Information on EC 3.4.17.2 - carboxypeptidase B

Word Map on EC 3.4.17.2
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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.4.17.2
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RECOMMENDED NAME
GeneOntology No.
carboxypeptidase B
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
preferential release of a C-terminal lysine or arginine amino acid
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
carboxylic acid amide hydrolysis
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hydrolysis of peptide bond
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exopeptidase, C-terminus, amino acid
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CAS REGISTRY NUMBER
COMMENTARY hide
9025-24-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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1212259 A+, 1319473 A+, 1385481 A+, 1386572 A+, 1402373 A+, 1403132 A+, 1403150 A+, 1403160 A+, 1403165 A+, 1403170 A+, 1403175 A+, 1403185 A+, 1403197 A+, 1403211 A+, 1403257 A+, 1403260 A+, 1403265 A+, 1403274 A+, 1403275 A+, 1403278 A+, 1403279 A+, 1403284 A+, 1403291 A+, 1403294 A+, 1403303 A+, 1403334 A+, 1403341 A+, 1403374 A+, 1403390 A+, 1403391 A+, 1403393 A+, 1403403 A+, 1403409 A+, 1403415 A+, 1403420 A+, 1403447 A+, 1403469 A+, 1403477 A+, 1403512 A+, 1403520 A+, 1403537 A+, 1403541 A+, 1403560 A+, 1403575 A+, 1403576 A+, 1403619 A+, 1403669 A+, 1403686 A+, 1403687 A+, 1403767 A+, 1403792 A+, 1403917 A+, 1403953 A+, 1403987 A+, 1403995 A+, 1404085 A+, 1404110 A+, 1404168 A+, 1404193 A+, 1404262 A+, 1404266 A+, 1404322 A+, 1404327 A+, 1404334 A+, 1404361 A+, 1404379 A+, 1404391 A+, 1404513 A+, 1404531 A+, 1404575 A+, 1404589 A+, 1404617 A+, 1404660 A+, 1404737 A+, 1404771 A+, 1404773 A+, 1404864 A+, 1404929 A+, 1405007 A+, 2144198 A+, 2177462 A+, 2177479 A+, 2257070 A+, 2341160 A+, 2370144 A+, 2511757 A+, 2527190 A+, 2528282 A+, 2528288 A+, 2528301 A+, 2528307 A+, 2528312 A+, 2528338 A+, 2528436 A+, 2528492 A+, 2528496 A+, 2528500 A+, 2528551 A+, 2528630 A+, 2528643 A+, 2528677 A+, 2528716 A+, 2528759 A+, 2528881 A+, 2528916 A+, 2528929 A+, 2528976 A+, 2528986 A+, 2528997 A+, 2529033 A+, 2529056 A+, 2529095 A+, 2529123 A+, 2529266 A+, 2529377 A+, 2529422 A+, 2529435 A+, 2529450 A+, 2529462 A+, 2529472 A+, 2529560 A+, 2529576 A+, 2529660 A+, 2529662 A+, 2529842 A+, 2530016 A+, 2530021 A+, 2530057 A+, 2530217 A+, 2530323 A+, 2530366 A+, 2530587 A+, 2530727 A+, 2530786 A+, 2530788 A+, 2530798 A+, 2531002 A+, 2531109 A+, 2531253 A+, 2531409 A+, 2531499 A+, 2531543 A+, 2531703 A+, 2531775 A+, 2532014 A+, 830416 A+, 830583 A+, 842578 A+, 872302 A+, 1403206 A++, 1403363 A++, 2160839 A++, 2351944 A++
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
low levels of carboxypeptidase B
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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1053736 A+, 1067114 A+, 1227313 A+, 1318563 A+, 1319473 A+, 1402333 A+, 1403122 A+, 1403173 A+, 1403185 A+, 1403200 A+, 1403222 A+, 1403280 A+, 1403307 A+, 1403355 A+, 1403391 A+, 1403453 A+, 1403477 A+, 1403511 A+, 1403512 A+, 1403520 A+, 1403541 A+, 1403559 A+, 1403566 A+, 1403611 A+, 1403613 A+, 1403616 A+, 1403658 A+, 1403660 A+, 1403664 A+, 1403673 A+, 1403690 A+, 1403700 A+, 1403704 A+, 1403731 A+, 1403744 A+, 1403750 A+, 1403767 A+, 1403769 A+, 1403770 