Reference on EC 3.4.19.9 - folate gamma-glutamyl hydrolase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rao, K.N.; Noronha, J.M.
Studies on the enzymatic hydrolysis of polyglutamyl folates by chicken liver folyl poly-gamma-glutamyl carboxypeptidase. I. Intracellular localization, purification and partial characterization of the enzyme
Biochim. Biophys. Acta
481
594-607
1977
Gallus gallus
Rao, K.N.; Noronha, J.M.
Studies on the enzymatic hydrolysis of polyglutamyl folates by chicken liver folyl poly-gamma-glutamyl carboxypeptidase. II. Structural studies
Biochim. Biophys. Acta
481
608-616
1977
Gallus gallus
Elsenhans, B.; Ahmad, O.; Rosenberg, I.H.
Isolation and characterization of pteroylpolyglutamate hydrolase from rat intestinal mucosa
J. Biol. Chem.
259
6364-6368
1984
Rattus norvegicus
Baugh, C.M.; Stevens, J.C.; Krumdieck, C.L.
Studies on gamma-glutamyl carboxypeptidase. I. The solid phase synthesis of analogs of polyglutamates of folic acid and their effects on human liver gamma-glutamyl carboxypeptidase
Biochim. Biophys. Acta
212
116-125
1970
Homo sapiens
Silink, M.; Reddel, R.; Bethel, M.; Rowe, P.B.
Gamma-glutamyl hydrolase conjugase. Purification and properties of the bovine hepatic enzyme
J. Biol. Chem.
250
5982-5994
1975
Bos taurus
Lakshmaiah, N.; Ramasastri, B.V.
Plasma folic acid conjugase
Methods Enzymol.
66
670-678
1980
Homo sapiens
Reisenauer, A.M.
Folate conjugase: two separate activities in human jejunum
Science
198
196-197
1977
Homo sapiens
Muro, T.; Nagamori, Y.; Okada, S.; Tominaga, Y.
Some properties and action of poly(glutamic acid) hydrolase II from Micromonospora melanosporea IFO 12515
Agric. Biol. Chem.
54
1065-1067
1990
Micromonospora melanosporea
Lin, S.; Rogiers, S.; Cossins, E.A.
gamma-Glutamyl hydrolase from pea cotyledons
Phytochemistry
32
1109-1117
1993
Pisum sativum
-
Wang, Y.; Nimec, Z.; Ryan, T.J.; Dias, J.A.; Galivan, J.
The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells
Biochim. Biophys. Acta
1164
227-235
1993
Rattus norvegicus
Tanaka, T.; Hiruta, O.; Futamura, T.; Uotani, K.; Satoh, A.; Taniguchi, M.; Or, S.
Purification and characterization of poly(g-glutamic acid) hydrolase from a filamentous fungus, Myrothecium sp. TM-4222
Biosci. Biotechnol. Biochem.
57
2148-2153
1993
Myrothecium sp., Myrothecium sp. TM-4222
-
Kferstein, H.; Jaenicke, L.
Gamma glutamyl carboxypeptidase from chicken pancreas
Hoppe-Seyler's Z. Physiol. Chem.
353
1153-1158
1972
Gallus gallus
Reisenauer, A.M.; Halsted, C.H.
Human jejunal brush border folate conjugase. Characteristics and inhibition by salicylazosulfapyridine
Biochim. Biophys. Acta
659
62-69
1981
Homo sapiens
Horne, D.W.; Krumdieck, C.L.; Wagner, C.
Properties of folic acid gamma-glutamyl hydrolase (conjugase) in rat bile and plasma
J. Nutr.
111
442-449
1981
Rattus norvegicus
Hartley, D.M.; Snodgrass, S.R.; Bradshaw, P.A.
The measurement of gamma-glutamyl hydrolase (conjugase) activity in rat brain
Neurochem. Res.
13
147-151
1988
Rattus norvegicus
Chandler, C.J.; Wang, T.T.Y.; Halsted, C.H.
Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization
J. Biol. Chem.
261
928-933
1986
Homo sapiens
Lavoie, A.; Tripp, E.; Hoffbrand, A.V.
Sephadex-gel filtration and heat stability of human jejunal and serum pteroylpolyglutamate hydrolase (folate conjugase). Evidence for two different forms
Biochem. Med.
13
1-6
1975
Homo sapiens
Wang, T.T.Y.; Chandler, C.J.; Halsted, C.H.
Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization
J. Biol. Chem.
261
13551-13555
1986
Homo sapiens
Krungkrai, J.; Yuthavong, Y.; Webster, H.K.
High-performance liquid chromatographic assay for pteroylpolyglutamate hydrolase
J. Chromatogr.
417
47-56
1987
Homo sapiens
Elsenhans, B.; Selhub, J.; Rosenberg, I.H.
Assay of folylpolyglutamate hydrolase using pteroyl-labeled substrates and selective short-term bacterial uptake for product determination
Methods Enzymol.
66
663-666
1980
Rattus norvegicus
Rosenberg, I.H.; Saini, P.K.
Folylpolyglutamate endopeptidase from chicken intestine: isolation with the aid of affinity chromatography
Methods Enzymol.
66
667-670
1980
Gallus gallus
Leichter, J.; Butterworth, C.E.Jr.; Krumdieck, C.L.
Partial purification and some properties of pteroylpolyglutamate hydrolase (conjugase) from chicken pancreas
Proc. Soc. Exp. Biol. Med.
154
98-101
1977
Gallus gallus
Bhandari, S.D.; Gregory, J.F.3rd.; Renuart, D.R.; Merritt, A.M.
Properties of pteroylpolyglutamate hydrolase in pancreatic juice of the pig
J. Nutr.
120
467-475
1990
Sus scrofa
Gregory, J.F.3rd.; Ink, S.L.; Cerda, J.J.
Comparison of pteroylpolyglutamate hydrolase (folate conjugase) from porcine and human intestinal brush border membrane
Comp. Biochem. Physiol. B
88
1135-1141
1987
Homo sapiens, Sus scrofa
Samuels, L.L.; Goutas, L.J.; Priest, D.G.; Piper, J.R.; Sirotnak, F.M.
Hydrolytic cleavage of methotrexate gamma-polyglutamates by folylpolyglutamyl hydrolase derived from various tumors and normal tissues of the mouse
Cancer Res.
46
2230-2235
1986
Mus musculus
Jaegerstad, M.; Olsson, I.
Pteroylpolyglutamate hydrolase of human granulocytes. I. Partial purification and kinetic studies
Scand. J. Clin. Lab. Invest.
39
343-349
1979
Homo sapiens
Chave, K.J.; Auger, I.E.; Galivan, J.; Ryan, T.J.
Molecular modeling and site-directed mutagenesis define the catalytic motif in human gamma -glutamyl hydrolase
J. Biol. Chem.
275
40365-40370
2000
Homo sapiens
Galivan, J.; Ryan, T.J.; Chave, K.; Rhee, M.; Yao, R.; Yin, D.
Glutamyl hydrolase: pharmacological role and enzymatic characterization
Pharmacol. Ther.
85
207-215
2000
Homo sapiens
Chave, K.J.; Galivan, J.; Ryan, T.J.
Site-directed mutagenesis establishes cysteine-110 as essential for enzyme activity in human gamma-glutamyl hydrolase
Biochem. J.
343
551-555
1999
Homo sapiens
Rhee, M.S.; Lindau-Shepard, B.; Chave, K.J.; Galivan, J.; Ryan, T.J.
Characterization of human cellular gamma-glutamyl hydrolase
Mol. Pharmacol.
53
1040-1046
1998
Homo sapiens
Li, H.; Ryan, T.J.; Chave, K.J.; Van Roey, P.
Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substrate
J. Biol. Chem.
277
24522-24529
2002
Homo sapiens
He, P.; Varticovski, L.; Bowman, E.D.; Fukuoka, J.; Welsh, J.A.; Miura, K.; Jen, J.; Gabrielson, E.; Brambilla, E.; Travis, W.D.; Harris, C.C.
Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray
Hum. Pathol.
35
1196-1209
2004
Homo sapiens
Orsomando, G.; de la Garza, R.D.; Green, B.J.; Peng, M.; Rea, P.A.; Ryan, T.J.; Gregory, J.F.; Hanson, A.D.
Plant gamma-glutamyl hydrolases and folate polyglutamates: characterization, compartmentation, and co-occurrence in vacuoles
J. Biol. Chem.
280
28877-28884
2005
Beta vulgaris, Pisum sativum, Arabidopsis thaliana (O65355)
Cheng, Q.; Cheng, C.; Crews, K.R.; Ribeiro, R.C.; Pui, C.H.; Relling, M.V.; Evans, W.E.
Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells
Am. J. Hum. Genet.
79
264-274
2006
Homo sapiens
Scorpio, A.; Chabot, D.J.; Day, W.A.; Obrien, D.K.; Vietri, N.J.; Itoh, Y.; Mohamadzadeh, M.; Friedlander, A.M.
Poly-gamma-glutamate capsule-degrading enzyme treatment enhances phagocytosis and killing of encapsulated Bacillus anthracis
Antimicrob. Agents Chemother.
51
215-222
2007
Bacillus phage phiNIT1
Alexander, J.P.; Ryan, T.J.; Ballou, D.P.; Coward, J.K.
Gamma-glutamyl hydrolase: kinetic characterization of isopeptide hydrolysis using fluorogenic substrates
Biochemistry
47
1228-1239
2008
Rattus norvegicus
Eisele, L.E.; Chave, K.J.; Lehning, A.C.; Ryan, T.J.
Characterization of human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer
Biochim. Biophys. Acta
1764
1479-1486
2006
Homo sapiens, Rattus norvegicus (Q62867)
Hayashi, H.; Fujimaki, C.; Inoue, K.; Suzuki, T.; Itoh, K.
Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population
Biol. Pharm. Bull.
30
839-841
2007
Homo sapiens
Chunhachart, O.; Itoh, T.; Sukchotiratana, M.; Tanimoto, H.; Tahara, Y.
Characterization of gamma-glutamyl hydrolase produced by Bacillus sp. isolated from Thai Thua-nao
Biosci. Biotechnol. Biochem.
70
2779-2782
2006
Bacillus sp. (in: Bacteria)
Kawakami, K.; Ooyama, A.; Ruszkiewicz, A.; Jin, M.; Watanabe, G.; Moore, J.; Oka, T.; Iacopetta, B.; Minamoto, T.
Low expression of gamma-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype
Br. J. Cancer
98
1555-1561
2008
Homo sapiens (Q92820)
Schneider, E.; Ryan, T.J.
Gamma-glutamyl hydrolase and drug resistance
Clin. Chim. Acta
374
25-32
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Chen, L.; Eitenmiller, R.R.
Optimization of the trienzyme extraction for the microbiological assay of folate in vegetables
J. Agric. Food Chem.
55
3884-3888
2007
Gallus gallus
Shafizadeh, T.B.; Halsted, C.H.
gamma-Glutamyl hydrolase, not glutamate carboxypeptidase II, hydrolyzes dietary folate in rat small intestine
J. Nutr.
137
1149-1153
2007
Rattus norvegicus
Kao, T.T.; Chang, W.N.; Wu, H.L.; Shi, G.Y.; Fu, T.F.
Recombinant zebrafish gamma-glutamyl hydrolase exhibits properties and catalytic activities comparable with those of mammalian enzyme
Drug Metab. Dispos.
37
302-309
2009
Danio rerio (Q6NY42), Danio rerio, Danio rerio AB (Q6NY42)
Akhtar, T.A.; McQuinn, R.P.; Naponelli, V.; Gregory, J.F.; Giovannoni, J.J.; Hanson, A.D.
