Reference on EC 3.4.11.2 - membrane alanyl aminopeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Delange, R.J.; Smith, E.L.
Leucine aminopeptidase and other N-terminal exopeptidases
The Enzymes, 2nd Ed. (Boyer, P. D. , Lardy, H. , Myrbck, K. , eds. )
3
81-118
1971
Sus scrofa
-
Luciani, N.; Marie-Claire, C.; Ruffet, E.; Beaumont, A.; Roques, B.P.; Fournie-Zaluski, M.C.
Characterization of Glu350 as a critical residue involved in the N-terminal amine binding site of aminopeptidase N (EC 3.4.11.2): insights into its mechanism of action
Biochemistry
37
686-692
1998
Homo sapiens, Sus scrofa
Schalk, C.; d'Orchymont, H.; Jauch, M.F.; Tarnus, C.
3-Amino-2-tetralone derivatives: novel potent and selective inhibitors of aminopeptidase-M (EC 3.4.11.2)
Arch. Biochem. Biophys.
311
42-46
1994
Sus scrofa
Menrad, A.; Speicher, D.; Wacker, J.; Herlyn, M.
Biochemical and functional characterization of aminopeptidase N expressed by human melanoma cells
Cancer Res.
53
1450-1455
1993
Homo sapiens
O'Callaghan B.; Synguelakis, M.; Le Gal La Salle, G.; Morel,N.
Characterization of aminopeptidase N from Torpedo marmorata kidney
Biol. Cell.
81
121-130
1994
Torpedo marmorata
Terashima, H.; Bunnett, N.W.
Purification and characterization of aminopeptidase M from muscle and mucosa of the pig intestine
J. Gastroenterol.
30
696-704
1995
Sus scrofa
Lalu, K.; Lampelo, S.; Vanha-Perttula, T.
Characterization of three aminopeptidases purified from maternal serum
Biochim. Biophys. Acta
873
190-197
1986
Homo sapiens
Exterkate, F.A.; De Jong.M.; De Veer G.J.C.M.; Baankreis, R.
Location and characterization of aminopeptidase N in Lactococcus lactis subsp. cremoris HP
Appl. Microbiol. Biotechnol.
37
46-54
1992
Lactococcus lactis
-
Tate, S.S.
Microvillus membrane peptidases that catalyze hydrolysis of cysteinylglycine and its derivatives
Methods Enzymol.
113
471-484
1985
Rattus norvegicus
Gros, C.; Giros, B.; Schwartz, J.C.
Identification of aminopeptidase M as an enkephalin-inactivating enzyme in rat cerebral membranes
Biochemistry
24
2179-2185
1985
Rattus norvegicus
Midwinter R.G.; Pritchard, G.G.
Aminopeptidase N from Streptococcus salivarius subsp. thermophilus NCDO 573: purification and properties
J. Appl. Bacteriol.
77
288-295
1994
Streptococcus salivarius
Erickson, R.H.; Kim, Y.S.
Interaction of purified brush-border membrane aminopeptidase N and dipeptidyl peptidase IV with lectin-sepharose derivatives
Biochim. Biophys. Acta
743
37-42
1983
Rattus norvegicus
Kozak, E.M.; Tate, S.S.
Glutathione-degrading enzymes of microvillus membranes
J. Biol. Chem.
257
6322-6327
1982
Rattus norvegicus
Huang, K.; Takahara, S.; Kinouchi, T.; Takeyama, M.; Ishida, T.; Ueyama, H.; Nishi, K.; Ohkubo, I.
Alanyl aminopeptidase from human seminal plasma: purification, characterization, and immunohistochemical localization in the male genital tract
J. Biochem.
122
779-787
1997
Homo sapiens
McClellan, J.B.; Garner, C.W.
Purification and properties of human intestine alanine aminopeptidase
Biochim. Biophys. Acta
613
160-167
1980
Homo sapiens
Sjstrm, H.; Noren, O.; Jeppesen, L.; Staun, M.; Svensson, B.; Christiansen, L.
Purification of different amphiphilic forms of a microvillus aminopeptidase from pig small intestine using immunoadsorbent chromatography
Eur. J. Biochem.
88
503-511
1978
Sus scrofa
Hua, G.; Tsukamoto, K.; Taguchi, R.; Tomita, M.; Miyajima, S.; Ikezawa, H.
Characterization of aminopeptidase N from the brush border membrane of the larvae midgut of silkworm, Bombyx mori as a zinc enzyme [published erratum appears in Biochim Biophys Acta 1998 Sep 8;1387(1-2):486
Biochim. Biophys. Acta
1383
301-310
1998
Bombyx mori
Feracci, H.; Maroux, S.
Rabbit intestinal aminopeptidase N. Purification and molecular properties
Biochim. Biophys. Acta
599
448-463
1980
Oryctolagus cuniculus
Gray, G.M.; Santiago, N.A.
Intestinal surface amino-oligopeptidases. I. Isolation of two weight isomers and their subunits from rat brush border
J. Biol. Chem.
252
4922-4928
1977
Rattus norvegicus
Maroux, S.; Louvard, D.; Baratti, J.
The aminopeptidase from hog intestinal brush border
Biochim. Biophys. Acta
321
282-295
1973
Sus scrofa
Wachsmuth, E.D.; Fritze, I.; Pfleiderer, G.
An aminopeptidase occurring in pig kidney. I. An improved method of preparation. Physical and enzymic properties
Biochemistry
5
169-174
1966
Sus scrofa
Kim, Y.S.; Brophy, E.J.
