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benzyloxyarbonyl-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Gly L-Pro-L-Arg + 7-amino-4-methylcoumarin
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benzyloxycarbonyl-L-Leu-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Leu-L-Arg + 7-amino-4-methylcoumarin
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benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
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beta-(2-thienyl)Ala-beta-(7-methoxycoumarin-4-yl)Ala-Ser-Gln-Tyr(3-NO2)-NH2 + H2O
beta-(2-thienyl)Ala-beta-(7-methoxycoumarin-4-yl)Ala + Ser-Gln-Tyr(3-NO2)-NH2
specific and selective substrate
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?
beta-(2-thienyl)Ala-beta-(7-methoxycoumarin-4-yl)Ala-Ser-Gly-Tyr(3-NO2)-NH2 + H2O
beta-(2-thienyl)Ala-beta-(7-methoxycoumarin-4-yl)Ala + Ser-Gly-Tyr(3-NO2)-NH2
specific and selective substrate
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?
beta-(2-thienyl)Ala-beta-(7-methoxycoumarin-4-yl)Ala-Ser-Tyr(3-NO2)-NH2 + H2O
beta-(2-thienyl)Ala-beta-(7-methoxycoumarin-4-yl)Ala + Ser-Tyr(3-NO2)-NH2
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beta-(2-thienyl)Ala-Phe-7-amido-4-methylcoumarin + H2O
beta-(2-thienyl)Ala-Phe + 7-amino-4-methylcoumarin
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Gly-Phe-7-amido-4-methylcoumarin + H2O
Gly-Phe + 7-amino-4-methylcoumarin
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t-butyloxycarbonyl-L-Val-L-Leu-L-Lys-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-L-Val-L-Leu-Lys + 7-amino-4-methylcoumarin
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?
(H2N-Abu-Homo-Phe)2-rhodamine + H2O
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assay at pH 5.5, 37°C
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(H2N-fulleroproline-Homo-Phe)2-rhodamine + H2O
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assay at pH 5.5, 37°C
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(H2N-Leu-Homo-Phe)2-rhodamine + H2O
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assay at pH 5.5, 37°C
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(H2N-Leu-Leu)2-rhodamine + H2O
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assay at pH 5.5, 37°C
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(H2N-Nva-(4-phenyl)Phe)2-rhodamine + H2O
?
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assay at pH 5.5, 37°C
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(H2N-Nva-Homo-Phe)2-rhodamine + H2O
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assay at pH 5.5, 37°C
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(H2N-Pro-Homo-Phe)2-rhodamine + H2O
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assay at pH 5.5, 37°C
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benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O
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Gly-Arg-4-methylcoumarin 7-amide + H2O
Gly-Arg + 7-amino-4-methylcoumarin
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?
Gly-L-Arg-7-amido-4-methylcoumarin + H2O
Gly-L-Arg + 7-amino-4-methylcoumarin
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?
Gly-Phe-2-naphthylamide + H2O
Gly-Phe + 2-naphthylamine
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?
Gly-Phe-4-methoxy-2-naphthylamide + H2O
Gly-Phe + 4-methoxy-2-naphthylamine
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?
Gly-Phe-7-amido-4-methylcoumarin + H2O
Gly-Phe + 7-amino-4-methylcoumarin
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assay at pH 5.5, 37°C
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?
Gly-Tyr(3'NO2)-Gly-Pro-Pro-Lys(epsilon-(2-aminobenzoyl))-Gly + H2O
Gly-Tyr(3'NO2) + Gly-Pro-Pro-Lys(epsilon-(2-aminobenzoyl))-Gly
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?
H2N-Abu-(4-phenyl)Phe-rhodamine-morpholine-4-carboxamide + H2O
?
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assay at pH 5.5, 37°C
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H2N-Abu-Homo-Phe-rhodamine-morpholine-4-carboxamide + H2O
?
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assay at pH 5.5, 37°C
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H2N-fulleroproline-(3-methyl)Phe-rhodamine-morpholine-4-carboxamide + H2O
?
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assay at pH 5.5, 37°C
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?
H2N-fulleroproline-(4-phenyl)Phe-rhodamine-morpholine-4-carboxamide + H2O
?
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assay at pH 5.5, 37°C
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?
H2N-Leu-(3-methyl)Phe-rhodamine-morpholine-4-carboxamide + H2O
?
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assay at pH 5.5, 37°C
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?
H2N-Nva-(3-methyl)Phe-rhodamine-morpholine-4-carboxamide + H2O
?
-
assay at pH 5.5, 37°C
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?
