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Disease on EC 3.4.21.108 - HtrA2 peptidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Kidney Injury
Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction.
Adenocarcinoma
Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer.
aldehyde dehydrogenase (nad+) deficiency
Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.
Alzheimer Disease
Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's disease.
HtrA2 interacts with A beta peptide but does not directly alter its production or degradation.
Immunohistochemical localization of X-linked inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies.
Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer's Disease Brain.
Localization of HtrA2/Omi immunoreactivity in brains affected by Alzheimer's disease.
Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells.
Amyotrophic Lateral Sclerosis
HtrA2/Omi-immunoreactive intraneuronal inclusions in the anterior horn of patients with sporadic and SOD1 mutant amyotrophic lateral sclerosis.
Brain Diseases
Omi/HtrA2 Protease Associated Cell Apoptosis Participates in Blood-Brain Barrier Dysfunction.
Omi/HtrA2 Regulates a Mitochondria-Dependent Apoptotic Pathway in a Murine Model of Septic Encephalopathy.
Brain Injuries
Translocation of the serine protease Omi/HtrA2 from mitochondria into the cytosol upon seizure-induced hippocampal injury in the neonatal rat brain.
UCF-101, a novel Omi/HtrA2 inhibitor, protects against cerebral ischemia/reperfusion injury in rats.
Brain Ischemia
Modulation of the Omi/HtrA2 signaling pathway after transient focal cerebral ischemia in mouse brains that overexpress SOD1.
The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion.
Carcinogenesis
Activation of apoptosis in hepatocellular carcinoma by the Chinese traditional medicine Hu Qisan.
Role of Smac, survivin, XIAP, and Omi/HtrA2 proteins in determining the chemotherapeutic response of patients with cervical cancer treated with neoadjuvant chemotherapy.
Carcinoma
Expression levels of the mitochondrial IAP antagonists Smac/DIABLO and Omi/HtrA2 in clear-cell renal cell carcinomas and their prognostic value.
Role of Smac, survivin, XIAP, and Omi/HtrA2 proteins in determining the chemotherapeutic response of patients with cervical cancer treated with neoadjuvant chemotherapy.
[Association of Omi/HtrA2 expression and prognosis in patients with gastric carcinoma.]
[The prognostic significance of Omi/HtrA2 expression, and correlation between Omi/HtrA2 and hypoxia-inducible factor-1? in primary hepatocelluar carcinoma cells].
Carcinoma, Hepatocellular
Hypoxia-inducible factor-1alpha suppressed hepatocellular carcinoma cell apoptosis through influencing on Omi/HtrA2 expression and its releasing from the mitochondrion.
Omi/HtrA2 pro-apoptotic marker differs in various hepatocellular carcinoma cell lines owing to ped/pea-15 expression level.
The Expression and Clinical Significance of Omi/Htra2 in Hepatocellular Carcinoma.
The expression and clinical significance of Omi/Htra2 in hepatocellular carcinoma.
Carcinoma, Renal Cell
Expression levels of the mitochondrial IAP antagonists Smac/DIABLO and Omi/HtrA2 in clear-cell renal cell carcinomas and their prognostic value.
Cardiomegaly
Response of caspase-independent apoptotic factors to high salt diet-induced heart failure.
Cerebral Hemorrhage
Increased expression of Apo-J and Omi/HtrA2 after Intracerebral Hemorrage in rats.
Colonic Neoplasms
Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria.
Participation of Omi Htra2 serine-protease activity in the apoptosis induced by cisplatin on SW480 colon cancer cells.
Cytomegalovirus Infections
HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA).
Deafness
Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis.
Dementia
Accumulation of HAX-1 and PARL in brainstem- and cortical-type Lewy bodies in Parkinson's disease and dementia with Lewy bodies.
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.
Immunohistochemical localization of X-linked inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies.
Dystonia
Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis.
endopeptidase la deficiency
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Essential Tremor
Mitochondrial serine protease HTRA2 gene mutation in Asians with coexistent essential tremor and Parkinson disease.
Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease.
Heart Failure
Response of caspase-independent apoptotic factors to high salt diet-induced heart failure.
htra2 peptidase deficiency
HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA.
Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.
Serine Protease HtrA2/Omi Deficiency Impairs Mitochondrial Homeostasis and Promotes Hepatic Fibrogenesis via Activation of Hepatic Stellate Cells.
Huntington Disease
Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.
Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease.
