Reference on EC 3.4.14.5 - dipeptidyl-peptidase IV
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hegen, M.; Niedobitek, G.; Klein, C.E.; Stein, H.; Fleischer, B.
The T cell triggering molecule Tp103 is associated with dipeptidyl aminopeptidase IV activity
J. Immunol.
144
2908-2914
1990
Homo sapiens
Khalid, N.M.; Marth, E.H.
Purification and partial characterization of a prolyl-dipeptidyl aminopeptidase from Lactobacillus helveticus CNRZ 32
Appl. Environ. Microbiol.
56
381-388
1990
Lactobacillus helveticus, Lactobacillus helveticus CNRZ 32
Tiruppathi, C.; Miyamoto, Y.; Ganapathy, V.; Roesel, R.A.; Whitford, G.M.; Leibach, F.H.
Hydrolysis and transport of proline-containing peptides in renal brush-border membrane vesicles from dipeptidyl peptidase IV-positive and dipeptidyl peptidase IV-negative rat strains
J. Biol. Chem.
265
1476-1483
1990
Rattus norvegicus
Tsakalidou, E.; Anastasiou, R.; Papadimitriou, K.; Manopoulou, E.; Kalantzopoulos, G.
Purification and characterisation of an intracellular X-prolyl-dipeptidyl aminopeptidase from Streptococus thermophilus ACA-DC 4
J. Biotechnol.
59
203-211
1997
Streptococcus thermophilus, Streptococcus thermophilus ACA-DC 4
Ogata, S.; Misumi, Y.; Ikehara, Y.
Primary structure of rat liver dipeptidyl peptidase IV deduced from its cDNA and identification of the NH2-terminal signal sequence as the membrane-anchoring domain
J. Biol. Chem.
264
3596-3601
1989
Rattus norvegicus
Reuter, W.; Hartel, S.; Hanski, C.; Huhle, T.; Zimmer, T.; Gossrau, R.
Biochemical properties of dipeptidyl peptidase IV in liver and hepatoma plasma membranes
Adv. Enzyme Regul.
28
253-269
1989
Rattus norvegicus
Hong, W.; Piazza, G.A.; Hixson, D.C.; Doyle, D.
Expression of enzymatically active rat dipeptidyl peptidase IV in Chinese hamster ovary cells after transfection
Biochemistry
28
8474-8479
1989
Rattus norvegicus
Piazza, G.A.; Callanan, H.M.; Mowery, J.; Hixson, D.C.
Evidence for a role of dipeptidyl peptidase IV in fibronectin-mediated interactions of hepatocytes with extracellular matrix
Biochem. J.
262
327-334
1989
Rattus norvegicus
Kiefer-Partsch, B.; Bockelmann, W.; Geis, A.; Teuber, M.
Purification of an X-prolyl-dipeptidyl aminopeptidase from the cell wall proteolytic system of Lactococcus lactis subsp. Cremoris
Appl. Microbiol. Biotechnol.
31
75-78
1989
Lactococcus lactis
-
Kikuchi, M.; Fukuyama, K.; Epstein, W.L.
Soluble dipeptidyl peptidase IV from terminal differentiated rat epidermal cells: purification and its activity on synthetic and natural peptides
Arch. Biochem. Biophys.
266
369-376
1988
Rattus norvegicus
Heins, J.; Welker, P.; Schönlein, C.; Born, I.; Hartrodt, B.; Neubert, K.; Tsuru, D.; Barth, A.
Mechanism of proline-specific proteinases: (I) Substrate specificity of dipeptidyl peptidase IV from pig kidney and proline-specific endopeptidase from Flavobacterium meningosepticum
Biochim. Biophys. Acta
954
161-169
1988
Sus scrofa
Yamashita, K.; Tachibana, Y.; Matsuda, Y.; Katunuma, N.; Kochibe, N.; Kobata, A.
Comparative studies of the sugar chains of aminopeptidase N and dipeptidylpeptidase IV purified from rat kidney brush-border membrane
Biochemistry
27
5565-5573
1988
Rattus norvegicus
Bauvois, B.
A collagen-binding glycoprotein on the surface of mouse fibroblasts is identified as dipeptidyl peptidase IV
Biochem. J.
252
723-731
1988
Mus musculus
Hartel, S.; Hanski, C.; Kreisel, W.; Hoffmann, C.; Mauck, J.; Reutter, W.
Rapid purification of dipeptidyl peptidase IV from rat liver plasma membrane
Biochim. Biophys. Acta
924
543-547
1987
Rattus norvegicus
Hanski, C.; Zimmer, T.; Gossrau, R.; Reutter, W.
Increased activity of dipeptidyl peptidase IV in serum of hepatoma-bearing rats coincides with the loss of the enzyme from the hepatoma plasma membrane
Experientia
42
826-828
1986
Rattus norvegicus
Alvarez, N.G.; Bordallo, C.; Gascon, S.; Rendueles, P.S.
Purification and characterization of a thermosensitive X-prolyl dipeptidyl aminopeptidase (dipeptidyl aminopeptidase yscV) from Saccharomyces cerevisiae
Biochim. Biophys. Acta
823
119-125
1985
Saccharomyces cerevisiae
-
Bartles, J.R.; Braiterman, L.T.; Hubbard, A.L.
Biochemical characterization of domain-specific glycoproteins of the rat hepatocyte plasma membrane
J. Biol. Chem.
260
12792-12802
1985
Rattus norvegicus
Caporale, C.; Fontanella, A.; Petrilli, P.; Pucci, P.; Molinaro, M.F.; Picone, D.; Auricchio, S.
Isolation and characterization of dipeptidyl peptidase IV from human meconium. Functional role of beta-casomorphins
FEBS Lett.
184
273-277
1985
Homo sapiens
Gonschor, H.; Schäfer, W.
Dipeptidyl peptidase IV. Purification for use in peptide sequencing
Biol. Chem. Hoppe-Seyler
366
157-165
1985
Sus scrofa
Hanski, C.; Hihle, T.; Reutter, W.
Involvement of plasma membrane dipeptidyl peptidase IV in fibronectin-mediated adhesion of cells on collagen
Biol. Chem. Hoppe-Seyler
366
1169-1176
1985
Mesocricetus auratus
Kudo, M.; Nakamura, T.; Koyama, J.
Purification and some properties of a membrane-bound dipeptidyl peptidase IV of guinea pig casein-induced intraperitoneal leukocytes
J. Biochem.
97
1211-1218
1985
Cavia porcellus
Mentlein, R.; Heymann, E.; Scholz, W.; Feller, A.C.; Flad, H.D.
Dipeptidyl peptidase IV as a new surface marker for a subpopulation of human T-lymphocytes
Cell. Immunol.
89
11-19
1984
Homo sapiens
Schön, E.; Demuth, H.U.; Barth, A.; Ansorge, S.
Dipeptidyl peptidase IV of human lymphocytes. Evidence for specific hydrolysis of glycylproline p-nitroanilide in T-lymphocytes
Biochem. J.
223
255-258
1984
Homo sapiens
Harada, M.; Hiraoka, B.Y.; Fukasawa, K.M.; Fukasawa, K.
Chemical modification of dipeptidyl peptidase iv: involvement of an essential tryptophan residue at the substrate binding site
Arch. Biochem. Biophys.
234
622-628
1984
Sus scrofa
Bordallo, C.; Schwencke, J.; Rendueles, M.S.
Localization of the thermosensitive X-prolyl dipeptidyl aminopeptidase in the vacuolar membrane of Saccharomyces cerevisiae
FEBS Lett.
173
199-203
1984
Saccharomyces cerevisiae
Umezawa, H.; Aoyagi, T.; Ogawa, K.; Naganawa, H.; Hamada, M.; Takeuchi, T.
Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria
J. Antibiot.
37
422-425
1984
Rattus norvegicus
Heins, J.; Neubert, K.; Barth, A.; Canizaro, P.C.; Behal, F.J.
Kinetic investigation of the hydrolysis of aminoacyl p-nitroanilides by dipeptidyl peptidase IV from human and pig kidney
Biochim. Biophys. Acta
785
30-35
1984
Homo sapiens, Rattus norvegicus, Sus scrofa
Miura, S.; Song, I.S.; Morita, A.; Erickson, R.H.; Kim, Y.S.
Distribution and biosynthesis of aminopeptidase N and dipeptidyl aminopeptidase IV in rat small intestine
Biochim. Biophys. Acta
761
66-75
1983
Rattus norvegicus
Saison, M.; Verlinden, J.; van Leuven, F.; Cassiman, J.J.; van den Berghe, H.
Identification of cell surface dipeptidylpeptidase IV in human fibroblasts
Biochem. J.
216
177-183
1983
Homo sapiens
Fukasawa, K.M.; Fukasawa, K.; Hiraoka, B.Y.; Harada, M.
Characterization of a soluble form of dipeptidyl peptidase IV from pig liver
Experientia
39
1005-1007
1983
Sus scrofa
Erickson, R.H.; Bella, A.M.; Brophy, E.J.; Kobata, A.; Kim, Y.S.
Purification and molecular characterization of rat intestinal brush border membrane dipeptidyl aminopeptidase IV
Biochim. Biophys. Acta
756
258-265
1983
Rattus norvegicus
Ichinose, M.; Maeda, R.; Fukuda, T.; Watanabe, B.; Ishimaru, T.; Izumi, M.; Miyake, S.; Takamori, M.
Partial purification and characterization of glycylprolyl dipeptidyl aminopeptidase in porcine pancreas
Biochim. Biophys. Acta
719
527-531
1982
Sus scrofa
Bella, A.M.; Erickson, R.H.; Kim, Y.S.
Rat intestinal brush border membrane dipeptidyl-aminopeptidase IV: kinetic properties and substrate specificities of the purified enzyme
Arch. Biochem. Biophys.
218
156-162
1982
Rattus norvegicus
Püschel, G.; Mentlein, R.; Heymann, E.
Isolation and characterization of dipeptidyl peptidase IV from human placenta
Eur. J. Biochem.
126
359-365
1982
Homo sapiens
Mentlein, R.; Heymann, E.
Dipeptidyl peptidase IV inhibits the polymerization of fibrin monomers
Arch. Biochem. Biophys.
217
748-750
1982
Homo sapiens
Yoshimoto, T.; Kita, T.; Ichinose, M.; Tsuru, D.
Dipeptidyl aminopeptidase IV from porcine pancreas
J. Biochem.
92
275-282
1982
Sus scrofa
Fukasawa, K.M.; Harada, M.
Purification and properties of dipeptidyl peptidase IV from Streptococcus mitis ATCC 9811
Arch. Biochem. Biophys.
210
230-237
1981
Streptococcus mitis
Fukasawa, K.M.; Fukasawa, K.; Hiraoka, B.Y.; Harada, M.
Comparison of dipeptidyl peptidase IV prepared from pig liver and kidney
Biochim. Biophys. Acta
657
179-189
1981
Sus scrofa
Kojima, K.; Hama, T.; Kato, T.; Nagatsu, T.
Rapid chromatographic purification of dipeptidyl peptidase IV in human submaxillary gland
J. Chromatogr.
189
233-240
1980
Homo sapiens
Macnair, R.D.C.; Kenny, A.J.
Proteins of the kidney microvillar membrane. The amphipathic form of dipeptidyl peptidase IV
Biochem. J.
179
379-395
1979
Sus scrofa
Svensson, B.; Danielsen, M.; Staun, M.; Jeppesen, L.; Noren, O.; Sjöström, H.
An amphiphilic form of dipeptidyl peptidase IV from pig small-intestinal brush-border membrane. Purification by immunoadsorbent chromatography and some properties
Eur. J. Biochem.
90
489-498
1978
Sus scrofa
Mineyama, R.; Saito, K.
Purification and characterization of dipeptidyl peptidase IV from Streptococcus salivarius HHT
Microbios
68
37-52
1991
Streptococcus salivarius, Streptococcus salivarius HHT
Shibuya-Saruta, H.; Kasahara, Y.; Hashimoto, Y.
Human serum dipeptidyl peptidase IV (DPPIV) and its unique properties
J. Clin. Lab. Anal.
10
435-440
1996
Homo sapiens
Fukasawa, K.M.; Fukasawa, K.; Harada, M.
Dipeptidyl aminopeptidase IV, a glycoprotein from pig kidney
Biochim. Biophys. Acta
535
161-166
1978
Sus scrofa
Kabashima, T.; Ito, K.; Yoshimoto, T.
Dipeptidyl peptidase IV from Xanthomonas maltophilia: sequencing and expression of the enzyme gene and characterization of the expressed enzyme
J. Biochem.
120
1111-1117
1996
Stenotrophomonas maltophilia
Kenny, A.J.; Booth, A.G.; George, S.G.; Ingram, J.; Kershaw, D.; Wood, E.J.; Young, A.R.
Dipeptidyl peptidase IV, a kidney brush-border serine peptidase
Biochem. J.
155
169-182
1976
Sus scrofa
Hendriks, D.; de Meester, I.; Umiel, T.; Vanhoof, G.; Scharpe, S.; Yaron, A.
Dipeptidy peptidas IV activity in stimulated T lymphocytes
Biochem. Soc. Trans.
16
365-366
1988
Homo sapiens
-
Schön, E.; Jahn, S.; Kiessig, S.T.; Demuth, H.U.; Neubert, K.; Barth, A.; von Baehr, R.; Ansorge, S.
The role of dipeptidyl peptidase IV in human T lymphocyte activation. Inhibitors and antibodies against dipeptidyl peptidase IV suppress lymphocyte proliferation and immunoglobulin synthesis in vitro
Eur. J. Immunol.
17
1821-1826
1987
Homo sapiens
Yan, T.R.; Ho, S.C.; Hou, C.L.
Catalytic properties of X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis subsp. cremoris nTR
Biosci. Biotechnol. Biochem.
56
704-707
1992
Lactococcus lactis
Augustyns, K.; Bal, G.; Thonus, G.; Belyaev, A.; Zhang, X.M.; Bollaert, W.; Lambeir, A.M.; Durinx, C.; Goossens, F.; Haemers, A.
The unique properties of dipeptidyl-peptidase IV (DPP IV / CD26) and the therapeutic potential of DPP IV inhibitors
Curr. Med. Chem.
6
311-327
1999
Homo sapiens, Mammalia
Lambeir, A.M.; Borloo, M.; de Meester, I.; Belyaev, A.; Augustyns, K.; Hendriks, D.; Scharpe, S.; Haemers, A.
Dipeptide-derived diphenyl phosphonate esters: mechanism-based inhibitors of dipeptidyl peptidase IV
Biochim. Biophys. Acta
1290
76-82
1996
Homo sapiens
David, F.; Bernard, A.M.; Pierres, M.; Marguet, D.
Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). A member of a novel family of nonclassical serine hydrolases
J. Biol. Chem.
268
17247-17252
1993
Mus musculus
Chich, J.F.; Rigolet, P.; Nardi, M.; Gripon, J.C.; Ribadeau-Dumas, B.; Brunie, S.
