
Arthritis, Rheumatoid
Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic arthritis by cathepsin G and elastase from polymorphonuclear leukocytes.
Arthritis, Rheumatoid
Human leucocyte elastase and cathepsin G: structural and functional characteristics.
Arthritis, Rheumatoid
Human mononuclear cells and neutral proteinases. III. Neutral proteinases and rheumatoid arthritis: monocytes as a source of cathepsin G and proteinase potentiation of IgM rheumatoid factor elaboration.
Arthritis, Rheumatoid
Neutrophil elastase and cathepsin G: structure, function, and biological control.
Arthritis, Rheumatoid
Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.
Arthritis, Rheumatoid
Quantitation of human leukocyte elastase, cathepsin G, alpha-2-macroglobulin and alpha-1-proteinase inhibitor in osteoarthrosis and rheumatoid arthritis synovial fluids.
Arthritis, Rheumatoid
Quantitative analysis of elastase and cathepsin G mRNA levels in peripheral blood CD14(+) cells from patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium.
Arthritis, Rheumatoid
The inhibitory effects of antirheumatic drugs on the activity of human leukocyte elastase and cathepsin G.
Asthma
A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
Asthma
Dual Inhibition of Cathepsin G and Chymase is Effective in Animal Models of Pulmonary Inflammation.
Asthma
Systemic upregulation of neutrophil {alpha}-defensins and serine proteases in neutrophilic asthma.
Atherosclerosis
Cathepsin G activity lowers plasma LDL and reduces atherosclerosis.
Atherosclerosis
Cathepsin G deficiency decreases complexity of atherosclerotic lesions in apolipoprotein E-deficient mice.
Atherosclerosis
Human mast cell neutral proteases generate modified LDL particles with increased proteoglycan binding.
Autoimmune Diseases
Cathepsin G and Its Role in Inflammation and Autoimmune Diseases.
Bone Resorption
Bone health nutraceuticals alter microarray mRNA gene expression: A randomized, parallel, open-label clinical study.
Bone Resorption
Cathepsin G-mediated activation of pro-matrix metalloproteinase 9 at the tumor-bone interface promotes transforming growth factor-beta signaling and bone destruction.
Brain Injuries
Cathepsin g-dependent modulation of platelet thrombus formation in vivo by blood neutrophils.
Brain Ischemia
Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke.
Breast Neoplasms
Anti-IL-20 monoclonal antibody suppresses breast cancer progression and bone osteolysis in murine models.
Breast Neoplasms
Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand.
Breast Neoplasms
Cathepsin G Induces Cell Aggregation of Human Breast Cancer MCF-7 Cells via a 2-Step Mechanism: Catalytic Site-Independent Binding to the Cell Surface and Enzymatic Activity-Dependent Induction of the Cell Aggregation.
Breast Neoplasms
Cathepsin G, a neutrophil protease, induces compact cell-cell adhesion in MCF-7 human breast cancer cells.
Breast Neoplasms
Cathepsin G-Induced Insulin-Like Growth Factor (IGF) Elevation in MCF-7 Medium Is Caused by Proteolysis of IGF Binding Protein (IGFBP)-2 but Not of IGF-1.
Breast Neoplasms
Induction of multicellular 3-D spheroids of MCF-7 breast carcinoma cells by neutrophil-derived cathepsin G and elastase.
Breast Neoplasms
Insulin-like growth factor-1 signaling is responsible for cathepsin G-induced aggregation of breast cancer MCF-7 cells.
Breast Neoplasms
Neutrophil cathepsin G, but not elastase, induces aggregation of MCF-7 mammary carcinoma cells by a protease activity-dependent cell-oriented mechanism.
Breast Neoplasms
Role of promyelocytic leukemia (PML) protein in tumor suppression.
Bronchiectasis
Potentiative effects of neutral proteinases in an inflamed lung: relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo.
Bronchiectasis
Presence, activities, and molecular forms of cathepsin G, elastase, alpha 1-antitrypsin, and alpha 1-antichymotrypsin in bronchiectasis.
Bronchopulmonary Dysplasia
SERPINB1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia.
Carcinogenesis
Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation.
Carcinoma
Bioinformatics Analyses Indicate That Cathepsin G (CTSG) is a Potential Immune-Related Biomarker in Oral Squamous Cell Carcinoma (OSCC).
Carcinoma
Connective tissue degradation by invasive rat bladder carcinomas: action of nonspecific proteinases on collagenous matrices.
Carcinoma
Markedly elevated cell turnover is characteristic of small, deeply invasive carcinomas of the colorectum.
Carcinoma
Neutrophil cathepsin G, but not elastase, induces aggregation of MCF-7 mammary carcinoma cells by a protease activity-dependent cell-oriented mechanism.
Carcinoma
Proteoglycan- and fibrin-degrading neutral proteinase activities of Lewis lung carcinoma cells.
Carcinoma
Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase.
Carcinoma
Syndecans, heparan sulfate proteoglycans, maintain the proteolytic balance of acute wound fluids.
Carcinoma
Treponema denticola chymotrypsin-like proteinase is present in early-stage mobile tongue squamous cell carcinoma and related to the clinicopathological features.
Carcinoma
Tumor cell metastasis and surface neutral proteinase: effects of antimetastatic and antitumor drugs.
Carcinoma, Ehrlich Tumor
Purification and further characterization of the Ca2+-activated proteinase specific for the intermediate filament proteins vimentin and desmin.
Carcinoma, Hepatocellular
High-molecular-weight neutral proteinase of rat ascites hepatoma cells and their collagenolytic activity.
Carcinoma, Hepatocellular
The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target.
Carcinoma, Lewis Lung
Proteoglycan- and fibrin-degrading neutral proteinase activities of Lewis lung carcinoma cells.
Carcinoma, Lewis Lung
Tumor cell metastasis and surface neutral proteinase: effects of antimetastatic and antitumor drugs.
Carcinoma, Renal Cell
Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin.
Carcinoma, Squamous Cell
Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase.
Carcinoma, Squamous Cell
Syndecans, heparan sulfate proteoglycans, maintain the proteolytic balance of acute wound fluids.
Carcinoma, Squamous Cell
Treponema denticola chymotrypsin-like proteinase is present in early-stage mobile tongue squamous cell carcinoma and related to the clinicopathological features.
cathepsin g deficiency
Cathepsin G deficiency decreases complexity of atherosclerotic lesions in apolipoprotein E-deficient mice.
cathepsin g deficiency
Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice.
cathepsin g deficiency
Neutrophil influx into the lungs of beige mice is followed by elastolytic damage and emphysema.
Central Nervous System Infections
Proteolytic activity in CSF.
Cerebrovascular Disorders
Characterization of polymorphic structure of cathepsin G gene: role in cardiovascular and cerebrovascular diseases.
Chediak-Higashi Syndrome
Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency.
Chediak-Higashi Syndrome
Neutrophil elastase and cathepsin G protein and messenger RNA expression in bone marrow from a patient with Chediak-Higashi syndrome.
Cholangitis, Sclerosing
Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis.
Cholangitis, Sclerosing
Antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis: defined specificities may be associated with distinct clinical features.
Cholera
Effect of cell shape on proteinase secretion by epithelial cells.
Chronic Periodontitis
Cathepsin G in gingival tissue and crevicular fluid in adult periodontitis.
Chronic Periodontitis
Identification and possible function of cathepsin G in gingival crevicular fluid from chronic adult periodontitis patients and from experimental gingivitis subjects.
Chronic Periodontitis
Intracellular localization of Treponema denticola chymotrypsin-like proteinase in chronic periodontitis.
Chronic Periodontitis
Relationship of collagenase and cathepsin G activity in gingival crevicular fluid.
Colitis
Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice: Role of cathepsin G and protease-activated receptor-4.
Colitis, Ulcerative
Anti-cathepsin G antibodies in the sera of patients with ulcerative colitis.
Colitis, Ulcerative
Antibodies to cathepsin G in Crohn's disease.
Colitis, Ulcerative
Antigen specificity of circulating anti-neutrophil cytoplasmic antibodies in inflammatory bowel disease.
Colitis, Ulcerative
Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis.
Colitis, Ulcerative
Antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis: defined specificities may be associated with distinct clinical features.
Colitis, Ulcerative
Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice: Role of cathepsin G and protease-activated receptor-4.
