Reference on EC 3.4.21.2 - chymotrypsin C
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kobayashi, Y.; Kobayashi, R.; Hirs, C.H.W.
Identification of zymogen E in a complex with bovine procarboxypeptidase A
J. Biol. Chem.
256
2466-2470
1981
Bos taurus
Sangild, P.T.; Weström, B.R.; Fowden, A.L.; Silver, M.
Developmental regulation of the porcine exocrine pancreas by glucocorticoids
J. Pediatr. Gastroenterol. Nutr.
19
204-212
1994
BRENDA: Sus scrofa
Textmining: Suidae
Thomson, A.; Denniss, I.S.
The identity of the elastase-associated acidic endopeptidase and chymotrypsin C from porcine pancreas
Biochim. Biophys. Acta
429
581-590
1976
Sus scrofa
Keil-Dlouha, V.; Puigserver, A.; Marie, A.; Keil, B.
On subunit II of bovine procarboxypeptidase A. Enzymatic specificity after tryptic activation
Biochim. Biophys. Acta
276
531-535
1972
Sus scrofa
Folk, J.E.; Schirmer, E.W.
Chymotrypsin C. I. Isolation of the zymogen and the active enzyme: preliminary structure and specificity studies
J. Biol. Chem.
240
181-192
1965
Sus scrofa
Folk, J.E.; Cole, P.W.
Chymotrypsin C. II. Enzymatic specificity toward several polypeptides
J. Biol. Chem.
240
193-197
1965
Sus scrofa
Peanasky, R.J.; Gratecos, D.; Baratti, J.; Rovery, M.
Mode of activation of N-terminal sequence of subunit II in bovine procarboxypeptidase A and of porcine chymotrypsinogen C
Biochim. Biophys. Acta
181
82-92
1969
Bos taurus, Sus scrofa
Gabert, V.M.; Jensen, M.S.; Weström, B.R.; Pierzynowski, S.G.
Electrophoretic separation of proteolytic enzymes in pancreatic juice collected with the pouch or catheter method
Int. J. Pancreatol.
22
39-43
1997
BRENDA: Sus scrofa
Textmining: Suidae
Kominami, E.; Hoffschulte, H.; Leuschel, L.; Maier, K.; Holzer, H.
The substrate specificity of proteinase B from baker's yeast
Biochim. Biophys. Acta
661
136-141
1981
Sus scrofa
Nemoda, Z.; Sahin-Toth, M.
Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen
J. Biol. Chem.
281
11879-11886
2006
Homo sapiens
Pao L.I.; Sumaria N.; Kelly J.M.; van Dommelen S.; Cretney E.; Wallace M.E.; Anthony D.A.; Uldrich A.P.; Godfrey D.I.; Papadimitriou J.M.; Mullbacher A.; Degli-Esposti M.A.; Smyth M.J.
Functional analysis of granzyme M and its role in immunity to infection
J. Immunol.
175
3235-3243
2005
Mus musculus
Josephrajkumar, A.; Chakrabarty, R.; Thomas, G.
Purification of elastase-like chymotrypsin from cardamom shoot and capsule bore
Indian J. Exp. Biol.
45
998-1002
2007
BRENDA: Conogethes punctiferalis
Textmining: Elettaria cardamomum
Rosendahl, J.; Witt, H.; Szmola, R.; Bhatia, E.; Ozsvari, B.; Landt, O.; Schulz, H.U.; Gress, T.M.; Pfuetzer, R.; Loehr, M.; Kovacs, P.; Blueher, M.; Stumvoll, M.; Choudhuri, G.; Hegyi, P.; te Morsche, R.H.; Drenth, J.P.; Truninger, K.; Macek, M.; Puhl, G.; Witt, U.; Schmidt, H.; Buening, C.; Ockenga, J.
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis
Nat. Genet.
40
78-82
2008
Homo sapiens
Szmola, R.; Sahin-Toth, M.
Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknechts enzyme Y
Proc. Natl. Acad. Sci. USA
104
11227-11232
2007
Homo sapiens (Q99895), Homo sapiens
Szmola, R.; Sahin-Toth, M.
Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells
Gut
59
365-372
2010
BRENDA: Homo sapiens
Textmining: Mus musculus, Rattus
Szabo, A.; Sahin-Toth, M.
Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen
FEBS J.
279
4283-4292
2012
Homo sapiens (Q99895), Homo sapiens
Beer, S.; Zhou, J.; Szabo, A.; Keiles, S.; Chandak, G.R.; Witt, H.; Sahin-Toth, M.
Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk
Gut
62
1616-1624
2013
Homo sapiens (Q99895), Homo sapiens
Batra, J.; Szabo, A.; Caulfield, T.R.; Soares, A.S.; Sahin-Toth, M.; Radisky, E.S.
Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation
J. Biol. Chem.
288
9848-9859
2013
Homo sapiens (Q99895), Homo sapiens
Szabo, A.; Ludwig, M.; Hegyi, E.; Szepeova, R.; Witt, H.; Sahin-Toth, M.
Mesotrypsin signature mutation in a chymotrypsin C (CTRC) variant associated with chronic pancreatitis
J. Biol. Chem.
290
17282-17292
2015
BRENDA: Homo sapiens (Q99895), Homo sapiens
Textmining: Bos taurus
Jancso, Z.; Sahin-Toth, M.
Tighter control by chymotrypsin C (CTRC) explains lack of association between human anionic trypsinogen and hereditary pancreatitis
J. Biol. Chem.
291
12897-12905
2016
Homo sapiens (Q99895), Homo sapiens
Nemeth, B.C.; Hegyi, P.; Takacs, T.
Evaluation of the pathogenic significance of the novel p.T58M chymotrypsin C variant in recurrent acute pancreatitis
Pancreas
48
E12-E14
2019
Homo sapiens (Q99895)
Kobayashi, K; Sanada, Y; Katunuma, N
Selective cleavage of peptide bonds by a serine protease from rat skeletal muscle.
J Biochem (Tokyo)
84
477-81
1978
Sus scrofa, Bos taurus
Ardelt, W; Tomczak, Z; Dudek-Wojciechowska, G
Specificity of elastases: degradation of the oxidized beta-chain of insulin by porcine pancreatic elastase II and dog leucocyte elastase.
Acta Biochim Pol
26
267-73
1979
Canis lupus familiaris, Sus scrofa, Homo sapiens
Blow, AM; Barrett, AJ
Action of human cathepsin G on the oxidized B chain of insulin.
Biochem J
161
17-9
1977
Sus scrofa
Tomomura, A; Fukushige, T; Noda, T; Noikura, T; Saheki, T
Serum calcium-decreasing factor (caldecrin) from porcine pancreas has proteolytic activity which has no clear connection with the calcium decrease.
FEBS Lett
301
277-81
1992
Sus scrofa
Iio-Akama, K; Sasamoto, H; Miyazawa, K; Miura, S; Tobita, T
Active forms of chymotrypsin C isolated from autolyzed porcine pancreas glands.
Biochim Biophys Acta
831
249-56
1985
Sus scrofa
Chen, JP; Reichlin, M; Tomasi, TB
Studies on the chymotrypsin C and papain fragments of human immunoglobulin M.
Biochemistry
8
2246-54
1969
Homo sapiens
Gratecos, D; Desnuelle, P
On a chymotrypsin C purified from autolyzed porcine pancreas.
Biochem Biophys Res Commun
42
857-64
1971
Sus scrofa
Gomis-Rüth, FX; Gómez, M; Bode, W; Huber, R; Avilés, FX
The three-dimensional structure of the native ternary complex of bovine pancreatic procarboxypeptidase A with proproteinase E and chymotrypsinogen C.
EMBO J
14
4387-94
1995
Bos taurus
Tomomura, A; Akiyama, M; Itoh, H; Yoshino, I; Tomomura, M; Nishii, Y; Noikura, T; Saheki, T
Molecular cloning and expression of human caldecrin.
FEBS Lett
386
26-8
1996
Homo sapiens, Rattus
Tomomura, A; Yamada, H; Itagaki, K; Fujimoto, K; Katoh, S
Rat brain expresses serum calcium-decreasing factor (caldecrin).
Neurosci Lett
317
17-20
2002
Rattus, Hippocampus
Masson, E; Chen, JM; Scotet, V; Le Maréchal, C; Férec, C
Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis.
Hum Genet
123
83-91
2008
Homo sapiens
Chang, MC; Chang, YT; Wei, SC; Liang, PC; Jan, IS; Su, YN; Kuo, CH; Wong, JM
Association of Novel Chymotrypsin C Gene Variations and Haplotypes in Patients with Chronic Pancreatitis in Chinese in Taiwan.
Pancreatology
9
287-292
2009
Homo sapiens
Szmola, R; Bence, M; Carpentieri, A; Szabó, A; Costello, CE; Samuelson, J; Sahin-Tóth, M
Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.