Rat intestinal brush border membrane peptidases. I. Solubilization, purification, and physicochemical properties of two different forms of the enzyme
J. Biol. Chem.
251
3199-3205
1976
Rattus norvegicus
Wachsmuth, E.D.; Fritze, I.; Pfleiderer, G.
An aminopeptidase occurring in pig kidney. II. A study on the mechanism of the hydrolysis
Biochemistry
5
175-182
1966
Sus scrofa
Olsen, J.; Cowell, G.M.; Konigshofer, E.; Danielsen, E.M.; Moller, J.; Laustsen, L.; Hansen, O.C.; Welinder, K.G.; Engberg, J.; Hunziker, W.; Spiess, M.; Sjstrm, H.; Noren, O.
Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA
FEBS Lett.
238
307-314
1988
Homo sapiens
Tokioka-Terao, M.; Hiwada, K.; Kokubu, T.
Purification and characterization of aminopeptidase N from human plasma
Enzyme
32
65-75
1984
Homo sapiens
Wojnarowska, F.; Gray, G.M.
Intestinal surface peptide hydrolases: identification and characterization of three enzymes from rat brush border
Biochim. Biophys. Acta
403
147-160
1975
Rattus norvegicus
Tomita, M.; Obara, H.; Takesue, Y.; Tamura, H.O.; Miyajima, S.; Taguchi, R.; Ikezawa, H.
The interaction of human serum albumin in the native and fully reduced states with apolipoprotein E, serum amyloid protein and very low density lipoproteins from human plasma
Int. J. Biochem.
26
977-986
1994
Bombyx mori
Watt, V.M.; Yip, C.C.
Amino acid sequence deduced from a rat kidney cDNA suggests it encodes the Zn-peptidase aminopeptidase N
J. Biol. Chem.
264
5480-5487
1989
Rattus norvegicus
Denholf, P.; Hendrickx, K.; Van Damme, J.; Jansens, S.; Peferoen, M.; Degheele, D.; Van Rie, J.
Cloning and characterization of Manduca sexta and Plutella xylostella midgut aminopeptidase N enzymes related to Bacillus thuringiensis toxin-binding proteins
Eur. J. Biochem.
248
748-761
1997
Manduca sexta (P91885), Manduca sexta, Plutella xylostella (P91887), Plutella xylostella
Lee, M.K.; You, T.H.; Young, B.A.; Cotrill, J.A.; Valaitis, A.P.; Dean, D.H.
Aminopeptidase N purified from gypsy moth brush border membrane vesicles is a specific receptor for Bacillus thuringiensis CryIAc toxin
Appl. Environ. Microbiol.
62
2845-2849
1996
Lymantria dispar
Malfroy, B.; Kado-Fong, H.; Gros, C.; Giros, B.; Schwartz, J.C.; Hellmiss, R.
Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: a member of a super family of zinc-metallohydrolases
Biochem. Biophys. Res. Commun.
161
236-241
1989
Rattus norvegicus
Yang, X.F.; Milhiet, P.E.; Gaudoux, F.; Crine, P.; Boileau, G.
Complete sequence of rabbit kidney aminopeptidase N and mRNA localization in rabbit kidney by in situ hybridization
Biochem. Cell Biol.
71
278-287
1993
Oryctolagus cuniculus
Yoshimoto, T.; Tamesa, Y.; Gushi, K.; Murayama, N.; Tsuru, D.
An aminopeptidase N from Escherichia coli HB1010: Purification and demonstration that the enzyme possesses arylamidase and peptidase activities
Agric. Biol. Chem.
52
217-225
1988
Escherichia coli
-
McCaman, M.T.; Villarejo, M.R.
Structured and catalytic properties of peptidase N from Escherichia coli K-12
Arch. Biochem. Biophys.
213
384-394
1982
Escherichia coli
Noble, F.; Luciani, N.; Da Nacimento, S.; Lai-Kuen, R.; Bischoff, L.; Chen, H.; Fournie-Zaluski, M.C.; Roques, B.P.
Binding propeties of a highly potent and selecive iodinated aminopeptidase N inhibitor appropriate for radioautography
FEBS Lett.
467
81-86
2000
Rattus norvegicus, Sus scrofa
Nakanishi, K.; Yaoi, K.; Nagino, Y.; Hara, H.; Kitami, M.; Atsumi, S.; Miura, N.; Sato, R.
Aminopeptidase N isoforms from the midgut of Bombyx mori and Plutella xylostella - their classification and the factors that determine their binding specificity to Bacillus thuringiensis Cry1A toxin
FEBS Lett.
519
215-220
2002
Bombyx mori (Q8T7M0), Bombyx mori, Plutella xylostella (Q9U8B0), Plutella xylostella
Contreras-Rodriguez, A.; Ramirez-Zavala, B.; Contreras, A.; Schurig, G.G.; Sriranganathan, N.; Lopez-Merino, A.
Purification and characterization of an immunogenic aminopeptidase of Brucella melitensis
Infect. Immun.
71
5238-5244
2003
Brucella melitensis (Q8YG38), Brucella melitensis, Brucella melitensis 16M (Q8YG38)
Pootanakit, K.; Angsuthanasombat, C.; Panyim, S.
Identification of two isoforms of aminopeptidase N in Aedes aegypti larval midgut
J. Biochem. Mol. Biol.
36
508-513
2003
Aedes aegypti (Q95P62), Aedes aegypti (Q95PB9), Aedes aegypti
Byun, T; Tang, M.; Sloma, A.; Brown, K.M.; Marumoto, C.; Fujii, M.; Blinkovsky, A.M.
