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Arg-4-methylcoumaryl-7-amide + H2O
Arg + 7-amino-4-methylcoumarin
-
-
?
Arg 4-methylcoumarin 7-amide + H2O
Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Arg-4-methylcoumarin 7-amide + H2O
Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Arg-7-amido-4-methylcoumarin + H2O
Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Arg-Lys-Asp-Val-Tyr-OH + H2O
?
-
-
-
-
?
Arg-Met-enkephalin + H2O
?
-
-
-
-
?
kallidin + H2O
?
-
-
-
-
?
kallidin + H2O
bradykinin + ?
i.e. KRPPGFSPFR
-
-
?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
-
-
-
-
?
L-Arg-7-amido-4-methylcoumarin + H2O
L-Arg + 7-amino-4-methylcoumarin
100% activity
-
-
?
L-Arg-p-nitroanilide + H2O
L-Arg + p-nitroaniline
-
-
-
-
?
L-Gln-7-amido-4-methylcoumarin + H2O
L-Gln + 7-amino-4-methylcoumarin
about 1% activity compared to L-Arg-7-amido-4-methylcoumarin
-
-
?
L-Ile-7-amido-4-methylcoumarin + H2O
L-Ile + 7-amino-4-methylcoumarin
about 1% activity compared to L-Arg-7-amido-4-methylcoumarin
-
-
?
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
about 1% activity compared to L-Arg-7-amido-4-methylcoumarin
-
-
?
L-Lys-7-amido-4-methylcoumarin + H2O
L-Lys + 7-amino-4-methylcoumarin
about 45% activity compared to L-Arg-7-amido-4-methylcoumarin
-
-
?
L-Met-7-amido-4-methylcoumarin + H2O
L-Met + 7-amino-4-methylcoumarin
about 1% activity compared to L-Arg-7-amido-4-methylcoumarin
-
-
?
L-Phe-7-amido-4-methylcoumarin + H2O
L-Phe + 7-amino-4-methylcoumarin
about 5% activity compared to L-Arg-7-amido-4-methylcoumarin
-
-
?
L-Tyr-7-amido-4-methylcoumarin + H2O
L-Tyr + 7-amino-4-methylcoumarin
about 7% activity compared to L-Arg-7-amido-4-methylcoumarin
-
-
?
L-Val-7-amido-4-methylcoumarin + H2O
L-Val + 7-amino-4-methylcoumarin
about 1% activity compared to L-Arg-7-amido-4-methylcoumarin
-
-
?
Lys 4-methylcoumarin 7-amide + H2O
Lys + 7-amino-4-methylcoumarin
-
-
-
-
?
Lys-2-naphthylamide + H2O
Lys + 2-naphthylamine
-
-
-
-
?
Lys-4-methylcoumarin 7-amide + H2O
Lys + 7-amino-4-methylcoumarin
-
-
-
-
?
Met-enkephalin + H2O
?
-
-
-
-
?
[Arg0]-Met-enkephalin + H2O
Met-enkephalin + de-[Tyr]-Met-enkephalin
i.e. RYGGFM
-
-
?
additional information
?
-
Arg-peptides + H2O
?
-
-
-
-
?
Arg-peptides + H2O
?
-
or Lys-peptides, metabolism of kinin
-
-
?
Arg-peptides + H2O
?
-
attribution to inflammatory and wound healing processes
-
-
?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
about 2% activity compared to L-Arg-7-amido-4-methylcoumarin
-
-
?
additional information
?
-
the enzyme is induced by interferon-gamma, the enzyme can trim the N-terminal extended precursor to antigenic peptides in the endoplasmic reticulum
-
?
additional information
?
-
-
the enzyme is induced by interferon-gamma, the enzyme can trim the N-terminal extended precursor to antigenic peptides in the endoplasmic reticulum
-
?
additional information
?
-
-
the enzyme probably is involved in the final stages of peptide and protein precursor processing and maturation mechanisms via the exopeptidase pathway and thereby in some inflammatory processes and tumour development
-
-
?
additional information
?
-
-
the enzyme from testis preferably removes Arg and/or Lys residues from the N-terminus of various peptides, no activity with substrate possessing Pro at the P1 position
-
-
?
additional information
?
-
-
the enzyme is strictly specific for the removal of N-terminal basic residues from peptides and proteins
-
-
?
additional information
?
-
no activity with L-Cys-7-amido-4-methylcoumarin, L-Asp-7-amido-4-methylcoumarin, and L-Glu-7-amido-4-methylcoumarin
-
-
?
additional information
?
-
-
no activity with L-Cys-7-amido-4-methylcoumarin, L-Asp-7-amido-4-methylcoumarin, and L-Glu-7-amido-4-methylcoumarin
-
-
?
additional information
?
-
the aminopeptidase binding site shares a similar structure to LTA4H (EC 3.3.2.6) at its ligand binding sites
-
-
?