J Biol Chem
286
1819-27
2011
Homo sapiens
Tomomura, M; Fujii, T; Sakagami, H; Tomomura, A
Serum Calcium-decreasing Factor, Caldecrin, Ameliorates Muscular Dystrophy in dy/dy Mice.
In Vivo
25
157-63
0
Mus sp.
Szabó, A; Héja, D; Szakács, D; Zboray, K; Kékesi, KA; Radisky, ES; Sahin-Tóth, M; Pál, G
High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues.
J Biol Chem
286
22535-45
2011
Homo sapiens, Schistocerca gregaria
Wang, H; Yuan, D; Xu, R; Chi, CW
Purification, cDNA cloning, and recombinant expression of chymotrypsin C from porcine pancreas.
Acta Biochim Biophys Sin (Shanghai)
43
568-75
2011
Sus scrofa, Escherichia coli
Bence, M; Sahin-Tóth, M
Asparagine-linked glycosylation of human chymotrypsin C is required for folding and secretion but not for enzyme activity.
FEBS J
278
4338-50
2011
Homo sapiens, Rattus
Szabó, A; Sahin-Tóth, M
Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C.
J Biol Chem
287
20701-10
2012
Homo sapiens
Németh, BC; Wartmann, T; Halangk, W; Sahin-Tóth, M
Autoactivation of Mouse Trypsinogens Is Regulated by Chymotrypsin C via Cleavage of the Autolysis Loop.
J Biol Chem
288
24049-62
2013
Mus musculus, Homo sapiens
da Costa, MZ; Pires, JG; Nasser, PD; Ferreira, Cda S; Teixeira, AC; Paranaguá-Vezozzo, DC; Guarita, DR; Carrilho, FJ; Ono, SK
Frequency of Tabagism and N34S and P55S Mutations of Serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) and R254W Mutation of Chymotrypsin C (CTRC) in Patients With Chronic Pancreatitis and Controls.
Pancreas
45
1330-5
2016
Homo sapiens
da Costa, MZ; Pires, JG; Nasser, PD; Ferreira, CD; Teixeira, AC; Paranaguá-Vezozzo, DC; Guarita, DR; Carrilho, FJ; Ono, SK
Frequency of Tabagism and N34S and P55S Mutations of Serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) and R254W Mutation of Chymotrypsin C (CTRC) in Patients With Chronic Pancreatitis and Controls.
Pancreas
45
1330-1335
2016
Homo sapiens
Grabarczyk, AM; Oracz, G; Wertheim-Tysarowska, K; Kujko, AA; Wejnarska, K; Kolodziejczyk, E; Bal, J; Koziel, D; Kowalik, A; Gluszek, S; Rygiel, AM
Chymotrypsinogen C Genetic Variants, Including c.180TT, Are Strongly Associated With Chronic Pancreatitis in Pediatric Patients.
J Pediatr Gastroenterol Nutr
65
652-657
2017
Homo sapiens
Geisz, A; Jancsó, Z; Németh, BC; Hegyi, E; Sahin-Tóth, M
Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice.
JCI Insight
5
2019
Mus sp., Homo sapiens, animal
Szabó, A; Radisky, ES; Sahin-Tóth, M
Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation.
J Biol Chem
289
4753-61
2014
Homo sapiens
Kortt, AA
Specificity and stability of the chymotrypsin inhibitor from winged bean seed (Psophocarpus tetragonolobus (L) Dc).
Biochim Biophys Acta
657
212-21
1981
Psophocarpus tetragonolobus, Tetragonolobus
Raae, AJ; Flengsrud, R; Sletten, K
Chymotrypsin isoenzymes in Atlantic cod; differences in kinetics and substrate specificity.
Comp Biochem Physiol B Biochem Mol Biol
112
393-8
1995
Metazoa
Pascual, R; Vendrell, J; Avilés, FX; Bonicel, J; Wicker, C; Puigserver, A
Autolysis of proproteinase E in bovine procarboxypeptidase A ternary complex gives rise to subunit III.
FEBS Lett
277
37-41
1990
Bos taurus
Wang, W; Sun, XT; Weng, XL; Zhou, DZ; Sun, C; Xia, T; Hu, LH; Lai, XW; Ye, B; Liu, MY; Jiang, F; Gao, J; Bo, LM; Liu, Y; Liao, Z; Li, ZS
Comprehensive screening for PRSS1, SPINK1, CFTR, CTRC and CLDN2 gene mutations in Chinese paediatric patients with idiopathic chronic pancreatitis: a cohort study.
