Reference on EC 3.4.17.10 - carboxypeptidase E
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Fricker, L.D.
Carboxypeptidase E
Annu. Rev. Physiol.
50
309-321
1988
Bos taurus, Rattus norvegicus
Grimwood, B.G.; Plummer, T.H.; Tarentino, A.L.
Carboxypeptidase H. A regulatory peptide-processing enzyme produced by human hepatoma Hep G2 cells
J. Biol. Chem.
264
15662-15667
1989
Homo sapiens
Darby, N.J.; Fricker, L.D.; Maruthainar, K.; Smyth, D.G.
A study of the substrate specificity of carboxypeptidase H
Pept. Chem. Biol. (Proc. Am. Pept. Symp. ,10th Meeting Date 1987, Marshall, G. R. , ed. )
613-614
1988
Sus scrofa
-
Rossier, J.R.; Barres, E.; Hutton, J.C.; Bicknell, R.J.
Radiometric assay for carboxypeptidase H (EC 3.4.17.10) and other carboxypeptidase B-like enzymes
Anal. Biochem.
178
27-31
1989
Rattus norvegicus
Hook, V.Y.H.; Affolter, H.U.
Identification of zymogen and mature forms of human carboxypeptidase H. A processing enzyme for the synthesis of peptide hormones
FEBS Lett.
238
338-342
1988
Homo sapiens
Hook, V.Y.H.; LaGamma, E.F.
Product inhibition of carboxypeptidase H
J. Biol. Chem.
262
12583-12588
1987
Bos taurus, Rattus norvegicus
Davidson, H.W.; Hutton, J.C.
The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing
Biochem. J.
245
575-582
1987
Rattus norvegicus
Fricker, L.D.; Evans, C.J.; Esch, F.S.; Herbert, E.
Cloning and sequence analysis of cDNA for bovine carboxypeptidase E
Nature
323
461-464
1986
Bos taurus
Fricker, L.D.; Snyder, S.H.
Enkephalin convertase: purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules
Proc. Natl. Acad. Sci. USA
79
3886-3890
1982
Bos taurus
Fricker, L.D.; Snyder, S.H.
Purification and characterization of enkephalin convertase, an enkephalin-synthesizing carboxypeptidase
J. Biol. Chem.
258
10950-10955
1983
Bos taurus
Fricker, L.D.; Devi, L.
Comparison of a spectrophotometric, a fluorometric, and a novel radiometric assay for carboxypeptidase E (EC 3.4.17.10) and other carboxypeptidase B-like enzymes
Anal. Biochem.
184
21-27
1990
Sus scrofa
Fricker, L.D.; Das, B.; Angeletti, R.H.
Identification of the pH-dependent membrane anchor of carboxypeptidase E (EC 3.4.17.10)
J. Biol. Chem.
265
2476-2482
1990
Bos taurus
Hook, V.Y.H.; Mezey, E.; Fricker, L.D.; Pruss, R.M.; Siegel, R.E.; Brownstein, M.J.
Immunochemical characterization of carboxypeptidase B-like peptide-hormone-processing enzyme
Proc. Natl. Acad. Sci. USA
82
4745-4749
1985
Bos taurus, Rattus norvegicus
Deddish, P.A.; Skidgel, R.A.; Erds, E.G.
Enhanced Co2+ activation and inhibitor binding of carboxypeptidase M at low pH. Similarity to carboxypeptidase H (enkephalin convertase)
Biochem. J.
261
289-291
1989
Homo sapiens
Juvvadi, S.; Fan, X.; Nagle, G.T.; Fricker, L.D.
Characterization of Aplysia carboxypeptidase E
FEBS Lett.
408
195-200
1997
Aplysia californica
Manser, E.; Fernandez, D.; Loo, L.; Goh, P.Y.; Monfries, C.; Hall, C.; Lim, L.
Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro
Biochem. J.
267
517-525
1990
Homo sapiens
Christie, D.L.; Palmer, D.J.
Identification and characterization of glycoproteins after extraction of bovine chromaffin-granule membranes with lithium di-iodosalicylate. Purification of glycoprotein II from the soluble fraction
Biochem. J.
270
57-61
1990
Bos taurus
Rodriguez, C.; Brayton, K.A.; Brownstein, M.; Dixon, J.E.
Rat preprocarboxypeptidase H. Cloning, characterization, and sequence of the cDNA and regulation of the mRNA by corticotropin-releasing factor
J. Biol. Chem.
264
5988-5995
1989
Mus musculus, Rattus norvegicus
Stone, T.E.; Li, J.P.; Bernasconi, P.
Purification and characterization of the Manduca sexta neuropeptide processing enzyme carboxypeptidase E
Arch. Insect Biochem. Physiol.