Purification, crystallization, and preliminary X-ray analysis of PepX, an X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis
Proteins Struct. Funct. Genet.
23
278-281
1995
Lactococcus lactis
Habibi-Najafi, M.B.; Lee, B.H.
Purification and characterization of X-prolyl dipeptidyl peptidase from Lactobacillus casei subsp. casei LLG
Appl. Microbiol. Biotechnol.
42
280-286
1994
Lactococcus lactis
Zevaco, C.; Monnet, V.; Gripon, J.C.
Intracellular X-prolyl dipeptidyl peptidase from Lactococcus lactis spp. lactis: purification and properties
J. Appl. Bacteriol.
68
357-366
1990
Lactococcus lactis
-
Lorey, S.; Faust, J.; Herrmanns, U.; Bühling, F.; Ansorge, S.; Neubert, K.
New fluorogenic dipeptidyl peptidase IV/CD26 substrates and inhibitors
Adv. Exp. Med. Biol.
421
157-160
1997
Mammalia
Ohkubo, I.; Huang, K.; Ochiai, Y.; Takagaki, M.; Kani, K.
Dipeptidyl peptidase IV from porcine seminal plasma: purification, characterization, and N-terminal amino acid sequence
J. Biochem.
116
1182-1186
1994
Sus scrofa
Iwaki-Egawa, S.; Watanabe, Y.; Kikuya, Y.; Fujimoto, Y.
Dipeptidyl peptidase IV from human serum: purification, characterization, and N-terminal amino acid sequence
J. Biochem.
124
428-433
1998
Homo sapiens
Miyakawa, H.; Hashimoto, I.; Nakamura, T.; Ishibashi, N.; Shimamura, S.; Igoshi, K.
Purification and characterization of an X-prolyl dipeptidyl aminopeptidase from Lactobacillus helveticus LHE-511
Milchwissenschaft
49
670-673
1994
Lactobacillus helveticus, Lactobacillus helveticus LHE-511
-
De Meester, I.; Vanhoof, G.; Hendriks, D.; Demuth, H.U.; Yaron, A.; Scharpe, S.
Characterization of dipeptidyl peptidase IV (CD26) from human lymphocytes
Clin. Chim. Acta
210
23-24
1992
Homo sapiens
Brownlees, J.; Williams, C.H.; Brennan, G.P.; Halton, D.W.
Purification and immunochemical studies of dipeptidyl peptidase IV from bovine kidney
Biol. Chem. Hoppe-Seyler
373
911-914
1992
Bos taurus
Misumi, Y.; Hayashi, Y.; Arakawa, F.; Ikehara, Y.
Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface
Biochim. Biophys. Acta
1131
333-336
1992
Homo sapiens
Kyouden, T.; Himeno, M.; Ishikawa, T.; Ohsumi, Y.; Kato, K.
Purification and characterization of dipeptidyl peptidase IV in rat liver lysosomal membranes
J. Biochem.
111
770-777
1992
Rattus norvegicus
Ramos, C.G.; Camarillo, R.C.; Gascon, S.; Rendueles, M.P.S.
Studies on the regulation of X-prolyl dipeptidyl aminopeptidase activity
J. Gen. Microbiol.
129
3519-3523
1983
Saccharomyces cerevisiae
Schön, E.; Born, I.; Demuth, H.U.; Faust, J.; Neubert, K.; Steinmetzer, T.; Barth, A.; Ansorge, S.
Dipeptidyl peptidase IV in the immune system. Effects of specific enzyme inhibitors on activity of dipeptidyl peptidase IV and proliferation of human lymphocytes
Biol. Chem. Hoppe-Seyler
372
305-311
1991
Homo sapiens
Chikuma, T.; Hama, T.; Nagatsu, T.; Kumegawa, M.; Kato, T.
Purification and properties of dipeptidyl peptidase IV from human urine
Biol. Chem. Hoppe-Seyler
371
325-330
1990
Homo sapiens
Lloyd, R.J.; Pritchard, G.G
Characterization of X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis subsp. Lactis
J. Gen. Microbiol.
137
49-55
1991
Lactococcus lactis
-
Volk, B.A.; Kreisel, W.; Köttgen, E.; Gerok, W.; Reutter, W.
Heterogeneous turnover of terminal and core sugars within the carbohydrate chain of dipeptidylaminopeptidase IV isolated from rat liver plasma membrane
FEBS Lett.
163
150-152
1983
Rattus norvegicus
Ikehara, Y.; Ogata, S.; Misumi, Y.
Dipeptidyl-peptidase IV from rat liver
Methods Enzymol.
244
215-227
1994
Rattus norvegicus
Rigolet, P.; Mechin, I.; Delage, M.M.; Chich, J.F.
The structural basis for catalysis and specificity of the X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis
Structure
10
1383-1394
2002
Lactococcus lactis (P22346), Lactococcus lactis (Q9CE11), Lactococcus lactis
Oefner, C.; D'Arcy, A.; Mac Sweeney, A.; Pierau, S.; Gardiner, R.; Dale, G.E.
High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrol idine
Acta Crystallogr. Sect. D
59
1206-1212
2003
Homo sapiens
Hiramatsu, H.; Kyono, K.; Shima, H.; Fukushima, C.; Sugiyama, S.; Inaka, K.; Yamamoto, A.; Shimizu, R.
Crystallization and preliminary X-ray study of human dipeptidyl peptidase IV (DPPIV)
Acta Crystallogr. Sect. D
59
595-596
2003
Homo sapiens (P27487), Homo sapiens
Lorey, S.; Faust, J.; Buhling, F.; Ansorge, S.; Neubert, K.
A new type of fluorogenic substrates for determination of cellular dipeptidyl peptidase IV (DP IV/CD26) activity
Adv. Exp. Med. Biol.
477
111-115
2000
Sus scrofa
Stockel-Maschek, A.; Stiebitz, B.; Born, I.; Faust, J.; Mogelin, W.; Neubert, K.
Potent inhibitors of dipeptidyl peptidase IV and their mechanisms of inhibition
Adv. Exp. Med. Biol.
477
117-123
2000
Sus scrofa
Mrestani-Klaus, C.; Fengler, A.; Faust, J.; Brandt, W.; Wrenger, S.; Reinhold, D.; Ansorge, S.; Neubert, K.
N-terminal HIV-1 Tat nonapeptides as inhibitors of dipeptidyl peptidase IV. Conformational characterization
Adv. Exp. Med. Biol.
477
125-129
2000
Homo sapiens
Kaehne, T.; Reinhold, D.; Neubert, K.; Born, I.; Faust, J.; Ansorge, S.
Signal transduction events induced or affected by inhibition of the catalytic activity of dipeptidyl peptidase IV (DP IV, CD26)
Adv. Exp. Med. Biol.
477
131-137
2000
Homo sapiens
Brandt, W.
Development of a tertiary-structure model of the C-terminal domain of DPP IV
Adv. Exp. Med. Biol.
477
97-101
2000
Homo sapiens
Baer, J.W.; Gerhartz, B.; Hoffmann, T.; Rosche, F.; Demuth, H.U.
Characterisation of human DP IV produced by a Pichia pastoris expression system
Adv. Exp. Med. Biol.
524
103-108
2003
Homo sapiens
Faust, J.; Fuchs, P.; Wrenger, S.; Reinhold, D.; Stoeckel-Maschek, A.; Kaehne, T.; Ansorge, S.; Neubert, K.
Dipeptidyl peptidase IV inhibitors with the N-terminal MXP sequence: structure-activity-relationships
Adv. Exp. Med. Biol.
524
175-179
2003
Sus scrofa
Lambeir, A.M.; Rea, D.; Fulop, V.; Kumagai, Y.; Augustyns, K.; De Meester, I.; Haemers, A.; Scharpe, S.
Exploration of the active site of dipeptidyl peptidase IV from Porphyromonas gingivalis: comparison with the human enzyme
Adv. Exp. Med. Biol.
524
29-35
2003
Porphyromonas gingivalis, Homo sapiens
Kuehn-Wache, K.; Hoffmann, T.; Manhart, S.; Brandt, W.; Demuth, H.U.
The specificity of DP IV for natural substrates is peptide structure determined
Adv. Exp. Med. Biol.
524
57-63
2003
Homo sapiens
Stoeckel-Maschek, A.; Stiebitz, B.; Faust, J.; Born, I.; Kaehne, T.; Gorrell, M.D.; Neubert, K.
Different inhibition mechanisms of dipeptidyl peptidase IV by tryptophan containing peptides and amides
Adv. Exp. Med. Biol.
524
69-72
2003
Homo sapiens, Sus scrofa
Malik, R.; Busek, P.; Mares, V.; Sevcik, J.; Kleibl, Z.; Sedo, A.
Dipeptidyl peptidase-IV activity and/or structure homologues (DASH) in transformed neuroectodermal cells
Adv. Exp. Med. Biol.
524
95-102
2003
Homo sapiens
Hiramatsu, H.; Kyono, K.; Higashiyama, Y.; Fukushima, C.; Shima, H.; Sugiyama, S.; Inaka, K.; Yamamoto, A.; Shimizu, R.
The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold
Biochem. Biophys. Res. Commun.
302
849-854
2003
Homo sapiens
Pala, L.; Mannucci, E.; Pezzatini, A.; Ciani, S.; Sardi, J.; Raimondi, L.; Ognibene, A.; Cappadona, A.; Vannelli, B.G.; Rotella, C.M.
Dipeptidyl peptidase-IV expression and activity in human glomerular endothelial cells
Biochem. Biophys. Res. Commun.
310
28-31
2003
Homo sapiens
Leiting, B.; Pryor, K.D.; Wu, J.K.; Marsilio, F.; Patel, R.A.; Craik, C.S.; Ellman, J.A.; Cummings, R.T.; Thornberry, N.A.
Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII
Biochem. J.
371
525-532
2003
Homo sapiens
Cohen, M.; Fruitier-Arnaudin, I.; Piot, J.M.
Hemorphins: substrates and/or inhibitors of dipeptidyl peptidase IV. Hemorphins N-terminus sequence influence on the interaction between hemorphins and DPPIV
Biochimie
86
31-37
2004
Rattus norvegicus
Rosenblum, J.S.; Kozarich, J.W.
Prolyl peptidases: a serine protease subfamily with high potential for drug discovery
Curr. Opin. Chem. Biol.
7
496-504
2003
Homo sapiens, Mammalia, Mus musculus, Rattus norvegicus, Sus scrofa
Dobers, J.; Grams, S.; Reutter, W.; Fan, H.
Roles of cysteines in rat dipeptidyl peptidase IV/CD26 in processing and proteolytic activity
Eur. J. Biochem.
267
5093-5100
2000
no activity in Cricetulus griseus, Rattus norvegicus (P14740)
Durinx, C.; Lambeir, A.M.; Bosmans, E.; Falmagne, J.B.; Berghmans, R.; Haemers, A.; Scharpe, S.; De Meester, I.
Molecular characterization of dipeptidyl peptidase activity in serum. Soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides
Eur. J. Biochem.
267
5608-5613
2000
Homo sapiens (P27487), Homo sapiens
Lorey, S.; Stockel-Maschek, A.; Faust, J.; Brandt, W.; Stiebitz, B.; Gorrell, M.D.; Kahne, T.; Mrestani-Klaus, C.; Wrenger, S.; Reinhold, D.; Ansorge, S.; Neubert, K.
Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites
Eur. J. Biochem.
270
2147-2156
2003
Homo sapiens
Kumagai, Y.; Konishi, K.; Gomi, T.; Yagishita, H.; Yajima, A.; Yoshikawa, M.
Enzymatic properties of dipeptidyl aminopeptidase IV produced by the periodontal pathogen Porphyromonas gingivalis and its participation in virulence
Infect. Immun.
68
716-724
2000
Porphyromonas gingivalis (O66223), Porphyromonas gingivalis
Ihara, T.; Tsujikawa, T.; Fujiyama, Y.; Ueyama, H.; Bamba, T.; Ohkubo, I.
Enhancement of brush border peptidase activity in rat jejunum during starvation
Int. Congr. Ser.
1218
389-393
2001
Rattus norvegicus
-
Ryo, M.
Some properties of bacterial dipeptidyl peptidase IV
Int. Congr. Ser.
1218
395-399
2001
Streptococcus salivarius
-
Busek, P.; Malik, R.; Sedo, A.
Dipeptidyl peptidase IV activity and/or structure homologues (DASH) and their substrates in cancer
Int. J. Biochem. Cell Biol.
36
408-421
2004
Homo sapiens
Lorey, S.; Faust, J.; Mrestani-Klaus, C.; Kaehne, T.; Ansorge, S.; Neubert, K.; Buehling, F.
Transcellular proteolysis demonstrated by novel cell surface-associated substrates of dipeptidyl peptidase IV (CD26)
J. Biol. Chem.
277
33170-33177
2002
Sus scrofa
Zhu, L.; Tamvakopoulos, C.; Xie, D.; Dragovic, J.; Shen, X.; Fenyk-Melody, J.E.; Schmidt, K.; Bagchi, A.; Griffin, P.R.; Thornberry, N.A.; Sinha Roy, R.
The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: in vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38)
J. Biol. Chem.
278
22418-22423
2003
Mus musculus
Rasmussen, H.B.; Branner, S.; Wiberg, F.C.; Wagtmann, N.
Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog
Nat. Struct. Biol.
10
19-25
2003
Homo sapiens (P27487), Homo sapiens
Davy, A.; Thomsen, K.K.; Juliano, M.A.; Alves, L.C.; Svendsen, I.; Simpson, D.J.
Purification and characterization of barley dipeptidyl peptidase IV
Plant Physiol.
122
425-432
2000
Hordeum vulgare
Engel, M.; Hoffmann, T.; Wagner, L.; Wermann, M.; Heiser, U.; Kiefersauer, R.; Huber, R.; Bode, W.; Demuth, H.U.; Brandstetter, H.
The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism
Proc. Natl. Acad. Sci. USA
100
5063-5068
2003
Sus scrofa (P22411), Sus scrofa
Aertgeerts, K.; Ye, S.; Shi, L.; Prasad, S.G.; Witmer, D.; Chi, E.; Sang, B.C.; Wijnands, R.A.; Webb, D.R.; Swanson, R.V.
N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding
Protein Sci.
13
145-154
2004
Homo sapiens
Aertgeerts, K.; Ye, S.; Tennant, M.G.; Kraus, M.L.; Rogers, J.; Sang, B.C.; Skene, R.J.; Webb, D.R.; Prasad, G.S.
Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation
Protein Sci.
13
412-421
2004
Homo sapiens
Thoma, R.; Loffler, B.; Stihle, M.; Huber, W.; Ruf, A.; Hennig, M.
Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV
Structure
11
947-959
2003
Homo sapiens (P27487), Homo sapiens
Rea, D.; Lambeir, A.M.; Kumagai, Y.; De Meester, I.; Scharpe, S.; Fueloep, V.
