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Disease on EC 3.4.21.107 - peptidase Do

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis, Lactic
Monogenic cerebral small-vessel diseases: diagnosis and therapy. Consensus recommendations of the European Academy of Neurology.
Adenocarcinoma
Ovarian serous carcinomas acquire cisplatin resistance and increased invasion through downregulation of the high-temperature-required protein A2 (HtrA2), following repeated treatment with cisplatin.
Adenocarcinoma of Lung
HtrA1 Downregulation Induces Cisplatin Resistance in Lung Adenocarcinoma by Promoting Cancer Stem Cell-Like Properties.
Long intergenic non?coding RNA 00467 promotes lung adenocarcinoma proliferation, migration and invasion by binding with EZH2 and repressing HTRA3 expression.
Adenocarcinoma, Follicular
Changes in expression of human serine protease HtrA1, HtrA2 and HtrA3 genes in benign and malignant thyroid tumors.
Adenoma
Low HtrA1 expression in patients with long?standing ulcerative colitis and colorectal cancer.
Aggressive Periodontitis
The novel role of HtrA1 in gingivitis, chronic and aggressive periodontitis.
Alopecia
A novel mutation in the HTRA1 gene causes CARASIL without alopecia.
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL): from discovery to gene identification.
Two novel HTRA1 mutations in a European CARASIL patient.
[Carasil].
[Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL)].
[Clinical manifestations and neuroradiological findings of CARASIL with a novel mutation].
Alzheimer Disease
A New Function of Human HtrA2 as an Amyloid-beta Oligomerization Inhibitor.
HtrA protease family as therapeutic targets.
HtrA1: a novel regulator of physiological and pathological matrix mineralization?
HtrA1: Its future potential as a novel biomarker for cancer.
Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening.
Pathogenic Role of Serine Protease HtrA2/Omi in Neurodegenerative Diseases.
Rs2293871 regulates HTRA1 expression and affects cerebral small vessel stroke and Alzheimer's disease.
Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease.
Amyloidosis
The serine protease HtrA1 cleaves misfolded transforming growth factor ?-induced protein (TGFBIp) and induces amyloid formation.
Arthritis
Anti-rheumatoid arthritis effects in adjuvant-induced arthritis in rats and molecular docking studies of Polygonum orientale L. extracts.
Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis.
HtrA2 is required for inflammatory responses in BMDMs via controlling TRAF2 stability in collagen-induced arthritis.
HtrA2 suppresses autoimmune arthritis and regulates activation of STAT3.
Molecular structure and the role of high-temperature requirement protein 1 in skeletal disorders and cancers.
The role of human HtrA1 in arthritic disease.
Arthritis, Experimental
HtrA2 is required for inflammatory responses in BMDMs via controlling TRAF2 stability in collagen-induced arthritis.
LPS increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA1 expression.
The inhibitory effect of IFN-? on protease HTRA1 expression in rheumatoid arthritis.
Arthritis, Rheumatoid
LPS increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA1 expression.
The inhibitory effect of IFN-? on protease HTRA1 expression in rheumatoid arthritis.
[Association study on single nucleotide polymorphisms in HTRA1 gene and rheumatoid arthritis]
Ataxia
Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.
Blindness
Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-? signaling.
Brain Diseases
Monogenic cerebral small-vessel diseases: diagnosis and therapy. Consensus recommendations of the European Academy of Neurology.
Omi/HtrA2 Regulates a Mitochondria-Dependent Apoptotic Pathway in a Murine Model of Septic Encephalopathy.
Brain Injuries
BMP-responsive Protease HtrA1 is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury Response.
Brain Ischemia
Specific Alterations of the HtrA2/HAX-1 Ratio in the Penumbra Upon Focal Cerebral Ischemia in Mice.
The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia.
Brain Neoplasms
HtrA4 Protease Promotes Chemotherapeutic-Dependent Cancer Cell Death.
Breast Neoplasms
Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways.
Downregulation of serine protease HTRA1 is associated with poor survival in breast cancer.
Genetic Variation in IGF2 and HTRA1 and Breast Cancer Risk among BRCA1 and BRCA2 Carriers.
HTRA1 gene expression in gastric epithelial cells.
HtrA1 loss is related to aggressive behavior parameters in sentinel node positive breast cancer.
HtrA3 is negatively correlated with lymph node metastasis in invasive ductal breast cancer.
HtrA4 Protease Promotes Chemotherapeutic-Dependent Cancer Cell Death.
Role of ALDH1A1 and HTRA2 expression in CCL2/CCR2-mediated breast cancer cell growth and invasion.
Tumor slices as a model to evaluate doxorubicin in vitro treatment and expression of trios of genes PRSS11, MTSS1, CLPTM1 and PRSS11, MTSS1, SMYD2 in canine mammary gland cancer.
CADASIL
A Next-Generation Sequencing of the NOTCH3 and HTRA1 Genes in CADASIL Patients.
Blood biomarkers in a mouse model of CADASIL.
CADASIL brain vessels show a HTRA1 loss-of-function profile.
Heterozygous mutations of HTRA1 gene in patients with familial cerebral small vessel disease.
Novel and Recurring NOTCH3 Mutations in Two Chinese Patients with CADASIL.
Carcinogenesis
Cellular substrates and pro-apoptotic function of the human HtrA4 protease.
Changes in expression of human serine protease HtrA1, HtrA2 and HtrA3 genes in benign and malignant thyroid tumors.
Epigenetic silencing of serine protease HTRA1 drives polyploidy.
Expression of HTRA Genes and Its Association with Microsatellite Instability and Survival of Patients with Colorectal Cancer.
HtrA1 as a promising tissue marker in cancer: a meta-analysis.
HtrA1 Downregulation Induces Cisplatin Resistance in Lung Adenocarcinoma by Promoting Cancer Stem Cell-Like Properties.
HtrA4 Protease Promotes Chemotherapeutic-Dependent Cancer Cell Death.
Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas.
Molecular structure and the role of high-temperature requirement protein 1 in skeletal disorders and cancers.
The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease.
[Frequent epigenetic inactivation of XAF1 by promotor hypermethylation in human colon cancers]
Carcinoma
Changes in expression of human serine protease HtrA1, HtrA2 and HtrA3 genes in benign and malignant thyroid tumors.
Correction to: HtrA1 expression and the prognosis of high-grade serous ovarian carcinoma: a cohort study using digital analysis.
Elevated serine protease HtrA1 inhibits cell proliferation, reduces invasion, and induces apoptosis in esophageal squamous cell carcinoma by blocking the nuclear factor-?B signaling pathway.
Epigenetic silencing of serine protease HTRA1 drives polyploidy.
HtrA1 expression and the prognosis of high-grade serous ovarian carcinoma: a cohort study using digital analysis.
HtrA1 expression associated with the occurrence and development of esophageal cancer.
HTRA1 gene expression in gastric epithelial cells.
HtrA1 in human urothelial bladder cancer: A secreted protein and a potential novel biomarker.
HtrA3 is regulated by 15-deoxy-Delta12,14-prostaglandin J2 independently of PPARgamma in clear cell renal cell carcinomas.
Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas.
[Expression levels of the IAP antagonists XAF1, Smac/DIABLO and HtrA2 in testicular germ cell tumours]
Carcinoma in Situ
[Expression levels of the IAP antagonists XAF1, Smac/DIABLO and HtrA2 in testicular germ cell tumours]
Carcinoma, Hepatocellular
HtrA1 regulates Epithelial-mesenchymal transition in hepatocellular carcinoma.
HtrA1 resensitizes multidrug-resistant hepatocellular carcinoma cells by targeting XIAP.
Hypoxia-inducible factor-1alpha suppressed hepatocellular carcinoma cell apoptosis through influencing on Omi/HtrA2 expression and its releasing from the mitochondrion.
Serine protease HtrA1 expression in human hepatocellular carcinoma.
The expression of HtrA2 and its diagnostic value in patients with hepatocellular carcinoma.