Colitis, Ulcerative
Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice: role of cathepsin G and protease-activated receptor-4.
Colitis, Ulcerative
Luminal cathepsin g and protease-activated receptor 4: a duet involved in alterations of the colonic epithelial barrier in ulcerative colitis.
Colitis, Ulcerative
Neutrophil cytoplasmic antibodies (p-ANCA) in ulcerative colitis.
Colitis, Ulcerative
Novel autoantigens of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) in ulcerative colitis: non-histone chromosomal proteins, HMG1 and HMG2.
Colitis, Ulcerative
p-ANCA target antigens in ulcerative colitis.
Crohn Disease
Antibodies to cathepsin G in Crohn's disease.
Crohn Disease
Antigen specificity of circulating anti-neutrophil cytoplasmic antibodies in inflammatory bowel disease.
Crohn Disease
Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis.
Crohn Disease
Neutrophil and eosinophil involvement of the small bowel in patients with celiac disease and Crohn's disease: studies on the secretion rate and immunohistochemical localization of granulocyte granule constituents.
Cutis Laxa
Elastin production and degradation in cutis laxa acquisita.
Cystic Fibrosis
Cleavage of lymphocyte surface antigens CD2, CD4, and CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis.
Cystic Fibrosis
Cystic fibrosis sputum induces a secretory response from airway gland serous cells that can be prevented by neutrophil protease inhibitors.
Cystic Fibrosis
Effect of DNase on the activity of neutrophil elastase, cathepsin G and proteinase 3 in the presence of DNA.
Cystic Fibrosis
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Cystic Fibrosis
Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis.
Dementia
Increased elastase and cathepsin G activity in activated lymphocytes from aged patients Role of denutrition and dementia.
Demyelinating Diseases
Increased calpain expression in experimental demyelinating optic neuritis: an immunocytochemical study.
Dental Plaque
Cathepsin G in gingival tissue and crevicular fluid in adult periodontitis.
Dental Plaque
Cellular source, activation and inhibition of dental plaque collagenase.
Dermatitis, Atopic
Modulation of cathepsin G expression in severe atopic dermatitis following medium-dose UVA1 phototherapy.
Dermatomyositis
The role and mechanism of cathepsin G in dermatomyositis.
Diabetes Mellitus, Type 1
Downregulation of cathepsin G reduces the activation of CD4+ T cells in murine autoimmune diabetes.
Diabetes Mellitus, Type 1
Regulation of cathepsin g reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients.
Encephalomyelitis, Autoimmune, Experimental
Changes in cathepsins B-1 and D, neutral proteinase and 2',3'-cyclic nucleotide-3'-phosphohydrolase activities in monkey brain with experimental allergic encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Treatment of an encephalitogenic peptide from guinea pig myelin basic protein with alpha-protease and thermolysin. Isolation of fragments and determination of cleavage sites.
Endometriosis
Determination of cathepsin G in endometrial tissue using a surface plasmon resonance imaging biosensor with tailored phosphonic inhibitor.
Endotoxemia
Alternative pathways for angiotensin II production as an important determinant of kidney damage in endotoxemia.
Epstein-Barr Virus Infections
A Tolerogenic Role of Cathepsin G in a Primate Model of Multiple Sclerosis: Abrogation by Epstein-Barr Virus Infection.
Favism
Oxidative inactivation of the calcium-stimulated neutral proteinase from human red blood cells by divicine and intracellular protection by reduced glutathione.
Gingivitis
Identification and possible function of cathepsin G in gingival crevicular fluid from chronic adult periodontitis patients and from experimental gingivitis subjects.
Gingivitis
Immunohistochemical analysis of the gingiva with periodontitis of type I plasminogen deficiency compared to gingiva with gingivitis and periodontitis and healthy gingiva.
Gingivitis
Infection and apoptosis associated with inflammation in periodontitis: An immunohistologic study.
Gingivitis
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease.
Glioblastoma
Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells.
Glioma
Hydrogen Peroxide-Induced Oxidative Stress Activates Proteasomal Trypsin-Like Activity in Human U373 Glioma Cells.
Glomerulonephritis
Renal expression of matrix metalloproteinases in human ANCA-associated glomerulonephritis.
Glomerulonephritis
Studies on the glomerular filtration barrier and on the urinary excretion of basement membrane glycoproteins during the accelerated model of nephrotoxic serum nephritis.
Granuloma
Proteoglycan degrading activity in granulomatous inflammation: comparison between the C57b1/6 and C57bg/bg mouse.
Granuloma
Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice.
Heart Failure
Mast cell-derived cathepsin g: a possible role in the adverse remodeling of the failing human heart.
Hemangioendothelioma
Bone hemangioendothelioma: an immunohistochemical study related to histological malignancy and proliferative activity (NORs).
Hematologic Neoplasms
p53 abnormalities in B-cell prolymphocytic leukemia.
Hepatitis C, Chronic
Prevalence of ANCA in mixed cryoglobulinemia and chronic hepatitis C virus infection.
HIV Infections
Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection.
HIV Infections
N-terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4-68 variant.
HIV Infections
Thrombin activates envelope glycoproteins of HIV type 1 and enhances fusion.
Hyperalgesia
Up-regulation of Cathepsin G in the Development of Chronic Postsurgical Pain: An Experimental and Clinical Genetic Study.
Hyperhomocysteinemia
Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in Rats.
Hypersensitivity
Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice.
Hypertension
Effect of acetaldehyde upon cathepsin G and chymase. NRAS implications.
Hypertension
Mast cell derived carboxypeptidase A3 is decreased among patients with advanced coronary artery disease.
Infections
Airway proteins involved in bacterial clearance susceptible to cathepsin G proteolysis.
Infections
Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice.
Infections
Cathepsin G in Experimental Tuberculosis: Relevance for Antibacterial Protection and Potential for Immunotherapy.
Infections
Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection.
Infections
Effect of E. faecalis on the release of serine proteases elastase and cathepsin G, and collagenase-2 (MMP-8) by human polymorphonuclear leukocytes (PMNs).
Infections
Elastase and cathepsin G activities are present in immature bone marrow neutrophils and absent in late marrow and circulating neutrophils of beige (Chediak-Higashi) mice.
Infections
Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin.
Infections
Inactivation of human bronchial mucosal proteinase inhibitor by Pseudomonas aeruginosa elastase.
Infections
Inhibition of U-937 membrane-associated cathepsin G by GP120 (IIIB) and V3 loop-derived peptides from several strains of HIV-1.
Infections
Inhibitors of elastase and cathepsin G in Chédiak-Higashi (beige) neutrophils.
Infections
Lymphocryptovirus Infection of Nonhuman Primate B Cells Converts Destructive into Productive Processing of the Pathogenic CD8 T Cell Epitope in Myelin Oligodendrocyte Glycoprotein.
Infections
Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis.
Infections
Mediator responses of alveolar macrophages and kinetics of mononuclear phagocyte subset recruitment during acute primary and secondary mycobacterial infections in the lungs of mice.
Infections
Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1.
Infections
Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain.
Infections
Nonchromogenic hydrolysis of elastase and cathepsin G p-nitroanilide substrates by Pseudomonas aeruginosa elastase.
Infections
Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases.
Infections
Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke.
Infections
The down-regulation of cathepsin G in THP-1 monocytes after infection with Mycobacterium tuberculosis is associated with increased intracellular survival of bacilli.
Infections
The effects of Fasciola hepatica infection on the total antioxidant status (TAS) and the activity of proteases and their inhibitors in rat serum.
Infections
The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms.
Infections
[Flow-cytofluorometric study of bactericidal granules in blood phagocytes of animals with various species sensitivity to experimental plague infection].
Inflammatory Bowel Diseases
Antineutrophil cytoplasmic antibodies (ANCAs) in patients with inflammatory bowel disease show no correlation with proteinase 3, lactoferrin, myeloperoxidase, elastase, cathepsin G and lysozyme: a Singapore study.
Inflammatory Bowel Diseases
Antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis: defined specificities may be associated with distinct clinical features.
Influenza, Human
Critical Role of SerpinB1 in Regulating Inflammatory Responses in Pulmonary Influenza Infection.
Ischemic Stroke
Cathepsin g-dependent modulation of platelet thrombus formation in vivo by blood neutrophils.
