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benzyloxycarbonyl-Gly-Arg-S-benzyl + H2O
?
-
-
-
?
C4 complement component + H2O
?
-
-
-
?
complement component C2 + H2O
?
complement component C3 + H2O
?
-
-
-
?
complement component C4 + H2O
?
complement component C4 + H2O
complement component C4b
37°C
-
-
?
4,4'-dithiopyridine + H2O
?
-
-
-
?
Abz-GLQRALEI-Lys(Dnp)-NH2 + H2O
?
-
-
-
-
?
Abz-SLGRKIQI-Lys(Dnp)-NH2 + H2O
?
-
-
-
-
?
alpha-N-benzyloxycarbonyl-L-lysine thiobenzyl ester + H2O
?
-
-
-
?
C1-inhibitor P4-P1 fragment + H2O
?
-
-
-
-
?
C1-inhibitor P4-P4' fragment + H2O
?
-
-
-
-
?
complement component C2 + H2O
2 fragments of complement component C2
complement component C2 + H2O
?
complement component C2 + H2O
complement component C2a + complement component C2b
-
-
-
?
complement component C2 + H2O
complement component C2b + ?
-
-
-
-
?
complement component C2 P4-P1 fragment + H2O
?
-
-
-
-
?
complement component C2 P4-P4' fragment + H2O
?
-
-
-
-
?
complement component C3 + H2O
?
complement component C3 + H2O
complement component C3b + ?
-
-
-
-
?
complement component C3i + H2O
?
-
-
-
?
complement component C4 + H2O
2 fragments of complement C4
complement component C4 + H2O
?
complement component C4 + H2O
complement component C4-alpha + complement component C4-alpha'
-
-
-
?
complement component C4 + H2O
complement component C4b + ?
-
-
-
-
?
complement component C4 P4-P1 fragment + H2O
?
-
-
-
-
?
complement component C4 P4-P4' fragment + H2O
?
-
-
-
-
?
factor XIII + H2O
factor XIIIa + ?
-
-
-
-
?
fibrinogen + H2O
fibrin + ?
-
-
-
-
?
Ile-Ala-Arg 4-nitroanilide + H2O
?
-
-
-
?
N-acetylglycine-L-lysine methyl ester + H2O
?
-
-
-
?
N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester + H2O
?
-
-
-
-
?
N-carboxybenzoylglycine-L-arginine thiobenzyl ester + H2O
?
-
-
-
?
N-tert-butyloxycarbonyl-L-Leu-Gly-L-Arg-7-amido-4-methylcoumarin + H2O
tert-butyloxycarbonyl-L-Leu-Gly-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Nalpha-benzoyl-L-arginine ethyl ester + H2O
?
-
-
-
?
Nalpha-carbobenzoxy-L-lysine-4-nitrophenyl ester + H2O
?
-
-
-
?
p-tosyl-L-arginine methyl ester + H2O
?
-
-
-
?
Phe-Gly-Arg-7-amido-4-methylcoumarin + H2O
Phe-Gly-Arg + 7-amino-4-methylcoumarin
-
recombinant enzyme, low activity
-
-
?
Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
Phe-Ser-Arg + 7-amino-4-methylcoumarin
-
recombinant enzyme, low activity
-
-
?
prothrombin + H2O
thrombin + ?
-
-
-
-
?
additional information
?
-
complement component C2 + H2O
?
-
-
-
?
complement component C2 + H2O
?
-
the complement C3 convertase C4bC2b is generated by cleavage of complement C4 and complement C2
-
?
complement component C2 + H2O
?
37°C
the complement C3 convertase C4bC2b is generated by cleavage of complement C4 and complement C2
-
?
complement component C4 + H2O
?
-
-
-
?
complement component C4 + H2O
?
-
the complement C3 convertase C4bC2b is generated by cleavage of complement C4 and complement C2
-
?
complement component C4 + H2O
?
37°C
the complement C3 convertase C4bC2b is generated by cleavage of complement C4 and complement C2
-
?
complement component C4 + H2O
?
exclusively cleaves complement C4
-
-
?
complement component C2 + H2O
2 fragments of complement component C2
-
-
-
-
?
complement component C2 + H2O
2 fragments of complement component C2
-
-
-
?
complement component C2 + H2O
2 fragments of complement component C2
-
-
formation of the C3 convertase C4b2a
-
?
complement component C2 + H2O
2 fragments of complement component C2
-
involved in lectin pathway being part of the innate immune system providing a first line of defense against infections by activation of the complement cascade
-
-
?
complement component C2 + H2O
2 fragments of complement component C2
-
human substrate
-
-
?
complement component C2 + H2O
?
-
-
-
-
?
complement component C2 + H2O
?
-
-
-
?
complement component C2 + H2O
?
-
-
-
-
?
complement component C2 + H2O
?
-
activates complement C2
-
?
complement component C2 + H2O
?
-
SP domain alone can autoactivate and cleave C2
-
?
complement component C2 + H2O
?
formation of C3 convertase C4b2a
-
-
?
complement component C3 + H2O
?
-
-
-
?
complement component C3 + H2O
?