L-Ser-L-Tyr-7-amido-4-methylcoumarin + H2O
L-Ser-L-Tyr + 7-amino-4-methylcoumarin
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Pro-Phe-NH2 + H2O
Pro-Phe + NH3
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additional information
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additional information
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enzyme is involved in intracellular degradation of proteins
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additional information
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enzyme is involved in intracellular degradation of proteins
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additional information
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loss of DPPI activity in patients with Papillon-Lefevre syndrome is associated with severe reduction in the activity and stability of neutrophil-derived serine proteases
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additional information
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loss of DPPI activity in patients with Papillon-Lefevre syndrome is associated with severe reduction in the activity and stability of neutrophil-derived serine proteases
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additional information
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substrates with blocked amino-termini, with Pro at the P1 position, Arg at the P2, or containing only single amino acids are not hydrolyzed
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additional information
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modest preference for peptides with nonpolar residues in the P1 position
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additional information
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,n high affinity interaction between heparin and prochymase allows the 2 residue propeptide to be cleaved by dipeptidylpeptidase I
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additional information
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together with other proteases the enzyme plays a major part in degradation of ingested substances after endocytosis and in tissue damage following enzyme release
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additional information
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the enzyme plays a requisite role in the post-translational processing and activation of members of the family of granule serine proteases expressed in bone marrow-derived effector cells
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additional information
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cathepsin C is required for granzyme B activation in unstimulated human natural killer cells. However in vitro activation of Papillon-Lefevre syndrome natural killer cells with interleukin-2 restores cytolytic function and granzyme B activity by a cathepsin C-independent mechanism
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additional information
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mutation in the cathepsin C gene are not the cause of all early-onset periodontal disease, and currently there is no evidence for the existence of a class of patients who do not have the full Papillon-Lefevre syndrome disease phenotype, but suffer isolated aggressive periodontitis because they have a low-activity cathepsin C gene variant
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additional information
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Papillon-Lefèvre syndrome is a rare autosomal recessive disease that involves severe periodontitis and hyperkeratosis of the hand palms and foot soles. Gene analysis of the CTSC gene in two families with Papillon-Lefèvre syndrome demonstrates that in the patients with Papillon-Lefèvre syndrome the absence of cathepsin C activity coincides with absence of activity of the serine proteinases elastase, cathepsin G and proteinase 3
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additional information
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the enzyme may play a role in converting the endogenous beta-MSH(5-22) to more potent peptides that regulate energy homeostasis in the hypothalamus
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additional information
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cathepsin C has a broad substrate specificity being able to hydrolyse out nearly every possible dipeptide unit, with the exception of those containing basic amino acids (Arg or Lys) at N-terminal position or Pro on either side of the scissile bond
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Acro-Osteolysis
New syndrome of hypotrichosis, striate palmoplantar keratoderma, acro-osteolysis and periodontitis not due to mutations in cathepsin C.
Adenocarcinoma
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus.
Adenocarcinoma
[Modern esophageal surgery and late functional results as equations with several unknowns--Hungarian Academy of Sciences Doctoral Thesis]
Adenocarcinoma of Lung
Cysteine proteases and cysteine protease inhibitors in non-small cell lung cancer.
Aggressive Periodontitis
Cathepsin C gene 5'-untranslated region mutation in papillon-lefèvre syndrome.
Aggressive Periodontitis
Cathepsin C gene variants in aggressive periodontitis.
Aggressive Periodontitis
Confirmation of oxidative stress and fatty acid disturbances in two further Papillon-Lefèvre syndrome families with identification of a new mutation.
Aggressive Periodontitis
Dermatologic, periodontal, and skeletal manifestations of Haim-Munk syndrome in two siblings.
Aggressive Periodontitis
Functional Cathepsin C mutations cause different Papillon-Lefèvre syndrome phenotypes.
Aggressive Periodontitis
Haim-Munk syndrome.
Aggressive Periodontitis
Identification of cathepsin C mutations in ethnically diverse papillon-Lefèvre syndrome patients.
Aggressive Periodontitis
Identification of genetic risk factors for periodontitis and possible mechanisms of action.
Aggressive Periodontitis
Localisation of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutation.
Aggressive Periodontitis
Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome.
Aggressive Periodontitis
Novel mutations in the cathepsin C gene in patients with pre-pubertal aggressive periodontitis and Papillon-Lefèvre syndrome.
Aggressive Periodontitis
Structure of the periodontium in cathepsin C-deficient mice.
Aggressive Periodontitis
The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis.
Anaphylaxis
Biomarkers in Human Anaphylaxis: A Critical Appraisal of Current Evidence and Perspectives.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
The Synthesis of ?,?-Disubstituted ?-Amino Acids via Ichikawa Rearrangement.
Aortic Aneurysm, Abdominal
Critical role of dipeptidyl peptidase I in neutrophil recruitment during the development of experimental abdominal aortic aneurysms.
Aortic Aneurysm, Abdominal
Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation.
Aortic Aneurysm, Abdominal
Role of cathepsin C in elastase-induced mouse abdominal aortic aneurysms.
Arrhythmias, Cardiac
Electrophysiological and Anatomical Correlates of Sites With Postpacing Intervals Shorter Than Tachycardia Cycle Length in Atypical Atrial Flutter.
Arthritis
Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis.
Arthritis
Liposomes encapsulated dimethyl curcumin regulates dipeptidyl peptidase I activity, gelatinase release and cell cycle of spleen lymphocytes in-vivo to attenuate collagen induced arthritis in rats.
Arthritis
Serum based fluorescent assay for evaluating dipeptidyl peptidase I activity in collagen induced arthritis rat model.
Arthritis, Experimental
Dipeptidyl peptidase I regulates the development of collagen-induced arthritis.
Arthritis, Experimental
Serum based fluorescent assay for evaluating dipeptidyl peptidase I activity in collagen induced arthritis rat model.