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1,10-phenanthroline
effective
(S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)-4-methylpentanoic acid
-
1-methyl cyclohexan bestatin
-
i.e. BE15, strong inhibition
3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]-propanoic acid
-
4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
enzyme binding structure, overview
5,5'-dithiobis(2-nitrobenzoate)
-
-
DX600
-
only blocks human ACE2 activity but not mouse
kallidin
-
human peptide hormone, 10 microM, Arg 4-methylcoumarin 7-amide hydrolysis: 73.7% (wild-type enzyme)
MLN-4760
-
MLN-4760 inhibits both human and mouse ACE2
N-(6-(2-aminophenylamino)-6-oxyhexyl)-4-methylbenzamide
-
p-chloromercuribenzoate
-
-
p-Hydroxymercuriphenylsulfonic acid
-
-
suberanilohydroxamic acid
enzyme binding structure, overview
-
tert-butyl bestatin
-
i.e. BE17, the BE15 derivative has a dual inhibitory effect of invasion and motility on tumor and endothelial cells
[(2Z)-3-[(7-chloro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)methyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
11.7% inhibition at 0.01 mM
[(2Z)-3-[2-(6-methyl-4-oxo-1,2,3-benzotriazin-3(4H)-yl)ethyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
54.8% inhibition at 0.01 mM
[(2Z)-3-[2-(6-nitro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)ethyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
32.8% inhibition at 0.01 mM
[(2Z)-3-[2-(7-bromo-4-oxo-1,2,3-benzotriazin-3(4H)-yl)ethyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
53.5% inhibition at 0.01 mM
[(2Z)-3-[2-(7-chloro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)ethyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
65.2% inhibition at 0.01 mM
[(2Z)-3-[2-(7-fluoro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)ethyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
36.4% inhibition at 0.01 mM
[(2Z)-3-[4-(6-methyl-4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
26.0% inhibition at 0.01 mM
[(2Z)-3-[4-(6-nitro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
22.2% inhibition at 0.01 mM
[(2Z)-3-[4-(7-bromo-4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
26.8% inhibition at 0.01 mM
[(2Z)-3-[4-(7-chloro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
33.7% inhibition at 0.01 mM
[(2Z)-3-[4-(7-fluoro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
26.0% inhibition at 0.01 mM
[(2Z)-3-[5-(6-methyl-4-oxo-1,2,3-benzotriazin-3(4H)-yl)pentyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
52.6% inhibition at 0.01 mM
[(2Z)-3-[5-(6-nitro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)pentyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
34.1% inhibition at 0.01 mM
[(2Z)-3-[5-(7-bromo-4-oxo-1,2,3-benzotriazin-3(4H)-yl)pentyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
78.8% inhibition at 0.01 mM
[(2Z)-3-[5-(7-chloro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)pentyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
76.1% inhibition at 0.01 mM
[(2Z)-3-[5-(7-fluoro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)pentyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
54.0% inhibition at 0.01 mM
[(2Z)-3-[6-(5-chloro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)hexyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
37.8% inhibition at 0.01 mM
[(2Z)-3-[6-(6-chloro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)hexyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
68.8% inhibition at 0.01 mM
[(2Z)-3-[6-(6-methyl-4-oxo-1,2,3-benzotriazin-3(4H)-yl)hexyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
62.5% inhibition at 0.01 mM
[(2Z)-3-[6-(6-nitro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)hexyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
36.9% inhibition at 0.01 mM
[(2Z)-3-[6-(7-bromo-4-oxo-1,2,3-benzotriazin-3(4H)-yl)hexyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
70.6% inhibition at 0.01 mM
[(2Z)-3-[6-(7-chloro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)hexyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
80.6% inhibition at 0.01 mM
[(2Z)-3-[6-(7-fluoro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)hexyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
51.7% inhibition at 0.01 mM
[(2Z)-3-[6-(7-methoxy-4-oxo-1,2,3-benzotriazin-3(4H)-yl)hexyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
50.3% inhibition at 0.01 mM
[(2Z)-3-[6-(7-nitro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)hexyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
34.6% inhibition at 0.01 mM
[(2Z)-3-[6-(8-chloro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)hexyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
37.9% inhibition at 0.01 mM
[(2Z)-4-oxo-3-[(4-oxo-1,2,3-benzotriazin-3(4H)-yl)methyl]-1,3-thiazolidin-2-ylidene]cyanamide
over 10.0% inhibition at 0.01 mM
[(2Z)-4-oxo-3-[2-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)ethyl]-1,3-thiazolidin-2-ylidene]cyanamide
30.2% inhibition at 0.01 mM
[(2Z)-4-oxo-3-[2-[4-oxo-6-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]ethyl]-1,3-thiazolidin-2-ylidene]cyanamide
55.6% inhibition at 0.01 mM
[(2Z)-4-oxo-3-[4-[4-oxo-6-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butyl]-1,3-thiazolidin-2-ylidene]cyanamide
41.6% inhibition at 0.01 mM
[(2Z)-4-oxo-3-[5-[4-oxo-6-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]pentyl]-1,3-thiazolidin-2-ylidene]cyanamide
50.1% inhibition at 0.01 mM
[(2Z)-4-oxo-3-[6-[4-oxo-6-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]hexyl]-1,3-thiazolidin-2-ylidene]cyanamide
60.1% inhibition at 0.01 mM
[(2Z)-4-oxo-3-[[4-oxo-6-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]methyl]-1,3-thiazolidin-2-ylidene]cyanamide
15.8% inhibition at 0.01 mM
1,10-phenanthroline
-
-
1,10-phenanthroline
-
activity restored by Co2+
arphamenine A
-
-
Arphamenine B
-
-
bestatin
-
-
Substance P
-
human peptide hormone, 10 microM, Arg 4-methylcoumarin 7-amide hydrolysis: 78% (wild-type enzyme)
Substance P
-
human peptide hormone, 100 microM, Arg 4-methylcoumarin 7-amide hydrolysis: 63.8% (wild-type enzyme)
additional information
EDTA has no effect up to 1 mM
-
additional information
-
EDTA has no effect up to 1 mM
-
additional information
-
inhibitory potency of bestatin and derivatives on enzyme activity, umbilical vein endothelial cell vessel formation, and cell invasion and migration, overview
-
additional information
drug repurposing of histone deacetylase (HDAC) inhibitors that alleviate neutrophilic inflammation in acute lung injury and idiopathic pulmonary fibrosis via inhibiting leukotriene A4 hydrolase and blocking LTB4 biosynthesis, overview. Analysis of potential inhibitors of LTA4H across a panel of 18 HDAC inhibitors, using enzymatic assay, thermofluor assay, and X-ray crystallographic investigation. Detailed mechanisms of down-regulation of proinflammatory cytokines by SAHA or M344 are determined in vivo. Cotreatment of N-(6-(2-aminophenylamino)-6-oxyhexyl)-4-methylbenzamide and (S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)-4-methylpentanoic acid synergistically represses the migration of neutrophil and LTB4-induced neutrophil migration is not affected by these treatments. Molecular modeling of HDAC inhibitors against LTA4H hydrolase and aminopeptidase
-
additional information
synthesis and evaluation of a series of 1,2,3-benzotriazin-4-one derivatives as inhibitors of leukotriene A4 hydrolase aminopeptidase activity of the enzyme in vitro, overview. Molecular docking and structure-activity relationship of the inhibitors, IC50 values for cytotoxic effects on THP-1 cells
-
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Acquired Immunodeficiency Syndrome
Perceptions of vulnerability: impact on AIDS-preventive behavior among college adolescents.
