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Disease on EC 3.4.16.2 - lysosomal Pro-Xaa carboxypeptidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Kidney Injury
What is the Best Therapy for Toxicity in the Setting of Methotrexate-Associated Acute Kidney Injury: High-Flux Hemodialysis or Carboxypeptidase G2?
Adenocarcinoma
New Prostate Cancer Targets for Diagnosis, Imaging, and Therapy: Focus on Prostate-Specific Membrane Antigen.
Alzheimer Disease
A human carboxypeptidase E/NF-?1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice.
Anaphylaxis
Cellulose Acetate Beads Activate the Complement System but Inactivate the Anaphylatoxins Generated.
[Changes of prostaglandin D2,carboxypeptidase A3 and platelet activating factor in guinea pig in anaphylactic shock].
Angioedemas, Hereditary
Metallopeptidase activities in hereditary angioedema: effect of androgen prophylaxis on plasma aminopeptidase P.
Asthma
A sputum 6-gene signature predicts future exacerbations of poorly controlled asthma.
Carboxypeptidase inhibition by NvCI suppresses airway hyperreactivity in a mouse asthma model.
Mast cells, their subtypes, and relation to asthma phenotypes.
[Thrombin activatable fibrinolysis inhibitor (TAFI) in allergic asthma patients]
Atherosclerosis
The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis.
Breast Neoplasms
Moderate Beer Consumption Modifies Tumoral Growth Parameters and Pyrrolidone Carboxypeptidase Type-I and Type-II Specific Activities in the Hypothalamus-Pituitary-Mammary Gland Axis in an Animal Model of Breast Cancer.
Neoadjuvant chemotherapy modifies serum pyrrolidone carboxypeptidase specific activity in women with breast cancer and influences circulating levels of GnRH and gonadotropins.
Putative relationship between hormonal status and serum pyrrolidone carboxypeptidase activity in pre- and post- menopausal women with breast cancer.
Pyrrolidon carboxypeptidase activities in the hypothalamus-pituitary-thyroid and hypothalamus-pituitary-ovary axes of rats with mammary gland cancer induced by N-methyl nitrosourea.
Serum pyrrolidone carboxypeptidase activity in N-methyl-nitrosourea induced rat breast cancer.
Carcinogenesis
Tumor suppressor RARRES1 links tubulin deglutamylation to mitochondrial metabolism and cell survival.
Carcinoma
Associations of carboxypeptidase 4 with ALDH1A1 expression and their prognostic value in esophageal squamous cell carcinoma.
Prostate-specific membrane antigen directed selective thrombotic infarction of tumors.
Carcinoma, Hepatocellular
Carboxypeptidase A6 Promotes the Proliferation and Migration of Hepatocellular Carcinoma by Up-regulating AKT Signaling Pathway.
Characterization of the carboxypeptidase N secreted by Hep G2 cells.
Expression of Carboxypeptidase X M14 Family Member 2 Accelerates the Progression of Hepatocellular Carcinoma via Regulation of the gp130/JAK2/Stat1 Pathway.
Cardiovascular Diseases
Angiotensin-converting enzyme 2 in the brain: properties and future directions.
Indoxyl Sulfate Downregulates Mas Receptor via Aryl Hydrocarbon Receptor/Nuclear Factor-kappa B, and Induces Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells.
Chagas Disease
Characterization of a lysosomal serine carboxypeptidase from Trypanosoma cruzi.
Choriocarcinoma
The potential of carboxypeptidase G2-antibody conjugates as anti-tumour agents. I. Preparation of antihuman chorionic gonadotrophin-carboxypeptidase G2 and cytotoxicity of the conjugate against JAR choriocarcinoma cells in vitro.
Ciliary Motility Disorders
Further studies on lymphocyte beta-glucuronidase abnormality in cystic fibrosis. Possible relations to carboxypeptidase B-like activity.
Colitis, Ulcerative
Carboxypeptidase A6 was identified and validated as a novel potential biomarker for predicting the occurrence of active ulcerative colitis.
Enzymes degrading bacterial chemotactic F-met peptides in human ileal and colonic mucosa.
Colorectal Neoplasms
MicroRNA-146a promote cell migration and invasion in human colorectal cancer via carboxypeptidase M/src-FAK pathway.
Crohn Disease
Enzymes degrading bacterial chemotactic F-met peptides in human ileal and colonic mucosa.
Cystic Fibrosis
Carboxypeptidase B-like activity and C3 in cystic fibrosis.