A+, 1403778 A+, 1403868 A+, 1403870 A+, 1403875 A+, 1403883 A+, 1403984 A+, 1404018 A+, 1404022 A+, 1404039 A+, 1404066 A+, 1404103 A+, 1404139 A+, 1404141 A+, 1404148 A+, 1404169 A+, 1404193 A+, 1404203 A+, 1404240 A+, 1404242 A+, 1404250 A+, 1404269 A+, 1404298 A+, 1404327 A+, 1404333 A+, 1404378 A+, 1404445 A+, 1404526 A+, 1404566 A+, 1404654 A+, 1404680 A+, 1404692 A+, 1404696 A+, 1404718 A+, 1404731 A+, 1404743 A+, 1404830 A+, 1404849 A+, 1404890 A+, 1404903 A+, 1404967 A+, 1405010 A+, 1405038 A+, 2105510 A+, 2115317 A+, 2125637 A+, 2411846 A+, 2504771 A+, 2528282 A+, 2528286 A+, 2528474 A+, 2528496 A+, 2528537 A+, 2528672 A+, 2528710 A+, 2528728 A+, 2528762 A+, 2528843 A+, 2528849 A+, 2528897 A+, 2528957 A+, 2528967 A+, 2528980 A+, 2529010 A+, 2529025 A+, 2529049 A+, 2529100 A+, 2529187 A+, 2529206 A+, 2529209 A+, 2529225 A+, 2529232 A+, 2529238 A+, 2529266 A+, 2529293 A+, 2529395 A+, 2529409 A+, 2529443 A+, 2529484 A+, 2529490 A+, 2529513 A+, 2529519 A+, 2529530 A+, 2529561 A+, 2529582 A+, 2529632 A+, 2529662 A+, 2529675 A+, 2529690 A+, 2529743 A+, 2529755 A+, 2529819 A+, 2529837 A+, 2529907 A+, 2529934 A+, 2530034 A+, 2530057 A+, 2530066 A+, 2530127 A+, 2530146 A+, 2530192 A+, 2530209 A+, 2530244 A+, 2530246 A+, 2530346 A+, 2530348 A+, 2530359 A+, 2530367 A+, 2530394 A+, 2530524 A+, 2530531 A+, 2530562 A+, 2530579 A+, 2530587 A+, 2530591 A+, 2530618 A+, 2530624 A+, 2530701 A+, 2530713 A+, 2530751 A+, 2530815 A+, 2530966 A+, 2530985 A+, 2531015 A+, 2531082 A+, 2531104 A+, 2531169 A+, 2531214 A+, 2531246 A+, 2531250 A+, 2531325 A+, 2531438 A+, 2531500 A+, 2531608 A+, 2531770 A+, 2531796 A+, 2531866 A+, 2531899 A+, 2531985 A+, 2532084 A+, 2532139 A+, 2532153 A+, 765226 A+, 822290 A+, 822328 A+, 869933 A+, 872302 A+, 913148 A+, 913182 A+, 1401308 A++, 1403171 A++, 2528735 A++, 653991 A++, 822194 A++, 822284 A++
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
starfish
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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1067114 A+, 1089199 A+, 1121998 A+, 1136600 A+, 1198794 A+, 1227313 A+, 1255475 A+, 1318563 A+, 1403112 A+, 1403125 A+, 1403195 A+, 1403202 A+, 1403421 A+, 1403673 A+, 1403749 A+, 1403786 A+, 1403826 A+, 1403841 A+, 1403907 A+, 1403948 A+, 1404012 A+, 1404052 A+, 1404066 A+, 1404103 A+, 1404139 A+, 1404144 A+, 1404147 A+, 1404179 A+, 1404183 A+, 1404191 A+, 1404208 A+, 1404214 A+, 1404233 A+, 1404240 A+, 1404247 A+, 1404251 A+, 1404252 A+, 1404253 A+, 1404276 A+, 1404285 A+, 1404289 A+, 1404295 A+, 1404298 A+, 1404309 A+, 1404349 A+, 1404359 A+, 1404381 A+, 1404399 A+, 1404445 A+, 1404486 A+, 1404488 A+, 1404490 A+, 1404532 A+, 1404540 A+, 1404654 A+, 1404674 A+, 1404680 A+, 1404711 A+, 1404722 A+, 1404731 A+, 1404743 A+, 1404748 A+, 1404752 A+, 1404784 A+, 1404787 A+, 1404812 A+, 1404818 A+, 1404831 A+, 1404856 A+, 1404862 A+, 1404865 A+, 1404866 A+, 1404899 A+, 1404917 A+, 1404948 A+, 1404968 A+, 1404976 A+, 1404978 A+, 1404985 A+, 1404986 A+, 1405019 A+, 1405038 A+, 2121656 A+, 2224768 A+, 2391624 A+, 2426545 A+, 2459699 A+, 2528414 A+, 2528591 A+, 2528724 A+, 2529770 A+, 2529964 A+, 2530361 A+, 2530530 A+, 2530589 A+, 2530662 A+, 2531203 A+, 2531349 A+, 2531438 A+, 2531493 A+, 2531719 A+, 2531787 A+, 2531937 A+, 2532110 A+, 653008 A+, 669629 A+, 742786 A+, 821418 A+, 822289 A+, 822303 A+, 822328 A+, 1208499 A++, 1401497 A++, 1403171 A++, 1403261 A++, 1403276 A++, 2175178 A++, 2243705 A++, 2245228 A++, 2526874 A++, 28945 A++, 742670 A++, 752393 A++, 81293 A++, 821336 A++, 821347 A++, 821445 A++, 1403206 A++, 1403402 A++, 2147965 A++, 2164030 A++, 36337 A++, 742665 A++, 742715 A++, 821392 A++, 822324 A+++, 822301 A++++, 822312 A++++