-
very weak substrate
-
?
complement component C4 + H2O
2 fragments of complement C4
-
-
-
-
?
complement component C4 + H2O
2 fragments of complement C4
-
-
-
?
complement component C4 + H2O
2 fragments of complement C4
-
-
formation of the C3 convertase C4b2a
-
?
complement component C4 + H2O
2 fragments of complement C4
-
-
a fragment corresponding to C4b with appearance of the alpha'-chain
-
?
complement component C4 + H2O
2 fragments of complement C4
-
involved in lectin pathway being part of the innate immune system providing a first line of defense against infections by activation of the complement cascade
-
-
?
complement component C4 + H2O
2 fragments of complement C4
-
human substrate
-
-
?
complement component C4 + H2O
2 fragments of complement C4
the complement control protein CCP module is essential for cleavage
-
-
?
complement component C4 + H2O
?
-
-
-
-
?
complement component C4 + H2O
?
-
-
-
?
complement component C4 + H2O
?
-
-
-
?
complement component C4 + H2O
?
-
-
-
?
complement component C4 + H2O
?
-
-
-
-
?
complement component C4 + H2O
?
-
SP domain is able to cleave C4, but the presence of the CCP2 domain significantly increases the efficiency
-
?
complement component C4 + H2O
?
-
activation to C4b
-
-
?
complement component C4 + H2O
?
-
determination of C4b deposition on a mannan surface
-
-
?
complement component C4 + H2O
?
formation of C3 convertase C4b2a
-
-
?
Protein + H2O
?
-
-
-
?
Protein + H2O
?
-
cleaves oligopeptides that contain either Arg or Lys at their P1 positions
-
?
additional information
?
-
-
hardly any detectable activity on complement C3
-
?
additional information
?
-
-
complement C3 is not a natural substrate
-
?
additional information
?
-
-
L-ficolin/P35 competes with mannose-binding protein for Ca2+-dependent binding to MASP-2, complex activates complement
-
?
additional information
?
-
-
smallest functional unit for complement activation consists of mannose-binding protein dimers bound to MASP-2 homodimers
-
?
additional information
?
-
-
enzyme in serum is complexed with mannan-binding lectin MBL and ficolins
-
-
?
additional information
?
-
-
enzyme is complexed with the mannose-binding protein, a recognition molecule for the complement pathway
-
-
?
additional information
?
-
-
enzyme is Mg2+-dependently associated with the mannose-binding protein, a C-type lectin binding to terminal mannose and N-acetylglucosamine moieties on surfaces of certain pathogens and activating the classical complement pathway, the enzyme is not identical with C1r or C1s
-
-
?
additional information
?
-
-
substrate specificity, fluorescent amide compounds are poor substrates, overview
-
-
?
additional information
?
-
-
binding of MBL or ficolins to the cell surface carbohydrates of microbes initiates MASP activation, autoactivation of MASP-2 is the first step in the complement cascade, overview
-
-
?
additional information
?
-
binding of MBL or ficolins to the cell surface carbohydrates of microbes initiates MASP activation, autoactivation of MASP-2 is the first step in the complement cascade, overview
-
-
?
additional information
?
-
-
MASP-2 is a central component of the MBL pathway of complement activation, MBL and MASP-2 levels in serum and plasma of healthy individuals are similar and independent of gender and age, while they are increased in colorectal cancer patients, overview
-
-
?
additional information
?
-
-
the enzyme binds to the mannan-binding lectin, MBL, the complex activates the lectin pathway of the complement system, overview
-
-
?
additional information
?
-
-
the enzyme binds to the mannan-binding lectin, the complex activates the lectin pathway of the complement system, increased activity of MBL-bound MASP-2 and MASP-2-mediated complement activation in schizophrenia, while the levels of MASP-1 and unbound MBL are similar to healthy persons' levels, overview
-
-
?
additional information
?
-
-
the enzyme binds to the mannan-binding lectin, the complex activates the lectin pathway of the complement system, MASP-2 is the major protease of the lectin pathway besides MASP-1 and the minor component MASP-3, autoactivation of MASP-2 is the first step in the complement cascade, MASP-3 might be able to downregulate MASP-2 activity, overview
-
-
?
additional information
?
-
-
the enzyme binds to the mannan-binding lectin, the complex activates the lectin pathway of the complement system, overview
-
-
?
additional information
?
-
-
the enzyme binds to the mannan-binding lectin, the complex activates the lectin pathway of the complement system, overview
-
-
?
additional information
?
-
-
the lectin pathway is one of the ways leading to the cleavage of complement factor C3, a central event in the activation of the complement system, mannan-binding lectin, MBL, promotes the activation of C3 through the combined action of MASP-1 and MASP-2 without appreciable involvement of the alternative pathway, protease MASP-1 collaborates with MASP-2 in the generation of C3 convertase, overview
-
-
?
additional information
?
-
-
the lectin pathway of complement plays a key role in the immune system by recognising pathogens through patterns of sugar moities displayed on their cell sufaces and neutralizing them in an antibody-independent reaction cascade, MASP-2 binds to the mannan-binding lectin, MBL, the complex activates the lectin pathway of the complement system, interactions analysis, overview
-
-
?
additional information
?
-
-
development and evaluation of a fluorochrome-linked immunoassay for quantitative determination of MBL, MASP-2 and C3 convertase activity in serum samples, overview
-
-
?
additional information
?
-
-
MASP-2 acts in complex with mannan-binding lectin, MBL, overview
-
-
?
additional information
?
-
-
substrate specificity of MASP-2, overview
-
-
?
additional information
?
-
-
substrate specificity, overview, no activity with gelatin, the enzyme performs proteolytic autoactivation, the N-terminal third of MASP-2, i.e. MAp19 or sMAp, comprises the CUB1 and EGF modules of MASP-2 plus an extra C-terminal EQSL tetrapeptide, which is encoded by a separate exon, MAp19 is a product of alternative splicing of the MASP-2 gene and is catalytically inactive
-
-
?
additional information
?