BMJ Open
3
e003150
2013
Homo sapiens
Schubert, S; Traub, F; Brakensiek, K; von Kopylow, K; Marohn, B; Maelzer, M; Gaedcke, J; Kreipe, H; Stuhrmann, M
CFTR, SPINK1, PRSS1, and CTRC Mutations Are Not Associated With Pancreatic Cancer in German Patients.
Pancreas
43
1078-82
2014
Homo sapiens
Szabó, A; Pilsak, C; Bence, M; Witt, H; Sahin-Tóth, M
Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.
J Biol Chem
291
17706-16
2016
Bos taurus
Saito, N; Suzuki, M; Sakurai, Y; Nakano, S; Naritaka, N; Minowa, K; Sai, JK; Shimizu, T
Genetic Analysis of Japanese Children With Acute Recurrent and Chronic Pancreatitis.
J Pediatr Gastroenterol Nutr
2016
Homo sapiens
Xiao, Y; Yuan, W; Yu, B; Guo, Y; Xu, X; Wang, X; Yu, Y; Yu, Y; Gong, B; Xu, C
Targeted Gene Next-Generation Sequencing in Chinese Children with Chronic Pancreatitis and Acute Recurrent Pancreatitis.
J Pediatr
191
158-163.e3
2017
Homo sapiens
Nabi, Z; Talukdar, R; Venkata, R; Aslam, M; Shava, U; Reddy, DN
Genetic Evaluation of Children with Idiopathic Recurrent Acute Pancreatitis.
Dig Dis Sci
2020
Homo sapiens
Huang, H; Swidnicka-Siergiejko, AK; Daniluk, J; Gaiser, S; Yao, Y; Peng, L; Zhang, Y; Liu, Y; Dong, M; Zhan, X; Wang, H; Bi, Y; Li, Z; Ji, B; Logsdon, CD
Transgenic Expression of PRSS1R122H Sensitizes Mice to Pancreatitis.
Gastroenterology
2019
Mus sp.
Gomis-Rüth, FX; Gómez, M; Ventura, S; Vendrell, J; Avilés, FX
Crystallization and preliminary X-ray analysis of the ternary complex of procarboxypeptidase A from bovine pancreas.
FEBS Lett
367
211-3
1995
Bos taurus
Yoshino-Yasuda, I; Kobayashi, K; Akiyama, M; Itoh, H; Tomomura, A; Saheki, T
Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene.
J Biochem (Tokyo)
123
546-54
1998
Homo sapiens, Rattus
Tomomura, A; Fukushige, T; Tomomura, M; Noikura, T; Nishii, Y; Saheki, T
Caldecrin proform requires trypsin activation for the acquisition of serum calcium-decreasing activity.
FEBS Lett
335
213-6
1993
Sus scrofa
Tomomura, A; Tomomura, M; Fukushige, T; Akiyama, M; Kubota, N; Kumaki, K; Nishii, Y; Noikura, T; Saheki, T
Molecular cloning and expression of serum calcium-decreasing factor (caldecrin).
J Biol Chem
270
30315-21
1995
Sus scrofa, Rattus
Tomomura, A; Yamada, H; Fujimoto, K; Inaba, A; Katoh, S
Determination of amino acid sequence responsible for suppression of bone resorption by serum calcium-decreasing factor (caldecrin).
FEBS Lett
508
454-8
2001
Rattus
Hasegawa, H; Kido, S; Tomomura, M; Fujimoto, K; Ohi, M; Kiyomura, M; Kanegae, H; Inaba, A; Sakagami, H; Tomomura, A
Serum calcium-decreasing factor, caldecrin, inhibits osteoclast differentiation by suppression of NFATc1 activity.
J Biol Chem
285
25448-57
2010
Mus musculus, Oryctolagus cuniculus
Wang, H; Sha, W; Liu, Z; Chi, CW
Effect of chymotrypsin C and related proteins on pancreatic cancer cell migration.
Acta Biochim Biophys Sin (Shanghai)
2011
plasmids
Zhou, J; Sahin-Tóth, M
Chymotrypsin C mutations in chronic pancreatitis.
J Gastroenterol Hepatol
26
1238-46
2011
Homo sapiens
Lacruz, RS; Smith, CE; Smith, SM; Hu, P; Bringas, P; Sahin-Tóth, M; Moradian-Oldak, J; Paine, ML
Chymotrypsin C (Caldecrin) Is Associated with Enamel Development.
