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Reference on EC 3.4.19.9 - folate gamma-glutamyl hydrolase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rao, K.N.; Noronha, J.M.
Studies on the enzymatic hydrolysis of polyglutamyl folates by chicken liver folyl poly-gamma-glutamyl carboxypeptidase. I. Intracellular localization, purification and partial characterization of the enzyme
Biochim. Biophys. Acta
481
594-607
1977
BRENDA: Gallus gallus
Textmining: Dialysis
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Rao, K.N.; Noronha, J.M.
Studies on the enzymatic hydrolysis of polyglutamyl folates by chicken liver folyl poly-gamma-glutamyl carboxypeptidase. II. Structural studies
Biochim. Biophys. Acta
481
608-616
1977
Gallus gallus
Manually annotated by BRENDA team
Elsenhans, B.; Ahmad, O.; Rosenberg, I.H.
Isolation and characterization of pteroylpolyglutamate hydrolase from rat intestinal mucosa
J. Biol. Chem.
259
6364-6368
1984
Rattus norvegicus
Manually annotated by BRENDA team
Baugh, C.M.; Stevens, J.C.; Krumdieck, C.L.
Studies on gamma-glutamyl carboxypeptidase. I. The solid phase synthesis of analogs of polyglutamates of folic acid and their effects on human liver gamma-glutamyl carboxypeptidase
Biochim. Biophys. Acta
212
116-125
1970
Homo sapiens
Manually annotated by BRENDA team
Silink, M.; Reddel, R.; Bethel, M.; Rowe, P.B.
Gamma-glutamyl hydrolase conjugase. Purification and properties of the bovine hepatic enzyme
J. Biol. Chem.
250
5982-5994
1975
Bos taurus
Manually annotated by BRENDA team
Lakshmaiah, N.; Ramasastri, B.V.
Plasma folic acid conjugase
Methods Enzymol.
66
670-678
1980
Homo sapiens
Manually annotated by BRENDA team
Reisenauer, A.M.
Folate conjugase: two separate activities in human jejunum
Science
198
196-197
1977
Homo sapiens
Manually annotated by BRENDA team
Muro, T.; Nagamori, Y.; Okada, S.; Tominaga, Y.
Some properties and action of poly(glutamic acid) hydrolase II from Micromonospora melanosporea IFO 12515
Agric. Biol. Chem.
54
1065-1067
1990
BRENDA: Micromonospora melanosporea
Textmining: Micromonospora
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Lin, S.; Rogiers, S.; Cossins, E.A.
gamma-Glutamyl hydrolase from pea cotyledons
Phytochemistry
32
1109-1117
1993
Pisum sativum
-
Manually annotated by BRENDA team
Wang, Y.; Nimec, Z.; Ryan, T.J.; Dias, J.A.; Galivan, J.
The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells
Biochim. Biophys. Acta
1164
227-235
1993
Rattus norvegicus
Manually annotated by BRENDA team
Tanaka, T.; Hiruta, O.; Futamura, T.; Uotani, K.; Satoh, A.; Taniguchi, M.; Or, S.
Purification and characterization of poly(g-glutamic acid) hydrolase from a filamentous fungus, Myrothecium sp. TM-4222
Biosci. Biotechnol. Biochem.
57
2148-2153
1993
Myrothecium sp., Myrothecium sp. TM-4222
-
Manually annotated by BRENDA team
Kferstein, H.; Jaenicke, L.
Gamma glutamyl carboxypeptidase from chicken pancreas
Hoppe-Seyler's Z. Physiol. Chem.
353
1153-1158
1972
Gallus gallus
Manually annotated by BRENDA team
Reisenauer, A.M.; Halsted, C.H.
Human jejunal brush border folate conjugase. Characteristics and inhibition by salicylazosulfapyridine
Biochim. Biophys. Acta
659
62-69
1981
Homo sapiens
Manually annotated by BRENDA team
Horne, D.W.; Krumdieck, C.L.; Wagner, C.
Properties of folic acid gamma-glutamyl hydrolase (conjugase) in rat bile and plasma
J. Nutr.
111
442-449
1981
BRENDA: Rattus norvegicus
Textmining: Rattus
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Hartley, D.M.; Snodgrass, S.R.; Bradshaw, P.A.
The measurement of gamma-glutamyl hydrolase (conjugase) activity in rat brain
Neurochem. Res.
13
147-151
1988
BRENDA: Rattus norvegicus
Textmining: Rattus
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Chandler, C.J.; Wang, T.T.Y.; Halsted, C.H.
Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization
J. Biol. Chem.
261
928-933
1986
Homo sapiens
Manually annotated by BRENDA team
Lavoie, A.; Tripp, E.; Hoffbrand, A.V.
Sephadex-gel filtration and heat stability of human jejunal and serum pteroylpolyglutamate hydrolase (folate conjugase). Evidence for two different forms
Biochem. Med.
13
1-6
1975
Homo sapiens
Manually annotated by BRENDA team
Wang, T.T.Y.; Chandler, C.J.; Halsted, C.H.
Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization
J. Biol. Chem.
261
13551-13555
1986
Homo sapiens
Manually annotated by BRENDA team
Krungkrai, J.; Yuthavong, Y.; Webster, H.K.
High-performance liquid chromatographic assay for pteroylpolyglutamate hydrolase
J. Chromatogr.
417
47-56
1987
Homo sapiens
Manually annotated by BRENDA team
Elsenhans, B.; Selhub, J.; Rosenberg, I.H.
Assay of folylpolyglutamate hydrolase using pteroyl-labeled substrates and selective short-term bacterial uptake for product determination
Methods Enzymol.
66
663-666
1980
Rattus norvegicus
Manually annotated by BRENDA team
Rosenberg, I.H.; Saini, P.K.
Folylpolyglutamate endopeptidase from chicken intestine: isolation with the aid of affinity chromatography
Methods Enzymol.
66
667-670
1980
Gallus gallus
Manually annotated by BRENDA team
Leichter, J.; Butterworth, C.E.Jr.; Krumdieck, C.L.
Partial purification and some properties of pteroylpolyglutamate hydrolase (conjugase) from chicken pancreas
Proc. Soc. Exp. Biol. Med.
154
98-101
1977
Gallus gallus
Manually annotated by BRENDA team
Bhandari, S.D.; Gregory, J.F.3rd.; Renuart, D.R.; Merritt, A.M.
Properties of pteroylpolyglutamate hydrolase in pancreatic juice of the pig
J. Nutr.
120
467-475
1990
Sus scrofa
Manually annotated by BRENDA team
Gregory, J.F.3rd.; Ink, S.L.; Cerda, J.J.
Comparison of pteroylpolyglutamate hydrolase (folate conjugase) from porcine and human intestinal brush border membrane
Comp. Biochem. Physiol. B
88
1135-1141
1987
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Samuels, L.L.; Goutas, L.J.; Priest, D.G.; Piper, J.R.; Sirotnak, F.M.
Hydrolytic cleavage of methotrexate gamma-polyglutamates by folylpolyglutamyl hydrolase derived from various tumors and normal tissues of the mouse
Cancer Res.
46
2230-2235
1986
Mus musculus
Manually annotated by BRENDA team
Jaegerstad, M.; Olsson, I.
Pteroylpolyglutamate hydrolase of human granulocytes. I. Partial purification and kinetic studies
Scand. J. Clin. Lab. Invest.
39
343-349
1979
Homo sapiens
Manually annotated by BRENDA team
Chave, K.J.; Auger, I.E.; Galivan, J.; Ryan, T.J.
Molecular modeling and site-directed mutagenesis define the catalytic motif in human gamma -glutamyl hydrolase
J. Biol. Chem.
275
40365-40370
2000
BRENDA: Homo sapiens
Textmining: Escherichia coli
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Galivan, J.; Ryan, T.J.; Chave, K.; Rhee, M.; Yao, R.; Yin, D.
Glutamyl hydrolase: pharmacological role and enzymatic characterization
Pharmacol. Ther.
85
207-215
2000
Homo sapiens
Manually annotated by BRENDA team
Chave, K.J.; Galivan, J.; Ryan, T.J.
Site-directed mutagenesis establishes cysteine-110 as essential for enzyme activity in human gamma-glutamyl hydrolase
Biochem. J.
343
551-555
1999
BRENDA: Homo sapiens
Textmining: Mus musculus, Rattus
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Rhee, M.S.; Lindau-Shepard, B.; Chave, K.J.; Galivan, J.; Ryan, T.J.
Characterization of human cellular gamma-glutamyl hydrolase
Mol. Pharmacol.
53
1040-1046
1998
Homo sapiens
Manually annotated by BRENDA team
Li, H.; Ryan, T.J.; Chave, K.J.; Van Roey, P.
Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substrate
J. Biol. Chem.
277
24522-24529
2002
BRENDA: Homo sapiens
Textmining: Escherichia coli
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
He, P.; Varticovski, L.; Bowman, E.D.; Fukuoka, J.; Welsh, J.A.; Miura, K.; Jen, J.; Gabrielson, E.; Brambilla, E.; Travis, W.D.; Harris, C.C.
Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray
Hum. Pathol.
35
1196-1209
2004
Homo sapiens
Manually annotated by BRENDA team
Orsomando, G.; de la Garza, R.D.; Green, B.J.; Peng, M.; Rea, P.A.; Ryan, T.J.; Gregory, J.F.; Hanson, A.D.
Plant gamma-glutamyl hydrolases and folate polyglutamates: characterization, compartmentation, and co-occurrence in vacuoles
J. Biol. Chem.
280
28877-28884
2005
BRENDA: Beta vulgaris, Pisum sativum, Arabidopsis thaliana (O65355)
Textmining: Escherichia coli, Arabidopsis, plant
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Sakamoto, E.; Tsukioka, S.; Oie, S.; Kobunai, T.; Tsujimoto, H.; Sakamoto, K.; Okayama, Y.; Sugimoto, Y.; Oka, T.; Fukushima, M.; Oka, T.
Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity
Biochem. Biophys. Res. Commun.
365
801-807
2007
Homo sapiens
Automatic Mining of ENzyme DAta
Cheng, Q.; Cheng, C.; Crews, K.R.; Ribeiro, R.C.; Pui, C.H.; Relling, M.V.; Evans, W.E.
Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells
Am. J. Hum. Genet.
79
264-274
2006
Homo sapiens
Manually annotated by BRENDA team
Scorpio, A.; Chabot, D.J.; Day, W.A.; Obrien, D.K.; Vietri, N.J.; Itoh, Y.; Mohamadzadeh, M.; Friedlander, A.M.
Poly-gamma-glutamate capsule-degrading enzyme treatment enhances phagocytosis and killing of encapsulated Bacillus anthracis
Antimicrob. Agents Chemother.
51
215-222
2007
BRENDA: Bacillus phage phiNIT1
Textmining: Bacillus anthracis, Bacillus subtilis, Homo sapiens, Bacilli, Anthrax
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Alexander, J.P.; Ryan, T.J.; Ballou, D.P.; Coward, J.K.
Gamma-glutamyl hydrolase: kinetic characterization of isopeptide hydrolysis using fluorogenic substrates
Biochemistry
47
1228-1239
2008
Rattus norvegicus
Manually annotated by BRENDA team
Eisele, L.E.; Chave, K.J.; Lehning, A.C.; Ryan, T.J.
Characterization of human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer
Biochim. Biophys. Acta
1764
1479-1486
2006
BRENDA: Homo sapiens, Rattus norvegicus (Q62867)
Textmining: Rattus, plant
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Hayashi, H.; Fujimaki, C.; Inoue, K.; Suzuki, T.; Itoh, K.
Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population
Biol. Pharm. Bull.
30
839-841
2007
Homo sapiens
Manually annotated by BRENDA team
Chunhachart, O.; Itoh, T.; Sukchotiratana, M.; Tanimoto, H.; Tahara, Y.
Characterization of gamma-glutamyl hydrolase produced by Bacillus sp. isolated from Thai Thua-nao
Biosci. Biotechnol. Biochem.
70
2779-2782
2006
BRENDA: Bacillus sp. (in: Bacteria)
Textmining: Glycine max
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Kawakami, K.; Ooyama, A.; Ruszkiewicz, A.; Jin, M.; Watanabe, G.; Moore, J.; Oka, T.; Iacopetta, B.; Minamoto, T.
Low expression of gamma-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype
Br. J. Cancer
98
1555-1561
2008
Homo sapiens (Q92820)
Manually annotated by BRENDA team
Schneider, E.; Ryan, T.J.
Gamma-glutamyl hydrolase and drug resistance
Clin. Chim. Acta
374
25-32
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Chen, L.; Eitenmiller, R.R.
Optimization of the trienzyme extraction for the microbiological assay of folate in vegetables
J. Agric. Food Chem.
55
3884-3888
2007
Gallus gallus
Manually annotated by BRENDA team
Shafizadeh, T.B.; Halsted, C.H.
gamma-Glutamyl hydrolase, not glutamate carboxypeptidase II, hydrolyzes dietary folate in rat small intestine
J. Nutr.
137
1149-1153
2007
BRENDA: Rattus norvegicus
Textmining: Rattus, Suidae, Homo sapiens
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Kao, T.T.; Chang, W.N.; Wu, H.L.; Shi, G.Y.; Fu, T.F.
Recombinant zebrafish gamma-glutamyl hydrolase exhibits properties and catalytic activities comparable with those of mammalian enzyme
Drug Metab. Dispos.
37
302-309
2009
Danio rerio (Q6NY42), Danio rerio, Danio rerio AB (Q6NY42)
Manually annotated by BRENDA team
Akhtar, T.A.; McQuinn, R.P.; Naponelli, V.; Gregory, J.F.; Giovannoni, J.J.; Hanson, A.D.
Tomato gamma-glutamylhydrolases: expression, characterization, and evidence for heterodimer formation
Plant Physiol.
148
775-785
2008
BRENDA: Solanum lycopersicum (B2Z9Y3), Solanum lycopersicum (B2Z9Y4), Solanum lycopersicum (B2Z9Y5), Solanum lycopersicum
Textmining: Escherichia coli, eudicotyledons, plant
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Castellano, I.; Merlino, A.; Rossi, M.; La Cara, F.
Biochemical and structural properties of gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: An enzyme specialized in hydrolase activity
Biochimie
92
464-474
2010
BRENDA: Geobacillus thermodenitrificans
Textmining: Escherichia coli, Geobacillus
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Pollard, C.; Nitz, M.; Baras, A.; Williams, P.; Moskaluk, C.; Theodorescu, D.
Genoproteomic mining of urothelial cancer suggests {gamma}-glutamyl hydrolase and diazepam-binding inhibitor as putative urinary markers of outcome after chemotherapy
Am. J. Pathol.
175
1824-1830
2009
Homo sapiens
Manually annotated by BRENDA team
Sadahiro, S.; Suzuki, T.; Maeda, Y.; Tanaka, A.; Ogoshi, K.; Kamijo, A.; Murayama, C.; Tsukioka, S.; Sakamoto, E.; Fukui, Y.; Oka, T.
Molecular determinants of folate levels after leucovorin administration in colorectal cancer
Cancer Chemother. Pharmacol.
65
735-742
2010
Homo sapiens (Q92820), Homo sapiens
Manually annotated by BRENDA team
Smit, E.F.; Burgers, S.A.; Biesma, B.; Smit, H.J.; Eppinga, P.; Dingemans, A.M.; Joerger, M.; Schellens, J.H.; Vincent, A.; van Zandwijk, N.; Groen, H.J.
Randomized phase II and pharmacogenetic study of pemetrexed compared with pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer
J. Clin. Oncol.
27
2038-2045
2009
Homo sapiens
Manually annotated by BRENDA team
Organista-Nava, J.; Gomez-Gomez, Y.; Saavedra-Herrera, M.V.; Rivera-Ramirez, A.B.; Teran-Porcayo, M.A.; Alarcon-Romero, L.d.e.l..C.; Illades-Aguiar, B.; Leyva-Vazquez, M.A.
Polymorphisms of the gamma-glutamyl hydrolase gene and risk of relapse to acute lymphoblastic leukemia in Mexico
Leuk. Res.
34
728-732
2010
Homo sapiens
Manually annotated by BRENDA team
Tsirulnikov, K.; Abuladze, N.; Bragin, A.; Faull, K.; Cascio, D.; Damoiseaux, R.; Schibler, M.J.; Pushkin, A.
Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal
Toxicol. Appl. Pharmacol.
263
303-314
2012
Mus musculus
Manually annotated by BRENDA team
Kim, S.E.; Cole, P.D.; Cho, R.C.; Ly, A.; Ishiguro, L.; Sohn, K.J.; Croxford, R.; Kamen, B.A.; Kim, Y.I.
gamma-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate
Br. J. Cancer
109
2175-2188
2013
Homo sapiens
Manually annotated by BRENDA team
Ramos-Parra, P.; Urrea-Lopez, R.; Diaz de la Garza, R.
Folate analysis in complex food matrices: Use of a recombinant Arabidopsis ?-glutamyl hydrolase for folate deglutamylation
Food Res. Int.
54
177-185
2013
Arabidopsis thaliana (O65355)
Manually annotated by BRENDA team
Kim, S.E.; Hinoue, T.; Kim, M.S.; Sohn, K.J.; Cho, R.C.; Cole, P.D.; Weisenberger, D.J.; Laird, P.W.; Kim, Y.I.
gamma-Glutamyl hydrolase modulation significantly influences global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells
Genes Nutr.