-
-
the enzyme performs proteolytic autoactivation, mannan-binding lectin, MBL, structure and Ca2+-dependent interaction with the enzyme, overview, MAp19 is a product of alternative splicing of the MASP-2 gene and is catalytically inactive, overview
-
-
?
additional information
?
-
-
MBL-MASP complexes, bound to mannan-agarose, generate clots when incubated with calcified plasma or purified fibrinogen and factor XIII
-
-
?
additional information
?
-
-
MASP-2 has all the activities required for lectin pathway activation, it can autoactivate and cleave both complement components C4 and C2
-
-
?
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complement component C2 + H2O
2 fragments of complement component C2
complement component C2 + H2O
?
complement component C4 + H2O
2 fragments of complement C4
complement component C4 + H2O
?
factor XIII + H2O
factor XIIIa + ?
-
-
-
-
?
fibrinogen + H2O
fibrin + ?
-
-
-
-
?
prothrombin + H2O
thrombin + ?
-
-
-
-
?
additional information
?
-
complement component C2 + H2O
2 fragments of complement component C2
-
-
-
-
?
complement component C2 + H2O
2 fragments of complement component C2
-
-
-
?
complement component C2 + H2O
2 fragments of complement component C2
-
-
formation of the C3 convertase C4b2a
-
?
complement component C2 + H2O
2 fragments of complement component C2
-
involved in lectin pathway being part of the innate immune system providing a first line of defense against infections by activation of the complement cascade
-
-
?
complement component C2 + H2O
?
-
-
-
?
complement component C2 + H2O
?
-
-
-
-
?
complement component C4 + H2O
2 fragments of complement C4
-
-
-
-
?
complement component C4 + H2O
2 fragments of complement C4
-
-
-
?
complement component C4 + H2O
2 fragments of complement C4
-
-
formation of the C3 convertase C4b2a
-
?
complement component C4 + H2O
2 fragments of complement C4
-
involved in lectin pathway being part of the innate immune system providing a first line of defense against infections by activation of the complement cascade
-
-
?
complement component C4 + H2O
?
-
-
-
?
complement component C4 + H2O
?
-
-
-
-
?
complement component C4 + H2O
?
-
activation to C4b
-
-
?
Protein + H2O
?
-
-
-
?
additional information
?
-
-
complement C3 is not a natural substrate
-
?
additional information
?
-
-
L-ficolin/P35 competes with mannose-binding protein for Ca2+-dependent binding to MASP-2, complex activates complement
-
?
additional information
?
-
-
smallest functional unit for complement activation consists of mannose-binding protein dimers bound to MASP-2 homodimers
-
?
additional information
?
-
-
enzyme in serum is complexed with mannan-binding lectin MBL and ficolins
-
-
?
additional information
?
-
-
enzyme is complexed with the mannose-binding protein, a recognition molecule for the complement pathway
-
-
?
additional information
?
-
-
enzyme is Mg2+-dependently associated with the mannose-binding protein, a C-type lectin binding to terminal mannose and N-acetylglucosamine moieties on surfaces of certain pathogens and activating the classical complement pathway, the enzyme is not identical with C1r or C1s
-
-
?
additional information
?
-
-
binding of MBL or ficolins to the cell surface carbohydrates of microbes initiates MASP activation, autoactivation of MASP-2 is the first step in the complement cascade, overview
-
-
?
additional information
?
-
binding of MBL or ficolins to the cell surface carbohydrates of microbes initiates MASP activation, autoactivation of MASP-2 is the first step in the complement cascade, overview
-
-
?
additional information
?
-
-
MASP-2 is a central component of the MBL pathway of complement activation, MBL and MASP-2 levels in serum and plasma of healthy individuals are similar and independent of gender and age, while they are increased in colorectal cancer patients, overview
-
-
?
additional information
?
-
-
the enzyme binds to the mannan-binding lectin, MBL, the complex activates the lectin pathway of the complement system, overview
-
-
?
additional information
?
-
-
the enzyme binds to the mannan-binding lectin, the complex activates the lectin pathway of the complement system, increased activity of MBL-bound MASP-2 and MASP-2-mediated complement activation in schizophrenia, while the levels of MASP-1 and unbound MBL are similar to healthy persons' levels, overview
-
-
?
additional information
?
-
-
the enzyme binds to the mannan-binding lectin, the complex activates the lectin pathway of the complement system, MASP-2 is the major protease of the lectin pathway besides MASP-1 and the minor component MASP-3, autoactivation of MASP-2 is the first step in the complement cascade, MASP-3 might be able to downregulate MASP-2 activity, overview
-
-
?
additional information
?
-
-
the enzyme binds to the mannan-binding lectin, the complex activates the lectin pathway of the complement system, overview
-
-
?
additional information
?
-
-
the enzyme binds to the mannan-binding lectin, the complex activates the lectin pathway of the complement system, overview
-
-
?
additional information
?
-
-
the lectin pathway is one of the ways leading to the cleavage of complement factor C3, a central event in the activation of the complement system, mannan-binding lectin, MBL, promotes the activation of C3 through the combined action of MASP-1 and MASP-2 without appreciable involvement of the alternative pathway, protease MASP-1 collaborates with MASP-2 in the generation of C3 convertase, overview
-
-
?
additional information
?