Arthritis, Rheumatoid
Lysosomal peptidases and glycosidases in rheumatoid arthritis.
Arthritis, Rheumatoid
The regulatory role of Dipeptidyl peptidase I on the activation of immune granulocytes.
Aspergillosis
Antifungal Treatments Delineate a Correlation between Cathepsins and Cytokines in Murine Model of Invasive Aspergillosis.
Asthma
Dipeptidyl peptidase I cleaves matrix-associated proteins and is expressed mainly by mast cells in normal dog airways.
Asthma
Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to sendai virus infection.
Asthma
Gene expression profiling in human asthma.
Asthma
Identification of an alternative splicing variant of cathepsin C/dipeptidyl-peptidase I.
Asthma
Neutrophil Extracellular Traps Enhance Early Inflammatory Response in Sendai Virus-Induced Asthma Phenotype.
Atherosclerosis
Leukocyte cathepsin C deficiency attenuates atherosclerotic lesion progression by selective tuning of innate and adaptive immune responses.
Atrial Flutter
Electrophysiological and Anatomical Correlates of Sites With Postpacing Intervals Shorter Than Tachycardia Cycle Length in Atypical Atrial Flutter.
Autoimmune Diseases
Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy.
Autoimmune Diseases
Identification and Optimization of Novel Cathepsin C Inhibitors Derived from EGFR Inhibitors.
Autoimmune Diseases
Therapeutic utility and medicinal chemistry of cathepsin C inhibitors.
Bacterial Infections
Mast cell dipeptidyl peptidase I mediates survival from sepsis.
Blister
Acid hydrolases in blister fluid. 3. Characterization and quantification of peptide hydrolases.
Breast Neoplasms
Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation.
Breast Neoplasms
Neutrophils create a fertile soil for metastasis.
Bronchiectasis
Cathepsin C inhibitors as anti-inflammatory drug discovery: Challenges and opportunities.
Bronchiectasis
The Synthesis of ?,?-Disubstituted ?-Amino Acids via Ichikawa Rearrangement.
Carcinogenesis
Cathepsin C is a tissue-specific regulator of squamous carcinogenesis.
Carcinoma
Cysteine proteases and cysteine protease inhibitors in non-small cell lung cancer.
Carcinoma
Expression of angiopoietin-like 4 and tenascin C but not cathepsin C mRNA predicts prognosis of oral tongue squamous cell carcinoma.
Carcinoma
Lysosomal dipeptidyl-peptidases I and II in human squamous cell lung carcinoma and lung parenchyma.
Carcinoma, Hepatocellular
Cathepsin C Interacts with TNF-?/p38 MAPK Signaling Pathway to Promote Proliferation and Metastasis in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Synthesis, transport and processing of cathepsin C in Morris hepatoma 7777 cells and rat hepatocytes.
Carcinoma, Papillary
Increase of endo-peptidases and exo-peptidases in thyroid-tumors.
Carcinoma, Renal Cell
Timosaponin AIII inhibits metastasis of renal carcinoma cells through suppressing cathepsin C expression by AKT/miR-129-5p axis.
Carcinoma, Squamous Cell
Expression of angiopoietin-like 4 and tenascin C but not cathepsin C mRNA predicts prognosis of oral tongue squamous cell carcinoma.
cathepsin l deficiency
Epidermal differentiation: the role of proteases and their inhibitors.
Cholesteatoma
Gene expression analysis of human middle ear cholesteatoma using complementary DNA arrays.
Colonic Neoplasms
Effect of short-chain fatty acids on the proliferation and differentiation of the human colonic adenocarcinoma cell line Caco-2.
Colorectal Neoplasms
In vitro and in vivo studies on potentiation of curcumin-induced lysosomal-dependent apoptosis upon silencing of cathepsin C in colorectal cancer cells.
Colorectal Neoplasms
Targeting of cathepsin C induces autophagic dysregulation that directs ER stress mediated cellular cytotoxicity in colorectal cancer cells.
Coronary Artery Disease
Digital arterial pressure pulse wave analysis and cardiovascular events in the general population: the Prevention of Renal and Vascular End-stage Disease study.
COVID-19
Cathepsin C inhibitors as anti-inflammatory drug discovery: Challenges and opportunities.
COVID-19
Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS?
Cystic Fibrosis
Inhibitors of cathepsin C (dipeptidyl peptidase I).
Cystic Fibrosis
The Synthesis of ?,?-Disubstituted ?-Amino Acids via Ichikawa Rearrangement.
Cysts
The activity of a developmentally regulated cysteine proteinase is required for cyst wall formation in the primitive eukaryote Giardia lamblia.
Demyelinating Diseases
Cathepsin C modulates myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.
Demyelinating Diseases
Correction: Disinhibition of Cathepsin C Caused by Cystatin F Deficiency Aggravates the Demyelination in a Cuprizone Model.
Demyelinating Diseases
Disinhibition of Cathepsin C Caused by Cystatin F Deficiency Aggravates the Demyelination in a Cuprizone Model.
Demyelinating Diseases
The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model.
Diabetes Mellitus
Inflammatory Serine Proteases Play a Critical Role in the Early Pathogenesis of Diabetic Cardiomyopathy.