10
444
2015
Homo sapiens
Manually annotated by BRENDA team
Chuankhayan, P.; Kao, T.T.; Lin, C.C.; Guan, H.H.; Nakagawa, A.; Fu, T.F.; Chen, C.J.
Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase
J. Med. Chem.
56
7625-7635
2013
Danio rerio (Q6NY42)
Manually annotated by BRENDA team
Fujimoto, Z.; Kimura, K.
Crystal structure of bacteriophage phiNIT1 zinc peptidase PghP that hydrolyzes gamma-glutamyl linkage of bacterial poly-gamma-glutamate
Proteins Struct. Funct. Bioinform.
80
722-732
2012
Bacillus phage phiNIT1 (Q852V1)
Manually annotated by BRENDA team
Rawat, R.; Yu, X.H.; Sweet, M.; Shanklin, J.
Conjugated fatty acid synthesis: residues 111 and 115 influence product partitioning of Momordica charantia conjugase
J. Biol. Chem.
287
16230-16237
2012
Momordica charantia (Q9SP61), Momordica charantia, Momordica, Arabidopsis
Automatic Mining of ENzyme DAta
Qiu, X.; Reed, D.; Hong, H.; MacKenzie, S.; Covello, P.
Identification and analysis of a gene from Calendula officinalis encoding a fatty acid conjugase
Plant Physiol.
125
847-855
2001
Calendula officinalis, Saccharomyces cerevisiae
Automatic Mining of ENzyme DAta
Mietkiewska, E.; Miles, R.; Wickramarathna, A.; Sahibollah, A.F.; Greer, M.S.; Chen, G.; Weselake, R.J.
Combined transgenic expression of Punica granatum conjugase (FADX) and FAD2 desaturase in high linoleic acid Arabidopsis thaliana mutant leads to increased accumulation of punicic acid
Planta
240
575-583
2014
Arabidopsis thaliana, Punica granatum (Q84UB8), Punica granatum (Q84VT2), Punica granatum, Arabidopsis
Automatic Mining of ENzyme DAta
Lim HS;Mackey AD;Tamura T;Wong SC;Picciano MF
Measurable human milk folate is increased by treatment with alpha-amylase and protease in addition to folate conjugase.
Food chemistry
63
401-407
1998
Homo sapiens
Automatic Mining of ENzyme DAta
Hanlon, MH; Ferone, R; Weaver, K; Ray, P
Enzymatic synthesis of folate and antifolate polyglutamates with Escherichia coli folylpolyglutamate synthetase.
Anal Biochem
216
345-51
1994
Saccharomyces cerevisiae
Automatic Mining of ENzyme DAta
Tsukamoto, T; Haile, WH; McGuire, JJ; Coward, JK
Mechanism-based inhibition of human folylpolyglutamate synthetase: design, synthesis, and biochemical characterization of a phosphapeptide mimic of the tetrahedral intermediate.
Arch Biochem Biophys
355
109-18
1998
Homo sapiens
Automatic Mining of ENzyme DAta
Maezawa, Y; Sakamaki, K; Oue, N; Kimura, Y; Hashimoto, I; Hara, K; Kano, K; Aoyama, T; Hiroshima, Y; Yamada, T; Yamamoto, N; Ogata, T; Ito, H; Cho, H; Shiozawa, M; Yoshikawa, T; Morinaga, S; Rino, Y; Yasui, W; Masuda, M; Miyagi, Y; Oshima, T
High gamma-glutamyl hydrolase and low folylpolyglutamate synthetase expression as prognostic biomarkers in patients with locally advanced gastric cancer who were administrated postoperative adjuvant chemotherapy with S-1.
J Cancer Res Clin Oncol
146
75-86
2020
Homo sapiens
Automatic Mining of ENzyme DAta
Kurihara, I; Shibata, H; Kobayashi, S; Suda, N; Ikeda, Y; Yokota, K; Murai, A; Saito, I; Rainey, WE; Saruta, T
Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription.
J Biol Chem
280
6721-30
2005
Homo sapiens, Saccharomyces cerevisiae
Automatic Mining of ENzyme DAta
Catterall, F; McArdle, NJ; Mitchell, L; Papayanni, A; Clifford, MN; Ioannides, C
Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins.
Food Chem Toxicol
41
1141-7
2003
Camellia sinensis, Rattus
Automatic Mining of ENzyme DAta
Wang, SM; Sun, LL; Zeng, WX; Wu, WS; Zhang, GL
Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia.
Cancer Chemother Pharmacol
74
283-9
2014
Homo sapiens
Automatic Mining of ENzyme DAta
Nishikori, K; Kubo, T; Morioka, M
Morph-dependent expression and subcellular localization of host serine carboxypeptidase in bacteriocytes of the pea aphid associated with degradation of the endosymbiotic bacterium buchnera.
Zoolog Sci
26
415-20
2009
Buchnera
Automatic Mining of ENzyme DAta
Tamura, T; Shin, YS; Buehring, KU; Stokstad, EL
The availability of folates in man: effect of orange juice supplement on intestinal conjugase.
Br J Haematol
32
123-33
1976
Homo sapiens
Automatic Mining of ENzyme DAta
Krumdieck, CL; Boots, LR; Cornwell, PE; Butterworth, CE
Estrogen stimulation of conjugase activity in the uterus of ovariectomized rats.
Am J Clin Nutr
28
530-4
1975
Rattus, Metazoa
Automatic Mining of ENzyme DAta
Kang, XL; Yadao, F; Gietz, RD; Kunz, BA
Elimination of the yeast RAD6 ubiquitin conjugase enhances base-pair transitions and G.C----T.A transversions as well as transposition of the Ty element: implications for the control of spontaneous mutation.
Genetics
130
285-94
1992
Saccharomyces cerevisiae
Automatic Mining of ENzyme DAta
Kesavan, V; Noronha, JM
Evidence for the induction and release of pancreatic folylpolyglutamate hydrolase by the ingestion of folyl polyglutamates in the rat.
Experientia
48
869-71
1992
Metazoa, Rattus
Automatic Mining of ENzyme DAta
Sikora, E; Kaminska, B; Grzelakowska-Sztabert, B
Proliferation-dependency of gamma-glutamyl hydrolase activity in various mouse cells.
Cell Biol Int Rep
16
369-75
1992
Mus musculus, Mus sp.
Automatic Mining of ENzyme DAta
Canton, MC; Cremin, FM
The effect of dietary zinc depletion and repletion on rats: Zn concentration in various tissues and activity of pancreatic gamma-glutamyl hydrolase (EC 3.4.22.12) as indices of Zn status.
Br J Nutr
64
201-9
1990
Rattus, Rattus norvegicus, Indicator
Automatic Mining of ENzyme DAta
Canton, MC; Cotter, BM; Cremin, FM; Morrissey, PA
The effect of dietary zinc deficiency on pancreatic gamma-glutamyl hydrolase (EC 3.4.22.12) activity and on the absorption of pteroylpolyglutamate in rats.
Br J Nutr
62
185-93
1989
Rattus, Homo sapiens, Rattus norvegicus
Automatic Mining of ENzyme DAta
Baggott, JE; Heimburger, DC; Krumdieck, CL; Butterworth, CE
Folate conjugase activity in the plasma and tumors of breast-cancer patients.
Am J Clin Nutr
46
295-301
1987
Homo sapiens
Automatic Mining of ENzyme DAta
Wang, TT; Reisenauer, AM; Halsted, CH
Comparison of folate conjugase activities in human, pig, rat and monkey intestine.
J Nutr
115
814-9
1985
Platyrrhini, Homo sapiens, Sus scrofa, Rattus, animal, Rodentia
Automatic Mining of ENzyme DAta
Reisenauer, AM; Halsted, CH; Jacobs, LR; Wolfe, BM
Human intestinal folate conjugase: adaptation after jejunoileal bypass.
Am J Clin Nutr
42
660-5
1985
Homo sapiens
Automatic Mining of ENzyme DAta
Honda, Y; Arakawa, T
Folic acid polyglutamate conjugase activity in liver of rats receiving diphenylhydantoin.
Tohoku J Exp Med
113
197-9
1974
Rattus
Automatic Mining of ENzyme DAta
Arnesjö, B; Erlansson, C; Jägerstad, M; Lindstrand, K
Intracellular distribution of co-lipase and folate conjugase in the rat pancreas.
Scand J Gastroenterol
8
719-24
1973
Rattus
Automatic Mining of ENzyme DAta
Santini, R; Pérez-Santiago, E; Walker, L; Butterworth, CE
Folic acid conjugase in normal human plasma and in the plasma of patients with tropical sprue.