Carcinoma, Intraductal, Noninfiltrating
Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways.
Carcinoma, Non-Small-Cell Lung
Antagonism between HTRA3 and TGF?1 Contributes to Metastasis in Non-Small Cell Lung Cancer.
Carcinoma, Ovarian Epithelial
Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells.
HTRA3 is reduced in ovarian cancers regardless of stage.
Carcinoma, Renal Cell
HtrA3 is regulated by 15-deoxy-Delta12,14-prostaglandin J2 independently of PPARgamma in clear cell renal cell carcinomas.
Cardiotoxicity
Matricellular protein CCN1 mediates doxorubicin-induced cardiomyopathy in mice.
Cardiovascular Diseases
Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury.
Central Nervous System Diseases
The member of high temperature requirement family HtrA2 participates in neuronal apoptosis after intracerebral hemorrhage in adult rats.
Cerebral Hemorrhage
Characterization of Heterozygous HTRA1 Mutations in Taiwanese Patients With Cerebral Small Vessel Disease.
The member of high temperature requirement family HtrA2 participates in neuronal apoptosis after intracerebral hemorrhage in adult rats.
Cerebral Infarction
Histopathologic features of an autopsied patient with cerebral small vessel disease and a heterozygous HTRA1 mutation.
Cerebral Small Vessel Diseases
A Case of Cerebral Small Vessel Disease Related to a Heterozygous Nonsense Mutation in HTRA1.
A novel heterozygous HTRA1 mutation is associated with autosomal dominant hereditary cerebral small vessel disease.
Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects.
Autosomal Dominant Cerebral Small Vessel Disease in HTRA1 Gene Mutation.
Cerebral small vessel disease caused by a novel heterozygous mutation in HTRA1.
Cerebral small vessel disease due to a unique heterozygous HTRA1 mutation in an African man.
Characterization of Heterozygous HTRA1 Mutations in Taiwanese Patients With Cerebral Small Vessel Disease.
Clinicoradiographic and genetic features of cerebral small vessel disease indicate variability in mode of inheritance for monoallelic HTRA1 variants.
Genotype-phenotype correlations of heterozygous HTRA1-related cerebral small vessel disease: case report and systematic review.
Heterozygous HTRA1 missense mutation in CADASIL-like family disease.
Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease.
Heterozygous HTRA1 nonsense or frameshift mutations are pathogenic.
Heterozygous mutations of HTRA1 gene in patients with familial cerebral small vessel disease.
Histopathologic Analysis of Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL): A Report of a New Genetically Confirmed Case and Comparison to 2 Previous Cases.
Histopathologic features of an autopsied patient with cerebral small vessel disease and a heterozygous HTRA1 mutation.
HTRA1 expression profile and activity on TGF-? signaling in HTRA1 mutation carriers.
HTRA1-related autosomal dominant cerebral small vessel disease.
HTRA1-Related Cerebral Small Vessel Disease: A Review of the Literature.
Novel Heterozygous HTRA1 Pathogenic Variant Found in a Chinese Family with Autosomal Dominant Cerebral Small Vessel Disease.
Two novel heterozygous HTRA1 mutations in two pedigrees with cerebral small vessel disease families.
Two Unique Mutations in HTRA1-Related Cerebral Small Vessel Disease in North America and Africa and Literature Review.
Unusual case of cerebral small vessel disease with a heterozygous nonsense mutation in HTRA1.
Cerebrovascular Disorders
HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication.
Choriocarcinoma
Expression pattern alterations of the serine protease HtrA1 in normal human placental tissues and in gestational trophoblastic diseases.
Inhibition of HTRA3 stimulates trophoblast invasion during human placental development.
Choroidal Neovascularization
ARMS2/HTRA1 and CFH polymorphisms are not associated with choroidal neovascularization in highly myopic eyes of the elderly Japanese population.
Binding of Gtf2i-?/? transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in vitro.
HTRA1 and TGF-?1 Concentrations in the Aqueous Humor of Patients With Neovascular Age-Related Macular Degeneration.
Overexpression of HtrA1 and exposure to mainstream cigarette smoke leads to choroidal neovascularization and subretinal deposits in aged mice.
Chronic Periodontitis
The novel role of HtrA1 in gingivitis, chronic and aggressive periodontitis.
Colitis
Inhibition of HtrA2 alleviated dextran sulfate sodium (DSS)-induced colitis by preventing necroptosis of intestinal epithelial cells.
Colitis, Ulcerative
Low HtrA1 expression in patients with long?standing ulcerative colitis and colorectal cancer.
Colonic Neoplasms
Effect of HtrA1 Polymorphism on Sensitivity to Chemotherapy in Patients with Colon Cancer.
Epigenetic silencing of serine protease HTRA1 drives polyploidy.
HtrA1 Down-regulation Induces Cisplatin Resistance in Colon Cancer by Increasing XIAP and Activating PI3K/Akt Pathway.
Participation of Omi Htra2 serine-protease activity in the apoptosis induced by cisplatin on SW480 colon cancer cells.
Colorectal Neoplasms
Expression of HTRA Genes and Its Association with Microsatellite Instability and Survival of Patients with Colorectal Cancer.
HtrA3 stromal expression is correlated with tumor budding in stage II colorectal cancer.
Low HtrA1 expression in patients with long?standing ulcerative colitis and colorectal cancer.
Screening for susceptibility genes in hereditary non-polyposis colorectal cancer.
Communicable Diseases
Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?
Corneal Dystrophies, Hereditary
Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies.
Proteomic Analysis of Amyloid Corneal Aggregates from TGFBI-H626R Lattice Corneal Dystrophy Patient Implicates Serine-Protease HTRA1 in Mutation-Specific Pathogenesis of TGFBIp.
The serine protease HtrA1 cleaves misfolded transforming growth factor ?-induced protein (TGFBIp) and induces amyloid formation.
Coronary Disease
Do protease inhibitors increase the risk for coronary heart disease in patients with HIV-1 infection?
Generation and characterization of mice with a conditional null allele of the HtrA4 gene.
Craniofacial Abnormalities
A CARASIL Patient from Americas with Novel Mutation and Atypical Features: Case Presentation and Literature Review.
Craniosynostoses
Effects of thyroxine exposure on osteogenesis in mouse calvarial pre-osteoblasts.
Cryptorchidism
HtrA2 is up-regulated in the rat testis after experimental cryptorchidism.
Cystadenocarcinoma, Serous
HtrA3 Is Downregulated in Cancer Cell Lines and Significantly Reduced in Primary Serous and Granulosa Cell Ovarian Tumors.
Cystic Fibrosis
Two distinct loci affecting conversion to mucoidy in Pseudomonas aeruginosa in cystic fibrosis encode homologs of the serine protease HtrA.
Cystitis
HtrA1 in human urothelial bladder cancer: A secreted protein and a potential novel biomarker.
Cysts
HtrA3 Is Downregulated in Cancer Cell Lines and Significantly Reduced in Primary Serous and Granulosa Cell Ovarian Tumors.
Deafness
Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing.
Dementia
Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3.
Mutation Analysis of the Genes Associated with Parkinson's Disease in a Finnish Cohort of Early-Onset Dementia.
Diverticulitis, Colonic
Low HtrA1 expression in patients with long?standing ulcerative colitis and colorectal cancer.
Dwarfism
Osteoarthritis-like changes in the heterozygous sedc mouse associated with the HtrA1-Ddr2-Mmp-13 degradative pathway: a new model of osteoarthritis.
Dystonia
HTRA2 p.G399S in Parkinson disease, essential tremor, and tremulous cervical dystonia.
Embolism
Melatonin ameliorates ischemic-like injury-evoked nitrosative stress: Involvement of HtrA2/PED pathways in endothelial cells.
Endometrial Hyperplasia
Hypoxia is involved in the reduction of HtrA3 in patients with endometrial hyperplasia and cancer.
Endometrial Neoplasms
Expression and functional significance of HtrA1 loss in endometrial cancer.