Diabetes Mellitus, Type 1
Inflammatory Serine Proteases Play a Critical Role in the Early Pathogenesis of Diabetic Cardiomyopathy.
dipeptidyl-peptidase i deficiency
Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants.
dipeptidyl-peptidase i deficiency
Characterization of neutrophil function in Papillon-Lefèvre syndrome.
dipeptidyl-peptidase i deficiency
Leukocyte cathepsin C deficiency attenuates atherosclerotic lesion progression by selective tuning of innate and adaptive immune responses.
dipeptidyl-peptidase i deficiency
Nemaline myopathy. Evidence of dipeptidyl peptidase I deficiency.
dipeptidyl-peptidase i deficiency
NSP4 Is Stored in Azurophil Granules and Released by Activated Neutrophils as Active Endoprotease with Restricted Specificity.
dipeptidyl-peptidase i deficiency
Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans.
dipeptidyl-peptidase i deficiency
Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis.
dipeptidyl-peptidase i deficiency
Structure of the periodontium in cathepsin C-deficient mice.
Ectodermal Dysplasia
Diagnosis of Papillon-Lefèvre syndrome: review of the literature and a case report.
Ectromelia
Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis.
Encephalomyelitis
Cathepsin C modulates myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Cathepsin C modulates myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.
Enteritis
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.
Enterocolitis, Necrotizing
Human breast milk oligosaccharides attenuate necrotizing enterocolitis in rats by suppressing mast cell accumulation, DPPI activity and TLR4 expression in ileum tissue, and regulating mitochondrial damage of Caco-2 cells.
Genetic Diseases, Inborn
Cu-sil dentures: A novel approach of Papillon-Lefèvre syndrome management.
Gingivitis
A novel mutation in the cathepsin C gene in a Pakistani family with Papillon-Lefevre syndrome.
Gingivitis
[Papillon-Lefèvre syndrome: A new case].
Glioma
Intravascular streaming during carotid artery infusions. Demonstration in humans and reduction using diastole-phased pulsatile administration.
Glomerulonephritis, Membranous
Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis.
Granulomatosis with Polyangiitis
Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).
Heart Failure
Digital arterial pressure pulse wave analysis and cardiovascular events in the general population: the Prevention of Renal and Vascular End-stage Disease study.
Hyperglycemia
Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia.
Hypertension
Hydrolase activities in the rat aorta. II. Effects of hypertension alone and in combination with diabetes mellitus.
Hypotrichosis
New syndrome of hypotrichosis, striate palmoplantar keratoderma, acro-osteolysis and periodontitis not due to mutations in cathepsin C.
Infections
Abrogation of cathepsin C by Helicobacter pylori impairs neutrophil activation to promote gastric infection.
Infections
Cathepsin Cs are key for the intracellular survival of the protozoan parasite, Toxoplasma gondii.
Infections
Characterization of cathepsin C from orange-spotted grouper, Epinephelus coioides involved in SGIV infection.
Infections
Dipeptidyl peptidase I controls survival from Klebsiella pneumoniae lung infection by processing surfactant protein D.
Infections
Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis.
Infections
Papillon-Lefévre syndrome: a highly-suspected case.
Joint Diseases
Serum based fluorescent assay for evaluating dipeptidyl peptidase I activity in collagen induced arthritis rat model.
Keratoderma, Palmoplantar
A novel mutation in the cathepsin C gene in a Pakistani family with Papillon-Lefevre syndrome.
Keratoderma, Palmoplantar
Cathepsin C gene 5'-untranslated region mutation in papillon-lefèvre syndrome.
Keratoderma, Palmoplantar
Cathepsin C gene: First compound heterozygous patient with Papillon-Lefèvre syndrome and a novel symptomless mutation.
Keratoderma, Palmoplantar
Demonstration of altered splicing with the IVS3-1G --> a mutation of cathepsin C.
Keratoderma, Palmoplantar
Identification of a novel cathepsin C mutation (p.W185X) in a Brazilian kindred with Papillon-Lefèvre syndrome.
Keratoderma, Palmoplantar
Identification of cathepsin C mutations in ethnically diverse papillon-Lefèvre syndrome patients.
Keratoderma, Palmoplantar
Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis.
Keratoderma, Palmoplantar
New syndrome of hypotrichosis, striate palmoplantar keratoderma, acro-osteolysis and periodontitis not due to mutations in cathepsin C.
Keratoderma, Palmoplantar
Papillon-Lefèvre syndrome (PLS) with novel compound heterozygous mutation in the exclusion and Peptidase C1A domains of Cathepsin C gene.
Keratoderma, Palmoplantar
The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis.
Keratosis
Confirmation of oxidative stress and fatty acid disturbances in two further Papillon-Lefèvre syndrome families with identification of a new mutation.
Liver Diseases
[Characteristics of bleeding from esophageal-gastric varices in patients with HIV infection]
Liver Neoplasms, Experimental
Synthesis, transport and processing of cathepsin C in Morris hepatoma 7777 cells and rat hepatocytes.
Liver Neoplasms, Experimental
Transient membrane association of the precursors of cathepsin C during their transfer into lysosomes.
Lung Diseases
Dipeptidyl peptidase I cleaves matrix-associated proteins and is expressed mainly by mast cells in normal dog airways.