Joint Diseases
Influence of some natural and semisynthetic agents on elastase and cathepsin G from polymorphonuclear granulocytes.
Joint Diseases
The degradation of articular collagen by neutrophil proteinases.
Keloid
Expression of Cathepsins B, D, and G by the Embryonic Stem Cell-Like Population within Human Keloid Tissues and Keloid-Derived Primary Cell Lines.
Keratoconus
Cathepsin G, acid phosphatase, and alpha 1-proteinase inhibitor messenger RNA levels in keratoconus corneas.
Keratoconus
Is the corneal degradation in keratoconus caused by matrix-metalloproteinases?
Leg Ulcer
Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers.
Leukemia
Adaptive immunity cooperates with liposomal all-trans-retinoic acid (ATRA) to facilitate long-term molecular remissions in mice with acute promyelocytic leukemia.
Leukemia
All-trans retinoic acid rapidly decreases cathepsin G synthesis and mRNA expression in acute promyelocytic leukemia.
Leukemia
Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences.
Leukemia
An enzyme immunoassay of human polymorphonuclear leukocyte cathepsin G.
Leukemia
Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target.
Leukemia
Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin.
Leukemia
Corynebacterium parvum, but not BCG, induces elevations in plasma proteinase activity similar to those observed in tumor-bearing mice.
Leukemia
High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression.
Leukemia
Immunocytochemical identification of abnormal polymorphonuclear neutrophils in patients with leukemia.
Leukemia
Increased plasma proteinase activity of mice bearing the BCL1 leukemia.
Leukemia
Plasma levels of human granulocytic elastase alpha 1-proteinase inhibitor complex (E-alpha 1-PI) in leukemia.
Leukemia
PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors.
Leukemia
Role of promyelocytic leukemia (PML) protein in tumor suppression.
Leukemia
The proximal promoter of the human cathepsin G gene conferring myeloid-specific expression includes C/EBP, c-myb and PU.1 binding sites.
Leukemia
Tumor cell metastasis and surface neutral proteinase: effects of antimetastatic and antitumor drugs.
Leukemia
[Lysosomal enzyme activity in white blood cells in leukemias]
Leukemia, Erythroblastic, Acute
Murine erythroleukemia cell differentiation: possible involvement of a calcium dependent neutral proteinase.
Leukemia, Lymphocytic, Chronic, B-Cell
p53 abnormalities in B-cell prolymphocytic leukemia.
Leukemia, Lymphoid
[Lysosomal enzyme activity in white blood cells in leukemias]
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Eryptotic phenotype in chronic myeloid leukemia: contribution of neutrophilic cathepsin g.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[Lysosomal enzyme activity in white blood cells in leukemias]
Leukemia, Myeloid
Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1.
Leukemia, Myeloid
Purification and characterization of a vimentin-specific protease in mouse myeloid leukemia cells. Regulation during differentiation and identity with cathepsin G.
Leukemia, Myeloid
Targeting cathepsin G in myeloid leukemia.
Leukemia, Myeloid, Acute
A novel HLA-A*0201 restricted peptide derived from cathepsin G is an effective immunotherapeutic target in acute myeloid leukemia.
Leukemia, Myeloid, Acute
AML1-ETO targets and suppresses cathepsin G, a serine protease, which is able to degrade AML1-ETO in t(8;21) acute myeloid leukemia.
Leukemia, Myeloid, Acute
Cathepsin G is broadly expressed in acute myeloid leukemia and is an effective immunotherapeutic target.
Leukemia, Myeloid, Acute
Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target.
Leukemia, Myeloid, Acute
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Leukemia, Promyelocytic, Acute
Adaptive immunity cooperates with liposomal all-trans-retinoic acid (ATRA) to facilitate long-term molecular remissions in mice with acute promyelocytic leukemia.
Leukemia, Promyelocytic, Acute
All-trans retinoic acid rapidly decreases cathepsin G synthesis and mRNA expression in acute promyelocytic leukemia.
Leukemia, Promyelocytic, Acute
High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression.
Leukemia, Promyelocytic, Acute
The proximal promoter of the human cathepsin G gene conferring myeloid-specific expression includes C/EBP, c-myb and PU.1 binding sites.
Lung Diseases
Airway proteins involved in bacterial clearance susceptible to cathepsin G proteolysis.
Lung Diseases
Mechanism-based inhibitors of serine proteinases based on the Gabriel-Colman rearrangement.
Lung Diseases
Protection of lung epithelial cells from protease-mediated injury by trappin-2 A62L, an engineered inhibitor of neutrophil serine proteases.
Lung Diseases
Separation of closely related peptide substrates of human proteinases by micellar electrokinetic chromatography with anionic and nonionic surfactants.
Lung Injury
Protective Effects of Chymostatin on Paraquat-Induced Acute Lung Injury in Mice.
Lung Injury
Suppression of superantigen-induced lung injury and vasculitis by preadministration of human urinary trypsin inhibitor.
Lung Neoplasms
Activity and tissue localization of cathepsin G in non small cell lung cancer.
Lung Neoplasms
Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin.
Lung Neoplasms
[Changes in serum protease and cytokine in patients with silicosis, tuberculosis, and lung cancer].
Lupus Erythematosus, Systemic
Anti-neutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Antibodies to human myeloperoxidase in glomerular immune deposits of systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Defensins- and cathepsin G-ANCA in systemic lupus erythematosus.
Lupus Nephritis
Antineutrophil cytoplasmic autoantibodies (ANCA) and their target antigens in Chinese patients with lupus nephritis.
Lymphatic Metastasis
[Comparative proteomics of the serum in patients with nasopharyngeal carcinoma: a study with two-dimensional electrophoresis and MALDI-TOF-MS]
Malaria
Anti-neutrophil cytoplasmic antibody (ANCA) in malaria is directed against cathepsin G.
Malnutrition
Effect of protein energy malnutrition on neutral proteinase in developing rat brain.
Mastocytoma
Purification and characterization of dog mastocytoma chymase: identification of an octapeptide conserved in chymotryptic leukocyte proteinases.
Melanoma
Corynebacterium parvum, but not BCG, induces elevations in plasma proteinase activity similar to those observed in tumor-bearing mice.
Melanoma
Evidence that the elevated levels of proteinase activity in the plasma of melanoma-bearing mice may be of host origin.
Melanoma
Expression of melanoma neutral proteinase and collagenase potential by endocytosis.
Melanoma, Experimental
Differences between beige and bg/+ mice in the disruption of plasma proteinase regulation in the tumor-bearing state or following Corynebacterium parvum treatment. Evidence for the involvement of polymorphonuclear leukocyte proteinases.
Multiple Sclerosis
A Tolerogenic Role of Cathepsin G in a Primate Model of Multiple Sclerosis: Abrogation by Epstein-Barr Virus Infection.
Multiple Sclerosis
Baisc protein hydrolysis in lymphocytes of Lewis rats with experimental allergic encephalomyelitis.
Multiple Sclerosis
Increased calpain expression in experimental demyelinating optic neuritis: an immunocytochemical study.
Multiple Sclerosis
Leucocyte proteinase activity and acute multiple sclerosis.
Multiple Sclerosis
Lysosomal hydrolases in cerebrospinal fluid of multiple sclerosis patients. A follow-up study.
Multiple Sclerosis
Proteolytic activity in CSF.
Muscular Dystrophies
Elevated activity of a neutral proteinase in human muscular dystrophy.
Mycoses
Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G.
Myocardial Ischemia
Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury.
Neoplasm Metastasis
Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand.
Neoplasm Metastasis
The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target.
Neoplasm Metastasis
Tumor cell metastasis and surface neutral proteinase: effects of antimetastatic and antitumor drugs.
Neoplasm Metastasis
[Comparative proteomics of the serum in patients with nasopharyngeal carcinoma: a study with two-dimensional electrophoresis and MALDI-TOF-MS]
Neoplasms
12-o-Tetradecanoyl-phorbol-13-acetate-differentiated U937 cells express a macrophage-like profile of neutral proteinases. High levels of secreted collagenase and collagenase inhibitor accompany low levels of intracellular elastase and cathepsin G.
Neoplasms
Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis.
Neoplasms
Activity and tissue localization of cathepsin G in non small cell lung cancer.
Neoplasms
Alpha1-antichymotrypsin and kallistatin hydrolysis by human cathepsin D.
