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Information on EC 3.4.21.112 - site-1 protease and Organism(s) Rattus norvegicus and UniProt Accession Q9WTZ3

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.112 site-1 protease
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This record set is specific for:
Rattus norvegicus
UNIPROT: Q9WTZ3 not found.
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3
Synonyms
ski-1, ski-1/s1p, site-1 protease, site 1 protease, pcsk8, hski-1, convertase site 1 protease, srebp site 1 protease, subtilisin kexin isozyme 1/site 1 protease, subtilisin-kexin isoenzyme-1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
S08.063
Merops ID
site-1 protease
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SKI-1/S1P
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subtilisin-kexin-isozyme
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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cleavage of C-N-linkage
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hydrolysis of peptide bond
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cleavage of C-N-linkage
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-
CAS REGISTRY NUMBER
COMMENTARY hide
167140-48-9
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
sterol regulatory element-binding protein + H2O
?
show the reaction diagram
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-
-
-
?
additional information
?
-
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can cleave postsingle and possibly pairs of Thr residues in certain precursors
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?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride
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-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
Uniprot
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
osteosarcoma cell line used. Mineralizing UMR 106 cells express a 98 kDa active, soluble form of SKI-1 within biomineralization foci. Non-mineralizing UMR cells differentially process SKI-1 into smaller immunoreactive fragments
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MBTP1_RAT
1052
1
117462
Swiss-Prot
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
35000
-
SDS-PAGE, predominant form in non-mineralizing cultures are smaller than 35 kDa
98000
-
SDS-PAGE, expressed as a soluble enzyme in mineralizing UMR 106 cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Seidah, N.G.; Benjannet, S.; Hamelin, J.; Mamarbachi, A.M.; Basak, A.; Marcinkiewicz, J.; Mbikay, M.; Chretien, M.; Marcinkiewicz, M.
The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1
Ann. N. Y. Acad. Sci.
885
57-74
1999
Rattus norvegicus
Manually annotated by BRENDA team
Seidah, N.G.; Mowla, S.J.; Hamelin, J.; Mamarbachi, A.M.; Benjannet, S.; Toure, B.B.; Basak, A.; Munzer, J.S.; Marcinkiewicz, J.; Zhong, M.; Barale, J.C.; Lazure, C.; Murphy, R.A.; Chretien, M.; Marcinkiewicz, M.
Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization
Proc. Natl. Acad. Sci. USA
96
1321-1326
1999
Homo sapiens, Rattus norvegicus (Q9WTZ3)
Manually annotated by BRENDA team
Seidah, N.G.; Chretien, M.
Proprotein convertase SKI-1/SIP
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press
2
1845-1847
2004
Arabidopsis thaliana, Cricetulus griseus, Homo sapiens, Mus musculus, Oryza sativa, Rattus norvegicus
-
Manually annotated by BRENDA team
Buraczewska, I.; Berne, B.; Lindberg, M.; Loden, M.; Toermae, H.
Long-term treatment with moisturizers affects the mRNA levels of genes involved in keratinocyte differentiation and desquamation
Arch. Dermatol. Res.
301
175-181
2009
Rattus norvegicus
Manually annotated by BRENDA team
Yellaturu, C.; Deng, X.; Park, E.; Raghow, R.; Elam, M.
Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptionaldown-regulation of insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP)SREBP-1c complex
J. Biol. Chem.
284
31726-31734
2009
Rattus norvegicus
Manually annotated by BRENDA team