Am J Clin Nutr
19
342-4
1966
Homo sapiens
Automatic Mining of ENzyme DAta
Salem, AR; Foster, MA
A role for folic acid conjugase in the regulation of methionine synthesis by Coprinus lagopus.
Biochim Biophys Acta
252
597-600
1971
Coprinopsis lagopus
Automatic Mining of ENzyme DAta
Hoffbrand, AV; Peters, TJ
The subcellular localization of pteroyl polyglutamate hydrolase and folate in guinea pig intestinal mucosa.
Biochim Biophys Acta
192
479-85
1969
Cavia porcellus
Automatic Mining of ENzyme DAta
Prescott, LM; Affronti, LF
Presence of conjugase activity in amethopterin-resistant Streptococcus faecium.
J Bacteriol
95
2422-3
1968
Enterococcus faecium
Automatic Mining of ENzyme DAta
Hoffbrand, AV; Peters, TJ
Subcellular localization of folate conjugase in guinea-pig intestinal mucosa.
J Physiol
202
40P
1969
Cavia porcellus
Automatic Mining of ENzyme DAta
Kesavan, V; Noronha, JM
Folate malabsorption in aged rats related to low levels of pancreatic folyl conjugase.
Am J Clin Nutr
37
262-7
1983
Rattus, Metazoa
Automatic Mining of ENzyme DAta
Leichter, J; Lee, M
Intestinal folate conjugase activity and folate absorption in the ethanol-fed pregnant rat.
Drug Nutr Interact
3
53-9
1984
Rattus, Metazoa
Automatic Mining of ENzyme DAta
Leichter, J; Krumdieck, CL
Effect of oral contraceptives on intestinal folate conjugase activity and folate absorption in rats.
Drug Nutr Interact
2
1-6
1983
Rattus, Metazoa, Oxalis tuberosa
Automatic Mining of ENzyme DAta
Li, WW; Waltham, M; Tong, W; Schweitzer, BI; Bertino, JR
Increased activity of gamma-glutamyl hydrolase in human sarcoma cell lines: a novel mechanism of intrinsic resistance to methotrexate (MTX).
Adv Exp Med Biol
338
635-8
1993
Homo sapiens
Automatic Mining of ENzyme DAta
Rao, KN
Denaturation of pteroylpoly-gamma-glutamyl hydrolase from chicken liver by urea, thiourea and guanidine hydrochloride: altered catalytic properties of the enzyme activated by urea.
Indian J Biochem Biophys
32
11-20
1995
Gallus gallus
Automatic Mining of ENzyme DAta
Yao, R; Nimec, Z; Ryan, TJ; Galivan, J
Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase.
J Biol Chem
271
8525-8
1996
Rattus
Automatic Mining of ENzyme DAta
Takemura, Y; Kobayashi, H; Sekiguchi, S
[Separation of methotrexate-polyglutamates by capillary electrophoresis and its application to the measurement of gamma-glutamyl hydrolase activity in human leukemia cells in culture]
Rinsho Byori
44
51-6
1996
Homo sapiens, clinical samples
Automatic Mining of ENzyme DAta
Yao, R; Schneider, E; Ryan, TJ; Galivan, J
Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro.
Proc Natl Acad Sci U S A
93
10134-8
1996
Homo sapiens, Rattus, Escherichia coli
Automatic Mining of ENzyme DAta
Huangpu, J; Pak, JH; Graham, MC; Rickle, SA; Graham, JS
Purification and molecular analysis of an extracellular gamma-glutamyl hydrolase present in young tissues of the soybean plant.
Biochem Biophys Res Commun
228
1-6
1996
Glycine max, plant, Arabidopsis, Rattus
Automatic Mining of ENzyme DAta
Waltham, MC; Li, WW; Gritsman, H; Tong, WP; Bertino, JR
gamma-Glutamyl hydrolase from human sarcoma HT-1080 cells: characterization and inhibition by glutamine antagonists.
Mol Pharmacol
51
825-32
1997
Homo sapiens, Rodentia
Automatic Mining of ENzyme DAta
Esaki, T; Roy, K; Yao, R; Galivan, J; Sirotnak, FM
Cloning of mouse gamma-glutamyl hydrolase in the form of two cDNA variants with different 5' ends and encoding alternate leader peptide sequences.
Gene
219
37-44
1998
Mus musculus, Homo sapiens, Rattus
Automatic Mining of ENzyme DAta
Esaki, T; Masumoto, N; Hayes, P; Chen, J; Sirotnak, FM
Organization and structure of the mouse gamma-glutamyl hydrolase gene and the functional identification of its promoter.
Gene
234
93-100
1999
Mus musculus
Automatic Mining of ENzyme DAta
Yin, D; Chave, KJ; Macaluso, CR; Galivan, J; Yao, R
Structural organization of the human gamma-glutamyl hydrolase gene.
Gene
238
463-70
1999
Homo sapiens
Automatic Mining of ENzyme DAta
Masumoto, N; Esaki, T; Sirotnak, FM
Additional organizational features of the murine gamma-glutamyl hydrolase gene. Two remotely situated exons within the complement C3 gene locus encode an alternate 5' end and proximal ORF under the control of a bidirectional promoter.
Gene
268
183-94
2001
Mus musculus
Automatic Mining of ENzyme DAta
Wing, JP; Schreader, BA; Yokokura, T; Wang, Y; Andrews, PS; Huseinovic, N; Dong, CK; Ogdahl, JL; Schwartz, LM; White, K; Nambu, JR
Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis.
Nat Cell Biol
4
451-6
2002
Drosophila
Automatic Mining of ENzyme DAta
Masumoto, N; Chen, J; Sirotnak, FM
Regulation of transcription of the murine gamma-glutamyl hydrolase gene. Delineation of core promoter A and the role of LYF-1, E2F and ETS-1 in determining tumor-specific expression.
Gene
291
169-76
2002
Mus musculus
Automatic Mining of ENzyme DAta
Yin, D; Galivan, J; Ao, W; Yao, R
Characterization of the human gamma-glutamyl hydrolase promoter and its gene expression in human tissues and cancer cell lines.
Gene
312
281-8
2003
Homo sapiens
Automatic Mining of ENzyme DAta
Chave, KJ; Ryan, TJ; Chmura, SE; Galivan, J
Identification of single nucleotide polymorphisms in the human gamma-glutamyl hydrolase gene and characterization of promoter polymorphisms.
Gene
319
167-75
2003
Homo sapiens, Rattus
Automatic Mining of ENzyme DAta
Wagner, KW; Sapinoso, LM; El-Rifai, W; Frierson, HF; Butz, N; Mestan, J; Hofmann, F; Deveraux, QL; Hampton, GM
Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin.
Oncogene
23
6621-9
2004
Homo sapiens
Automatic Mining of ENzyme DAta
Cheng, Q; Wu, B; Kager, L; Panetta, JC; Zheng, J; Pui, CH; Relling, MV; Evans, WE
A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells.
Pharmacogenetics
14
557-67
2004
Homo sapiens
Automatic Mining of ENzyme DAta
Chunhachart, O; Hanayama, T; Hidesaki, M; Tanimoto, H; Tahara, Y
Structure of the Hydrolyzed Product (F-2) Released from gamma-Polyglutamic Acid by gamma-Glutamyl Hydrolase YwtD of Bacillus subtilis.
Biosci Biotechnol Biochem
70
2289-91
2006
Bacillus subtilis
Automatic Mining of ENzyme DAta
Wolff, R; Drouet, L; Karlin, R
Occurrence of Vitamin Bc Conjugase in Human Plasma.
Science
109
612-613
1949
Homo sapiens
Automatic Mining of ENzyme DAta
Dabrowska, W; Kazenko, A; Laskowski, M
Concerning the Specificity of Chicken Pancreas Conjugase.
Science
110
95
1949
Gallus gallus
Automatic Mining of ENzyme DAta
Uthaman, SB; Godenschwege, TA; Murphey, RK
A mechanism distinct from highwire for the Drosophila ubiquitin conjugase bendless in synaptic growth and maturation.
J Neurosci
28
8615-23
2008
Drosophila
Automatic Mining of ENzyme DAta
OLSON, OE; FAGER, EE
The use of a hog kidney conjugase in the assay of plant materials for folic acid.
Arch Biochem
18
261-70
1948
plant
Automatic Mining of ENzyme DAta
KAZENKO, A; LASKOWSKI, M
On the specificity of chicken pancreas conjugase (gamma-glutamic acid carboxypeptidase).
J Biol Chem
173
217-21
1948
Gallus gallus
Automatic Mining of ENzyme DAta
SWENDSEID, ME; BROWN, RA
Comparative study of pteroylglutamic acid and its hexaglutamyl conjugate in the correction of sulfasuxidine-induced leucopenia in the rat; effect of conjugase inhibitor.