Expression of human HtrA1, HtrA2, HtrA3 and TGF-beta1 genes in primary endometrial cancer.
Hypoxia is involved in the reduction of HtrA3 in patients with endometrial hyperplasia and cancer.
Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer.
Endometriosis
Deregulation of LOXL1 and HTRA1 gene expression in endometriosis.
High temperature requirement A1, transforming growth factor beta1, phosphoSmad2 and Ki67 in eutopic and ectopic endometrium of women with endometriosis.
Enterocolitis
The role of serine protease HtrA in acute ulcerative enterocolitis and extra-intestinal immune responses during Campylobacter jejuni infection of gnotobiotic IL-10 deficient mice.
Esophageal Neoplasms
HtrA1 expression associated with the occurrence and development of esophageal cancer.
Esophageal Squamous Cell Carcinoma
Elevated serine protease HtrA1 inhibits cell proliferation, reduces invasion, and induces apoptosis in esophageal squamous cell carcinoma by blocking the nuclear factor-?B signaling pathway.
Essential Tremor
A step toward essential tremor gene discovery: identification of extreme phenotype and screening of HTRA2 and ANO3.
Genetic testing of FUS, HTRA2, and TENM4 genes in Chinese patients with essential tremor.
HTRA2 p.G399S in Parkinson disease, essential tremor, and tremulous cervical dystonia.
Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease.
Exanthema
Deregulation of LOXL1 and HTRA1 gene expression in endometriosis.
Eye Diseases
HTRA1, an age-related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1.
Fabry Disease
Monogenic cerebral small-vessel diseases: diagnosis and therapy. Consensus recommendations of the European Academy of Neurology.
Fetal Growth Retardation
Abnormal development of placenta in HtrA1-deficient mice.
Alterations of maternal plasma HTRA1 level in preeclampsia complicated by IUGR.
Expression patterns of two serine protease HtrA1 forms in human placentas complicated by preeclampsia with and without intrauterine growth restriction.
High temperature requirement A1 in placental tissues and serum from pre-eclamptic pregnancies with or without fetal growth restriction.
Frontotemporal Dementia
Monogenic Parkinson's disease and parkinsonism: Clinical phenotypes and frequencies of known mutations.
Ganglioneuroblastoma
Expression and localization of serine protease Htra1 in neuroblastoma: correlation with cellular differentiation grade.
Genetic Diseases, Inborn
Histopathologic Analysis of Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL): A Report of a New Genetically Confirmed Case and Comparison to 2 Previous Cases.
Geographic Atrophy
HTRA1 variant confers similar risks to geographic atrophy and neovascular age-related macular degeneration.
Joint effects of polymorphisms in the HTRA1, LOC387715/ARMS2, and CFH genes on AMD in a Caucasian population.
Nonclinical Safety Assessment of FHTR2163, An Antigen-Binding Fragment Against HTRA1 for the Treatment of Geographic Atrophy.
Phase I Study of the Anti-HtrA1 Antibody-Binding Fragment FHTR2163 in Geographic Atrophy Secondary to Age-Related Macular Degeneration.
Gestational Trophoblastic Disease
Expression pattern alterations of the serine protease HtrA1 in normal human placental tissues and in gestational trophoblastic diseases.
Gingivitis
The novel role of HtrA1 in gingivitis, chronic and aggressive periodontitis.
Glaucoma
Regulation of the HTRA2 Protease Activity by an Inhibitory Antibody-Derived Peptide Ligand and the Influence on HTRA2-Specific Protein Interaction Networks in Retinal Tissues.
Glioma
Expression of insulin-like growth factor binding protein genes and its hypoxic regulation in U87 glioma cells depends on ERN1 mediated signaling pathway of endoplasmic reticulum stress.
Glomerulonephritis, Membranous
Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy.
Glucose Intolerance
Expression of genes encoding IGF1, IGF2, and IGFBPs in blood of obese adolescents with insulin resistance.
Granulosa Cell Tumor
High-temperature requirement factor A3 (Htra3): a novel serine protease and its potential role in ovarian function and ovarian cancers.
HtrA3 Is Downregulated in Cancer Cell Lines and Significantly Reduced in Primary Serous and Granulosa Cell Ovarian Tumors.
Hearing Loss
Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing.
Hearing Loss, Sensorineural
Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing.
Huntington Disease
Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice.
Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease.
Hydatidiform Mole
Expression pattern alterations of the serine protease HtrA1 in normal human placental tissues and in gestational trophoblastic diseases.
Hyperlipidemias
HtrA2 suppresses autoimmune arthritis and regulates activation of STAT3.
Hypertension
Changes in the Level of Serum High-Temperature Requirement A1 (HtrA1) during Pregnancy and Its Relationship to Preeclampsia.
HTRA1 Variants and the Interaction with Smoking Confer the Genetic Susceptibility to Ischemic Stroke.
Serum HtrA1 is differentially regulated between early-onset and late-onset preeclampsia.
Hypertension, Pregnancy-Induced
Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth.
Infections
Chlamydia infection status, genotype, and age-related macular degeneration.
Cloning, expression and characterisation of an HtrA-like serine protease produced in vivo by Mycobacterium leprae.
Contribution of the serine protease HtrA in Escherichia coli to infection in foxes.
Expression analysis of proteases of Mycobacterium leprae in human skin lesions.
Knockdown of Litopenaeus vannamei HtrA2, an up-regulated gene in response to WSSV infection, leading to delayed shrimp mortality.
Protease Activity of Campylobacter jejuni HtrA Modulates Distinct Intestinal and Systemic Immune Responses in Infected Secondary Abiotic IL-10 Deficient Mice.
Re-examination of the role of the Brucella melitensis HtrA stress response protease in virulence in pregnant goats.
Secreted enzymatic activities of wild-type and pilD-deficient Legionella pneumophila.
The impact of serine protease HtrA in apoptosis, intestinal immune responses and extra-intestinal histopathology during Campylobacter jejuni infection of infant mice.
The novel role of HtrA1 in gingivitis, chronic and aggressive periodontitis.
The role of serine protease HtrA in acute ulcerative enterocolitis and extra-intestinal immune responses during Campylobacter jejuni infection of gnotobiotic IL-10 deficient mice.
Insulin Resistance
Expression of genes encoding IGF1, IGF2, and IGFBPs in blood of obese adolescents with insulin resistance.
Intervertebral Disc Degeneration
Association of HTRA1 promoter polymorphism with spinal disc degeneration in Japanese women.
Chondroadherin fragmentation mediated by the protease HTRA1 distinguishes human intervertebral disc degeneration from normal aging.
Correlation Between Expression of High Temperature Requirement Serine Protease A1 (HtrA1) in Nucleus Pulposus and T2 Value of Magnetic Resonance Imaging.
Correlation between the Expression of High Temperature Requirement Serine Protease A1 in Nucleus Pulposus Tissue and the Degree of Intervertebral Disc Degeneration.
HtrA1 up-regulates expression of MMPs via Erk1/2/Rock-dependent pathways.
The Emerging Roles of HTRA1 in Musculoskeletal Disease.
Ischemic Stroke
Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects.
HTRA1 Variants and the Interaction with Smoking Confer the Genetic Susceptibility to Ischemic Stroke.
Joint Diseases
Identification of a Novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo.
Keloid
High temperature requirement factor A1 (HTRA1) regulates the activation of latent TGF-?1 in keloid fibroblasts.
HtrA1 Is Specifically Up-Regulated in Active Keloid Lesions and Stimulates Keloid Development.
Leprosy
Cloning, expression and characterisation of an HtrA-like serine protease produced in vivo by Mycobacterium leprae.
Leukemia
Meeting Report:The 7th ESPE Growth Plate Working Group Symposium - EUROGROP June 27th 2007, Helsinki, Finland.
New Thalidomide-Resembling Dicarboximides Target ABC50 Protein and Show Antileukemic and Immunomodulatory Activities.