Deficiency of serum carboxypeptidase B-like (anaphylatoxin inactivator, carboxypeptidase N) activity in sera from patients with cystic fibrosis.
Further studies on lymphocyte beta-glucuronidase abnormality in cystic fibrosis. Possible relations to carboxypeptidase B-like activity.
Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter.
Dementia
A human carboxypeptidase E/NF-?1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice.
Diabetes Mellitus
Prolyl carboxypeptidase activity decline correlates with severity and short-term outcome in acute ischemic stroke.
Diabetes Mellitus, Type 2
Co-localization of acinar markers and insulin in pancreatic cells of subjects with type 2 diabetes.
Disseminated Intravascular Coagulation
Plasma antigen levels of thrombin-activatable fibrinolysis inhibitor did not differ in patients with or without disseminated intravascular coagulation.
Duane Retraction Syndrome
Carboxypeptidase A6 in zebrafish development and implications for VIth cranial nerve pathfinding.
Substrate specificity of human carboxypeptidase A6.
Encephalomyelitis
Carboxypeptidase N-deficient mice present with polymorphic disease phenotypes on induction of experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Carboxypeptidase N-deficient mice present with polymorphic disease phenotypes on induction of experimental autoimmune encephalomyelitis.
Epilepsy
Carboxypeptidase A6 gene (CPA6) mutations in a recessive familial form of febrile seizures and temporal lobe epilepsy and in sporadic temporal lobe epilepsy.
Carboxypeptidase A6 Promotes the Proliferation and Migration of Hepatocellular Carcinoma by Up-regulating AKT Signaling Pathway.
Naturally occurring carboxypeptidase A6 mutations: effect on enzyme function and association with epilepsy.
Epilepsy, Generalized
Novel carboxypeptidase A6 (CPA6) mutations identified in patients with juvenile myoclonic and generalized epilepsy.
Epilepsy, Temporal Lobe
Carboxypeptidase A6 gene (CPA6) mutations in a recessive familial form of febrile seizures and temporal lobe epilepsy and in sporadic temporal lobe epilepsy.
Erectile Dysfunction
I/D genetic polymorphism of angiotensin-converting enzyme: pathogenesis evaluation for erectile dysfunction by gene ontology.
Esophageal Squamous Cell Carcinoma
Associations of carboxypeptidase 4 with ALDH1A1 expression and their prognostic value in esophageal squamous cell carcinoma.
Essential Hypertension
Circulating Aminopeptidase Activities in Men and Women with Essential Hypertension.
The human angiotensinase C gene (HUMPCP) maps to 11q14 within 700 kb of D11S901: a candidate gene for essential hypertension.
Glioblastoma
Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage.
Glomerulonephritis
Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor.
Granuloma
Immunofluorescent localization of angiotensin converting enzyme in epithelioid and giant cells of sarcoidosis granulomas.
Heart Failure
Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels.
Evidence against a major role for angiotensin converting enzyme-related carboxypeptidase (ACE2) in angiotensin peptide metabolism in the human coronary circulation.
Optimising ACE inhibitor therapy of congestive heart failure. Insights from pharmacodynamic studies.
Hepatitis
Association between expression of Carboxypeptidase 4 and stem cell markers and their clinical significance in liver cancer development.
Hepatitis B
Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme.
gp180, a host cell glycoprotein that binds duck hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family.
Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains.
Hyperalgesia
Thrombomodulin alfa prevents oxaliplatin-induced neuropathic symptoms through activation of thrombin-activatable fibrinolysis inhibitor and protein C without affecting anti-tumor activity.
Hyperlipidemias
Prolyl carboxypeptidase activity decline correlates with severity and short-term outcome in acute ischemic stroke.
Hypersensitivity
Allergy to hedgehog with carboxypeptidase and chitinase-like and chymotrypsin-like elastase family members as the relevant allergens.
Hypertension
Angiotensin carboxypeptidase activity in urine from normal subjects and patients with kidney damage.
Angiotensin-converting enzyme 2 in the brain: properties and future directions.
Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system.
Ebelactone B, an inhibitor of urinary carboxypeptidase Y-like kininase, prevents the development of deoxycorticosterone acetate-salt hypertension in rats.
Effect of prolonged administration of a urinary kinase inhibitor, ebelactone B on the development of deoxycorticosterone acetate-salt hypertension in rats.
Prolyl carboxypeptidase activity decline correlates with severity and short-term outcome in acute ischemic stroke.
Role of the renal kallikrein-kinin system in the development of hypertension.