Arch Biochem
16
367-71
1948
Rattus
Automatic Mining of ENzyme DAta
Li, W; Schmidt, W
A lysine-63-linked ubiquitin chain-forming conjugase, UBC13, promotes the developmental responses to iron deficiency in Arabidopsis roots.
Plant J
62
330-43
2010
Arabidopsis
Automatic Mining of ENzyme DAta
MIMS, V; LASKOWSKI, M
Studies on vitamin Bc conjugase from chicken pancreas.
J Biol Chem
160
493-503
1945
Gallus gallus
Automatic Mining of ENzyme DAta
Cui, F; Liu, L; Zhao, Q; Zhang, Z; Li, Q; Lin, B; Wu, Y; Tang, S; Xie, Q
Arabidopsis Ubiquitin Conjugase UBC32 Is an ERAD Component That Functions in Brassinosteroid-Mediated Salt Stress Tolerance.
Plant Cell
24
233-44
2012
Arabidopsis
Automatic Mining of ENzyme DAta
Aguado-Llera, D; Domnech, R; Marenchino, M; Vidal, M; Neira, JL
Non-canonical residues of the marginally stable monomeric ubiquitin conjugase from goldfish are involved in binding to the C terminus of Ring 1B.
Biochim Biophys Acta
1824
991-1001
2012
Carassius auratus, Homo sapiens
Automatic Mining of ENzyme DAta
Knobbe, AR; Horken, KM; Plucinak, TM; Balassa, E; Cerutti, H; Weeks, DP
SUMOylation by a Stress-Specific Small Ubiquitin-Like Modifier E2 Conjugase Is Essential for Survival of Chlamydomonas reinhardtii under Stress Conditions.
Plant Physiol
167
753-65
2015
Chlamydomonas reinhardtii, eukaryota
Automatic Mining of ENzyme DAta
Ying, Y; Yue, W; Wang, S; Li, S; Wang, M; Zhao, Y; Wang, C; Mao, C; Whelan, J; Shou, H
Two h-Type Thioredoxins Interact with the E2 Ubiquitin Conjugase PHO2 to Fine-Tune Phosphate Homeostasis in Rice.
Plant Physiol
173
812-824
2017
Oryza sativa
Automatic Mining of ENzyme DAta
Sadahiro, S; Suzuki, T; Tanaka, A; Okada, K; Saito, G; Miyakita, H; Ogimi, T; Nagase, H
Gene expression levels of gamma-glutamyl hydrolase in tumor tissues may be a useful biomarker for the proper use of S-1 and tegafur-uracil/leucovorin in preoperative chemoradiotherapy for patients with rectal cancer.
Cancer Chemother Pharmacol
79
1077-1085
2017
Homo sapiens
Automatic Mining of ENzyme DAta
Ye, Y; Tyndall, ER; Bui, V; Tang, Z; Shen, Y; Jiang, X; Flanagan, JM; Wang, HG; Tian, F
An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy.
Nat Commun
12
374
2021
Homo sapiens
Automatic Mining of ENzyme DAta
Soongsongkiat M;Puwastien P;Jittinandana S;Dee-Uam A;Sungpuag P
Testing of folate conjugase from chicken pancreas vs. commercial enzyme and studying the effect of cooking on folate retention in Thai foods
Journal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems
23
681-688
2010
Gallus gallus, Glycine max, Oryza sativa, Asparagus
Automatic Mining of ENzyme DAta
Livant EJ;Tamura T;Johnston KE;Vaughn WH;Bergman SM;Forehand J;Walthaw J
Plasma folate conjugase activities and folate concentrations in patients receiving hemodialysis.
The Journal of nutritional biochemistry
5
504-508
1994
Homo sapiens
Automatic Mining of ENzyme DAta
Gujska, E; Majewska, K
Effect of baking process on added folic acid and endogenous folates stability in wheat and rye breads.
Plant Foods Hum Nutr
60
37-42
2005
Rattus
Automatic Mining of ENzyme DAta
Liu, TY; Huang, TK; Tseng, CY; Lai, YS; Lin, SI; Lin, WY; Chen, JW; Chiou, TJ
PHO2-dependent degradation of PHO1 modulates phosphate homeostasis in Arabidopsis.
Plant Cell
24
2168-83
2012
Nicotiana tabacum
Automatic Mining of ENzyme DAta
Szpylka, J; DeVries, J; Cheney, A; House, S
Determination of total folates in infant formula and adult nutritionals by trienzyme extraction and UPLC-MS/MS Quantitation: First Action 2011.06.
J AOAC Int
95
1547-54
0
Rattus, Homo sapiens
Automatic Mining of ENzyme DAta
Shrestha AK;Arcot J;Paterson J
Folate assay of foods by traditional and tri-enzyme treatments using cryoprotected Lactobacillus casei.
Food chemistry
71
545-552
2000
Gallus gallus, Homo sapiens
Automatic Mining of ENzyme DAta
Halsted, CH; Reisenauer, A; Back, C; Gotterer, GS
In vitro uptake and metabolism of pteroylpolyglutamate by rat small intestine.
J Nutr
106
485-92
1976
Rattus
Automatic Mining of ENzyme DAta
DeBari, VA; Frank, O; Baker, H; Needle, MA
Water soluble vitamins in granulocytes, erythrocytes, and plasma obtained from chronic hemodialysis patients.
Am J Clin Nutr
39
410-5
1984
Homo sapiens
Automatic Mining of ENzyme DAta
Sybesma, W; Van Den Born, E; Starrenburg, M; Mierau, I; Kleerebezem, M; De Vos, WM; Hugenholtz, J
Controlled modulation of folate polyglutamyl tail length by metabolic engineering of Lactococcus lactis.
Appl Environ Microbiol
69
7101-7
2003
Homo sapiens, Rattus, bacterium, Lactococcus lactis
Automatic Mining of ENzyme DAta
Pizzorno, G; Moroson, BA; Cashmore, AR; Russello, O; Mayer, JR; Galivan, J; Bunni, MA; Priest, DG; Beardsley, GP
Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM.
Cancer Res
55
566-73
1995
Homo sapiens, Mus musculus
Automatic Mining of ENzyme DAta
Odin, E; Wettergren, Y; Nilsson, S; Willén, R; Carlsson, G; Spears, CP; Larsson, L; Gustavsson, B
Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients.
Clin Cancer Res
9
6012-9
2003
Homo sapiens
Automatic Mining of ENzyme DAta
Bohl, CR; Abrahamyan, LG; Wood, C
Human Ubc9 is involved in intracellular HIV-1 Env stability after trafficking out of the trans-Golgi network in a Gag dependent manner.
PLoS One
8
e69359
2013
Human immunodeficiency virus 1
Automatic Mining of ENzyme DAta
O'Connor, DL; Tamura, T; Picciano, MF
Pteroylpolyglutamates in human milk.
Am J Clin Nutr
53
930-4
1991
Homo sapiens, Lacticaseibacillus casei
Automatic Mining of ENzyme DAta
Cooperman, JM; Dweck, HS; Newman, LJ; Garbarino, C; Lopez, R
The folate in human milk.
Am J Clin Nutr
36
576-80
1982
Homo sapiens, Lacticaseibacillus casei
Automatic Mining of ENzyme DAta
Bhandari, SD; Gregory, JF
Inhibition by selected food components of human and porcine intestinal pteroylpolyglutamate hydrolase activity.
Am J Clin Nutr
51
87-94
1990
Bos taurus, Brassica oleracea var. botrytis, Brassica oleracea var. capitata, Glycine max, Homo sapiens, Solanum lycopersicum, Sus scrofa
Automatic Mining of ENzyme DAta
Xu, Y; Mietkiewska, E; Shah, S; Weselake, RJ; Chen, G
Punicic acid production in Brassica napus.
Metab Eng
62
20-29
2020
Brassica napus, Punica granatum
Automatic Mining of ENzyme DAta
Wilson, SD; Horne, DW
Effect of nitrous oxide inactivation of vitamin B12 on the levels of folate coenzymes in rat bone marrow, kidney, brain, and liver.
Arch Biochem Biophys
244
248-53
1986
Lacticaseibacillus casei
Automatic Mining of ENzyme DAta
Krumdieck, CL; Boots, LR; Cornwell, PE; Butterworth, CE
Cyclic variations in folate composition and pteroylpolyglutamyl hydrolase (conjugase) activity of the rat uterus.
Am J Clin Nutr
29
288-94
1976
Rattus, Metazoa
Automatic Mining of ENzyme DAta
Ward, GJ; Nixon, PF
Modulation of pteroylpolyglutamate concentration and length in response to altered folate nutrition in a comprehensive range of rat tissues.
