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Information on EC 3.4.21.10 - acrosin and Organism(s) Rattus norvegicus and UniProt Accession P29293

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.10 acrosin
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This record set is specific for:
Rattus norvegicus
UNIPROT: P29293 not found.
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The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
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preferential cleavage: Arg-/-, Lys-/-
Synonyms
acrosin, sperm acrosin, beta-acrosin, alpha-acrosin, acrosomal proteinase, acrosomal protease, acrosin amidase, acrosin ii, psi-acrosin, acrosin i, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acrosin
trypsin-like serine protease of the S1 family
53 kDa fucose-binding protein
-
-
-
-
acrosin amidase
-
-
-
-
acrosomal protease
-
-
-
-
acrosomal proteinase
-
-
-
-
acrozonase
-
-
-
-
alpha-acrosin
-
-
-
-
beta-acrosin
-
-
-
-
proteinase, acrosomal
-
-
-
-
psi-acrosin
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
9068-57-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
proacrosin + H2O
acrosin + peptide
show the reaction diagram
acrosin autoactivates through an endoproteolytic cleavage at the N-terminus with subsequent conversion to the mature enzyme through C-terminus cleavages
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
proacrosin + H2O
acrosin + peptide
show the reaction diagram
acrosin autoactivates through an endoproteolytic cleavage at the N-terminus with subsequent conversion to the mature enzyme through C-terminus cleavages
-
-
?
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
precursor
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
initially present in the sperm acrosomal vesicle of mammalian spermatozoa as the zymogen form, proacrosin, converted to the active form during the acrosome reaction, after which most acrosin molecules are released from the acrosomal vesicle, with a portion remaining associated with the sperm
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ACRO_RAT
437
0
48623
Swiss-Prot
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
48623
x * 48623, calculated from the deduced amino acid sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 48623, calculated from the deduced amino acid sequence
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Raterman, D.; Springer, M.S.
The molecular evolution of acrosin in placental mammals
Mol. Reprod. Dev.
75
1196-1207
2008
Amblysomus hottentotus (B0LM06), Bos taurus (P79343), Bradypus tridactylus (B0LM16), Canis lupus familiaris, Cavia porcellus (Q60491), Cynocephalus volans (B0LM30), Diceros bicornis (B0LM26), Dugong dugon (B0LM13), Echinops telfairi (B0LM07), Elephantulus edwardii (B0LM09), Equus caballus (B0LM27), Erethizon dorsatum (B0LM36), Euphractus sexcinctus (B0LM17), Felis catus (B0LM18), Galegeeska rufescens (B0LM10), Homo sapiens (P10323), Homo sapiens, Hystrix brachyura (B0LM35), Lama glama (B0LM21), Loxodonta africana (B0LM12), Macaca mulatta, Macroscelides proboscideus (B0LM11), Manis sp. DMR-2008 (B0LM29), Mus musculus (Q3ZB05), Ochotona princeps (B0LM32), Orycteropus afer (B0LM15), Oryctolagus cuniculus (P48038), Otospermophilus beecheyi (B0LM38), Ovis aries (Q9GL10), Pan troglodytes (B0LM34), Procavia capensis (B0LM08), Puma concolor (B0LM19), Rattus fuscipes (B0LM37), Rattus norvegicus (P29293), Sorex cinereus (B0LM24), Sus scrofa (P08001), Sylvilagus floridanus (B0LM33), Tadarida brasiliensis (B0LM23), Talpa europaea (B0LM25), Tapirus pinchaque (B0LM28), Tragelaphus angasii (B0LM22), Trichechus manatus (B0LM14), Tupaia glis (B0LM31), Tursiops truncatus (B0LM20)
Manually annotated by BRENDA team