-
-
the lectin pathway of complement plays a key role in the immune system by recognising pathogens through patterns of sugar moities displayed on their cell sufaces and neutralizing them in an antibody-independent reaction cascade, MASP-2 binds to the mannan-binding lectin, MBL, the complex activates the lectin pathway of the complement system, interactions analysis, overview
-
-
?
additional information
?
-
-
MBL-MASP complexes, bound to mannan-agarose, generate clots when incubated with calcified plasma or purified fibrinogen and factor XIII
-
-
?
additional information
?
-
-
MASP-2 has all the activities required for lectin pathway activation, it can autoactivate and cleave both complement components C4 and C2
-
-
?
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Adenocarcinoma of Lung
Analysis of genomic and transcriptomic variations as prognostic signature for lung adenocarcinoma.
Arthritis, Rheumatoid
Association of MASP-2 Levels and MASP2 Gene Polymorphisms with Rheumatoid Arthritis in Patients and Their Relatives.
Arthritis, Rheumatoid
Association of MASP2 levels and MASP2 gene polymorphisms with systemic lupus erythematosus.
Arthritis, Rheumatoid
Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2.
Autoimmune Diseases
Bipolar and panic disorders may be associated with hereditary defects in the innate immune system.
Bacteremia
Polymorphic receptors of the innate immune system (MBL/MASP-2 and TLR2/4) and susceptibility to pneumococcal bacteremia in HIV-infected patients: a case-control study.
Bacteremia
The Role of Complement Activating Collectins and Associated Serine Proteases in Patients With Hematological Malignancies, Receiving High-Dose Chemotherapy, and Autologous Hematopoietic Stem Cell Transplantations (Auto-HSCT).
Carcinoma
Clinical significance of mannose-binding lectin-associated serine protease-2 expression in esophageal squamous cell carcinoma.
Carcinoma
Mannan-binding lectin (MBL)-associated plasma protein present in human urine inhibits calcium oxalate crystal growth.
Carcinoma, Hepatocellular
MBL2 and MASP2 gene polymorphisms in patients with hepatocellular carcinoma.
Carcinoma, Renal Cell
Mannan-binding lectin (MBL)-associated plasma protein present in human urine inhibits calcium oxalate crystal growth.
Cardiomyopathies
Identification of critical regions and candidate genes for cardiovascular malformations and cardiomyopathy associated with deletions of chromosome 1p36.
Cardiomyopathies
MASP2 haplotypes are associated with high risk of cardiomyopathy in chronic Chagas disease.
Cardiovascular Diseases
Genetic Polymorphisms in Sepsis and Cardiovascular Disease: Do Similar Risk Genes Suggest Similar Drug Targets?
Chagas Disease
Deficiency in Mannose-Binding Lectin-Associated Serine Protease-2 Does Not Increase Susceptibility to Trypanosoma cruzi Infection.
Chagas Disease
Human collectin-11 (COLEC11) and its synergic genetic interaction with MASP2 are associated with the pathophysiology of Chagas Disease.
Chagas Disease
MASP2 haplotypes are associated with high risk of cardiomyopathy in chronic Chagas disease.
Coinfection
A dual role for Mannan-binding lectin-associated serine protease 2 (MASP-2) in HIV infection.
Colorectal Neoplasms
Biological variation in circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease-2 and the influence of age, gender and physical exercise.
Colorectal Neoplasms
Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer.
Colorectal Neoplasms
Pre- and postoperative levels in serum of mannan-binding lectin associated serine protease-2 -a prognostic marker in colorectal cancer.
Colorectal Neoplasms
Serum mannan-binding lectin-associated serine protease 2 levels in colorectal cancer: relation to recurrence and mortality.
Coma
The complement lectin pathway protein MAp19 and out-of-hospital cardiac arrest: Insights from two randomized clinical trials.
Communicable Diseases
Multiple Infectious Complications in a Severely Injured Patient with Single Nucleotide Polymorphisms in Important Innate Immune Response Genes.
Coronavirus Infections
Lack of association between polymorphisms of MASP2 and susceptibility to SARS coronavirus infection.
COVID-19
Anti-complement C5 therapy with eculizumab in three cases of critical COVID-19.
Dental Caries
MBL2, MASP2, AMELX, and ENAM gene polymorphisms and dental caries in Polish children.
Diabetes Mellitus, Type 1
Incident microalbuminuria and complement factor mannan-binding lectin-associated protein 19 in people with newly diagnosed type 1 diabetes.
Diabetic Nephropathies
[Triperygium wilfordii multiglucoside ameliorates kidney damage in diabetic rats by inhibiting the expressions of MBL and MASP2].
Endometrial Neoplasms
Distinct clinical and genetic mutation characteristics in sporadic and Lynch syndrome-associated endometrial cancer in a Chinese population.
Enterocolitis
Higher cord blood levels of mannose-binding lectin-associated serine protease-2 in infants with necrotising enterocolitis.
Esophageal Squamous Cell Carcinoma
Clinical significance of mannose-binding lectin-associated serine protease-2 expression in esophageal squamous cell carcinoma.
Frontotemporal Dementia
No association of TDP-43 with sporadic frontotemporal dementia.
Gout
Association of MASP2 levels and MASP2 gene polymorphisms with systemic lupus erythematosus.
Graft vs Host Disease
Mannan-binding lectin pathway deficiencies and invasive fungal infections following allogeneic stem cell transplantation.
