Reference on EC 3.4.19.6 - pyroglutamyl-peptidase II
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
O'Connor, B.; O'Cuinn, G.
Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain
Eur. J. Biochem.
150
47-52
1985
Cavia porcellus
Gallagher, S.P.; O'Connor, B.
A study of a highly specific pyroglutamyl aminopeptidase type-II from the membrane fraction of bovine brain
Int. J. Biochem. Cell Biol.
30
115-133
1998
Bos taurus
Scharfmann, R.; Morgat, J.L.; Aratan-Spire, S.
Presence of a particulate thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase activity in rat liver
Neuroendocrinology
49
442-448
1989
Rattus norvegicus
Bauer, K.; Nowak, P.
Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond
Eur. J. Biochem.
99
239-246
1979
Sus scrofa
Elmore, M.A.; Griffiths, E.C.; O'Connor, B.; O'Cuinn, G.
Further characterization of the substrate specificity of a TRH hydrolyzing pyroglutamate aminopeptidase from guinea pig brain
Neuropeptides
15
31-36
1990
Cavia porcellus
Wilk, S.; Wilk, E.K.
Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme
Neurochem. Int.
15
81-89
1989
Oryctolagus cuniculus
Emerson, C.H.
Primary thyrotropin-releasing hormone-degrading enzymes
Methods Enzymol.
168
365-371
1989
Oryctolagus cuniculus
Bauer, K.; Nowak, P.; Kleinkauf, H.
Specificity of a serum peptidase hydrolyzing thyroliberin at pyroglutamyl-histidine bone
Eur. J. Biochem.
118
173-176
1981
Sus scrofa
Bauer, K.
Purification and characterization of the thyrotropin-releasing-hormone-degrading ectoenzyme
Eur. J. Biochem.
224
387-396
1994
Rattus norvegicus, Sus scrofa
Greaney, A.; Phelan, J.; O'Cuinn, G.
Localization of thyroliberin pyroglutamyl peptidase on synaptosomal-membrane preparations of guinea-pig brain tissue
Biochem. Soc. Trans.
8
423
1980
Cavia porcellus
Kelly, J.A.; Slator, G.R.; Tipton, K.F.; Williams, C.H.; Bauer, K.
Kinetic investigation of the specificity of porcine brain thyrotropin-releasing hormone-degrading ectoenzyme for thyrotropin-releasing hormone-like peptides
J. Biol. Chem.
275
16746-16751
2000
Sus scrofa
Schmitmeier, S.; Thole, H.; Bader, A.; Bauer, K.
Purification and characterization of the thyrotropin-releasing hormone (TRH)-degrading serum enzyme and its identification as a product of liver origin
Eur. J. Biochem.
269
1278-1286
2002
Bos taurus, Rattus norvegicus, Sus scrofa
Papadopoulos, T.; Heuer, H.; Bauer, K.
Analysis of the thyrotropin-releasing hormone-degrading ectoenzyme by site-directed mutagenesis of cysteine residues. Cys68 is involved in disulfide-linked dimerization
Eur. J. Biochem.
267
2617-2623
2000
Rattus norvegicus
Pascual, I.; Gil-Parrado, S.; Cisneros, M.; Joseph-Bravo, P.; Diaz, J.; Possani, L.D.; Charli, J.L.; Chavez, M.
Purification of a specific inhibitor of pyroglutamyl aminopeptidase II from the marine annelide Hermodice carunculata. in vivo effects in rodent brain
Int. J. Biochem. Cell Biol.
36
138-152
2004
Mus musculus, Rattus norvegicus
Kelly, J.A.; Scalabrino, G.A.; Slator, G.R.; Cullen, A.A.; Gilmer, J.F.; Lloyd, D.G.; Bennett, G.W.; Bauer, K.; Tipton, K.F.; Williams, C.H.
Structure-activity studies with high-affinity inhibitors of pyroglutamyl-peptidase II
Biochem. J.
389
569-576
2005
Rattus norvegicus
Garcia-Lopez, M.J.; Martinez-Martos, J.M.; Mayas, M.D.; Carrera, M.P.; Ramirez-Exposito, M.J.
Effects of orchidectomy and testosterone replacement on mouse pyrrolidone carboxypeptidase activity in the HPA axis
Horm. Metab. Res.
36
131-135
2004
Mus musculus
Chavez-Gutierrez, L.; Matta-Camacho, E.; Osuna, J.; Horjales, E.; Joseph-Bravo, P.; Maigret, B.; Charli, J.L.
Homology modeling and site-directed mutagenesis of pyroglutamyl peptidase II. Insights into omega-versus aminopeptidase specificity in the M1 family
J. Biol. Chem.
281
18581-18590
2006
Rattus norvegicus
Chavez-Gutierrez, L.; Bourdais, J.; Aranda, G.; Vargas, M.A.; Matta-Camacho, E.; Ducancel, F.; Segovia, L.; Joseph-Bravo, P.; Charli, J.L.
A truncated isoform of pyroglutamyl aminopeptidase II produced by exon extension has dominant-negative activity
J. Neurochem.
92
807-817
2005
Rattus norvegicus
de Gortari, P.; Uribe, R.M.; Garcia-Vazquez, A.; Aguilar-Valles, A.; Martinez, A.; Valdes, A.; Charli, J.L.; Fernandez-Guardiola, A.; Joseph-Bravo, P.