Role of the renal kallikrein-kinin system in the development of salt-sensitive hypertension.
Hypoglycemia
Reflex splanchnic nerve stimulation increases levels of proenkephalin A mRNA and proenkephalin A-related peptides in the rat adrenal medulla.
Hypogonadism
A New Cause of Obesity Syndrome Associated with a Mutation in Carboxypeptidase (CPE) Gene Detected in Three Siblings with Obesity, Intellectual Disability and Hypogonadotropic Hypogonadism
Infections
Carboxypeptidases B of Anopheles gambiae as targets for a Plasmodium falciparum transmission-blocking vaccine.
Modulation of posterior intestinal mucosal proteome in rainbow trout (Oncorhynchus mykiss) after Yersinia ruckeri infection.
Molecular characterization of carboxypeptidase B-like (CPB) in Scylla paramamosain and its role in white spot syndrome virus and Vibrio alginolyticus infection.
Structure and function of REP34 implicates carboxypeptidase activity in Francisella tularensis host cell invasion.
Thrombin activatable fibrinolysis inhibitor: not just an inhibitor of fibrinolysis.
Infertility, Male
Role of Cytosolic Carboxypeptidase 5 in Neuronal Survival and Spermatogenesis.
Influenza, Human
Characterization of the carboxypeptidase involved in the proteolytic cleavage of the influenza haemagglutinin.
Insulinoma
Carboxypeptidase activity in the insulin secretory granule.
Intellectual Disability
A New Cause of Obesity Syndrome Associated with a Mutation in Carboxypeptidase (CPE) Gene Detected in Three Siblings with Obesity, Intellectual Disability and Hypogonadotropic Hypogonadism
Ischemic Stroke
Prolyl carboxypeptidase activity decline correlates with severity and short-term outcome in acute ischemic stroke.
The decrease in procarboxypeptidase U (TAFI) concentration in acute ischemic stroke correlates with stroke severity, evolution and outcome.
Leptospirosis
Synthesis, Leptospirocidal Activity and QSAR Analysis of Novel Quinoxaline Derivatives.
Liver Cirrhosis
Association between expression of Carboxypeptidase 4 and stem cell markers and their clinical significance in liver cancer development.
Liver Neoplasms
Association between expression of Carboxypeptidase 4 and stem cell markers and their clinical significance in liver cancer development.
Lung Diseases
Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration.
[Angiotensin I converting enzyme and carboxypeptidase B-like enzymes in sarcoidosis and other lung diseases]
Lymphoma
Latexin expression is downregulated in human gastric carcinomas and exhibits tumor suppressor potential.
Resumption of high-dose methotrexate after methotrexate-induced nephrotoxicity and carboxypeptidase G2 use.
Lymphoma, Large-Cell, Anaplastic
Resumption of high-dose methotrexate after methotrexate-induced nephrotoxicity and carboxypeptidase G2 use.
Malaria
Deletion of carboxypeptidase N delays onset of experimental cerebral malaria.
Molecular characterization of the carboxypeptidase B1 of Anopheles stephensi and its evaluation as a target for transmission-blocking vaccines.
Rapid induction by a blood meal of a carboxypeptidase gene in the gut of the mosquito Anopheles gambiae.
Mastocytosis
Mast-cell phenotype in indolent forms of mastocytosis. Ultrastructural features, fluorescence detection of avidin binding, and immunofluorescent determination of chymase, tryptase, and carboxypeptidase.
Melanoma
Lactacystin inhibits cathepsin A activity in melanoma cell lines.
Myocardial Infarction
Carboxypeptidase N and creatine kinase-MB isoforms in acute myocardial infarction.
Characterization of MB creatine kinase isoform conversion in vitro and in vivo in dogs.
Inducible carboxypeptidase activity. A role in clot lysis in vivo.
Neoplasm Metastasis
Expression of RARRES1 and AGBL2 and progression of conventional renal cell carcinoma.
Immunocytochemical detection of amylase, carboxypeptidase A, carcinoembryonic antigen and alpha 1-antitrypsin in carcinomas of the exocrine pancreas of the dog.
New Prostate Cancer Targets for Diagnosis, Imaging, and Therapy: Focus on Prostate-Specific Membrane Antigen.
Targeting prostate-specific membrane antigen for personalized therapies in prostate cancer: morphologic and molecular backgrounds and future promises.
Neoplasms
A new crystal form of carboxypeptidase G2 from Pseudomonas sp. strain RS-16 which is more amenable to structure determination.
An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1.