Hematologic Neoplasms
Prognosis in pediatric hematologic malignancies is associated with serum concentration of mannose-binding lectin-associated serine protease-2 (MASP-2).
Hepatitis
Effects of MASP2 haplotypes and MASP-2 levels in hepatitis C-infected patients.
Hepatitis C
Effects of MASP2 haplotypes and MASP-2 levels in hepatitis C-infected patients.
Hepatitis C
MASP2 gene polymorphism is associated with susceptibility to hepatitis C virus infection.
Hepatitis C, Chronic
MASP2 gene polymorphism is associated with susceptibility to hepatitis C virus infection.
HIV Infections
A dual role for Mannan-binding lectin-associated serine protease 2 (MASP-2) in HIV infection.
HIV Infections
Polymorphic receptors of the innate immune system (MBL/MASP-2 and TLR2/4) and susceptibility to pneumococcal bacteremia in HIV-infected patients: a case-control study.
Infections
Association of MASP-2 Levels and MASP2 Gene Polymorphisms with Rheumatoid Arthritis in Patients and Their Relatives.
Infections
Bipolar and panic disorders may be associated with hereditary defects in the innate immune system.
Infections
Deficiency in Mannose-Binding Lectin-Associated Serine Protease-2 Does Not Increase Susceptibility to Trypanosoma cruzi Infection.
Infections
Mannose binding lectin and mannose binding lectin-associated serine protease-2 genes polymorphisms in human T-lymphotropic virus infection.
Infections
Mannose-binding lectin and mannose-binding protein-associated serine protease 2 levels and infection in very-low-birth-weight infants.
Infections
Multiplex sequence-specific polymerase chain reaction reveals new MASP2 haplotypes associated with MASP-2 and MAp19 serum levels.
Infections
[Plasma levels of mannan-binding lectin-associated serine protease 2 in children with upper respiratory tract infection].
Ischemic Stroke
Serine proteases of the complement lectin pathway and their genetic variations in ischaemic stroke.
Leprosy
Leprosy association with low MASP-2 levels generated by MASP2 haplotypes and polymorphisms flanking MAp19 exon 5.
Liver Neoplasms
Metadata checklist: identification of CHI3L1 and MASP2 as a biomarker pair for liver cancer through integrative secretome and transcriptome analysis.
Lung Diseases
Association analysis reveals genetic variation altering bleomycin-induced pulmonary fibrosis in mice.
Lung Diseases
The mannan-binding lectin pathway and lung disease in cystic fibrosis--disfunction of mannan-binding lectin-associated serine protease 2 (MASP-2) may be a major modifier.
Lung Injury
Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab.
Lupus Erythematosus, Systemic
Association of MASP2 levels and MASP2 gene polymorphisms with systemic lupus erythematosus.
Lymphoma
The Role of Complement Activating Collectins and Associated Serine Proteases in Patients With Hematological Malignancies, Receiving High-Dose Chemotherapy, and Autologous Hematopoietic Stem Cell Transplantations (Auto-HSCT).
Lymphoma, B-Cell
Polymorphisms in pattern-recognition genes in the innate immunity system and risk of non-Hodgkin lymphoma.
Lymphoma, Follicular
Polymorphisms in pattern-recognition genes in the innate immunity system and risk of non-Hodgkin lymphoma.
Lymphoma, Large B-Cell, Diffuse
Polymorphisms in pattern-recognition genes in the innate immunity system and risk of non-Hodgkin lymphoma.
Malaria
Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria.
mannan-binding lectin-associated serine protease-2 deficiency
Low clinical penetrance of mannose-binding lectin-associated serine protease 2 deficiency.
Meningitis, Bacterial
Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis.
Meningitis, Pneumococcal
Erratum to: Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis.
Meningitis, Pneumococcal
Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis.
Neonatal Sepsis
Mannose-binding lectin and mannose-binding protein-associated serine protease 2 levels and infection in very-low-birth-weight infants.
Neoplasms
Deficiency of mannose-binding lectin-associated serine protease-2 associated with increased risk of fever and neutropenia in pediatric cancer patients.
Neoplasms
Mannose-Binding Lectin (MBL) and MBL-associated serine protease-2 (MASP-2) in women with malignant and benign ovarian tumours.
Neutropenia
Deficiency of mannose-binding lectin-associated serine protease-2 associated with increased risk of fever and neutropenia in pediatric cancer patients.
Osteoarthritis
Association of MASP2 levels and MASP2 gene polymorphisms with systemic lupus erythematosus.
Out-of-Hospital Cardiac Arrest
The complement lectin pathway protein MAp19 and out-of-hospital cardiac arrest: Insights from two randomized clinical trials.
Ovarian Neoplasms
Mannose-Binding Lectin (MBL) and MBL-associated serine protease-2 (MASP-2) in women with malignant and benign ovarian tumours.
Pancreatitis
Mannan-binding lectin and mannan-binding lectin-associated serine protease 2 in acute pancreatitis.
Pemphigus
Circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease 2 in endemic pemphigus foliaceus.
Persistent Infection
Construction of human MASP-2-CCP1/2SP, CCP2SP, SP plasmid DNA nanolipoplexes and the effects on tuberculosis in BCG-infected mice.
Pneumococcal Infections
Polymorphic receptors of the innate immune system (MBL/MASP-2 and TLR2/4) and susceptibility to pneumococcal bacteremia in HIV-infected patients: a case-control study.
Pneumococcal Infections
Serotype-specific pneumococcal disease may be influenced by MBL-deficiency.
