Reference on EC 3.4.17.23 - angiotensin-converting enzyme 2
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yan, Z.H.; Ren, K.J.; Wang, Y.; Chen, S.; Brock, T.A.; Rege, A.A.
Development of intramolecularly quenched fluorescent peptides as substrates of angiotensin-converting enzyme 2
Anal. Biochem.
312
141-147
2003
Homo sapiens (Q9BYF1), Homo sapiens
Guy, J.L.; Jackson, R.M.; Acharya, K.R.; Sturrock, E.D.; Hooper, N.M.; Turner, A.J.
Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence
Biochemistry
42
13185-13192
2003
Homo sapiens (Q9BYF1)
Donoghue, M.; Hsieh, F.; Baronas, E.; Godbout, K.; Gosselin, M.; Stagliano, N.; Donovan, M.; Woolf, B.; Robison, K.; Jeyaseelan, R.; Breitbart, R.E.; Acton, S.
A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
Circ. Res.
87
E1-9
2000
Homo sapiens (Q9BYF1), Homo sapiens
Zisman, L.S.; Keller, R.S.; Weaver, B.; Lin, Q.; Speth, R.; Bristow, M.R.; Canver, C.C.
Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme homologue ACE2
Circulation
108
1707-1712
2003
Homo sapiens (Q9BYF1), Homo sapiens
Tikellis, C.; Johnston, C.I.; Forbes, J.M.; Burns, W.C.; Burrell, L.M.; Risvanis, J.; Cooper, M.E.
Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy
Hypertension
41
392-397
2003
Rattus norvegicus
Dales, N.A.; Gould, A.E.; Brown, J.A.; Calderwood, E.F.; Guan, B.; Minor, C.A.; Gavin, J.M.; Hales, P.; Kaushik, V.K.; Stewart, M.; Tummino, P.J.; Vickers, C.S.; Ocain, T.D.; Patane, M.A.
Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors
J. Am. Chem. Soc.
124
11852-11853
2002
Homo sapiens (Q9BYF1)
Tipnis, S.R.; Hooper, N.M.; Hyde, R.J.; Christie, G.; Karran, E.; Turner, A.J.
A humen homolog of angiotensin converting enzyme - cloning and functional expression as a captopril-insensitive carboxypeptidase
J. Biol. Chem.
275
33238-33243
2000
Homo sapiens (Q9BYF1)
Vickers, C.; Hales, P.; Kaushik, V.; Dick, L.; Gavin, J.; Tang, J.; Godbout, K.; Parsons, T.; Baronas, E.; Hsieh, F.; Acton, S.; Patane, M.; Nichols, A.; Tummino, P.
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase
J. Biol. Chem.
277
14838-14843
2002
Homo sapiens (Q9BYF1), Homo sapiens
Huang, L.; Sexton, D.J.; Skogerson, K.; Devlin, M.; Smith, R.; Sanyal, I.; Parry, T.; Kent, R.; Enright, J.; Wu, Q.L.; Conley, G.; DeOliveira, D.; Morganelli, L.; Ducar, M.; Wescott, C.R.; Ladner, R.C.
Novel peptide inhibitors of angiotensin-converting enzyme 2
J. Biol. Chem.
278
15532-15540
2003
Homo sapiens (Q9BYF1), Homo sapiens
Stoesser, G.; Baker, W.; van den Broek, A.; Garcia-Pastor, M.; Kanz, C.; Kulikova, T.; Leinonen, R.; Lin Q.; Lombard, V.; Lopez, R.; Mancuso, R.; Nardone, F.; Stoehr, P.; Tuli, M.A.; Tzouvara, K.; Vaughan, R.
The EMBL Nucleotide Sequence Database: major new developments
Nucleic Acids Res.
31
17-22
2003
Rhipicephalus microplus (Q17248)
Benson, D.A.; Karsch-Mizrachi, I.; Lipman, D.J.; Ostell, J.; Wheeler, D.L.
GenBank: update
Nucleic Acids Res.
32
D23-D26
2004
Homo sapiens (Q9BYF1)
Dantas, A.P.; Sandberg, K.
Regulation of ACE2 and ANG-(1-7) in the aorta: New insights into the renin-angiotensin system in the control of vascular function
Am. J. Physiol.
289
H980-H981
2005
Rattus norvegicus
Gallagher, P.E.; Chappell, M.C.; Ferrario, C.M.; Tallant, E.A.
Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes
Am. J. Physiol.
290
C420-C426
2006
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Li, N.; Zimpelmann, J.; Cheng, K.; Wilkins, J.A.; Burns, K.D.
The role of angiotensin converting enzyme 2 in the generation of angiotensin 1-7 by rat proximal tubules
Am. J. Physiol. Renal Physiol.
288
F353-F362
2005
Rattus norvegicus
Rice, G.I.; Thomas, D.A.; Grant, P.J.; Turner, A.J.; Hooper, N.M.
Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism
Biochem. J.
383
45-51
2004
Homo sapiens
Warner, F.J.; Smith, A.I.; Hooper, N.M.; Turner, A.J.
Angiotensin-converting enzyme-2: a molecular and cellular perspective
Cell. Mol. Life Sci.
61
2704-2713
2004
Homo sapiens
Danilczyk, U.; Eriksson, U.; Oudit, G.Y.; Penninger, J.M.
Physiological roles of angiotensin-converting enzyme 2
Cell. Mol. Life Sci.
61
2714-2719
2004
Homo sapiens
Kuhn, J.H.; Li, W.; Choe, H.; Farzan, M.
Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus
Cell. Mol. Life Sci.
61
2738-2743
2004
Chlorocebus aethiops
Ferrario, C.M.; Jessup, J.; Chappell, M.C.; Averill, D.B.; Brosnihan, K.B.; Tallant, E.A.; Diz, D.I.; Gallagher, P.E.
Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2
Circulation
111
2605-2610
2005
Rattus norvegicus
Tikellis, C.; Johnston, C.I.; Forbes, J.M.; Burns, W.C.; Thomas, M.C.; Lew, R.A.; Yarski, M.; Smith, A.I.; Cooper, M.E.
Identification of angiotensin converting enzyme 2 in the rodent retina
Curr. Eye Res.
29
419-427
2004
Rattus norvegicus
Kuba, K.; Imai, Y.; Penninger, J.M.
Angiotensin-converting enzyme 2 in lung diseases
Curr. Opin. Pharmacol.
6
271-276
2006
Homo sapiens
Douglas, G.C.; OBryan, M.K.; Hedger, M.P.; Lee, D.K.; Yarski, M.A.; Smith, A.I.; Lew, R.A.
The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis
Endocrinology
145
4703-4711
2004
Rattus norvegicus, Homo sapiens (Q9BYF1)
Katovich, M.J.; Grobe, J.L.; Huentelman, M.; Raizada, M.K.
Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension
Exp. Physiol.
90
299-305
2005
Rattus norvegicus
Guy, J.L.; Jackson, R.M.; Jensen, H.A.; Hooper, N.M.; Turner, A.J.
Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis
FEBS J.
272
3512-3520
2005
Homo sapiens
Riviere, G.; Michaud, A.; Breton, C.; VanCamp, G.; Laborie, C.; Enache, M.; Lesage, J.; Deloof, S.; Corvol, P.; Vieau, D.
Angiotensin-converting enzyme 2 (ACE2) and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat
Hypertension
46
1169-1174
2005
Rattus norvegicus
Elased, K.M.; Cunha, T.S.; Gurley, S.B.; Coffman, T.M.; Morris, M.
New mass spectrometric assay for angiotensin-converting enzyme 2 activity
Hypertension
47
1010-1017
2006
Homo sapiens, Mus musculus
Ferrario, C.M.
Angiotensin-converting enzyme 2 and angiotensin-(1-7): an evolving story in cardiovascular regulation
Hypertension
47
515-521
2006
Rattus norvegicus
Rice, G.I.; Jones, A.L.; Grant, P.J.; Carter, A.M.; Turner, A.J.; Hooper, N.M.
Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study
Hypertension
48
914-920
2006
Homo sapiens
Lew, R.A.; Warner, F.J.; Hanchapola, I.; Smith, A.I.