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Automatic Mining of ENzyme DAta
rumen bacterium
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Manually annotated by BRENDA team
Salaria basilisca
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Manually annotated by BRENDA team
Lef.
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Manually annotated by BRENDA team
Lef.
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Manually annotated by BRENDA team
shrimp
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Automatic Mining of ENzyme DAta
snake
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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1080529 A+, 1283802 A+, 1393380 A+, 1401508 A+, 1403165 A+, 1403227 A+, 1403235 A+, 1403264 A+, 1403307 A+, 1403355 A+, 1403407 A+, 1403416 A+, 1403453 A+, 1403489 A+, 1403492 A+, 1403551 A+, 1403563 A+, 1403574 A+, 1403583 A+, 1403602 A+, 1403642 A+, 1403660 A+, 1403665 A+, 1403675 A+, 1403678 A+, 1403690 A+, 1403692 A+, 1403698 A+, 1403726 A+, 1403731 A+, 1403769 A+, 1403770 A+, 1403801 A+, 1403808 A+, 1403835 A+, 1403875 A+, 1403882 A+, 1403921 A+, 1403956 A+, 1404108 A+, 1404141 A+, 1404160 A+, 1404242 A+, 1404268 A+, 1404269 A+, 1404291 A+, 1404341 A+, 1404416 A+, 1404423 A+, 1404466 A+, 1404475 A+, 1404495 A+, 1404522 A+, 1404539 A+, 1404566 A+, 1404569 A+, 1404595 A+, 1404597 A+, 1404633 A+, 1404692 A+, 1404777 A+, 1404797 A+, 1404849 A+, 1404890 A+, 1404930 A+, 1405011 A+, 1405014 A+, 2119456 A+, 2119479 A+, 2148230 A+, 2177816 A+, 2277142 A+, 2288822 A+, 2341091 A+, 2390420 A+, 2412923 A+, 2514515 A+, 2520647 A+, 2528346 A+, 2528399 A+, 2528415 A+, 2528480 A+, 2528637 A+, 2528640 A+, 2528678 A+, 2528789 A+, 2528830 A+, 2528871 A+, 2528876 A+, 2528943 A+, 2528957 A+, 2529065 A+, 2529089 A+, 2529100 A+, 2529124 A+, 2529167 A+, 2529225 A+, 2529343 A+, 2529358 A+, 2529362 A+, 2529394 A+, 2529395 A+, 2529508 A+, 2529513 A+, 2529514 A+, 2529593 A+, 2529595 A+, 2529652 A+, 2529658 A+, 2529743 A+, 2529748 A+, 2529837 A+, 2529934 A+, 2530007 A+, 2530246 A+, 2530345 A+, 2530395 A+, 2530399 A+, 2530470 A+, 2530485 A+, 2530524 A+, 2530550 A+, 2530553 A+, 2530558 A+, 2530562 A+, 2530729 A+, 2530730 A+, 2530749 A+, 2530851 A+, 2530861 A+, 2530863 A+, 2531081 A+, 2531099 A+, 2531104 A+, 2531169 A+, 2531214 A+, 2531344 A+, 2531500 A+, 2531660 A+, 2531828 A+, 2531875 A+, 2532139 A+, 758117 A+, 864951 A+, 913279 A+, 916015 A+, 1159727 A++, 1401308 A++, 745354 A++, 822194 A++
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-(2-furyl)acryloyl-L-Ala-L-Arg + H2O
3-(2-furyl)acryloyl-L-Ala + L-Arg
show the reaction diagram
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?
Arg-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
?
show the reaction diagram
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bradykinin
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?
benzoyl-beta-Ala-L-Lys + H2O
?
show the reaction diagram
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low activity
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?