Amygdala kindling differentially regulates the expression of the elements involved in TRH transmission
Neurochem. Int.
48
31-42
2006
Rattus norvegicus
de Gortari, P.; Vargas, M.A.; Martinez, A.; Garcia-Vazquez, A.I.; Uribe, R.M.; Chavez-Gutierrez, L.; Magdaleno, V.; Boileau, G.; Charli, J.L.; Joseph-Bravo, P.
Stage-specific modulation of neprilysin and aminopeptidase N in the limbic system during kindling progression
J. Mol. Neurosci.
33
252-261
2007
Rattus norvegicus
Aguilar-Valles, A.; Sanchez, E.; de Gortari, P.; Garcia-Vazquez, A.I.; Ramirez-Amaya, V.; Bermudez-Rattoni, F.; Joseph-Bravo, P.
The expression of TRH, its receptors and degrading enzyme is differentially modulated in the rat limbic system during training in the Morris water maze
Neurochem. Int.
50
404-417
2007
Rattus norvegicus
Scalabrino, G.A.; Hogan, N.; OBoyle, K.M.; Slator, G.R.; Gregg, D.J.; Fitchett, C.M.; Draper, S.M.; Bennett, G.W.; Hinkle, P.M.; Bauer, K.; Williams, C.H.; Tipton, K.F.; Kelly, J.A.
Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone
Neuropharmacology
52
1472-1481
2007
Rattus norvegicus
Gutierrez-Mariscal, M.; de Gortari, P.; Lopez-Rubalcava, C.; Martinez, A.; Joseph-Bravo, P.
Analysis of the anxiolytic-like effect of TRH and the response of amygdalar TRHergic neurons in anxiety
Psychoneuroendocrinology
33
198-213
2008
Rattus norvegicus
Sanchez, E.; Vargas, M.A.; Singru, P.S.; Pascual, I.; Romero, F.; Fekete, C.; Charli, J.L.; Lechan, R.M.
Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence
Endocrinology
150
2283-2291
2009
Rattus norvegicus
Matziari, M.; Bauer, K.; Dive, V.; Yiotakis, A.
Synthesis of the phosphinic analogue of thyrotropin releasing hormone
J. Org. Chem.
73
8591-8593
2008
Mammalia
Rodriguez-Molina, V.; Vargas, M.A.; Joseph-Bravo, P.; Charli, J.L.
NMDA receptor up-regulates pyroglutamyl peptidase II activity in the rat hippocampus
Neurosci. Lett.
449
211-214
2009
Rattus norvegicus
Cruz, R.; Vargas, M.A.; Uribe, R.M.; Pascual, I.; Lazcano, I.; Yiotakis, A.; Matziari, M.; Joseph-Bravo, P.; Charli, J.L.
Anterior pituitary pyroglutamyl peptidase II activity controls TRH-induced prolactin release
Peptides
29
1953-1964
2008
Rattus norvegicus
Rodriguez-Molina, V.; Patino, J.; Vargas, Y.; Sanchez-Jaramillo, E.; Joseph-Bravo, P.; Charli, J.L.
TRH regulates action potential shape in cerebral cortex pyramidal neurons
Brain Res.
1571
1-11
2014
Rattus norvegicus
Alvarez-Salas, E.; Aceves, C.; Anguiano, B.; Uribe, R.M.; Garcia-Luna, C.; Sanchez, E.; de Gortari, P.
Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II
Endocrinology
153
4067-4076
2012
Rattus norvegicus
Lazcano, I.; Uribe, R.M.; Martinez-Chavez, E.; Vargas, M.A.; Matziari, M.; Joseph-Bravo, P.; Charli, J.L.
Pyroglutamyl peptidase II inhibition enhances the analeptic effect of thyrotropin-releasing hormone in the rat medial septum
J. Pharmacol. Exp. Ther.
342
222-231
2012
Rattus norvegicus (Q10836), Rattus norvegicus
Ramirez-Exposito, M.; Martinez-Martos, J.
High cholesterol intake modifies pyroglutamyl aminopeptidase activity in serum and different tissues of male and female mice
Curr. Top. Pept. Protein Res.
18
103-108
2017
Mus musculus (Q9UKU6)
-
Lazcano, I.; Cabral, A.; Uribe, R.M.; Jaimes-Hoy, L.; Perello, M.; Joseph-Bravo, P.; Sanchez-Jaramillo, E.; Charli, J.L.
Fasting enhances pyroglutamyl peptidase II activity in Tanycytes of the mediobasal hypothalamus of male adult rats
Endocrinology
156
2713-2723
2015
Rattus norvegicus (Q10836)
Alvarez-Salas, E.; Alcantara-Alonso, V.; Matamoros-Trejo, G.; Vargas, M.A.; Morales-Mulia, M.; de Gortari, P.
Mediobasal hypothalamic and adenohypophyseal TRH-degrading enzyme (PPII) is down-regulated by zinc deficiency
Int. J. Dev. Neurosci.
46
115-124
2015
Rattus norvegicus (Q10836)
html completed
