Any feedback?
Information on EC 3.4.17.10 - carboxypeptidase E and Organism(s) Mus musculus and UniProt Accession Q00493
for references in articles please use BRENDA:EC3.4.17.10Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
3.4.17.10 carboxypeptidase ESpecify your search results
Word Map
- 3.4.17.10
-
cytopathic
-
carbapenemase-producing
- enterobacteriaceae
- clostridium
- perfringens
- enterotoxin
- viruses
- carbapenemase
- pneumonia
-
electrode
- klebsiella
- neuropeptides
-
cloud
-
outbreak
-
preconcentration
-
carriage
-
swab
- enterobacterales
-
cytopathogenic
-
carba
- meropenem
-
voltammetric
-
polyelectrolyte
-
carbapenem-resistant
-
cardiogenic
-
blaoxa-48
- colistin
-
oxa-48-like
-
alpha-amidating
-
esbls
- enteroviruses
- imipenem
- vim
- ertapenem
- proinsulin
-
antibiotic-associated
- claudin-4
-
blakpc
-
tcid50
-
blandm
-
extended-spectrum
-
kpc-producing
- medicine
-
spiritual
- diagnostics
- blaimp
-
esbl-producing
-
parapneumonic
-
hodge
-
eucast
- biotechnology
- drug development
-
macconkey
-
stewardship
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
cpe, carboxypeptidase e, carboxypeptidase h, metallocarboxypeptidase, enkephalin convertase, membrane-bound carboxypeptidase, egl-21, carboxypeptidase e/h, prohormone processing carboxypeptidase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
carboxypeptidase E
carboxypeptidase, enkephalin precursor
-
-
-
-
cobalt stimulated chromaffin granule carboxypeptidase
-
-
-
-
CPE
CPH
-
-
-
-
enkephalin convertase
-
-
-
-
enkephalin precursor carboxypeptidase
-
-
-
-
enkephalin-precursor endopeptidase
-
-
-
-
insulin granule-associated carboxypeptidase
-
-
-
-
membrane-bound carboxypeptidase
-
-
-
-
peptidyl-L-lysine(-L-arginine) hydrolase
-
-
-
-
Prohormone processing carboxypeptidase
-
-
-
-
additional information
-
the enzyme belongs to the family of metallocarboxypeptidases
carboxypeptidase E
-
-
-
-
carboxypeptidase E
-
-
CPE
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
CAS REGISTRY NUMBER
COMMENTARY
81876-95-1
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
pro-islet amyloid polypeptide + H2O
islet amyloid polypeptide + pro-islet amyloid polypeptide propeptide
pro-islet amyloid polypeptide + H2O
islet amyloid polypeptide + pro-islet amyloid polypeptide propeptide
-
processing
-
-
?
pro-islet amyloid polypeptide + H2O
islet amyloid polypeptide + pro-islet amyloid polypeptide propeptide
-
processing in pancreatic beta-cells
-
-
?
additional information
?
-
-
altered biosynthesis of the neuropeptide processing enzyme after brain ischemia: molecular mechanism and implication
-
-
?
additional information
?
-
-
carboxypeptidase E is required for normal synaptic transmission from photoreceptors to the inner retina
-
-
?
additional information
?
-
-
interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules, both proteins form the separate functional sorting complex by anchoring in the cholesterol-rich membranes of the secretory granules, overview, secretogranin III can funtionally compensate for CPEin enzyme-defective mutant mice
-
-
?
additional information
?
-
-
the enzyme contributes to the sorting of proteins into the secretory pathway, and is involved in the biosynthesis of several peptide hormones and neurotransmitters
-
-
?
additional information
?
-
-
the enzyme removes C-terminal basic residues, Arg, Lys, and to a minor extent also His, from a variety of substrates, but shows no activity against nonbasic residues, the enzyme prefers Met at the P1 position but tolerates all amino acids, showing low activity in cleaving Pro-Arg bonds, it has a preference for tri- and tetrapeptides compared to dipeptides
-
-
?
additional information
?
-
-
biosynthesis of neuropeptides and peptide hormones
-
-
?
additional information
?
-
-
release of C-terminal arginine or lysine residues from polypeptides
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
pro-islet amyloid polypeptide + H2O
islet amyloid polypeptide + pro-islet amyloid polypeptide propeptide
-
processing in pancreatic beta-cells
-
-
?
additional information
?