benzoyl-Gly-Arg + H2O
benzoyl-Gly + Arg
show the reaction diagram
benzoyl-Gly-Gly-Phe + H2O
?
show the reaction diagram
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-
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?
benzoyl-Gly-glycylphenyllactic acid + H2O
?
show the reaction diagram
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?
benzoyl-Gly-L-Arg + H2O
benzoyl-Gly + L-Arg
show the reaction diagram
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?
biotin-(epsilon-aminocaproic acid)2-GLMVGGVVR + H2O
biotin-(epsilon-aminocaproic acid)2-GLMVGGVV + Arg
show the reaction diagram
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?
carbobenzoxy-Gly-L-Phe + H2O
?
show the reaction diagram
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-
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?
endostar + H2O
?
show the reaction diagram
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endostar is a derivative of human endostatin that is modified with an additional metal-chelating sequence at the N-terminus. A mixture of carboxypeptidase A and carboxypeptidase B is applied to catalyse the hydrolysis of the C-terminus of apo and holo endostar
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?
Fibrin + H2O
?
show the reaction diagram
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CPB activity generates fine-mesh fibrin which is more difficult to lyse by tPA
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?
furylacryloylalanylarginine + H2O
?
show the reaction diagram
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?
furylacryloylalanyllysine + H2O
?
show the reaction diagram
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-
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?
hippuryl-Gly + H2O
?
show the reaction diagram
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10% of the activity with hippuryl-L-Arg
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?
hippuryl-L-Arg
hippuric acid + L-Arg
show the reaction diagram
Hippuryl-L-Arg + H2O
Hippuric acid + L-Arg
show the reaction diagram
hippuryl-L-arginine + H2O
hippuric acid + L-Arg
show the reaction diagram
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-
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?
hippuryl-L-Asp + H2O
hippuric acid + Asp
show the reaction diagram
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hydrolyzed by mutant enzyme D253K and mutant enzyme D253R, wild type enzyme shows no activity
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?
hippuryl-L-Glu + H2O
hippuric acid + Glu
show the reaction diagram
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hydrolyzed by mutant enzyme D253K, wild type enzyme shows no activity
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?
hippuryl-L-homoarginine + H2O
hippuric acid + homoarginine
show the reaction diagram
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low activity
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?
hippuryl-L-Lys
hippuric acid + L-Lys
show the reaction diagram
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-
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?
hippuryl-L-Orn + H2O
hippuric acid + Orn
show the reaction diagram
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-
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?