J Dent Res
2011
Rattus
Paliwal, S; Bhaskar, S; Mani, KR; Reddy, DN; Rao, GV; Singh, SP; Thomas, V; Chandak, GR
Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants.
Gut
2012
Homo sapiens
Geisz, A; Hegyi, P; Sahin-Tóth, M
Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis-associated cationic trypsinogen mutants.
FEBS J
280
2888-99
2013
Homo sapiens
Tomomura, M; Tomomura, A
Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function.
World J Biol Chem
6
358-65
2015
Mus musculus, Mus sp.
Bandow, K; Hasegawa, H; Tomomura, M; Tomomura, A
Caldecrin inhibits lipopolysaccharide-induced pro-inflammatory cytokines and M1 macrophage polarization through the immunoreceptor triggering receptor expressed in myeloid cells-2.
Biochem Biophys Res Commun
523
1027-1033
2020
Mus musculus
Tomomura, A; Bandow, K; Tomomura, M
Purification and Biological Function of Caldecrin.
Medicines (Basel)
8
2021
Mus sp.
Kerfelec, B; Chapus, C; Puigserver, A
Existence of ternary complexes of procarboxypeptidase A in the pancreas of some ruminant species.
Eur J Biochem
151
515-9
1985
Bos taurus, Sus scrofa
Felderbauer, P; Karakas, E; Fendrich, V; Lebert, R; Bartsch, DK; Bulut, K
Multifactorial Genesis of Pancreatitis in Primary Hyperparathyroidism: Evidence for "Protective" (PRSS2) and "Destructive" (CTRC) Genetic Factors.
Exp Clin Endocrinol Diabetes
2010
Homo sapiens
Reddy, DN; Prasad, SS
Genetic basis of chronic pancreatitis in Asia Pacific region.
J Gastroenterol Hepatol
26 Suppl 2
2-5
2011
Homo sapiens
Masamune, A
Genetics of pancreatitis: the 2014 update.
Tohoku J Exp Med
232
69-77
2014
Homo sapiens
Binker, MG; Richards, D; Gaisano, HY; Cosen-Binker, LI
ER stress-associated CTRC mutants decrease stimulated pancreatic zymogen secretion through SIRT2-mediated microtubule dysregulation.
Biochem Biophys Res Commun
463
329-35
2015
Mus sp., Rattus
Takayama, K; Odagiri, M; Taguchi, A; Taniguchi, A; Hayashi, Y
Enzymatic Stability of Myostatin Inhibitory 16-mer Peptides.
Chem Pharm Bull (Tokyo)
68
512-515
2020
Homo sapiens
Gomis-Rüth, FX; Gómez-Ortiz, M; Vendrell, J; Ventura, S; Bode, W; Huber, R; Avilés, FX
Cutting at the right place--the importance of selective limited proteolysis in the activation of proproteinase E.
Eur J Biochem
251
839-44
1998
Bos taurus
Kang, MH
Genetic causes of chronic pancreatitis: the elucidation of genetic contributions to a disorder once thought to have none.
Clin Genet
73
424-425
2008
Jonas
Derikx, MH; Szmola, R; Te Morsche, RH; Sunderasan, S; Chacko, A; Drenth, JP
Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants.
Eur J Gastroenterol Hepatol
2009
Homo sapiens
Witt, H
Genetics of pancreatitis: a guide for clinicians.
Dig Dis
28
702-8
2010
Homo sapiens
Schnúr, A; Beer, S; Witt, H; Hegyi, P; Sahin-Tóth, M
Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis.
Gut
2013
Homo sapiens
Tomaiuolo, AC; Sofia, VM; Surace, C; Majo, F; Genovese, S; Petrocchi, S; Grotta, S; Alghisi, F; Lucidi, V; Angioni, A
Relationship between CFTR and CTRC Variants and the Clinical Phenotype in Late-Onset Cystic Fibrosis Disease with Chronic Pancreatitis.
J Mol Diagn
17
171-8
2015
Pierinae
Giefer, MJ; Lowe, ME; Werlin, SL; Zimmerman, B; Wilschanski, M; Troendle, D; Schwarzenberg, SJ; Pohl, JF; Palermo, J; Ooi, CY; Morinville, VD; Lin, TK; Husain, SZ; Himes, R; Heyman, MB; Gonska, T; Gariepy, CE; Freedman, SD; Fishman, DS; Bellin, MD; Barth, B; Abu-El-Haija, M; Uc, A
Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations.
J Pediatr
186
95-100
2017
Homo sapiens
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