Aminopeptidase from Sphingomonas capsulata
J. Biol. Chem.
276
17902-17907
2001
Novosphingobium capsulatum, Novosphingobium capsulatum IFO 12533
Grembecka, J.; Mucha, A.; Cierpicki, T.; Kafarski, P.
The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity
J. Med. Chem.
46
2641-2655
2003
Sus scrofa
Bauvois, B.; Puiffe, M.L.; Bongui, J.B.; Paillat, S.; Monneret, C.; Dauzonne, D.
Synthesis and biological evaluation of novel flavone-8-acetic acid derivatives as reversible inhibitors of aminopeptidase N/CD13
J. Med. Chem.
46
3900-3913
2003
Homo sapiens
Acartuerk, F.; Parlatan, Z.I.; Saracoglu, O.F.
Comparison of vaginal aminopeptidase enzymatic activities in various animals and in humans
J. Pharm. Pharmacol.
53
1499-1504
2001
Cavia porcellus, Homo sapiens, Oryctolagus cuniculus, Ovis aries, Rattus norvegicus
Bernkop-Schnurch, A.; Zarti, H.; Walker, G.F.
Thiolation of polycarbophil enhances its inhibition of intestinal brush border membrane bound aminopeptidase N
J. Pharm. Sci.
90
1907-1914
2001
Sus scrofa
Irazusta, J.; Larrinaga, G.; Agirregoitia, N.; Varona, A.; Casis, L.
Effects of morphine administration and its withdrawal on rat brain aminopeptidase activities
Regul. Pept.
110
225-230
2003
Rattus norvegicus
Barth, A.; Siekel, P.; Sedlarova, E.; Valent, A.; Tokhtaeva, E.
Study of immobilized and extracellular aminopeptidases of watermelon
Acta Histochem.
107
253-259
2005
Citrullus lanatus subsp. vulgaris
Jankiewicz, U.; Bielawski, W.
The properties and functions of bacterial aminopeptidases
Acta Microbiol. Pol.
52
217-231
2003
Escherichia coli, Latilactobacillus curvatus, Lactobacillus delbrueckii, Lactococcus lactis, Pseudomonas aeruginosa, Pseudomonas fluorescens, Streptococcus thermophilus
Taracha, E.; Habrat, B.; Lehner, M.; Wislowska, A.; Woronowicz, B.T.; Bogulas, M.; Charewicz, J.; Markuszewski, C.; Plaznik, A.
Alanine aminopeptidase activity in urine: a new marker of chronic alcohol abuse?
Alcohol. Clin. Exp. Res.
28
729-735
2004
Homo sapiens
Lendeckel, U.; Bukowska, A.; Laettig, J.H.; Brandt, W.
Alanyl-aminopeptidases in human T cells. Structures and functions
Aminopeptidases in Biology and Disease (Hooper, N. M. ; Lendechel, U. , eds. )
2
201-227
2004
Homo sapiens
-
Iturrioz, X.; Reaux-Le Goazigo, A.; Llorens-Cortes, C.
Aminopeptidase inhibitors as anti-hypertensive drugs
Aminopeptidases in Biology and Disease (Hooper, N. M. ; Lendechel, U. , eds. )
2
229-250
2004
Homo sapiens
-
Atsumi, S.; Mizuno, E.; Hara, H.; Nakanishi, K.; Kitami, M.; Miura, N.; Tabunoki, H.; Watanabe, A.; Sato, R.
Location of the Bombyx mori aminopeptidase N type 1 binding site on Bacillus thuringiensis Cry1Aa toxin
Appl. Environ. Microbiol.
71
3966-3977
2005
Bombyx mori
Thielitz, A.; Bukowska, A.; Wolke, C.; Vetter, R.; Lendeckel, U.; Wrenger, S.; Hashimoto, Y.; Ansorge, S.; Gollnick, H.; Reinhold, D.
Identification of extra- and intracellular alanyl aminopeptidases as new targets to modulate keratinocyte growth and differentiation
Biochem. Biophys. Res. Commun.
321
795-801
2004
Homo sapiens
Riemann, D.; Tcherkes, A.; Hansen, G.H.; Wulfaenger, J.; Blosz, T.; Danielsen, E.M.
Functional co-localization of monocytic aminopeptidase N/CD13 with the Fc gamma receptors CD32 and CD64
Biochem. Biophys. Res. Commun.
331
1408-1412
2005
Homo sapiens
Jardinaud, F.; Banisadr, G.; Noble, F.; Melik-Parsadaniantz, S.; Chen, H.; Dugave, C.; Laplace, H.; Rostene, W.; Fournie-Zaluski, M.C.; Roques, B.P.; Popovici, T.
Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography
Biochimie
86
105-113
2004
Rattus norvegicus
Saitoh, Y.; Koizumi, K.; Minami, T.; Sekine, K.; Sakurai, H.; Saiki, I.
A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells
Biol. Pharm. Bull.
29
709-712
2006
Homo sapiens
Lee, J.; Shim, J.S.; Jung, S.A.; Lee, S.T.; Kwon, H.J.
N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamic acid-based inhibitor of aminopeptidase N and its anti-angiogenic activity
Bioorg. Med. Chem. Lett.
15
181-183
2005
Bos taurus
Yamauchi, Y.; Ejiri, Y.; Tanaka, K.