hippuryl-L-Phe + H2O
?
show the reaction diagram
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18% of the activity with hippuryl-L-Arg
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?
hippuryl-L-Pro-L-Lys + H2O
?
show the reaction diagram
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low activity
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?
hippuryl-Lys + H2O
hippuric acid + Lys
show the reaction diagram
hippurylphenyllactic acid + H2O
hippuric acid + phenyllactic acid
show the reaction diagram
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-
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?
human insulin-like peptide 3 + H2O
?
show the reaction diagram
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the single-chain precursor of INSL3 is converted to the double-chain mature human INSL3 by endoproteinase Lys-C and carboxypeptidase B treatment. Carboxypeptidase B is added (emzyme/peptide mass ratio 1 : 30) to remove the additional lysine residue at the C-terminus of B-chain
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?
human proinsulin + H2O
?
show the reaction diagram
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enzymatic modification of human proinsulin using trypsin and carboxypeptidase B generally causes high accumulation of insulin derivatives, leading to more complicated purification processes. A simple method including citraconylation and decitraconylation in the enzymatic modification process is developed for the reduction of a major derivative, des-threonine human insulin
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?
insulin-like peptide 5 precursor + H2O
?
show the reaction diagram
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-
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?
Leu-Asp-Ser + H2O
Leu-Asp + Ser
show the reaction diagram
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-
-
?
mono/di-Arg-insulin + H2O
human insulin
show the reaction diagram
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-
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N-(4-methoxyphenylazoformyl)-Arg + H2O
?
show the reaction diagram
N-(4-methoxyphenylazoformyl)-Arg-OH + H2O
?
show the reaction diagram
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-
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?
N-(4-methoxyphenylazoformyl)-Phe + H2O
?
show the reaction diagram
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-
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?
N-benzoyl-Gly-L-Arg + H2O
N-benzoyl-Gly + L-Arg
show the reaction diagram
OPN-R + H2O
OPN-L + ?
show the reaction diagram
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osteopontin (OPN) gets activated by thrombin resulting in OPN-R. OPN-R is subsequently inactivated by CPB generating OPN-L
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?
Val-Asp-Asp-Asp-Lys + H2O
Lys + Asp + ?
show the reaction diagram
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?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Fibrin + H2O
?
show the reaction diagram
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CPB activity generates fine-mesh fibrin which is more difficult to lyse by tPA
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-
?
human proinsulin + H2O
?
show the reaction diagram
-
enzymatic modification of human proinsulin using trypsin and carboxypeptidase B generally causes high accumulation of insulin derivatives, leading to more complicated purification processes. A simple method including citraconylation and decitraconylation in the enzymatic modification process is developed for the reduction of a major derivative, des-threonine human insulin
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?
OPN-R + H2O
OPN-L + ?
show the reaction diagram
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osteopontin (OPN) gets activated by thrombin resulting in OPN-R. OPN-R is subsequently inactivated by CPB generating OPN-L
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?
