Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 3.4.21.2 - chymotrypsin C

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Bone Resorption
Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function.
Determination of amino acid sequence responsible for suppression of bone resorption by serum calcium-decreasing factor (caldecrin).
Purification and Biological Function of Caldecrin.
Rat brain expresses serum calcium-decreasing factor (caldecrin).
Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling pathway.
Cystic Fibrosis
CFTR, SPINK1, PRSS1, and CTRC Mutations Are Not Associated With Pancreatic Cancer in German Patients.
Chronic pancreatitis associated with the p.G208A variant of PRSS1 gene in a European patient.
Comprehensive screening for PRSS1, SPINK1, CFTR, CTRC and CLDN2 gene mutations in Chinese paediatric patients with idiopathic chronic pancreatitis: a cohort study.
Environmental risk factors for chronic pancreatitis and pancreatic cancer.
Genetic and phenotypic heterogeneity in tropical calcific pancreatitis.
Genetic aspects of pancreatitis.
Genetic Evaluation of Children with Idiopathic Recurrent Acute Pancreatitis.
Genetics of acute and chronic pancreatitis: An update.
Targeted Gene Next-Generation Sequencing in Chinese Children with Chronic Pancreatitis and Acute Recurrent Pancreatitis.
Cysts
Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations.
Kidney Failure, Chronic
Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations.
Muscular Dystrophies
Serum Calcium-decreasing Factor, Caldecrin, Ameliorates Muscular Dystrophy in dy/dy Mice.
Neoplasms
Effect of chymotrypsin C and related proteins on pancreatic cancer cell migration.
Osteoarthritis
Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function.
Osteoporosis
Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function.
Pancreatic Neoplasms
CFTR, SPINK1, PRSS1, and CTRC Mutations Are Not Associated With Pancreatic Cancer in German Patients.
Effect of chymotrypsin C and related proteins on pancreatic cancer cell migration.
Pancreatitis
Chronic pancreatitis associated with the p.G208A variant of PRSS1 gene in a European patient.
Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen.
Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk.
Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants.
Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations.
Evaluation of the Pathogenic Significance of the Novel p.T58M Chymotrypsin C Variant in Recurrent Acute Pancreatitis.
Frequency of Tabagism and N34S and P55S Mutations of Serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) and R254W Mutation of Chymotrypsin C (CTRC) in Patients With Chronic Pancreatitis and Controls.
Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis.
Genetic basis of chronic pancreatitis in Asia Pacific region.
Genetic Evaluation of Children with Idiopathic Recurrent Acute Pancreatitis.
Genetics of pancreatitis: the 2014 update.
Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.
Multifactorial Genesis of Pancreatitis in Primary Hyperparathyroidism: Evidence for "Protective" (PRSS2) and "Destructive" (CTRC) Genetic Factors.
Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice.
Paediatric and hereditary aspects of chronic pancreatitis.
Relationship between CFTR and CTRC Variants and the Clinical Phenotype in Late-Onset Cystic Fibrosis Disease with Chronic Pancreatitis.
Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis-associated cationic trypsinogen mutants.
The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population.
Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis.
Pancreatitis, Alcoholic
Frequency of Tabagism and N34S and P55S Mutations of Serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) and R254W Mutation of Chymotrypsin C (CTRC) in Patients With Chronic Pancreatitis and Controls.
Pancreatitis, Chronic
Association of Novel Chymotrypsin C Gene Variations and Haplotypes in Patients with Chronic Pancreatitis in Chinese in Taiwan.
Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis.
CFTR, SPINK1, PRSS1, and CTRC Mutations Are Not Associated With Pancreatic Cancer in German Patients.
Chronic pancreatitis associated with the p.G208A variant of PRSS1 gene in a European patient.
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis.
Chymotrypsin C mutations in chronic pancreatitis.
Chymotrypsinogen C Genetic Variants, Including c.180TT, Are Strongly Associated With Chronic Pancreatitis in Pediatric Patients.
Clinical interpretation of SPINK1 and CTRC variants in pancreatitis.
Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants.
Frequency of Tabagism and N34S and P55S Mutations of Serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) and R254W Mutation of Chymotrypsin C (CTRC) in Patients With Chronic Pancreatitis and Controls.
Genetic aspects of pancreatitis.
Genetic causes of chronic pancreatitis: the elucidation of genetic contributions to a disorder once thought to have none.
Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.
Molecular basis for pancreatitis.
Mutational analysis of ATP8B1 in patients with chronic pancreatitis.
Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice.
Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells.
The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population.
Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants.
[Chronic pancreatitis]
Pulmonary Fibrosis
Serpina3n is closely associated with fibrotic procession and knockdown ameliorates bleomycin-induced pulmonary fibrosis.