Infarction, Middle Cerebral Artery
Mitochondrial serine protease Omi/HtrA2 accentuates brain ischemia/reperfusion injury in rats and oxidative stress injury in vitro by modulating mitochondrial stress proteins CHOP and ClpP and physically interacting with mitochondrial fusion protein OPA1.
Infections
Activation of the extrinsic caspase pathway in cultured cortical neurons requires p53-mediated down-regulation of the X-linked inhibitor of apoptosis protein to induce apoptosis.
Multiplicity-dependent activation of a serine protease-dependent cytomegalovirus-associated programmed cell death pathway.
Infertility, Male
[Expression of Omi/HtrA2 UP-regulated in the spermatozoa of chronic bacterial prostatitis patients]
Leukemia
Can application of serine protease inhibitors TPCK and TLCK provide evidence for possible involvement of serine protease Omi/HtrA2 in imatinib mesylate-induced cell death of BCR-ABL-positive human leukemia cells?
Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK).
Leukemia, Lymphocytic, Chronic, B-Cell
Expression of AIF and HtrA2/Omi in small lymphocytic lymphoma and diffuse large B-cell lymphoma.
Liver Cirrhosis
Serine Protease HtrA2/Omi Deficiency Impairs Mitochondrial Homeostasis and Promotes Hepatic Fibrogenesis via Activation of Hepatic Stellate Cells.
Lung Neoplasms
[Inhibitory effect and the mechanism of Astragalus polysaccharide combined with cisplatin on growth of inplanted Lewis lung carcinoma in mice].
Lymphatic Metastasis
The Expression and Clinical Significance of Omi/Htra2 in Hepatocellular Carcinoma.
[Association of Omi/HtrA2 expression and prognosis in patients with gastric carcinoma.]
Lymphoma
Expression of AIF and HtrA2/Omi in small lymphocytic lymphoma and diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Expression of AIF and HtrA2/Omi in small lymphocytic lymphoma and diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Expression of AIF and HtrA2/Omi in small lymphocytic lymphoma and diffuse large B-cell lymphoma.
Melanoma
Proteolytic cleavage of Livin (ML-IAP) in apoptotic melanoma cells potentially mediated by a non-canonical caspase.
Movement Disorders
Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response.
Multiple Myeloma
Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi.
Myocardial Ischemia
Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion.
Neoplasm Metastasis
The Expression and Clinical Significance of Omi/Htra2 in Hepatocellular Carcinoma.
[Association of Omi/HtrA2 expression and prognosis in patients with gastric carcinoma.]
Neoplasms
Excessive mitochondrial fragmentation triggered by erlotinib promotes pancreatic cancer PANC-1 cell apoptosis via activating the mROS-HtrA2/Omi pathways.
Expression levels of the mitochondrial IAP antagonists Smac/DIABLO and Omi/HtrA2 in clear-cell renal cell carcinomas and their prognostic value.
HtrA2, taming the oncogenic activities of WT1.
Hypoxia-inducible factor-1alpha suppressed hepatocellular carcinoma cell apoptosis through influencing on Omi/HtrA2 expression and its releasing from the mitochondrion.
Immunohistochemical analysis of Omi/HtrA2 expression in prostate cancer and benign prostatic hyperplasia.
Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer.
Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer.
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways.
Mitochondrial proteases and cancer.
Omi/HtrA2 pro-apoptotic marker differs in various hepatocellular carcinoma cell lines owing to ped/pea-15 expression level.
Simvastatin Alleviates Intestinal Ischemia/Reperfusion Injury by Modulating Omi/HtrA2 Signaling Pathways.
Staurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway.
Temperature-induced changes of HtrA2(Omi) protease activity and structure.
The Expression and Clinical Significance of Omi/Htra2 in Hepatocellular Carcinoma.
Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization.
YAP Inhibits the Apoptosis and Migration of Human Rectal Cancer Cells via Suppression of JNK-Drp1-Mitochondrial Fission-HtrA2/Omi Pathways.
[Association of Omi/HtrA2 expression and prognosis in patients with gastric carcinoma.]
[Inhibitory effect and the mechanism of Astragalus polysaccharide combined with cisplatin on growth of inplanted Lewis lung carcinoma in mice].
Neuroblastoma
Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi.
Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells.
Neurodegenerative Diseases
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.
Association of Omi/HtrA2 with ?-secretase in mitochondria.
Deficiency of HTRA2/Omi is associated with infantile neurodegeneration and 3-methylglutaconic aciduria.
HtrA2/Omi, a sheep in wolf's clothing.
Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer.
Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases.
Pathogenic Role of Serine Protease HtrA2/Omi in Neurodegenerative Diseases.
Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells.
Temperature-induced changes of HtrA2(Omi) protease activity and structure.
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.
The mitochondrial serine protease HtrA2/Omi: an overview.
Optic Atrophy
Mitochondrial serine protease Omi/HtrA2 accentuates brain ischemia/reperfusion injury in rats and oxidative stress injury in vitro by modulating mitochondrial stress proteins CHOP and ClpP and physically interacting with mitochondrial fusion protein OPA1.
Ovarian Neoplasms
Regulation of HtrA2/Omi by X-linked inhibitor of apoptosis protein in chemoresistance in human ovarian cancer cells.
Parkinson Disease
A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease.
Accumulation of HAX-1 and PARL in brainstem- and cortical-type Lewy bodies in Parkinson's disease and dementia with Lewy bodies.
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.
Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's disease.
Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin.
Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease.
Genetic variation of Omi/HtrA2 and Parkinson's disease.
Genetic variations of Omi/HTRA2 in Chinese patients with Parkinson's disease.
Genetics of Parkinson disease and essential tremor.
Immunohistochemical localization of X-linked inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies.
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.
Loss of GSK-3? mediated phosphorylation in HtrA2 contributes to uncontrolled cell death with Parkinsonian phenotype.
Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo.
Matrix metalloproteinase-3 is activated by HtrA2/Omi in dopaminergic cells: Relevance to Parkinson's disease.
Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.
Mitochondrial serine protease HTRA2 gene mutation in Asians with coexistent essential tremor and Parkinson disease.
Mitochondrial Serine Protease HTRA2 p.G399S in a Female with Di George Syndrome and Parkinson's Disease.
Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease.
Novel variant Pro143Ala in HTRA2 contributes to Parkinson's disease by inducing hyperphosphorylation of HTRA2 protein in mitochondria.
Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.
Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin.
Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls.
The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi.
The HtrA2 Drosophila model of Parkinson's disease is suppressed by the pro-survival Bcl-2 Buffy.
The mitochondrial serine protease HtrA2/Omi: an overview.
The yeast HtrA orthologue Ynm3 is a protease with chaperone activity that aids survival under heat stress.
Parkinsonian Disorders
The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi.
Peripheral Nervous System Diseases
Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi.
Progeria
Omi/HtrA2 Participates in Age-Related Autophagic Deficiency in Rat Liver.
Prostatic Hyperplasia
Immunohistochemical analysis of Omi/HtrA2 expression in prostate cancer and benign prostatic hyperplasia.
Prostatic Neoplasms
Immunohistochemical analysis of Omi/HtrA2 expression in prostate cancer and benign prostatic hyperplasia.
Integrin alpha 7 interacts with high temperature requirement A2 (HtrA2) to induce prostate cancer cell death.
The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2.
[Effects of Omi/HtrA2 on expression of anti-apoptotic protein PED/PEA-15 and apoptosis of prostate cancer cell line PC-3]
Prostatitis
Reduced semen quality in chronic prostatitis patients that induce the release of apoptotic protein Omi/HtrA2 from spermatozoa.
Retraction: Reduced semen quality in chronic prostatitis patients that induce the release of apoptotic protein Omi/HtrA2 from spermatozoa.
[Expression of Omi/HtrA2 UP-regulated in the spermatozoa of chronic bacterial prostatitis patients]
Rectal Neoplasms
YAP Inhibits the Apoptosis and Migration of Human Rectal Cancer Cells via Suppression of JNK-Drp1-Mitochondrial Fission-HtrA2/Omi Pathways.
Renal Insufficiency
Acute renal failure in zebrafish: a novel system to study a complex disease.
Retinal Degeneration
The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi.
Sarcopenia
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Status Epilepticus
Translocation of the serine protease Omi/HtrA2 from mitochondria into the cytosol upon seizure-induced hippocampal injury in the neonatal rat brain.
Stomach Neoplasms
Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer.
[Association of Omi/HtrA2 expression and prognosis in patients with gastric carcinoma.]
Synucleinopathies
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.
Ureteral Obstruction
Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction.
Uterine Cervical Neoplasms
Role of Smac, survivin, XIAP, and Omi/HtrA2 proteins in determining the chemotherapeutic response of patients with cervical cancer treated with neoadjuvant chemotherapy.
Warts
Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation.
Wilms Tumor
The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi.