Information on EC 3.4.21.10 - acrosin

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The expected taxonomic range for this enzyme is: Euteleostomi

EC NUMBER
COMMENTARY hide
3.4.21.10
-
RECOMMENDED NAME
GeneOntology No.
acrosin
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
preferential cleavage: Arg-/-, Lys-/-
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
endopeptidase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9068-57-9
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain 1758
-
-
Manually annotated by BRENDA team
strain 1758
-
-
Manually annotated by BRENDA team
Hottentot golden mole
SwissProt
Manually annotated by BRENDA team
fragment; pale-throated three-toed sloth
SwissProt
Manually annotated by BRENDA team
goat
-
-
Manually annotated by BRENDA team
japanese quail
-
-
Manually annotated by BRENDA team
fragment; Philippine flying lemur
SwissProt
Manually annotated by BRENDA team
black rhinoceros
SwissProt
Manually annotated by BRENDA team
fragment
SwissProt
Manually annotated by BRENDA team
lesser hedgehog tenrec
SwissProt
Manually annotated by BRENDA team
fragement; Cape long-eared elephant shrew
SwissProt
Manually annotated by BRENDA team
fragment; East African long-eared elephant shrew
SwissProt
Manually annotated by BRENDA team
fragment; horse
SwissProt
Manually annotated by BRENDA team
fragment; North American porcupine
SwissProt
Manually annotated by BRENDA team
fragment; six-banded armadillo
SwissProt
Manually annotated by BRENDA team
fragment; cat
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
fragment; Malayan porcupine
SwissProt
Manually annotated by BRENDA team
fragment
SwissProt
Manually annotated by BRENDA team
fragment; African elephant
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
fragment; short-eared elephant shrew
SwissProt
Manually annotated by BRENDA team
fragment
SwissProt
Manually annotated by BRENDA team
fragment; Southern American pika
SwissProt
Manually annotated by BRENDA team
fragment; Aardvark
SwissProt
Manually annotated by BRENDA team
fragment; Beechey ground squirrel
SwissProt
Manually annotated by BRENDA team
fragment; chimpanzee
SwissProt
Manually annotated by BRENDA team
fragment; rock dassie
SwissProt
Manually annotated by BRENDA team
fragment; mountain lion
SwissProt
Manually annotated by BRENDA team
fragment; bush rat
SwissProt
Manually annotated by BRENDA team
precursor
SwissProt
Manually annotated by BRENDA team
fragment; masked shrew
SwissProt
Manually annotated by BRENDA team
fragment; cottontail rabbit
SwissProt
Manually annotated by BRENDA team
fragment; Brazilian free-tailed bat
SwissProt
Manually annotated by BRENDA team
fragment; European mole
SwissProt
Manually annotated by BRENDA team
fragment; mountain tapir
SwissProt
Manually annotated by BRENDA team
fragment; nyala
SwissProt
Manually annotated by BRENDA team
fragment; Caribbean manatee, West Indian manatee
SwissProt
Manually annotated by BRENDA team
fragment; tree shrew
SwissProt
Manually annotated by BRENDA team
fragment; Atlantic bottle-nosed dolphin
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
-
acrosin is responsible for the serine protease activity associated with the inner acrosomal membrane
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
aminobenzoyl-Ser-Lys-Gly-Arg-Ser-Leu-Ile-Gly-Lys(dinitrophenyl)-Asp + H2O
?
show the reaction diagram
-
-
-
?
collagen I + H2O
?
show the reaction diagram
-
heat denatured
-
-
?
Collagen IV + H2O
?
show the reaction diagram
-
-
-
-
?
D-valyl-L-leucyl-L-arginine p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
Fibronectin + H2O
?
show the reaction diagram
-
-
-
-
?
N-alpha-benzoyl-DL-arginine-4-nitroanilide + H2O
N-alpha-benzoyl-DL-arginine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-alpha-benzoyl-L-arginine-4-nitroanilide + H2O
N-alpha-benzoyl-L-arginine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-benzoyl-DL-arginine-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
Nalpha-benzoyl-DL-arginine 4-nitroanilide + H2O
Nalpha-benzoyl-DL-arginine + 4-nitroaniline
show the reaction diagram
Nalpha-benzoyl-DL-arginine-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
Nalpha-benzoyl-DL-lysine p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
Nalpha-benzoyl-L-arginine + H2O
?
show the reaction diagram
-
-
-
-
?
Nalpha-benzoyl-L-arginine 4-nitroanilide + H2O
Nalpha-benzoyl-L-arginine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Nalpha-benzoyl-L-arginine 4-nitroanilide hydrochloride + H2O
?
show the reaction diagram
-
-
-
-
-
Nalpha-benzoyl-L-arginine beta-naphthylamide + H2O
?
show the reaction diagram
-
-
-
-
?
Nalpha-benzoyl-L-arginine ethyl ester + H2O
?
show the reaction diagram
Nalpha-benzoyl-L-arginine ethyl ester hydrochloride + H2O
?
show the reaction diagram
-
-
-
-
?
Nalpha-benzoyl-L-arginine p-nitroanilide + H2O
?
show the reaction diagram
Nalpha-tosyl-L-arginine methyl ester + H2O
?
show the reaction diagram
proacrosin + H2O
acrosin + ?
show the reaction diagram
proacrosin + H2O
acrosin + peptide
show the reaction diagram
proteinase-activated receptor-2 + H2O
?
show the reaction diagram
toluene-p-sufonyl-L-arginine methyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
toluene-p-sulfonyl-L-arginine methyl ester hydrochloride + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
proacrosin + H2O
acrosin + ?
show the reaction diagram
proacrosin + H2O
acrosin + peptide
show the reaction diagram
proteinase-activated receptor-2 + H2O
?
show the reaction diagram
-
the enzyme may play additional role(s) in the fertilization process via the activation of PAR-2 on oocytes
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
activates
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-(2, 4-dichlorobenzoyl)-N-methyl-1H-indazole-3-carboxamide
-
-
-
2,4-dichloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
-
-
2,6-dichloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
-
-
2-(3-(2-hydroxyethyl)ureido)-N-(2-methoxybenzyl)-1H-benzo[d]imidazole-5-sulfonamide
-
-
-
2-(3-(2-hydroxyethyl)ureido)-N-(2-methylbenzyl)-1H-benzo[d]imidazole-5-sulfonamide
-
-
-
2-(3-(3-hydroxyethyl)ureido)-N-(2-methoxybenzyl)-1H-benzo[d]imidazole-5-sulfonamide
-
-
-
2-(4-chlorophenoxy)-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]acetamide
-
-
2-bromo-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
-
-
2-chloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
-
-
2-mercaptoethanol
-
-
3,4-dichloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
-
-
3-(2,4-dichlorophenyl)isoxazole-5-carbaldehyde
-
50% inhibition at 5.8 mM, weak antifungal activity against Candida albicans
3-(2-bromophenyl)isoxazole-5-carbaldehyde
-
50% inhibition at 1.25 mM, weak antifungal activity against Candida albicans
3-(2-chlorophenyl)isoxazole-5-carbaldehyde
-
50% inhibition at 1.1 mM, weak antifungal activity against Candida albicans
3-(3-bromophenyl)isoxazole-5-carbaldehyde
-
50% inhibition at 4.8 mM, weak antifungal activity against Candida albicans
3-(3-chlorophenyl)isoxazole-5-carbaldehyde
-
50% inhibition at 0.625 mM, weak antifungal activity against Candida albicans
3-(4-chlorophenyl)isoxazole-5-carbaldehyde
-
50% inhibition at 1.8 mM, weak antifungal activity against Candida albicans
3-(4-fluorophenyl)isoxazole-5-carbaldehyde
-
50% inhibition at 4.0 mM, weak antifungal activity against Candida albicans
3-(4-nitrophenyl)-1,2-oxazole-5-carbaldehyde
-
-
3-(4-nitrophenyl)isoxazole-5-carbaldehyde
-
50% inhibition at 0.42 mM, weak antifungal activity against Candida albicans
3-chloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
-
-
3-methylbutyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
-
-
3-[4-([[4-(aminomethyl)cyclohexyl]carbonyl]oxy)phenyl]propanoic acid
-
-
4-(4'-aminophenoxypropoxy)benzamidine
-
-
-
4-(4'-nitrophenyl)guanidinobenzoate
-
-
-
4-(acetylamino)phenyl 4-carbamimidamidobenzoate
-
-
4-(chloromethyl)-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
-
-
4-([4-[3-(ethoxycarbonyl)-1H-pyrazol-5-yl]phenyl]amino)-4-oxobutanoic acid
-
-
4-aminobenzamidine
-
-
4-carbomethoxyphenyl 4-guanidinobenzoate mesylate
-
4'-CMGB, a sperm acrosin inhibitor and candidate for an vaginal contraceptive drug. Method development and evaluation of 4'-CMGB identification and activity determination involving HPLC and LC-tandem mass spectrometry, overview
4-nitrophenyl-4'-guanidine benzoate
-
-
-
4-[(2-methylbenzyl)(methylsulfonyl)amino]-N-(pyridin-4-ylmethyl)benzamide
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5-(2,4-dichlorophenyl)-1,2-oxazole-3-carbaldehyde
-
-
5-(2,4-dichlorophenyl)isoxazole-3-carbaldehyde
-
50% inhibition at 0.39 mM, weak antifungal activity against Candida albicans
5-(2-chlorophenyl)isoxazole-3-carbaldehyde
-
50% inhibition at 1.0 mM, weak antifungal activity against Candida albicans
5-(3-bromophenyl)isoxazole-3-carbaldehyde
-
50% inhibition at 1.1 mM, weak antifungal activity against Candida albicans
5-(4-carbamimidamidophenyl)-N-(1-hydroxypropan-2-yl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(2,3-dimethylphenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(2,4-dimethoxyphenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(2,5-dimethoxyphenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(2,6-dimethylphenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(2-methoxyphenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(2-methylphenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(3,5-dimethylphenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(3-chlorophenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(3-methoxyphenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(3-methylphenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(4-chlorophenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(4-cyanophenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(4-ethoxyphenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(4-fluorophenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(4-methylphenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(4-methylpyridin-2-yl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(naphthalen-1-yl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-(propan-2-yl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-phenyl-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-carbamimidamidophenyl)-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
5-(4-methylphenyl)isoxazole-3-carbaldehyde
-
50% inhibition at 2.4 mM, weak antifungal activity against Candida albicans
5-([4-[3-(ethoxycarbonyl)-1H-pyrazol-5-yl]phenyl]amino)-5-oxopentanoic acid
-
-
5-Aminovaleric acid
-
-
5-phenylisoxazole-3-carbaldehyde
-
50% inhibition at 2.4 mM, weak antifungal activity against Candida albicans
6-Aminocaproic acid
-
-
7-amino-1-chloro-3-L-tosylamidoheptan-2-one
-
weak
Alpha1-antitrypsin
-
-
-
antipain
-
-
antithrombin
Aprotinin
benzamidine
Benzamidine hydrochloride
-
50% inhibition at 2.2 mM, weak antifungal activity against Candida albicans
butan-1-ol
-
-
butyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
-
-
Ca2+
-
-
D-arabinose
-
-
D-fructose
-
-
dacarbazine
-
BIC
diaminomethylene-benzenesulfonamide
-
-
-
diisopropylfluorophosphate
dithiothreitol
-
-
ethyl 1-(2, 4-dichlorobenzoyl)-1H-indazole-3-carboxylate
-
-
-
ethyl 1-(phenylcarbonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
-
ethyl 1-(thiophen-2-ylcarbonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
-
ethyl 1-[(2,4-dichlorophenyl)acetyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
-
ethyl 1-[(2,4-dichlorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
-
ethyl 1-[(2,4-dimethoxyphenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
-
ethyl 1-[(2,6-dichlorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
-
ethyl 1-[(2-bromo-4-fluorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
-
ethyl 1-[(2-chloro-4-fluorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
most potent inhibitor
ethyl 1-[(2-chlorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
-
ethyl 1-[(2-fluorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
-
ethyl 1-[(2-methoxyphenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
-
ethyl 1-[(2-methylphenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
-
ethyl 1-[(3,4-dichlorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
-
ethyl 1-[(3-fluorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
-
-
ethyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
-
-
ethyl 4-([[5-(4-carbamimidamidophenyl)-1,2-oxazol-3-yl]carbonyl]amino)benzoate hydrochloride
-
-
-
ethyl 5-(4-[[(2,4-dichlorophenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
-
-
ethyl 5-(4-[[(2,6-dichlorophenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
-
-
ethyl 5-(4-[[(2,6-difluorophenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
-
-
ethyl 5-(4-[[(2-bromophenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
-
-
ethyl 5-(4-[[(2-chlorophenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
-
-
ethyl 5-(4-[[(4-chlorophenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
-
-
ethyl 5-(4-[[(4-fluorophenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
-
-
ethyl 5-(4-[[(4-methoxyphenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
-
-
ethyl 5-(4-[[(4-methylphenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
-
-
ethyl 5-(4-[[4-(1-phenylpropyl)benzoyl]amino]phenyl)-1H-pyrazole-3-carboxylate
-
-
ethyl 5-[4-(acetylamino)phenyl]-1H-pyrazole-3-carboxylate
-
-
ethyl 5-[4-(benzoylamino)phenyl]-1,2-oxazole-3-carboxylate
-
-
ethyl 5-[4-(butanoylamino)phenyl]-1H-pyrazole-3-carboxylate
-
-
ethyl 5-[4-(pentanoylamino)phenyl]-1H-pyrazole-3-carboxylate
-
-
ethyl 5-[4-(propanoylamino)phenyl]-1H-pyrazole-3-carboxylate
-
-
ethyl 5-[4-([4-[(4-methylphenyl)sulfonyl]benzoyl]amino)phenyl]-1H-pyrazole-3-carboxylate
-
-
ethyl 5-[4-([[4-(chloromethyl)phenyl]carbonyl]amino)phenyl]-1H-pyrazole-3-carboxylate
-
-
ethyl 5-[4-[(2-chlorobenzoyl)amino]phenyl]-1,2-oxazole-3-carboxylate
-
-
ethyl 5-[4-[(3,4-dichlorobenzoyl)amino]phenyl]-1,2-oxazole-3-carboxylate
-
-
ethyl 5-[4-[(3-chloropropanoyl)amino]phenyl]-1H-pyrazole-3-carboxylate
-
-
ethyl 5-[4-[(4-benzylbenzoyl)amino]phenyl]-1H-pyrazole-3-carboxylate
-
-
ethyl 5-[4-[(4-chlorobenzoyl)amino]phenyl]1,2-oxazole-3-carboxylate
-
-
ethyl 5-[4-[(4-fluorobenzoyl)amino]phenyl]-1,2-oxazole-3-carboxylate
-
-
ethyl 5-[4-[(phenylcarbonyl)amino]phenyl]-1H-pyrazole-3-carboxylate
-
-
ethyl 5-[4-[(trifluoroacetyl)amino]phenyl]-1H-pyrazole-3-carboxylate
-
-
guanidinobenzoate
-
KF950
human protein C inhibitor
-
-
-
iodoacetate
Kazal seminal plasma inhibitor