[Expression and Significance of X-linked Inhibitor of Apoptosis Protein and Its Antagonized Proteins in Acute Leukemia.]
[Expression of HtrA2 and WT1 Genes in Acute Myeloid Leukemia].
Leukemia, Myeloid, Acute
[Expression of HtrA2 and WT1 Genes in Acute Myeloid Leukemia].
Leukodystrophy, Metachromatic
Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3.
Leukoencephalopathies
A Case of Cerebral Small Vessel Disease Related to a Heterozygous Nonsense Mutation in HTRA1.
A Case of Leukoencephalopathy and Small Vessels Disease Caused by a Novel HTRA1 Homozygous Mutation.
A Next-Generation Sequencing of the NOTCH3 and HTRA1 Genes in CADASIL Patients.
A novel mutation of the high-temperature requirement A serine peptidase 1 (HTRA1) gene in a Chinese family with cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL).
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL).
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL): from discovery to gene identification.
Cerebral small vessel disease due to a unique heterozygous HTRA1 mutation in an African man.
Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-{beta}1 via cleavage of proTGF-{beta}1.
Distinct molecular mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL.
Evaluation of progressive multifocal leukoencephalopathy treatments in a Spanish cohort of HIV-infected patients: do protease inhibitors improve survival regardless of central nervous system penetration-effectiveness (CPE) score?
Genotype-phenotype correlations of heterozygous HTRA1-related cerebral small vessel disease: case report and systematic review.
Heterozygous HTRA1 mutations with mimicking symptoms of CARASIL in two families.
Histopathologic Analysis of Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL): A Report of a New Genetically Confirmed Case and Comparison to 2 Previous Cases.
Histopathologic features of an autopsied patient with cerebral small vessel disease and a heterozygous HTRA1 mutation.
How common are single gene mutations as a cause for lacunar stroke? A targeted gene panel study.
HTRA1 expression profile and activity on TGF-? signaling in HTRA1 mutation carriers.
HTRA1 Mutations Identified in Symptomatic Carriers Have the Property of Interfering the Trimer-Dependent Activation Cascade.
Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity.
Loss of HtrA1 serine protease induces synthetic modulation of aortic vascular smooth muscle cells.
Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3.
Monogenic cerebral small-vessel diseases: diagnosis and therapy. Consensus recommendations of the European Academy of Neurology.
Novel mutation in HTRA1 in a family with diffuse white matter lesions and inflammatory features.
Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease.
Shifting the CARASIL Paradigm: Report of a Non-Asian Family and Literature Review.
The first Greek case of heterozygous cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy: An atypical clinico-radiological presentation.
Two novel HTRA1 mutations in a European CARASIL patient.
Two Unique Mutations in HTRA1-Related Cerebral Small Vessel Disease in North America and Africa and Literature Review.
[Carasil].
[Consideration of the pathogenesis of CARASIL].
[Molecular pathogenesis of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy]
Leukoencephalopathy, Progressive Multifocal
Evaluation of progressive multifocal leukoencephalopathy treatments in a Spanish cohort of HIV-infected patients: do protease inhibitors improve survival regardless of central nervous system penetration-effectiveness (CPE) score?
Lung Neoplasms
Analysis of HtrA1 serine protease expression in human lung cancer.
Antagonism between HTRA3 and TGF?1 Contributes to Metastasis in Non-Small Cell Lung Cancer.
High temperature requirement A3 (HTRA3) expression predicts postoperative recurrence and survival in patients with non-small-cell lung cancer.
High temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines.
Methylation induced gene silencing of HtrA3 in smoking-related lung cancer.
The expression levels and prognostic value of high temperature required A2 (HtrA2) in NSCLC.
The HtrA3 protease promotes drug-induced death of lung cancer cells by cleavage of the X-linked inhibitor of apoptosis protein (XIAP).
Lyme Disease
Evaluation of Borrelia burgdorferi BbHtrA Protease as a Vaccine Candidate for Lyme Borreliosis in Mice.
The salt-sensitive structure and zinc inhibition of Borrelia burgdorferi protease BbHtrA.
Lymphatic Metastasis
Analysis of HtrA1 serine protease expression in human lung cancer.
Elevated serine protease HtrA1 inhibits cell proliferation, reduces invasion, and induces apoptosis in esophageal squamous cell carcinoma by blocking the nuclear factor-?B signaling pathway.
HtrA1 expression associated with the occurrence and development of esophageal cancer.
HtrA3 is negatively correlated with lymph node metastasis in invasive ductal breast cancer.
The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells.
Lymphoma
Resistance of Hematopoietic Progenitors to Fas-Mediated Apoptosis Is Actively Sustained by NF?B with a Characteristic Transcriptional Signature.
Lymphoma, B-Cell
Acceleration of Apoptosis by Extracellular Basic pH in a 3D Human Skin Equivalent System.
Lymphoma, B-Cell, Marginal Zone
Resistance of Hematopoietic Progenitors to Fas-Mediated Apoptosis Is Actively Sustained by NF?B with a Characteristic Transcriptional Signature.
Macular Degeneration
1,25-Dihydroxyvitamin D decreases HTRA1 promoter activity in the rhesus monkey - A plausible explanation for the influence of vitamin D on age-related macular degeneration?
A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.
A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.
Age-Related Macular Degeneration Associated ARMS2 is not a Mitochondrial but Cytosolic Protein.
Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA.
AGE-RELATED MACULAR DEGENERATION PHENOTYPES ASSOCIATED WITH MUTUALLY EXCLUSIVE HOMOZYGOUS RISK VARIANTS IN CFH AND HTRA1 GENES.
Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration.
AMD-Associated HTRA1 Variants Do Not Influence TGF-? Signaling in Microglia.
AMD-associated silent polymorphisms in HtrA1 impair its ability to antagonize IGF-1.
An association of neovascular age-related macular degeneration with polymorphisms of CFH, ARMS2, HTRA1 and C3 genes in Czech population.
Analyses of single nucleotide polymorphisms and haplotype linkage of LOC387715 and the HTRA1 gene in exudative age-related macular degeneration in a Chinese cohort.
Analysis of complement factor H Y402H, LOC387715, HTRA1 polymorphisms and ApoE alleles with susceptibility to age-related macular degeneration in Hungarian patients.
Analysis of the chromosome 10q26 region indicates the intergenic region between the tagSNP rs3793917 and rs11200638 in the HTRA1 gene as associated with age-related macular degeneration.
ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations.
ARMS2/HTRA1 and CFH polymorphisms are not associated with choroidal neovascularization in highly myopic eyes of the elderly Japanese population.
Assessment of CFH and HTRA1 polymorphisms in age-related macular degeneration using classic and machine-learning approaches.
Association between high-risk disease loci and response to anti-vascular endothelial growth factor treatment for wet age-related macular degeneration.
Association of CFH, LOC387715, and HTRA1 polymorphisms with exudative age-related macular degeneration in a northern Chinese population.
Association of genetic polymorphisms with response to bevacizumab for neovascular age-related macular degeneration in the Chinese population.
Association of HTRA1 and CFH gene polymorphisms with age-related macular degeneration in Ningbo, China.
Association of HTRA1 polymorphism and bilaterality in advanced age-related macular degeneration.
Association of HTRA1 promoter polymorphism with spinal disc degeneration in Japanese women.
Association of HTRA1 rs11200638 with age-related macular degeneration (AMD) in Brazilian patients.
Association of Single Nucleotide Polymorphisms in CFH, ARMS2 and HTRA1 Genes with Risk of Age-related Macular Degeneration in Egyptian Patients.
Association of Single-Nucleotide Polymorphisms in Age-Related Macular Degeneration With Pseudodrusen: Secondary Analysis of Data From the Comparison of AMD Treatments Trials.
Association of specific genetic polymorphisms with age-related macular degeneration in a northern Chinese population.
Association of the HTRA1 -625G>A promoter gene polymorphism with exudative age-related macular degeneration in a Central European population.
Association of the HTRA1 gene variant with age-related macular degeneration in the Japanese population.