Carboxypeptidase A6 Promotes the Proliferation and Migration of Hepatocellular Carcinoma by Up-regulating AKT Signaling Pathway.
Carboxypeptidases and carboxypeptidase inhibitor in tumor-bearing animals; a possible blood test for neoplasia.
Cathepsin X Cleaves Profilin 1 C-Terminal Tyr139 and Influences Clathrin-Mediated Endocytosis.
Characterization of cathepsin X in colorectal cancer development and progression.
Clinical evaluation of the blood cell carboxypeptidase inhibitor test for malignant neoplasia.
Conjugated polymer nanoparticles for drug delivery and imaging.
CuInS(2) quantum dots/poly((L)-glutamic acid)-drug conjugates for drug delivery and cell imaging.
Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy.
Expression of Carboxypeptidase X M14 Family Member 2 Accelerates the Progression of Hepatocellular Carcinoma via Regulation of the gp130/JAK2/Stat1 Pathway.
Fat cell-derived modulators of vascular cell pathophysiology: the list keeps growing.
Identification and characterization of the novel reversible and selective cathepsin X inhibitors.
Immunocytochemical detection of amylase, carboxypeptidase A, carcinoembryonic antigen and alpha 1-antitrypsin in carcinomas of the exocrine pancreas of the dog.
Label-Free Quantitative Proteomics Unravels Carboxypeptidases as the Novel Biomarker in Pancreatic Ductal Adenocarcinoma.
Latexin expression is downregulated in human gastric carcinomas and exhibits tumor suppressor potential.
Latexin is down-regulated in hematopoietic malignancies and restoration of expression inhibits lymphoma growth.
Mechanisms Governing Anaphylaxis: Inflammatory Cells, Mediators, Endothelial Gap Junctions and Beyond.
Methanethiol Binding Strengths and Deprotonation Energies in Zn(II)-Imidazole Complexes from M05-2X and MP2 Theories: Coordination Number and Geometry Influences Relevant to Zinc Enzymes.
Molecular modeling approach to predict a binding mode for the complex methotrexate-carboxypeptidase G(2).
Potato carboxypeptidase inhibitor, a T-knot protein, is an epidermal growth factor antagonist that inhibits tumor cell growth.
Profilin 1 as a target for cathepsin X activity in tumor cells.
Prostate-specific membrane antigen directed selective thrombotic infarction of tumors.
Pyrrolidon carboxypeptidase activities in the hypothalamus-pituitary-thyroid and hypothalamus-pituitary-ovary axes of rats with mammary gland cancer induced by N-methyl nitrosourea.
Rapid and Sensitive Detection of Cancer Cells with Activatable Fluorescent Probes for Enzyme Activity.
Secretion and regulation of two biosynthetic enzyme activities, peptidyl-glycine alpha-amidating monooxygenase and a carboxypeptidase, by mouse pituitary corticotropic tumor cells.
Serglycin--structure and biology.
The methotrexate story: a paradigm for development of cancer chemotherapeutic agents.
Treatment of central nervous system tumors with methotrexate.
Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the ?-tubulin tyrosination cycle.
Tumor suppressor RARRES1 links tubulin deglutamylation to mitochondrial metabolism and cell survival.
Neuroblastoma
Renin, angiotensins, and angiotensin-converting enzyme in neuroblastoma cells: evidence for intracellular formation of angiotensins.
Obesity
A New Cause of Obesity Syndrome Associated with a Mutation in Carboxypeptidase (CPE) Gene Detected in Three Siblings with Obesity, Intellectual Disability and Hypogonadotropic Hypogonadism
Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity.
Depressed expression of adipocyte beta-adrenergic receptors is a common feature of congenital and diet-induced obesity in rodents.
Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice.
ONSET OF OBESITY IN CARBOXYPEPTIDASE E-DEFICIENT MICE AND EFFECT ON AIRWAY RESPONSIVENESS AND PULMONARY RESPONSES TO OZONE.
Peptides, enzymes and obesity: new insights from a 'dead' enzyme.
Prolyl carboxypeptidase activity decline correlates with severity and short-term outcome in acute ischemic stroke.
Osteosarcoma
Carboxypeptidase E-?N promotes migration, invasion and epithelial-mesenchymal transition of human osteosarcoma cell lines through the Wnt/?-catenin pathway.
Overexpression of carboxypeptidase X M14 family member 2 predicts an unfavorable prognosis and promotes proliferation and migration of osteosarcoma.