J Nutr
120
476-84
1990
Rattus, Lacticaseibacillus casei
Automatic Mining of ENzyme DAta
Priest, DG; Veronee, CD; Mangum, M; Bednarek, JM; Doig, MT
Comparison of folylpolyglutamate hydrolases of mouse liver, kidney, muscle and brain.
Mol Cell Biochem
43
81-7
1982
Mus musculus, Lacticaseibacillus casei
Automatic Mining of ENzyme DAta
Jekic, B; Lukovic, L; Bunjevacki, V; Milic, V; Novakovic, I; Damnjanovic, T; Milasin, J; Popovic, B; Maksimovic, N; Damjanov, N; Radunovic, G; Kovacevic, L; Krajinovic, M
Association of the TYMS 3G/3G genotype with poor response and GGH 354GG genotype with the bone marrow toxicity of the methotrexate in RA patients.
Eur J Clin Pharmacol
2012
Homo sapiens
Automatic Mining of ENzyme DAta
van Erp, H; Shockey, J; Zhang, M; Adhikari, N; Browse, JA
Reducing Isozyme Competition Increases Target Fatty Acid Accumulation in Seed Triacylglycerols of Transgenic Arabidopsis.
Plant Physiol
2015
Arabidopsis
Automatic Mining of ENzyme DAta
Jägerstad, M; Dencker, H; Westesson, AK
The hydrolysis and absorption of conjugated folates in man.
Scand J Gastroenterol
11
283-7
1976
Homo sapiens, Lacticaseibacillus casei, Senegalimassilia faecalis
Automatic Mining of ENzyme DAta
Richardson, RE; Healy, MJ; Nixon, PF
Folates of rat tissue. Bioassay of tissue folylpolyglutamates and a relationship of liver folypolyglutamates to nutritional folate sufficiency.
Biochim Biophys Acta
585
128-33
1979
Rattus
Automatic Mining of ENzyme DAta
Tamura, T; Shane, B; Baer, MT; King, JC; Margen, S; Stokstad, EL
Absorption of mono- and polyglutamyl folates in zinc-depleted man.
Am J Clin Nutr
31
1984-7
1978
Homo sapiens
Automatic Mining of ENzyme DAta
Davidson, GE; Weir, DG; Scott, JM
The metabolic consequences of vitamin B-12/methionine deficiency in rats.
Biochim Biophys Acta
392
207-15
1975
Metazoa
Automatic Mining of ENzyme DAta
Grossowicz, N; Rachmilewitz, M; Izak, G
Utilization of yeast polyglutamate folates in man.
Proc Soc Exp Biol Med
150
77-9
1975
Saccharomyces cerevisiae
Automatic Mining of ENzyme DAta
Comley, JC; Mullin, RJ; Wolfe, LA; Hanlon, MH; Ferone, R
Microculture screening assay for primary in vitro evaluation of drugs against Pneumocystis carinii.
Antimicrob Agents Chemother
35
1965-74
1991
Pneumocystis carinii, Rattus
Automatic Mining of ENzyme DAta
Keating, JN; Weir, DG; Scott, JM
The effect of ethanol consumption on folate polyglutamate biosynthesis in the rat.
Biochem Pharmacol
34
1913-6
1985
Metazoa
Automatic Mining of ENzyme DAta
Wilson, SD; Horne, DW
High-performance liquid chromatographic determination of the distribution of naturally occurring folic acid derivatives in rat liver.
Anal Biochem
142
529-35
1984
Lacticaseibacillus casei
Automatic Mining of ENzyme DAta
Bailey, LB; Cerda, JJ; Bloch, BS; Busby, MJ; Vargas, L; Chandler, CJ; Halsted, CH
Effect of age on poly- and monoglutamyl folacin absorption in human subjects.
J Nutr
114
1770-6
1984
Homo sapiens
Automatic Mining of ENzyme DAta
Connor, MJ; Blair, JA
The identification of the folate conjugates found in rat liver 48 h after the administration of radioactively labelled folate tracers.
Biochem J
186
235-42
1980
Rattus
Automatic Mining of ENzyme DAta
Roomi, MW; Farber, E; Parke, DV
Changes in drug-metabolizing enzymes of rats in ciprofibrate-induced hepatic nodules.
Xenobiotica
27
951-60
1997
Rattus
Automatic Mining of ENzyme DAta
Nakata, R
Determination of folate derivatives in rat tissues during folate deficiency.
J Nutr Sci Vitaminol (Tokyo)
46
215-21
2000
Rattus
Automatic Mining of ENzyme DAta
Thomas, PM; Flanagan, VP; Pawlosky, RJ
Determination of 5-methyltetrahydrofolic acid and folic acid in citrus juices using stable isotope dilution-mass spectrometry.
J Agric Food Chem
51
1293-6
2003
Rattus
Automatic Mining of ENzyme DAta
Kimura, K; Itoh, Y
Characterization of poly-gamma-glutamate hydrolase encoded by a bacteriophage genome: possible role in phage infection of Bacillus subtilis encapsulated with poly-gamma-glutamate.
Appl Environ Microbiol
69
2491-7
2003
Bacillus subtilis, Bacteriophage sp., Bacillus phage phiNIT1, Chelator
Automatic Mining of ENzyme DAta
Schreader, BA; Wang, Y; Nambu, JR
Drosophila morgue and the intersection between protein ubiquitination and programmed cell death.
Apoptosis
8
129-39
2003
Intracisternal A-particles
Automatic Mining of ENzyme DAta
Kim, TH; Yang, J; Darling, PB; O'Connor, DL
A large pool of available folate exists in the large intestine of human infants and piglets.
J Nutr
134
1389-94
2004
Homo sapiens
Automatic Mining of ENzyme DAta
Patring, JD; Jastrebova, JA; Hjortmo, SB; Andlid, TA; Jägerstad, IM
Development of a simplified method for the determination of folates in baker's yeast by HPLC with ultraviolet and fluorescence detection.
J Agric Food Chem
53
2406-11
2005
Saccharomyces cerevisiae, Rattus
Automatic Mining of ENzyme DAta
Peng, M; Hannam, C; Gu, H; Bi, YM; Rothstein, SJ
A mutation in NLA, which encodes a RING-type ubiquitin ligase, disrupts the adaptability of Arabidopsis to nitrogen limitation.
Plant J
50
320-37
2007
Arabidopsis
Automatic Mining of ENzyme DAta
Koba, K; Imamura, J; Akashoshi, A; Kohno-Murase, J; Nishizono, S; Iwabuchi, M; Tanaka, K; Sugano, M
Genetically modified rapeseed oil containing cis-9,trans-11,cis-13-octadecatrienoic acid affects body fat mass and lipid metabolism in mice.
J Agric Food Chem
55
3741-8
2007
Trichosanthes kirilowii, plant
Automatic Mining of ENzyme DAta
Mutiu, AI; Hoke, SM; Genereaux, J; Liang, G; Brandl, CJ
The role of histone ubiquitylation and deubiquitylation in gene expression as determined by the analysis of an HTB1(K123R) Saccharomyces cerevisiae strain.
Mol Genet Genomics
277
491-506
2007
Saccharomyces cerevisiae
Automatic Mining of ENzyme DAta
Inoue, S; Hashiguchi, M; Kawai, S; Mochizuki, M
Erythrocyte methotrexate-polyglutamate assay using fluorescence polarization immunoassay technique: application to the monitoring of patients with rheumatoid arthritis.
Yakugaku Zasshi
129
1001-5
2009
Homo sapiens
Automatic Mining of ENzyme DAta
Munyaka, AW; Verlinde, P; Mukisa, IM; Oey, I; Van Loey, A; Hendrickx, M
Influence of thermal processing on hydrolysis and stability of folate poly-gamma-glutamates in broccoli (Brassica oleracea var. italica), carrot (Daucus carota) and tomato (Lycopersicon esculentum).
J Agric Food Chem
58
4230-40
2010
Daucus carota, Solanum lycopersicum, Brassica oleracea var. italica
Automatic Mining of ENzyme DAta
Akhtar, TA; Orsomando, G; Mehrshahi, P; Lara-Nez, A; Bennett, MJ; Gregory, JF; Hanson, AD
A central role for gamma-glutamyl hydrolases in plant folate homeostasis.
Plant J
64
256-66
2010
plant, Arabidopsis, Solanum lycopersicum
Automatic Mining of ENzyme DAta
Pan, IC; Schmidt, W
Functional implications of K63-linked ubiquitination in the iron deficiency response of Arabidopsis roots.
Front Plant Sci
4
542
2014
eukaryota
Automatic Mining of ENzyme DAta
Song, Z; Mietkiewska, E; Weselake, RJ
The linin promoter is highly effective in enhancing punicic acid production in Arabidopsis.