-
-
L-1-chloro-3-[4-tosylamido]-7-amino-2-heptanone
-
-
L-arginine
-
esterolytic activity
L-histidine
-
weak
L-homoarginine
-
-
Leupeptin
methyl (6-[[4-(trifluoromethyl)phenyl]sulfamoyl]-1H-benzimidazol-2-yl)carbamate
-
-
methyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
-
-
methyl 4-methyl-3-([4-[(2-methylbenzyl)(methylsulfonyl)amino]benzoyl]amino)benzoate
-
-
methyl [6-(butylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-(hexylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-(phenylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-(propan-2-ylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(2,4-dichlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(2,4-difluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(2,5-dimethylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(2-chlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(2-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(2-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(3,4-dichlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(3,4-difluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(3,4-dimethoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(3-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(3-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(3-methylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(4-bromophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(4-chlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(4-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(4-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[(4-methylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[benzyl(methyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
methyl [6-[bis(3-methylbutyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
-
N,N-bis(2-hydroxyethyl)-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide
-
-
-
N,N-dibenzyl-2-[4-(propan-2-ylsulfamoyl)phenoxy]acetamide
-
-
N-(2-bromophenyl)-5-(4-carbamimidamidophenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
N-(2-chlorobenzyl)-2-(3-(2-hydroxyethyl)ureido)-1H-benzo[d]imidazole-5-sulfonamide
-
-
-
N-(2-fluorobenzyl)-2-(3-(2-hydroxyethyl)ureido)-1H-benzo[d]imidazole-5-sulfonamide
-
-
-
N-(2-hydroxyethyl)-5-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-carboxamide
-
-
-
N-(2-hydroxypropyl)-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide
-
-
-
N-(3, 5-difluorobenzyl)-2-(3-(2-hydroxyethyl)ureido)-1H-benzo[d]imidazole-5-sulfonamide
-
-
-
N-(3,5-dichlorobenzyl)-2-(3-(2-hydroxyethyl)ureido)-1H-benzo[d]imidazole-5-sulfonamide
-
-
-
N-(3-bromophenyl)-5-(4-carbamimidamidophenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
N-(3-hydroxypropyl)-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide
-
-
-
N-(4-chlorophenyl)-N-[2-[(2E)-2-(3-methoxy-4-methylbenzylidene)hydrazinyl]-2-oxoethyl]benzenesulfonamide (non-preferred name)
-
-
N-(4-tert-butylphenyl)-5-(4-carbamimidamidophenyl)-1,2-oxazole-3-carboxamide hydrochloride
-
-
-
N-(5-bromobenzo[d]thiazol-2-yl)-2-(4-pentylpiperazin-1-yl)acetamide
-
-
-
N-(5-bromobenzo[d]thiazol-2-yl)-2-(diisopentylamino)acetamide
-
-
-
N-(5-bromobenzo[d]thiazol-2-yl)-2-(dipentylamino)acetamide
-
-
-
N-(6-bromobenzo[d]thiazol-2-yl)-2-(dibutylamino) acetamide
-
-
-
N-alpha-tosyl-L-lysyl-chloromethyl-ketone
-
-
N-alpha-tosyl-L-lysyl-chloromethylketone
-
-
N-benzyl-2-(3-(2-hydroxyethyl)ureido)-1H-benzo[d]imidazole-5-sulfonamide
-
-
-
N-cyclohexyl-2-[(4,6-diphenylpyrimidin-2-yl)sulfanyl]acetamide
-
-
N-hexyl-2-(3-(2-hydroxyethyl)ureido)-1H-benzo[d]imidazole-5-sulfonamide
-
-
-
N-tosyl-L-lysine chloromethylketone
-
-
N-[4-(dipropylsulfamoyl)phenyl]-3,4-diethoxybenzamide
-
-
N-[4-[(4-benzylpiperazin-1-yl)carbonyl]phenyl]-2,3,5,6-tetramethylbenzenesulfonamide
-
-
N-[4-[(4-benzylpiperazin-1-yl)carbonyl]phenyl]-4-tert-butylbenzenesulfonamide
-
-
N-[4-[(4-fluorophenyl)sulfamoyl]phenyl]-3,4,5-trimethoxybenzamide
-
-
N-[4-[(4-methoxyphenyl)sulfamoyl]phenyl]-2-(naphthalen-1-yloxy)acetamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2,4,6-trimethylbenzamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2,6-difluorobenzamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(2-methylphenoxy)acetamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(2-methylpiperidin-1-yl)acetamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(3-methylphenoxy)acetamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(4-methoxyphenoxy)acetamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(4-methylphenoxy)acetamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(4-methylpiperidin-1-yl)acetamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(4-nitrophenoxy)acetamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(piperidin-1-yl)acetamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-phenoxyacetamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-3,5-dinitrobenzamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-3-(trifluoromethyl)benzamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-ethoxybenzamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-ethylbenzamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-fluorobenzamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-methoxybenzamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-methylbenzamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]butanamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]pentanamide