Lung Diseases
Neutrophilic cathepsin C is maturated by a multi-step proteolytic process and secreted by activated cells during inflammatory lung diseases.
Lymphatic Metastasis
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus.
Malaria
Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes.
Malaria
Plasmodium dipeptidyl aminopeptidases as malaria transmission-blocking drug targets.
Mastocytoma
Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I.
Mastocytoma
Regulated expression, processing, and secretion of dog mast cell dipeptidyl peptidase I.
Muscular Dystrophies
Decreased lysosomal dipeptidyl aminopeptidase I activity in cultured human skin fibroblasts in Duchenne's muscular dystrophy.
Muscular Dystrophy, Duchenne
Dipeptidyl peptidase I in cultured fibroblasts in Duchenne muscular dystrophy.
Myocardial Infarction
Meta-Analysis of the Cardiovascular Outcomes with Dipeptidyl Peptidase 4 Inhibitors: Validation of the Current FDA Mandate.
Myopathies, Nemaline
Nemaline myopathy. Evidence of dipeptidyl peptidase I deficiency.
Neoplasm Metastasis
Cathepsin C Interacts with TNF-?/p38 MAPK Signaling Pathway to Promote Proliferation and Metastasis in Hepatocellular Carcinoma.
Neoplasm Metastasis
Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation.
Neoplasm Metastasis
Neutrophils create a fertile soil for metastasis.
Neoplasm Metastasis
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus.
Neoplasm Metastasis
Timosaponin AIII inhibits metastasis of renal carcinoma cells through suppressing cathepsin C expression by AKT/miR-129-5p axis.
Neoplasms
Cathepsin C Interacts with TNF-?/p38 MAPK Signaling Pathway to Promote Proliferation and Metastasis in Hepatocellular Carcinoma.
Neoplasms
Demonstration of proteases in basal cell carcinomas. A histochemical study using amino acid-4-methoxy-2-naphthylamides as chromogenic substrates.
Neoplasms
Distinct roles for cysteine cathepsin genes in multistage tumorigenesis.
Neoplasms
Expression of the interleukin-4 receptor alpha in human conjunctival epithelial cells.
Neoplasms
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus.
Neoplasms
Simultaneous expression of Cathepsins B and K in pulmonary adenocarcinomas and squamous cell carcinomas predicts poor recurrence-free and overall survival.
Neoplasms
Spectrum of toxicities of amino acid methyl esters for myeloid cells is determined by distinct metabolic pathways.
Neoplasms
Targeting of cathepsin C induces autophagic dysregulation that directs ER stress mediated cellular cytotoxicity in colorectal cancer cells.
Neoplasms
The production of tumour necrosis factor, tissue thromboplastin, lactoferrin and cathepsin C during lipopolysaccharide stimulation in whole blood.
Neoplasms
[Modern esophageal surgery and late functional results as equations with several unknowns--Hungarian Academy of Sciences Doctoral Thesis]
Nephritis, Interstitial
Identification and characterization of the interactive proteins with cytotoxic T-lymphocyte antigen-2?
Nephrosis, Lipoid
Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis.
Nervous System Diseases
Disinhibition of Cathepsin C Caused by Cystatin F Deficiency Aggravates the Demyelination in a Cuprizone Model.
Netherton Syndrome
Epidermal differentiation: the role of proteases and their inhibitors.
Neurodegenerative Diseases
Dipeptidyl-peptidase I does not functionally compensate for the loss of tripeptidyl-peptidase I in the neurodegenerative disease late-infantile neuronal ceroid lipofuscinosis.
Neuroinflammatory Diseases
Cathepsin C Aggravates Neuroinflammation Involved in Disturbances of Behaviour and Neurochemistry in Acute and Chronic Stress-Induced Murine Model of Depression.
Neuroinflammatory Diseases
Cathepsin C aggravates neuroinflammation via promoting production of CCL2 and CXCL2 in glial cells and neurons in a cryogenic brain lesion.
Neuroinflammatory Diseases
Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca2+-dependent PKC/p38MAPK/NF-?B pathway.
Neuroinflammatory Diseases
Correction to: Cathepsin C Aggravates Neuroinflammation Involved in Disturbances of Behaviour and Neurochemistry in Acute and Chronic Stress-Induced Murine Model of Depression.
Neuroinflammatory Diseases
Up-regulation of microglial cathepsin C expression and activity in lipopolysaccharide-induced neuroinflammation.
Neuronal Ceroid-Lipofuscinoses
Dipeptidyl-peptidase I does not functionally compensate for the loss of tripeptidyl-peptidase I in the neurodegenerative disease late-infantile neuronal ceroid lipofuscinosis.
Pancreatic Neoplasms
The iron-regulated metastasis suppressor, Ndrg-1: Identification of novel molecular targets.
Pancreatitis
Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin.
Papillon-Lefevre Disease
A family with Papillon-Lefevre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity.
Papillon-Lefevre Disease
A homozygous cathepsin C mutation associated with Haim-Munk syndrome.
Papillon-Lefevre Disease
A novel mutation in the cathepsin C (CTSC) gene in Iranian family with Papillon-Lefevre syndrome.
Papillon-Lefevre Disease
A novel mutation in the cathepsin C gene in a Pakistani family with Papillon-Lefevre syndrome.