Adenocarcinoma
Placental type of membrane-bound arylamidase (Shiba isoenzyme) found in human cancerous lung.
Adenoma
Altered Activity and Expression of Cytosolic Peptidases in Colorectal Cancer.
Alzheimer Disease
Changes of renin-angiotensin system-related aminopeptidases in early stage Alzheimer's disease.
Alzheimer Disease
Obese mice exposed to psychosocial stress display cardiac and hippocampal dysfunction associated with local brain-derived neurotrophic factor depletion.
Amyotrophic Lateral Sclerosis
Prolonged distal latency of the median motor nerve is associated with poor prognosis in amyotrophic lateral sclerosis.
Aneurysm
Loss of Contralateral Upper Limb Motor Evoked Potential Due to Occlusion of the Internal Carotid Artery in Microsurgical Clipping of Basilar Tip Aneurysm.
Angina Pectoris
Conduction Delay-Induced J-Wave Augmentation in Patients With Coronary Heart Disease.
Arrhythmias, Cardiac
Combining neural networks and ANFIS classifiers for supervised examining of electrocardiogram beats.
Asthma
Studies of immunologic and inflammatory factors in saliva in patients with asthma and in patients with periodontitis.
Astrocytoma
A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas.
Astrocytoma
Differential Effects of Doxazosin on Renin-Angiotensin-System-Regulating Aminopeptidase Activities in Neuroblastoma and Glioma Tumoral Cells.
Atherosclerosis
The association between peptidoglycan recognition protein-1 and coronary and peripheral atherosclerosis: Observations from the Dallas Heart Study.
Bacterial Infections
Complete Genome Sequence of Streptomyces olivoreticuli ATCC 31159 Which can Produce Anticancer Bestatin and Show Diverse Secondary Metabolic Potentials.
Biliary Tract Diseases
[Diagnostic significance of amino acid arylamidase (alanine aminopeptidase) and its isoenzymes 1 and 2 in pancreatic and biliary tract diseases]
Blister
Acid hydrolases in blister fluid. 3. Characterization and quantification of peptide hydrolases.
Brain Neoplasms
Faecal proteome in clinically healthy dogs and cats: Findings in pooled faeces from 10 cats and 10 dogs.
Breast Neoplasms
Impact of dose engine algorithm in pencil beam scanning proton therapy for breast cancer.
Breast Neoplasms
Neoadjuvant chemotherapy modifies serum angiotensinase activities in women with breast cancer.
Breast Neoplasms
Renin angiotensin system-regulating aminopeptidase activities in serum of pre- and postmenopausal women with breast cancer.
Breast Neoplasms
Renin-Angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea.
Breast Neoplasms
Use of a tumor-cell enrichment column for the enhanced detection of minimal residual disease in the BM or apheresis peripheral blood transplant products of breast-cancer patients.
Bulbo-Spinal Atrophy, X-Linked
Prolonged distal latency of the median motor nerve is associated with poor prognosis in amyotrophic lateral sclerosis.
Candidiasis
Enhanced enzymatic activity of Candida species responsible for oral candidiasis in renal transplant recipients.
Carcinoma
A placental type of membrane-bound arylamidase in serum and ascites from a patient with renal cell carcinoma.
Carcinoma
Altered Activity and Expression of Cytosolic Peptidases in Colorectal Cancer.
Carcinoma
OF4949, new inhibitors of aminopeptidase B. IV. Effects of OF4949 and its derivatives on enzyme systems.
Carcinoma
Placental form of membrane-bound neutral arylamidase found in renal cell carcinoma.
Carcinoma
[A placental type of membrane-bound arylamidase found in patients with renal cell carcinoma (author's transl)]
Carcinoma, Hepatocellular
Arylamidases of rat liver and chemically induced hepatomas. 1. Subcellular distribution of L-leucine. 2. Naphthylamidase-active antigens.
Carcinoma, Hepatocellular
Membrane-bound arylamidase from human hepatoma cells having the same electrophoretic mobility as placental membrane-bound arylamidase.
Carcinoma, Hepatocellular
[A patient with hepatoma in which tissue placental form of membrane-bound arylamidase was found - report of an autopsy case (author's transl)]
Carcinoma, Renal Cell
A placental type of membrane-bound arylamidase in serum and ascites from a patient with renal cell carcinoma.
Carcinoma, Renal Cell
Placental form of membrane-bound neutral arylamidase found in renal cell carcinoma.
Carcinoma, Renal Cell
[A placental type of membrane-bound arylamidase found in patients with renal cell carcinoma (author's transl)]
Cardiac Complexes, Premature
Heart rate turbulence after atrial and ventricular premature beats: relation to left ventricular function and coupling intervals.
Carpal Tunnel Syndrome
First lumbrical latency and amplitude. Control values and findings in carpal tunnel syndrome.
Carpal Tunnel Syndrome
Prolonged distal latency of the median motor nerve is associated with poor prognosis in amyotrophic lateral sclerosis.