Tomato gamma-glutamylhydrolases: expression, characterization, and evidence for heterodimer formation
Plant Physiol.
148
775-785
2008
Solanum lycopersicum (B2Z9Y3), Solanum lycopersicum (B2Z9Y4), Solanum lycopersicum (B2Z9Y5), Solanum lycopersicum
Castellano, I.; Merlino, A.; Rossi, M.; La Cara, F.
Biochemical and structural properties of gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: An enzyme specialized in hydrolase activity
Biochimie
92
464-474
2010
Geobacillus thermodenitrificans
Pollard, C.; Nitz, M.; Baras, A.; Williams, P.; Moskaluk, C.; Theodorescu, D.
Genoproteomic mining of urothelial cancer suggests {gamma}-glutamyl hydrolase and diazepam-binding inhibitor as putative urinary markers of outcome after chemotherapy
Am. J. Pathol.
175
1824-1830
2009
Homo sapiens
Sadahiro, S.; Suzuki, T.; Maeda, Y.; Tanaka, A.; Ogoshi, K.; Kamijo, A.; Murayama, C.; Tsukioka, S.; Sakamoto, E.; Fukui, Y.; Oka, T.
Molecular determinants of folate levels after leucovorin administration in colorectal cancer
Cancer Chemother. Pharmacol.
65
735-742
2010
Homo sapiens (Q92820), Homo sapiens
Smit, E.F.; Burgers, S.A.; Biesma, B.; Smit, H.J.; Eppinga, P.; Dingemans, A.M.; Joerger, M.; Schellens, J.H.; Vincent, A.; van Zandwijk, N.; Groen, H.J.
Randomized phase II and pharmacogenetic study of pemetrexed compared with pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer
J. Clin. Oncol.
27
2038-2045
2009
Homo sapiens
Organista-Nava, J.; Gomez-Gomez, Y.; Saavedra-Herrera, M.V.; Rivera-Ramirez, A.B.; Teran-Porcayo, M.A.; Alarcon-Romero, L.d.e.l..C.; Illades-Aguiar, B.; Leyva-Vazquez, M.A.
Polymorphisms of the gamma-glutamyl hydrolase gene and risk of relapse to acute lymphoblastic leukemia in Mexico
Leuk. Res.
34
728-732
2010
Homo sapiens
Tsirulnikov, K.; Abuladze, N.; Bragin, A.; Faull, K.; Cascio, D.; Damoiseaux, R.; Schibler, M.J.; Pushkin, A.
Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal
Toxicol. Appl. Pharmacol.
263
303-314
2012
Mus musculus
Kim, S.E.; Cole, P.D.; Cho, R.C.; Ly, A.; Ishiguro, L.; Sohn, K.J.; Croxford, R.; Kamen, B.A.; Kim, Y.I.
gamma-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate
Br. J. Cancer
109
2175-2188
2013
Homo sapiens
Ramos-Parra, P.; Urrea-Lopez, R.; Diaz de la Garza, R.
Folate analysis in complex food matrices: Use of a recombinant Arabidopsis ?-glutamyl hydrolase for folate deglutamylation
Food Res. Int.
54
177-185
2013
Arabidopsis thaliana (O65355)
Kim, S.E.; Hinoue, T.; Kim, M.S.; Sohn, K.J.; Cho, R.C.; Cole, P.D.; Weisenberger, D.J.; Laird, P.W.; Kim, Y.I.
gamma-Glutamyl hydrolase modulation significantly influences global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells
Genes Nutr.
10
444
2015
Homo sapiens
Chuankhayan, P.; Kao, T.T.; Lin, C.C.; Guan, H.H.; Nakagawa, A.; Fu, T.F.; Chen, C.J.
Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase
J. Med. Chem.
56
7625-7635
2013
Danio rerio (Q6NY42)
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