-
-
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]propanamide
-
-
Nalpha-benzoyl-DL-arginine p-nitroanilide
-
-
Nalpha-tosyl-L-lysine chloromethyl ketone
Nalpha-tosyl-L-phenylalanyl-chloromethane
-
-
nexin 1
-
-
-
NF064
-
-
NSC651015
-
-
NSC651016
-
-
ovomucoid
p-aminobenzamidine
p-hydroxymercuribenzoate
-
-
phenylmethylsulfonyl fluoride
-
-
phenylpyrazole
-
-
-
plasminogen activator inhibitor-1
-
-
plasminogen activator inhibitor-2
-
-
-
propan-2-yl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
-
-
propyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
-
-
Proteinase inhibitors
-
-
-
quinazolinone
-
-
seminal plasma acrosin inhibitor
-
a member of the Kazal-type subfamily from the boar reproductive tract, expression and localization in the epithelium and lumen of cauda epididymidis, seminal vesicles, prostate, and Cowper's glands, overview
-
suramin
Trypsin inhibitor
Trypsin inhibitor II
-
-
-
Trypsin-plasmin inhibitor
-
bdellin B-3
-
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-methylarachidonoyl-2'-fluoro-ethylamide
-
i.e. MET-F-AEA, significantly increases at 10 nM, whereas higher MET-F-AEA levels do not induce the enzymatic activity.10 nM MET-F-AEA combined with 0.001 mM selective CB1-receptor antagonist SR141716 significantly increases the acrosin activity, while 0.001 mM CB2-receptor antagonist, SR144528 plus 10 nM MET-F-AEA and 0.001 mM capsazapine plus 10 nM METF-AEA have a similar behavior to that observed by using 10 nM MET-F-AEA alone
lysophosphatidylcholine
-
in heparin-capacitated spermatozoa, the addition of lysophosphatidylcholine produces a significant increase (about 7fold) in acrosin activity
progesterone
-
up to 2fold activation
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.022
aminobenzoyl-Ser-Lys-Gly-Arg-Ser-Leu-Ile-Gly-Lys(dinitrophenyl)-Asp
-
pH 7.4, 37C
0.65
Nalpha-benzoyl-DL-lysine p-nitroanilide
-
-
0.44
Nalpha-benzoyl-L-arginine ethyl ester
-
-
0.28
Nalpha-benzoyl-L-arginine ethyl ester hydrochloride
-
-
1.1
Nalpha-benzoyl-L-arginine p-nitroanilide
-
-
2.7
Nalpha-benzyol-L-arginine beta-naphthylamide
-
-
-
0.77
Nalpha-tosyl-L-arginine methyl ester
-
-
0.021
toluene-p-sulfonyl-L-arginine methyl ester
-
-
additional information
additional information
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
320
aminobenzoyl-Ser-Lys-Gly-Arg-Ser-Leu-Ile-Gly-Lys(dinitrophenyl)-Asp
Sus scrofa
-
pH 7.4, 37C
115 - 162
Nalpha-benzoyl-L-Arg ethyl ester
Ovis aries
-
-
49
toluene-p-sulfonyl-L-arginine methyl ester hydrochloride
Ovis aries
-
-
-
additional information
additional information
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2.28
3-(4-nitrophenyl)isoxazole-5-carbaldehyde
-
pH 8.0, 37C
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3.78
1-(2, 4-dichlorobenzoyl)-N-methyl-1H-indazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.00563
2,4-dichloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00596
2,6-dichloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
6.04
2-(3-(2-hydroxyethyl)ureido)-N-(2-methoxybenzyl)-1H-benzo[d]imidazole-5-sulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
5.45
2-(3-(2-hydroxyethyl)ureido)-N-(2-methylbenzyl)-1H-benzo[d]imidazole-5-sulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
7.32
2-(3-(3-hydroxyethyl)ureido)-N-(2-methoxybenzyl)-1H-benzo[d]imidazole-5-sulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.00935
2-(4-chlorophenoxy)-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00763
2-bromo-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0063
2-chloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0038
3,4-dichloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.42
3-(4-nitrophenyl)-1,2-oxazole-5-carbaldehyde
Homo sapiens
-
in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37C
0.007
3-chloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00251
3-methylbutyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0033
3-[4-([[4-(aminomethyl)cyclohexyl]carbonyl]oxy)phenyl]propanoic acid
Homo sapiens
-
in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37C
0.008
4-(acetylamino)phenyl 4-carbamimidamidobenzoate
Homo sapiens
-
in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37C
0.00384
4-(chloromethyl)-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00925
4-([4-[3-(ethoxycarbonyl)-1H-pyrazol-5-yl]phenyl]amino)-4-oxobutanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.3447
4-[(2-methylbenzyl)(methylsulfonyl)amino]-N-(pyridin-4-ylmethyl)benzamide
Homo sapiens
-