Carpal Tunnel Syndrome
The relationship between preoperative needle electromyography findings and muscle power restoration after surgery in severe carpal tunnel syndrome patients.
Carpal Tunnel Syndrome
Thumb opposition in severe carpal tunnel syndrome with undetectable APB-CMAP.
Carpal Tunnel Syndrome
Transfer of the flexor carpi radialis to the abductor pollicis brevis tendon for the restoration of tip-pinch in severe carpal tunnel syndrome.
Chemical and Drug Induced Liver Injury
Drug-induced liver injury and microsomal arylamidase activity in needle biopsy of human liver.
Colorectal Neoplasms
Targeting normal and neoplastic tissues in the rat jejunum and colon with boronated, cationic acrylamide copolymers.
Diabetic Neuropathies
[Comparison of nerve conduction studies between conventional and lumbrical/interossei recording methods in diabetics]
Endocarditis
Very long-term outcomes of twisted auto-pericardial mitral annuloplasty.
Essential Hypertension
Circulating Aminopeptidase Activities in Men and Women with Essential Hypertension.
Fasciculation
Cortical hyperexcitability precedes lower motor neuron dysfunction in ALS.
Fibrosarcoma
Inhibition of tumor cell invasion and matrix degradation by aminopeptidase inhibitors.
Glioma
Anti-Inflammatory and Antitumor Effects of Hydroxytyrosol but Not Oleuropein on Experimental Glioma In Vivo. A Putative Role for the Renin-Angiotensin System.
Glomerulonephritis
[Serum and urinary gamma-glutamyl transpeptidase and leucine arylamidase activity in various forms of chronic glomerulonephritis]
Heart Diseases
Progression of paroxysmal atrial fibrillation to persistent atrial fibrillation in patients with bradyarrhythmias.
Hepatitis
[Suitability of "classical" leucine aminopeptidase (LAP) as indicator enzyme in hepatitis epidemica acuta. Differentiation between leucine aminopeptidase and arylamidase in hepatobiliary illnesses]
Histiocytoma
Immunological characterization of an arylamidase (aminopeptidase) occurring in histiocytoma.
Hyperesthesia
[Carpal tunnel syndrome. Results of electrodiagnostic studies.]
Hyperopia
ERG of form deprivation myopia and drug induced ametropia in chicks.
Hypersensitivity
Enhancement of delayed-type hypersensitivity by bestatin, an inhibitor of aminopeptidase B and leucine aminopeptidase.
Hypersensitivity
Small molecular microbial products enhancing immune response.
Hypersensitivity, Delayed
Increased sensitivity of IL2-dependent cultured T cells and enhancement of in vitro IL2 production by human lymphocytes treated with Bestatin.
Hypersensitivity, Delayed
New microbial secondary metabolites under preclinical development for cancer treatment.
Hypertension
Activities of aminopeptidases in a rat saline model of volume hypertension.
Hypertension
Evaluation of urinary enzyme patterns in patients with kidney diseases and primary benign hypertension.
Hypertension
Inhibitors of aminopeptidase B suppress the development of hypertension in spontaneously hypertensive rats.
Hypertension
Renal aminopeptidase activities in animal models of hypertension.
Hypertension, Renovascular
Renal aminopeptidase activities in animal models of hypertension.
Hypesthesia
Management of extreme carpal tunnel syndrome: Evidence from a long-term follow-up study.
Illusions
Perceptions of vulnerability: impact on AIDS-preventive behavior among college adolescents.
Immune Reconstitution Inflammatory Syndrome
Secondary MGUS following by adenovirus-induced hemorrhagic cystitis after autologous peripheral blood stem cell transplantation in a patient with multiple myeloma.
Infections
A comparison of ex vivo expanded DCs derived from cord blood and mobilized adult peripheral blood plastic-adherent mononuclear cells: decreased alloreactivity of cord blood DCs.
Infections
Effect of influenza A infection on maturation and function of neonatal monocyte-derived dendritic cells.
Infections
Increased cytosol aminopeptidase and lactate dehydrogenase in serum originating from lymphocytes in measles and rubella infection.
Infections
Increased cytosol aminopeptidase in serum in measles infection.
Influenza, Human
Effect of influenza A infection on maturation and function of neonatal monocyte-derived dendritic cells.
Kidney Neoplasms
Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma.
Kidney Neoplasms
Arylamidase from human renal cancer tissue in comparison with normal kidney and placental enzymes.
Leukemia
Localization of hRad9, hHus1, hRad1, and hRad17 and caffeine-sensitive DNA replication at the alternative lengthening of telomeres-associated promyelocytic leukemia body.
Leukemia
The Analgesic Activity of Bestatin as a Potent APN Inhibitor.
Liposarcoma
ALT-associated promyelocytic leukaemia body (APB) detection as a reproducible tool to assess alternative lengthening of telomere stability in liposarcomas.
Liver Diseases
[Ornithine carbamyl transferase, 5'nucleotidase and leucine arylamidase as diagnostic parameters in liver diseases of dogs]
Liver Diseases
[Serum arylamidase isoenzymes in pancreatic and liver diseases]
Liver Neoplasms
Aminopeptidases and arylamidases in normal and cancer tissues in humans.
Lung Neoplasms
Aminopeptidases and arylamidases in normal and cancer tissues in humans.
Lung Neoplasms
Validation of the RayStation Monte Carlo dose calculation algorithm using a realistic lung phantom.
Lymphadenitis
Increased activities of cytosol aminopeptidase and lactate dehydrogenase in serum originate from lymphocytes in necrotizing lymphadenitis.
Lymphocytosis
Cell-mediated immunity in pigeon breeders' lung: the effect of removal from antigen exposure.
Measles
Increased cytosol aminopeptidase and lactate dehydrogenase in serum originating from lymphocytes in measles and rubella infection.
Measles
Increased cytosol aminopeptidase in serum in measles infection.