Characterization of angiotensin converting enzyme-2 (ACE2) in human urine
Int. J. Pept. Res. Ther.
12
283-289
2006
Homo sapiens
Warner, F.J.; Lew, R.A.; Smith, A.I.; Lambert, D.W.; Hooper, N.M.; Turner, A.J.
Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells
J. Biol. Chem.
280
39353-39362
2005
Homo sapiens
Campbell, D.J.; Zeitz, C.J.; Esler, M.D.; Horowitz, J.D.
Evidence against a major role for angiotensin converting enzyme-related carboxypeptidase (ACE2) in angiotensin peptide metabolism in the human coronary circulation
J. Hypertens.
22
1971-1976
2004
Homo sapiens
To, K.F.; Lo, A.W.
Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2)
J. Pathol.
203
740-743
2004
Homo sapiens
Kuba, K.; Imai, Y.; Rao, S.; Gao, H.; Guo, F.; Guan, B.; Huan, Y.; Yang, P.; Zhang, Y.; Deng, W.; Bao, L.; Zhang, B.; Liu, G.; Wang, Z.; Chappell, M.; Liu, Y.; Zheng, D.; Leibbrandt, A.; Wada, T.; Slutsky, A.S.; Liu, D.; Qin, C.; Jiang, C.; Penninger, J.M.
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury
Nat. Med.
11
875-879
2005
Mus musculus
Imai, Y.; Kuba, K.; Rao, S.; Huan, Y.; Guo, F.; Guan, B.; Yang, P.; Sarao, R.; Wada, T.; Leong-Poi, H.; Crackower, M.A.; Fukamizu, A.; Hui, C.C.; Hein, L.; Uhlig, S.; Slutsky, A.S.; Jiang, C.; Penninger, J.M.
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Nature
436
112-116
2005
Mus musculus
Valdes, G.; Neves, L.A.; Anton, L.; Corthorn, J.; Chacon, C.; Germain, A.M.; Merrill, D.C.; Ferrario, C.M.; Sarao, R.; Penninger, J.; Brosnihan, K.B.
Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies
Placenta
27
200-207
2006
Homo sapiens
Huentelman, M.J.; Zubcevic, J.; Katovich, M.J.; Raizada, M.K.
Cloning and characterization of a secreted form of angiotensin-converting enzyme 2
Regul. Pept.
122
61-67
2004
Homo sapiens
Trask, A.J.; Averill, D.B.; Ganten, D.; Chappell, M.C.; Ferrario, C.M.
Primary role of angiotensin-converting enzyme-2 in cardiac production of angiotensin-(1-7) in transgenic Ren-2 hypertensive rats
Am. J. Physiol. Heart Circ. Physiol.
292
H3019-H3024
2007
Rattus norvegicus
Li, X.; Molina-Molina, M.; Abdul-Hafez, A.; Uhal, V.; Xaubet, A.; Uhal, B.D.
Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis
Am. J. Physiol. Lung Cell Mol. Physiol.
295
L178-185
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Joyner, J.; Neves, L.A.; Granger, J.P.; Alexander, B.T.; Merrill, D.C.; Chappell, M.C.; Ferrario, C.M.; Davis, W.P.; Brosnihan, K.B.
Temporal-spatial expression of ANG-(1-7) and angiotensin-converting enzyme 2 in the kidney of normal and hypertensive pregnant rats
Am. J. Physiol. Regul. Integr. Comp. Physiol.
293
R169-R177
2007
Rattus norvegicus
Ho, T.Y.; Wu, S.L.; Chen, J.C.; Li, C.C.; Hsiang, C.Y.
Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction
Antiviral Res.
74
92-101
2007
Homo sapiens
Lambert, D.W.; Hooper, N.M.; Turner, A.J.
Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system
Biochem. Pharmacol.
75
781-786
2008
Homo sapiens, Mus musculus
Deaton, D.N.; Gao, E.N.; Graham, K.P.; Gross, J.W.; Miller, A.B.; Strelow, J.M.
Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite
Bioorg. Med. Chem. Lett.
18
732-737
2008
Homo sapiens (Q9BYF1)
Zhong, J.C.; Yu, X.Y.; Lin, Q.X.; Li, X.H.; Huang, X.Z.; Xiao, D.Z.; Lin, S.G.
Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression
Br. J. Pharmacol.
153
66-74
2008
Homo sapiens (Q9BYF1), Homo sapiens
Keidar, S.; Kaplan, M.; Gamliel-Lazarovich, A.
ACE2 of the heart: From angiotensin I to angiotensin (1-7)
Cardiovasc. Res.
73
463-469
2007
Mus musculus, Rattus norvegicus
Imai, Y.; Kuba, K.; Penninger, J.M.
Angiotensin-converting enzyme 2 in acute respiratory distress syndrome
Cell. Mol. Life Sci.
64
2006-2012
2007
Mus musculus
Koitka, A.; Cooper, M.E.; Thomas, M.C.; Tikellis, C.
Angiotensin converting enzyme 2 in the kidney
Clin. Exp. Pharmacol. Physiol.
35
420-425
2008
Rattus norvegicus
Imai, Y.; Kuba, K.; Penninger, J.M.
The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice
Exp. Physiol.
93
543-548
2008
Mus musculus
Zulli, A.; Rai, S.; Buxton, B.F.; Burrell, L.M.; Hare, D.L.
Co-localization of angiotensin-converting enzyme 2-, octomer-4- and CD34-positive cells in rabbit atherosclerotic plaques
Exp. Physiol.
93
564-569
2008
Oryctolagus cuniculus
Guy, J.L.; Lambert, D.W.; Turner, A.J.; Porter, K.E.
Functional angiotensin-converting enzyme 2 is expressed in human cardiac myofibroblasts
Exp. Physiol.
93
579-588
2008
Homo sapiens
Garabelli, P.J.; Modrall, J.G.; Penninger, J.M.; Ferrario, C.M.; Chappell, M.C.
Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart
Exp. Physiol.
93
613-621
2008
Mus musculus
Elased, K.M.; Cunha, T.S.; Marcondes, F.K.; Morris, M.
Brain angiotensin-converting enzymes: role of angiotensin-converting enzyme 2 in processing angiotensin II in mice
Exp. Physiol.
93
665-675
2008
Mus musculus
Lew, R.A.; Warner, F.J.; Hanchapola, I.; Yarski, M.A.; Manohar, J.; Burrell, L.M.; Smith, A.I.
Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor
Exp. Physiol.
93
685-693
2008
Homo sapiens
Lambert, D.W.; Clarke, N.E.; Hooper, N.M.; Turner, A.J.
Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain
FEBS Lett.
582
385-390
2008
Homo sapiens
Yamazato, M.; Yamazato, Y.; Sun, C.; Diez-Freire, C.; Raizada, M.K.
Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats
Hypertension
49
926-931
2007
Rattus norvegicus
Der Sarkissian, S.; Grobe, J.L.; Yuan, L.; Narielwala, D.R.; Walter, G.A.; Katovich, M.J.; Raizada, M.K.
Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology
Hypertension
51
712-718
2008
Rattus norvegicus
Ye, M.; Wysocki, J.; William, J.; Soler, M.J.; Cokic, I.; Batlle, D.
Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: implications for albuminuria in diabetes
J. Am. Soc. Nephrol.
17
3067-3075
2006
Mus musculus
Wiener, R.S.; Cao, Y.X.; Hinds, A.; Ramirez, M.I.; Williams, M.C.
Angiotensin converting enzyme 2 is primarily epithelial and is developmentally regulated in the mouse lung
J. Cell. Biochem.
101
1278-1291
2007
Mus musculus (Q8R0I0), Mus musculus
Rella, M.; Rushworth, C.A.; Guy, J.L.; Turner, A.J.; Langer, T.; Jackson, R.M.
Structure-based pharmacophore design and virtual screening for novel angiotensin converting enzyme 2 inhibitors
J. Chem. Inf. Model.
46
708-716
2006
Homo sapiens
Herath, C.B.; Warner, F.J.; Lubel, J.S.; Dean, R.G.; Jia, Z.; Lew, R.A.; Smith, A.I.; Burrell, L.M.; Angus, P.W.
Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis
J. Hepatol.
47
387-395
2007
Rattus norvegicus
Zulli, A.; Burrell, L.M.; Widdop, R.E.; Black, M.J.; Buxton, B.F.; Hare, D.L.
Immunolocalization of ACE2 and AT2 receptors in rabbit atherosclerotic plaques
J. Histochem. Cytochem.
54
147-150
2006
Oryctolagus cuniculus
Mores, A.; Matziari, M.; Beau, F.; Cuniasse, P.; Yiotakis, A.; Dive, V.
Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2
J. Med. Chem.
51
2216-2226
2008
Homo sapiens (Q9BYF1), Homo sapiens
Fukushi, S.; Mizutani, T.; Sakai, K.; Saijo, M.; Taguchi, F.; Yokoyama, M.; Kurane, I.; Morikawa, S.
Amino acid substitutions in the s2 region enhance severe acute respiratory syndrome coronavirus infectivity in rat angiotensin-converting enzyme 2-expressing cells
J. Virol.
81
10831-10834
2007
Rattus norvegicus
Guo, H.; Guo, A.; Wang, C.; Yan, B.; Lu, H.; Chen, H.
Expression of feline angiotensin converting enzyme 2 and its interaction with SARS-CoV S1 protein
Res. Vet. Sci.
84
494-496
2008
Felis silvestris (Q56H28), Rattus norvegicus (Q5EGZ1), Mus musculus (Q8R0I0), Homo sapiens (Q9BYF1), Homo sapiens
Koka, V.; Huang, X.R.; Chung, A.C.; Wang, W.; Truong, L.D.; Lan, H.Y.
Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway
Am. J. Pathol.
172
1174-1183
2008
Homo sapiens (Q9BYF1)
Herath. C.B.; Lubel, J.S.; Jia, Z.; Velkoska, E.; Casley, D.; Brown, L.; Tikellis, C.; Burrell, L.M.; Angus, P.W.
Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of angiotensin converting enzyme (ACE) and ACE2
Am. J. Physiol. Gastrointest. Liver Physiol.
297
G98-G106
2009
Rattus norvegicus (Q5EGZ1)
Levy, A.; Yagil, Y.; Bursztyn, M.; Barkalifa, R.; Scharf, S.; Yagil, C.
ACE2 expression and activity are enhanced during pregnancy
Am. J. Physiol. Regul. Integr. Comp. Physiol.
295
R1953-R1961
2008
Rattus norvegicus (Q5EGZ1)
Feng, Y.; Yue, X.; Xia, H.; Bindom, S.M.; Hickman, P.J.; Filipeanu, C.M.; Wu, G.; Lazartigues, E.
Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation
Circ. Res.
102
729-736
2008
Mus musculus (Q8R0I0), Mus musculus
Lai, Z.W.; Lew, R.A.; Yarski, M.A.; Mu, F.T.; Andrews, R.K.; Smith, A.I.
The identification of a calmodulin-binding domain within the cytoplasmic tail of angiotensin-converting enzyme-2
Endocrinology
150
2376-2381
2009
Homo sapiens (Q9BYF1)
Rushworth, C.A.; Guy, J.L.; Turner, A.J.
Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis
FEBS J.
275
6033-6042
2008
Homo sapiens (Q9BYF1)
Hernandez Prada, J.A.; Ferreira, A.J.; Katovich, M.J.; Shenoy, V.; Qi, Y.; Santos, R.A.; Castellano, R.K.; Lampkins, A.J.; Gubala, V.; Ostrov, D.A.; Raizada, M.K.
Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents
Hypertension
51
1312-1317
2008
Rattus norvegicus (Q5EGZ1)
Huang, Q.; Xie, Q.; Shi, C.C.; Xiang, X.G.; Lin, L.Y.; Gong, B.D.; Zhao, G.D.; Wang, H.; Jia, NN.
Expression of angiotensin-converting enzyme 2 in CCL4-induced rat liver fibrosis
Int. J. Mol. Med.
23
717-723
2009
Rattus norvegicus (Q5EGZ1)
Towler, P.; Staker, B.; Prasad, S.G.; Menon, S.; Tang, J.; Parsons,T.; Ryan, D.; Fisher, M.; Williams, D.; Dales, N.A.; Patane, M.A.; Pantoliano, M.W.
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis
J. Biol. Chem.
279
17996-18007
2004
Homo sapiens (Q9BYF1)
Ferreira. A.J.; Raizada, M.K.
Are we poised to target ACE2 for the next generation of antihypertensives?
J. Mol. Med.
86
685-690
2008
Homo sapiens (Q9BYF1)
Xia, H.; Lazartigues, E.
Angiotensin-converting enzyme 2 in the brain: properties and future directions
J. Neurochem.
107
1482-1494
2008
Rattus norvegicus (Q5EGZ1), Mus musculus (Q8R0I0), Homo sapiens (Q9BYF1)
Luhtala, S.; Vaajanen, A.; Oksala, O.; Valjakka, J.; Vapaatalo, H.
Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues
J. Ocul. Pharmacol. Ther.
25
23-28
2009
Sus scrofa
Sluimer, J.C.; Gasc, J.M.; Hamming, I.; van Goor, H.; Michaud, A.; van den Akker, L.H.; Juetten, B.; Cleutjens, J.; Bijnens, A.P.; Corvol, P.; Daemen, M.J.; Heeneman, S.
Angiotensin-converting enzyme 2 (ACE2) expression and activity in human carotid atherosclerotic lesions
J. Pathol.
215
273-279
2008
Homo sapiens (Q9BYF1), Homo sapiens
Bindom, S.M.; Lazartigues, E.
The sweeter side of ACE2: physiological evidence for a role in diabetes
Mol. Cell. Endocrinol.
302
193-202
2009
Rattus norvegicus (Q5EGZ1), Homo sapiens (Q9BYF1)
Oudit, G.Y.; Imai, Y.; Kuba, K.; Scholey, J.W.; Penninger, J.M.
The role of ACE2 in pulmonary diseases - relevance for the nephrologist.
Nephrol. Dial. Transplant.
24
1362-1365
2009
Homo sapiens (Q9BYF1)
Vaz-Silva, J.; Carneiro, M.M.; Ferreira, M.C.; Pinheiro, S.V.; Silva, D.A.; Silva-Filho, A.L.; Witz, C.A.; Reis, A.M.; Santos, R.A.; Reis, F.M.
The vasoactive peptide angiotensin-(1-7), its receptor Mas and the angiotensin-converting enzyme type 2 are expressed in the human endometrium
Reprod. Sci.
16
247-256
2009
Homo sapiens (Q9BYF1), Homo sapiens
Zhou, L.; Zhang, R.; Yao, W.; Wang, J.; Qian, A.; Qiao, M.; Zhang, Y.; Yuan, Y.
Decreased expression of Angiotensin-converting enzyme 2 in pancreatic ductal adenocarcinoma is associated with tumor progression
Tohoku J. Exp. Med.
217
123-131
2009
Homo sapiens (Q9BYF1), Homo sapiens
Clayton, D.; Hanchapola, I.; Perlmutter, P.; Smith, A.I.; Aguilar, M.I.
The active site specificity of angiotensin II converting enzyme 2 investigated through single and multiple residue changes and beta-amino acid substrate analogs
Adv. Exp. Med. Biol.
611
559-560
2009
Homo sapiens
Trask, A.J.; Groban, L.; Westwood, B.M.; Varagic, J.; Ganten, D.; Gallagher, P.E.; Chappell, M.C.; Ferrario, C.M.
Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats
Am. J. Hypertens.
23
687-693
2010
Rattus norvegicus
Iwata, M.; Silva Enciso, J.E.; Greenberg, B.H.
Selective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor alpha-converting enzyme
Am. J. Physiol. Cell Physiol.
297
C1318-C1329
2009
Cricetulus griseus, Mus musculus
Jia, H.P.; Look, D.C.; Tan, P.; Shi, L.; Hickey, M.; Gakhar, L.; Chappell, M.C.; Wohlford-Lenane, C.; McCray, P.B.
Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia
Am. J. Physiol. Lung Cell Mol. Physiol.
297
L84-L96
2009
Homo sapiens (Q9BYF1), Homo sapiens
Takahashi, Y.; Haga, S.; Ishizaka, Y.; Mimori, A.
Autoantibodies to angiotensin-converting enzyme 2 in patients with connective tissue diseases
Arthritis Res. Ther.
12
R85
2010
Homo sapiens
Kassiri, Z.; Zhong, J.; Guo, D.; Basu, R.; Wang, X.; Liu, P.P.; Scholey, J.W.; Penninger, J.M.; Oudit, G.Y.
Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction
Circ. Heart Fail.
2
446-455
2009
Mus musculus
Huang, M.L.; Li, X.; Meng, Y.; Xiao, B.; Ma, Q.; Ying, S.S.; Wu, P.S.; Zhang, Z.S.
Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors
Clin. Exp. Pharmacol. Physiol.
37
e1-e6
2010
Rattus norvegicus
Zhao, Y.; Yin, H.Q.; Yu, Q.T.; Qiao, Y.; Dai, H.Y.; Zhang, M.X.; Zhang, L.; Liu, Y.F.; Wang, L.C.; Liu, D.S.; Deng, B.P.; Zhang, Y.H.; Pang, C.M.; Song, H.D.; Qu, X.; Jiang, H.; Liu, C.X.; Lu, X.T.; Liu, B.; Gao, F.; Dong, B.
ACE2 overexpression improves left ventricular remodeling and function in rats with myocardial infarction
Hum. Gene Ther.
21
1545-1554
2010
Rattus norvegicus
Xia, H.; Feng, Y.; Obr, T.D.; Hickman, P.J.; Lazartigues, E.
Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice
Hypertension
53
210-216
2009
Mus musculus
Masson, R.; Nicklin, S.A.; Craig, M.A.; McBride, M.; Gilday, K.; Gregorevic, P.; Allen, J.M.; Chamberlain, J.S.; Smith, G.; Graham, D.; Dominiczak, A.F.; Napoli, C.; Baker, A.H.
Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2
Hypertension
53
694-700
2009
Oryctolagus cuniculus, Rattus norvegicus
Stewart, J.M.; Ocon, A.J.; Clarke, D.; Taneja, I.; Medow, M.S.
Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome
Hypertension
53
767-774
2009
Homo sapiens
Yoshikawa, N.; Yoshikawa, T.; Hill, T.; Huang, C.; Watts, D.M.; Makino, S.; Milligan, G.; Chan, T.; Peters, C.J.; Tseng, C.T.
Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2
J. Virol.
83
5451-5465
2009
Homo sapiens
Fraga-Silva, R.A.; Sorg, B.S.; Wankhede, M.; Dedeugd, C.; Jun, J.Y.; Baker, M.B.; Li, Y.; Castellano, R.K.; Katovich, M.J.; Raizada, M.K.; Ferreira, A.J.
ACE2 activation promotes antithrombotic activity
Mol. Med.
16
210-215
2010
Mus musculus, Rattus norvegicus
Feng, Y.; Wan, H.; Liu, J.; Zhang, R.; Ma, Q.; Han, B.; Xiang, Y.; Che, J.; Cao, H.; Fei, X.; Qiu, W.
The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer
Oncol. Rep.
23
941-948
2010
Homo sapiens
Lin, C.S.; Pan, C.H.; Wen, C.H.; Yang, T.H.; Kuan, T.C.
Regulation of angiotensin converting enzyme II by angiotensin peptides in human cardiofibroblasts
Peptides
31
1334-1340
2010
Homo sapiens (Q9BYF1), Homo sapiens
Coelho, M.S.; Lopes, K.L.; Freitas, R.d.e.A.; de Oliveira-Sales, E.B.; Bergasmaschi, C.T.; Campos, R.R.; Casarini, D.E.; Carmona, A.K.; Araujo, M.d.a..S.; Heimann, J.C.; Dolnikoff, M.S.
High sucrose intake in rats is associated with increased ACE2 and angiotensin-(1-7) levels in the adipose tissue
Regul. Pept.
162
61-67
2010
Rattus norvegicus
Han, S.X.; He, G.M.; Wang, T.; Chen, L.; Ning, Y.Y.; Luo, F.; An, J.; Yang, T.; Dong, J.J.; Liao, Z.L.; Xu, D.; Wen, F.Q.
Losartan attenuates chronic cigarette smoke exposure-induced pulmonary arterial hypertension in rats: possible involvement of angiotensin-converting enzyme-2
Toxicol. Appl. Pharmacol.
245
100-107
2010
Rattus norvegicus
Cohen-Segev, R.; Francis, B.; Abu-Saleh, N.; Awad, H.; Lazarovich, A.; Kabala, A.; Aronson, D.; Abassi, Z.
Cardiac and renal distribution of ACE and ACE-2 in rats with heart failure
Acta Histochem.
116
1342-1349
2014
Rattus norvegicus
Lambert, D.W.; Lambert, L.A.; Clarke, N.E.; Hooper, N.M.; Porter, K.E.; Turner, A.J.
Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421
Clin. Sci.
127
243-249
2014
Homo sapiens (Q9BYF1), Homo sapiens
Lu, C.L.; Wang, Y.; Yuan, L.; Li, Y.; Li, X.Y.
The angiotensin-converting enzyme 2/angiotensin (1-7)/Mas axis protects the function of pancreatic beta cells by improving the function of islet microvascular endothelial cells
Int. J. Mol. Med.
34
1293-1300
2014
Mus musculus
Liu, S.; Liu, J.; Miura, Y.; Tanabe, C.; Maeda, T.; Terayama, Y.; Turner, A.J.; Zou, K.; Komano, H.
Conversion of Abeta43 to Abeta40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme
J. Neurosci. Res.
92
1178-1186
2014
Homo sapiens, Mus musculus
Zou, Z.; Yan, Y.; Shu, Y.; Gao, R.; Sun, Y.; Li, X.; Ju, X.; Liang, Z.; Liu, Q.; Zhao, Y.; Guo, F.; Bai, T.; Han, Z.; Zhu, J.; Zhou, H.; Huang, F.; Li, C.; Lu, H.; Li, N.; Li, D.; Jin, N.; Penninger, J.M.; Jiang, C.
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections
Nat. Commun.
5
3594
2014
Mus musculus
Feng, Y.; Hans, C.; McIlwain, E.; Varner, K.J.; Lazartigues, E.
Angiotensin-converting enzyme 2 over-expression in the central nervous system reduces angiotensin-II-mediated cardiac hypertrophy
PLoS ONE
7
e48910
2012
Mus musculus
Xiao, F.; Zimpelmann, J.; Agaybi, S.; Gurley, S.B.; Puente, L.; Burns, K.D.
Characterization of angiotensin-converting enzyme 2 ectodomain shedding from mouse proximal tubular cells
PLoS ONE
9
e85958
2014
Mus musculus
Uri, K.; Fagyas, M.; Manyine Siket, I.; Kertesz, A.; Csanadi, Z.; Sandorfi, G.; Clemens, M.; Fedor, R.; Papp, Z.; Edes, I.; Toth, A.; Lizanecz, E.
New perspectives in the renin-angiotensin-aldosterone system (RAAS) IV: circulating ACE2 as a biomarker of systolic dysfunction in human hypertension and heart failure
PLoS ONE
9
e87845
2014
Homo sapiens (Q9BYF1), Homo sapiens
Yang, P.; Gu, H.; Zhao, Z.; Wang, W.; Cao, B.; Lai, C.; Yang, X.; Zhang, L.; Duan, Y.; Zhang, S.; Chen, W.; Zhen, W.; Cai, M.; Penninger, J.M.; Jiang, C.; Wang, X.
Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury
Sci. Rep.
4
7027
2014
Mus musculus
Li, Y.; Cao, Y.; Zeng, Z.; Liang, M.; Xue, Y.; Xi, C.; Zhou, M.; Jiang, W.
Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis prevents lipopolysaccharide-induced apoptosis of pulmonary microvascular endothelial cells by inhibiting JNK/NF-kappaB pathways
Sci. Rep.