Papillon-Lefevre Disease
A novel mutation of the cathepsin C gene in a thai family with Papillon-Lefevre syndrome.
Papillon-Lefevre Disease
Cathepsin C involvement in the aetiology of Papillon-Lefevre syndrome.
Papillon-Lefevre Disease
Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease.
Papillon-Lefevre Disease
Epidermal differentiation: the role of proteases and their inhibitors.
Papillon-Lefevre Disease
Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans.
Papillon-Lefevre Disease
Papillon-Lefèvre syndrome (PLS) with novel compound heterozygous mutation in the exclusion and Peptidase C1A domains of Cathepsin C gene.
Papillon-Lefevre Disease
Papillon-Lefevre syndrome (PLS) without cathepsin C mutation: A rare early onset partially penetrant variant of PLS.
Papillon-Lefevre Disease
Papillon-lefevre syndrome.
Papillon-Lefevre Disease
Papillon-Lefevre syndrome: A report of two cases.
Papillon-Lefevre Disease
Structure of the periodontium in cathepsin C-deficient mice.
Papillon-Lefevre Disease
Whole-exome sequencing reveals a recurrent mutation in the cathepsin C gene that causes Papillon-Lefevre syndrome in a Saudi family.
Papillon-Lefevre Disease
[Mutational analysis of the cathepsin C gene in a family of Han nationality with Papillon-Lefevre syndrome.]
Paralysis
Proteolytic enzymes in ordinary, hyperacute, monocytic and passive transfer forms of experimental allergic encephalomyelitis.
Pemphigoid, Bullous
Dipeptidyl peptidase-4 inhibitors and bullous pemphigoid: A systematic review and adjusted meta-analysis.
Periodontal Diseases
Are proteinase 3 and cathepsin C enzymes related to pathogenesis of periodontitis?
Periodontal Diseases
Cathepsin C gene: First compound heterozygous patient with Papillon-Lefèvre syndrome and a novel symptomless mutation.
Periodontal Diseases
Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis.
Periodontal Diseases
Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis.
Periodontal Diseases
Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome.
Periodontitis
Characterization of neutrophil function in Papillon-Lefèvre syndrome.
Periodontitis
Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease.
Periodontitis
Identification of cathepsin C mutations in ethnically diverse papillon-Lefèvre syndrome patients.
Periodontitis
Identification of putative genetic modifying factors that influence the development of Papillon-Lefévre or Haim-Munk syndrome phenotypes.
Periodontitis
Mutation analysis of cathepsin C gene in a Chinese patient with pre-pubertal periodontitis.
Periodontitis
Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome.
Periodontitis
New syndrome of hypotrichosis, striate palmoplantar keratoderma, acro-osteolysis and periodontitis not due to mutations in cathepsin C.
Periodontitis
Papillon-Lefèvre syndrome (PLS) with novel compound heterozygous mutation in the exclusion and Peptidase C1A domains of Cathepsin C gene.
Periodontitis
Papillon-Lefèvre Syndrome with Homozygous Nonsense Mutation of Cathepsin C Gene Presenting with Late-Onset Periodontitis.
Periodontitis
Papillon-Lefevre syndrome: clinical presentation and a brief review.
Periodontitis
Potential Role of the Mitochondria for the Dermatological Treatment of Papillon-Lefèvre.
Periodontitis
Role of polymorphonuclear leukocyte-derived serine proteinases in defense against Actinobacillus actinomycetemcomitans.
Periodontitis
The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis.
Peritonitis
Dipeptidyl peptidase I controls survival from Klebsiella pneumoniae lung infection by processing surfactant protein D.
Pre-Eclampsia
Upregulation of cathepsin C expression contributes to endothelial chymase activation in preeclampsia.
Primary Graft Dysfunction
Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation.
Proteinuria
[Peptidases in the kidney of male rats following castration and testosterone substitution]
Pulmonary Disease, Chronic Obstructive
Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy.
Pulmonary Disease, Chronic Obstructive
Discovery and In Vivo Anti-inflammatory Activity Evaluation of a Novel Non-peptidyl Non-covalent Cathepsin C Inhibitor.
Pulmonary Disease, Chronic Obstructive
Inhibitors of cathepsin C (dipeptidyl peptidase I).
Respiratory Distress Syndrome
Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy.
Sepsis
Mast cell dipeptidyl peptidase I mediates survival from sepsis.
Squamous Cell Carcinoma of Head and Neck
Expression of angiopoietin-like 4 and tenascin C but not cathepsin C mRNA predicts prognosis of oral tongue squamous cell carcinoma.
Stomach Neoplasms
Decursin inhibits cell growth and autophagic flux in gastric cancer via suppression of cathepsin C.
Stroke
Meta-Analysis of the Cardiovascular Outcomes with Dipeptidyl Peptidase 4 Inhibitors: Validation of the Current FDA Mandate.
Toxoplasmosis
Cathepsin Cs are key for the intracellular survival of the protozoan parasite, Toxoplasma gondii.
Toxoplasmosis
DNA Vaccines Encoding Toxoplasma gondii Cathepsin C 1 Induce Protection against Toxoplasmosis in Mice.
Vasculitis
Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis.