Neoplasms
Bone hemangioendothelioma: an immunohistochemical study related to histological malignancy and proliferative activity (NORs).
Neoplasms
Cathepsin G and alpha 1-antichymotrypsin in the local host reaction to loosening of total hip prostheses.
Neoplasms
Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand.
Neoplasms
Cathepsin G recruits osteoclast precursors via proteolytic activation of protease-activated receptor-1.
Neoplasms
Cathepsin G, a neutrophil protease, induces compact cell-cell adhesion in MCF-7 human breast cancer cells.
Neoplasms
Cathepsin G-mediated activation of pro-matrix metalloproteinase 9 at the tumor-bone interface promotes transforming growth factor-beta signaling and bone destruction.
Neoplasms
Cathepsin G-mediated enhanced TGF-beta signaling promotes angiogenesis via upregulation of VEGF and MCP-1.
Neoplasms
Clathrin pit-mediated endocytosis of neutrophil elastase and cathepsin G by cancer cells.
Neoplasms
Comparison of the effects of auranofin and retinoic acid on plasminogen activator activity of peritoneal macrophages and Lewis lung carcinoma cells.
Neoplasms
Connective tissue degradation by invasive rat bladder carcinomas: action of nonspecific proteinases on collagenous matrices.
Neoplasms
Different Protein Expressions between Peripheral Ameloblastoma and Oral Basal Cell Carcinoma Occurred at the Same Mandibular Molar Area.
Neoplasms
Dissection of laminin by cathepsin G into its long-arm and short-arm structures and localization of regions involved in calcium dependent stabilization and self-association.
Neoplasms
Expression and Localization of Cathepsins B, D, and G in Two Cancer Stem Cell Subpopulations in Moderately Differentiated Oral Tongue Squamous Cell Carcinoma.
Neoplasms
Few smokers develop COPD. Why?
Neoplasms
Identification of proteases involved in the proteolysis of vascular endothelium cadherin during neutrophil transmigration.
Neoplasms
Induction of neutral proteinase and prostanoid production in bovine nasal chondrocytes by interleukin-1 and tumor necrosis factor alpha: modulation of these cellular responses by interleukin-6 and platelet-derived growth factor.
Neoplasms
Markedly elevated cell turnover is characteristic of small, deeply invasive carcinomas of the colorectum.
Neoplasms
Mechanisms Governing Anaphylaxis: Inflammatory Cells, Mediators, Endothelial Gap Junctions and Beyond.
Neoplasms
Neutrophil Cathepsin G and Tumor Cell RAGE Facilitate Neutrophil Anti-Tumor Cytotoxicity.
Neoplasms
Neutrophil extracellular trap formation in supragingival biofilms.
Neoplasms
Processing of human cathepsin G after transfection to the rat basophilic/mast cell tumor line RBL.
Neoplasms
Purification and further characterization of the Ca2+-activated proteinase specific for the intermediate filament proteins vimentin and desmin.
Neoplasms
Role of promyelocytic leukemia (PML) protein in tumor suppression.
Neoplasms
The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target.
Neoplasms
Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation.
Neoplasms
Tumor cell metastasis and surface neutral proteinase: effects of antimetastatic and antitumor drugs.
Neoplasms
Tumor necrosis factor-alpha enhances platelet activation via cathepsin G released from neutrophils.
Neoplasms
Tumor necrosis factor-alpha-induced proteolytic activation of pro-matrix metalloproteinase-9 by human skin is controlled by down-regulating tissue inhibitor of metalloproteinase-1 and mediated by tissue-associated chymotrypsin-like proteinase.
Neoplasms
Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin.
Neoplasms
Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression.
Nephritis
Different mediator systems in biphasic heterologous phase of anti-GBM nephritis in mice.
Neuroinflammatory Diseases
The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease.
Osteoarthritis
Quantitation of human leukocyte elastase, cathepsin G, alpha-2-macroglobulin and alpha-1-proteinase inhibitor in osteoarthrosis and rheumatoid arthritis synovial fluids.
Osteoarthritis
Quantitative analysis of elastase and cathepsin G mRNA levels in peripheral blood CD14(+) cells from patients with rheumatoid arthritis.
Osteoarthritis
Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium.
Osteolysis
Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand.
Osteolysis
Cathepsin G recruits osteoclast precursors via proteolytic activation of protease-activated receptor-1.
Osteomyelitis
The N125S polymorphism in the cathepsin G gene (rs45567233) is associated with susceptibility to osteomyelitis in a Spanish population.
Pancreatitis
Absence of the neutrophil serine protease cathepsin G decreases neutrophil granulocyte infiltration but does not change the severity of acute pancreatitis.
Pancreatitis
Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin.
Pancreatitis
Inhibition of neutrophil proteinases by recombinant serpin Lex032 reduces capillary no-reflow in ischemia/reperfusion-induced acute pancreatitis.
Pancreatitis
Release of dog polymorphonuclear leukocyte cathepsin G, normally and in endotoxin and pancreatitic shock. Isolation and partial characterization of dog polymorphonuclear leukocyte cathepsin G.
Periodontal Diseases
Cytopathic effects of Treponema denticola chymotrypsin-like proteinase on migrating and stratified epithelial cells.
Periodontal Diseases
Salivary levels of alpha 2-macroglobulin, alpha 1-antitrypsin, C-reactive protein, cathepsin G and elastase in humans with or without destructive periodontal disease.
Periodontal Diseases
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease.
Periodontal Pocket
Relationship of collagenase and cathepsin G activity in gingival crevicular fluid.
Periodontitis
Acute myocardial infarction elevates serine protease activity in saliva of patients with periodontitis.
Periodontitis
Cathepsin G in gingival tissue and crevicular fluid in adult periodontitis.
Periodontitis
Cellular source, activation and inhibition of dental plaque collagenase.
Periodontitis
Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis patients.
Periodontitis
Identification and possible function of cathepsin G in gingival crevicular fluid from chronic adult periodontitis patients and from experimental gingivitis subjects.
Periodontitis
Immunohistochemical analysis of the gingiva with periodontitis of type I plasminogen deficiency compared to gingiva with gingivitis and periodontitis and healthy gingiva.
Periodontitis
Infection and apoptosis associated with inflammation in periodontitis: An immunohistologic study.
Periodontitis
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease.
Peritonitis
Purification and N-terminal amino-acid sequence analysis of rat polymorphonuclear leukocyte cathepsin G.
Plague
[Flow-cytofluorometric study of bactericidal granules in blood phagocytes of animals with various species sensitivity to experimental plague infection].
Pneumonia
Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry.
Pneumonia
Cathepsin G degradation of phospholipid transfer protein (PLTP) augments pulmonary inflammation.
Pneumonia
Collagenases and the serine proteinases elastase and cathepsin G in steroid-induced Pneumocystis carinii pneumonia.
Pneumonia
Dual Inhibition of Cathepsin G and Chymase is Effective in Animal Models of Pulmonary Inflammation.
Pneumonia
Inflammatory response to particles in the rat lung: secretion of acid and neutral proteinases by bronchoalveolar leucocytes.
Pneumonia
Mutants of plasminogen activator inhibitor-1 designed to inhibit neutrophil elastase and cathepsin G are more effective in vivo than their endogenous inhibitors.
Pneumonia
Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases.
Pneumonia, Pneumocystis
Collagenases and the serine proteinases elastase and cathepsin G in steroid-induced Pneumocystis carinii pneumonia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target.
Prostatic Neoplasms
Anti-IL-20 Monoclonal Antibody Suppresses Prostate Cancer Growth and Bone Osteolysis in Murine Models.
Protein-Energy Malnutrition
Effect of protein energy malnutrition on neutral proteinase in developing rat brain.
Proteinuria
Studies on the glomerular filtration barrier and on the urinary excretion of basement membrane glycoproteins during the accelerated model of nephrotoxic serum nephritis.
Proteinuria
The human neutrophil serine proteinases, elastase and cathepsin G, can mediate glomerular injury in vivo.
Psoriasis
Cathepsin G cleaves and activates IL-36? and promotes the inflammation of psoriasis.
Psoriasis
Downregulation of interleukin 36? and its cleaver cathepsin G following treatment with narrow-band ultraviolet B phototherapy in psoriasis vulgaris.
Psoriasis
Inhibition of Neutrophil Elastase and Cathepsin G As a New Approach to the Treatment of Psoriasis: From Fundamental Biology to Development of New Target-Specific Drugs.