Melanoma
Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice.
Muscular Atrophy
Dissociated small hand muscle atrophy in amyotrophic lateral sclerosis: Frequency, extent, and specificity.
Muscular Atrophy
Prolonged distal latency of the median motor nerve is associated with poor prognosis in amyotrophic lateral sclerosis.
Muscular Atrophy
Thumb opposition in severe carpal tunnel syndrome with undetectable APB-CMAP.
Muscular Atrophy, Spinal
Prolonged distal latency of the median motor nerve is associated with poor prognosis in amyotrophic lateral sclerosis.
Muscular Dystrophies
Arylamidase and cathepsin-A activity of normal and dystrophic human muscle.
Muscular Dystrophies
Arylamidases in normal and diseased human muscle.
Mycoses
The hydrolytic enzymes produced by fungi strains isolated from the sand and soil of recreational areas
Myocardial Infarction
Conduction Delay-Induced J-Wave Augmentation in Patients With Coronary Heart Disease.
Myocardial Ischemia
QT-interval turbulence induced by atrial and ventricular extrastimuli in patients with ventricular tachycardia.
Myopia
ERG of form deprivation myopia and drug induced ametropia in chicks.
Neoplasm Metastasis
Transport mechanisms of bestatin in rabbit intestinal brush-border membranes: role of H+/dipeptide cotransport system.
Neoplasm, Residual
Use of a tumor-cell enrichment column for the enhanced detection of minimal residual disease in the BM or apheresis peripheral blood transplant products of breast-cancer patients.
Neoplasms
A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas.
Neoplasms
Acrokeratosis paraneoplastica Bazex syndrome associated with esophageal squamocellular carcinoma.
Neoplasms
Altered Activity and Expression of Cytosolic Peptidases in Colorectal Cancer.
Neoplasms
Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma.
Neoplasms
Aminopeptidase activities on the surface of mammalian cells and their alterations associated with transformation.
Neoplasms
Aminopeptidases and angiotensin I-converting enzyme activities in primary human lung tumors and lung parenchyma.
Neoplasms
An "extra" arylamidase isoenzyme band in the serum of a cancer patient.
Neoplasms
Changes in cell-surface peptidase activity in papillary renal cell carcinoma.
Neoplasms
Complete Genome Sequence of Streptomyces olivoreticuli ATCC 31159 Which can Produce Anticancer Bestatin and Show Diverse Secondary Metabolic Potentials.
Neoplasms
Epigenetic promoter alterations in GI tumour immune-editing and resistance to immune checkpoint inhibition.
Neoplasms
Increase of the stimulatory effect of dendritic cells by pulsing with apoptotic bodies transfected with the MHC class II gene.
Neoplasms
Increased sensitivity of IL2-dependent cultured T cells and enhancement of in vitro IL2 production by human lymphocytes treated with Bestatin.
Neoplasms
Insulin-regulated aminopeptidase/placental leucil Aminopeptidase (IRAP/P-lAP) and angiotensin IV-forming activities are modified in serum of rats with breast cancer induced by N-methyl-nitrosourea.
Neoplasms
Regulation of CD28 expression on umbilical cord blood and adult peripheral blood CD8(+) T cells by interleukin(IL)-15/IL-21.
Neoplasms
Small molecular microbial products enhancing immune response.
Neoplasms
The Analgesic Activity of Bestatin as a Potent APN Inhibitor.
Neoplasms
The variability of motor evoked potential latencies in neurosurgical motor mapping by preoperative navigated transcranial magnetic stimulation.
Neoplasms
Transport mechanisms of bestatin in rabbit intestinal brush-border membranes: role of H+/dipeptide cotransport system.
Neoplasms
Tumor apoptotic bodies inhibit CTL responses and antitumor immunity via membrane-bound transforming growth factor-beta1 inducing CD8+ T-cell anergy and CD4+ Tr1 cell responses.
Neoplasms
Use of a tumor-cell enrichment column for the enhanced detection of minimal residual disease in the BM or apheresis peripheral blood transplant products of breast-cancer patients.
Neoplasms
[Dynamics of the changes in cytosol aminopeptidase, aminopeptidase I (microsomal) and gamma-glutamyltransferase activities during brachytherapy of cancer of the uterine cervix and corpus]
Nephrotic Syndrome
[Urinary neutral arylamidase in nephrotic syndrome among children]
Neuroblastoma
Differential Effects of Doxazosin on Renin-Angiotensin-System-Regulating Aminopeptidase Activities in Neuroblastoma and Glioma Tumoral Cells.
Neuroblastoma
Expression and retinoid modulation of N-arginine dibasic convertase and an aminopeptidase-B in human neuroblastoma cell lines.
Neurofibrosarcoma
Telomere maintenance mechanisms in malignant peripheral nerve sheath tumors: expression and prognostic relevance.
Neuromuscular Diseases
Arylamidase and cathepsin-A activity of normal and dystrophic human muscle.
Osteoarthritis
Long-term follow-up of basal joint resection arthroplasty of the thumb with transfer of the abductor pollicis brevis origin to the flexor carpi radialis tendon.
Osteosarcoma
A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas.
Ovarian Neoplasms
[Cisplatin and ovarian carcinoma--early detection of cisplatin-induced nephrotoxicity]
Overweight
The Relationship Between C-Reactive Protein and Atherosclerosis Differs on the Basis of Body Mass Index: The Dallas Heart Study.
Pancreatic Diseases
[Isoenzymes of the amino acid arylamidase (ANAse) and its significance for the diagnosis of pancreatic diseases]
Pancreatic Neoplasms
[Isoenzymes of alanine arylamidase (AAP, EC 3.4.11.2) and gamma-glutamyltranspeptidase (GGTP, EC 2.3.2.2) in chronic pancreatitis and pancreas neoplasm (author's transl)]
Pancreatitis
Transgenic expression of GFP-LC3 perturbs autophagy in exocrine pancreas and acute pancreatitis responses in mice.