Virus Diseases
Cathepsin C limits acute viral infection independently of NK cell and CD8(+) T-cell cytolytic function.
Virus Diseases
Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to sendai virus infection.
Virus Diseases
Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis.
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Mantle, D.
Characterization of dipeptidyl and tripeptidyl aminopeptidases in human kidney soluble fraction
Clin. Chim. Acta
196
135-142
1991
Homo sapiens
brenda
Popovic, T.; Puizdar, V.; Ritonja, A.; Brzin, J.
Simultaneous isolation of human kidney cathepsins B, H, L and C and their characterisation
J. Chromatogr.
681
251-262
1996
Homo sapiens
brenda
Rao, N.V.; Rao, G.V.; Hoidal, J.R.
Human dipeptidyl-peptidase I. Gene characterization, localization, and expression
J. Biol. Chem.
272
10260-10265
1997
Homo sapiens (P53634), Homo sapiens
brenda
Davies, P.; Allison, A.C.; Hylton, W.J.
The identification, properties and subcellular distribution of cathepsins B1 and C (dipeptidyl aminopeptidase 1) in human peripheral-blood leucocytes
Biochem. Soc. Trans.
2
432-434
1974
Homo sapiens
-
brenda
Cigic, B.; Pain, R.H.
Competitive inhibition of cathepsin C by guanidinium ions and reexamination of substrate inhibition
Biochem. Biophys. Res. Commun.
258
6-10
1999
Homo sapiens
brenda
McGuire, M.J.; Lipsky, P.E.; Thiele, D.L.
Purification and characterization of dipeptidyl peptidase I from human spleen
Arch. Biochem. Biophys.
295
280-288
1992
Homo sapiens
brenda
McGuire, M.J.; Lipsky, P.E.; Thiele, D.L.
Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I
J. Biol. Chem.
268
2458-2567
1993
Homo sapiens, Mus musculus
brenda
Murakami, M.; Karnik, S.S.; Husain, A.
Human prochymase activation. A novel role for heparin in zymogen processing
J. Biol. Chem.
270
2218-2223
1995
Homo sapiens
brenda
Jans, R.; Sartor, M.; Jadot, M.; Poumay, Y.
Calcium entry into keratinocytes induces exocytosis of lysosomes
Arch. Dermatol. Res.
296
30-41
2004
Homo sapiens
brenda
Bondebjerg, J.; Fuglsang, H.; Valeur, K.R.; Kaznelson, D.W.; Hansen, J.A.; Pedersen, R.O.; Krogh, B.O.; Jensen, B.S.; Lauritzen, C.; Petersen, G.; Pedersen, J.; Naerum, L.
Novel semicarbazide-derived inhibitors of human dipeptidyl peptidase I (hDPPI)
Bioorg. Med. Chem.
13
4408-4424
2005
Homo sapiens
brenda
Meade, J.L.; de Wynter, E.A.; Brett, P.; Sharif, S.M.; Woods, C.G.; Markham, A.F.; Cook, G.P.
A family with Papillon-Lefevre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity
Blood
107
3665-3668
2006
Homo sapiens
brenda
Berdowska, I.
Cysteine proteases as disease markers
Clin. Chim. Acta
342
41-69
2004
Homo sapiens
brenda
Vojdani, A.; Bazargan, M.; Vojdani, E.; Samadi, J.; Nourian, A.A.; Eghbalieh, N.; Cooper, E.L.
Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease
Clin. Diagn. Lab. Immunol.
11
515-524
2004
Homo sapiens
brenda
de Haar, S.F.; Tigchelaar-Gutter, W.; Everts, V.; Beertsen, W.
Structure of the periodontium in cathepsin C-deficient mice
Eur. J. Oral Sci.
114
171-173
2006
Homo sapiens
brenda
Hewitt, C.; McCormick, D.; Linden, G.; Turk, D.; Stern, I.; Wallace, I.; Southern, L.; Zhang, L.; Howard, R.; Bullon, P.; Wong, M.; Widmer, R.; Gaffar, K.A.; Awawdeh, L.; Briggs, J.; Yaghmai, R.; Jabs, E.W.; Hoeger, P.; Bleck, O.; Ruediger, S.G.; Petersilka, G.; Battino, M.; Brett, P.; Hattab, F.; Al-Hamed, M.; Sloan, P.; Toomes, C.; Dixon, M.; James, J.; Read, A.P.; Thakker, N.
The role of cathepsin C in Papillon-Lefevre syndrome, prepubertal periodontitis, and aggressive periodontitis
Hum. Mutat.
23
222-228
2004
Homo sapiens
brenda
Ishri, R.K.; Menzies, S.; Hersey, P.; Halliday, G.M.
Rapid downregulation of antigen processing enzymes in ex vivo generated human monocyte derived dendritic cells occur endogenously in extended cultures
Immunol. Cell Biol.
82
239-246
2004
Homo sapiens
brenda
Pham, C.T.; Ivanovich, J.L.; Raptis, S.Z.; Zehnbauer, B.; Ley, T.J.