Expression, purification and preliminary crystallographic analysis of dipeptidyl peptidase IV from Porphyromonas gingivalis
Acta Crystallogr. Sect. D
D60
1871-1873
2004
Porphyromonas gingivalis
Guieu, R.; Fenouillet, E.; Devaux, C.; Fajloun, Z.; Carrega, L.; Sabatier, J.M.; Sauze, N.; Marguet, D.
CD26 modulates nociception in mice via its dipeptidyl-peptidase IV activity
Behav. Brain Res.
166
230-235
2006
Mus musculus
Gilmore, B.F.; Carson, L.; McShane, L.L.; Quinn, D.; Coulter, W.A.; Walker, B.
Synthesis, kinetic evaluation, and utilization of a biotinylated dipeptide proline diphenyl phosphonate for the disclosure of dipeptidyl peptidase IV-like serine proteases
Biochem. Biophys. Res. Commun.
347
373-379
2006
Sus scrofa
Longenecker, K.L.; Stewart, K.D.; Madar, D.J.; Jakob, C.G.; Fry, E.H.; Wilk, S.; Lin, C.W.; Ballaron, S.J.; Stashko, M.A.; Lubben, T.H.; Yong, H.; Pireh, D.; Pei, Z.; Basha, F.; Wiedeman, P.E.; von Geldern, T.W.; Trevillyan, J.M.; Stoll, V.S.
Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors
Biochemistry
45
7474-7482
2006
Homo sapiens, Rattus norvegicus (P14740)
Hiramatsu, H.; Yamamoto, A.; Kyono, K.; Higashiyama, Y.; Fukushima, C.; Shima, H.; Sugiyama, S.; Inaka, K.; Shimizu, R.
The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A
Biol. Chem.
385
561-564
2004
Homo sapiens
Abe, M.; Akiyama, T.; Umezawa, Y.; Yamamoto, K.; Nagai, M.; Yamazaki, H.; Ichikawa, Y.; Muraoka, Y.
Synthesis and biological activity of sulphostin analogues, novel dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem.
13
785-797
2005
Rattus norvegicus
Sakashita, H.; Akahoshi, F.; Kitajima, H.; Tsutsumiuchi, R.; Hayashi, Y.
[(S)-gamma-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors
Bioorg. Med. Chem.
14
3662-3671
2006
Homo sapiens, Rattus norvegicus
Brandt, I.; Lambeir, A.M.; Ketelslegers, J.M.; Vanderheyden, M.; Scharpe, S.; De Meester, I.
Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro form
Clin. Chem.
52
82-87
2006
Homo sapiens
Owaga, Y.; Mamura, Y.; Murayama, N.; Yanoshita, R.
Characterization and cDNA cloning of dipeptidyl peptidase IV from the venom of Gloydius blomhoffi brevicaudatus
Comp. Biochem. Physiol. B
145
35-42
2006
Gloydius brevicaudus (Q75S82), Gloydius brevicaudus (Q75S83), Gloydius brevicaudus
Mittal, A.; Khurana, S.; Singh, H.; Kamboj, R.C.
Characterization of dipeptidylpeptidase IV (DPP IV) immobilized in Ca alginate beads
Enzyme Microb. Technol.
37
318-323
2005
Capra hircus
-
Fujimura, S.; Shibata, Y.; Hirai, K.; Ueda, O.
Dipeptidyl peptidase IV of Streptococcus anginosus: purification and characterization
Eur. J. Med. Res.
10
278-282
2005
Streptococcus anginosus
Kim, K.R.; Rhee, S.D.; Kim, H.Y.; Jung, W.H.; Yang, S.D.; Kim, S.S.; Ahn, J.H.; Cheon, H.G.
KR-62436, 6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile, is a novel dipeptidyl peptidase-IV (DPP-IV) inhibitor with anti-hyperglycemic activity
Eur. J. Pharmacol.
518
63-70
2005
Homo sapiens, Rattus norvegicus, Sus scrofa
Bilodeau, N.; Fiset, A.; Poirier, G.G.; Fortier, S.; Gingras, M.C.; Lavoie, J.N.; Faure, R.L.
Insulin-dependent phosphorylation of DPP IV in liver. Evidence for a role of compartmentalized c-Src
FEBS J.
273
992-1003
2006
Rattus norvegicus (P14740)
Cejkova, J.; Zvarova, Z.; Cejka, C.
Dipeptidyl peptidase IV (DPPIV) activity in the tear fluid as an indicator of the severity of corneal injury: a histochemical and biochemical study
Histol. Histopathol.
19
669-676
2004
Oryctolagus cuniculus
Balzarini, J.; Andersson, E.; Schols, D.; Proost, P.; Van Damme, J.; Svennerholm, B.; Horal, P.; Vahlne, A.
Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2))
Int. J. Biochem. Cell Biol.
36
1848-1859
2004
Homo sapiens
Deacon, C.F.; Holst, J.J.
Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetes
Int. J. Biochem. Cell Biol.
38
831-844
2006
Homo sapiens
Jobin, M.C.; Martinez, G.; Motard, J.; Gottschalk, M.; Grenier, D.
Cloning, purification, and enzymatic properties of dipeptidyl peptidase IV from the swine pathogen Streptococcus suis
J. Bacteriol.
187
795-799
2005
Streptococcus suis (Q673U2), Streptococcus suis
Bjelke, J.R.; Christensen, J.; Branner, S.; Wagtmann, N.; Olsen, C.; Kanstrup, A.B.; Rasmussen, H.B.
Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV
J. Biol. Chem.
279
34691-34697
2004
Homo sapiens (P27487), Homo sapiens
Weihofen, W.A.; Liu, J.; Reutter, W.; Saenger, W.; Fan, H.
Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface
J. Biol. Chem.
279
43330-43335
2004
Homo sapiens (P27487), Homo sapiens
Chihara, C.J.; Song, C.; LaMonte, G.; Fetalvero, K.; Hinchman, K.; Phan, H.; Pineda, M.; Robinson, K.; Schneider, G.P.
Identification and partial characterization of the enzyme of omega: one of five putative DPP IV genes in Drosophila melanogaster
J. Insect Sci.
5
26
2005
Drosophila melanogaster
Pei, Z.; Li, X.; Longenecker, K.; von Geldern, T.W.; Wiedeman, P.E.; Lubben, T.H.; Zinker, B.A.; Stewart, K.; Ballaron, S.J.; Stashko, M.A.; Mika, A.K.; Beno, D.W.; Long, M.; Wells, H.; Kempf-Grote, A.J.; Madar, D.J.; McDermott, T.S.; Bhagavatula, L.; Fickes, M.G.; Pireh, D.; Solomon, L.R.; Lake, M.R.; Edalji, R.; Fry, E.H.; Sham, H.L.; Trevillyan, J.M.
Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors
J. Med. Chem.
49
3520-3535
2006
Homo sapiens (P27487)
Edmondson, S.D.; Mastracchio, A.; Mathvink, R.J.; He, J.; Harper, B.; Park, Y.J.; Beconi, M.; Di Salvo, J.; Eiermann, G.J.; He, H.; Leiting, B.; Leone, J.F.; Levorse, D.A.; Lyons, K.; Patel, R.A.; Patel, S.B.; Petrov, A.; Scapin, G.; Shang, J.; Roy, R.S.; Smith, A.; Wu, J.K.; Xu, S.; Zhu, B.; Thornberry, N.A.; Weber, A.E.
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
J. Med. Chem.
49
3614-3627
2006
Mus musculus
Engel, M.; Hoffmann, T.; Manhart, S.; Heiser, U.; Chambre, S.; Huber, R.; Demuth, H.U.; Bode, W.
Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV
J. Mol. Biol.
355
768-783
2006
Sus scrofa (P22411), Sus scrofa
Jalving, R.; Godefrooij, J.; Veen, W.J.; van Ooyen, A.J.; Schaap, P.J.
Characterisation of the Aspergillus niger dapB gene, which encodes a novel fungal type IV dipeptidyl aminopeptidase
Mol. Genet. Genomics
273
319-325
2005
Aspergillus niger (Q96VT7), Aspergillus niger
Ogasawara, W.; Tanaka, C.; Suzuki, M.; Kobayashi, G.; Ogawa, Y.; Okada, H.; Morikawa, Y.
Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24: role of the signal sequence and overexpression in Escherichia coli
Protein Expr. Purif.
41
241-251
2005
Pseudomonas sp. (Q6F3I7), Pseudomonas sp., Pseudomonas sp. WO24 (Q6F3I7)
Sharoyan, S.; Antonyan, A.; Mardanyan, S.; Lupidi, G.; Cristalli, G.
Influence of dipeptidyl peptidase IV on enzymatic properties of adenosine deaminase
Acta Biochim. Pol.
53
539-546
2006
Homo sapiens
Hiramatsu, H.; Kyono, K.; Yamamoto, A.; Saeki, K.; Shima, H.; Sugiyama, S.; Inaka, K.; Shimizu, R.
Crystal structures of human dipeptidyl peptidase IV in its apo and diprotin B-complexed forms
Acta Biochim. Biophys. Sin.
39
335-343
2007
Homo sapiens
Oefner, C.; Pierau, S.; Schulz, H.; Dale, G.E.
Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV
Acta Crystallogr. Sect. D
63
975-981
2007
Homo sapiens
Girardi, A.C.; Fukuda, L.E.; Rossoni, L.V.; Malnic, G.; Reboucas, N.A.
Dipeptidyl peptidase IV inhibition downregulates Na+ - H+ exchanger NHE3 in rat renal proximal tubule
Am. J. Physiol. Renal Physiol.
294
F414-F422
2008
Rattus norvegicus
Reinhold, D.; Biton, A.; Goihl, A.; Pieper, S.; Lendeckel, U.; Faust, J.; Neubert, K.; Bank, U.; Taeger, M.; Ansorge, S.; Brocke, S.
Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses
Ann. N. Y. Acad. Sci.
1110
402-409
2007
Homo sapiens
Miller, S.; St Onge, E.L.
Sitagliptin: a dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Ann. Pharmacother.
40
1336-1343
2006
Homo sapiens
Campbell, R.K.
Rationale for dipeptidyl peptidase 4 inhibitors: a new class of oral agents for the treatment of type 2 diabetes mellitus
Ann. Pharmacother.
41
51-60
2007
Homo sapiens
Ahren, B.
DPP-4 inhibitors
Best Pract. Res. Clin. Endocrinol. Metab.
21
517-533
2007
Homo sapiens
Chien, C.; Tsai, C.; Lin, C.; Chou, C.; Chen, X.
Identification of hydrophobic residues critical for DPP-IV dimerization
Biochemistry
45
7006-7012
2006
Homo sapiens (P27487)
Kondo, T.; Nekado, T.; Sugimoto, I.; Ochi, K.; Takai, S.; Kinoshita, A.; Tajima, Y.; Yamamoto, S.; Kawabata, K.; Nakai, H.; Toda, M.
Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration
Bioorg. Med. Chem.
15
2631-2650
2007
Homo sapiens, Rattus norvegicus
Kondo, T.; Sugimoto, I.; Nekado, T.; Ochi, K.; Ohtani, T.; Tajima, Y.; Yamamoto, S.; Kawabata, K.; Nakai, H.; Toda, M.
Design and synthesis of long-acting inhibitors of dipeptidyl peptidase IV
Bioorg. Med. Chem.
15
2715-2735
2007
Homo sapiens, Rattus norvegicus
Sakashita, H.; Akahoshi, F.; Yoshida, T.; Kitajima, H.; Hayashi, Y.; Ishii, S.; Takashina, Y.; Tsutsumiuchi, R.; Ono, S.
Lead optimization of [(S)-gamma-(arylamino)prolyl]thiazolidine focused on gamma-substituent: Indoline compounds as potent DPP-IV inhibitors
Bioorg. Med. Chem.
15
641-655
2007
Rattus norvegicus, Homo sapiens (P27487)
Kondo, T.; Nekado, T.; Sugimoto, I.; Ochi, K.; Takai, S.; Kinoshita, A.; Hatayama, A.; Yamamoto, S.; Kawabata, K.; Nakai, H.; Toda, M.
Discovery of long-acting N-(cyanomethyl)-N-alkyl-L-prolinamide inhibitors of dipeptidyl peptidase IV
Bioorg. Med. Chem.
16
190-208
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Fukushima, H.; Hiratate, A.; Takahashi, M.; Mikami, A.; Saito-Hori, M.; Munetomo, E.; Kitano, K.; Chonan, S.; Saito, H.; Suzuki, A.; Takaoka, Y.; Yamamoto, K.
Synthesis and structure-activity relationships of potent 4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem.
16
4093-4106
2008
Homo sapiens
Magnin, D.R.; Taunk, P.C.; Robertson, J.G.; Wang, A.; Marcinkeviciene, J.; Kirby, M.S.; Hamann, L.G.
Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1
Bioorg. Med. Chem. Lett.
16
1731-1734
2006
Homo sapiens
Tsai, T.Y.; Coumar, M.S.; Hsu, T.; Hsieh, H.P.; Chien, C.H.; Chen, C.T.; Chang, C.N.; Lo, Y.K.; Wu, S.H.; Huang, C.Y.; Huang, Y.W.; Wang, M.H.; Wu, H.Y.; Lee, H.J.; Chen, X.; Chao, Y.S.; Jiaang, W.T.
Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
16
3268-3272
2006
Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar
Kurukulasuriya, R.; Rohde, J.J.; Szczepankiewicz, B.G.; Basha, F.; Lai, C.; Jae, H.S.; Winn, M.; Stewart, K.D.; Longenecker, K.L.; Lubben, T.W.; Ballaron, S.J.; Sham, H.L.; von Geldern, T.W.
Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
16
6226-6230
2006
Homo sapiens, Rattus norvegicus (P14740)
Coumar, M.S.; Chang, C.N.; Chen, C.T.; Chen, X.; Chien, C.H.; Tsai, T.Y.; Cheng, J.H.; Wu, H.Y.; Han, C.H.; Wu, S.H.; Huang, Y.W.; Hsu, T.; Hsu, L.J.; Chao, Y.S.; Hsieh, H.P.; Jiaang, W.T.
3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes
Bioorg. Med. Chem. Lett.
17
1274-1279
2007
Rattus norvegicus
Tran, T.; Quan, C.; Edosada, C.Y.; Mayeda, M.; Wiesmann, C.; Sutherlin, D.; Wolf, B.B.
Synthesis and structure-activity relationship of N-acyl-Gly-, N-acyl-Sar- and N-blocked-boroPro inhibitors of FAP, DPP4, and POP
Bioorg. Med. Chem. Lett.
17
1438-1442
2007
Homo sapiens
Sheehan, S.M.; Mest, H.J.; Watson, B.M.; Klimkowski, V.J.; Timm, D.E.; Cauvin, A.; Parsons, S.H.; Shi, Q.; Canada, E.J.; Wiley, M.R.; Ruehter, G.; Evers, B.; Petersen, S.; Blaszczak, L.C.; Pulley, S.R.; Margolis, B.J.; Wishart, G.N.; Renson, B.; Hankotius, D.; Mohr, M.; Zechel, J.C.; Michael Kalbfleisch, J.
Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site
Bioorg. Med. Chem. Lett.
17
1765-1768
2007
Homo sapiens (P27487)
Liang, G.B.; Qian, X.; Feng, D.; Biftu, T.; Eiermann, G.; He, H.; Leiting, B.; Lyons, K.; Petrov, A.; Sinha-Roy, R.; Zhang, B.; Wu, J.; Zhang, X.; Thornberry, N.A.; Weber, A.E.
Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes
Bioorg. Med. Chem. Lett.
17
1903-1907
2007
Homo sapiens
Backes, B.J.; Longenecker, K.; Hamilton, G.L.; Stewart, K.; Lai, C.; Kopecka, H.; von Geldern, T.W.; Madar, D.J.; Pei, Z.; Lubben, T.H.; Zinker, B.A.; Tian, Z.; Ballaron, S.J.; Stashko, M.A.; Mika, A.K.; Beno, D.W.; Kempf-Grote, A.J.; Black-Schaefer, C.; Sham, H.L.; Trevillyan, J.M.
Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit
Bioorg. Med. Chem. Lett.
17
2005-2012
2007
Rattus norvegicus (P14740), Homo sapiens (P27487)
Yoshida, T.; Sakashita, H.; Akahoshi, F.; Hayashi, Y.
[(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors
Bioorg. Med. Chem. Lett.
17
2618-2621
2007
Homo sapiens, Rattus norvegicus
Ahn, J.H.; Shin, M.S.; Jun, M.A.; Jung, S.H.; Kang, S.K.; Kim, K.R.; Rhee, S.D.; Kang, N.S.; Kim, S.Y.; Sohn, S.K.; Kim, S.G.; Jin, M.S.; Lee, J.O.; Cheon, H.G.; Kim, S.S.
Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors
Bioorg. Med. Chem. Lett.
17
2622-2628
2007
Homo sapiens
Duffy, J.L.; Kirk, B.A.; Wang, L.; Eiermann, G.J.; He, H.; Leiting, B.; Lyons, K.A.; Patel, R.A.; Patel, S.B.; Petrov, A.; Scapin, G.; Wu, J.K.; Thornberry, N.A.; Weber, A.E.
4-Aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV
Bioorg. Med. Chem. Lett.
17
2879-2885
2007
Homo sapiens (P27487)
Luebbers, T.; Boehringer, M.; Gobbi, L.; Hennig, M.; Hunziker, D.; Kuhn, B.; Loeffler, B.; Mattei, P.; Narquizian, R.; Peters, J.U.; Ruff, Y.; Wessel, H.P.; Wyss, P.
1,3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
17
2966-2970
2007
Homo sapiens
Kim, D.; Kowalchick, J.E.; Edmondson, S.D.; Mastracchio, A.; Xu, J.; Eiermann, G.J.; Leiting, B.; Wu, J.K.; Pryor, K.D.; Patel, R.A.; He, H.; Lyons, K.A.; Thornberry, N.A.; Weber, A.E.
Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: close analogs of JANUVIA (sitagliptin phosphate)
Bioorg. Med. Chem. Lett.
17
3373-3377
2007
Rattus norvegicus
Biftu, T.; Scapin, G.; Singh, S.; Feng, D.; Becker, J.W.; Eiermann, G.; He, H.; Lyons, K.; Patel, S.; Petrov, A.; Sinha-Roy, R.; Zhang, B.; Wu, J.; Zhang, X.; Doss, G.A.; Thornberry, N.A.; Weber, A.E.
Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin
Bioorg. Med. Chem. Lett.
17
3384-3387
2007
Canis lupus familiaris, Macaca mulatta, Rattus norvegicus
Kang, N.S.; Ahn, J.H.; Kim, S.S.; Chae, C.H.; Yoo, S.E.
Docking-based 3D-QSAR study for selectivity of DPP4, DPP8, and DPP9 inhibitors
Bioorg. Med. Chem. Lett.
17
3716-3721
2007
Homo sapiens (P27487)
Gao, Y.D.; Feng, D.; Sheridan, R.P.; Scapin, G.; Patel, S.B.; Wu, J.K.; Zhang, X.; Sinha-Roy, R.; Thornberry, N.A.; Weber, A.E.; Biftu, T.
Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors
Bioorg. Med. Chem. Lett.
17
3877-3879
2007
Homo sapiens (P27487)
Koo, K.D.; Kim, M.J.; Kim, S.; Kim, K.H.; Hong, S.Y.; Hur, G.C.; Yim, H.J.; Kim, G.T.; Han, H.O.; Kwon, O.H.; Kwon, T.S.; Koh, J.S.; Lee, C.S.
Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: oxadiazolyl ketones
Bioorg. Med. Chem. Lett.
17
4167-4172
2007
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
Cox, J.M.; Harper, B.; Mastracchio, A.; Leiting, B.; Sinha Roy, R.; Patel, R.A.; Wu, J.K.; Lyons, K.A.; He, H.; Xu, S.; Zhu, B.; Thornberry, N.A.; Weber, A.E.; Edmondson, S.D.
Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
17
4579-4583
2007
Homo sapiens
Biftu, T.; Feng, D.; Qian, X.; Liang, G.B.; Kieczykowski, G.; Eiermann, G.; He, H.; Leiting, B.; Lyons, K.; Petrov, A.; Sinha-Roy, R.; Zhang, B.; Scapin, G.; Patel, S.; Gao, Y.D.; Singh, S.; Wu, J.; Zhang, X.; Thornberry, N.A.; Weber, A.E.
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorg. Med. Chem. Lett.
17
49-52
2007
Canis lupus familiaris, Mus musculus, Rattus norvegicus
Wright, S.W.; Ammirati, M.J.; Andrews, K.M.; Brodeur, A.M.; Danley, D.E.; Doran, S.D.; Lillquist, J.S.; Liu, S.; McClure, L.D.; McPherson, R.K.; Olson, T.V.; Orena, S.J.; Parker, J.C.; Rocke, B.N.; Soeller, W.C.; Soglia, C.B.; Treadway, J.L.; Vanvolkenburg, M.A.; Zhao, Z.; Cox, E.D.
(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization
Bioorg. Med. Chem. Lett.
17
5638-5642
2007
Homo sapiens
Kaelin, D.E.; Smenton, A.L.; Eiermann, G.J.; He, H.; Leiting, B.; Lyons, K.A.; Patel, R.A.; Patel, S.B.; Petrov, A.; Scapin, G.; Wu, J.K.; Thornberry, N.A.; Weber, A.E.; Duffy, J.L.
4-Arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV
Bioorg. Med. Chem. Lett.
17
5806-5811
2007
Homo sapiens
Chen, P.; Caldwell, C.G.; Mathvink, R.J.; Leiting, B.; Marsilio, F.; Patel, R.A.; Wu, J.K.; He, H.; Lyons, K.A.; Thornberry, N.A.; Weber, A.E.
Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes
Bioorg. Med. Chem. Lett.
17
5853-5857
2007
Rattus norvegicus
Kowalchick, J.E.; Leiting, B.; Pryor, K.D.; Marsilio, F.; Wu, J.K.; He, H.; Lyons, K.A.; Eiermann, G.J.; Petrov, A.; Scapin, G.; Patel, R.A.; Thornberry, N.A.; Weber, A.E.; Kim, D.
Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors
Bioorg. Med. Chem. Lett.
17
5934-5939
2007
Homo sapiens
Simpkins, L.M.; Bolton, S.; Pi, Z.; Sutton, J.C.; Kwon, C.; Zhao, G.; Magnin, D.R.; Augeri, D.J.; Gungor, T.; Rotella, D.P.; Sun, Z.; Liu, Y.; Slusarchyk, W.S.; Marcinkeviciene, J.; Robertson, J.G.; Wang, A.; Robl, J.A.; Atwal, K.S.; Zahler, R.L.; Parker, R.A.; Kirby, M.S.; Hamann, L.G.
Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
17
6476-6480
2007
Homo sapiens
Corbett, J.W.; Dirico, K.; Song, W.; Boscoe, B.P.; Doran, S.D.; Boyer, D.; Qiu, X.; Ammirati, M.; Vanvolkenburg, M.A.; McPherson, R.K.; Parker, J.C.; Cox, E.D.
Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors
Bioorg. Med. Chem. Lett.
17
6707-6713
2007
Rattus norvegicus, Homo sapiens (P27487), Homo sapiens
Wallace, M.B.; Feng, J.; Zhang, Z.; Skene, R.J.; Shi, L.; Caster, C.L.; Kassel, D.B.; Xu, R.; Gwaltney, S.L.
Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
18
2362-2367
2008
Homo sapiens (P27487)
Edmondson, S.D.; Wei, L.; Xu, J.; Shang, J.; Xu, S.; Pang, J.; Chaudhary, A.; Dean, D.C.; He, H.; Leiting, B.; Lyons, K.A.; Patel, R.A.; Patel, S.B.; Scapin, G.; Wu, J.K.; Beconi, M.G.; Thornberry, N.A.; Weber, A.E.
Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
18
2409-2413
2008
Rattus norvegicus
Taldone, T.; Zito, S.W.; Talele, T.T.
Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin
Bioorg. Med. Chem. Lett.
18
479-484
2008
Sus scrofa
Bergman, A.; Mistry, G.C.; Luo, W.L.; Liu, Q.; Stone, J.; Wang, A.; Zeng, W.; Chen, L.; Dilzer, S.; Lasseter, K.; Herman, G.A.; Wagner, J.A.; Krishna, R.
Dose-proportionality of a final market image sitagliptin formulation, an oral dipeptidyl peptidase-4 inhibitor, in healthy volunteers
Biopharm. Drug Dispos.
28
307-313
2007
Homo sapiens
Bergman, A.; Ebel, D.; Liu, F.; Stone, J.; Wang, A.; Zeng, W.; Chen, L.; Dilzer, S.; Lasseter, K.; Herman, G.; Wagner, J.; Krishna, R.
Absolute bioavailability of sitagliptin, an oral dipeptidyl peptidase-4 inhibitor, in healthy volunteers
Biopharm. Drug Dispos.
28
315-322
2007
Homo sapiens
McIntyre, H.F.; Grant, P.
Dipeptidyl peptidase-IV inhibitors: fixing type 2 diabetes?
Br. J. Hosp. Med. (Lond. )
68
599-602
2007
Homo sapiens
Inamoto, T.; Yamochi, T.; Ohnuma, K.; Iwata, S.; Kina, S.; Inamoto, S.; Tachibana, M.; Katsuoka, Y.; Dang, N.H.; Morimoto, C.
Anti-CD26 monoclonal antibody-mediated G1-S arrest of human renal clear cell carcinoma Caki-2 is associated with retinoblastoma substrate dephosphorylation, cyclin-dependent kinase 2 reduction, p27(kip1) enhancement, and disruption of binding to the extra
Clin. Cancer Res.
12
3470-3477
2006
Mus musculus
Jackson, E.K.; Dubinion, J.H.; Mi, Z.
Effects of dipeptidyl peptidase iv inhibition on arterial blood pressure
Clin. Exp. Pharmacol. Physiol.
35
29-34
2008
Rattus norvegicus
He, Y.L.; Sadler, B.M.; Sabo, R.; Balez, S.; Wang, Y.; Campestrini, J.; Laurent, A.; Ligueros-Saylan, M.; Howard, D.
The absolute oral bioavailability and population-based pharmacokinetic modelling of a novel dipeptidylpeptidase-IV inhibitor, vildagliptin, in healthy volunteers
Clin. Pharmacokinet.
46
787-802
2007
Homo sapiens
Herman, G.A.; Stein, P.P.; Thornberry, N.A.; Wagner, J.A.
Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: focus on sitagliptin
Clin. Pharmacol. Ther.
81
761-767
2007
Homo sapiens
Rosenstock, J.; Brazg, R.; Andryuk, P.J.; Lu, K.; Stein, P.; Stein, P.
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
Clin. Ther.
28
1556-1568
2006
Homo sapiens
OFarrell, A.M.; van Vliet, A.; Abou Farha, K.; Cherrington, J.M.; Campbell, D.A.; Li, X.; Hanway, D.; Li, J.; Guler, H.P.
Pharmacokinetic and pharmacodynamic assessments of the dipeptidyl peptidase-4 inhibitor PHX1149: double-blind, placebo-controlled, single- and multiple-dose studies in healthy subjects
Clin. Ther.
29
1692-1705
2007
Homo sapiens
Ahren, B.
GLP-1-based therapy of type 2 diabetes: GLP-1 mimetics and DPP-IV inhibitors
Curr. Diab. Rep.
7
340-347
2007
Homo sapiens
Herman, G.A.; Bergman, A.; Yi, B.; Kipnes, M.; Kipnes, M.
Tolerability and pharmacokinetics of metformin and the dipeptidyl peptidase-4 inhibitor sitagliptin when co-administered in patients with type 2 diabetes
Curr. Med. Res. Opin.
22
1939-1947
2006
Homo sapiens
He, Y.L.; Sabo, R.; Riviere, G.J.; Sunkara, G.; Leon, S.; Ligueros-Saylan, M.; Rosenberg, M.; Dole, W.P.; Howard, D.
Effect of the novel oral dipeptidyl peptidase IV inhibitor vildagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects
Curr. Med. Res. Opin.
23
1131-1138
2007
Homo sapiens
Pratley, R.E.; Salsali, A.
Inhibition of DPP-4: a new therapeutic approach for the treatment of type 2 diabetes
Curr. Med. Res. Opin.
23
919-931
2007
Homo sapiens
Rosenstock, J.; Zinman, B.
Dipeptidyl peptidase-4 inhibitors and the management of type 2 diabetes mellitus
Curr. Opin. Endocrinol. Diabetes Obes.
14
98-107
2007
Homo sapiens
Mest, H.J.
Dipeptidyl peptidase-IV inhibitors can restore glucose homeostasis in type 2 diabetics via incretin enhancement
Curr. Opin. Investig. Drugs
7
338-343
2006
Homo sapiens
Epstein, B.J.
Drug evaluation: PSN-9301, a short-acting inhibitor of dipeptidyl peptidase IV
Curr. Opin. Investig. Drugs
8
331-337
2007
Homo sapiens
Sebokova, E.; Christ, A.D.; Boehringer, M.; Mizrahi, J.
Dipeptidyl peptidase IV inhibitors: the next generation of new promising therapies for the management of type 2 diabetes
Curr. Top. Med. Chem.
7
547-555
2007
Homo sapiens
Thornberry, N.A.; Weber, A.E.
Discovery of JANUVIATM (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Curr. Top. Med. Chem.
7
557-568
2007
Homo sapiens
Peters, J.U.
11 Years of cyanopyrrolidines as DPP-IV inhibitors
Curr. Top. Med. Chem.
7
579-595
2007
Homo sapiens
Vella, A.; Bock, G.; Giesler, P.D.; Burton, D.B.; Serra, D.B.; Saylan, M.L.; Dunning, B.E.; Foley, J.E.; Rizza, R.A.; Camilleri, M.