Pancreatic Neoplasms
Carboxypeptidase E-?N Promotes Proliferation and Invasion of Pancreatic Cancer Cells via Upregulation of CXCR2 Gene Expression.
Immunocytochemical detection of amylase, carboxypeptidase A, carcinoembryonic antigen and alpha 1-antitrypsin in carcinomas of the exocrine pancreas of the dog.
Loss of 18q22.3 involving the carboxypeptidase of glutamate-like gene is associated with poor prognosis in resected pancreatic cancer.
Pancreatitis
Radioimmunoassay of active pancreatic enzymes in sera from patients with acute pancreatitis. I. Active carboxypeptidase B.
Trypsin-based laboratory methods and carboxypeptidase activation peptide in acute pancreatitis.
Pancreatitis, Chronic
Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.
Periodontitis
Carboxypeptidase-mediated metabolism of calcitonin gene-related peptide in human gingival crevicular fluid--a rôle in periodontal inflammation?
Pneumonia
Effect of antigen sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient mice.
Prostatic Neoplasms
Bivalent Inhibitors of Prostate-Specific Membrane Antigen Conjugated to Desferrioxamine B Squaramide Labeled with Zirconium-89 or Gallium-68 for Diagnostic Imaging of Prostate Cancer.
Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer.
Fluorescence Detection of Prostate Cancer by an Activatable Fluorescence Probe for PSMA Carboxypeptidase Activity.
Profilin 1 as a target for cathepsin X activity in tumor cells.
Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells.
Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin.
Renal Insufficiency, Chronic
Indoxyl Sulfate Downregulates Mas Receptor via Aryl Hydrocarbon Receptor/Nuclear Factor-kappa B, and Induces Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells.
Respiratory Distress Syndrome
Studies of complement activation in ARDS patients treated by long-term extracorporeal CO2 removal.
Sarcoidosis
Identification of a thermolysin-like metalloendopeptidase in serum: activity in normal subjects and in patients with sarcoidosis.
Immunofluorescent localization of angiotensin converting enzyme in epithelioid and giant cells of sarcoidosis granulomas.
[Angiotensin I converting enzyme and carboxypeptidase B-like enzymes in sarcoidosis and other lung diseases]
Seizures, Febrile
Carboxypeptidase A6 gene (CPA6) mutations in a recessive familial form of febrile seizures and temporal lobe epilepsy and in sporadic temporal lobe epilepsy.
Carboxypeptidase A6 Promotes the Proliferation and Migration of Hepatocellular Carcinoma by Up-regulating AKT Signaling Pathway.
Sepsis
Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions.
Starvation
Characterization of a novel carboxypeptidase produced by the entomopathogenic fungus Metarhizium anisopliae.
Characterization of a vacuolar protease in Neurospora crassa and the use of gene RIPing to generate protease-deficient strains.
Stroke
Serum activity of angiotensin converting enzyme 2 is decreased in patients with acute ischemic stroke.
Stupor
[Effect of chloroform and ether narcosis on the activity of basic carboxypeptidases in the hypothalamic-pituitary-adrenal axis in rats]
Thrombosis
Characterizing the tick carboxypeptidase inhibitor: molecular basis for its two-domain nature.
Deficiency in thrombin-activatable fibrinolysis inhibitor (TAFI) protected mice from ferric chloride-induced vena cava thrombosis.
Inducible carboxypeptidase activity. A role in clot lysis in vivo.
Inhibition of carboxypeptidase U (TAFIa) activity improves rt-PA induced thrombolysis in a dog model of coronary artery thrombosis.
Is exogenous tissue plasminogen activator necessary for antithrombotic efficacy of an inhibitor of thrombin activatable fibrinolysis inhibitor (TAFI) in rats?
Murine model of ferric chloride-induced vena cava thrombosis: evidence for effect of potato carboxypeptidase inhibitor.
Thrombus lysis by uPA, scuPA and tPA is regulated by plasma TAFI.
Tuberculosis
Identification of a novel carboxypeptidase encoded by Rv3627c that plays a potential role in mycobacteria morphology and cell division.
Vaccinia
Yeast KEX1 protease cleaves a prohormone processing intermediate in mammalian cells.
Vascular Diseases
Fat cell-derived modulators of vascular cell pathophysiology: the list keeps growing.
Vascular System Injuries
Fat cell-derived modulators of vascular cell pathophysiology: the list keeps growing.
Virus Diseases
ACE2 and gut amino acid transport.
Wilms Tumor
Molecular signature of human bone marrow-derived mesenchymal stromal cell subsets.