Papillon-Lefevre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans
J. Immunol.
173
7277-7281
2004
Homo sapiens (P53634), Homo sapiens
brenda
Lautwein, A.; Kraus, M.; Reich, M.; Burster, T.; Brandenburg, J.; Overkleeft, H.S.; Schwarz, G.; Kammer, W.; Weber, E.; Kalbacher, H.; Nordheim, A.; Driessen, C.
Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner
J. Leukocyte Biol.
75
844-855
2004
Homo sapiens
brenda
Hsiung, H.M.; Smiley, D.L.; Zhang, X.y.; Zhang, L.; Yan, L.Z.; Craft, L.; heiman, M.L.; Smith, D.P.
Potent peptide agonists for human melanocortin 3 and 4 receptors derived from enzymatic cleavages of human beta-MSH(5-22) by dipeptidyl peptidase I and dipeptidyl peptidase IV
Peptides
26
1988-1996
2005
Homo sapiens
brenda
Dabrowska, E.; Letko, M.; Roszkowska-Jakimiec, W.; Letko, R.; Jamiolkowski, J.
Effect of fluoride preparations on the activity of human salivary cathepsin C
Rocz. Akad. Med. Bialymst.
50
160-162
2005
Homo sapiens
-
brenda
Altorjay, A.; Paal, B.; Sohar, N.; Kiss, J.; Szanto, I.; Sohar, I.
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus
World J. Gastroenterol.
11
5751-5756
2005
Homo sapiens
brenda
Schneck, J.L.; Villa, J.P.; McDevitt, P.; McQueney, M.S.; Thrall, S.H.; Meek, T.D.
Chemical mechanism of a cysteine protease, cathepsin C, as revealed by integration of both steady-state and pre-steady-state solvent kinetic isotope effects
Biochemistry
47
8697-8710
2008
Homo sapiens
brenda
Noack, B.; Goergens, H.; Hempel, U.; Fanghaenel, J.; Hoffmann, T.; Ziegler, A.; Schackert, H.K.
Cathepsin C gene variants in aggressive periodontitis
J. Dent. Res.
87
958-963
2008
Homo sapiens
brenda
Latajka, R.; Jewginski, M.; Makowski, M.; Pawe?czak, M.; Huber, T.; Sewald, N.; Kafarski, P.
Pentapeptides containing two dehydrophenylalanine residues-synthesis, structural studies and evaluation of their activity towards cathepsin C
J. Pept. Sci.
14
1084-1095
2008
Homo sapiens
brenda
Guay, D.; Beaulieu, C.; Truchon, J.F.; Jagadeeswar Reddy, T.; Zamboni, R.; Bayly, C.I.; Methot, N.; Rubin, J.; Ethier, D.; David Percival, M.
Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C
Bioorg. Med. Chem. Lett.
19
5392-5396
2009
Homo sapiens
brenda
Li, J.; Petrassi, H.; Tumanut, C.; Masick, B.; Trussell, C.; Harris, J.
Substrate optimization for monitoring cathepsin C activity in live cells
Bioorg. Med. Chem.
17
1064-1070
2009
Homo sapiens
brenda
Kurban, M.; Wajid, M.; Shimomura, Y.; Bahhady, R.; Kibbi, A.G.; Christiano, A.M.
Evidence for a founder mutation in the cathepsin C gene in three families with Papillon-Lefevre syndrome
Dermatology
219
289-294
2009
Homo sapiens
brenda
Legowska, M.; Hamon, Y.; Wojtysiak, A.; Grzywa, R.; Sie?czyk, M.; Burster, T.; Korkmaz, B.; Lesner, A.
Development of the first internally-quenched fluorescent substrates of human cathepsin C The application in the enzyme detection in biological samples
Arch. Biochem. Biophys.
612
91-102
2016
Homo sapiens (P53634), Homo sapiens
brenda
Hamon, Y.; Legowska, M.; Fergelot, P.; Dallet-Choisy, S.; Newell, L.; Vanderlynden, L.; Kord Valeshabad, A.; Acrich, K.; Kord, H.; Charalampos, T.; Morice-Picard, F.; Surplice, I.; Zoidakis, J.; David, K.; Vlahou, A.; Ragunatha, S.; Nagy, N.; Farkas, K.; Szell, M.; Goizet, C.; Schacher, B.; Battino, M.
Analysis of urinary cathepsin C for diagnosing Papillon-Lefevre syndrome
FEBS J.
283
498-509
2016
Homo sapiens (P53634), Homo sapiens
brenda
Hamon, Y.; Legowska, M.; Herve, V.; Dallet-Choisy, S.; Marchand-Adam, S.; Vanderlynden, L.; Demonte, M.; Williams, R.; Scott, C.J.; Si-Tahar, M.; Heuze-Vourch, N.; Lalmanach, G.; Jenne, D.E.; Lesner, A.; Gauthier, F.; Korkmaz, B.
Neutrophilic cathepsin C is maturated by a multistep proteolytic process and secreted by activated cells during inflammatory lung diseases
J. Biol. Chem.
291
8486-8499
2016
Homo sapiens (P53634), Homo sapiens
brenda
Rebernik, M.; Lenarcic, B.; Novinec, M.
The catalytic domain of cathepsin C (dipeptidyl-peptidase I) alone is a fully functional endoprotease
Protein Expr. Purif.
157
21-27
2019
Homo sapiens (P53634)
brenda