Biologically Active Fibronectin Fragments Stimulate Release of MCP-1 and Catabolic Cytokines from Murine Retinal Pigment Epithelium.
Bringing the age-related macular degeneration high-risk allele age-related maculopathy susceptibility 2 into focus with stem cell technology.
CFH, VEGF and HTRA1 promoter genotype may influence the response to intravitreal ranibizumab therapy for neovascular age-related macular degeneration.
CFH, VEGF, and PEDF genotypes and the response to intravitreous injection of bevacizumab for the treatment of age-related macular degeneration.
Characterization of the 10q26-orthologue in rhesus monkeys corroborates a functional connection between ARMS2 and HTRA1.
Chlamydia infection status, genotype, and age-related macular degeneration.
Chromosome 10q26 locus and age-related macular degeneration: a progress update.
Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium.
Common polymorphisms of the CFH, LOC 387715/ARMS2 and HTRA1 genes may not influence the intra-familial variability of X-linked juvenile retinoschisis.
Complement Factor H and High-Temperature Requirement A-1 Genotypes and Treatment Response of Age-related Macular Degeneration.
Correlation between CFH Y402H and HTRA1 rs11200638 genotype to typical exudative age-related macular degeneration and polypoidal choroidal vasculopathy phenotype in the Japanese population.
Development of a Genotype Assay for Age-Related Macular Degeneration: The EYE-RISK Consortium.
Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy.
FPR1 interacts with CFH, HTRA1 and smoking in exudative age-related macular degeneration and polypoidal choroidal vasculopathy.
Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration.
Gene polymorphisms associated with an increased risk of exudative age-related macular degeneration in a Spanish population.
Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration.
Genetic associations of anti-vascular endothelial growth factor therapy response in age-related macular degeneration: a systematic review and meta-analysis.
Genetic variants in three genes and smoking show strong associations with susceptibility to exudative age-related macular degeneration in a Chinese population.
Genome-wide association study of neovascular age-related macular degeneration in the Thai population.
Genotype-phenotype correlations for exudative age-related macular degeneration associated with homozygous HTRA1 and CFH genotypes.
Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age-Related Macular Degeneration.
HTRA1 (High Temperature Requirement A Serine Peptidase 1) Gene Is Transcriptionally Regulated by Insertion/Deletion Nucleotides Located at the 3' End of the ARMS2 (Age-related Maculopathy Susceptibility 2) Gene in Patients with Age-related Macular Degeneration.
HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication.
HTRA1 and TGF-?1 Concentrations in the Aqueous Humor of Patients With Neovascular Age-Related Macular Degeneration.
HTRA1 in Age-Related Macular Degeneration.
HtrA1 Is Specifically Up-Regulated in Active Keloid Lesions and Stimulates Keloid Development.
HTRA1 Overexpression Induces the Exudative Form of Age-related Macular Degeneration.
HTRA1 polymorphism in dry and wet age-related macular degeneration.
HTRA1 Promoter Polymorphism and Risk of Age-Related Macular Degeneration: A Meta-Analysis.
HTRA1 promoter polymorphism in wet age-related macular degeneration.
HTRA1 promoter polymorphism predisposes Japanese to age-related macular degeneration.
HTRA1 promoter variant differentiates polypoidal choroidal vasculopathy from exudative age-related macular degeneration.
HTRA1 variant confers similar risks to geographic atrophy and neovascular age-related macular degeneration.
HTRA1 variant increases risk to neovascular age-related macular degeneration in Chinese population.
HTRA1 variants in exudative age-related macular degeneration and interactions with smoking and CFH.
HTRA1, an age-related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1.
HtrA1: a novel regulator of physiological and pathological matrix mineralization?
Human HtrA1 in the archived eyes with age-related macular degeneration.
Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome.
Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening.
Incidence and Progression of Nongeographic Atrophy in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Clinical Trial.
Influence of CFH, HTRA1 and ARMS2 polymorphisms in the response to intravitreal ranibizumab treatment for wet age-related macular degeneration in a Spanish population.
Joint effects of polymorphisms in the HTRA1, LOC387715/ARMS2, and CFH genes on AMD in a Caucasian population.
LOC387715/HTRA1 gene polymorphisms and susceptibility to age-related macular degeneration: A HuGE review and meta-analysis.
LOC387715/HTRA1 polymorphisms, smoking and combined effects on exudative age-related macular degeneration in a Korean population.
LOC387715/HTRA1 variants in polypoidal choroidal vasculopathy and age-related macular degeneration in a Japanese population.
Meta-analysis of the association of the HTRA1 polymorphisms with the risk of age-related macular degeneration.
Multilocus analysis of age-related macular degeneration.
N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration.
Nonclinical Safety Assessment of FHTR2163, An Antigen-Binding Fragment Against HTRA1 for the Treatment of Geographic Atrophy.
Phase I Study of the Anti-HtrA1 Antibody-Binding Fragment FHTR2163 in Geographic Atrophy Secondary to Age-Related Macular Degeneration.
Polymorphism rs11200638 enhanced HtrA1 responsiveness and expression are associated with age-related macular degeneration.
Polymorphisms in CFH, HTRA1 and CX3CR1 confer risk to exudative age-related macular degeneration in Han Chinese.
Protective effects of an HTRA1 insertion-deletion variant against age-related macular degeneration in the Chinese populations.
Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease.
Reticular pseudodrusen: current understanding.
Rhesus monkeys and humans share common susceptibility genes for age-related macular disease.
Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency.
Sequence variants in HTRA1 and LOC387715/ARMS2 and phenotype and response to photodynamic therapy in neovascular age-related macular degeneration in populations from Israel.
Serum APOE, leptin, CFH and HTRA1 levels in Pakistani age related macular degeneration patients.
Significant Association Between Variant in SGCD and Age-Related Macular Degeneration.
Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1.
Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-? signaling.
The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples.
The inhibitory effect of IFN-? on protease HTRA1 expression in rheumatoid arthritis.
The presence of CFH, HTRA1, ARMS2, VEGF-A and VEGF-R and the appearance of age-related macular degeneration sub-types.
The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody.
Two genetic pathways for age-related macular degeneration.
Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients.
Variations in five genes and the severity of age-related macular degeneration: results from the Muenster aging and retina study.
Malocclusion
Malocclusion model of temporomandibular joint osteoarthritis in mice with and without receptor for advanced glycation end products.
Melanoma
Radiation-inducible HtrA2 gene enhances radiosensitivity of uveal melanoma OCM-1 cells in vitro and in vivo.
Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer.
The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells.
Meningioma
Decrease in serine protease HtrA1 expression correlates with grade and recurrence in meningiomas.
Integration and Comparison of Transcriptomic and Proteomic Data for Meningioma.
Mesothelioma
Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma.
Electroporation as a strategy to promote HtrA1 gene uptake and chemotherapy efficacy in a mouse model of mesothelioma.
Piroxicam and cisplatin in a mouse model of peritoneal mesothelioma.
The serine protease HtrA1 is a novel prognostic factor for human mesothelioma.
Mesothelioma, Malignant
The serine protease HtrA1 is a novel prognostic factor for human mesothelioma.
Metabolic Diseases
Expression of insulin-like growth factor binding protein genes and its hypoxic regulation in U87 glioma cells depends on ERN1 mediated signaling pathway of endoplasmic reticulum stress.
Movement Disorders
HTRA2 Defect: A Recognizable Inborn Error of Metabolism with 3-Methylglutaconic Aciduria as Discriminating Feature Characterized by Neonatal Movement Disorder and Epilepsy-Report of 11 Patients.
Multiple Sclerosis
Associations between IL1RAP rs4624606, IL1RL1 rs1041973, IL-6 rs1800795, and HTRA1 rs11200638 gene polymorphisms and development of optic neuritis with or without multiple sclerosis.
The levels of the serine protease HTRA1 in cerebrospinal fluid correlate with progression and disability in multiple sclerosis.