Purification of an aminopeptidase preferentially releasing N-terminal alanine from cucumber leaves and its identification as a plant aminopeptidase N
Biosci. Biotechnol. Biochem.
65
2802-2805
2001
Cucumis sativus
Migita, K.; Nishimura, T.
Purification and characterization of a Cl--activated aminopeptidase from bovine skeletal muscle
Biosci. Biotechnol. Biochem.
70
1110-1117
2006
Bos taurus
Fontijn, D.; Duyndam, M.C.; van Berkel, M.P.; Yuana, Y.; Shapiro, L.H.; Pinedo, H.M.; Broxterman, H.J.; Boven, E.
CD13/Aminopeptidase N overexpression by basic fibroblast growth factor mediates enhanced invasiveness of 1F6 human melanoma cells
Br. J. Cancer
94
1627-1636
2006
Homo sapiens
Shim, J.S.; Lee, H.S.; Shin, J.; Kwon, H.J.
Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro
Cancer Lett.
203
163-169
2004
Sus scrofa
Aozuka, Y.; Koizumi, K.; Saitoh, Y.; Ueda, Y.; Sakurai, H.; Saiki, I.
Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice
Cancer Lett.
216
35-42
2004
Mus musculus
Fukasawa, K.; Fujii, H.; Saitoh, Y.; Koizumi, K.; Aozuka, Y.; Sekine, K.; Yamada, M.; Saiki, I.; Nishikawa, K.
Aminopeptidase N (APN/CD13) is selectively expressed in vascular endothelial cells and plays multiple roles in angiogenesis
Cancer Lett.
243
135-143
2006
Homo sapiens (P15144), Homo sapiens
Umetsu, H.; Arai, M.; Ota, T.; Kudo, R.; Sugiura, H.; Ishiyama, H.; Sasaki, K.
Purification and properties of an aminopeptidase from the mid-gut gland of scallop (Patinopecten yessoensis)
Comp. Biochem. Physiol. B
136B
935-942
2003
Mizuhopecten yessoensis
-
Xu, W.; Li, Q.
Progress in the development of aminopeptidase N (APN/CD13) inhibitors
Curr. Med. Chem.
5
281-301
2005
Homo sapiens
Sihn, G.; Savary, K.; Michaud, A.; Fournie-Zaluski, M.C.; Roques, B.P.; Corvol, P.; Gasc, J.M.
Aminopeptidase N during the ontogeny of the chick
Differentiation
74
119-128
2006
Gallus gallus
Stephens, E.; Sugars, J.; Maslen, S.L.; Williams, D.H.; Packman, L.C.; Ellar, D.J.
The N-linked oligosaccharides of aminopeptidase N from Manduca sexta: site localization and identification of novel N-glycan structures
Eur. J. Biochem.
271
4241-4258
2004
Manduca sexta
Wang, G.R.; Liang, G.M.; Wu, K.M.; Guo, Y.Y.
Gene cloning and sequencing of aminopeptidase N3, a putative receptor for Bacillus thuringiensis insecticidal Cry1Ac toxin in Helicoverpa armigera (Lepidoptera: Noctuidae)
Eur. J. Entomol.
102
13-19
2005
Helicoverpa armigera (Q95UF9)
-
Caprioglio, D.R.
Yeast aminopeptidases Ape2, Aap1' and Yin7
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds)
1
316-318
2004
Saccharomyces cerevisiae
-
Turner, A.J.
Membrane alanyl aminopeptidase
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. )
1
289-294
2004
Oryctolagus cuniculus, Homo sapiens, Lactococcus lactis, Lymantria dispar, Rattus norvegicus, Sus scrofa
-
Adang, M.J.
Insect aminopeptidase N
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. )
1
296-299
2004
Bombyx mori, Drosophila melanogaster, Heliothis virescens, Manduca sexta, Plutella xylostella, Tenebrio molitor, Epiphyas postvittana, Helicoverpa punctigera
-
Butler, M.J.
Aminopeptidase N (Streptomyces lividans)
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. )
1
322-323
2004
Streptomyces lividans
-
Gabrilovac, J.; Cupic, B.; Breljak, D.; Zekusic, M.; Boranic, M.
Expression of CD13/aminopeptidase N and CD10/neutral endopeptidase on cultured human keratinocytes
Immunol. Lett.
91
39-47
2004
Homo sapiens
Wang, P.; Zhang, X.; Zhang, J.
Molecular characterization of four midgut aminopeptidase N isozymes from the cabbage looper, Trichoplusia ni
Insect Biochem. Mol. Biol.
35
611-620
2005
Trichoplusia ni
Chang, Y.W.; Chen, S.C.; Cheng, E.C.; Ko, Y.P.; Lin, Y.C.; Kao, Y.R.; Tsay, Y.G.; Yang, P.C.; Wu, C.W.; Roffler, S.R.
CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells
Int. J. Cancer
116
243-252
2005
Homo sapiens
Vijgen, L.; Keyaerts, E.; Zlateva, K.; Van Ranst, M.
Identification of six new polymorphisms in the human coronavirus 229E receptor gene (aminopeptidase N/CD13)
Int. J. Infect. Dis.
8
217-222
2004
Homo sapiens (P15144), Homo sapiens
Kehlen, A.; Geisler, M.; Olsen, J.; Sablotzki, A.; Langner, J.; Riemann, D.
IL-10 and TGF-beta differ in their regulation of aminopeptidase N/CD13 expression in monocytes
Int. J. Mol. Med.