Pancreatitis, Chronic
[Isoenzymes of alanine arylamidase (AAP, EC 3.4.11.2) and gamma-glutamyltranspeptidase (GGTP, EC 2.3.2.2) in chronic pancreatitis and pancreas neoplasm (author's transl)]
Paralysis
Design, Synthesis and PASS Assisted Evaluation of Novel 2-Substituted Benzimidazole Derivatives as Potent Anthelimintics.
Paralysis
Quantitative ultrasound imaging of intrinsic hand muscles after traumatic cervical spinal cord injury.
Paralysis
The effects of low median nerve block on thumb abduction strength.
Paralysis
Transfer of the flexor carpi radialis to the abductor pollicis brevis tendon for the restoration of tip-pinch in severe carpal tunnel syndrome.
Paresis
Characteristics of F-wave in different stretched positions of the affected arm in patients with cerebrovascular diseases.
Paresthesia
Management of extreme carpal tunnel syndrome: Evidence from a long-term follow-up study.
Periodontitis
Studies of immunologic and inflammatory factors in saliva in patients with asthma and in patients with periodontitis.
Pheochromocytoma
Aminopeptidase B: a processing enzyme secreted and associated with the plasma membrane of rat pheochromocytoma (PC12) cells.
Pregnancy, Prolonged
[Arylamidase and gamma-glutamyltranspeptidase activity in serum and urine of women with prolonged pregnancy]
Psoriasis
Incomplete arylamidase in psoriasis scales.
Quadriplegia
Restoration of active palmar abduction of the thumb in tetraplegia by tendon transfer of the extensor digiti minimi to abductor pollicis brevis.
Rubella
Increased cytosol aminopeptidase and lactate dehydrogenase in serum originating from lymphocytes in measles and rubella infection.
Sarcoma
A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas.
Sepsis
Evaluating the effect of infliximab on the healing of left colonic anastomosis in the presence of intra-abdominal sepsis.
Sepsis
Lysosomal enzyme pattern in lung lymph and blood during E. coli sepsis in sheep.
Shoulder Pain
Can APB 2000 Be Used to Discern Sincerity of Effort in Unimpaired Subjects from Maximal Performance in Subjects with Shoulder Pain?
Starvation
Metabolic and compositional changes in Escherichia coli cells starved in seawater.
Stomach Neoplasms
Aminopeptidases and arylamidases in normal and cancer tissues in humans.
Stroke
Guided motor imagery in healthy adults and stroke: does strategy matter?
Stroke
Side of lesion influences interhemispheric inhibition in subjects with post-stroke hemiparesis.
Stroke
Startle responses after different stimulus modalities differ in stroke.
Tachycardia
Pacing techniques in the prophylaxis of junctional reentry tachycardia.
Thyroid Cancer, Papillary
A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas.
Tinea
Efficacy of 6-amino-2-n-pentylthiobenzothiazole on Trichophyton in vitro and in vivo.
Tonsillitis
Activity of soluble aminopeptidase A and dipeptidyl peptidase IV and membrane-bound aminopeptidase B and pyroglutamyl peptidase I in adenoid hyperplasia, tonsillar hyperplasia and chronic tonsillitis.
Urinary Bladder Neoplasms
Restoration of E-rosette formation by bestatin in patients with bladder cancer.
Uterine Cervical Neoplasms
[Dynamics of the changes in cytosol aminopeptidase, aminopeptidase I (microsomal) and gamma-glutamyltransferase activities during brachytherapy of cancer of the uterine cervix and corpus]
Ventricular Dysfunction, Left
Heart rate turbulence after atrial and ventricular premature beats: relation to left ventricular function and coupling intervals.
Whooping Cough
GTP-binding protein couples with metabotropic glutamate receptor in bovine retinal on-bipolar cell.
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0.00006 - 0.000077
1,10-phenanthroline
0.0003
4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
Homo sapiens
pH and temperature not specified in the publication
0.01
abexinostat
Homo sapiens
above, pH and temperature not specified in the publication
0.00000316 - 0.00000402
arphamenine A
0.0000007 - 0.00000155
Arphamenine B
0.01
belinostat
Homo sapiens
above, pH and temperature not specified in the publication
0.00000349 - 0.0005
bestatin
0.01
CUDC-101
Homo sapiens
above, pH and temperature not specified in the publication
0.01
entinostat
Homo sapiens
above, pH and temperature not specified in the publication
0.01
givinostat
Homo sapiens
above, pH and temperature not specified in the publication
0.01
JNJ-26481585
Homo sapiens
above, pH and temperature not specified in the publication
0.01
mocetinostat
Homo sapiens
above, pH and temperature not specified in the publication
0.01
N-(6-(2-aminophenylamino)-6-oxyhexyl)-4-methylbenzamide
Homo sapiens
above, pH and temperature not specified in the publication
0.01
panobinostat
Homo sapiens
above, pH and temperature not specified in the publication
0.01
pracinostat
Homo sapiens
above, pH and temperature not specified in the publication
0.01
resminostat
Homo sapiens
above, pH and temperature not specified in the publication
0.01
rocilinostat
Homo sapiens
above, pH and temperature not specified in the publication
0.0044
scriptaid
Homo sapiens