Psoriasis
Neutral proteinases and other neutrophil enzymes in psoriasis, and their relation to disease activity.
Psoriasis
The activity of polymorphonuclear leukocyte neutral proteinases and their inhibitors in patients with psoriasis treated with a continuous peritoneal dialysis.
Pulmonary Disease, Chronic Obstructive
A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
Pulmonary Disease, Chronic Obstructive
Cathepsin G degradation of phospholipid transfer protein (PLTP) augments pulmonary inflammation.
Pulmonary Disease, Chronic Obstructive
Dual Inhibition of Cathepsin G and Chymase is Effective in Animal Models of Pulmonary Inflammation.
Pulmonary Disease, Chronic Obstructive
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Pulmonary Disease, Chronic Obstructive
Lung tissue destruction by proteinase 3 and cathepsin G mediated elastin degradation is elevated in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Proteases and antiproteases.
Pulmonary Disease, Chronic Obstructive
Proteinase/proteinase inhibitor imbalance in sputum sol phases from patients with chronic obstructive pulmonary disease. Suggestions for a key role played by antileukoprotease.
Pulmonary Edema
Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema.
Pulmonary Emphysema
Leukoproteinases and pulmonary emphysema: cathepsin G and other chymotrypsin-like proteinases enhance the elastolytic activity of elastase on lung elastin.
Pulmonary Emphysema
Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.
Pulmonary Emphysema
Structure, function, and control of neutrophil proteinases.
Purpura
[Activities of proteinases in invertebrate animals--potential objects of fish nutrition. Effects of temperature, pH, and heavy metals]
Renal Insufficiency, Chronic
Elastase and cathepsin G from primed leukocytes cleave vascular endothelial cadherin in hemodialysis patients.
Reperfusion Injury
Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury.
Respiratory Distress Syndrome
Activation of human platelets by C5a-stimulated neutrophils: a role for cathepsin G.
Respiratory Distress Syndrome
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Sarcoma
[Neutral proteinase of transplantable sarcoma tissue from rats]
Sarcoma, Avian
Purification and properties of extracellular matrix-degrading metallo-proteinase overproduced by Rous sarcoma virus-transformed rat liver cell line, and its identification as transin.
Sarcoma, Yoshida
Cartilage-degrading neutral proteinase secreted by Yoshida sarcoma cells. Purification and properties.
Scleroderma, Diffuse
[Prevalence and clinical significance of cathepsin G antibodies in systemic sclerosis]
Scleroderma, Limited
[Prevalence and clinical significance of cathepsin G antibodies in systemic sclerosis]
Scleroderma, Systemic
Autoantibodies to bactericidal/permeability-increasing protein and cathepsin G in systemic sclerosis.
Scleroderma, Systemic
Bactericidal/permeability-increasing protein and cathepsin G are the major antigenic targets of antineutrophil cytoplasmic autoantibodies in systemic sclerosis.
Scleroderma, Systemic
[Prevalence and clinical significance of cathepsin G antibodies in systemic sclerosis]
Sepsis
Effect of various genetic polymorphisms on the incidence and outcome of severe sepsis.
Sepsis
Human leukocyte elastase and cathepsin G inactivate factor VII by limited proteolysis.
Sepsis
Identification of a 14kDa endocan fragment generated by cathepsin G, a novel circulating biomarker in patients with sepsis.
Sepsis
Protease inhibitors protect macrophages from lipopolysaccharide-induced cytotoxicity: possible role for NF-kappaB.
Sepsis
Proteinase inhibitors in severe inflammatory processes (septic shock and experimental endotoxaemia): biochemical, pathophysiological and therapeutic aspects.
Shock, Septic
Therapeutic effects of the combination of two proteinase inhibitors in endotoxin shock of the pig.
Silicosis
[Changes in serum protease and cytokine in patients with silicosis, tuberculosis, and lung cancer].
Silicosis
[Comparative analysis of serum proteomic profiles between patients with silicosis and chronic bronchitis].
Sjogren's Syndrome
Normal but not altered mucins activate neutrophils.
Skin Diseases
Ultrastructural changes of the skin induced by human leukocyte elastase and cathepsin G.
Small Cell Lung Carcinoma
Activity and tissue localization of cathepsin G in non small cell lung cancer.
Squamous Cell Carcinoma of Head and Neck
Bioinformatics Analyses Indicate That Cathepsin G (CTSG) is a Potential Immune-Related Biomarker in Oral Squamous Cell Carcinoma (OSCC).
ST Elevation Myocardial Infarction
Low-grade endotoxaemia enhances artery thrombus growth via Toll-like receptor 4: implication for myocardial infarction.
Subarachnoid Hemorrhage
Alpha1-antichymotrypsin gene (SERPINA3) A/T polymorphism as a risk factor for aneurysmal subarachnoid hemorrhage.
Thrombosis
Activities of proteases in parietal thrombus of aortic aneurysm.
Thrombosis
Cathepsin g-dependent modulation of platelet thrombus formation in vivo by blood neutrophils.
Thrombosis
Characterization of polymorphic structure of cathepsin G gene: role in cardiovascular and cerebrovascular diseases.
Thrombosis
Effects of cathepsin G pretreatment of platelets on their subsequent responses to aggregating agents.
Thrombosis
Hemorphin 7 reflects hemoglobin proteolysis in abdominal aortic aneurysm.
Thrombosis
Human neutrophil cathepsin G is a potent platelet activator.
Thrombosis
Neutrophil cathepsin G modulates platelet P-selectin expression and inhibits P-selectin-mediated platelet-neutrophil adhesion.
Thrombosis
Neutrophil cathepsin G modulates the platelet surface expression of the glycoprotein (GP) Ib-IX complex by proteolysis of the von Willebrand factor binding site on GPIb alpha and by a cytoskeletal-mediated redistribution of the remainder of the complex.
Thrombosis
Neutrophil derived cathepsin G induces potentially thrombogenic changes in human endothelial cells: a scanning electron microscopy study in static and dynamic conditions.
Thrombosis
Protease-activated receptor 4: a critical participator in inflammatory response.
Thrombosis
Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases.
Tuberculosis
Cathepsin G in Experimental Tuberculosis: Relevance for Antibacterial Protection and Potential for Immunotherapy.
Tuberculosis
Inhibition of the Plasma-Membrane-Associated Serine Protease Cathepsin G by Mycobacterium tuberculosis Rv3364c Suppresses Caspase-1 and Pyroptosis in Macrophages.
Tuberculosis
The down-regulation of cathepsin G in THP-1 monocytes after infection with Mycobacterium tuberculosis is associated with increased intracellular survival of bacilli.
Tuberculosis
[Changes in serum protease and cytokine in patients with silicosis, tuberculosis, and lung cancer].
Urticaria
Heterozygous alpha 1-antichymotrypsin deficiency may be associated with cold urticaria.
Urticaria Pigmentosa
Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions.
Uterine Cervical Neoplasms
Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin.
Vascular System Injuries
Cathepsin G activates protease-activated receptor-4 in human platelets.
Vascular System Injuries
Neutrophil derived cathepsin G induces potentially thrombogenic changes in human endothelial cells: a scanning electron microscopy study in static and dynamic conditions.
Vasculitis
Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis.
Vasculitis
Cutaneous vasculitis in breast cancer treated with chemotherapy.
Vasculitis
Molecular characteristics of anti-self antibody fragments against neutrophil cytoplasmic antigens from human V gene phage display libraries.
Venous Thrombosis
Inhibition by heparin of platelet activation induced by neutrophil-derived cathepsin G.
Vitamin A Deficiency
Neutrophil cathepsin G is specifically decreased under vitamin A deficiency.
Whooping Cough
Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection.
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Tschesche, H.; Wenzel, H.R.; Engelbrecht, S.; Schnabel, E.
Cathepsin G
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
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Cathepsin G
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1981
Homo sapiens
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Heck, L.W.; Rostand, K.S.; Hunter, F.A.; Bhown, A.
Isolation, characterization, and amino-terminal amino acid sequence analysis of human neutrophil cathepsin G from normal donors
Anal. Biochem.
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1986
Homo sapiens
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Virca, G.D.; Metz, G.; Schnebli, H.P.
Similarities between human and rat leukocyte elastase and cathepsin G
Eur. J. Biochem.