Pneumonia
Clinical and immunogenetic factors associated with pneumonia in patients with systemic lupus erythematosus: a case-control study.
Pneumonia
Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults.
Proteinuria
The Lectin Pathway of Complement Activation in Patients with Systemic Lupus Erythematosus.
Psoriasis
Functional MASP2 single nucleotide polymorphism plays no role in psoriasis.
Reperfusion Injury
Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4.
Reperfusion Injury
Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury.
Rheumatic Diseases
Association of MASP2 levels and MASP2 gene polymorphisms with systemic lupus erythematosus.
Rheumatic Fever
Association of MASP2 polymorphisms and protein levels with rheumatic fever and rheumatic heart disease.
Rheumatic Fever
Functional MASP2 gene polymorphism in patients with history of rheumatic fever.
Rheumatic Heart Disease
Association of MASP2 polymorphisms and protein levels with rheumatic fever and rheumatic heart disease.
Schistosomiasis haematobia
Low MBL-associated serine protease 2 (MASP-2) levels correlate with urogenital schistosomiasis in Nigerian children.
Sepsis
Genetic Polymorphisms in Sepsis and Cardiovascular Disease: Do Similar Risk Genes Suggest Similar Drug Targets?
Sepsis
Mannose-binding lectin and mannose-binding protein-associated serine protease 2 levels and infection in very-low-birth-weight infants.
Sjogren's Syndrome
Association of MASP2 levels and MASP2 gene polymorphisms with systemic lupus erythematosus.
Spondylitis, Ankylosing
Association of MASP2 levels and MASP2 gene polymorphisms with systemic lupus erythematosus.
Starvation
Environmental conditions impinge on dragline silk protein composition.
Stroke
Serine proteases of the complement lectin pathway and their genetic variations in ischaemic stroke.
Thrombotic Microangiopathies
MASP2 levels are elevated in thrombotic microangiopathies: association with microvascular endothelial cell injury and suppression by anti-MASP2 antibody narsoplimab.
Tuberculosis
Construction of human MASP-2-CCP1/2SP, CCP2SP, SP plasmid DNA nanolipoplexes and the effects on tuberculosis in BCG-infected mice.
Tuberculosis
Impact of MASP2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis.
Tuberculosis, Pulmonary
Mannan-binding lectin-associated serine protease-2 (MASP-2) deficiency in two patients with pulmonary tuberculosis and one healthy control.
Virus Diseases
MASP2 gene polymorphism is associated with susceptibility to hepatitis C virus infection.
Virus Diseases
MBL2 and MASP2 gene polymorphisms in patients with hepatocellular carcinoma.
West Nile Fever
The lectin pathway of complement activation contributes to protection from West Nile virus infection.
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Stoichiometry of complexes between mannose-binding protein and its associated serine proteases. Defining functional units for complement activation
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Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2
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Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments
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Homo sapiens
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Homo sapiens
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A second serine protease associated with mannan-binding lectin that activates complement
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Homo sapiens
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Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-lik serine protease
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Homo sapiens
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Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals
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Homo sapiens
brenda
Harmat, V.; Gal, P.; Kardos, J.; Szilagyi, K.; Ambrus, G.; Vegh, B.; Naray-Szabo, G.; Zavodszky, P.
The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions
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Homo sapiens (Q92876)
brenda
Presanis, J.S.; Hajela, K.; Ambrus, G.; Gal, P.; Sim, R.B.
Differential substrate and inhibitor profiles for human MASP-1 and MASP-2
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2004
Homo sapiens
brenda
Verma, A.; Matta, A.; Shukla, N.K.; Deo, S.V.; Gupta, S.D.; Ralhan, R.
Clinical significance of mannose-binding lectin-associated serine protease-2 expression in esophageal squamous cell carcinoma
Int. J. Cancer
118
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2006
Homo sapiens (O00187), Homo sapiens
brenda
Gal, P.; Harmat, V.; Kocsis, A.; Bian, T.; Barna, L.; Ambrus, G.; Vegh, B.; Balczer, J.; Sim, R.B.; Naray-Szabo, G.; Zavodszky, P.
A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations
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280
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2005
Homo sapiens (O00187)
brenda
Rossi, V.; Teillet, F.; Thielens, N.M.; Bally, I.; Arlaud, G.J.
Functional characterization of complement proteases C1s/mannan-binding lectin-associated serine protease-2 (MASP-2) chimeras reveals the higher C4 recognition efficacy of the MASP-2 complement control protein modules
J. Biol. Chem.
280
41811-41818
2005
Homo sapiens (O00187)
brenda
Teillet, F.; Dublet, B.; Andrieu, J.P.; Gaboriaud, C.; Arlaud, G.J.; Thielens, N.M.
The Two Major Oligomeric Forms of Human Mannan-Binding Lectin: Chemical Characterization, Carbohydrate-Binding Properties, and Interaction with MBL-Associated Serine Proteases
J. Immunol.
174
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2005
Homo sapiens (O00187), Homo sapiens
brenda
Sorensen, R.; Thiel, S.; Jensenius, J.C.
Mannan-binding-lectin-associated serine proteases, characteristics and disease associations
Semin. Immunopathol.
27
299-319
2005
Homo sapiens (O00187), Rattus norvegicus (Q9JJS8)
brenda
Lozano, F.; Suarez, B.; Munoz, A.; Jensenius, J.C.; Mensa, J.; Vives, J.; Horcajada, J.P.