-
-
altered biosynthesis of the neuropeptide processing enzyme after brain ischemia: molecular mechanism and implication
-
-
?
additional information
?
-
-
carboxypeptidase E is required for normal synaptic transmission from photoreceptors to the inner retina
-
-
?
additional information
?
-
-
interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules, both proteins form the separate functional sorting complex by anchoring in the cholesterol-rich membranes of the secretory granules, overview, secretogranin III can funtionally compensate for CPEin enzyme-defective mutant mice
-
-
?
additional information
?
-
-
the enzyme contributes to the sorting of proteins into the secretory pathway, and is involved in the biosynthesis of several peptide hormones and neurotransmitters
-
-
?
additional information
?
-
-
biosynthesis of neuropeptides and peptide hormones
-
-
?
additional information
?
-
-
release of C-terminal arginine or lysine residues from polypeptides
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
excessive secretogranin III leads to a decrease in CPE-bound proopiomelanocortin-derived intermediate molecules
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
allyl isothiocyanate
-
mRNA for carboxypeptidase E is transiently increased in the first 6 h, after which is decreased to below baseline levels, after intracolonically administration of allyl isothiocyanate
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
metabolic parameters of wild-type, heterozygous and homozygeous enzyme-deficient mutant mice, overview
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
transiently expressed in mouse embryos from embryonic day 5.5 to postnatal day 1
-
specifically expressed in enteroendocrine cell of the murine colon and ileum
an N-terminal-truncated CPE/NF-alpha1 variant, a 40-kDa protein, is exclusively expressed in embryonic neurons
-
after mild chronic restraint stress, CPE protein and mRNA are significantly elevated in the hippocampal CA3 region, compared to naive littermate
-
CPE-DELTAN expression is up-regulated in embryonic hippocampal neurons in response to dexamethasone treatment
-
beta cells lacking the insulin receptor show a decreased expression of CPE. CPE protein expression is up-regulated upon insulin stimulation
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
the enzyme is produced from pro-carboxypeptidase E and exists in soluble and membrane forms
the enzyme is produced from pro-carboxypeptidase E and exists in soluble and membrane forms
-
-
the enzyme binds specifically to cholesterol-rich secretory granule membranes competing with secretogranin III, excessive secretogranin III leads to a decrease in CPE-bound proopiomelanocortin-derived intermediate molecules
additional information
-
subcellular localization of wild-type and mutant enzymes in the retina, overview
-
-
the enzyme is sorted into the secretory pathway via its C-terminal domain
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
in two types of carboxypeptidase E mutant mice, Cpefat/Cpefat and Cpe knockout, loss of normal carboxypeptidase E leads to a lot of disorders, including diabetes, hyperproinsulinemia, low bone mineral density and deficits in learning and memory
physiological function
malfunction
-
cpe -/- mice is used as a model of EEC dysfunction. Using this model it is shown that CPE exhibits a relevant for EEC function and intestinal homeostasis
physiological function
physiological function
glutamatergic and acetylcholine synaptic vesicles in the hypothalamus and chromaffin cell-derived PC12 cells employ the transmembrane carboxypeptidase E cytoplasmic tail to interact with gamma-adducin for recruiting synaptic vesicles to the active and/or pre-active zone to facilitate neurotransmitter release. Carboxypeptidase E is a mediator in the process, that mediates localization of synaptic vesicles to the pre-active zone. Carboxypeptidase E has a non-enzymatic role in the control of classical neurotransmitter release in specific neuron
physiological function
overexpression of the secreted form of CPE is accompanied by differential regulation of mRNAs connected to the motility-associated networks, among others adhesion kinase FAK, p21-activated kinase PAK, cell division cycle 42 (Cdc42), integrin, STAT3 as well as TGF-beta. Especially SLUG is downregulated in sCPE-overexpressing glioma cells, paralleled by reduced expression of matrix-metalloproteinases (MMP) and, in consequence, by decreased cell migration. Expression of SLUG is regulated by ERK since inhibition of ERK reverted sCPE-mediated SLUG downregulation and enhanced cell motility. In a mouse glioma model, overexpression of the sectreted form of CPE significantly prolonges survival
physiological function
the enzyme cleaves C-terminal basic amino acids from prohormone intermediates to produce mature peptide hormones and neuropeptides in the endocrine and central nervous systems. It also plays a critical role in prohormone sorting and secretory vesicle transportation. The enzyme exerts multiple non-enzymatic physiological roles in maintaining normal central nervous system function and in neurodevelopment. This includes potent neuroprotective and anti-depressant activities, as well as stem cell differentiation functions. In addition, N-terminal truncated variants of the enzyme regulate expression of important neurodevelopmental genes
physiological function
the enzyme is involved in proneuropeptide processing. It is also a neurotrophic factor (NF-a1) and has important roles in neuroprotection, stem cell differentiation, and neurite outgrowth, independent of enzymatic activity