13
877-882
2004
Homo sapiens
Shitomi, Y.; Hayakawa, T.; Hossain, D.M.; Higuchi, M.; Miyamoto, K.; Nakanishi, K.; Sato, R.; Hori, H.
A novel 96-kDa aminopeptidase localized on epithelial cell membranes of Bombyx mori midgut, which binds to Cry1Ac toxin of Bacillus thuringiensis
J. Biochem.
139
223-233
2006
Bombyx mori
Alfalah, M.; Krahn, M.P.; Wetzel, G.; von Horsten, S.; Wolke, C.; Hooper, N.; Kalinski, T.; Krueger, S.; Naim, H.Y.; Lendeckel, U.
A mutation in aminopeptidase N (CD13) isolated from a patient suffering from leukemia leads to an arrest in the endoplasmic reticulum
J. Biol. Chem.
281
11894-11900
2006
Homo sapiens
Cowburn, A.S.; Sobolewski, A.; Reed, B.J.; Deighton, J.; Murray, J.; Cadwallader, K.A.; Bradley, J.R.; Chilvers, E.R.
Aminopeptidase N (CD13) regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils
J. Biol. Chem.
281
12458-12467
2006
Homo sapiens
Roecken, C.; Licht, J.; Roessner, A.; Carl-McGrath, S.
Canalicular immunostaining of aminopeptidase N (CD13) as a diagnostic marker for hepatocellular carcinoma
J. Clin. Pathol.
58
1069-1075
2005
Homo sapiens
Agirregoitia, N.; Laiz-Carrion, R.; Varona, A.; Rio, M.P.; Mancera, J.M.; Irazusta, J.
Distribution of peptidase activity in teleost and rat tissues
J. Comp. Physiol. B
175
433-444
2005
Oncorhynchus mykiss, Rattus norvegicus, Sparus aurata
Mabjeesh, S.J.; Gal-Garber, O.; Milgram, J.; Feuermann, Y.; Cohen-Zinder, M.; Shamay, A.
Aminopeptidase N gene expression and abundance in caprine mammary gland is influenced by circulating plasma peptide
J. Dairy Sci.
88
2055-2064
2005
Capra hircus
Jamadar, V.K.; Jamdar, S.N.; Dandekar, S.P.; Harikumar, P.
Purification and characterization of aminopeptidase from chicken intestine
J. Food Sci.
68
438-443
2003
Gallus gallus
-
Mina-Osorio, P.; Ortega, E.
Aminopeptidase N (CD13) functionally interacts with FcgammaRs in human monocytes
J. Leukocyte Biol.
77
1008-1017
2005
Homo sapiens
Mina-Osorio, P.; Shapiro, L.H.; Ortega, E.
CD13 in cell adhesion: aminopeptidase N (CD13) mediates homotypic aggregation of monocytic cells
J. Leukocyte Biol.
79
719-730
2006
Homo sapiens
Fetterer, R.H.; Miska, K.B.; Barfield, R.C.
Partial purification and characterization of an aminopeptidase from Eimeria tenella
J. Parasitol.
91
1280-1286
2005
Eimeria tenella
Kunii, R.; Nemoto, E.; Kanaya, S.; Tsubahara, T.; Shimauchi, H.
Expression of CD13/aminopeptidase N on human gingival fibroblasts and up-regulation upon stimulation with interleukin-4 and interleukin-13
J. Periodontal Res.
40
138-146
2005
Homo sapiens
Zhao, G.M.; Zhou, G.H.; Tian, W.; Xu, X.L.; Wang, Y.L.; Luo, X.
Changes of alanyl aminopeptidase activity and free amino acid contents in biceps femoris during processing of Jinhua ham
Meat Sci.
71
612-619
2005
Sus scrofa
Bauvois, B.; Dauzonne, D.
Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects
Med. Res. Rev.
26
88-130
2006
Homo sapiens
Masler, E.P.
Comparison of alanine aminopeptidase activities in Heterodera glycines and Caenorhabditis elegans
Nematology
6
223-229
2004
Caenorhabditis elegans, Heterodera glycines
-
Witek, B.; Ochwanowska, E.; Kolataj, A.; Krol, T.; Baranowska, D.; Rafay, J.
Insulin-induced changes of proteolytic activity of the lysosomal enzymes
Neuroendocrinol. Lett.
25
83-86
2004
Mus musculus
Ichimura, E.; Yamada, M.; Nishikawa, K.; Abe, F.; Nakajima, T.
Immunohistochemical expression of aminopeptidase N (CD13) in human lung squamous cell carcinomas, with special reference to bestatin adjuvant therapy
Pathol. Int.
56
296-300
2006
Homo sapiens
Gasparello-Clemente, E.; Casis, L.; Varona, A.; Gil, J.; Irazusta, J.; Silveira, P.F.
Aminopeptidases in visceral organs during alterations in body fluid volume and osmolality
Peptides
24
1367-1372
2003
Rattus norvegicus
Krstanovic, M.; Brgles, M.; Halassy, B.; Frkanec, R.; Vrdoljak, A.; Branovic, K.; Tomasic, J.; Benedetti, F.
Purification and characterization of L,(L/D)-aminopeptidase from guinea pig serum
Prep. Biochem. Biotechnol.
36
175-195
2006
Cavia porcellus
Golich, F.C.; Han, M.; Crowder, M.W.
Over-expression, purification, and characterization of aminopeptidase N from Escherichia coli
Protein Expr. Purif.
47
634-639
2006
Escherichia coli
Kasman, L.M.