Effects of dipeptidyl peptidase-4 inhibition on gastrointestinal function, meal appearance, and glucose metabolism in type 2 diabetes
Diabetes
56
1475-1480
2007
Homo sapiens
Raun, K.; von Voss, P.; Gotfredsen, C.F.; Golozoubova, V.; Rolin, B.; Knudsen, L.B.
Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not
Diabetes
56
8-15
2007
Rattus norvegicus
Aschner, P.; Kipnes, M.S.; Lunceford, J.K.; Sanchez, M.; Mickel, C.; Williams-Herman, D.E.; Williams-Herman, D.E.
Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
Diabetes Care
29
2632-2637
2006
Homo sapiens
Charbonnel, B.; Karasik, A.; Liu, J.; Wu, M.; Meininger, G.; Meininger, G.
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
Diabetes Care
29
2638-2643
2006
Homo sapiens
Drucker, D.J.
Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of action
Diabetes Care
30
1335-1343
2007
Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Rosenstock, J.; Foley, J.E.; Rendell, M.; Landin-Olsson, M.; Holst, J.J.; Deacon, C.F.; Rochotte, E.; Baron, M.A.
Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance
Diabetes Care
31
30-35
2008
Homo sapiens
McKennon, S.A.; Campbell, R.K.
The physiology of incretin hormones and the basis for DPP-4 inhibitors
Diabetes Educ.
33
55-66
2007
Homo sapiens, Rattus norvegicus
Idris, I.; Donnelly, R.
Dipeptidyl peptidase-IV inhibitors: a major new class of oral antidiabetic drug
Diabetes Obes. Metab.
9
153-165
2007
Homo sapiens
Brazg, R.; Xu, L.; Dalla Man, C.; Cobelli, C.; Thomas, K.; Stein, P.P.
Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes
Diabetes Obes. Metab.
9
186-193
2007
Homo sapiens
Nauck, M.A.; Meininger, G.; Sheng, D.; Terranella, L.; Stein, P.P.; Stein, P.P.
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial
Diabetes Obes. Metab.
9
194-205
2007
Homo sapiens
Augstein, P.; Berg, S.; Heinke, P.; Altmann, S.; Salzsieder, E.; Demuth, H.U.; Freyse, E.J.
Efficacy of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide (P32/98) in fatty Zucker rats with incipient and manifest impaired glucose tolerance
Diabetes Obes. Metab.
10
850-861
2008
Rattus norvegicus
Raz, I.; Hanefeld, M.; Xu, L.; Caria, C.; Williams-Herman, D.; Khatami, H.; Khatami, H.
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
Diabetologia
49
2564-2571
2006
Homo sapiens
Beconi, M.G.; Reed, J.R.; Teffera, Y.; Xia, Y.Q.; Kochansky, C.J.; Liu, D.Q.; Xu, S.; Elmore, C.S.; Ciccotto, S.; Hora, D.F.; Stearns, R.A.; Vincent, S.H.
Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs
Drug Metab. Dispos.
35
525-532
2007
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
Ristic, S.; Bates, P.C.
Vildagliptin: a novel DPP-4 inhibitor with pancreatic islet enhancement activity for treatment of patients with type 2 diabetes
Drugs Today
42
519-531
2006
Homo sapiens
Gallwitz, B.
Sitagliptin: Profile of a novel DPP-4 inhibitor for the treatment of type 2 diabetes
Drugs Today
43
13-25
2007
Homo sapiens
Gallwitz, B.
Sitagliptin: profile of a novel DPP-4 inhibitor for the treatment of type 2 diabetes (update)
Drugs Today
43
801-814
2007
Homo sapiens
Ruth, D.M.; Buckley, S.J.; OConnor, B.F.; OFagain, C.
Solvent and thermal stability, and pH kinetics, of proline-specific dipeptidyl peptidase IV-like enzyme from bovine serum
Enzyme Microb. Technol.
41
307-311
2007
Bos taurus
-
He, Y.L.; Sabo, R.; Campestrini, J.; Wang, Y.; Ligueros-Saylan, M.; Lasseter, K.C.; Dilzer, S.C.; Howard, D.; Dole, W.P.
The influence of hepatic impairment on the pharmacokinetics of the dipeptidyl peptidase IV (DPP-4) inhibitor vildagliptin
Eur. J. Clin. Pharmacol.
63
677-686
2007
Homo sapiens
Lu, I.L.; Tsai, K.C.; Chiang, Y.K.; Jiaang, W.T.; Wu, S.H.; Mahindroo, N.; Chien, C.H.; Lee, S.J.; Chen, X.; Chao, Y.S.; Wu, S.Y.
A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors
Eur. J. Med. Chem.
43
1603-1611
2007
Homo sapiens
Jun, M.A.; Park, W.S.; Kang, S.K.; Kim, K.Y.; Kim, K.R.; Rhee, S.D.; Bae, M.A.; Kang, N.S.; Sohn, S.K.; Kim, S.G.; Lee, J.O.; Lee, D.H.; Cheon, H.G.; Kim, S.S.; Ahn, J.H.
Synthesis and biological evaluation of pyrazoline analogues with beta-amino acyl group as dipeptidyl peptidase IV inhibitors
Eur. J. Med. Chem.
43
1889-1902
2008
Homo sapiens (P27487)
Green, B.D.; Irwin, N.; Duffy, N.A.; Gault, V.A.; Oharte, F.P.; Flatt, P.R.
Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1
Eur. J. Pharmacol.
547
192-199
2006
Mus musculus
Yasuda, N.; Nagakura, T.; Inoue, T.; Yamazaki, K.; Katsutani, N.; Takenaka, O.; Clark, R.; Matsuura, F.; Emori, E.; Yoshikawa, S.; Kira, K.; Ikuta, H.; Okada, T.; Saeki, T.; Asano, O.; Tanaka, I.
E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor
Eur. J. Pharmacol.
548
181-187
2006
Canis lupus familiaris, Homo sapiens, Mus musculus
Duffy, N.A.; Green, B.D.; Irwin, N.; Gault, V.A.; McKillop, A.M.; OHarte, F.P.; Flatt, P.R.
Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1
Eur. J. Pharmacol.
568
278-286
2007
Homo sapiens
Faidley, T.D.; Leiting, B.; Pryor, K.D.; Lyons, K.; Hickey, G.J.; Thompson, D.R.
Inhibition of dipeptidyl-peptidase IV does not increase circulating IGF-1 concentrations in growing pigs
Exp. Biol. Med.
231
1373-1378
2006
Sus scrofa
Deacon, C.F.
Dipeptidyl peptidase 4 inhibition with sitagliptin: a new therapy for type 2 diabetes
Expert Opin. Investig. Drugs
16
533-545
2007
Homo sapiens
Green, B.D.; Flatt, P.R.; Bailey, C.J.
Inhibition of dipeptidylpeptidase IV activity as a therapy of type 2 diabetes
Expert. Opin. Emerg. Drugs
11
525-539
2006
Homo sapiens, Mus musculus, Rattus norvegicus
McIntosh, C.H.
Dipeptidyl peptidase IV inhibitors and diabetes therapy
Front. Biosci.
13
1753-1773
2008
Homo sapiens
Deacon, C.F.; Carr, R.D.; Holst, J.J.
DPP-4 inhibitor therapy: new directions in the treatment of type 2 diabetes
Front. Biosci.
13
1780-1794
2008
Homo sapiens
Campbell, T.B.; Broxmeyer, H.E.
CD26 inhibition and hematopoiesis: a novel approach to enhance transplantation
Front. Biosci.
13
1795-1805
2008
Homo sapiens, Mus musculus
Pratley, R.E.; Jauffret-Kamel, S.; Galbreath, E.; Holmes, D.
Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes
Horm. Metab. Res.
38
423-428
2006
Homo sapiens
Byrd, J.B.; Touzin, K.; Sile, S.; Gainer, J.V.; Yu, C.; Nadeau, J.; Adam, A.; Brown, N.J.
Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema
Hypertension
51
141-147
2008
Homo sapiens
Barnett, A.
DPP-4 inhibitors and their potential role in the management of type 2 diabetes
Int. J. Clin. Pract.
60
1454-1470
2006
Homo sapiens
Yates, N.A.; Deyanova, E.G.; Geissler, W.; Wiener, M.C.; Sachs, J.R.; Wong, K.K.; Thornberry, N.A.; Sinha Roy, R.; Settlage, R.E.; Hendrickson, R.C.
Identification of peptidase substrates in human plasma by FTMS based differential mass spectrometry
Int. J. Mass Spectrom.
259
174-183
2007
Homo sapiens
-
Byrd, J.B.; Shreevatsa, A.; Putlur, P.; Foretia, D.; McAlexander, L.; Sinha, T.; Does, M.D.; Brown, N.J.
Dipeptidyl peptidase IV deficiency increases susceptibility to angiotensin-converting enzyme inhibitor-induced peritracheal edema
J. Allergy Clin. Immunol.
120
403-408
2007
Rattus norvegicus
Hinnen, D.; Nielsen, L.L.; Waninger, A.; Kushner, P.
Incretin mimetics and DPP-IV inhibitors: new paradigms for the treatment of type 2 diabetes
J. Am. Board. Fam. Med.
19
612-620
2006
Homo sapiens
Boyle, P.J.; Freeman, J.S.
Application of incretin mimetics and dipeptidyl peptidase IV inhibitors in managing type 2 diabetes mellitus
J. Am. Osteopath. Assoc.
107 Suppl
S10-S16
2007
Homo sapiens
Herman, G.A.; Bergman, A.; Stevens, C.; Kotey, P.; Yi, B.; Zhao, P.; Dietrich, B.; Golor, G.; Schrodter, A.; Keymeulen, B.; Lasseter, K.C.; Kipnes, M.S.; Snyder, K.; Hilliard, D.; Tanen, M.; Cilissen, C.; De Smet, M.; de Lepeleire, I.; Van Dyck, K.; Wang, A.Q.; Zeng, W.; Davies, M.J.; Tanaka, W.; Holst, J.J.
Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes
J. Clin. Endocrinol. Metab.
91
4612-4619
2006
Homo sapiens
Balas, B.; Baig, M.R.; Watson, C.; Dunning, B.E.; Ligueros-Saylan, M.; Wang, Y.; He, Y.L.; Darland, C.; Holst, J.J.; Deacon, C.F.; Cusi, K.; Mari, A.; Foley, J.E.; DeFronzo, R.A.
The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients
J. Clin. Endocrinol. Metab.
92
1249-1255
2007
Homo sapiens
Sunkara, G.; Sabo, R.; Wang, Y.; He, Y.L.; Campestrini, J.; Rosenberg, M.; Howard, D.; Dole, W.P.
Dose proportionality and the effect of food on vildagliptin, a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers
J. Clin. Pharmacol.
47
1152-1158
2007
Homo sapiens
Mistry, G.C.; Bergman, A.J.; Luo, W.L.; Cilissen, C.; Haazen, W.; Davies, M.J.; Gottesdiener, K.M.; Wagner, J.A.; Herman, G.A.
Multiple-dose administration of sitagliptin, a dipeptidyl peptidase-4 inhibitor, does not alter the single-dose pharmacokinetics of rosiglitazone in healthy subjects
J. Clin. Pharmacol.
47
159-164
2007
Homo sapiens
Krishna, R.; Bergman, A.; Larson, P.; Cote, J.; Lasseter, K.; Dilzer, S.; Wang, A.; Zeng, W.; Chen, L.; Wagner, J.; Herman, G.
Effect of a single cyclosporine dose on the single-dose pharmacokinetics of sitagliptin (MK-0431), a dipeptidyl peptidase-4 inhibitor, in healthy male subjects
J. Clin. Pharmacol.
47
165-174
2007
Homo sapiens
He, Y.L.; Sabo, R.; Sunkara, G.; Bizot, M.N.; Riviere, G.J.; Leon, S.; Ligueros-Saylan, M.; Dole, W.P.; Howard, D.
Evaluation of pharmacokinetic interactions between vildagliptin and digoxin in healthy volunteers
J. Clin. Pharmacol.
47
998-1004
2007
Homo sapiens
He, Y.L.; Ligueros-Saylan, M.; Sunkara, G.; Sabo, R.; Zhao, C.; Wang, Y.; Campestrini, J.; Pommier, F.; Dole, K.; Marion, A.; Dole, W.P.; Howard, D.
Vildagliptin, a novel dipeptidyl peptidase IV inhibitor, has no pharmacokinetic interactions with the antihypertensive agents amlodipine, valsartan, and ramipril in healthy subjects
J. Clin. Pharmacol.
48
85-95
2008
Homo sapiens
Crepaldi, G.; Carruba, M.; Comaschi, M.; Del Prato, S.; Frajese, G.; Paolisso, G.
Dipeptidyl peptidase 4 (DPP-4) inhibitors and their role in type 2 diabetes anagement
J. Endocrinol. Invest.
30
610-614
2007
Homo sapiens
Zhai, W.; Cardell, M.; De Meester, I.; Augustyns, K.; Hillinger, S.; Inci, I.; Arni, S.; Jungraithmayr, W.; Scharpe, S.; Weder, W.; Korom, S.
Intragraft DPP IV inhibition attenuates post-transplant pulmonary ischemia/reperfusion injury after extended ischemia
J. Heart Lung Transplant.
26
174-180
2007
Rattus norvegicus
Preller, V.; Gerber, A.; Wrenger, S.; Togni, M.; Marguet, D.; Tadje, J.; Lendeckel, U.; Roecken, C.; Faust, J.; Neubert, K.; Schraven, B.; Martin, R.; Ansorge, S.; Brocke, S.; Reinhold, D.
TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26
J. Immunol.
178
4632-4640
2007
Mus musculus
Thielitz, A.; Reinhold, D.; Vetter, R.; Bank, U.; Helmuth, M.; Hartig, R.; Wrenger, S.; Wiswedel, I.; Lendeckel, U.; Kaehne, T.; Neubert, K.; Faust, J.; Zouboulis, C.C.; Ansorge, S.; Gollnick, H.
Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation
J. Invest. Dermatol.
127
1042-1051
2007
Homo sapiens
Tsu, H.; Chen, X.; Chen, C.T.; Lee, S.J.; Chang, C.N.; Kao, K.H.; Coumar, M.S.; Yeh, Y.T.; Chien, C.H.; Wang, H.S.; Lin, K.T.; Chang, Y.Y.; Wu, S.H.; Chen, Y.S.; Lu, I.L.; Wu, S.Y.; Tsai, T.Y.; Chen, W.C.; Hsieh, H.P.; Chao, Y.S.; Jiaang, W.T.
2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV
J. Med. Chem.
49
373-380
2006
Homo sapiens
Madar, D.J.; Kopecka, H.; Pireh, D.; Yong, H.; Pei, Z.; Li, X.; Wiedeman, P.E.; Djuric, S.W.; Von Geldern, T.W.; Fickes, M.G.; Bhagavatula, L.; McDermott, T.; Wittenberger, S.; Richards, S.J.; Longenecker, K.L.; Stewart, K.D.; Lubben, T.H.; Ballaron, S.J.; Stashko, M.A.; Long, M.A.; Wells, H.; Zinker, B.A.