physiological function
the enzyme is involved in the biosynthesis of a wide range of neuropeptides and peptide hormones in endocrine tissues, and in the nervous system. Membrane carboxypeptidase E mediates the targeting of prohormones to the regulated secretory pathway, while soluble carboxypeptidase E acts as an exopeptidase and cleaves C-terminal basic residues from peptide intermediates to generate bioactive peptides. Carboxypeptidase E also participates in protein internalization, vesicle transport and regulation of signaling pathways
physiological function
the enzyme plays a critical role in prohormone sorting and secretory vesicle transportation
physiological function
-
carboxypeptidase E is classically known as an exopeptidase that cleaves carboxy-terminal basic aminoacids from neuropeptide and peptide hormone intermediates resulting in the production of bioactive peptides inneuroendocrine cells. Carboxypeptidase E that is expressed in the nervous and endocrine systems plays multiple non-enzymatic roles in addition to being an exopeptidase The soluble form of carboxypeptidase E acts as a processing enzyme. The membrane-bound form of carboxypeptidase E serves as a sorting receptor for some proneuropeptides and pro-brain derived neurotrophic factor to target them into the regulated secretory pathway.The cytoplasmic tail of the transmembrane form of carboxypeptidase E is shown to be a key molecule in the anchoring of adrenocorticotropic hormone and brain derived neurotrophic factor vesicles to the microtubule-based transport system for post-Golgi delivery of the vesicles to the release site
physiological function
-
carboxypeptidase E plays a role in regulating proper dendritic patterning, especially dendritic pruning and spine formation that are necessary for appropriate synaptogenesis and the establishment of neuronal network
physiological function
-
CPE acts extracellularly through activation of ERK and AKT signaling pathways to up-regulate expression of the anti-apoptotic protein BCL-2 to mediate neuroprotection of neurons during stress
physiological function
-
CPE can mediate neuroprotection of the hippocampal neurons during mild chronic restraint stress and may play an important role in maintaining allostasis
physiological function
-
CPE-DELTA neuroprotects neurons against glutamate neuroexcitotoxicity and H2O2-induced oxidative stress.CPE-DELTAN acts by increasing the transcription and secretion of fibroblast growth factor (FGF2)
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). CBPE_MOUSE
476
0
53256
Swiss-Prot
Secretory Pathway (Reliability: 1)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
S202P
additional information
S202P
-
enzyme-defective mutant CPEfat/fat mice show a point mutation in the coding region of the gene encoding the enzyme, and lack enzyme activity completely, which affects peptide processing the mutant mice
S202P
-
inactive mutant, mice without carboxypeptidase E activity are overweight
additional information
an N-terminal-truncated CPE/NF-alpha1 variant, a 40-kDa protein, is exclusively expressed in embryonic neurons
additional information
-
an N-terminal-truncated CPE/NF-alpha1 variant, a 40-kDa protein, is exclusively expressed in embryonic neurons
additional information
-
a spontaneous Cpefat/fat mutant strain produces an inactive enzyme, which results in diminished cell survival after ischemic stress in the brain in vivo and in neuronal cells in vitro, overview
additional information
-
enzyme-defective CPEfat mice show elevated levels of secretogranin III and chromogranin A in the pituitary compensating for the lacking CPE sorting function, overview
additional information
-
metabolic analysis of female and male heterozygous and homozygeous enzyme-deficient mutant mice, CPEfat/fat, in comparison to the wild-type mice, the mutant mice show reduced pro-islet amyloid polypeptide processing activity and reduced levels of PC2-chaperone protein 7B2 and prohormone invertase PC2, but not PC1/3, in beta cells, overview
additional information
-
mutant mice lacking the enzyme and mutant mice with defective enzymes, Cpefat/fat and Cpefat/+ mutants, show abnormal electroretinography responses, overview
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant GST-fusion protein from Escherichia coli strain BL21(DE3) by glutathione affinity, native pro- or mature enzyme from AtT20 cells, best at pH 5.5 in presence of Ca2+ by GST-secretogranin III affinity
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
N-terminal-truncated carboxypeptidase E/neurotrophic factor-alpha1 variants in embryonic mouse brain. It has an important, enzymatically independent role in the regulation of genes critical for neurodevelopment
a GST-tagged CPE tail fragment is generated using the pGEX4T-2 vector, furthermore the vectors pEGFP-1C, pDsRed2 and pCMV-Myc are used to generate GFP, RFP and Myc fusion proteins
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
after mild chronic restraint stress, CPE protein and mRNA are significantly elevated in the hippocampal CA3 region, compared to naïve littermate
-
CPE protein expression is up-regulated by insulin stimulation in beta cells lacking the insulin receptor
-
CPE-DELTAN expression is up-regulated in embryonic hippocampal neurons in response to dexamethasone treatment
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rodriguez, C.; Brayton, K.A.; Brownstein, M.; Dixon, J.E.