CD13/aminopeptidase N and murine cytomegalovirus infection
Virology
334
1-9
2005
Homo sapiens, Mus musculus
Wentworth, D.E.; Tresnan, D.B.; Turner, B.C.; Lerman, I.R.; Bullis, B.; Hemmila, E.M.; Levis, R.; Shapiro, L.H.; Holmes, K.V.
Cells of human aminopeptidase N (CD13) transgenic mice are infected by human coronavirus-229E in vitro, but not in vivo
Virology
335
185-197
2005
Homo sapiens (P15144), Homo sapiens
Reinhold, D.; Biton, A.; Goihl, A.; Pieper, S.; Lendeckel, U.; Faust, J.; Neubert, K.; Bank, U.; Taeger, M.; Ansorge, S.; Brocke, S.
Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses
Ann. N. Y. Acad. Sci.
1110
402-409
2007
Homo sapiens, Mus musculus
Albrecht, S.; Defoin, A.; Salomon, E.; Tarnus, C.; Wetterholm, A.; Haeggstroem, J.Z.
Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors
Bioorg. Med. Chem.
14
7241-7257
2006
Sus scrofa
Bank, U.; Tadje, J.; Taeger, M.; Wolke, C.; Bukowska, A.; Ittenson, A.; Reinhold, D.; Helmuth, M.; Ansorge, S.; Shakespeare, A.; Vieth, M.; Malfertheiner, P.; Naumann, M.; Lendeckel, U.
Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-beta1 and ameliorates acute colitis in mice
Int. J. Mol. Med.
20
483-492
2007
Mus musculus
Thielitz, A.; Reinhold, D.; Vetter, R.; Bank, U.; Helmuth, M.; Hartig, R.; Wrenger, S.; Wiswedel, I.; Lendeckel, U.; Kaehne, T.; Neubert, K.; Faust, J.; Zouboulis, C.C.; Ansorge, S.; Gollnick, H.
Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation
J. Invest. Dermatol.
127
1042-1051
2007
Homo sapiens
Flipo, M.; Beghyn, T.; Leroux, V.; Florent, I.; Deprez, B.P.; Deprez-Poulain, R.F.
Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents
J. Med. Chem.
50
1322-1334
2007
Pseudomonas aeruginosa
Banegas, I.; Prieto, I.; Vives, F.; Alba, F.; de Gasparo, M.; Segarra, A.B.; Hermoso, F.; Duran, R.; Ramirez, M.
Brain aminopeptidases and hypertension
J. Renin Angiotensin Aldosterone Syst.
7
129-134
2006
Rattus norvegicus
Onohara, Y.; Nakajima, Y.; Ito, K.; Xu, Y.; Nakashima, K.; Ito, T.; Yoshimoto, T.
Crystallization and preliminary X-ray characterization of aminopeptidase N from Escherichia coli
Acta Crystallogr. Sect. F
62
699-701
2006
Escherichia coli (P04825), Escherichia coli
Kotlo, K.; Shukla, S.; Tawar, U.; Skidgel, R.A.; Danziger, R.S.
Aminopeptidase N reduces basolateral Na+ -K+ -ATPase in proximal tubule cells
Am. J. Physiol. Renal Physiol.
293
F1047-F1053
2007
Homo sapiens (P15144)
Garde, S.V.; Forte, A.J.; Ge, M.; Lepekhin, E.A.; Panchal, C.J.; Rabbani, S.A.; Wu, J.J.
Binding and internalization of NGR-peptide-targeted liposomal doxorubicin (TVT-DOX) in CD13-expressing cells and its antitumor effects
Anticancer Drugs
18
1189-1200
2007
Homo sapiens
Hatanaka, T.; Arima, J.; Uraji, M.; Uesugi, Y.; Iwabuchi, M.
Characterization, cloning, sequencing, and expression of an aminopeptidase N from Streptomyces sp. TH-4
Appl. Microbiol. Biotechnol.
74
347-356
2007
Streptomyces sp., Streptomyces sp. TH-4
Buehler, A.; van Zandvoort, M.A.; Stelt, B.J.; Hackeng, T.M.; Schrans-Stassen, B.H.; Bennaghmouch, A.; Hofstra, L.; Cleutjens, J.P.; Duijvestijn, A.; Smeets, M.B.; de Kleijn, D.P.; Post, M.J.; de Muinck, E.D.
cNGR: a novel homing sequence for CD13/APN targeted molecular imaging of murine cardiac angiogenesis in vivo
Arterioscler. Thromb. Vasc. Biol.
26
2681-2687
2006
Mus musculus
Mina-Osorio, P.; Soto-Cruz, I.; Ortega, E.
A role for galectin-3 in CD13-mediated homotypic aggregation of monocytes
Biochem. Biophys. Res. Commun.
353
605-610
2007
Homo sapiens
Yang, E.; Shim, J.S.; Woo, H.J.; Kim, K.W.; Kwon, H.J.
Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3
Biochem. Biophys. Res. Commun.
363
336-341
2007
Homo sapiens, Mus musculus
Li, Q.; Fang, H.; Xu, W.
Novel 3-galloylamido-N-substituted-2,6-piperidinedione-N-acetamide peptidomimetics as metalloproteinase inhibitors
Bioorg. Med. Chem. Lett.
17
2935-2938
2007
Sus scrofa
Budatha, M.; Meur, G.; Kirti, P.B.; Dutta Gupta, A.