Novel MASP2 variants detected among North African and Sub-Saharan individuals
Tissue Antigens
66
131-135
2005
Homo sapiens (O00187), Homo sapiens
brenda
Takahashi, M.; Mori, S.; Shigeta, S.; Fujita, T.
Role of MBL-associated serine protease (MASP) on activation of the lectin complement pathway
Adv. Exp. Med. Biol.
598
93-104
2007
Homo sapiens, Homo sapiens (O00187), Mus musculus
brenda
Gal, P.; Barna, L.; Kocsis, A.; Zavodszky, P.
Serine proteases of the classical and lectin pathways: similarities and differences
Immunobiology
212
267-277
2007
Homo sapiens, Rattus norvegicus
brenda
Moller-Kristensen, M.; Thiel, S.; Sjoeholm, A.; Matsushita, M.; Jensenius, J.C.
Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway
Int. Immunol.
19
141-149
2007
Homo sapiens
brenda
Teillet, F.; Lacroix, M.; Thiel, S.; Weilguny, D.; Agger, T.; Arlaud, G.J.; Thielens, N.M.
Identification of the site of human mannan-binding lectin involved in the interaction with its partner serine proteases: the essential role of Lys55
J. Immunol.
178
5710-5716
2007
Homo sapiens
brenda
Weiss, G.; Madsen, H.O.; Garred, P.
A novel mannose-binding lectin-associated serine protease 1/3 gene variant
Scand. J. Immunol.
65
430-434
2007
Homo sapiens (O00187)
brenda
Unterberger, C.; Hanson, S.; Klingenhoff, A.; Oesterle, D.; Frankenberger, M.; Endo, Y.; Matsushita, M.; Fujita, T.; Schwaeble, W.; Weiss, E.H.; Ziegler-Heitbrock, L.; Stover, C.
Stat3 is involved in control of gene expression
Biochem. Biophys. Res. Commun.
364
1022-1025
2007
Homo sapiens, Mus musculus (Q91WP0), Mus musculus, Rattus norvegicus
brenda
Sorensen, G.L.; Petersen, I.; Thiel, S.; Fenger, M.; Christensen, K.; Kyvik, K.O.; S?rensen, T.I.; Holmskov, U.; Jensenius, J.C.
Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity
Genet. Epidemiol.
31
31-41
2007
Homo sapiens
brenda
Wallis, R.
Interactions between mannose-binding lectin and MASPs during complement activation by the lectin pathway
Immunobiology
212
289-299
2007
Homo sapiens
brenda
Walsh, M.C.; Shaffer, L.A.; Guikema, B.J.; Body, S.C.; Shernan, S.K.; Fox, A.A.; Collard, C.D.; Fung, M.; Taylor, R.P.; Stahl, G.L.
Fluorochrome-linked immunoassay for functional analysis of the mannose binding lectin complement pathway to the level of C3 cleavage
J. Immunol. Methods
323
147-159
2007
Homo sapiens
brenda
Kerr, F.K.; Thomas, A.R.; Wijeyewickrema, L.C.; Whisstock, J.C.; Boyd, S.E.; Kaiserman, D.; Matthews, A.Y.; Bird, P.I.; Thielens, N.M.; Rossi, V.; Pike, R.N.
Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor
Mol. Immunol.
45
670-677
2008
Homo sapiens
brenda
Mayilyan, K.R.; Arnold, J.N.; Presanis, J.S.; Soghoyan, A.F.; Sim, R.B.
Increased complement classical and mannan-binding lectin pathway activities in schizophrenia
Neurosci. Lett.
404
336-341
2006
Homo sapiens
brenda
Ytting, H.; Christensen, I.J.; Thiel, S.; Jensenius, J.C.; Svendsen, M.N.; Nielsen, L.; Lottenburger, T.; Nielsen, H.J.
Biological variation in circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease-2 and the influence of age, gender and physical exercise
Scand. J. Immunol.
66
458-464
2007
Homo sapiens
brenda
Schafranski, M.D.; Pereira Ferrari, L.; Scherner, D.; Torres, R.; de Messias-Reason, I.J.
Functional MASP2 gene polymorphism in patients with history of rheumatic fever
Hum. Immunol.
69
41-44
2008
Homo sapiens
brenda
Swierzko, A.S.; Cedzynski, M.; Domzalska-Popadiuk, I.; Macdonald, S.L.; Borkowska-Klos, M.; Atkinson, A.P.; Szala, A.; Jopek, A.; Jensenius, J.C.; Kawakami, M.; Szczapa, J.; Matsushita, M.; Szemraj, J.; Turner, M.L.; Kilpatrick, D.C.
Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations
Mol. Immunol.
46
1696-1701
2009
Homo sapiens
brenda
Hamad, I.; Hunter, A.C.; Szebeni, J.; Moghimi, S.M.
Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process
Mol. Immunol.
46
225-232
2008
Homo sapiens
brenda
Zehnder, A.; Fisch, U.; Hirt, A.; Niggli, F.K.; Simon, A.; Ozsahin, H.; Schlapbach, L.J.; Ammann, R.A.
Prognosis in pediatric hematologic malignancies is associated with serum concentration of mannose-binding lectin-associated serine protease-2 (MASP-2)
Pediatr. Blood Cancer
53
53-57
2009
Homo sapiens
brenda
Miller, C.; Wilgenbusch, S.; Michaels, M.; Chi, D.S.; Youngberg, G.; Krishnaswamy, G.