in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37C
0.39 - 1.7
5-(2,4-dichlorophenyl)-1,2-oxazole-3-carbaldehyde
0.1
5-(4-carbamimidamidophenyl)-N-(1-hydroxypropan-2-yl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0115
5-(4-carbamimidamidophenyl)-N-(2,3-dimethylphenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0014
5-(4-carbamimidamidophenyl)-N-(2,4-dimethoxyphenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0023
5-(4-carbamimidamidophenyl)-N-(2,5-dimethoxyphenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0057
5-(4-carbamimidamidophenyl)-N-(2,6-dimethylphenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0084
5-(4-carbamimidamidophenyl)-N-(2-methoxyphenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0144
5-(4-carbamimidamidophenyl)-N-(2-methylphenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0121
5-(4-carbamimidamidophenyl)-N-(3,5-dimethylphenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0254
5-(4-carbamimidamidophenyl)-N-(3-chlorophenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0066
5-(4-carbamimidamidophenyl)-N-(3-methoxyphenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0094
5-(4-carbamimidamidophenyl)-N-(3-methylphenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0268
5-(4-carbamimidamidophenyl)-N-(4-chlorophenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0239
5-(4-carbamimidamidophenyl)-N-(4-cyanophenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0064
5-(4-carbamimidamidophenyl)-N-(4-ethoxyphenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0205
5-(4-carbamimidamidophenyl)-N-(4-fluorophenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0101
5-(4-carbamimidamidophenyl)-N-(4-methylphenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0214
5-(4-carbamimidamidophenyl)-N-(4-methylpyridin-2-yl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0299
5-(4-carbamimidamidophenyl)-N-(naphthalen-1-yl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.1
5-(4-carbamimidamidophenyl)-N-(propan-2-yl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0246
5-(4-carbamimidamidophenyl)-N-phenyl-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0203
5-(4-carbamimidamidophenyl)-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.0174
5-([4-[3-(ethoxycarbonyl)-1H-pyrazol-5-yl]phenyl]amino)-5-oxopentanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0095
butyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
3.24
ethyl 1-(2, 4-dichlorobenzoyl)-1H-indazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
-
0.00221
ethyl 1-(phenylcarbonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.00029
ethyl 1-[(2,4-dichlorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.00174
ethyl 1-[(2-bromo-4-fluorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.00347
ethyl 1-[(2-chloro-4-fluorophenyl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.00299
ethyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0093
ethyl 4-([[5-(4-carbamimidamidophenyl)-1,2-oxazol-3-yl]carbonyl]amino)benzoate hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
0.00044
ethyl 5-(4-[[(2,4-dichlorophenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0048
ethyl 5-(4-[[(2,6-dichlorophenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.00398
ethyl 5-(4-[[(2,6-difluorophenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0024
ethyl 5-(4-[[(2-bromophenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.00011
ethyl 5-(4-[[(2-chlorophenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.00331
ethyl 5-(4-[[(4-chlorophenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0024
ethyl 5-(4-[[(4-fluorophenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0008
ethyl 5-(4-[[(4-methoxyphenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0346
ethyl 5-(4-[[(4-methylphenyl)carbonyl]amino]phenyl)-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0033
ethyl 5-(4-[[4-(1-phenylpropyl)benzoyl]amino]phenyl)-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.023
ethyl 5-[4-(acetylamino)phenyl]-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.46
ethyl 5-[4-(benzoylamino)phenyl]-1,2-oxazole-3-carboxylate
Homo sapiens
-
pH 7.8, 37.8C
0.017
ethyl 5-[4-(butanoylamino)phenyl]-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.072
ethyl 5-[4-(pentanoylamino)phenyl]-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.014
ethyl 5-[4-(propanoylamino)phenyl]-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.000032
ethyl 5-[4-([4-[(4-methylphenyl)sulfonyl]benzoyl]amino)phenyl]-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.00331
ethyl 5-[4-([[4-(chloromethyl)phenyl]carbonyl]amino)phenyl]-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.06
ethyl 5-[4-[(2-chlorobenzoyl)amino]phenyl]-1,2-oxazole-3-carboxylate
Homo sapiens
-
pH 7.8, 37.8C
0.24
ethyl 5-[4-[(3,4-dichlorobenzoyl)amino]phenyl]-1,2-oxazole-3-carboxylate
Homo sapiens
-
pH 7.8, 37.8C
0.00576
ethyl 5-[4-[(3-chloropropanoyl)amino]phenyl]-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.00047