pH and temperature not specified in the publication
0.00167
suberanilohydroxamic acid
Homo sapiens
pH and temperature not specified in the publication
-
0.01
trichostatin A
Homo sapiens
above, pH and temperature not specified in the publication
0.01
tubacin
Homo sapiens
above, pH and temperature not specified in the publication
0.01
Valproate
Homo sapiens
above, pH and temperature not specified in the publication
0.00000391 - 0.00000592
ZnCl2
7.77
[(2Z)-3-[2-(6-methyl-4-oxo-1,2,3-benzotriazin-3(4H)-yl)ethyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
Homo sapiens
pH 7.5, 22°C
7.9
[(2Z)-3-[2-(7-bromo-4-oxo-1,2,3-benzotriazin-3(4H)-yl)ethyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
Homo sapiens
pH 7.5, 22°C
7.39
[(2Z)-3-[2-(7-chloro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)ethyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
Homo sapiens
pH 7.5, 22°C
12.09
[(2Z)-3-[5-(6-methyl-4-oxo-1,2,3-benzotriazin-3(4H)-yl)pentyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
Homo sapiens
pH 7.5, 22°C
1.71
[(2Z)-3-[5-(7-bromo-4-oxo-1,2,3-benzotriazin-3(4H)-yl)pentyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
Homo sapiens
pH 7.5, 22°C
2.17
[(2Z)-3-[5-(7-chloro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)pentyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
Homo sapiens
pH 7.5, 22°C
7.9
[(2Z)-3-[5-(7-fluoro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)pentyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
Homo sapiens
pH 7.5, 22°C
3.87
[(2Z)-3-[6-(6-chloro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)hexyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
Homo sapiens
pH 7.5, 22°C
7.19
[(2Z)-3-[6-(6-methyl-4-oxo-1,2,3-benzotriazin-3(4H)-yl)hexyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
Homo sapiens
pH 7.5, 22°C
6.82
[(2Z)-3-[6-(7-bromo-4-oxo-1,2,3-benzotriazin-3(4H)-yl)hexyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
Homo sapiens
pH 7.5, 22°C
1.3
[(2Z)-3-[6-(7-chloro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)hexyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
Homo sapiens
pH 7.5, 22°C
12.27
[(2Z)-3-[6-(7-fluoro-4-oxo-1,2,3-benzotriazin-3(4H)-yl)hexyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
Homo sapiens
pH 7.5, 22°C
13.53
[(2Z)-3-[6-(7-methoxy-4-oxo-1,2,3-benzotriazin-3(4H)-yl)hexyl]-4-oxo-1,3-thiazolidin-2-ylidene]cyanamide
Homo sapiens
pH 7.5, 22°C
10.11
[(2Z)-4-oxo-3-[2-[4-oxo-6-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]ethyl]-1,3-thiazolidin-2-ylidene]cyanamide
Homo sapiens
pH 7.5, 22°C
14.89
[(2Z)-4-oxo-3-[5-[4-oxo-6-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]pentyl]-1,3-thiazolidin-2-ylidene]cyanamide
Homo sapiens
pH 7.5, 22°C
7.7
[(2Z)-4-oxo-3-[6-[4-oxo-6-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]hexyl]-1,3-thiazolidin-2-ylidene]cyanamide
Homo sapiens
pH 7.5, 22°C
0.00006
1,10-phenanthroline
Homo sapiens
-
pH 7.4, 37°C, mutant Q169N
0.000077
1,10-phenanthroline
Homo sapiens
-
pH 7.4, 37°C, wild-type
0.00000316
arphamenine A
Homo sapiens
-
pH 7.4, 37°C, mutant Q169N
0.00000373
arphamenine A
Homo sapiens
-
pH 7.4, 37°C, wild-type
0.00000402
arphamenine A
Homo sapiens
wild type enzyme, at pH 7.4 and 37°C
0.0000007
Arphamenine B
Homo sapiens
wild type enzyme, at pH 7.4 and 37°C
0.00000072
Arphamenine B
Homo sapiens
-
pH 7.4, 37°C, wild-type
0.00000155
Arphamenine B
Homo sapiens
-
pH 7.4, 37°C, mutant Q169N
0.00000349
bestatin
Homo sapiens
-
pH 7.4, 37°C, wild-type
0.00000382
bestatin
Homo sapiens
wild type enzyme, at pH 7.4 and 37°C
0.000289
bestatin
Homo sapiens
-
pH 7.4, 37°C, mutant Q169N
0.0005
bestatin
Homo sapiens
pH 7.5, 22°C
0.00000391
ZnCl2
Homo sapiens
-
pH 7.4, 37°C, wild-type
0.00000592
ZnCl2
Homo sapiens
-
pH 7.4, 37°C, mutant Q169N
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Mendz, G.L.; McCall, M.N.; Kuchel, P.W.
Characterization of leukocyte enzymes involved in the release of amino acids in incubated blood cell lysates
J. Biol. Chem.
264
2108-2117
1989
Homo sapiens
brenda
Lauffart, B.; Mantle, D.
Rationalization of aminopeptidase activities in human skeletal muscle soluble extract
Biochim. Biophys. Acta
956
300-306
1988
Homo sapiens
brenda
Lauffart, B.; McDermott, J.; Jones, P.; Mantle, D.
Amino acid inhibition of aminopeptidases purified from human cerebral cortex
Biochem. Soc. Trans.
16
849-850
1988
Homo sapiens
-
brenda
Ishiura, S.; Yamamoto, T.; Yamamoto, M.; Nojima, M.; Aoyagi, T.; Sugita, H.
Human skeletal muscle contains two major aminopeptidases: an anion-activated aminopeptidase B and an aminopeptidase M-like enzyme
J. Biochem.
102
1023-1031
1987
Homo sapiens
brenda
Mantle, D.; Lauffart, B.; Pennington, R.J.T.
Purification and partial characterization of arginine aminopeptidases from human skeletal muscle
Biochem. Soc. Trans.
12
826-827
1984
Homo sapiens
-
brenda
Soederling, E.; Mkinen, K.K.
Modification of the Cl- -activated arginine aminopeptidases from rat liver and human erythrocytes: a comparative study
Arch. Biochem. Biophys.
220
11-21
1983
Homo sapiens, Rattus norvegicus
brenda
Soederling, E.