Muscle Hypotonia
Pathogenic variants in HTRA2 cause an early-onset mitochondrial syndrome associated with 3-methylglutaconic aciduria.
Musculoskeletal Diseases
The Emerging Roles of HTRA1 in Musculoskeletal Disease.
Myocardial Infarction
Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury.
Circulating HtrA2 after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: A potential novel biomarker for mitochondrial induced cardiomyocyte apoptosis and ischemia-reperfusion injury.
Circulating HtrA2 as a novel biomarker for mitochondrial induced cardiomyocyte apoptosis and ischemia-reperfusion injury in ST-segment elevation myocardial infarction.
The mitochondria-targeting peptide elamipretide diminishes circulating HtrA2 in ST-segment elevation myocardial infarction.
Neoplasm Metastasis
Analysis of HtrA1 serine protease expression in human lung cancer.
Antagonism between HTRA3 and TGF?1 Contributes to Metastasis in Non-Small Cell Lung Cancer.
Divergent Roles of PAX2 in the Etiology and Progression of Ovarian Cancer.
Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells.
Elevated serine protease HtrA1 inhibits cell proliferation, reduces invasion, and induces apoptosis in esophageal squamous cell carcinoma by blocking the nuclear factor-?B signaling pathway.
HtrA1 expression associated with the occurrence and development of esophageal cancer.
HtrA1 loss is related to aggressive behavior parameters in sentinel node positive breast cancer.
HtrA1 regulates Epithelial-mesenchymal transition in hepatocellular carcinoma.
HtrA3 is negatively correlated with lymph node metastasis in invasive ductal breast cancer.
HTRA3 is reduced in ovarian cancers regardless of stage.
PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion.
The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells.
Neoplasms
A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer.
Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities.
Allosteric Regulation of Serine Protease HtrA2 through Novel Non-Canonical Substrate Binding Pocket.
Analysis of HtrA1 serine protease expression in human lung cancer.
Analysis of RPL37A, MTSS1, and HTRA1 expression as potential markers for pathologic complete response and survival.
Antagonism between HTRA3 and TGF?1 Contributes to Metastasis in Non-Small Cell Lung Cancer.
Changes in expression of human serine protease HtrA1, HtrA2 and HtrA3 genes in benign and malignant thyroid tumors.
Changes in expression of serine proteases HtrA1 and HtrA2 during estrogen-induced oxidative stress and nephrocarcinogenesis in male Syrian hamster.
Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer.
Decidual HtrA3 negatively regulates trophoblast invasion during human placentation.
Decrease in serine protease HtrA1 expression correlates with grade and recurrence in meningiomas.
Design and synthesis of new substrates of HtrA serine peptidase 2 protease.
Divergent Roles of PAX2 in the Etiology and Progression of Ovarian Cancer.
Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways.
Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells.
Downregulation of serine protease HTRA1 is associated with poor survival in breast cancer.
Dual regulatory switch confers tighter control on HtrA2 proteolytic activity.
Electroporation as a strategy to promote HtrA1 gene uptake and chemotherapy efficacy in a mouse model of mesothelioma.
Epigenetic silencing of serine protease HTRA1 drives polyploidy.
Expression and localization of serine protease Htra1 in neuroblastoma: correlation with cellular differentiation grade.
Expression of HTRA Genes and Its Association with Microsatellite Instability and Survival of Patients with Colorectal Cancer.
Expression of human HtrA1, HtrA2, HtrA3 and TGF-beta1 genes in primary endometrial cancer.
Expression of insulin-like growth factor binding protein genes and its hypoxic regulation in U87 glioma cells depends on ERN1 mediated signaling pathway of endoplasmic reticulum stress.
Expression patterns of bone morphogenetic protein antagonists in colorectal cancer desmoplastic invasion fronts.
Gene expression profile associated with response to doxorubicin-based therapy in breast cancer.
High temperature requirement A3 (HTRA3) expression predicts postoperative recurrence and survival in patients with non-small-cell lung cancer.
High-Temperature Requirement A 1 Causes Photoreceptor Cell Death in Zebrafish Disease Models.
High-temperature requirement factor A3 (Htra3): a novel serine protease and its potential role in ovarian function and ovarian cancers.
HtrA protease family as therapeutic targets.
HtrA proteins as targets in therapy of cancer and other diseases.
HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication.
HtrA1 as a promising tissue marker in cancer: a meta-analysis.
HtrA1 Downregulation Induces Cisplatin Resistance in Lung Adenocarcinoma by Promoting Cancer Stem Cell-Like Properties.
HtrA1 expression and the prognosis of high-grade serous ovarian carcinoma: a cohort study using digital analysis.
HtrA1 expression associated with the occurrence and development of esophageal cancer.
HtrA1 in human urothelial bladder cancer: A secreted protein and a potential novel biomarker.
HtrA1 is a novel antagonist controlling FGF signaling via cleavage of FGF8.
HtrA1 loss is related to aggressive behavior parameters in sentinel node positive breast cancer.
HTRA1 promotes transdifferentiation of normal fibroblasts to cancer-associated fibroblasts through activation of the NF-?B/bFGF signaling pathway in gastric cancer.
HtrA1 suppresses the growth of pancreatic cancer cells by modulating Notch-1 expression.
HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer.
HTRA1-Dependent Cell Cycle Proteomics.
HtrA1: a novel regulator of physiological and pathological matrix mineralization?
HtrA1: Its future potential as a novel biomarker for cancer.
HtrA2 enhances the apoptotic functions of p73 on bax.
HtrA2, taming the oncogenic activities of WT1.
HtrA3 is a cellular partner of cytoskeleton proteins and TCP1? chaperonin.
HTRA3 Is a Prognostic Biomarker and Associated With Immune Infiltrates in Gastric Cancer.
HtrA3 Is Downregulated in Cancer Cell Lines and Significantly Reduced in Primary Serous and Granulosa Cell Ovarian Tumors.
HtrA3 is negatively correlated with lymph node metastasis in invasive ductal breast cancer.
HtrA3 is regulated by 15-deoxy-Delta12,14-prostaglandin J2 independently of PPARgamma in clear cell renal cell carcinomas.
HtrA3 stromal expression is correlated with tumor budding in stage II colorectal cancer.
HtrA4 Protease Promotes Chemotherapeutic-Dependent Cancer Cell Death.
Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas.
Hypoxia is involved in the reduction of HtrA3 in patients with endometrial hyperplasia and cancer.
Identification of a distal allosteric ligand binding pocket in HtrA3.
Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics.
Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening.
Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis.
Inhibition of HTRA3 stimulates trophoblast invasion during human placental development.
Integration and Comparison of Transcriptomic and Proteomic Data for Meningioma.
Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins.
Intricate structural coordination and domain plasticity regulate activity of serine protease HtrA2.
Landscape of Genome-Wide DNA Methylation of Colorectal Cancer Metastasis.
Low HtrA1 expression in patients with long?standing ulcerative colitis and colorectal cancer.
Methylation induced gene silencing of HtrA3 in smoking-related lung cancer.
Negative and positive regulation of gene expression by mouse histone deacetylase 1.
OASIS/CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro.
Ovarian serous carcinomas acquire cisplatin resistance and increased invasion through downregulation of the high-temperature-required protein A2 (HtrA2), following repeated treatment with cisplatin.
Oxidative Stress-Induced Signaling Pathways Implicated in the Pathogenesis of Parkinson's Disease.
Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression.
scribble (scrib) knockdown induces tumorigenesis by modulating Drp1-Parkin mediated mitochondrial dynamics in the wing imaginal tissues of Drosophila.
Serine protease HtrA1 as an inhibitor on proliferation invasion and migration of gastric cancer.
Serine protease HtrA1 expression in human hepatocellular carcinoma.
Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity.
Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer.
Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains.
Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-? signaling.
Temperature-induced changes of HtrA2(Omi) protease activity and structure.
The expression levels and prognostic value of high temperature required A2 (HtrA2) in NSCLC.