Rat preprocarboxypeptidase H. Cloning, characterization, and sequence of the cDNA and regulation of the mRNA by corticotropin-releasing factor
J. Biol. Chem.
264
5988-5995
1989
Mus musculus, Rattus norvegicus
Marzban, L.; Soukhatcheva, G.; Verchere, C.B.
Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in beta-cells
Endocrinology
146
1808-1817
2005
Mus musculus
Fricker, L.D.
Carboxypeptidase E
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. ) Academic Press
2
840-844
2004
Aplysia sp., Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
-
Hosaka, M.; Watanabe, T.; Sakai, Y.; Kato, T.; Takeuchi, T.
Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules
J. Cell Sci.
118
4785-4795
2005
Mus musculus
Zhou, A.; Minami, M.; Zhu, X.; Bae, S.; Minthorne, J.; Lan, J.; Xiong, Z.G.; Simon, R.P.
Altered biosynthesis of neuropeptide processing enzyme carboxypeptidase E after brain ischemia: molecular mechanism and implication
J. Cereb. Blood Flow Metab.
24
612-622
2004
Mus musculus, Rattus norvegicus
Zhu, X.; Wu, K.; Rife, L.; Cawley, N.X.; Brown, B.; Adams, T.; Teofilo, K.; Lillo, C.; Williams, D.S.; Loh, Y.P.; Craft, C.M.
Carboxypeptidase E is required for normal synaptic transmission from photoreceptors to the inner retina
J. Neurochem.
95
1351-1362
2005
Mus musculus, Mus musculus C57BL/6
Singh, U.; Yu, Y.; Kalinina, E.; Konno, T.; Sun, T.; Ohta, H.; Wakayama, T.; Soares, M.J.; Hemberger, M.; Fundele, R.H.
Carboxypeptidase E in the mouse placenta
Differentiation
74
648-660
2006
Mus musculus
Fricker, L.D.
Neuropeptidomics to study peptide processing in animal models of obesity
Endocrinology
148
4185-4190
2007
Mus musculus
Lim, J.; Berezniuk, I.; Che, F.Y.; Parikh, R.; Biswas, R.; Pan, H.; Fricker, L.D.
Altered neuropeptide processing in prefrontal cortex of Cpe (fat/fat) mice: implications for neuropeptide discovery
J. Neurochem.
96
1169-1181
2006
Mus musculus
Park, J.J.; Cawley, N.X.; Loh, Y.P.
Carboxypeptidase E cytoplasmic tail-driven vesicle transport is key for activity-dependent secretion of peptide hormones
Mol. Endocrinol.
22
989-1005
2008
Mus musculus
Kimball, E.S.; Prouty, S.P.; Pavlick, K.P.; Wallace, N.H.; Schneider, C.R.; Hornby, P.J.
Stimulation of neuronal receptors, neuropeptides and cytokines during experimental oil of mustard colitis
Neurogastroenterol. Motil.
19
390-400
2007
Mus musculus
Woronowicz, A.; Koshimizu, H.; Chang, S.Y.; Cawley, N.X.; Hill, J.M.; Rodriguiz, R.M.; Abebe, D.; Dorfman, C.; Senatorov, V.; Zhou, A.; Xiong, Z.G.; Wetsel, W.C.; Loh, Y.P.
Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits
Hippocampus
18
1051-1063
2008
Mus musculus
Koshimizu, H.; Senatorov, V.; Loh, Y.P.; Gozes, I.
Neuroprotective protein and carboxypeptidase E
J. Mol. Neurosci.
39
1-8
2009
Mus musculus
Lou, H.; Park, J.J.; Cawley, N.X.; Sarcon, A.; Sun, L.; Adams, T.; Peng Loh, Y.
Carboxypeptidase E cytoplasmic tail mediates localization of synaptic vesicles to the pre-active zone in hypothalamic presynaptic terminals
J. Neurochem.
114
886-896
2010
Mus musculus (Q00493)
Woronowicz, A.; Cawley, N.X.; Chang, S.Y.; Koshimizu, H.; Phillips, A.W.; Xiong, Z.G.; Loh, Y.P.
Carboxypeptidase E knockout mice exhibit abnormal dendritic arborization and spine morphology in central nervous system neurons
J. Neurosci. Res.
88
64-72
2010
Mus musculus
Murthy, S.R.; Thouennon, E.; Li, W.S.; Cheng, Y.; Bhupatkar, J.; Cawley, N.X.; Lane, M.; Merchenthaler, I.; Loh, Y.P.
Carboxypeptidase E protects hippocampal neurons during stress in male mice by up-regulating prosurvival BCL2 protein expression
Endocrinology
154
3284-3293
2013
Mus musculus
Cheng, Y.; Cawley, N.; Loh, Y.
Carboxypeptidase E/NFalpha1: A New Neurotrophic Factor against Oxidative Stress-Induced Apoptotic Cell Death Mediated by ERK and PI3-K/AKT Pathways
PLoS ONE
8
e71578
2013
Mus musculus
Baer, F.; Foeh, B.; Pagel, R.; Schroeder, T.; Schlichting, H.; Hirose, M.; Lemcke, S.; Klinger, A.; Koenig, P.; Karsten, C.M.; Buening, J.; Lehnert, H.; Fellermann, K.; Ibrahim, S.M.; Sina, C.
Carboxypeptidase E modulates intestinal immune homeostasis and protects against experimental colitis in mice
PLoS ONE
9
e102347
2014
Mus musculus
Qin, X.Y.; Cheng, Y.; Murthy, S.R.; Selvaraj, P.; Loh, Y.P.
carboxypeptidase E-DELTAN, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity
PLoS ONE
9
e112996
2014
Mus musculus
Liew, C.W.; Assmann, A.; Templin, A.T.; Raum, J.C.; Lipson, K.L.; Rajan, S.; Qiang, G.; Hu, J.; Kawamori, D.; Lindberg, I.; Philipson, L.H.; Sonenberg, N.; Goldfine, A.B.; Stoffers, D.A.; Mirmira, R.G.; Urano, F.; Kulkarni, R.N.
Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic beta cells
Proc. Natl. Acad. Sci. USA
111
E2319-E2328
2014
Mus musculus
Ji, L.; Wu, H.T.; Qin, X.Y.; Lan, R.
Dissecting carboxypeptidase E properties, functions and pathophysiological roles in disease
Endocr. Connect.
6
R18-R38
2017
Homo sapiens (P16870), Mus musculus (Q00493)
Xiao, L.; Yang, X.; Sharma, V.K.; Loh, Y.P.
Cloning, gene regulation, and neuronal proliferation functions of novel N-terminal-truncated carboxypeptidase E/neurotrophic factor-alphaIl variants in embryonic mouse brain
FASEB J.
33
808-820
2019
Mus musculus (Q00493), Mus musculus
Xiao, L.; Yang, X.; Loh, Y.P.
Neurotrophic, gene regulation, and cognitive functions of carboxypeptidase E-neurotrophic factor-alpha1 and its variants
Front. Neurosci.
13
243
2019
Homo sapiens (P16870), Mus musculus (Q00493)
Armento, A.; Ilina, E.I.; Kaoma, T.; Muller, A.; Vallar, L.; Niclou, S.P.; Krueger, M.A.; Mittelbronn, M.; Naumann, U.
Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors
Int. J. Oncol.
51
702-714
2017
Mus musculus (Q00493), Mus musculus
EXTERNAL LINKS (specific for EC-Number 3.4.17.10)
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