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1984
Homo sapiens, Rattus norvegicus
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Starkey, P.M.; Barrett, A.J.
Human cathepsin G
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1976
Homo sapiens
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Starkey, P.M.; Barret, A.J.
Neutral proteinases of human spleen. Purification and criteria for homogeneity of elastase and cathepsin G
Biochem. J.
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1976
Homo sapiens
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Braun, N.J.; Bodmer, J.L.; Virca, G.D.; Metz-Virca, G.; Maschler, R.; Bieth, J.G.; Schnebli, H.P.
Kinetic studies on the interaction of eglin c with human leukocyte elastase and cathepsin G
Biol. Chem. Hoppe-Seyler
368
299-308
1987
Homo sapiens
brenda
Stein, R.L.; Strimpler, A.M.
Slow-binding inhibition of chymotrypsin and cathepsin G by the peptide aldehyde chymostatin
Biochemistry
26
2611-2615
1987
Homo sapiens
brenda
Saklatvala, J.; Barrett, A.J.
Identification of proteinases in rheumatoid synovium. Detection of leukocyte elastase cathepsin G and another serine proteinase
Biochim. Biophys. Acta
615
167-177
1980
Homo sapiens
brenda
Lively, M.O.; Powers, J.C.
Specificity and reactivity of human granulocyte elastase and cathepsin G, porcine pancreatic elastase, bovine chymotrypsin and trypsin toward inhibition with sulfonyl fluorides
Biochim. Biophys. Acta
525
171-179
1978
Homo sapiens
brenda
Powers, J.C.; Gupton, B.F.; Harley, A.D.; Nishino, N.; Whitley, R.J.
Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G. Inhibition with peptide chloromethyl ketones
Biochim. Biophys. Acta
485
156-166
1977
Homo sapiens
brenda
Duranton, J.; Adam, C.; Bieth, J.G.
Kinetic mechanism of the inhibition of cathepsin G by alpha 1-antichymotrypsin and alpha 1-proteinase inhibitor
Biochemistry
37
11239-11245
1998
Homo sapiens
brenda
Bania, J.; Stachowiak, D.; Polanowski, A.
Primary structure and properties of the cathepsin G/chymotrypsin inhibitor from the larval hemolymph of Apis mellifera
Eur. J. Biochem.
262
680-687
1999
Homo sapiens
brenda
Ermolieff, J.; Boudier, C.; Laine, A.; Meyer, B.; Bieth, J.G.
Heparin protects cathepsin G against inhibition by protein proteinase inhibitor
J. Biol. Chem.
269
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1994
Homo sapiens
brenda
Pidard, D.; Renesto, P.; Berndt, M.C.; Rabhi, S.; Clemetsons, K.J.; Chignard, M.
Neutrophil proteinase cathepsin G is proteolytically active on the human platelet glycoprotein Ib-IX receptor: characterization of the cleavage sites within the glycoprotein Ib alpha subunit
Biochem. J.
303
489-498
1994
Homo sapiens
brenda
Hogg, P.J.; Owensby, D.A.; Chesterman, C.N.
Thrombospondin 1 is a tight-binding competitive inhibitor of neutrophil cathepsin G. Determination of the kinetic mechanism of inhibition and localization of cathepsin G binding to the thrombospondin 1 type 3 repeats
J. Biol. Chem.
268
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1993
Homo sapiens
brenda
Groutas, W.C.; Brubaker, M.J.; Verkataraman, R.; Epp, J.B.; Stang, M.A.; McClenahan, J.J.
Inhibitors of human neutrophil cathepsin G: structural and biochemical studies
Arch. Biochem. Biophys.
294
114-146
1992
Homo sapiens
-
brenda
Turkington, P.T.
Cathepsin G, a regulator of human vitamin K, dependent clotting factors and inhibitors
Thromb. Res.
67
147-155
1992
Homo sapiens
brenda
Hof, P.; Mayr, I.; Huber, R.; Korzus, E.; Potempa, J.; Travis, J.; Powers, J.C.; Bode, W.
The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities
EMBO J.
15
5481-5491
1996
Homo sapiens
brenda
Maison, C.M.; Villiers, C.L.; Colomb, M.G.
Proteolysis of C3 on U937 cell plasma membranes. Purification of cathepsin G
J. Immunol.
147
921-926
1991
Homo sapiens
brenda
Gutschow, M.; Kuerschner, L.; Pietsch, M.; Ambrozak, A.; Neumann, U.; Gunther, R.; Hofmann, H.J.
Inhibition of cathepsin G by 2-amino-3,1-benzoxazin-4-ones: kinetic investigations and docking studies
Arch. Biochem. Biophys.
402
180-191
2002
Homo sapiens
brenda
Tani, K.; Murphy, W.J.; Chertov, O.; Oppenheim, J.J.; Wang, J.M.
The neutrophil granule protein cathepsin G activates murine T lymphocytes and upregulates antigen-specific IG production in mice
Biochem. Biophys. Res. Commun.
282
971-976
2001
Homo sapiens
brenda
Vagnoni, L.M.; Gronostaj, M.; Kerrigan, J.E.
6-Acylamino-2-[(ethylsulfonyl)oxy]-1H-isoindole-1,3-diones mechanism-based inhibitors of human leukocyte elastase and cathepsin G: effect of chirality in the 6-acylamino substituent on inhibitory potency and selectivity
Bioorg. Med. Chem.
9
637-645
2001
Homo sapiens
brenda
Robledo, O.; Papaioannou, A.; Ochietti, B.; Beauchemin, C.; Legault, D.; Cantin, A.; King, P.D.; Daniel, C.; Alakhov, V.Y.; Potworowski, E.F.; St-Pierre, Y.
ICAM-1 isoforms: specific activity and sensitivity to cleavage by leukocyte elastase and cathepsin G
Eur. J. Immunol.
33
1351-1360
2003
Homo sapiens
brenda
Ledoux, D.; Merciris, D.; Barritault, D.; Caruelle, J.P.
Heparin-like dextran derivatives as well as glycosaminoglycans inhibit the enzymatic activity of human cathepsin G
FEBS Lett.
537
23-29
2003
Homo sapiens
brenda
Selim, T.E.; Ghoneim, H.R.; Abdel Ghaffar, H.A.; Colman, R.W.; Dela Cadena, R.A.
High molecular mass kininogen inhibits cathepsin G-induced platelet activation by forming a complex with cathepsin G
Hematol. J.
2
371-377
2001
Homo sapiens
brenda
Greco, M.N.; Hawkins, M.J.; Powell, E.T.; Almond, H.R., Jr.; Corcoran, T.W.; de Garavilla, L.; Kauffman, J.A.; Recacha, R.; Chattopadhyay, D.; Andrade-Gordon, P.; Maryanoff, B.E.
Nonpeptide inhibitors of cathepsin G: optimization of a novel beta-ketophosphonic acid lead by structure-based drug design
J. Am. Chem. Soc.
124
3810-3811
2002
Homo sapiens
brenda
Sambrano, G.R.; Huang, W.; Faruqi, T.; Mahrus, S.; Craik, C.; Coughlin, S.R.
Cathepsin G activates protease-activated receptor-4 in human platelets
J. Biol. Chem.
275
6819-6823
2000
Homo sapiens
brenda
Goel, M.S.; Diamond, S.L.
Neutrophil cathepsin G promotes prothrombinase and fibrin formation under flow conditions by activating fibrinogen-adherent platelets
J. Biol. Chem.
278
9458-9463
2003
Homo sapiens
brenda
Moriuchi, H.; Moriuchi, M.; Fauci, A.S.
Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection
J. Virol.
74
6849-6855
2000
Homo sapiens
brenda
Biggs, J.R.; Yang, J.; Gullberg, U.; Muchardt, C.; Yaniv, M.; Kraft, A.S.
The human brm protein is cleaved during apoptosis: the role of cathepsin G
Proc. Natl. Acad. Sci. USA
98
3814-3819
2001
Homo sapiens
brenda
Bonnefoy, A.; Legrand, C.
Proteolysis of subendothelial adhesive glycoproteins (fibronectin, thrombospondin, and von Willebrand factor) by plasmin, leukocyte cathepsin G, and elastase
Thromb. Res.
98
323-332
2000
Homo sapiens
brenda
Sissi, C.; Lucatello, L.; Naggi, A.; Torri, G.; Palumbo, M.