Molecular defects in the mannose binding lectin pathway in dermatological disease: Case report and literature review
Clin. Mol. Allergy
8
6-6
2010
Homo sapiens
brenda
Gulla, K.C.; Gupta, K.; Krarup, A.; Gal, P.; Schwaeble, W.J.; Sim, R.B.; OConnor, C.D.; Hajela, K.
Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot
Immunology
129
482-495
2010
Homo sapiens
brenda
Skjoedt, M.O.; Hummelshoj, T.; Palarasah, Y.; Honore, C.; Koch, C.; Skjodt, K.; Garred, P.
A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation
J. Biol. Chem.
285
8234-8243
2010
Homo sapiens
brenda
Thiel, S.; Kolev, M.; Degn, S.; Steffensen, R.; Hansen, A.G.; Ruseva, M.; Jensenius, J.C.
Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity
J. Immunol.
182
2939-2947
2009
Homo sapiens
brenda
Brouwer, N.; Frakking, F.N.; van de Wetering, M.D.; van Houdt, M.; Hart, M.; Budde, I.K.; Strengers, P.F.; Laursen, I.; Houen, G.; Roos, D.; Jensenius, J.C.; Caron, H.N.; Dolman, K.M.; Kuijpers, T.W.
Mannose-binding lectin (MBL) substitution: recovery of opsonic function in vivo lags behind MBL serum levels
J. Immunol.
183
3496-3504
2009
Homo sapiens
brenda
Kocsis, A.; Kekesi, K.A.; Szasz, R.; Vegh, B.M.; Balczer, J.; Dobo, J.; Zavodszky, P.; Gal, P.; Pal, G.
Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation
J. Immunol.
185
4169-4178
2010
Homo sapiens
brenda
Duncan, R.C.; Bergstroem, F.; Coetzer, T.H.; Blom, A.M.; Wijeyewickrema, L.C.; Pike, R.N.
Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4
Mol. Immunol.
49
593-600
2012
Homo sapiens
brenda
Novovic, S.; Andersen, A.M.; Ersb?ll, A.K.; Jorgensen, L.N.; Nielsen, H.J.; Jensenius, J.C.; Hansen, M.B.
Mannan-binding lectin and mannan-binding lectin-associated serine protease 2 in acute pancreatitis
Pancreas
40
1097-1102
2011
Homo sapiens
brenda
Keizer, M.P.; Pouw, R.B.; Kamp, A.M.; Patiwael, S.; Marsman, G.; Hart, M.H.; Zeerleder, S.; Kuijpers, T.W.; Wouters, D.
TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2
Eur. J. Immunol.
45
544-550
2015
Homo sapiens
brenda
Heja, D.; Harmat, V.; Fodor, K.; Wilmanns, M.; Dobo, J.; Kekesi, K.A.; Zavodszky, P.; Gal, P.; Pal, G.
Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 are essential for lectin pathway activation and reveal structural plasticity of MASP-2
J. Biol. Chem.
287
20290-20300
2012
Homo sapiens (O00187)
brenda
Degn, S.E.; Jensen, L.; Olszowski, T.; Jensenius, J.C.; Thiel, S.
Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44
J. Immunol.
191
1334-1345
2013
Homo sapiens (O00187)
brenda
Parej, K.; Hermann, A.; Donath, N.; Zavodszky, P.; Gal, P.; Dobo, J.
Dissociation and re-association studies on the interaction domains of mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, provide evidence for heterodimer formation
Mol. Immunol.
59
1-9
2014
Homo sapiens (O00187)
brenda
Jenny, L.; Ajjan, R.; King, R.; Thiel, S.; Schroeder, V.
Plasma levels of mannan-binding lectin-associated serine proteases MASP-1 and MASP-2 are elevated in type 1 diabetes and correlate with glycaemic control
Clin. Exp. Immunol.
180
227-232
2015
Homo sapiens (O00187)
brenda
Yaseen, S.; Demopulos, G.; Dudler, T.; Yabuki, M.; Wood, C.L.; Cummings, W.J.; Tjoelker, L.W.; Fujita, T.; Sacks, S.; Garred, P.; Andrew, P.; Sim, R.B.; Lachmann, P.J.; Wallis, R.; Lynch, N.; Schwaeble, W.J.
Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2
FASEB J.
31
2210-2219
2017
Homo sapiens (O00187)
brenda
Drentin, N.; Conroy, P.; Gunzburg, M.J.; Pike, R.N.; Wijeyewickrema, L.C.
Investigation of the mechanism of interaction between Mannose-binding lectin-associated serine protease-2 and complement C4
Mol. Immunol.
67
287-293
2015
Homo sapiens (O00187)
brenda
Boldt, A.B.; Beltrame, M.H.; Catarino, S.J.; Meissner, C.G.; Tizzot, R.; Messias-Reason, I.J.
A dual role for Mannan-binding lectin-associated serine protease 2 (MASP-2) in HIV infection
Mol. Immunol.
78
48-56
2016
Homo sapiens (O00187), Homo sapiens
brenda
Ojurongbe, O.; Antony, J.S.; Van Tong, H.; Meyer, C.G.; Akindele, A.A.; Sina-Agbaje, O.R.; Kremsner, P.G.; Velavan, T.P.
Low MBL-associated serine protease 2 (MASP-2) levels correlate with urogenital schistosomiasis in Nigerian children
Trop. Med. Int. Health
20
1311-1319
2015
Homo sapiens (O00187), Homo sapiens
brenda