Plant Cell Rep
36
447-457
2017
Arabidopsis, Punica granatum
Automatic Mining of ENzyme DAta
Garaiova, M; Mietkiewska, E; Weselake, RJ; Holic, R
Metabolic engineering of Schizosaccharomyces pombe to produce punicic acid, a conjugated fatty acid with nutraceutic properties.
Appl Microbiol Biotechnol
2017
Arabidopsis thaliana, Punica granatum, plant
Automatic Mining of ENzyme DAta
Koseki, K; Okamoto, N; Bito, T; Ebara, S; Yabuta, Y; Watanabe, F
Growth Response of Lactobacillus rhamnosus Chloramphenicol-Resistant Strain ATCC 27773 to Pteroyl-Mono- and -Di-Glutamates.
J Nutr Sci Vitaminol (Tokyo)
65
545-549
2019
Lacticaseibacillus rhamnosus, Gallus gallus
Automatic Mining of ENzyme DAta
Ramos-Parra PA;Urrea-Lpez R;Daz de la Garza RI
Folate analysis in complex food matrices: Use of a recombinant Arabidopsis ?-glutamyl hydrolase for folate deglutamylation
Food research international (Ottawa, Ont.)
54
177-185
2013
Medicago sativa, Solanum lycopersicum, Rattus, plant
Automatic Mining of ENzyme DAta
Aiso, K; Tamura, T
Trienzyme treatment for food folate analysis: optimal pH and incubation time for alpha-amylase and protease treatment.
J Nutr Sci Vitaminol (Tokyo)
44
361-70
1998
Spinacia oleracea, Bos taurus
Automatic Mining of ENzyme DAta
Kim, JS; Lowe, KE; Shane, B
Regulation of folate and one-carbon metabolism in mammalian cells. IV. Role of folylpoly-gamma-glutamate synthetase in methotrexate metabolism and cytotoxicity.
J Biol Chem
268
21680-5
1993
Escherichia coli, Homo sapiens, Cricetulus griseus
Automatic Mining of ENzyme DAta
Galivan, J; Johnson, T; Rhee, M; McGuire, JJ; Priest, D; Kesevan, V
The role of folylpolyglutamate synthetase and gamma-glutamyl hydrolase in altering cellular folyl- and antifolylpolyglutamates.
Adv Enzyme Regul
26
147-55
1987
Homo sapiens, Rodentia
Automatic Mining of ENzyme DAta
Longo, GS; Gorlick, R; Tong, WP; Lin, S; Steinherz, P; Bertino, JR
gamma-Glutamyl hydrolase and folylpolyglutamate synthetase activities predict polyglutamylation of methotrexate in acute leukemias.
Oncol Res
9
259-63
1997
Homo sapiens
Automatic Mining of ENzyme DAta
Ding, JL; Smith, GD; Searle, A; Peters, TJ
In situ determination of the molecular weight of hepatic gamma-glutamyl transferase and gamma-glutamyl hydrolase activities.
Biochim Biophys Acta
707
164-6
1982
Rattus
Automatic Mining of ENzyme DAta
Williams, K; Cullati, S; Sand, A; Biterova, EI; Barycki, JJ
Crystal Structure of Acivicin-Inhibited gamma-Glutamyltranspeptidase Reveals Critical Roles for Its C-Terminus in Autoprocessing and Catalysis (dagger) (double dagger).
Biochemistry
48
2459-67
2009
Helicobacter pylori
Automatic Mining of ENzyme DAta
Lakshmaiah, N; Ramasastri, BV
Folic acid conjugase from Plasma. I. Partial purification and properties.
Int J Vitam Nutr Res
45
183-93
1975
Bos taurus, Canis lupus familiaris, Capra hircus, Cavia porcellus, Homo sapiens, Lacticaseibacillus casei, Metazoa, Oryctolagus cuniculus, Platyrrhini, Rattus, Saccharomyces cerevisiae, Senegalimassilia faecalis
Automatic Mining of ENzyme DAta
Lakshmaiah, N; Ramasastri, BV
Folic acid conjugase from plasma. II. Studies on the source of the enzyme in blood.
Int J Vitam Nutr Res
45
194-200
1975
Rattus, Metazoa
Automatic Mining of ENzyme DAta
Lakshmaiah, N; Ramasastri, BV
Folic acid conjugase from plasma. III. Use of the enzyme in the estimation of folate activity in foods.
Int J Vitam Nutr Res
45
262-72
1975
Gallus gallus, Homo sapiens, Rattus, Canis lupus familiaris, Bos taurus, Capra hircus, animal, plant
Automatic Mining of ENzyme DAta
Leichter, J; Landymore, AF; Krumdieck, CL
Folate conjugase activity in fresh vegetables and its effect on the determination of free folate content.
Am J Clin Nutr
32
92-5
1979
Gallus gallus, Lacticaseibacillus casei, Spinacia oleracea, Brassica oleracea var. botrytis, Brassica oleracea var. capitata, Brassica oleracea var. italica, Brassica oleracea var. gemmifera
Automatic Mining of ENzyme DAta
Wagh, PV; Kalman, TI
A rapid colorimetric assay for gamma-glutamyl hydrolase (conjugase).
Anal Biochem
207
1-5
1992
Gallus gallus
Automatic Mining of ENzyme DAta
O'Connor, BM; Rotundo, RF; Nimec, Z; McGuire, JJ; Galivan, J
Secretion of gamma-glutamyl hydrolase in vitro.
Cancer Res
51
3874-81
1991
Homo sapiens, Rattus
Automatic Mining of ENzyme DAta
Pedersen, JC
Comparison of gamma-glutamyl hydrolase (conjugase; EC 3.4.22.12) and amylase treatment procedures in the microbiological assay for food folates.
Br J Nutr
59
261-71
1988
Pisum sativum, Solanum tuberosum, Gallus gallus, Sus scrofa, Lacticaseibacillus casei, Avena sativa, Secale cereale, Triticum aestivum, test organism
Automatic Mining of ENzyme DAta
Sur, P; Priest, DG; Doig, MT
Effects of growth rate and methotrexate on folate polyglutamates and folylpolyglutamate hydrolase activity in Krebs ascites cells.
Biochem Cell Biol
64
363-7
1986
Mus sp.
Automatic Mining of ENzyme DAta
Wang, Y; Dias, JA; Nimec, Z; Rotundo, R; O'Connor, BM; Freisheim, J; Galivan, J
The properties and function of gamma-glutamyl hydrolase and poly-gamma-glutamate.
Adv Enzyme Regul
33
207-18
1993
Rattus
Automatic Mining of ENzyme DAta
Cole, PD; Kamen, BA; Gorlick, R; Banerjee, D; Smith, AK; Magill, E; Bertino, JR
Effects of overexpression of gamma-Glutamyl hydrolase on methotrexate metabolism and resistance.
Cancer Res
61
4599-604
2001
Homo sapiens, Rattus
Automatic Mining of ENzyme DAta
Pankuch, JJ; Coward, JK
N-Me-pAB-Glu-gamma-Glu-gamma-Tyr(3-NO(2)): an internally quenched fluorogenic gamma-glutamyl hydrolase substrate.
Bioorg Med Chem Lett
11
1561-4
2001
Rattus
Automatic Mining of ENzyme DAta
Panetta, JC; Wall, A; Pui, CH; Relling, MV; Evans, WE
Methotrexate intracellular disposition in acute lymphoblastic leukemia: a mathematical model of gamma-glutamyl hydrolase activity.
Clin Cancer Res
8
2423-9
2002
Homo sapiens
Automatic Mining of ENzyme DAta
Li, Y; Lu, J; Prochownik, EV
Dual role for SUMO E2 conjugase Ubc9 in modulating the transforming and growth-promoting properties of the HMGA1b architectural transcription factor.
J Biol Chem
282
13363-71
2007
Saccharomyces cerevisiae
Automatic Mining of ENzyme DAta
Jiang, TT; Wang, C; Wei, LL; Yu, XM; Shi, LY; Xu, DD; Chen, ZL; Ping, ZP; Li, JC
Serum protein gamma-glutamyl hydrolase, Ig gamma-3 chain C region, and haptoglobin are associated with the syndromes of pulmonary tuberculosis in traditional Chinese medicine.
BMC Complement Altern Med
15
243
2015
Mycobacterium, Homo sapiens
Automatic Mining of ENzyme DAta
Zhang, J; Kinch, LN; Cong, Q; Weile, J; Sun, S; Cote, AG; Roth, FP; Grishin, NV
Assessing predictions of fitness effects of missense mutations in SUMO-conjugating enzyme UBE2I.