5
8209
2015
Rattus norvegicus
Grobe, N.; Weir, N.M.; Leiva, O.; Ong, F.S.; Bernstein, K.E.; Schmaier, A.H.; Morris, M.; Elased, K.M.
Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry
Am. J. Physiol. Cell Physiol.
304
C945-C953
2013
Mus musculus
Meng, Y.; Li, T.; Zhou, G.; Chen, Y.; Yu, C.; Pang, M.; Li, W.; Li, Y.; Zhang, W.; Li, X.
The angiotensin-converting enzyme 2/angiotensin (1-7)/mas axis protects against lung fibroblast migration and lung fibrosis by inhibiting the NOX4-derived ROS-mediated RhoA/Rho kinase pathway
Antioxid. Redox Signal.
22
241-258
2015
Rattus norvegicus (Q5EGZ1)
Fan, J.; Zou, L.; Cui, K.; Woo, K.; Du, H.; Chen, S.; Ling, Z.; Zhang, Q.; Zhang, B.; Lan, X.; Su, L.; Zrenner, B.; Yin, Y.
Atrial overexpression of angiotensin-converting enzyme 2 improves the canine rapid atrial pacing-induced structural and electrical remodeling. Fan, ACE2 improves atrial substrate remodeling
Basic Res. Cardiol.
110
45
2015
Canis lupus familiaris
Chen, Y.; Guo, Y.; Pan, Y.; Zhao, Z.
Structure analysis of the receptor binding of 2019-nCoV
Biochem. Biophys. Res. Commun.
525
135-140
2020
Nipponia nippon (A0A091UR55), Rhinolophus sinicus (E2DHI7), Paguma larvata (Q56NL1), Homo sapiens (Q9BYF1), Callorhinchus milii (XP_007889845.1), Xenopus laevis (XP_018104311.1), Protobothrops mucrosquamatus (XP_029140508.1)
Pandey, A.; Goru, S.K.; Kadakol, A.; Malek, V.; Gaikwad, A.B.
Differential regulation of angiotensin converting enzyme 2 and nuclear factor-kappaB by angiotensin II receptor subtypes in type 2 diabetic kidney
Biochimie
118
71-81
2015
Rattus norvegicus
Cao, Y.; Li, L.; Feng, Z.; Wan, S.; Huang, P.; Sun, X.; Wen, F.; Huang, X.; Ning, G.; Wang, W.
Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations
Cell Discov.
6
11
2020
Homo sapiens (Q9BYF1)
Wang, L.; Wang, Y.; Yang, T.; Guo, Y.; Sun, T.
Angiotensin-converting enzyme 2 attenuates bleomycin-induced lung fibrosis in mice
Cell. Physiol. Biochem.
36
697-711
2015
Mus musculus (Q8R0I0), Mus musculus
Rutkowska-Zapala, M.; Suski, M.; Szatanek, R.; Lenart, M.; Weglarczyk, K.; Olszanecki, R.; Grodzicki, T.; Strach, M.; Gasowski, J.; Siedlar, M.
Human monocyte subsets exhibit divergent angiotensin I-converting activity
Clin. Exp. Immunol.
181
126-132
2015
Homo sapiens (Q9BYF1)
Batlle, D.; Wysocki, J.; Satchell, K.
Soluble angiotensin-converting enzyme 2 a potential approach for coronavirus infection therapy?
Clin. Sci.
134
543-545
2020
Homo sapiens (Q9BYF1)
Cao, X.; Song, L.; Zhang, Y.; Li, Q.; Shi, T.; Yang, F.; Yuan, M.; Xin, Z.; Yang, J.
Angiotensin-converting enzyme 2 inhibits endoplasmic reticulum stress-associated pathway to preserve nonalcoholic fatty liver disease
Diabetes Metab. Res. Rev.
35
e3123
2019
Mus musculus (Q8R0I0), Homo sapiens (Q9BYF1)
Tian, X.; Li, C.; Huang, A.; Xia, S.; Lu, S.; Shi, Z.; Lu, L.; Jiang, S.; Yang, Z.; Wu, Y.; Ying, T.
Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
Emerg. Microbes Infect.
9
382-385
2020
Mus musculus (Q8R0I0)
Clayton, D.; Hanchapola, I.; Thomas, W.; Widdop, R.; Smith, A.; Perlmutter, P.; Aguilar, M.
Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2
Front. Pharmacol.
6
005
2015
Homo sapiens
Wang, W.; McKinnie, S.; Farhan, M.; Paul, M.; McDonald, T.; McLean, B.; Llorens-Cortes, C.; Hazra, S.; Murray, A.; Vederas, J.; Oudit, G.
Angiotensin-converting enzyme 2 metabolizes and partially inactivates pyr-apelin-13 and apelin-17 Physiological effects in the cardiovascular system
Hypertension
68
365-377
2016
Mus musculus (Q8R0I0), Homo sapiens (Q9BYF1), Homo sapiens
Sharma, J.N.; Al-Shoumer, K.; Matar, K.M.; Madathil, N.V.; Al-Moalem, A.
Altered activities of kininase II, an angiotensin converting enzyme, prekallikrein, and nitric oxide in Kuwaiti patients with type 2 diabetes
Int. J. Immunopathol. Pharmacol.
28
240-246
2015
Homo sapiens
Zhang, H.; Penninger, J.; Li, Y.; Zhong, N.; Slutsky, A.
Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor molecular mechanisms and potential therapeutic target
Intensive Care Med.
46
586-590
2020
Homo sapiens (Q9BYF1)
Xiao, F.; Burns, K.D.
Measurement of angiotensin converting enzyme 2 activity in biological fluid (ACE2)
Methods Mol. Biol.
1527
101-115
2017
Mus musculus (Q8R0I0), Mus musculus, Homo sapiens (Q9BYF1), Homo sapiens
Sriramula, S.; Pedersen, K.B.; Xia, H.; Lazartigues, E.
Determining the enzymatic activity of angiotensin-converting enzyme 2 (ACE2) in brain tissue and cerebrospinal fluid using a quenched fluorescent substrate
Methods Mol. Biol.
1527
117-126
2017
Mus musculus (Q8R0I0)
Qiu, Y.; Zhao, Y.B.; Wang, Q.; Li, J.Y.; Zhou, Z.J.; Liao, C.H.; Ge, X.Y.
Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2
Microbes Infect.
22
221-225
2020
Columba livia (A0A2I0MLI2), Sus scrofa (K7GLM4), Felis catus (Q56H28), Paguma larvata (Q56NL1), Mus musculus (Q8R0I0), Homo sapiens (Q9BYF1), Homo sapiens, Rhinolophus sinicus (U5WHY8), Capra hircus (W6CG84), Bos taurus (XP_005228485.1), Bubalus bubalis (XP_006041602.1), Ovis aries (XP_011961657.1), Manis javanica (XP_017505752.1)
Ramchand, J.; Patel, S.; Srivastava, P.; Farouque, O.; Burrell, L.
Elevated plasma angiotensin converting enzyme 2 activity is an independent predictor of major adverse cardiac events in patients with obstructive coronary artery disease
PLoS ONE
13
e0198144
2018
Homo sapiens
Chen, K.; Bi, J.; Su, Y.; Chappell, M.; Rose, J.
Sex-specific changes in renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 gene expression and enzyme activity at birth and over the first year of life
Reprod. Sci.
23
200-210
2016
Ovis aries (W5PSB6), Ovis aries
Cao, X.; Yang, F.; Shi, T.; Yuan, M.; Xin, Z.; Xie, R.; Li, S.; Li, H.; Yang, J.K.
Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis activates Akt signaling to ameliorate hepatic steatosis
Sci. Rep.
6
21592
2016
Mus musculus (Q8R0I0), Homo sapiens (Q9BYF1)
Li, Y.; Zeng, Z.; Cao, Y.; Liu, Y.; Ping, F.; Liang, M.; Xue, Y.; Xi, C.; Zhou, M.; Jiang, W.
Angiotensin-converting enzyme 2 prevents lipopolysaccharide-induced rat acute lung injury via suppressing the ERK1/2 and NF-kappaB signaling pathways
Sci. Rep.