Substrate specificities of Cl- -activated arginine aminopeptidases from human and rat origin
Arch. Biochem. Biophys.
220
1-10
1983
Homo sapiens, Rattus norvegicus
brenda
Soederling, E.
Effect of Cl- on the function of the Cl- -activated arginine aminopeptidase purified from human erythrocytes
Arch. Biochem. Biophys.
216
105-115
1982
Homo sapiens
brenda
Maekinen, K.K.; Paunio, K.U.
Demonstration of aminopeptidase B in human periodontal tissues
Acta Chem. Scand.
24
1103-1104
1970
Homo sapiens
brenda
McDonald, J.K.; Barrett, A.J.
Soluble arginyl aminopeptidase
Mammalian Proteases, Academic Press
2
48-55
1986
Homo sapiens, Rattus norvegicus, Sus scrofa
-
brenda
Toldra, F.; Falkous, G.; Flores, M.; Mantle, D.
Comparison of aminopeptidase inhibition by amino acids in human and porcine skeletal muscle tissues in vitro
Comp. Biochem. Physiol. B
115
445-450
1996
Homo sapiens, Sus scrofa
-
brenda
Fukasawa, K.M.; Fukasawa, K.; Kanai, M.; Fujii, S.; Harada, M.
Molecular cloning and expression of rat liver aminopeptidase B
J. Biol. Chem.
271
30731-30735
1996
Homo sapiens, Rattus norvegicus
brenda
Yamada, M.; Sukenaga, Y.; Fujii, H.; Abe, F.; Takeuchi, T.
Purification and characterization of a ubenimex (Bestatin)-sensitive aminopeptidase B-like enzyme from K562 human chronic myeloid leukemia cells
FEBS Lett.
342
53-56
1994
Homo sapiens
brenda
Belbacene, N.; Mari, B.; Rossi, B.; Auberger, P.
Characterization and purification of T lymphocyte aminopeptidase B: a putative marker of T cell activation
Eur. J. Immunol.
23
1948-1955
1993
Homo sapiens
brenda
Nagata, Y.; Mizutani, S.; Nomura, S.; Kurauchi, O.; Kasugai, M.; Tomoda, Y.
Purification and properties of human placental aminopeptidase B
Enzyme
45
165-173
1991
Homo sapiens
brenda
Tanioka, T.; Hattori, A.; Masuda, S.; Nomura, Y.; Nakayama, H.; Mizutani, S.; Tsujimoto, M.
Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases
J. Biol. Chem.
278
32275-32283
2003
Homo sapiens (Q6P179), Homo sapiens
brenda
Saitoh, Y.; Koizumi, K.; Minami, T.; Sekine, K.; Sakurai, H.; Saiki, I.
A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells
Biol. Pharm. Bull.
29
709-712
2006
Homo sapiens
brenda
Foulon, T.; Cadel, S.; Piesse, C.; Cohen, P.
Aminopeptidase B
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds) Academic Press
1
328-332
2004
Homo sapiens, Mus musculus, Rattus norvegicus
-
brenda
Cadel, S.; Piesse, C.; Gouzy-Darmon, C.; Cohen, P.; Foulon, T.
Arginyl aminopeptidase
Proteases in Biology and Disease (Hooper, N. M. ; Lendeckel, U. ) Springer
2
113-126
2004
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
-
brenda
Pinyol, M.; Bea, S.; Pla, L.; Ribrag, V.; Bosq, J.; Rosenwald, A.; Campo, E.; Jares, P.
Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis
Blood
109
5422-5429
2007
Homo sapiens
brenda
Qu, H.Q.; Marchand, L.; Frechette, R.; Bacot, F.; Lu, Y.; Polychronakos, C.
No association of type 1 diabetes with a functional polymorphism of the LRAP gene
Mol. Immunol.
44
2135-2138
2007
Homo sapiens
brenda
Ogawa, Y.; Ohnishi, A.; Goto, Y.; Sakuma, Y.; Watanabe, J.; Hattori, A.; Tsujimoto, M.
Role of glutamine-169 in the substrate recognition of human aminopeptidase B
Biochim. Biophys. Acta
1840
1872-1881
2014
Homo sapiens
brenda
Ye, M.; Wysocki, J.; Gonzalez-Pacheco, F.R.; Salem, M.; Evora, K.; Garcia-Halpin, L.; Poglitsch, M.; Schuster, M.; Batlle, D.
Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2
Hypertension
60
730-740
2012
Homo sapiens, Mus musculus
brenda
Ohnishi, A.; Watanabe, J.; Ogawa, Y.; Goto, Y.; Hattori, A.; Tsujimoto, M.
Involvement of phenylalanine 297 in the construction of the substrate pocket of human aminopeptidase B
Biochemistry
54
6062-6070
2015
Homo sapiens (Q9H4A4), Homo sapiens
brenda
Zhang, F.; Wu, D.; Wang, G.; Hou, S.; Ou-Yang, P.; Huang, J.; Xu, X.
Synthesis and biological evaluation of novel 1,2,3-benzotriazin-4-one derivatives as leukotriene A4 hydrolase aminopeptidase inhibitors
Chin. Chem. Lett.
28
1044-1048
2017
Homo sapiens (P09960)
-
brenda
Lu, W.; Yao, X.; Ouyang, P.; Dong, N.; Wu, D.; Jiang, X.; Wu, Z.; Zhang, C.; Xu, Z.; Tang, Y.; Zou, S.; Liu, M.; Li, J.; Zeng, M.; Lin, P.; Cheng, F.; Huang, J.
Drug repurposing of histone deacetylase inhibitors that alleviate neutrophilic inflammation in acute lung injury and idiopathic pulmonary fibrosis via inhibiting leukotriene A4 hydrolase and blocking LTB4 biosynthesis
J. Med. Chem.
60
1817-1828
2017
Homo sapiens (P09960)
brenda