ethyl 5-[4-[(4-benzylbenzoyl)amino]phenyl]-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.38
ethyl 5-[4-[(4-chlorobenzoyl)amino]phenyl]1,2-oxazole-3-carboxylate
Homo sapiens
-
pH 7.8, 37.8C
0.14
ethyl 5-[4-[(4-fluorobenzoyl)amino]phenyl]-1,2-oxazole-3-carboxylate
Homo sapiens
-
pH 7.8, 37.8C
0.008
ethyl 5-[4-[(phenylcarbonyl)amino]phenyl]-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0079
ethyl 5-[4-[(trifluoroacetyl)amino]phenyl]-1H-pyrazole-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.000027
KF950
Homo sapiens
-
pH and temperature not specified in the publication
10.7
methyl (6-[[4-(trifluoromethyl)phenyl]sulfamoyl]-1H-benzimidazol-2-yl)carbamate
Homo sapiens
-
pH 8.0, 22C
0.0093
methyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.1555
methyl 4-methyl-3-([4-[(2-methylbenzyl)(methylsulfonyl)amino]benzoyl]amino)benzoate
Homo sapiens
-
in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37C
1.77
methyl [6-(butylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
1.8
methyl [6-(hexylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
1.03
methyl [6-(phenylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
0.47
methyl [6-(propan-2-ylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
1.27
methyl [6-[(2,4-dichlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
1.55
methyl [6-[(2,4-difluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
8.86
methyl [6-[(2,5-dimethylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
5.75
methyl [6-[(2-chlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
0.31
methyl [6-[(2-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
8.42
methyl [6-[(2-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
4.02
methyl [6-[(3,4-dichlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
1.59
methyl [6-[(3,4-difluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
11.5
methyl [6-[(3,4-dimethoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
1.81
methyl [6-[(3-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
7.5
methyl [6-[(3-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
5.06
methyl [6-[(3-methylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
1.64
methyl [6-[(4-bromophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
7.52
methyl [6-[(4-chlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
2.4
methyl [6-[(4-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
3.29
methyl [6-[(4-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
3.18
methyl [6-[(4-methylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
1.25
methyl [6-[benzyl(methyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
0.063
methyl [6-[bis(3-methylbutyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
Homo sapiens
-
pH 8.0, 22C
5.73
N,N-bis(2-hydroxyethyl)-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.4267
N,N-dibenzyl-2-[4-(propan-2-ylsulfamoyl)phenoxy]acetamide
Homo sapiens
-
in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37C
0.0279
N-(2-bromophenyl)-5-(4-carbamimidamidophenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
1.06
N-(2-chlorobenzyl)-2-(3-(2-hydroxyethyl)ureido)-1H-benzo[d]imidazole-5-sulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.08
N-(2-fluorobenzyl)-2-(3-(2-hydroxyethyl)ureido)-1H-benzo[d]imidazole-5-sulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
6.81
N-(2-hydroxyethyl)-5-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
-
8.92
N-(2-hydroxypropyl)-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.34
N-(3, 5-difluorobenzyl)-2-(3-(2-hydroxyethyl)ureido)-1H-benzo[d]imidazole-5-sulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
2.45
N-(3,5-dichlorobenzyl)-2-(3-(2-hydroxyethyl)ureido)-1H-benzo[d]imidazole-5-sulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0144
N-(3-bromophenyl)-5-(4-carbamimidamidophenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
1.43
N-(3-hydroxypropyl)-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.014
N-(4-chlorophenyl)-N-[2-[(2E)-2-(3-methoxy-4-methylbenzylidene)hydrazinyl]-2-oxoethyl]benzenesulfonamide (non-preferred name)
Homo sapiens
-
in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37C
0.0078
N-(4-tert-butylphenyl)-5-(4-carbamimidamidophenyl)-1,2-oxazole-3-carboxamide hydrochloride
Homo sapiens
-
pH 7.8, 37.8C
-
5.08
N-(5-bromobenzo[d]thiazol-2-yl)-2-(4-pentylpiperazin-1-yl)acetamide
Homo sapiens
-
pH and temperature not specified in the publication
-
1.09
N-(5-bromobenzo[d]thiazol-2-yl)-2-(diisopentylamino)acetamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.54
N-(5-bromobenzo[d]thiazol-2-yl)-2-(dipentylamino)acetamide
Homo sapiens
-
pH and temperature not specified in the publication
-
2.78
N-(6-bromobenzo[d]thiazol-2-yl)-2-(dibutylamino) acetamide
Homo sapiens
-
pH and temperature not specified in the publication
-
142.6
N-alpha-tosyl-L-lysyl-chloromethyl-ketone
Homo sapiens
-
pH and temperature not specified in the publication
0.1426
N-alpha-tosyl-L-lysyl-chloromethylketone