Characterization of Bacillus thuringiensis Cry toxin binding novel GPI anchored aminopeptidase from fat body of the moth Spodoptera litura
Biotechnol. Lett.
29
1651-1657
2007
Spodoptera litura
Petrovic, N.; Schacke, W.; Gahagan, J.R.; OConor, C.A.; Winnicka, B.; Conway, R.E.; Mina-Osorio, P.; Shapiro, L.H.
CD13/APN regulates endothelial invasion and filopodia formation
Blood
110
142-150
2007
Homo sapiens
Proost, P.; Mortier, A.; Loos, T.; Vandercappellen, J.; Gouwy, M.; Ronsse, I.; Schutyser, E.; Put, W.; Parmentier, M.; Struyf, S.; Van Damme, J.
Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration
Blood
110
37-44
2007
Sus scrofa
Terauchi, M.; Kajiyama, H.; Shibata, K.; Ino, K.; Nawa, A.; Mizutani, S.; Kikkawa, F.
Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells
BMC Cancer
7
140
2007
Homo sapiens, Mus musculus
Tsukamoto, H.; Shibata, K.; Kajiyama, H.; Terauchi, M.; Nawa, A.; Kikkawa, F.
Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer
BMC Cancer
8
74
2008
Homo sapiens, Mus musculus
Tokuhara, T.; Hattori, N.; Ishida, H.; Hirai, T.; Higashiyama, M.; Kodama, K.; Miyake, M.
Clinical significance of aminopeptidase N in non-small cell lung cancer
Clin. Cancer Res.
12
3971-3978
2006
Homo sapiens
Demaegdt, H.; Lenaerts, P.J.; Swales, J.; De Backer, J.P.; Laeremans, H.; Le, M.T.; Kersemans, K.; Vogel, L.K.; Michotte, Y.; Vanderheyden, P.; Vauquelin, G.
Angiotensin AT4 receptor ligand interaction with cystinyl aminopeptidase and aminopeptidase N: [125I]angiotensin IV only binds to the cystinyl aminopeptidase apo-enzyme
Eur. J. Pharmacol.
546
19-27
2006
Homo sapiens
Contreras-Rodriguez, A.; Seleem, M.N.; Schurig, G.G.; Sriranganathan, N.; Boyle, S.M.; Lopez-Merino, A.
Cloning, expression and characterization of immunogenic aminopeptidase N from Brucella melitensis
FEMS Immunol. Med. Microbiol.
48
252-256
2006
Brucella melitensis (Q8YG38), Brucella melitensis, Brucella melitensis 16M (Q8YG38)
Vanderheyden, P.M.; Demaegdt, H.; Swales, J.; Lenaerts, P.J.; De Backer, J.P.; Vogel, L.K.; Vauquelin, G.
Synergistic inhibition of the enzymatic activity of aminopeptidase N by divalent metal ion chelators
Fundam. Clin. Pharmacol.
20
613-619
2006
Homo sapiens, Sus scrofa
Kawamura, J.; Shimada, Y.; Kitaichi, H.; Komoto, I.; Hashimoto, Y.; Kaganoi, J.; Miyake, M.; Yamasaki, S.; Kondo, K.; Imamura, M.
Clinicopathological significance of aminopeptidase N/CD13 expression in human gastric carcinoma
Hepatogastroenterology
54
36-40
2007
Homo sapiens
Padia, S.H.; Kemp, B.A.; Howell, N.L.; Siragy, H.M.; Fournie-Zaluski, M.C.; Roques, B.P.; Carey, R.M.
Intrarenal aminopeptidase N inhibition augments natriuretic responses to angiotensin III in angiotensin type 1 receptor-blocked rats
Hypertension
49
625-630
2007
Rattus norvegicus
Soeryapranata, E.; Powers, J.R.; Unlu, G.
Cloning and characterization of debittering peptidases, PepE, PepO, PepO2, PepO3, and PepN, of Lactobacillus helveticus WSU19
Int. Dairy J.
17
1096-1106
2007
Lactobacillus helveticus (Q076V2), Lactobacillus helveticus WSU19 (Q076V2)
Yamashita, M.; Kajiyama, H.; Terauchi, M.; Shibata, K.; Ino, K.; Nawa, A.; Mizutani, S.; Kikkawa, F.
Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo
Int. J. Cancer
120
2243-2250
2007
Homo sapiens, Mus musculus
Surowiak, P.; Drag, M.; Materna, V.; Suchocki, S.; Grzywa, R.; Spaczy?ski, M.; Dietel, M.; Oleksyszyn, J.; Zabel, M.; Lage, H.
Expression of aminopeptidase N/CD13 in human ovarian cancers
Int. J. Gynecol. Cancer
16
1783-1788
2006
Homo sapiens
Sonneck, K.; Baumgartner, C.; Rebuzzi, L.; Marth, K.; Chen, K.W.; Hauswirth, A.W.; Florian, S.; Vrtala, S.; Buehring, H.J.; Valenta, R.; Valent, P.
Recombinant allergens promote expression of aminopeptidase-N (CD13) on basophils in allergic patients
Int. J. Immunopathol. Pharmacol.
21
11-21
2008
Homo sapiens
Ito, K.; Nakajima, Y.; Onohara, Y.; Takeo, M.; Nakashima, K.; Matsubara, F.; Ito, T.; Yoshimoto, T.
Crystal structure of aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli and conformational change of methionine 260 involved in substrate recognition
J. Biol. Chem.
281
33664-33676
2006
Escherichia coli
Gomez, I.; Arenas, I.; Benitez, I.; Miranda-Rios, J.; Becerril, B.; Grande, R.; Almagro, J.C.; Bravo, A.; Soberon, M.