Hum Mutat
38
1051-1063
2017
Homo sapiens
Automatic Mining of ENzyme DAta
Arvand, A; Bastians, H; Welford, SM; Thompson, AD; Ruderman, JV; Denny, CT
EWS/FLI1 up regulates mE2-C, a cyclin-selective ubiquitin conjugating enzyme involved in cyclin B destruction.
Oncogene
17
2039-45
1998
Mus musculus
Automatic Mining of ENzyme DAta
Ndaw, S; Bergaentzlé, M; Aoudé-Werner, D; Lahély, S; Hasselmann, C
Determination of folates in foods by high-performance liquid chromatography with fluorescence detection after precolumn conversion to 5-methyltetrahydrofolates.
J Chromatogr A
928
77-90
2001
Spinacia oleracea, Gallus gallus, Bos taurus, Rattus
Automatic Mining of ENzyme DAta
Rader JI;Weaver CM;Angyal G
Use of a microbiological assay with tri-enzyme extraction for measurement of pre-fortification levels of folates in enriched cereal-grain products.
Food chemistry
62
451-465
1998
Gallus gallus
Automatic Mining of ENzyme DAta
Martin, JI; Landen, WO; Soliman, AG; Eitenmiller, RR
Application of a tri-enzyme extraction for total folate determination in foods.
J Assoc Off Anal Chem
73
805-8
0
Gallus gallus, Chondrichthyes, Scombridae gen. sp.
Automatic Mining of ENzyme DAta
McGuire, JJ; Hsieh, P; Coward, JK; Bertino, JR
Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products.
J Biol Chem
255
5776-88
1980
Rattus
Automatic Mining of ENzyme DAta
Costi, MP; Ferrari, S
Update on antifolate drugs targets.
Curr Drug Targets
2
135-66
2001
Homo sapiens
Automatic Mining of ENzyme DAta
Gorlick, R; Cole, P; Banerjee, D; Longo, G; Li, WW; Hochhauser, D; Bertino, JR
Mechanisms of methotrexate resistance in acute leukemia. Decreased transport and polyglutamylation.
Adv Exp Med Biol
457
543-50
1999
Homo sapiens
Automatic Mining of ENzyme DAta
Wani, NA; Hamid, A; Kaur, J
Alcohol-associated folate disturbances result in altered methylation of folate-regulating genes.
Mol Cell Biochem
363
157-66
2012
Rattus
Automatic Mining of ENzyme DAta
Karube, Y; Kobayashi, S; Maeda, S; Sado, T; Ishihama, H; Chida, M
Tumor-related gene expression levels in thymic carcinoma and Type B3 thymoma.
J Cardiothorac Surg
11
85
2016
Homo sapiens
Automatic Mining of ENzyme DAta
Liu, J; Pickford, R; Meagher, AP; Ward, RL
Quantitative analysis of tissue folate using ultra high-performance liquid chromatography tandem mass spectrometry.
Anal Biochem
411
210-7
2011
Homo sapiens
Automatic Mining of ENzyme DAta
Halsted, CH; Beer, WH; Chandler, CJ; Ross, K; Wolfe, BM; Bailey, L; Cerda, JJ
Clinical studies of intestinal folate conjugases.
J Lab Clin Med
107
228-32
1986
Homo sapiens
Automatic Mining of ENzyme DAta
Corcino, JJ; Reisenauer, AM; Halsted, CH
Jejunal Perfusion of Simple and Conjugated Folates in Tropical Sprue.
J Clin Invest
58
298-305
1976
Homo sapiens
Automatic Mining of ENzyme DAta
Li, W; Schmidt, W
Non-proteolytic protein ubiquitination is crucial for iron deficiency signaling.
Plant Signal Behav
5
2010
Arabidopsis, Cucumis sativus
Automatic Mining of ENzyme DAta
Bouvrette, P; Ziomek, E
Use of delta-(alpha-aminoadipoyl) chromogenic amides in screening for aminoadipoyl amidohydrolases.
Anal Biochem
200
315-20
1992
Xanthomonas, bacterium
Automatic Mining of ENzyme DAta
Halsted, CH; Reisenauer, AM; Romero, JJ; Cantor, DS; Ruebner, B
Jejunal perfusion of simple and conjugated folates in celiac sprue.
J Clin Invest
59
933-40
1977
Homo sapiens
Automatic Mining of ENzyme DAta
Herrlinger, KR; Cummings, JR; Barnardo, MC; Schwab, M; Ahmad, T; Jewell, DP
The pharmacogenetics of methotrexate in inflammatory bowel disease.
Pharmacogenet Genomics
15
705-11
2005
Homo sapiens
Automatic Mining of ENzyme DAta
Warren, RB; Smith, RL; Campalani, E; Eyre, S; Smith, CH; Barker, JN; Worthington, J; Griffiths, CE
Outcomes of methotrexate therapy for psoriasis and relationship to genetic polymorphisms.
Br J Dermatol
160
438-41
2009
Homo sapiens
Automatic Mining of ENzyme DAta
Nair, MG; Nanavati, NT; Kumar, P; Gaumont, Y; Kisliuk, RL
Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin.
J Med Chem
31
181-5
1988
Homo sapiens, Mus musculus, Enterococcus faecium, Lacticaseibacillus casei
Automatic Mining of ENzyme DAta
Chen, L; Eitenmiller, RR
Single laboratory method performance evaluation for the analysis of total food folate by trienzyme extraction and microplate assay.
J Food Sci
72
C243-7
2007
Gallus gallus, Lacticaseibacillus casei
Automatic Mining of ENzyme DAta
Pfeiffer CM;Rogers LM;Gregory JFIII
Determination of folate in cereal-grain food products using trienzyme extraction and combined affinity and reversed-phase liquid chromatography. [Erratum: July 1997, v. 45 (7), p. 2814.]
Journal of agricultural and food chemistry
45
407-413
1997
Oryza sativa, Rattus
Automatic Mining of ENzyme DAta
Mittal, MK; Singh, K; Misra, S; Chaudhuri, G
Slug-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination.
J Biol Chem
2010
Homo sapiens
Automatic Mining of ENzyme DAta
Rebello, T
Trace enrichment of biological folates on solid-phase adsorption cartridges and analysis by high-pressure liquid chromatography.
Anal Biochem
166
55-64
1987
Rattus
Automatic Mining of ENzyme DAta
Kashani, SA; Cooper, BA
Endogenous folate of normal fibroblasts using high-performance liquid chromatography and modified extraction procedure.
Anal Biochem
146
40-7
1985
Rattus
Automatic Mining of ENzyme DAta
Gregory, JF; Sartain, DB; Day, BP
Fluorometric determination of folacin in biological materials using high performance liquid chromatography.
J Nutr
114
341-53
1984
Lacticaseibacillus casei, Rattus
Automatic Mining of ENzyme DAta
Duch, DS; Bowers, SW; Nichol, CA
Analysis of folate cofactor levels in tissues using high-performance liquid chromatography.
Anal Biochem
130
385-92
1983
Rattus
Automatic Mining of ENzyme DAta
Galivan, J; Rhee, MS
Insulin-dependent suppression in glutamyl hydrolase activity and elevated cellular methotrexate polyglutamates.
Biochem Pharmacol
50
1659-63
1995
Rattus
Automatic Mining of ENzyme DAta
Doherty, RF; Beecher, GR
A method for the analysis of natural and synthetic folate in foods.
J Agric Food Chem
51
354-61
2003
Rattus, Homo sapiens
Automatic Mining of ENzyme DAta
Póo-Prieto, R; Haytowitz, DB; Holden, JM; Rogers, G; Choumenkovitch, SF; Jacques, PF; Selhub, J
Use of the affinity/HPLC method for quantitative estimation of folic acid in enriched cereal-grain products.
J Nutr
136
3079-83
2006
Rattus
Automatic Mining of ENzyme DAta
Zhou, Y; Carpenter, ZW; Brennan, G; Nambu, JR
The unique Morgue ubiquitination protein is conserved in a diverse but restricted set of invertebrates.
Mol Biol Evol
26
2245-59
2009
Nematodes, animal
Automatic Mining of ENzyme DAta
Zou, Y; Duan, H; Li, L; Chen, X; Wang, C
Quantification of polyglutamyl 5-methyltetrahydrofolate, monoglutamyl folate vitamers, and total folates in different berries and berry juice by UHPLC-MS/MS.
Food Chem
276
1-8
2019
Homo sapiens
Automatic Mining of ENzyme DAta
Xiong, Y; Yi, Y; Wang, Y; Yang, N; Rudd, CE; Liu, H
Ubc9 Interacts with and SUMOylates the TCR Adaptor SLP-76 for NFAT Transcription in T Cells.
J Immunol
203
3023-3036
2019
Homo sapiens, Mus musculus
Automatic Mining of ENzyme DAta