The expression of HtrA2 and its diagnostic value in patients with hepatocellular carcinoma.
The HtrA3 protease promotes drug-induced death of lung cancer cells by cleavage of the X-linked inhibitor of apoptosis protein (XIAP).
The inhibitory effect of IFN-? on protease HTRA1 expression in rheumatoid arthritis.
Tumor slices as a model to evaluate doxorubicin in vitro treatment and expression of trios of genes PRSS11, MTSS1, CLPTM1 and PRSS11, MTSS1, SMYD2 in canine mammary gland cancer.
Tumor Suppressors-HTRA Proteases and Interleukin-12-in Pediatric Asthma and Allergic Rhinitis Patients.
Tumor vessel up-regulation of INSR revealed by single-cell expression analysis of the tyrosine kinome and phosphatome in human cancers.
[Expression levels of the IAP antagonists XAF1, Smac/DIABLO and HtrA2 in testicular germ cell tumours]
[Frequent epigenetic inactivation of XAF1 by promotor hypermethylation in human colon cancers]
Neoplasms, Germ Cell and Embryonal
[Expression levels of the IAP antagonists XAF1, Smac/DIABLO and HtrA2 in testicular germ cell tumours]
Nervous System Diseases
Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.
Neuroblastoma
Expression and localization of serine protease Htra1 in neuroblastoma: correlation with cellular differentiation grade.
Neurodegenerative Diseases
Allosteric Regulation of Serine Protease HtrA2 through Novel Non-Canonical Substrate Binding Pocket.
Design and synthesis of new substrates of HtrA serine peptidase 2 protease.
HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA.
Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice.
Pathogenic Role of Serine Protease HtrA2/Omi in Neurodegenerative Diseases.
Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.
Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-? signaling.
Temperature-induced changes of HtrA2(Omi) protease activity and structure.
Tunicamycin-induced ER stress upregulates the expression of mitochondrial HtrA2 and promotes apoptosis through the cytosolic release of HtrA2.
Neutropenia
Pathogenic variants in HTRA2 cause an early-onset mitochondrial syndrome associated with 3-methylglutaconic aciduria.
Non-ST Elevated Myocardial Infarction
Circulating HtrA2 as a novel biomarker for mitochondrial induced cardiomyocyte apoptosis and ischemia-reperfusion injury in ST-segment elevation myocardial infarction.
Optic Neuritis
Associations between IL1RAP rs4624606, IL1RL1 rs1041973, IL-6 rs1800795, and HTRA1 rs11200638 gene polymorphisms and development of optic neuritis with or without multiple sclerosis.
Osteoarthritis
Association of HTRA1 promoter polymorphism with spinal disc degeneration in Japanese women.
Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis.
High-Temperature Requirement A1 Protease as a Rate-Limiting Factor in the Development of Osteoarthritis.
HtrA1 Is Specifically Up-Regulated in Active Keloid Lesions and Stimulates Keloid Development.
HtrA1: a novel regulator of physiological and pathological matrix mineralization?
HtrA1: Its future potential as a novel biomarker for cancer.
Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening.
Induction of high temperature requirement A1, a serine protease, by TGF-beta1 in articular chondrocytes of mouse models of OA.
Inflammatory markers associated with osteoarthritis after destabilization surgery in young mice with and without Receptor for Advanced Glycation End-products (RAGE).
Molecular structure and the role of high-temperature requirement protein 1 in skeletal disorders and cancers.
Osteoarthritis-like changes in the heterozygous sedc mouse associated with the HtrA1-Ddr2-Mmp-13 degradative pathway: a new model of osteoarthritis.
The inhibitory effect of IFN-? on protease HTRA1 expression in rheumatoid arthritis.
The role of human HtrA1 in arthritic disease.
Osteochondrodysplasias
Osteoarthritis-like changes in the heterozygous sedc mouse associated with the HtrA1-Ddr2-Mmp-13 degradative pathway: a new model of osteoarthritis.
Osteoporosis
Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment.
Phenotype-Genotype Association Analysis of ACTH-Secreting Pituitary Adenoma and Its Molecular Link to Patient Osteoporosis.
Ovarian Neoplasms
A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer.
Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer.
Divergent Roles of PAX2 in the Etiology and Progression of Ovarian Cancer.
DNA methylation-regulated microRNA pathways in ovarian serous cystadenocarcinoma: A meta-analysis.
Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells.
High-temperature requirement factor A3 (Htra3): a novel serine protease and its potential role in ovarian function and ovarian cancers.
HtrA1 sensitizes ovarian cancer cells to cisplatin-induced cytotoxicity by targeting XIAP for degradation.
HTRA3 is reduced in ovarian cancers regardless of stage.
Ovarian serous carcinomas acquire cisplatin resistance and increased invasion through downregulation of the high-temperature-required protein A2 (HtrA2), following repeated treatment with cisplatin.
Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity.
Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer.
Pancreatic Neoplasms
HtrA1 suppresses the growth of pancreatic cancer cells by modulating Notch-1 expression.
Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression.
Parkinson Disease
Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease.
Generation of a human iPSC line CIBi007-A from a patient with young-onset Parkinson's disease carrying variants in PRKN and HTRA2.
HtrA2 and Parkinson's disease: think PINK?
HTRA2 p.G399S in Parkinson disease, essential tremor, and tremulous cervical dystonia.
HTRA2 variations in Taiwanese Parkinson's disease.
HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA.
Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice.
Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease.
Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2.
Mitochondrial HTRA2 Plays a Positive, Protective Role in Dictyostelium discoideum but Is Cytotoxic When Overexpressed.
Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease.
Mitochondrial Stress Signalling: HTRA2 and Parkinson's Disease.
Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2.
Mutation analysis of LRRK2, SCNA, UCHL1, HtrA2 and GIGYF2 genes in Chinese patients with autosomal dorminant Parkinson's disease.
Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.
Novel variant Pro143Ala in HTRA2 contributes to Parkinson's disease by inducing hyperphosphorylation of HTRA2 protein in mitochondria.
Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.
The HtrA2 Drosophila model of Parkinson's disease is suppressed by the pro-survival Bcl-2 Buffy.
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.
Parkinsonian Disorders
A clinical and genetic study of early-onset and familial parkinsonism in taiwan: An integrated approach combining gene dosage analysis and next-generation sequencing.
Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease.
Monogenic Parkinson's disease and parkinsonism: Clinical phenotypes and frequencies of known mutations.
New endemic familial parkinsonism in south Moravia, Czech Republic and its genetical background.
peptidase do deficiency
HtrA2 deficiency causes mitochondrial uncoupling through the F?F?-ATP synthase and consequent ATP depletion.
HtrA2 is required for inflammatory responses in BMDMs via controlling TRAF2 stability in collagen-induced arthritis.
HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA.
HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis.
Loss of HtrA1 serine protease induces synthetic modulation of aortic vascular smooth muscle cells.
Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.
Periodontal Diseases
The novel role of HtrA1 in gingivitis, chronic and aggressive periodontitis.
Placental Insufficiency
Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood.
Pneumonia
Inhibition of HtrA2 alleviates inflammatory response and cell apoptosis in lipopolysaccharide?induced acute pneumonia in rats.
Streptococcus pneumoniae serine protease HtrA, but not SFP or PrtA, is a major virulence factor in pneumonia.
Pre-Eclampsia
Abnormal development of placenta in HtrA1-deficient mice.
Alterations of maternal plasma HTRA1 level in preeclampsia complicated by IUGR.
Association between first trimester plasma htra1 level and subsequent preeclampsia: A possible early marker?
Cellular substrates and pro-apoptotic function of the human HtrA4 protease.
Changes in the Level of Serum High-Temperature Requirement A1 (HtrA1) during Pregnancy and Its Relationship to Preeclampsia.
Differential Expression of HrtA1 and ADAM12 in Placentas from Preeclamptic and Normotensive Pregnancies.
Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes.
Elevated expression of serine protease HtrA1 in preeclampsia and its role in trophoblast cell migration and invasion.