Interactions of low-molecular-weight semi-synthetic sulfated heparins with human leukocyte elastase and human Cathepsin G
Biochem. Pharmacol.
71
287-293
2006
Homo sapiens
brenda
Mezyk-Kope?, R.; Bzowska, M.; Bzowska, M.; Mickowska, B.; Mak, P.; Potempa, J.; Bereta, J.
Effects of elastase and cathepsin G on the levels of membrane and soluble TNFalpha
Biol. Chem.
386
801-811
2005
Homo sapiens
brenda
Yui, S.; Tomita, K.; Kudo, T.; Ando, S.; Yamazaki, M.
Induction of multicellular 3-D spheroids of MCF-7 breast carcinoma cells by neutrophil-derived cathepsin G and elastase
Cancer Sci.
96
560-570
2005
Homo sapiens
brenda
Helske, S.; Syvaeranta, S.; Kupari, M.; Lappalainen, J.; Laine, M.; Lommi, J.; Turto, H.; Maeyraenpaeae, M.; Werkkala, K.; Kovanen, P.T.; Lindstedt, K.A.
Possible role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves
Eur. Heart J.
27
1495-1504
2006
Homo sapiens
brenda
Tralau, T.; Meyer-Hoffert, U.; Schroeder, J.M.; Wiedow, O.
Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis
Exp. Dermatol.
13
316-325
2004
Homo sapiens
brenda
Raptis, S.Z.; Shapiro, S.D.; Simmons, P.M.; Cheng, A.M.; Pham, C.T.
Serine protease cathepsin G regulates adhesion-dependent neutrophil effector functions by modulating integrin clustering
Immunity
22
679-691
2005
Homo sapiens
brenda
Rivera-Marrero, C.A.; Stewart, J.; Shafer, W.M.; Roman, J.
The down-regulation of cathepsin G in THP-1 monocytes after infection with Mycobacterium tuberculosis is associated with increased intracellular survival of bacilli
Infect. Immun.
72
5712-5721
2004
Homo sapiens
brenda
Stefansson, S.; Yepes, M.; Gorlatova, N.; Day, D.E.; Moore, E.G.; Zabaleta, A.; McMahon, G.A.; Lawrence, D.A.
Mutants of plasminogen activator inhibitor-1 designed to inhibit neutrophil elastase and cathepsin G are more effective in vivo than their endogenous inhibitors
J. Biol. Chem.
279
29981-29987
2004
Homo sapiens
brenda
de Garavilla, L.; Greco, M.N.; Sukumar, N.; Chen, Z.W.; Pineda, A.O.; Mathews, F.S.; Di Cera, E.; Giardino, E.C.; Wells, G.I.; Haertlein, B.J.; Kauffman, J.A.; Corcoran, T.W.; Derian, C.K.; Eckardt, A.J.; Damiano, B.P.; Andrade-Gordon, P.; Maryanoff, B.E.
A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo
J. Biol. Chem.
280
18001-18007
2005
Homo sapiens (P08311), Homo sapiens
brenda
Shao, B.; Belaaouaj, A.; Verlinde, C.L.; Fu, X.; Heinecke, J.W.
Methionine sulfoxide and proteolytic cleavage contribute to the inactivation of cathepsin G by hypochlorous acid: an oxidative mechanism for regulation of serine proteinases by myeloperoxidase
J. Biol. Chem.
280
29311-29321
2005
Homo sapiens
brenda
Legedz, L7.; Randon, J.; Sessa, C.; Baguet, J.P.; Feugier, P.; Cerutti, C.; McGregor, J.; Bricca, G.
Cathepsin G is associated with atheroma formation in human carotid artery
J. Hypertens.
22
157-166
2004
Homo sapiens
brenda
Burster, T.; Beck, A.; Tolosa, E.; Marin-Esteban, V.; Roetzschke, O.; Falk, K.; Lautwein, A.; Reich, M.; Brandenburg, J.; Schwarz, G.; Wiendl, H.; Melms, A.; Lehmann, R.; Stevanovic, S.; Kalbacher, H.; Driessen, C.
Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes
J. Immunol.
172
5495-5503
2004
Homo sapiens
brenda
Sun, R.; Iribarren, P.; Zhang, N.; Zhou, Y.; Gong, W.; Cho, E.H.; Lockett, S.; Chertov, O.; Bednar, F.; Rogers, T.J.; Oppenheim, J.J.; Wang, J.M.
Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor
J. Immunol.
173
428-436
2004
Homo sapiens
brenda
Lesner, A.; Wysocka, M.; Guzow, K.; Wiczk, W.; Legowska, A.; Rolka, K.
Development of sensitive cathepsin G fluorogenic substrate using combinatorial chemistry methods
Anal. Biochem.
375
306-312
2008
Homo sapiens
brenda
Korkmaz, B.; Moreau, T.; Gauthier, F.
Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions
Biochimie
90
227-242
2008
Homo sapiens (P08311), Homo sapiens
brenda
Burster, T.; Beck, A.; Poeschel, S.; Oren, A.; Baechle, D.; Reich, M.; Roetzschke, O.; Falk, K.; Boehm, B.O.; Youssef, S.; Kalbacher, H.; Overkleeft, H.; Tolosa, E.; Driessen, C.
Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro
Immunology
121
82-93
2007
Homo sapiens, Mus musculus
brenda
Campbell, E.J.; Owen, C.A.
The sulfate groups of chondroitin sulfate- and heparan sulfate-containing proteoglycans in neutrophil plasma membranes are novel binding sites for human leukocyte elastase and cathepsin G
J. Biol. Chem.
282
14645-14654
2007
Homo sapiens
brenda
Rykl, J.; Thiemann, J.; Kurzawski, S.; Pohl, T.; Gobom, J.; Zidek, W.; Schlueter, H.
Renal cathepsin G and angiotensin II generation
J. Hypertens.
24
1797-1807
2006
Homo sapiens (P08311), Sus scrofa (Q95284), Sus scrofa
brenda
Lim, J.K.; Lu, W.; Hartley, O.; DeVico, A.L.
N-terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4-68 variant
J. Leukoc. Biol.
80
1395-1404
2006
Homo sapiens
brenda
Wysocka, M.; Legowska, A.; Bulak, E.; Jaskiewicz, A.; Miecznikowska, H.; Lesner, A.; Rolka, K.
New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P1 selected by combinatorial chemistry methods
Mol. Divers.
11
93-99
2007
Homo sapiens
brenda
Miyata, J.; Tani, K.; Sato, K.; Otsuka, S.; Urata, T.; Lkhagvaa, B.; Furukawa, C.; Sano, N.; Sone, S.
Cathepsin G: the significance in rheumatoid arthritis as a monocyte chemoattractant
Rheumatol. Int.
27
375-382
2007
Homo sapiens
brenda
Gale, A.J.; Rozenshteyn, D.
Cathepsin G, a leukocyte protease, activates coagulation factor VIII
Thromb. Haemost.
99
44-51
2008
Homo sapiens
brenda
Peterszegi, G.; Texier, S.; Robert, A.M.; Moulias, R.; Robert, L.
Increased elastase and cathepsin G activity in activated lymphocytes from aged patients Role of denutrition and dementia
Arch. Gerontol. Geriatr.
25
285-298
2008
Homo sapiens
brenda
Sienczyk, M.; Lesner, A.; Wysocka, M.; Legowska, A.; Pietrusewicz, E.; Rolka, K.; Oleksyszyn, J.
New potent cathepsin G phosphonate inhibitors
Bioorg. Med. Chem.
16
8863-8867
2008
Homo sapiens
brenda
Wilson, T.J.; Nannuru, K.C.; Singh, R.K.
Cathepsin G recruits osteoclast precursors via proteolytic activation of protease-activated receptor-1
Cancer Res.
69
3188-3195
2009
Homo sapiens, Mus musculus
brenda
Stoeckle, C.; Sommandas, V.; Adamopoulou, E.; Belisle, K.; Schiekofer, S.; Melms, A.; Weber, E.; Driessen, C.; Boehm, B.O.; Tolosa, E.; Burster, T.
Cathepsin G is differentially expressed in primary human antigen-presenting cells
Cell. Immunol.