additional information
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R)-2-(3-carbamimidamidophenyl)-3-sulfanylpropanoic acid
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binding structure analysis
(2S)-7-amino-2-[(hydroxy[(1R)-2-methyl-1-[(3-phenylpropanoyl)amino]propyl]phosphoryl)methyl]heptanoic acid
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(DL-5-guanidinoethyl)mercaptosuccinic acid
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(R)-2-(3-guanidinophenyl)-3-mercaptopropanoic acid
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(R)-2-guanidino-3-mercaptopropanoic acid
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(S)-2-(2-((S)-1-carboxy-2-(1H-imidazol-5-yl)ethylamino)ethylamino)-5-guanidinopentanoic acid
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IC50: 17 microgram/ml
(S)-5-amino-2-((1-propyl-1H-imidazol-4-yl)methyl)pentanoic acid
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1,10-phenanthroline
1-(4-chlorophenyl)-2-(5-(2-hydroxyphenyl)-1,3,4-oxadiazol-2-ylthio)ethanone
2-(2-chloro-5-guanidinophenyl)-3-mercaptopropanoic acid
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2-(2-guanidinoethylthio)succinic acid
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2-(3-guanidinophenyl)-3-mercaptopropanoic acid
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2-(4-(furan-2-ylmethyl)-5-(4-hydroxyphenyl)-4H-1,2,4-triazol-3-ylthio)-1-(thiophen-2-yl)ethanone
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2-(5-carbamimidamido-2-chlorophenyl)-3-sulfanylpropanoic acid
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binding structure analysis
2-(6,9-dimethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-1-(4-fluorophenyl)ethanone
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2-benzyl-3-mercaptopropanoic acid
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2-Guanidinoethylmercaptosuccinic acid
2-mercaptomethyl-3-guanidinoethyl-propanoic acid
2-mercaptomethyl-5-guanidinopentanoic acid
3-(6-amino-5-chloropyridin-3-yl)-2-(selanylmethyl)propanoic acid
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3-Phenylpropanoic acid
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3-Phenylpropionic acid
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4-(5-(2-chlorobenzylthio)-1,3,4-oxadiazol-2-yl)-N-(thiophen-2-ylmethyl)benzensulfonamide
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5-aminopentanoic acid
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5-carbamimidamido-2-(sulfanylmethyl)pentanoic acid
-
binding structure analysis
5-guanidino-2-(mercaptomethyl)pentanoic acid
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-
6-amino-n-hexanoic acid
-
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6-aminohexanoic acid
6-guanidinohexanoic acid
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7-amino-2-(selanylmethyl)heptanoic acid
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7-amino-2-(sulfanylmethyl)heptanoic acid
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7-amino-2-[(propanoylselanyl)methyl]heptanoic acid
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aminobenzylsuccinic acid
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antithrombomodulin antibody
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benzamidine
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Beta-phenylpropionic acid
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Ca2+
-
1 mM, 36% inhibition
Co2+
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hydrolysis of hippuryl-L-Arg
Cu2+
Salaria basilisca
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inhibits activity
DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid
DL-benzylsuccinic acid
DL-guanidinoethylmercaptosuccinic acid
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epsilon-aminocaproic acid
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Guanidinoethylmercaptosuccinic acid
hippuryl-D-Lys
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isopropyl 2-(4-benzyl-5-(2-methoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate
leech carboxypeptidase inhibitor
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lipopolysaccharide
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lipopolysaccharide treatment significantly decreases carboxypeptidase B activity. Administration of 5,5-dimethyl-1-pyrroline N-oxide to LPS-treated mice alleviates this loss of enzyme activity
methyl (1R,2S)-2-([[(1R,2S)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]amino)cyclobutanecarboxylate
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methyl (1S,2R)-2-([[(1S,2R)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]amino)cyclobutanecarboxylate
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methyl 2-(4-benzyl-5-(2-hydroxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate
methyl 5-([[(1S,2R)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]amino)pentanoate
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methyl N-[[(1R,2S)-2-([N-[(benzyloxy)carbonyl]-beta-alanyl]amino)cyclobutyl]carbonyl]-beta-alaninate
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methyl N-[[(1R,2S)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]-beta-alaninate
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methyl N-[[(1R,2S)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]glycinate
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Mg2+
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1 mM, 24% inhibition
N-(3-chlorophenyl)-4-((5-((3-methoxybenzyl)thio)-1,3,4-oxadiazol-2-yl)methyl)thiazol-2-amine
N-(3-chlorophenyl)-4-((5-(3-methoxybenzylthio)-1,3,4-oxadiazol-2-yl)methyl)thiazol-2-amine
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N-benzyl-N-(4-phenylthiazol-2-yl)cyclopropanecarboxamide
N-[[(1R,2S)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]-beta-alaninate
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N-[[di(propan-2-yl)amino]-[3-(4-methoxyphenyl)-2-trimethylsilyloxiran-2-yl]phosphinothioyl]-N-propan-2-ylpropan-2-amine
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Phenanthroline
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Potato carboxypeptidase inhibitor
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protamine
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tick carboxypeptidase inhibitor
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additional information
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ACTIVATING COMPOUND
ORGANISM