Information on EC 3.4.21.121 - Lys-Lys/Arg-Xaa endopeptidase

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The expected taxonomic range for this enzyme is: Aeromonas sobria

EC NUMBER
COMMENTARY hide
3.4.21.121
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RECOMMENDED NAME
GeneOntology No.
Lys-Lys/Arg-Xaa endopeptidase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Cleavage of -Lys-Lys-/- and -Lys-Arg-/- bonds.
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Ac-Asp-Glu-Val-Asp-4-methylcoumaryl-7-amide + H2O
Ac-Asp-Glu-Val-Asp + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
release of 0.4 nM product per min
-
?
Boc-Arg-Val-Arg-Arg-4-methylcoumaryl-7-amide + H2O
Boc-Arg-Val-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Boc-Asp(OBzl)-Pro-Arg-4-methylcoumaryl-7-amide + H2O
Boc-Asp(OBzl)-Pro-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
release of 2.0 nM product per min
-
?
Boc-Glu(OBzl)-Ala-Arg-4-methylcoumaryl-7-amide + H2O
Boc-Glu(OBzl)-Ala-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
release of 1.8 nM product per min
-
?
Boc-Glu-Lys-Lys-4-methylcoumaryl-7-amide + H2O
Boc-Glu-Lys-Lys + 7-amino-4-methylcoumarin
show the reaction diagram
Boc-Gly-Arg-Arg-4-methylcoumaryl-7-amide + H2O
Boc-Gly-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
release of 1.0 nM product per min
-
?
Boc-Gly-Lys-Arg-4-methylcoumaryl-7-amide + H2O
Boc-Gly-Lys-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Boc-Ile-Glu-Gly-Arg-4-methylcoumaryl-7-amide + H2O
Boc-Ile-Glu-Gly-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
release of 64 nM product per min
-
?
Boc-Leu-Lys-Arg-4-methylcoumaryl-7-amide + H2O
Boc-Leu-Lys-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
release of 7.0 nM product per min
-
?
Boc-Leu-Ser-Thr-Arg-4-methylcoumaryl-7-amide + H2O
Boc-Leu-Ser-Thr-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
release of 45 nM product per min
-
?
Boc-Leu-Thr-Arg-4-methylcoumaryl-7-amide + H2O
Boc-Leu-Thr-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
release of 1.5 nM product per min
-
?
Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide + H2O
Boc-Phe-Ser-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
release of 2.2 nM product per min
-
?
Boc-Val-Leu-Lys-4-methylcoumaryl-7-amide + H2O
Boc-Val-Leu-Lys + 7-amino-4-methylcoumarin
show the reaction diagram
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-
release of 1.3 nM product per min
-
?
complement component C5 + H2O
complement component C5a + ?
show the reaction diagram
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-
-
-
?
Fibrinogen + H2O
?
show the reaction diagram
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-
-
-
?
Gly-Pro-4-methylcoumaryl-7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
release of 0.4 nM product per min
-
?
prekallikrein + H2O
?
show the reaction diagram
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-
-
-
?
prothrombin + H2O
alpha-thrombin + prothrombin fragments
show the reaction diagram
-
-
-
-
?
Pyr-Arg-Thr-Lys-Arg-4-methylcoumaryl-7-amide + H2O
Pyr-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
Suc(OMe)-Ala-Ala-Pro-Val-4-methylcoumaryl-7-amide + H2O
Suc(OMe)-Ala-Ala-Pro-Val + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
release of 1.2 nM product per min
-
?
Suc-Ala-Ala-Pro-Phe-4-methylcoumaryl-7-amide + H2O
Suc-Ala-Ala-Pro-Phe + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
release of 1.8 nM product per min
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?
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
alpha2-Macroglobulin
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-
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
65000
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SDS-PAGE
66640
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calculated from sequence
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
crystal strucutre at at 1.65 A resolution
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
EXPRESSED IN Vibrio parahaemolyticus
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