Discovery of (2-(4-((2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes
J. Med. Chem.
49
6416-6420
2006
Canis lupus familiaris, Rattus norvegicus, Homo sapiens (P27487)
Clairmont, K.B.; Buckholz, T.M.; Pellegrino, C.M.; Buxton, J.M.; Barucci, N.; Bell, A.; Ha, S.; Li, F.; Claus, T.H.; Salhanick, A.I.; Lumb, K.J.
Engineering of a VPAC2 receptor peptide agonist to impart dipeptidyl peptidase IV stability and enhance in vivo glucose disposal
J. Med. Chem.
49
7545-7548
2006
Homo sapiens
Pei, Z.; Li, X.; von Geldern, T.W.; Longenecker, K.; Pireh, D.; Stewart, K.D.; Backes, B.J.; Lai, C.; Lubben, T.H.; Ballaron, S.J.; Beno, D.W.; Kempf-Grote, A.J.; Sham, H.L.; Trevillyan, J.M.
Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors
J. Med. Chem.
50
1983-1987
2007
Homo sapiens (P27487)
Feng, J.; Zhang, Z.; Wallace, M.B.; Stafford, J.A.; Kaldor, S.W.; Kassel, D.B.; Navre, M.; Shi, L.; Skene, R.J.; Asakawa, T.; Takeuchi, K.; Xu, R.; Webb, D.R.; Gwaltney, S.L.
Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV
J. Med. Chem.
50
2297-2300
2007
Rattus norvegicus
Lai, J.H.; Wu, W.; Zhou, Y.; Maw, H.H.; Liu, Y.; Milo, L.J.; Poplawski, S.E.; Henry, G.D.; Sudmeier, J.L.; Sanford, D.G.; Bachovchin, W.W.
Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: amino-lactam boroalanines
J. Med. Chem.
50
2391-2398
2007
Homo sapiens
Eckhardt, M.; Langkopf, E.; Mark, M.; Tadayyon, M.; Thomas, L.; Nar, H.; Pfrengle, W.; Guth, B.; Lotz, R.; Sieger, P.; Fuchs, H.; Himmelsbach, F.
8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes
J. Med. Chem.
50
6450-6453
2007
Canis lupus familiaris, Macaca mulatta, Rattus norvegicus, Homo sapiens (P27487)
Kim, D.; Kowalchick, J.E.; Brockunier, L.L.; Parmee, E.R.; Eiermann, G.J.; Fisher, M.H.; He, H.; Leiting, B.; Lyons, K.; Scapin, G.; Patel, S.B.; Petrov, A.; Pryor, K.D.; Roy, R.S.; Wu, J.K.; Zhang, X.; Wyvratt, M.J.; Zhang, B.B.; Zhu, L.; Thornberry, N.A.; Weber, A.E.
Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines
J. Med. Chem.
51
589-602
2008
Rattus norvegicus
Pissurlenkar, R.R.; Shaikh, M.S.; Coutinho, E.C.
3D-QSAR studies of dipeptidyl peptidase IV inhibitors using a docking based alignment
J. Mol. Model.
13
1047-1071
2007
Mus musculus, Homo sapiens (P27487)
Zeng, J.; Liu, G.; Tang, Y.; Jiang, H.
3D-QSAR studies on fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors by CoMFA and CoMSIA
J. Mol. Model.
13
993-1000
2007
Homo sapiens (P27487)
Yamazaki, K.; Yasuda, N.; Inoue, T.; Nagakura, T.; Kira, K.; Shinoda, M.; Saeki, T.; Tanaka, I.
7-But-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one is a novel competitive and selective inhibitor of dipeptidyl peptidase IV with an antihyperglycemic activity
J. Pharmacol. Exp. Ther.
319
1253-1257
2006
Homo sapiens
Yamazaki, K.; Yasuda, N.; Inoue, T.; Yamamoto, E.; Sugaya, Y.; Nagakura, T.; Shinoda, M.; Clark, R.; Saeki, T.; Tanaka, I.
Effects of the combination of a dipeptidyl peptidase IV inhibitor and an insulin secretagogue on glucose and insulin levels in mice and rats
J. Pharmacol. Exp. Ther.
320
738-746
2007
Mus musculus, Rattus norvegicus
Chu, X.Y.; Bleasby, K.; Yabut, J.; Cai, X.; Chan, G.H.; Hafey, M.J.; Xu, S.; Bergman, A.J.; Braun, M.P.; Dean, D.C.; Evers, R.
Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein
J. Pharmacol. Exp. Ther.
321
673-683
2007
Homo sapiens
Jackson, E.K.; Zhang, M.; Liu, W.; Mi, Z.
Inhibition of renal dipeptidyl peptidase IV enhances peptide YY1-36-induced potentiation of angiotensin II-mediated renal vasoconstriction in spontaneously hypertensive rats
J. Pharmacol. Exp. Ther.
323
431-437
2007
Rattus norvegicus
Roy, S.; Khanna, V.; Mittra, S.; Dhar, A.; Singh, S.; Mahajan, D.C.; Priyadarsiny, P.; Davis, J.A.; Sattigeri, J.; Saini, K.S.; Bansal, V.S.
Combination of dipeptidylpeptidase IV inhibitor and low dose thiazolidinedione: preclinical efficacy and safety in db/db mice
Life Sci.
81
72-79
2007
Mus musculus
Bourgault, S.; Vaudry, D.; Botia, B.; Couvineau, A.; Laburthe, M.; Vaudry, H.; Fournier, A.
Novel stable PACAP analogs with potent activity towards the PAC1 receptor
Peptides
29
919-932
2008
Sus scrofa
Triplitt, C.; Wright, A.; Chiquette, E.
Incretin mimetics and dipeptidyl peptidase-IV inhibitors: potential new therapies for type 2 diabetes mellitus
Pharmacotherapy
26
360-374
2006
Homo sapiens
Langley, A.K.; Suffoletta, T.J.; Jennings, H.R.
Dipeptidyl peptidase IV inhibitors and the incretin system in type 2 diabetes mellitus
Pharmacotherapy
27
1163-1180
2007
Homo sapiens
Davoodi, J.; Kelly, J.; Gendron, N.H.; MacKenzie, A.E.
The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26
Proteomics
7
2300-2310
2007
Homo sapiens
Masur, K.; Schwartz, F.; Entschladen, F.; Niggemann, B.; Zaenker, K.S.
DPPIV inhibitors extend GLP-2 mediated tumour promoting effects on intestinal cancer cells
Regul. Pept.
137
147-155
2006
Homo sapiens
Ahren, B.; Winzell, M.S.; Wierup, N.; Sundler, F.; Burkey, B.; Hughes, T.E.
DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide
Regul. Pept.
143
97-103
2007
Mus musculus
Campbell, T.B.; Hangoc, G.; Liu, Y.; Pollok, K.; Broxmeyer, H.E.
Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice
Stem Cells Dev.
16
347-354
2007
Homo sapiens
Christopherson, K.W.; Paganessi, L.A.; Napier, S.; Porecha, N.K.
CD26 inhibition on CD34+ or lineage- human umbilical cord blood donor hematopoietic stem cells/hematopoietic progenitor cells improves long-term engraftment into NOD/SCID/Beta2null immunodeficient mice
Stem Cells Dev.
16
355-360
2007
Homo sapiens
Zhai, W.; Cardell, M.; De Meester, I.; Augustyns, K.; Hillinger, S.; Inci, I.; Arni, S.; Jungraithmayr, W.; Scharpe, S.; Weder, W.; Korom, S.
Ischemia/reperfusion injury: The role of CD26/dipeptidyl-peptidase-IV-inhibition in lung transplantation
Transplant. Proc.
38
3369-3371
2006
Rattus norvegicus
Moore, K.B.; Saudek, C.D.
Therapeutic potential of dipeptidyl peptidase-IV inhibitors in patients with diabetes mellitus
Am. J. Ther.
15
484-491
2008
Homo sapiens
Tang, H.K.; Tang, H.Y.; Hsu, S.C.; Chu, Y.R.; Chien, C.H.; Shu, C.H.; Chen, X.
Biochemical properties and expression profile of human prolyl dipeptidase DPP9
Arch. Biochem. Biophys.
485
120-127
2009
Homo sapiens
Matsuyama-Yokono, A.; Tahara, A.; Nakano, R.; Someya, Y.; Nagase, I.; Hayakawa, M.; Shibasaki, M.
ASP8497 is a novel selective and competitive dipeptidyl peptidase-IV inhibitor with antihyperglycemic activity
Biochem. Pharmacol.
76
98-107
2008
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Jost, M.M.; Lamerz, J.; Tammen, H.; Menzel, C.; De Meester, I.; Lambeir, A.M.; Augustyns, K.; Scharpe, S.; Zucht, H.D.; Rose, H.; Juergens, M.; Schulz-Knappe, P.; Budde, P.
In vivo profiling of DPP4 inhibitors reveals alterations in collagen metabolism and accumulation of an amyloid peptide in rat plasma
Biochem. Pharmacol.
77
228-237
2009
Homo sapiens, Rattus norvegicus
Eckhardt, M.; Hauel, N.; Himmelsbach, F.; Langkopf, E.; Nar, H.; Mark, M.; Tadayyon, M.; Thomas, L.; Guth, B.; Lotz, R.
3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: a class of potent DPP-4 inhibitors
Bioorg. Med. Chem. Lett.
18
3158-3162
2008
Homo sapiens, Rattus norvegicus
Liang, G.B.; Qian, X.; Biftu, T.; Singh, S.; Gao, Y.D.; Scapin, G.; Patel, S.; Leiting, B.; Patel, R.; Wu, J.; Zhang, X.; Thornberry, N.A.; Weber, A.E.
Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design
Bioorg. Med. Chem. Lett.
18
3706-3710
2008
Homo sapiens
Ahn, J.H.; Park, W.S.; Jun, M.A.; Shin, M.S.; Kang, S.K.; Kim, K.Y.; Rhee, S.D.; Bae, M.A.; Kim, K.R.; Kim, S.G.; Kim, S.Y.; Sohn, S.K.; Kang, N.S.; Lee, J.O.; Lee, D.H.; Cheon, H.G.; Kim, S.S.
Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
18
6525-6529
2008
Homo sapiens (P27487), Homo sapiens
Tsai, T.Y.; Hsu, T.; Chen, C.T.; Cheng, J.H.; Chiou, M.C.; Huang, C.H.; Tseng, Y.J.; Yeh, T.K.; Huang, C.Y.; Yeh, K.C.; Huang, Y.W.; Wu, S.H.; Wang, M.H.; Chen, X.; Chao, Y.S.; Jiaang, W.T.
Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
19
1908-1912
2009
Rattus norvegicus
Ammirati, M.J.; Andrews, K.M.; Boyer, D.D.; Brodeur, A.M.; Danley, D.E.; Doran, S.D.; Hulin, B.; Liu, S.; McPherson, R.K.; Orena, S.J.; Parker, J.C.; Polivkova, J.; Qiu, X.; Soglia, C.B.; Treadway, J.L.; VanVolkenburg, M.A.; Wilder, D.C.; Piotrowski, D.W.
(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl)-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor
Bioorg. Med. Chem. Lett.
19
1991-1995
2009
Homo sapiens (P27487)
Tsai, T.Y.; Hsu, T.; Chen, C.T.; Cheng, J.H.; Yeh, T.K.; Chen, X.; Huang, C.Y.; Chang, C.N.; Yeh, K.C.; Hsieh, S.H.; Chien, C.H.; Chang, Y.W.; Huang, C.H.; Huang, Y.W.; Huang, C.L.; Wu, S.H.; Wang, M.H.; Lu, C.T.; Chao, Y.S.; Jiaang, W.T.
Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem.
17
2388-2399
2009
Rattus norvegicus
Hu, C.X.; Huang, H.; Zhang, L.; Huang, Y.; Shen, Z.F.; Cheng, K.D.; Du, G.H.; Zhu, P.
A new screening method based on yeast-expressed human dipeptidyl peptidase IV and discovery of novel inhibitors
Biotechnol. Lett.
31
979-984
2009
Homo sapiens (P27487), Homo sapiens
Fukushima, H.; Hiratate, A.; Takahashi, M.; Saito-Hori, M.; Munetomo, E.; Kitano, K.; Saito, H.; Takaoka, Y.; Yamamoto, K.
Synthesis and structure-activity relationships of potent 1-(2-substituted-aminoacetyl)-4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors
Chem. Pharm. Bull.
56
1110-1117
2008
Homo sapiens
Ansorge, S.; Bank, U.; Heimburg, A.; Helmuth, M.; Koch, G.; Tadje, J.; Lendeckel, U.; Wolke, C.; Neubert, K.; Faust, J.; Fuchs, P.; Reinhold, D.; Thielitz, A.; Taeger, M.
Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions
Clin. Chem. Lab. Med.
47
253-261
2009
Mus musculus
Christopher, R.; Covington, P.; Davenport, M.; Fleck, P.; Mekki, Q.A.; Wann, E.R.; Karim, A.
Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects
Clin. Ther.
30
513-527
2008
Homo sapiens
Gupta, R.; Walunj, S.S.; Tokala, R.K.; Parsa, K.V.; Singh, S.K.; Pal, M.
Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of type 2 diabetes
Curr. Drug Targets
10
71-87
2009
Homo sapiens
Pei, Z.
From the bench to the bedside: dipeptidyl peptidase IV inhibitors, a new class of oral antihyperglycemic agents
Curr. Opin. Drug Discov. Devel.
11
512-532
2008
Homo sapiens
Deacon, C.F.
Alogliptin, a potent and selective dipeptidyl peptidase-IV inhibitor for the treatment of type 2 diabetes
Curr. Opin. Investig. Drugs
9
402-413
2008
Homo sapiens
Gwaltney, S.L.
Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase IV
Curr. Top. Med. Chem.
8
1545-1552
2008
Homo sapiens
Garcia-Soria, G.; Gonzalez-Galvez, G.; Argoud, G.M.; Gerstman, M.; Littlejohn, T.W.; Schwartz, S.L.; OFarrell, A.M.; Li, X.; Cherrington, J.M.; Bennett, C.; Guler, H.P.
The dipeptidyl peptidase-4 inhibitor PHX1149 improves blood glucose control in patients with type 2 diabetes mellitus
Diabetes Obes. Metab.
10
293-300
2008
Homo sapiens
Dai, H.; Gustavson, S.M.; Preston, G.M.; Eskra, J.D.; Calle, R.; Hirshberg, B.
Non-linear increase in GLP-1 levels in response to DPP-IV inhibition in healthy adult subjects
Diabetes Obes. Metab.
10
506-513
2008
Homo sapiens
Kim, S.J.; Nian, C.; Doudet, D.J.; McIntosh, C.H.
Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice
Diabetes
57
1331-1339
2008
Mus musculus
Edgerton, D.S.; Johnson, K.M.; Neal, D.W.; Scott, M.; Hobbs, C.H.; Zhang, X.; Duttaroy, A.; Cherrington, A.D.