255
41-45
2009
Homo sapiens
brenda
Mambole, A.; Baruch, D.; Nusbaum, P.; Bigot, S.; Suzuki, M.; Lesavre, P.; Fukuda, M.; Halbwachs-Mecarelli, L.
The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase
J. Biol. Chem.
283
23627-23635
2008
Homo sapiens (P08311)
brenda
Korkmaz, B.; Attucci, S.; Juliano, M.A.; Kalupov, T.; Jourdan, M.L.; Juliano, L.; Gauthier, F.
Measuring elastase, proteinase 3 and cathepsin G activities at the surface of human neutrophils with fluorescence resonance energy transfer substrates
Nat. Protoc.
3
991-1000
2008
Homo sapiens
brenda
Dabek, M.; Ferrier, L.; Roka, R.; Gecse, K.; Annahazi, A.; Moreau, J.; Escourrou, J.; Cartier, C.; Chaumaz, G.; Leveque, M.; Ait-Belgnaoui, A.; Wittmann, T.; Theodorou, V.; Bueno, L.
Luminal cathepsin g and protease-activated receptor 4: a duet involved in alterations of the colonic epithelial barrier in ulcerative colitis
Am. J. Pathol.
175
207-214
2009
Homo sapiens
brenda
Burster, T.; Macmillan, H.; Hou, T.; Schilling, J.; Truong, P.; Boehm, B.O.; Zou, F.; Lau, K.; Strohman, M.; Schaffert, S.; Busch, R.; Mellins, E.D.
Masking of a cathepsin G cleavage site in vivo contributes to the proteolytic resistance of major histocompatibility complex class II molecules
Immunology
130
436-46
2010
Homo sapiens
brenda
Tausch, L.; Henkel, A.; Siemoneit, U.; Poeckel, D.; Kather, N.; Franke, L.; Hofmann, B.; Schneider, G.; Angioni, C.; Geisslinger, G.; Skarke, C.; Holtmeier, W.; Beckhaus, T.; Karas, M.; Jauch, J.; Werz, O.
Identification of human cathepsin G as a functional target of boswellic acids from the anti-inflammatory remedy frankincense
J. Immunol.
183
3433-3442
2009
Homo sapiens (P08311), Homo sapiens
brenda
Kudo, T.; Kigoshi, H.; Hagiwara, T.; Takino, T.; Yamazaki, M.; Yui, S.
Cathepsin G, a neutrophil protease, induces compact cell-cell adhesion in MCF-7 human breast cancer cells
Mediators Inflamm.
2009
850940
2009
Homo sapiens
brenda
Reich, M.; Lesner, A.; Legowska, A.; Sienczyk, M.; Oleksyszyn, J.; Boehm, B.O.; Burster, T.
Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells
Mol. Immunol.
46
2994-2999
2009
Homo sapiens
brenda
Burster, T.; Macmillan, H.; Hou, T.; Boehm, B.O.; Mellins, E.D.
Cathepsin G: roles in antigen presentation and beyond
Mol. Immunol.
47
658-665
2010
Homo sapiens, Mus musculus
brenda
Korkmaz, B.; Jegot, G.; Lau, L.C.; Thorpe, M.; Pitois, E.; Juliano, L.; Walls, A.F.; Hellman, L.; Gauthier, F.
Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates
FEBS J.
278
2635-2646
2011
Homo sapiens (P08311), Homo sapiens
brenda
Raymond, W.W.; Trivedi, N.N.; Makarova, A.; Ray, M.; Craik, C.S.; Caughey, G.H.
How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution
J. Immunol.
185
5360-5368
2010
Homo sapiens, Mus musculus
brenda
Siao, S.C.; Li, K.J.; Hsieh, S.C.; Wu, C.H.; Lu, M.C.; Tsai, C.Y.; Yu, C.L.
Tamm-Horsfall glycoprotein enhances PMN phagocytosis by binding to cell surface-expressed lactoferrin and cathepsin G that activates MAP kinase pathway
Molecules
16
2119-2134
2011
Homo sapiens
brenda
Zou, F.; Schaefer, N.; Palesch, D.; Bruecken, R.; Beck, A.; Sienczyk, M.; Kalbacher, H.; Sun, Z.; Boehm, B.O.; Burster, T.
Regulation of cathepsin G reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients
PLoS ONE
6
e22815
2011
Homo sapiens
brenda
Perrin, J.; Lecompte, T.; Tournier, A.; Morlon, L.; Marchand-Arvier, M.; Vigneron, C.
In vitro effects of human neutrophil cathepsin G on thrombin generation: Both acceleration and decreased potential
Thromb. Haemost.
104
514-522
2010
Homo sapiens
brenda
Wang, J.; Sjoeberg, S.; Tang, T.T.; Ooerni, K.; Wu, W.; Liu, C.; Secco, B.; Tia, V.; Sukhova, G.K.; Fernandes, C.; Lesner, A.; Kovanen, P.T.; Libby, P.; Cheng, X.; Shi, G.P.
Cathepsin G activity lowers plasma LDL and reduces atherosclerosis
Biochim. Biophys. Acta
1842
2174-2183
2014
Homo sapiens (P08311), Homo sapiens, Mus musculus (P28293)
brenda
Cohen-Mazor, M.; Mazor, R.; Kristal, B.; Sela, S.
Elastase and cathepsin G from primed leukocytes cleave vascular endothelial cadherin in hemodialysis patients
BioMed Res. Int.
2014
459640
2014
Homo sapiens (P08311), Homo sapiens
brenda
Woloszynek, J.C.; Hu, Y.; Pham, C.T.
Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions
J. Biol. Chem.
287
34101-34109
2012
Homo sapiens (P08311)
brenda
Faraday, N.; Schunke, K.; Saleem, S.; Fu, J.; Wang, B.; Zhang, J.; Morrell, C.; Dore, S.
Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils
PLoS ONE
8
e71447
2013
Homo sapiens (P08311), Homo sapiens, Mus musculus (P28293), Mus musculus
brenda
Gudmann, N.S.; Manon-Jensen, T.; Sand, J.M.B.; Diefenbach, C.; Sun, S.; Danielsen, A.; Karsdal, M.A.; Leeming, D.J.
Lung tissue destruction by proteinase 3 and cathepsin G mediated elastin degradation is elevated in chronic obstructive pulmonary disease
Biochem. Biophys. Res. Commun.
503
1284-1290
2018
Homo sapiens
brenda
Groborz, K.; Kolt, S.; Kasperkiewicz, P.; Drag, M.
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation
Biochimie
166
103-111
2019
Homo sapiens
brenda
Gao, S.; Zhu, H.; Yang, H.; Zhang, H.; Li, Q.; Luo, H.
The role and mechanism of cathepsin G in dermatomyositis
Biomed. Pharmacother.
94
697-704
2017
Homo sapiens
brenda
Guo, J.; Tu, J.; Hu, Y.; Song, G.; Yin, Z.
Cathepsin G cleaves and activates IL-36gamma and promotes the inflammation of psoriasis
Drug Des. Devel. Ther.
13
581-588
2019
Homo sapiens
brenda
Penczek, A.; Sienczyk, M.; Wirtz, C.R.; Burster, T.
Cell surface cathepsin G activity differs between human natural killer cell subsets
Immunol. Lett.
179
80-84
2016
Homo sapiens
brenda
Fu, Z.; Thorpe, M.; Alemayehu, R.; Roy, A.; Kervinen, J.; de Garavilla, L.; Abrink, M.; Hellman, L.
Highly selective cleavage of cytokines and chemokines by the human mast cell chymase and neutrophil cathepsin G
J. Immunol.
198
1474-1483
2017
Homo sapiens
brenda
Eipper, S.; Steiner, R.; Lesner, A.; Sienczyk, M.; Palesch, D.; Halatsch, M.E.; Zaczynska, E.; Heim, C.; Hartmann, M.D.; Zimecki, M.; Wirtz, C.R.; Burster, T.
Lactoferrin is an allosteric enhancer of the proteolytic activity of cathepsin G
PLoS ONE
11
e0151509
2016
Homo sapiens
brenda
Thorpe, M.; Fu, Z.; Chahal, G.; Akula, S.; Kervinen, J.; de Garavilla, L.; Hellman, L.
Extended cleavage specificity of human neutrophil cathepsin G A low activity protease with dual chymase and tryptase-type specificities
PLoS ONE
13
e0195077
2018
Homo sapiens
brenda