6
27911
2016
Rattus norvegicus (Q5EGZ1)
Li, F.; Li, W.; Farzan, M.; Harrison, S.C.
Structure of SARS coronavirus spike receptor-binding domain complexed with receptor
Science
309
1864-1868
2005
Homo sapiens (Q9BYF1), Homo sapiens
Bojadzic, D.; Alcazar, O.; Chen, J.; Chuang, S.T.; Condor Capcha, J.M.; Shehadeh, L.A.; Buchwald, P.
Small-molecule inhibitors of the coronavirus spike ACE2 protein-protein interaction as blockers of viral attachment and entry for SARS-CoV-2
ACS Infect. Dis.
7
1519-1534
2021
Homo sapiens (Q9BYF1), Homo sapiens
Zhang, Y.; Niu, G.; Flisikowska, T.; Schnieke, A.; Flisikowski, K.
A tissue- and gender-specific regulation of the SARS-CoV-2 receptor ACE2 by p53 in pigs
Biochem. Biophys. Res. Commun.
553
25-29
2021
Sus scrofa (B1PZW5)
Low-Gan, J.; Huang, R.; Kelley, A.; Jenkins, G.W.; McGregor, D.; Smider, V.V.
Diversity of ACE2 and its interaction with SARS-CoV-2 receptor binding domain
Biochem. J.
478
3671-3684
2021
Mustela putorius (Q2WG88), Felis catus (Q56H28), Homo sapiens (Q9BYF1), Rhinolophus sinicus (U5WHY8), Cricetulus griseus (XP_003503283.12), Bos taurus (XP_024843618.1)
Antony, P.; Vijayan, R.
Role of SARS-CoV-2 and ACE2 variations in COVID-19
Biomed. J.
44
235-244
2021
Homo sapiens (Q9BYF1), Homo sapiens
Mehrabadi, M.E.; Hemmati, R.; Tashakor, A.; Homaei, A.; Yousefzadeh, M.; Hemati, K.; Hosseinkhani, S.
Induced dysregulation of ACE2 by SARS-CoV-2 plays a key role in COVID-19 severity
Biomed. Pharmacother.
137
111363
2021
Homo sapiens (Q9BYF1), Homo sapiens
Cao, W.; Dong, C.; Kim, S.; Hou, D.; Tai, W.; Du, L.; Im, W.; Zhang, X.F.
Biomechanical characterization of SARS-CoV-2 spike RBD and human ACE2 protein-protein interaction
Biophys. J.
120
1011-1019
2021
Homo sapiens (Q9BYF1), Homo sapiens
Barros, E.; Casalino, L.; Gaieb, Z.; Dommer, A.; Wang, Y.; Fallon, L.; Raguette, L.; Belfon, K.; Simmerling, C.; Amaro, R.
The flexibility of ACE2 in the context of SARS-CoV-2 infection
Biophys. J.
120
1072-1084
2021
Homo sapiens (Q9BYF1), Homo sapiens
Wang, Y.; Fan, Y.; Huang, Y.; Du, T.; Liu, Z.; Huang, D.; Wang, Y.; Wang, N.; Zhang, P.
TRIM28 regulates SARS-CoV-2 cell entry by targeting ACE2
Cell. Signal.
85
110064
2021
Homo sapiens (Q9BYF1), Homo sapiens
Nesci, S.
SARS-CoV-2 first contact Spike-ACE2 interactions in COVID-19
Chem. Biol. Drug Des.
98
207-211
2021
Homo sapiens (Q9BYF1)
Benitez-Cardoza, C.G.; Vique-Sanchez, J.L.
Identifying compounds that prevent the binding of the SARS-CoV-2 S-protein to ACE2
Comput. Biol. Med.
136
104719
2021
Homo sapiens (Q9BYF1)
Zhou, Z.; Yang, Z.; Ou, J.; Zhang, H.; Zhang, Q.; Dong, M.; Zhang, G.
Temperature dependence of the SARS-CoV-2 affinity to human ACE2 determines COVID-19 progression and clinical outcome
Comput. Struct. Biotechnol. J.
19
161-167
2021
Homo sapiens (Q9BYF1), Homo sapiens
Baby, K.; Maity, S.; Mehta, C.H.; Suresh, A.; Nayak, U.Y.; Nayak, Y.
SARS-CoV-2 entry inhibitors by dual targeting TMPRSS2 and ACE2 An in silico drug repurposing study
Eur. J. Pharmacol.
896
173922
2021
Homo sapiens (Q9BYF1), Homo sapiens
Aleksova, A.; Gagno, G.; Sinagra, G.; Beltrami, A.P.; Janjusevic, M.; Ippolito, G.; Zumla, A.; Fluca, A.L.; Ferro, F.
Effects of SARS-CoV-2 on cardiovascular system the dual role of angiotensin-converting enzyme 2 (ACE2) as the virus receptor and homeostasis regulator-review
Int. J. Mol. Sci.
22
4526
2021
Homo sapiens (Q9BYF1), Homo sapiens
Kiseleva, A.A.; Troisi, E.M.; Hensley, S.E.; Kohli, R.M.; Epstein, J.A.
SARS-CoV-2 spike protein binding selectively accelerates substrate-specific catalytic activity of ACE2
J. Biochem.
170
299-306
2021
Homo sapiens (Q9BYF1), Homo sapiens
Khelfaoui, H.; Harkati, D.; Saleh, B.
Molecular docking, molecular dynamics simulations and reactivity, studies on approved drugs library targeting ACE2 and SARS-CoV-2 binding with ACE2
J. Biomol. Struct. Dyn.
39
7246-7262
2021
Homo sapiens (Q9BYF1)
Choudhury, M.; Dhanabalan, A.; Goswami, N.
Understanding the binding mechanism for potential inhibition of SARS-CoV-2 Mpro and exploring the modes of ACE2 inhibition by hydroxychloroquine
J. Cell. Biochem.
123
347-358
2021
Homo sapiens (Q9BYF1)
Gan, H.H.; Twaddle, A.; Marchand, B.; Gunsalus, K.C.
Structural modeling of the SARS-CoV-2 spike/human ACE2 complex interface can identify high-affinity variants associated with increased transmissibility
J. Mol. Biol.
433
167051
2021
Homo sapiens (Q9BYF1)
Ferrari, M.; Mekkaoui, L.; Ilca, F.T.; Akbar, Z.; Bughda, R.; Lamb, K.; Ward, K.; Parekh, F.; Karattil, R.; Allen, C.; Wu, P.; Baldan, V.; Mattiuzzo, G.; Bentley, E.M.; Takeuchi, Y.; Sillibourne, J.; Datta, P.; Kinna, A.; Pule, M.; Onuoha, S.C.
Characterization of a novel ACE2-based therapeutic with enhanced rather than reduced activity against SARS-CoV-2 variants
J. Virol.
95
e0068521
2021
Homo sapiens (Q9BYF1), Homo sapiens
Liu, X.; Zaid, A.; Freitas, J.R.; McMillan, N.A.; Mahalingam, S.; Taylor, A.
Infectious clones produce SARS-CoV-2 that causes severe pulmonary disease in infected K18-human ACE2 mice
mBio
12
e00819-21
2021
Homo sapiens (Q9BYF1)
Day, C.J.; Bailly, B.; Guillon, P.; Dirr, L.; Jen, F.E.; Spillings, B.L.; Mak, J.; von Itzstein, M.; Haselhorst, T.; Jennings, M.P.
Multidisciplinary approaches identify compounds that bind to human ACE2 or SARS-CoV-2 spike protein as candidates to block SARS-CoV-2-ACE2 receptor interactions
mBio
12
e03681-20
2021
Homo sapiens (Q9BYF1), Homo sapiens
Aboudounya, M.M.; Heads, R.J.
COVID-19 and Toll-like receptor 4 (TLR4) SARS-CoV-2 may bind and activate TLR4 to increase ACE2 expression, facilitating entry and causing hyperinflammation
Mediators Inflamm.