Inhibition of dipeptidyl peptidase-4 by vildagliptin during glucagon-like peptide 1 infusion increases liver glucose uptake in the conscious dog
Diabetes
58
243-249
2009
Canis lupus familiaris
Kim, S.J.; Nian, C.; Doudet, D.J.; McIntosh, C.H.
Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation
Diabetes
58
641-651
2009
Mus musculus, Mus musculus NOD/LtJ
Moritoh, Y.; Takeuchi, K.; Asakawa, T.; Kataoka, O.; Odaka, H.
Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice
Eur. J. Pharmacol.
588
325-332
2008
Mus musculus
Lee, B.; Shi, L.; Kassel, D.B.; Asakawa, T.; Takeuchi, K.; Christopher, R.J.
Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys
Eur. J. Pharmacol.
589
306-314
2008
Canis lupus familiaris, Homo sapiens, Macaca fascicularis, Rattus norvegicus
Moritoh, Y.; Takeuchi, K.; Asakawa, T.; Kataoka, O.; Odaka, H.
The dipeptidyl peptidase-4 inhibitor alogliptin in combination with pioglitazone improves glycemic control, lipid profiles, and increases pancreatic insulin content in ob/ob mice
Eur. J. Pharmacol.
602
448-454
2009
Mus musculus
Tahara, A.; Matsuyama-Yokono, A.; Nakano, R.; Someya, Y.; Hayakawa, M.; Shibasaki, M.
Effects of the combination of dipeptidyl peptidase-IV inhibitor ASP8497 and antidiabetic drugs in streptozotocin-nicotinamide-induced mildly diabetic mice
Eur. J. Pharmacol.
605
170-176
2009
Mus musculus
Ahren, B.
Emerging dipeptidyl peptidase-4 inhibitors for the treatment of diabetes
Expert. Opin. Emerg. Drugs
13
593-607
2008
Homo sapiens
Dubois, V.; Lambeir, A.M.; Van der Veken, P.; Augustyns, K.; Creemers, J.; Chen, X.; Scharpe, S.; De Meester, I.
Purification and characterization of dipeptidyl peptidase IV-like enzymes from bovine testes
Front. Biosci.
13
3558-3568
2008
Bos taurus
Gallwitz, B.
Saxagliptin, a dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
IDrugs
11
906-917
2008
Homo sapiens
Serra, D.; He, Y.L.; Bullock, J.; Riviere, G.J.; Balez, S.; Schwartz, S.; Wang, Y.; Ligueros-Saylan, M.; Jarugula, V.; Dole, W.P.
Evaluation of pharmacokinetic and pharmacodynamic interaction between the dipeptidyl peptidase IV inhibitor vildagliptin, glyburide and pioglitazone in patients with Type 2 diabetes
Int. J. Clin. Pharmacol. Ther.
46
349-364
2008
Homo sapiens
Kadar, E.P.; Wujcik, C.E.
Remediation of undesirable secondary interactions encountered in hydrophilic interaction chromatography during development of a quantitative LC-MS/MS assay for a dipeptidyl peptidase IV (DPP-IV) inhibitor in monkey serum
J. Chromatogr. B
877
471-476
2009
Macaca fascicularis
Boschmann, M.; Engeli, S.; Dobberstein, K.; Budziarek, P.; Strauss, A.; Boehnke, J.; Sweep, F.C.; Luft, F.C.; He, Y.; Foley, J.E.; Jordan, J.
Dipeptidyl-peptidase-IV inhibition augments postprandial lipid mobilization and oxidation in type 2 diabetic patients
J. Clin. Endocrinol. Metab.
94
846-852
2009
Homo sapiens
Forssmann, U.; Stoetzer, C.; Stephan, M.; Kruschinski, C.; Skripuletz, T.; Schade, J.; Schmiedl, A.; Pabst, R.; Wagner, L.; Hoffmann, T.; Kehlen, A.; Escher, S.E.; Forssmann, W.G.; Elsner, J.; von Hoersten, S.
Inhibition of CD26/dipeptidyl peptidase IV enhances CCL11/eotaxin-mediated recruitment of eosinophils in vivo
J. Immunol.
181
1120-1127
2008
Homo sapiens, Rattus norvegicus
Connolly, B.A.; Sanford, D.G.; Chiluwal, A.K.; Healey, S.E.; Peters, D.E.; Dimare, M.T.; Wu, W.; Liu, Y.; Maw, H.; Zhou, Y.; Li, Y.; Jin, Z.; Sudmeier, J.L.; Lai, J.H.; Bachovchin, W.W.
Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety
J. Med. Chem.
51
6005-6013
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Fuchs, H.; Tillement, J.P.; Urien, S.; Greischel, A.; Roth, W.
Concentration-dependent plasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356 due to saturable binding to its target in plasma of mice, rats and humans
J. Pharm. Pharmacol.
61
55-62
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Thomas, L.; Eckhardt, M.; Langkopf, E.; Tadayyon, M.; Himmelsbach, F.; Mark, M.
(R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with oth
J. Pharmacol. Exp. Ther.
325
175-182
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Cheng, Q.; Law, P.K.; de Gasparo, M.; Leung, P.S.
Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N-[[2-(1H-tetrazol-5-yl)-[1,1-biphenyl]-4-yl]methyl]-L-valine ] enhances pancreatic islet morphology and function in a mouse model of type 2 diabetes
J. Pharmacol. Exp. Ther.
327
683-691
2008
Mus musculus
Kuehlmann, U.C.; Chwieralski, C.E.; van den Brule, S.; Roecken, C.; Reinhold, D.; Welte, T.; Buehling, F.
Modulation of cytokine production and silica-induced lung fibrosis by inhibitors of aminopeptidase N and of dipeptidyl peptidase-IV-related proteases
Life Sci.
84
1-11
2009
Homo sapiens, Mus musculus
Liu, X.; Harada, N.; Yamane, S.; Kitajima, L.; Uchida, S.; Hamasaki, A.; Mukai, E.; Toyoda, K.; Yamada, C.; Yamada, Y.; Seino, Y.; Inagaki, N.
Effects of long-term dipeptidyl peptidase-IV inhibition on body composition and glucose tolerance in high fat diet-fed mice
Life Sci.
84
876-881
2009
Mus musculus
Yilmaz, Y.; Atug, O.; Yonal, O.; Duman, D.; Ozdogan, O.; Imeryuz, N.; Kalayci, C.
Dipeptidyl peptidase IV inhibitors: therapeutic potential in nonalcoholic fatty liver disease
Med. Sci. Monit.
15
HY1-HY5
2009
Homo sapiens
Matsuyama-Yokono, A.; Tahara, A.; Nakano, R.; Someya, Y.; Shiraki, K.; Hayakawa, M.; Shibasaki, M.
Antidiabetic effects of dipeptidyl peptidase-IV inhibitors and sulfonylureas in streptozotocin-nicotinamide-induced mildly diabetic mice
Metab. Clin. Exp.
58
379-386
2009
Mus musculus
Michel, M.C.; Fliers, E.; Van Noorden, C.J.
Dipeptidyl peptidase IV inhibitors in diabetes: more than inhibition of glucagon-like peptide-1 metabolism?
Naunyn Schmiedebergs Arch. Pharmacol.
377
205-207
2008
Rattus norvegicus
Someya, Y.; Tahara, A.; Nakano, R.; Matsuyama-Yokono, A.; Nagase, I.; Fukunaga, Y.; Takasu, T.; Hayakawa, M.; Shibasaki, M.
Pharmacological profile of ASP8497, a novel, selective, and competitive dipeptidyl peptidase-IV inhibitor, in vitro and in vivo
Naunyn Schmiedebergs Arch. Pharmacol.
377
209-217
2008
Canis lupus familiaris, Homo sapiens, Mus musculus
Matsuyama-Yokono, A.; Tahara, A.; Nakano, R.; Someya, Y.; Hayakawa, M.; Shibasaki, M.
Chronic inhibition of dipeptidyl peptidase-IV with ASP8497 improved the HbA(1c) level, glucose intolerance, and lipid parameter level in streptozotocin-nicotinamide-induced diabetic mice
Naunyn Schmiedebergs Arch. Pharmacol.
379
191-199
2009
Mus musculus
Tahara, A.; Matsuyama-Yokono, A.; Nakano, R.; Someya, Y.; Hayakawa, M.; Shibasaki, M.
Evaluation of the antidiabetic effects of dipeptidyl peptidase-IV inhibitor ASP8497 in streptozotocin-nicotinamide-induced mildly diabetic mice
Pharmacology
83
177-187
2009
Mus musculus
Ahren, B.
Novel combination treatment of type 2 diabetes DPP-4 inhibition + metformin
Vasc. Health Risk Manag.
4
383-394
2008
Homo sapiens
Furrer, D.; Kaufmann, K.; Tschuor, F.; Reusch, C.E.; Lutz, T.A.
The dipeptidyl peptidase IV inhibitor NVP-DPP728 reduces plasma glucagon concentration in cats
Vet. J.
183
355-357
2009
Felis catus
Pentzien, A.K.; Meisel, H.
Transepithelial transport and stability in blood serum of angiotensin-I-converting enzyme inhibitory dipeptides
Z. Naturforsch. C
63
451-459
2008
Homo sapiens
Kirino, Y.; Kamimoto, T.; Sato, Y.; Kawazoe, K.; Minakuchi, K.; Nakahori, Y.
Increased plasma dipeptidyl peptidase IV (DPP IV) activity and decreased DPP IV activity of visceral but not subcutaneous adipose tissue in impaired glucose tolerance rats induced by high-fat or high-sucrose diet
Biol. Pharm. Bull.
32
463-467
2009
Rattus norvegicus
Nordhoff, S.; Cerezo-Galvez, S.; Deppe, H.; Hill, O.; Lopez-Canet, M.; Rummey, C.; Thiemann, M.; Matassa, V.G.; Edwards, P.J.; Feurer, A.
Discovery of beta-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV
Bioorg. Med. Chem. Lett.
19
4201-4203
2009
Rattus norvegicus
Nordhoff, S.; Lopez-Canet, M.; Hoffmann-Enger, B.; Bulat, S.; Cerezo-Galvez, S.; Hill, O.; Rosenbaum, C.; Rummey, C.; Thiemann, M.; Matassa, V.G.; Edwards, P.J.; Feurer, A.
From lead to preclinical candidate: optimization of beta-homophenylalanine based inhibitors of dipeptidyl peptidase IV
Bioorg. Med. Chem. Lett.
19
4818-4823
2009
Homo sapiens
Gupta, R.C.; Chhipa, L.; Mandhare, A.B.; Zambad, S.P.; Chauthaiwale, V.; Nadkarni, S.S.; Dutt, C.
Novel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor
Bioorg. Med. Chem. Lett.
19
5021-5025
2009
Rattus norvegicus
Boehringer, M.; Fischer, H.; Hennig, M.; Hunziker, D.; Huwyler, J.; Kuhn, B.; Loeffler, B.M.; Luebbers, T.; Mattei, P.; Narquizian, R.; Sebokova, E.; Sprecher, U.; Wessel, H.P.
Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
20
1106-1108
2010
Homo sapiens
Yeh, T.K.; Tsai, T.Y.; Hsu, T.; Cheng, J.H.; Chen, X.; Song, J.S.; Shy, H.S.; Chiou, M.C.; Chien, C.H.; Tseng, Y.J.; Huang, C.Y.; Yeh, K.C.; Huang, Y.L.; Huang, C.H.; Huang, Y.W.; Wang, M.H.; Tang, H.K.; Chao, Y.S.; Chen, C.T.; Jiaang, W.T.
(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV
Bioorg. Med. Chem. Lett.
20
3596-3600
2010
Homo sapiens, Rattus norvegicus
Vora, K.; Porter, G.; Peng, R.; Cui, Y.; Pryor, K.; Eiermann, G.; Zaller, D.
Genetic ablation or pharmacological blockade of dipeptidyl peptidase IV does not impact T cell-dependent immune responses
BMC Immunol.
10
19
2009
Mus musculus
Lim, K.S.; Cho, J.Y.; Kim, B.H.; Kim, J.R.; Kim, H.S.; Kim, D.K.; Kim, S.H.; Yim, H.J.; Lee, S.H.; Shin, S.G.; Jang, I.J.; Yu, K.S.
Pharmacokinetics and pharmacodynamics of LC15-0444, a novel dipeptidyl peptidase IV inhibitor, after multiple dosing in healthy volunteers
Br. J. Clin. Pharmacol.
68
883-890
2009
Homo sapiens
Krupina, N.A.; Kushnareva, E.Y.; Khlebnikova, N.N.; Zolotov, N.N.; Kryzhanovskii, G.N.
Behavioral changes in rats induced by a dipeptidyl peptidase IV inhibitor methionyl-2(S)-cyanopyrrolidine: experimental model of anxiety-depression disorder
Bull. Exp. Biol. Med.
147
285-290
2009
Rattus norvegicus
Kajiyama, H.; Shibata, K.; Ino, K.; Mizutani, S.; Nawa, A.; Kikkawa, F.
The expression of dipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cells
Cancer Sci.
101
347-354
2010
Homo sapiens
Vanderheyden, M.; Bartunek, J.; Goethals, M.; Verstreken, S.; Lambeir, A.M.; De Meester, I.; Scharpe, S.
Dipeptidyl-peptidase IV and B-type natriuretic peptide. From bench to bedside
Clin. Chem. Lab. Med.
47
248-252
2009
Homo sapiens
Reinhold, D.; Goihl, A.; Wrenger, S.; Reinhold, A.; Kuehlmann, U.C.; Faust, J.; Neubert, K.; Thielitz, A.; Brocke, S.; Taeger, M.; Ansorge, S.; Bank, U.
Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice
Clin. Chem. Lab. Med.
47
268-274
2009
Mus musculus
Merchant, M.; Monroe, C.; Falconi, R.
Dipeptidyl peptidase IV activity in the blood of the American alligator (Alligator mississippiensis)
Comp. Biochem. Physiol. B
154
341-345
2009
Alligator mississippiensis
Ge, J.; Feng, Y.; Ji, H.; Zhang, H.; Zheng, F.; Wang, C.; Yin, Z.; Pan, X.; Tang, J.
Inactivation of dipeptidyl peptidase IV attenuates the virulence of Streptococcus suis serotype 2 that causes streptococcal toxic shock syndrome
Curr. Microbiol.
59
248-255
2009
Streptococcus suis
Luft, V.C.; Schmidt, M.I.; Pankow, J.S.; Hoogeveen, R.C.; Couper, D.; Heiss, G.; Duncan, B.B.; Duncan, B.B.
Dipeptidyl peptidase IV and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) study
Diabetes Care
33
1109-1111
2010
Rattus norvegicus
Kuepeli, E.; Karnak, D.; Elguen, S.; Argueder, E.; Kayacan, O.
Concurrent measurement of adenosine deaminase and dipeptidyl peptidase IV activity in the diagnosis of tuberculous pleural effusion
Diagn. Microbiol. Infect. Dis.