27
193-203
1994
Aplysia californica, Manduca sexta
Kumar, G.K.
Neuropeptide processing enzymes of the carotid body. Biochemical and immunological characterization of carboxypeptidase activity
Adv. Exp. Med. Biol.
410
319-323
1996
Felis catus
Hook, V.Y.H.
Arginine and lysine product inhibition of bovine adrenomedullary carboxypeptidase H, a prohormone processing enzyme
Life Sci.
47
1135-1139
1990
Bos taurus
Dhanvantari, S.; Arnaoutova, I.; Snell, C.R.; Steinbach, P.J.; Hammond, K.; Caputo, G.A.; London, E.; Loh, Y.P.
Carboxypeptidase E, a prohormone sorting receptor, is anchored to secretory granules via a C-terminal transmembrane insertion
Biochemistry
41
52-60
2002
Bos taurus
Dhanvantari, S.; Loh, Y.P.
Lipid raft association of carboxypeptidase E is necessary for its function as a regulated secretory pathway sorting receptor
J. Biol. Chem.
275
29887-29893
2000
Bos taurus
Wu, C.M.; Chang, H.T.; Chang, M.D.
Membrane-bound carboxypeptidase E facilitates the entry of eosinophil cationic protein into neuroendocrine cells
Biochem. J.
382
841-848
2004
Homo sapiens
Marzban, L.; Soukhatcheva, G.; Verchere, C.B.
Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in beta-cells
Endocrinology
146
1808-1817
2005
Mus musculus
Fricker, L.D.
Carboxypeptidase E
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. ) Academic Press
2
840-844
2004
Aplysia sp., Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
-
Hougaard, D.M.; Larsson, L.I.
Carboxypeptidase E in rat antropyloric mucosa: distribution in progenitor and mature endocrine cell types
Histochem. Cell Biol.
121
55-61
2004
Rattus norvegicus
He, P.; Varticovski, L.; Bowman, E.D.; Fukuoka, J.; Welsh, J.A.; Miura, K.; Jen, J.; Gabrielson, E.; Brambilla, E.; Travis, W.D.; Harris, C.C.
Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray
Hum. Pathol.
35
1196-1209
2004
Homo sapiens
Hosaka, M.; Watanabe, T.; Sakai, Y.; Kato, T.; Takeuchi, T.
Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules
J. Cell Sci.
118
4785-4795
2005
Mus musculus
Zhou, A.; Minami, M.; Zhu, X.; Bae, S.; Minthorne, J.; Lan, J.; Xiong, Z.G.; Simon, R.P.
Altered biosynthesis of neuropeptide processing enzyme carboxypeptidase E after brain ischemia: molecular mechanism and implication
J. Cereb. Blood Flow Metab.
24
612-622
2004
Mus musculus, Rattus norvegicus
Zhu, X.; Wu, K.; Rife, L.; Cawley, N.X.; Brown, B.; Adams, T.; Teofilo, K.; Lillo, C.; Williams, D.S.; Loh, Y.P.; Craft, C.M.
Carboxypeptidase E is required for normal synaptic transmission from photoreceptors to the inner retina
J. Neurochem.
95
1351-1362
2005
Mus musculus, Mus musculus C57BL/6
Ozawa, A.; Cai, Y.; Lindberg, I.
Production of bioactive peptides in an in vitro system
Anal. Biochem.
366
182-189
2007
Homo sapiens
Arolas, J.L.; Vendrell, J.; Aviles, F.X.; Fricker, L.D.
Metallocarboxypeptidases: emerging drug targets in biomedicine
Curr. Pharm. Des.
13
349-366
2007
Mammalia
Singh, U.; Yu, Y.; Kalinina, E.; Konno, T.; Sun, T.; Ohta, H.; Wakayama, T.; Soares, M.J.; Hemberger, M.; Fundele, R.H.
Carboxypeptidase E in the mouse placenta
Differentiation
74
648-660
2006
Mus musculus
Fricker, L.D.
Neuropeptidomics to study peptide processing in animal models of obesity
Endocrinology
148
4185-4190
2007
Mus musculus
Sekiguchi, T.; Kawashima, T.; Satou, Y.; Satoh, N.
Further EST analysis of endocrine genes that are preferentially expressed in the neural complex of Ciona intestinalis: receptor and enzyme genes associated with endocrine system in the neural complex
Gen. Comp. Endocrinol.
150
233-245
2007
Ciona intestinalis
Husson, S.J.; Janssen, T.; Baggerman, G.; Bogert, B.; Kahn-Kirby, A.H.; Ashrafi, K.; Schoofs, L.
Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry
J. Neurochem.
102
246-260
2007
Caenorhabditis elegans
Lim, J.; Berezniuk, I.; Che, F.Y.; Parikh, R.; Biswas, R.; Pan, H.; Fricker, L.D.
Altered neuropeptide processing in prefrontal cortex of Cpe (fat/fat) mice: implications for neuropeptide discovery
J. Neurochem.
96
1169-1181
2006
Mus musculus
Wegrzyn, J.; Lee, J.; Neveu, J.M.; Lane, W.S.; Hook, V.
Proteomics of neuroendocrine secretory vesicles reveal distinct functional systems for biosynthesis and exocytosis of peptide hormones and neurotransmitters
J. Proteome Res.
6
1652-1665
2007
Bos taurus
Park, J.J.; Cawley, N.X.; Loh, Y.P.
Carboxypeptidase E cytoplasmic tail-driven vesicle transport is key for activity-dependent secretion of peptide hormones
Mol. Endocrinol.
22
989-1005
2008
Mus musculus
Kimball, E.S.; Prouty, S.P.; Pavlick, K.P.; Wallace, N.H.; Schneider, C.R.; Hornby, P.J.
Stimulation of neuronal receptors, neuropeptides and cytokines during experimental oil of mustard colitis
Neurogastroenterol. Motil.
19
390-400
2007
Mus musculus
Billova, S.; Galanopoulou, A.S.; Seidah, N.G.; Qiu, X.; Kumar, U.
Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain
Neuroscience
147
403-418
2007
Rattus norvegicus
Wang, J.; Zhang, Y.; Yang, Z.J.; Zhu, T.B.; Wang, L.S.; Chen, B.; Cao, K.J.; Huang, J.; Ma, W.Z.; Jia, E.Z.
Association of human carboxypeptidase E exon5 gene polymorphisms with angiographical characteristics of coronary atherosclerosis in a Chinese population
Acta Pharmacol. Sin.
29
736-744
2008
Homo sapiens
Woronowicz, A.; Koshimizu, H.; Chang, S.Y.; Cawley, N.X.; Hill, J.M.; Rodriguiz, R.M.; Abebe, D.; Dorfman, C.; Senatorov, V.; Zhou, A.; Xiong, Z.G.; Wetsel, W.C.; Loh, Y.P.
Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits
Hippocampus
18
1051-1063
2008
Mus musculus
Park, J.J.; Cawley, N.X.; Loh, Y.P.
A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons
Mol. Cell. Neurosci.
39
63-73
2008
Rattus norvegicus
Zhang, X.; Zhu, J.; Loh, Y.P.; Berghman, L.R.
Carboxypeptidase E, an essential element of the regulated secretory pathway, is expressed and partially co-localized with chromogranin A in chicken thymus
Cell Tissue Res.
337
371-379
2009
Gallus gallus
Koshimizu, H.; Senatorov, V.; Loh, Y.P.; Gozes, I.
Neuroprotective protein and carboxypeptidase E
J. Mol. Neurosci.
39
1-8
2009
Mus musculus
Oiso, S.; Takeda, Y.; Futagawa, T.; Miura, T.; Kuchiiwa, S.; Nishida, K.; Ikeda, R.; Kariyazono, H.; Watanabe, K.; Yamada, K.
Contactin-associated protein (Caspr) 2 interacts with carboxypeptidase E in the CNS
J. Neurochem.
109
158-167
2009
Homo sapiens
Lou, H.; Park, J.J.; Cawley, N.X.; Sarcon, A.; Sun, L.; Adams, T.; Peng Loh, Y.
Carboxypeptidase E cytoplasmic tail mediates localization of synaptic vesicles to the pre-active zone in hypothalamic presynaptic terminals
J. Neurochem.
114
886-896
2010
Mus musculus (Q00493)
Woronowicz, A.; Cawley, N.X.; Chang, S.Y.; Koshimizu, H.; Phillips, A.W.; Xiong, Z.G.; Loh, Y.P.
Carboxypeptidase E knockout mice exhibit abnormal dendritic arborization and spine morphology in central nervous system neurons
J. Neurosci. Res.
88
64-72
2010
Mus musculus
Carrel, D.; Du, Y.; Komlos, D.; Hadzimichalis, N.M.; Kwon, M.; Wang, B.; Brzustowicz, L.M.; Firestein, B.L.
NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway
J. Neurosci.
29
8248-8258
2009
Rattus norvegicus
Jia, E.; Wang, J.; Yang, Z.; Zhu, T.; Wang, L.; Wang, H.; Li, C.; Chen, B.; Cao, K.; Huang, J.; Ma, W.
Association of the mutation for the human carboxypeptidase e gene exon 4 with the severity of coronary artery atherosclerosis
Mol. Biol. Rep.