2021
8874339
2021
Homo sapiens (Q9BYF1)
Yang, Y.; Zhang, Y.; Qu, Y.; Zhang, C.; Liu, X.W.; Zhao, M.; Mu, Y.; Li, W.
Key residues of the receptor binding domain in the spike protein of SARS-CoV-2 mediating the interactions with ACE2 a molecular dynamics study
Nanoscale
13
9364-9370
2021
Homo sapiens (Q9BYF1)
Heinzelman, P.; Romero, P.A.
Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein
PLoS ONE
16
e0251585
2021
Homo sapiens (Q9BYF1)
Rawat, P.; Jemimah, S.; Ponnuswamy, P.; Gromiha, M.
Why are ACE2 binding coronavirus strains SARS-CoV/SARS-CoV-2 wild and NL63 mild?
Proteins
89
389-398
2021
Homo sapiens (Q9BYF1), Homo sapiens
Miller, A.; Leach, A.; Thomas, J.; McAndrew, C.; Bentley, E.; Mattiuzzo, G.; John, L.; Mirazimi, A.; Harris, G.; Gamage, N.; Carr, S.; Ali, H.; Van Montfort, R.; Rabbitts, T.
A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection
Sci. Rep.
11
10617
2021
Homo sapiens (Q9BYF1), Homo sapiens
Piplani, S.; Singh, P.K.; Winkler, D.A.; Petrovsky, N.
In silico comparison of SARS-CoV-2 spike protein-ACE2 binding affinities across species and implications for virus origin
Sci. Rep.
11
13063
2021
Mesocricetus auratus (A0A1U7QTA1), Macaca fascicularis (A0A2K5X283), Equus caballus (F6V9L3), Canis lupus familiaris (J9P7Y2), Canis lupus familiaris, Bos taurus (Q2HJI5), Mustela putorius furo (Q2WG88), Mustela putorius furo, Felis catus (Q56H28), Paguma larvata (Q56NL1), Mus musculus (Q8R0I0), Homo sapiens (Q9BYF1), Homo sapiens, Rhinolophus sinicus (U5WHY8), Ophiophagus hannah (V8NIH2), Panthera tigris (XP_007090142), Manis javanica (XP_017505752.1)
Singh, A.; Steinkellner, G.; Koechl, K.; Gruber, K.; Gruber, C.C.
Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2
Sci. Rep.
11
4320
2021
Homo sapiens (Q9BYF1), Homo sapiens
Goc, A.; Niedzwiecki, A.; Rath, M.
Polyunsaturated ?-3 fatty acids inhibit ACE2-controlled SARS-CoV-2 binding and cellular entry
Sci. Rep.
11
5207
2021
Homo sapiens (Q9BYF1)
Ahmad, I.; Pawara, R.; Surana, S.; Patel, H.
The Repurposed ACE2 Inhibitors SARS-CoV-2 entry blockers of covid-19
Top. Curr. Chem.
379
40
2021
Homo sapiens (Q9BYF1)
Ramirez Hernandez, E.; Hernandez-Zimbron, L.F.; Martinez Zuniga, N.; Leal-Garcia, J.J.; Ignacio Hernandez, V.; Ucharima-Corona, L.E.; Perez Campos, E.; Zenteno, E.
The role of the SARS-CoV-2 S-protein glycosylation in the interaction of SARS-CoV-2/ACE2 and immunological responses
Viral Immunol.
34
165-173
2021
Homo sapiens (Q9BYF1), Homo sapiens
Gutierrez-Chamorro, L.; Riveira-Munoz, E.; Barrios, C.; Palau, V.; Nevot, M.; Pedreno-Lopez, S.; Senserrich, J.; Massanella, M.; Clotet, B.; Cabrera, C.; Mitja, O.; Crespo, M.; Pascual, J.; Riera, M.; Ballana, E.
SARS-CoV-2 infection modulates ACE2 function and subsequent inflammatory responses in swabs and plasma of COVID-19 patients
Viruses
13
1715
2021
Homo sapiens (Q9BYF1)
Gutgsell, A.; Gunnarsson, A.; Forssen, P.; Gordon, E.; Fornstedt, T.; Geschwindner, S.
Biosensor-enabled deconvolution of the avidity-induced affinity enhancement for the SARS-CoV-2 spike protein and ACE2 interaction
Anal. Chem.
94
1187-1194
2022
Homo sapiens (Q9BYF1)
Shin, Y.H.; Jeong, K.; Lee, J.; Lee, H.J.; Yim, J.; Kim, J.; Kim, S.; Park, S.B.
Inhibition of ACE2-spike interaction by an ACE2 binder suppresses SARS-CoV-2 entry
Angew. Chem. Int. Ed. Engl.
61
e202115695
2022
Homo sapiens (Q9BYF1)
Huang, Y.; Harris, B.; Minami, S.; Jung, S.; Shah, P.; Nandi, S.; McDonald, K.; Faller, R.
SARS-CoV-2 spike binding to ACE2 is stronger and longer ranged due to glycan interaction
Biophys. J.
121
79-90
2022
Homo sapiens (Q9BYF1)
Lee, J.H.; Lee, Y.; Lee, S.K.; Kim, J.; Lee, C.S.; Kim, N.H.; Kim, H.G.
Versatile role of ACE2-based biosensors for detection of SARS-CoV-2 variants and neutralizing antibodies
Biosens. Bioelectron.
203
114034
2022
Homo sapiens (Q9BYF1)
Han, P.; Li, L.; Liu, S.; Wang, Q.; Zhang, D.; Xu, Z.; Han, P.; Li, X.; Peng, Q.; Su, C.; Huang, B.; Li, D.; Zhang, R.; Tian, M.; Fu, L.; Gao, Y.; Zhao, X.; Liu, K.; Qi, J.; Gao, G.F.; Wang, P.
Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2
Cell
185
630-640.e10
2022
Homo sapiens (Q9BYF1)
Cecon, E.; Burridge, M.; Cao, L.; Carter, L.; Ravichandran, R.; Dam, J.; Jockers, R.
SARS-COV-2 spike binding to ACE2 in living cells monitored by TR-FRET
Cell Chem. Biol.
29
74-83
2022
Homo sapiens (Q9BYF1)
Wang, Z.; Lv, J.; Yu, P.; Qu, Y.; Zhou, Y.; Zhou, L.; Zhu, Q.; Li, S.; Song, J.; Deng, W.; Gao, R.; Liu, Y.; Liu, J.; Tong, W.M.; Qin, C.; Huang, B.
SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages
Cell. Mol. Immunol.
19
210-221
2022
Homo sapiens (Q9BYF1)
Zhang, Y.N.; Zhang, Y.; Su, S.; Zhu, H.Y.; Xu, W.; Wang, L.; Wu, M.; Chen, K.; Yu, F.Q.; Xi, T.K.; Zhou, Q.; Xie, Y.H.; Qin, X.; Ge, H.; Lu, L.; Qing, J.; Fang, G.M.
Neutralizing SARS-CoV-2 by dimeric side chain-to-side chain cross-linked ACE2 peptide mimetics
Chem. Commun. (Camb.)
58
1804-1807
2022
Homo sapiens (Q9BYF1)
Chen, P.; Wang, J.; Xu, X.; Li, Y.; Zhu, Y.; Li, X.; Li, M.; Hao, P.
Molecular dynamic simulation analysis of SARS-CoV-2 spike mutations and evaluation of ACE2 from pets and wild animals for infection risk
Comput. Biol. Chem.
96
107613
2022
Manis javanica, Paguma larvata (Q56NL1), Mus musculus (Q8R0I0), Homo sapiens (Q9BYF1)
Baristaite, G.; Gurwitz, D.
Estradiol reduces ACE2 and TMPRSS2 mRNA levels in A549 human lung epithelial cells
Drug Dev. Res.
2022
1-6
2022
Homo sapiens (Q9BYF1)
Sepe, S.; Rossiello, F.; Cancila, V.; Iannelli, F.; Matti, V.; Cicio, G.; Cabrini, M.; Marinelli, E.; Alabi, B.R.; di Lillo, A.; Di Napoli, A.; Shay, A.W.; Tripodo, C.; d'Adda di Fagagna, F.
DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging
EMBO Rep.
23
e53658
2022
Mus musculus (Q8R0I0), Homo sapiens (Q9BYF1)
Samanta, A.; Alam, S.; Ali, S.; Hoque, M.
Analyzing the interaction of human ACE2 and RBD of spike protein of SARS-CoV-2 in perspective of Omicron variant
EXCLI J.
21
610-620
2022
Homo sapiens (Q9BYF1)
-
Pei, G.; Xu, W.; Lan, J.; Wang, X.; Li, P.
CEBIT screening for inhibitors of the interaction between SARS-CoV-2 spike and ACE2
Fundam. Res.
2
562-569
2022
Homo sapiens (Q9BYF1)
-
Chakraborty, S.
E484K and N501Y SARS-CoV 2 spike mutants increase ACE2 recognition but reduce affinity for neutralizing antibody
Int. Immunopharmacol.
102
108424
2022
Homo sapiens (Q9BYF1)
de Bruin, N.; Schneider, A.K.; Reus, P.; Talmon, S.; Ciesek, S.; Bojkova, D.; Cinatl, J.; Lodhi, I.; Charlesworth, B.; Sinclair, S.; Pennick, G.; Laughey, W.F.; Gribbon, P.; Kannt, A.; Schiffmann, S.
Ibuprofen, flurbiprofen, etoricoxib or paracetamol do not influence ACE2 expression and activity in vitro or in mice and do not exacerbate in-vitro SARS-CoV-2 infection
Int. J. Mol. Sci.
23
1049
2022
Mus musculus (Q8R0I0), Homo sapiens (Q9BYF1)
Mishra, L.; Bandyopadhyay, T.
Unbinding of hACE2 and inhibitors from the receptor binding domain of SARS-CoV-2 spike protein
J. Biomol. Struct. Dyn.
2022
1-20
2022
Homo sapiens (Q9BYF1)
Kalhor, H.; Sadeghi, S.; Abolhasani, H.; Kalhor, H.; Rahimi, H.
Repurposing of the approved small molecule drugs in order to inhibit SARS-CoV-2 S protein and human ACE2 interaction through virtual screening approaches
J. Biomol. Struct. Dyn.
40
1299-1315
2022
Homo sapiens (Q9BYF1)
Bagheri, M.; Niavarani, A.
Molecular dynamics analysis predicts ritonavir and naloxegol strongly block the SARS-CoV-2 spike protein-hACE2 binding
J. Biomol. Struct. Dyn.
40
1597-1606
2022
Homo sapiens (Q9BYF1)
Gyebi, G.A.; Adegunloye, A.P.; Ibrahim, I.M.; Ogunyemi, O.M.; Afolabi, S.O.; Ogunro, O.B.
Prevention of SARS-CoV-2 cell entry insight from in silico interaction of drug-like alkaloids with spike glycoprotein, human ACE2, and TMPRSS2
J. Biomol. Struct. Dyn.
40
2121-2145
2022
Homo sapiens (Q9BYF1), Homo sapiens
AlGhamdi, N.A.; Alsuwat, H.S.; Borgio, J.F.; AbdulAzeez, S.
Emerging of composition variations of SARS-CoV-2 spike protein and human ACE2 contribute to the level of infection in silico approaches
J. Biomol. Struct. Dyn.
40
2635-2646
2022
Homo sapiens (Q9BYF1), Homo sapiens
Lee, J.H.; Lee, C.E.; Yoo, Y.; Shin, E.; An, J.; Park, S.Y.; Song, W.J.; Kwon, H.S.; Cho, Y.S.; Moon, H.B.; Kim, T.B.
Soluble ACE2 and TMPRSS2 levels in the serum of asthmatic patients
J. Korean Med. Sci.
37
e65
2022
Homo sapiens (Q9BYF1)
Shahbazi, B.; Mafakher, L.; Teimoori-Toolabi, L.
Different compounds against Angiotensin-Converting Enzyme 2 (ACE2) receptor potentially containing the infectivity of SARS-CoV-2 an in silico study
J. Mol. Model.
28
82
2022
Homo sapiens (Q9BYF1)
Bharathi, M.; Sivamaruthi, B.S.; Kesika, P.; Thangaleela, S.; Chaiyasut, C.
In silico screening of bioactive compounds of representative seaweeds to inhibit SARS-CoV-2 ACE2-bound omicron B.1.1.529 spike protein trimer
Mar. Drugs
20
148
2022
Homo sapiens (Q9BYF1)
Celik, I.; Khan, A.; Dwivany, F.; Fatimawal, F.; Wei, D.; Tallei, T.
Computational prediction of the effect of mutations in the receptor-binding domain on the interaction between SARS-CoV-2 and human ACE2
Mol. Divers.
FEHLT
0000
2022
Homo sapiens (Q9BYF1)
Tallei, T.E.; Fatimawali, T.E.; Adam, A.A.; Elseehy, M.M.; El-Shehawi, A.M.; Mahmoud, E.A.; Tania, A.D.; Niode, N.J.; Kusumawaty, D.; Rahimah, S.; Effendi, Y.; Idroes, R.; Celik, I.; Hossain, M.J.; Emran, T.B.
Fruit bromelain-derived peptide potentially restrains the attachment of SARS-CoV-2 variants to hACE2 A pharmacoinformatics approach
Molecules
27
260
2022
Homo sapiens
El-Shennawy, L.; Hoffmann, A.D.; Dashzeveg, N.K.; McAndrews, K.M.; Mehl, P.J.; Cornish, D.; Yu, Z.; Tokars, V.L.; Nicolaescu, V.; Tomatsidou, A.; Mao, C.; Felicelli, C.J.; Tsai, C.F.; Ostiguin, C.; Jia, Y.; Li, L.; Furlong, K.; Wysocki, J.; Luo, X.; Ruivo, C.F.; Batlle, D.; Hope, T.J.; Shen, Y.; Chae, Y.K.; Zhang, H. et al.
Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2
Nat. Commun.
13
405
2022
Homo sapiens (Q9BYF1)
Park, G.C.; Bang, S.Y.; Lee, H.W.; Choi, K.U.; Kim, J.M.; Shin, S.C.; Cheon, Y.I.; Sung, E.S.; Lee, M.; Lee, J.C.; Kim, H.S.; Lee, B.J.
ACE2 and TMPRSS2 immunolocalization and oral manifestations of COVID-19
Oral Dis.
2022
1-9
2022
Homo sapiens (Q9BYF1)
Xie, Y.; Guo, W.; Lopez-Hernadez, A.; Teng, S.; Li, L.
The pH effects on SARS-CoV and SARS-CoV-2 spike proteins in the process of binding to hACE2
Pathogens
11
238
2022
Homo sapiens (Q9BYF1)
Amraei, R.; Xia, C.; Olejnik, J.; White, M.R.; Napoleon, M.A.; Lotfollahzadeh, S.; Hauser, B.M.; Schmidt, A.G.; Chitalia, V.; Muehlberger, E.; Costello, C.E.; Rahimi, N.
Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells
Proc. Natl. Acad. Sci. USA
119
e2113874119
2022
Homo sapiens (Q9BYF1)
Heinzelman, P.; Greenhalgh, J.C.; Romero, P.A.
Yeast surface display-based identification of ACE2 mutations that modulate SARS-CoV-2 spike binding across multiple mammalian species
Protein Eng. Des. Sel.
35
gzab035
2022
Canis lupus familiaris (E2RR65), Sus scrofa (K7GLM4), Felis catus (Q56H28), Homo sapiens (Q9BYF1)
Vo, T.; Paudel, K.; Choudhary, I.; Patial, S.; Saini, Y.
Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2
Sci. Rep.
12
1357
2022
Mus musculus (Q8R0I0)
Mannar, D.; Saville, J.; Zhu, X.; Srivastava, S.; Berezuk, A.; Tuttle, K.; Marquez, A.; Sekirov, I.; Subramaniam, S.
SARS-CoV-2 Omicron variant Antibody evasion and cryo-EM structure of spike protein-ACE2 complex
Science
375
760-764
2022
Homo sapiens (Q9BYF1)
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