65
365-371
2009
Homo sapiens
Wang, L.; Zhang, B.; Ji, J.; Li, B.; Yan, J.; Zhang, W.; Wu, Y.; Wang, X.
Synthesis and evaluation of structurally constrained imidazolidin derivatives as potent dipeptidyl peptidase IV inhibitors
Eur. J. Med. Chem.
44
3318-3322
2009
Homo sapiens
Kiraly, K.; Szalay, B.; Szalai, J.; Barna, I.; Gyires, K.; Verbeken, M.; Ronai, A.Z.
Intrathecally injected Ile-Pro-Ile, an inhibitor of membrane ectoenzyme dipeptidyl peptidase IV, is antihyperalgesic in rats by switching the enzyme from hydrolase to synthase functional mode to generate endomorphin 2
Eur. J. Pharmacol.
620
21-26
2009
Rattus norvegicus
Hung, T.T.; Wu, J.Y.; Liu, J.F.; Cheng, H.C.
Epitope analysis of the rat dipeptidyl peptidase IV monoclonal antibody 6A3 that blocks pericellular fibronectin-mediated cancer cell adhesion
FEBS J.
276
6548-6559
2009
Rattus norvegicus (P14740)
Yu, D.M.; Yao, T.W.; Chowdhury, S.; Nadvi, N.A.; Osborne, B.; Church, W.B.; McCaughan, G.W.; Gorrell, M.D.
The dipeptidyl peptidase IV family in cancer and cell biology
FEBS J.
277
1126-1144
2010
Homo sapiens (P27487)
Kotackova, L.; Balaziova, E.; Sedo, A.
Expression pattern of dipeptidyl peptidase IV activity and/or structure homologues in cancer
Folia Biol. (Praha)
55
77-84
2009
Homo sapiens
Cooper, K.G.; Woods, J.P.
Secreted dipeptidyl peptidase IV activity in the dimorphic fungal pathogen Histoplasma capsulatum
Infect. Immun.
77
2447-2454
2009
Histoplasma capsulatum
Jang, S.; Chung, T.Y.; Shin, J.; Lin, K.L.; Tzen, J.T.; Li, F.Y.
Docking study of the precursor peptide of matoparan onto its putative processing enzyme, dipeptidyl peptidase IV: a revisit to molecular ticketing
J. Comput. Aided Mol. Des.
24
213-224
2010
Homo sapiens
Kirino, Y.; Sato, Y.; Kamimoto, T.; Kawazoe, K.; Minakuchi, K.; Nakahori, Y.
Interrelationship of dipeptidyl peptidase IV (DPP4) with the development of diabetes, dyslipidaemia and nephropathy: A streptozotocin-induced model using wild-type and DPP4-deficient rats
J. Endocrinol.
200
53-61
2009
Rattus norvegicus
Al-masri, I.M.; Mohammad, M.K.; Tahaa, M.O.
Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine
J. Enzyme Inhib. Med. Chem.
24
1061-1066
2009
Homo sapiens (P27487), Homo sapiens
Maalouf, K.; Jia, J.; Rizk, S.; Brogden, G.; Keiser, M.; Das, A.; Naim, H.Y.
A modified lipid composition in Fabry disease leads to an intracellular block of the detergent-resistant membrane-associated dipeptidyl peptidase IV
J. Inherit. Metab. Dis.
33
445-449
2010
Homo sapiens
Diez-Torrubia, A.; Garcia-Aparicio, C.; Cabrera, S.; De Meester, I.; Balzarini, J.; Camarasa, M.J.; Velazquez, S.
Application of the dipeptidyl peptidase IV (DPPIV/CD26) based prodrug approach to different amine-containing drugs
J. Med. Chem.
53
559-572
2010
Bos taurus, Homo sapiens
Jiang, Y.K.
Molecular docking and 3D-QSAR studies on beta-phenylalanine derivatives as dipeptidyl peptidase IV inhibitors
J. Mol. Model.
16
1239-1249
2010
Homo sapiens (P27487)
Xu, F.; Corley, E.; Zacuto, M.; Conlon, D.A.; Pipik, B.; Humphrey, G.; Murry, J.; Tschaen, D.
Asymmetric synthesis of a potent, aminopiperidine-fused imidazopyridine dipeptidyl peptidase IV inhibitor
J. Org. Chem.
75
1343-1353
2010
Homo sapiens
Alponti, R.F.; Frezzatti, R.; Barone, J.M.; Alegre, V.D.; Silveira, P.F.
Dipeptidyl peptidase IV in the hypothalamus and hippocampus of monosodium glutamate obese and food-deprived rats
Metab. Clin. Exp.
60
234-242
2011
Rattus norvegicus (P14740)
Beesley, C.E.; Young, E.P.; Finnegan, N.; Jackson, M.; Mills, K.; Vellodi, A.; Cleary, M.; Winchester, B.G.
Discovery of a new biomarker for the mucopolysaccharidoses (MPS), dipeptidyl peptidase IV (DPP-IV; CD26), by SELDI-TOF mass spectrometry
Mol. Genet. Metab.
96
218-224
2009
Homo sapiens
Arscott, W.; LaBauve, A.; May, V.; Wesley, U.
Suppression of neuroblastoma growth by dipeptidyl peptidase IV: Relevance of chemokine regulation and caspase activation
Oncogene
28
479-491
2009
Rattus norvegicus
Fletcher, M.A.; Zeng, X.R.; Maher, K.; Levis, S.; Hurwitz, B.; Antoni, M.; Broderick, G.; Klimas, N.G.
Biomarkers in chronic fatigue syndrome: evaluation of natural killer cell function and dipeptidyl peptidase IV/CD26
PLoS ONE
5
e10817
2010
Homo sapiens
Merchant, M.; Mead, S.; McAdon, C.; McFatter, J.; Wasilewski, J.
Identification and characterization of dipeptidyl peptidase IV enzyme activity in the American crocodile (Crocodylus acutus)
Vet. Immunol. Immunopathol.
136
28-33
2010
Crocodylus acutus
Lawandi, J.; Toumieux, S.; Seyer, V.; Campbell, P.; Thielges, S.; Juillerat-Jeanneret, L.; Moitessier, N.
Constrained peptidomimetics reveal detailed geometric requirements of covalent prolyl oligopeptidase inhibitors
J. Med. Chem.
52
6672-6684
2009
Homo sapiens
Bar-Or, D.; Slone, D.S.; Mains, C.W.; Rael, L.T.
Dipeptidyl peptidase IV activity in commercial solutions of human serum albumin
Anal. Biochem.
441
13-17
2013
Homo sapiens
Juarez-Montiel, M.; Ibarra, J.A.; Chavez-Camarillo, G.; Hernandez-Rodriguez, C.; Villa-Tanaca, L.
Molecular cloning and heterologous expression in Pichia pastoris of X-prolyl-dipeptidyl aminopeptidase from basidiomycete Ustilago maydis
Appl. Biochem. Biotechnol.
172
2530-2539
2014
Ustilago maydis
Wu, W.; Liu, Y.; Milo, L.J.; Shu, Y.; Zhao, P.; Li, Y.; Woznica, I.; Yu, G.; Sanford, D.G.; Zhou, Y.; Poplawski, S.E.; Connolly, B.A.; Sudmeier, J.L.; Bachovchin, W.W.; Lai, J.H.
4-Substituted boro-proline dipeptides: synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities
Bioorg. Med. Chem. Lett.
22
5536-5540
2012
Homo sapiens
Lam, B.; Zhang, Z.; Stafford, J.A.; Skene, R.J.; Shi, L.; Gwaltney, S.L.
Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
22
6628-6631
2012
Homo sapiens (P27487)
Ikuma, Y.; Hochigai, H.; Kimura, H.; Nunami, N.; Kobayashi, T.; Uchiyama, K.; Umezome, T.; Sakurai, Y.; Sawada, N.; Tadano, J.; Sugaru, E.; Ono, M.; Hirose, Y.; Nakahira, H.
Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors: Use of a carboxylate prodrug to improve bioavailability
Bioorg. Med. Chem.
23
779-790
2015
Rattus norvegicus
Zhang, X.; Wang, J.; Su, M.; Li, Z.; Li, J.; Li, J.; Liu, H.
Discovering novel alpha-aminoacyl-containing proline derivatives with potent and selective inhibitory activity against dipeptidyl peptidase IV: design, synthesis, biological evaluation, and molecular modeling
Chem. Biol. Drug Des.
80
843-852
2012
Homo sapiens (P27487)
Sharma, M.; Singh, D.; Gupta, M.
Synthesis and evaluation of thiouracil derivatives as dipeptidyl peptidase IV inhibitors
Chem. Biol. Drug Des.
81
257-264
2013
Homo sapiens
Zhu, L.; Li, Y.; Qiu, L.; Su, M.; Wang, X.; Xia, C.; Qu, Y.; Li, J.; Li, J.; Xiong, B.; Shen, J.
Design and synthesis of 4-(2,4,5-trifluorophenyl)butane-1,3-diamines as dipeptidyl peptidase IV inhibitors
ChemMedChem
8
1104-1116
2013
Homo sapiens
Sato, K.; Nakamura, A.; Shirakawa, J.; Muraoka, T.; Togashi, Y.; Shinoda, K.; Orime, K.; Kubota, N.; Kadowaki, T.; Terauchi, Y.
Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance and beta-cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet
Endocrinology
153
1093-1102
2012
Mus musculus (P28843)
Li, Y.; Li, Z.; Zhang, J.
Dipeptidyl peptidase IV reduces trophoblast invasion by inhibiting the activity of MMPs
Int. J. Dev. Biol.
58
349-353
2014
Homo sapiens (P27487), Homo sapiens
Gomez, H.; Chappe, M.; Valiente, P.A.; Pons, T.; Chavez, M.d.e..L.; Charli, J.L.; Pascual, I.
Effect of zinc and calcium ions on the rat kidney membrane-bound form of dipeptidyl peptidase IV
J. Biosci.
38
461-469
2013
Rattus norvegicus
Herlihy, S.E.; Pilling, D.; Maharjan, A.S.; Gomer, R.H.
Dipeptidyl peptidase IV is a human and murine neutrophil chemorepellent
J. Immunol.
190
6468-6477
2013
Homo sapiens, Mus musculus
Röhnert, P.; Schmidt, W.; Emmerlich, P.; Goihl, A.; Wrenger, S.; Bank, U.; Nordhoff, K.; Täger, M.; Ansorge, S.; Reinhold, D.; Striggow, F.
Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia
J. Neuroinflammation
9
44
2012
Rattus norvegicus
Sharoyan, S.; Antonyan, A.; Mardanyan, S.; Harutyunyan, H.; Movsisyan, N.; Hovnanyan, N.; Hovnanyan, K.
Interaction of dipeptydil peptidase IV with amyloid peptides
Neurochem. Int.
62
1048-1054
2013
Bos taurus
Dimitrova, M.; Ivanov, I.; Todorova, R.; Stefanova, N.; Moskova-Doumanova, V.; Topouzova-Hristova, T.; Saynova, V.; Stephanova, E.
Comparison of the activity levels and localization of dipeptidyl peptidase IV in normal and tumor human lung cells
Tissue Cell
44
74-79
2012
Homo sapiens
Fteita, D.; Musrati, A.A.; Koenoenen, E.; Ma, X.; Guersoy, M.; Peurla, M.; Soederling, E.; Sintim, H.O.; Guersoy, U.K.
Dipeptidyl peptidase IV and quorum sensing signaling in biofilm-related virulence of Prevotella aurantiaca
Anaerobe
48
152-159
2017
Prevotella aurantiaca
Lee, H.K.; Kim, M.K.; Kim, H.D.; Kim, H.J.; Kim, J.W.; Lee, J.O.; Kim, C.W.; Kim, E.E.
Unique binding mode of evogliptin with human dipeptidyl peptidase IV
Biochem. Biophys. Res. Commun.
494
452-459
2017
Homo sapiens (P27487), Homo sapiens
Ran, Y.; Pei, H.; Shao, M.; Chen, L.
Synthesis, biological evaluation, and molecular docking of (R)-2-((8-(3-aminopiperidin-1-yl)-3-methyl-7-(3-methylbut-2-en-1-yl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)methyl)benzonitrile as dipeptidyl peptidase IV inhibitors
Chem. Biol. Drug Des.
87
290-295
2016
Homo sapiens (P27487), Homo sapiens
Xing, J.; Gong, Q.; Zhang, R.; Sun, S.; Zou, R.; Wu, A.
A novel non-enzymatic hydrolytic probe for dipeptidyl peptidase IV specific recognition and imaging
Chem. Commun. (Camb.)
54
8773-8776
2018
Homo sapiens (P27487)
Zhang, Y.; Liu, H.; Hong, H.; Luo, Y.
Purification and identification of dipeptidyl peptidase IV and angiotensin-converting enzyme inhibitory peptides from silver carp (Hypophthalmichthys molitrix) muscle hydrolysate
Eur. Food Res. Technol.
245
243-255
2019
Homo sapiens
-
Arisoy, S.; Uestuen-Aytekin, O.
Hydrolysis of food-derived opioids by dipeptidyl peptidase IV from Lactococcus lactis spp. lactis
Food Res. Int.
111
574-581
2018
Lactococcus lactis ssp. lactis
Busek, P.; Hrabal, P.; Fric, P.; Sedo, A.
Co-expression of the homologous proteases fibroblast activation protein and dipeptidyl peptidase-IV in the adult human Langerhans islets
Histochem. Cell Biol.
143
497-504
2015
Homo sapiens (P27487)
-
Pereira, A.L.E.; Dos Santos, G.B.; Franco, M.S.F.; Federico, L.B.; da Silva, C.H.T.P.; Santos, C.B.R.
Molecular modeling and statistical analysis in the design of derivatives of human dipeptidyl peptidase IV
J. Biomol. Struct. Dyn.
36
318-334
2018
Homo sapiens (P27487), Homo sapiens
Frenssen, F.; Croonenberghs, J.; Van den Steene, H.; Maes, M.
Prolyl endopeptidase and dipeptidyl peptidase IV are associated with externalizing and aggressive behaviors in normal and autistic adolescents
Life Sci.
136
157-162
2015
Homo sapiens (P27487), Homo sapiens
Neidert, L.; Al-Tarhuni, M.; Goldman, D.; Kluess, H.; Jackson, D.
Endogenous dipeptidyl peptidase IV modulates skeletal muscle arteriolar diameter in rats
Physiol. Rep.
6
e13564
2018
Rattus norvegicus (P14740)
Roppongi, S.; Suzuki, Y.; Tateoka, C.; Fujimoto, M.; Morisawa, S.; Iizuka, I.; Nakamura, A.; Honma, N.; Shida, Y.; Ogasawara, W.; Tanaka, N.; Sakamoto, Y.; Nonaka, T.
Crystal structures of a bacterial dipeptidyl peptidase IV reveal a novel substrate recognition mechanism distinct from that of mammalian orthologues
Sci. Rep.
8
2714
2018
Pseudoxanthomonas mexicana (Q6F3I7)
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