0.28
N-benzyl-2-(3-(2-hydroxyethyl)ureido)-1H-benzo[d]imidazole-5-sulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.3551
N-cyclohexyl-2-[(4,6-diphenylpyrimidin-2-yl)sulfanyl]acetamide
Homo sapiens
-
in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37C
1.62
N-hexyl-2-(3-(2-hydroxyethyl)ureido)-1H-benzo[d]imidazole-5-sulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.1426
N-tosyl-L-lysine chloromethylketone
Homo sapiens
-
pH and temperature not specified in the publication
0.3018
N-[4-(dipropylsulfamoyl)phenyl]-3,4-diethoxybenzamide
Homo sapiens
-
in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37C
0.6248
N-[4-[(4-benzylpiperazin-1-yl)carbonyl]phenyl]-2,3,5,6-tetramethylbenzenesulfonamide
Homo sapiens
-
in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37C
3.057
N-[4-[(4-benzylpiperazin-1-yl)carbonyl]phenyl]-4-tert-butylbenzenesulfonamide
Homo sapiens
-
in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37C
0.2053
N-[4-[(4-fluorophenyl)sulfamoyl]phenyl]-3,4,5-trimethoxybenzamide
Homo sapiens
-
in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37C
0.6678
N-[4-[(4-methoxyphenyl)sulfamoyl]phenyl]-2-(naphthalen-1-yloxy)acetamide
Homo sapiens
-
in 55 mM HEPES and 55 mM NaCl at pH 8.0 and 37C
0.00245
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2,4,6-trimethylbenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00718
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2,6-difluorobenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0093
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(2-methylphenoxy)acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0099
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(2-methylpiperidin-1-yl)acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00892
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(3-methylphenoxy)acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00984
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(4-methoxyphenoxy)acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00898
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(4-methylphenoxy)acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00498
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(4-methylpiperidin-1-yl)acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0042
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(4-nitrophenoxy)acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00741
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(piperidin-1-yl)acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0023
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-phenoxyacetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0025
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-3,5-dinitrobenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00705
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-3-(trifluoromethyl)benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00013
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-ethoxybenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00021
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-ethylbenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00711
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-fluorobenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00221
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-methoxybenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00206
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-methylbenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00958
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]butanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00158
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]pentanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.009
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]propanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.012
NF064
Sus scrofa
-
23C
0.7
NSC651015
0.00235
propan-2-yl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.00331
propyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.1
suramin
Sus scrofa
-
23C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
12
-
-
37
-
-
49.23
-
-
92.9
-
-
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 8.5
-
-
7.7
-
-
8.5
-
-
8.7
-
-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 10.5
-
pH 6.0: about 20% of maximal activity, pH 10.5: about 25% of maximal activity
6.5 - 8.5
-
-
6.5 - 9.5
-
pH 6.5: about 50% of maximal activity, pH 9.5: about 25% of maximal activity
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
22
-
assay at room temperature
37
-
assay at
53
-
-
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25 - 65
-
about 15% of maximal activity
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.4
isoelectric focusing
7.3
mature protein, calculated from amino acid sequence
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
40000
-
gel filtration
76000
-
gel filtration