Elevated HTRA1 and HTRA4 in severe preeclampsia and their roles in trophoblast functions.
Elevated protease HtrA4 in the maternal circulation of preeclampsia may contribute to endothelial barrier disruption by cleaving key junctional protein VE-cadherin.
Expression patterns of two serine protease HtrA1 forms in human placentas complicated by preeclampsia with and without intrauterine growth restriction.
Fetal growth restriction is a host specific response to infection with an impaired spiral artery remodeling-inducing strain of Porphyromonas gingivalis.
Gene expression profiling of pre-eclamptic placentae by RNA sequencing.
Generation and characterization of mice with a conditional null allele of the HtrA4 gene.
High temperature requirement A1 in placental tissues and serum from pre-eclamptic pregnancies with or without fetal growth restriction.
High-Temperature Requirement Protein A4 (HtrA4) Suppresses the Fusogenic Activity of Syncytin-1 and Promotes Trophoblast Invasion.
HtrA3 as an early marker for preeclampsia: specific monoclonal antibodies and sensitive high-throughput assays for serum screening.
HtrA3 Isoform-Specific ELISAs for Early Detection of Preeclampsia.
HtrA4 is up-regulated during trophoblast syncytialization and BeWo cells fail to syncytialize without HtrA4.
HtrA4 may play a major role in inhibiting endothelial repair in pregnancy complication preeclampsia.
HtrA4 Protease Promotes Chemotherapeutic-Dependent Cancer Cell Death.
Human HtrA4 Expression Is Restricted to the Placenta, Is Significantly Up-Regulated in Early-Onset Preeclampsia, and High Levels of HtrA4 Cause Endothelial Dysfunction.
Identification of a distal allosteric ligand binding pocket in HtrA3.
Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth.
Placental HtrA3 Is Regulated by Oxygen Tension and Serum Levels Are Altered during Early Pregnancy in Women Destined to Develop Preeclampsia.
Second and third trimester serum levels of HtrA1 in pregnancies affected by pre-eclampsia.
Serum HtrA1 is differentially regulated between early-onset and late-onset preeclampsia.
Serum podocalyxin for early detection of preeclampsia at 11-13 weeks of gestation.
Upregulation of HtrA4 in the placentas of patients with severe pre-eclampsia.
Pregnancy Complications
High-Temperature Requirement Protein A4 (HtrA4) Suppresses the Fusogenic Activity of Syncytin-1 and Promotes Trophoblast Invasion.
HtrA4 may play a major role in inhibiting endothelial repair in pregnancy complication preeclampsia.
Pregnancy, Ectopic
Expression of Protease HtrA1 Is Increased at the Site of Ectopic Pregnancy.
Premature Birth
First trimester HtrA1 maternal plasma level and spontaneous preterm birth.
Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth.
Prostatic Neoplasms
HtrA4 Protease Promotes Chemotherapeutic-Dependent Cancer Cell Death.
Proteinuria
Serum HtrA1 is differentially regulated between early-onset and late-onset preeclampsia.
Reperfusion Injury
Circulating HtrA2 after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: A potential novel biomarker for mitochondrial induced cardiomyocyte apoptosis and ischemia-reperfusion injury.
Circulating HtrA2 as a novel biomarker for mitochondrial induced cardiomyocyte apoptosis and ischemia-reperfusion injury in ST-segment elevation myocardial infarction.
Retinal Degeneration
Late-onset retinal degeneration pathology due to mutations in CTRP5 is mediated through HTRA1.
Retinal Detachment
Interactive expressions of HtrA1 and VEGF in human vitreous humors and fetal RPE cells.
Retinal Dystrophies
HTRA1, an age-related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1.
Retinitis Pigmentosa
High-Temperature Requirement A 1 Causes Photoreceptor Cell Death in Zebrafish Disease Models.
Retinoschisis
Common polymorphisms of the CFH, LOC 387715/ARMS2 and HTRA1 genes may not influence the intra-familial variability of X-linked juvenile retinoschisis.
Sarcoma
Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma.
Sarcopenia
Cross-sectional associations among P3NP, HtrA, Hsp70, Apelin and sarcopenia in Taiwanese population.
Scrub Typhus
Development of a quantitative real-time polymerase chain reaction assay specific for Orientia tsutsugamushi.
Seizures
Pathogenic variants in HTRA2 cause an early-onset mitochondrial syndrome associated with 3-methylglutaconic aciduria.
Seminoma
[Expression levels of the IAP antagonists XAF1, Smac/DIABLO and HtrA2 in testicular germ cell tumours]
Spinocerebellar Degenerations
Monogenic Parkinson's disease and parkinsonism: Clinical phenotypes and frequencies of known mutations.
Spondylosis
Characterization of Heterozygous HTRA1 Mutations in Taiwanese Patients With Cerebral Small Vessel Disease.
Two novel HTRA1 mutations in a European CARASIL patient.
[Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL)].
ST Elevation Myocardial Infarction
Circulating HtrA2 as a novel biomarker for mitochondrial induced cardiomyocyte apoptosis and ischemia-reperfusion injury in ST-segment elevation myocardial infarction.
Extracellular HtrA2 Induces Apoptosis in Human Umbilical Vein Endothelial Cells.
The mitochondria-targeting peptide elamipretide diminishes circulating HtrA2 in ST-segment elevation myocardial infarction.
Status Epilepticus
Alterations in the expression of the anti-apoptotic factor HAX-1 upon seizures-induced hippocampal injury in the neonatal rat brain.
Stomach Diseases
Isolation of Outer Membrane Vesicles from Helicobacter pylori.
Pathogenesis of Helicobacter pylori infection.
Stomach Neoplasms
HTRA1 gene expression in gastric epithelial cells.
HTRA1 promotes transdifferentiation of normal fibroblasts to cancer-associated fibroblasts through activation of the NF-?B/bFGF signaling pathway in gastric cancer.
HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer.
HTRA3 Is a Prognostic Biomarker and Associated With Immune Infiltrates in Gastric Cancer.
Identification of inhibitor against H. pylori HtrA protease using structure-based virtual screening and molecular dynamics simulations approaches.
Serine protease HtrA1 as an inhibitor on proliferation invasion and migration of gastric cancer.
Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity.
Streptococcal Infections
Conserved DegP protease in gram-positive bacteria is essential for thermal and oxidative tolerance and full virulence in Streptococcus pyogenes.
Stroke
How common are single gene mutations as a cause for lacunar stroke? A targeted gene panel study.
Monogenic cerebral small-vessel diseases: diagnosis and therapy. Consensus recommendations of the European Academy of Neurology.
Rs2293871 regulates HTRA1 expression and affects cerebral small vessel stroke and Alzheimer's disease.
Stroke, Lacunar
Characterization of Heterozygous HTRA1 Mutations in Taiwanese Patients With Cerebral Small Vessel Disease.
Two novel HTRA1 mutations in a European CARASIL patient.
Thyroid Cancer, Papillary
Changes in expression of human serine protease HtrA1, HtrA2 and HtrA3 genes in benign and malignant thyroid tumors.
Tuberculosis
ClgR regulation of chaperone and protease systems is essential for Mycobacterium tuberculosis parasitism of the macrophage.
Evaluation of Mycobacterium tuberculosis genes involved in resistance to killing by human macrophages.
Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis.
Targeting Multidrug Resistant Mycobacterium tuberculosis HtrA2 with Identical Chemical Entities of Fluoroquinolones.
The crystal structure of an essential high-temperature requirement protein HtrA1 (Rv1223) from Mycobacterium tuberculosis reveals its unique features.
The crystal structure of Mycobacterium tuberculosis high-temperature requirement A protein reveals an autoregulatory mechanism.
Tuberous Sclerosis
The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein.
Urinary Bladder Neoplasms
HtrA1 in human urothelial bladder cancer: A secreted protein and a potential novel biomarker.
OASIS/CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro.
Vascular Diseases
Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis.
Warts
The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death.