36
245-254
2009
Homo sapiens (P16870), Homo sapiens
Zhang, H.; Li, S.; Wang, M.; Vukusic, B.; Pristupa, Z.B.; Liu, F.
Regulation of dopamine transporter activity by carboxypeptidase E
Mol. Brain
2
10
2009
Homo sapiens, synthetic construct
Murthy, S.R.; Thouennon, E.; Li, W.S.; Cheng, Y.; Bhupatkar, J.; Cawley, N.X.; Lane, M.; Merchenthaler, I.; Loh, Y.P.
Carboxypeptidase E protects hippocampal neurons during stress in male mice by up-regulating prosurvival BCL2 protein expression
Endocrinology
154
3284-3293
2013
Mus musculus
Kumar, S.; Tomar, A.K.; Singh, S.; Gill, K.; Dey, S.; Singh, S.; Yadav, S.
Heparin binding carboxypeptidase E protein exhibits antibacterial activity in human semen
Int. J. Biol. Macromol.
64
319-327
2014
Homo sapiens
McGirr, R.; Guizzetti, L.; Dhanvantari, S.
The sorting of proglucagon to secretory granules is mediated by carboxypeptidase E and intrinsic sorting signals
J. Endocrinol.
217
229-240
2013
Homo sapiens
Cheng, Y.; Cawley, N.; Loh, Y.
Carboxypeptidase E/NFalpha1: A New Neurotrophic Factor against Oxidative Stress-Induced Apoptotic Cell Death Mediated by ERK and PI3-K/AKT Pathways
PLoS ONE
8
e71578
2013
Mus musculus
Baer, F.; Foeh, B.; Pagel, R.; Schroeder, T.; Schlichting, H.; Hirose, M.; Lemcke, S.; Klinger, A.; Koenig, P.; Karsten, C.M.; Buening, J.; Lehnert, H.; Fellermann, K.; Ibrahim, S.M.; Sina, C.
Carboxypeptidase E modulates intestinal immune homeostasis and protects against experimental colitis in mice
PLoS ONE
9
e102347
2014
Mus musculus
Qin, X.Y.; Cheng, Y.; Murthy, S.R.; Selvaraj, P.; Loh, Y.P.
carboxypeptidase E-DELTAN, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity
PLoS ONE
9
e112996
2014
Mus musculus
Liew, C.W.; Assmann, A.; Templin, A.T.; Raum, J.C.; Lipson, K.L.; Rajan, S.; Qiang, G.; Hu, J.; Kawamori, D.; Lindberg, I.; Philipson, L.H.; Sonenberg, N.; Goldfine, A.B.; Stoffers, D.A.; Mirmira, R.G.; Urano, F.; Kulkarni, R.N.
Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic beta cells
Proc. Natl. Acad. Sci. USA
111
E2319-E2328
2014
Mus musculus
Ji, L.; Wu, H.T.; Qin, X.Y.; Lan, R.
Dissecting carboxypeptidase E properties, functions and pathophysiological roles in disease
Endocr. Connect.
6
R18-R38
2017
Homo sapiens (P16870), Mus musculus (Q00493)
Xiao, L.; Yang, X.; Sharma, V.K.; Loh, Y.P.
Cloning, gene regulation, and neuronal proliferation functions of novel N-terminal-truncated carboxypeptidase E/neurotrophic factor-alphaIl variants in embryonic mouse brain
FASEB J.
33
808-820
2019
Mus musculus (Q00493), Mus musculus
Xiao, L.; Yang, X.; Loh, Y.P.
Neurotrophic, gene regulation, and cognitive functions of carboxypeptidase E-neurotrophic factor-alpha1 and its variants
Front. Neurosci.
13
243
2019
Homo sapiens (P16870), Mus musculus (Q00493)
Armento, A.; Ilina, E.I.; Kaoma, T.; Muller, A.; Vallar, L.; Niclou, S.P.; Krueger, M.A.; Mittelbronn, M.; Naumann, U.
Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors
Int. J. Oncol.
51
702-714
2017
Mus musculus (Q00493), Mus musculus
Mizutani, A.; Inoko, H.; Tanaka, M.
Carboxypeptidase E, identified as a direct interactor of growth hormone, is important for efficient secretion of the hormone
Mol. Cells
39
756-761
2016
Homo sapiens (P16870), Homo sapiens
Sun, J.; Meng, D.; Li, L.; Tian, X.; Jia, Y.; Wang, H.; Yu, H.; Sun, T.; Qu, A.; Shen, H.; Bao, J.; Zhang, G.
N-terminal truncated carboxypeptidase E expression is associated with poor prognosis of lung adenocarcinoma
Oncol. Lett.
12
4659-4664
2016
Homo sapiens (P16870), Homo sapiens
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