Specific epitopes of domains II and III of Bacillus thuringiensis Cry1Ab toxin involved in the sequential interaction with cadherin and aminopeptidase-N receptors in Manduca sexta
J. Biol. Chem.
281
34032-34039
2006
Manduca sexta
Miki, T.; Takegami, Y.; Okawa, K.; Muraguchi, T.; Noda, M.; Takahashi, C.
The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways
J. Biol. Chem.
282
12341-12352
2007
Homo sapiens
von Wallbrunn, A.; Waldeck, J.; Hoeltke, C.; Zuehlsdorf, M.; Mesters, R.; Heindel, W.; Schaefers, M.; Bremer, C.
In vivo optical imaging of CD13/APN-expression in tumor xenografts
J. Biomed. Opt.
13
011007
2008
Homo sapiens
Shang, L.; Maeda, T.; Xu, W.; Kishioka, S.
Evaluation of a novel aminopeptidase N inhibitor, in vitro, using two assay systems
J. Enzyme Inhib. Med. Chem.
23
198-205
2008
Cavia porcellus
Zhu, Y.; Huang, L.; Luo, X.; Sun, H.; Ran, D.; Zhang, K.; Zheng, M.; Zhou, K.; Liu, W.
Irradiation injury temporarily induces enhancement of APN/CD13 peptidase activity on aorta-gonads-mesonephros (AGM)-derived stromal cells
J. Huazhong Univ. Sci. Technol. Med. Sci.
27
145-148
2007
Mus musculus
Mina-Osorio, P.; Shapiro, L.H.; Ortega, E.
CD13 in cell adhesion: aminopeptidase N (CD13) mediates homotypic aggregation of monocytic cells
J. Leukoc. Biol.
79
719-730
2006
Homo sapiens
de Gortari, P.; Vargas, M.A.; Martinez, A.; Garcia-Vazquez, A.I.; Uribe, R.M.; Chavez-Gutierrez, L.; Magdaleno, V.; Boileau, G.; Charli, J.L.; Joseph-Bravo, P.
Stage-specific modulation of neprilysin and aminopeptidase N in the limbic system during kindling progression
J. Mol. Neurosci.
33
252-261
2007
Rattus norvegicus
Axen, A.; Andersson, H.; Lindeberg, G.; Roennholm, H.; Kortesmaa, J.; Demaegdt, H.; Vauquelin, G.; Karlen, A.; Hallberg, M.
Small potent ligands to the insulin-regulated aminopeptidase (IRAP)/AT(4) receptor
J. Pept. Sci.
13
434-444
2007
Homo sapiens
John, H.; John, S.; Forssmann, W.G.
Kinetic studies on aminopeptidase M-mediated degradation of human hemorphin LVV-H7 and its N-terminally truncated products
J. Pept. Sci.
14
797-803
2008
Sus scrofa
Gera, L.; Fortin, J.; Adam, A.; Stewart, J.M.; Marceau, F.
Discovery of a dual-function peptide that combines aminopeptidase N inhibition and kinin B1 receptor antagonism
J. Pharmacol. Exp. Ther.
317
300-308
2006
Oryctolagus cuniculus, Homo sapiens
Wulfaenger, J.; Niedling, S.; Riemann, D.; Seliger, B.
Aminopeptidase N (APN)/CD13-dependent CXCR4 downregulation is associated with diminished cell migration, proliferation and invasion
Mol. Membr. Biol.
25
72-82
2008
Homo sapiens
Rangel, R.; Sun, Y.; Guzman-Rojas, L.; Ozawa, M.G.; Sun, J.; Giordano, R.J.; Van Pelt, C.S.; Tinkey, P.T.; Behringer, R.R.; Sidman, R.L.; Arap, W.; Pasqualini, R.
Impaired angiogenesis in aminopeptidase N-null mice
Proc. Natl. Acad. Sci. USA
104
4588-4593
2007
Mus musculus
Kaur, R.; Agrawal, N.; Bhatnagar, R.
Purification and characterization of aminopeptidase N from Spodoptera litura expressed in Sf21 insect cells
Protein Expr. Purif.
54
267-274
2007
Spodoptera litura
Nocek, B.; Mulligan, R.; Bargassa, M.; Collart, F.; Joachimiak, A.
Crystal structure of aminopeptidase N from human pathogen Neisseria meningitidis
Proteins Struct. Funct. Bioinform.
70
273-279
2007
Neisseria meningitidis (Q9JYV4), Neisseria meningitidis
Zaytsev, A.V.; Anderson, R.J.; Bedernjak, A.; Groundwater, P.W.; Huang, Y.; Perry, J.D.; Orenga, S.; Roger-Dalbert, C.; James, A.
Synthesis and testing of chromogenic phenoxazinone substrates for beta-alanyl aminopeptidase
Org. Biomol. Chem.
6
682-692
2008
Pseudomonas aeruginosa, Pseudomonas aeruginosa NCTC 10662
Yang, L.E.; Sandberg, M.B.; Can, A.D.; Pihakaski-Maunsbach, K.; McDonough, A.A.
Effects of dietary salt on renal Na+ transporter subcellular distribution, abundance, and phosphorylation status
Am. J. Physiol. Renal Physiol.
295
F1003-F1016
2008
Rattus norvegicus
Uehara, N.; Fujita, M.; Shimizu, T.
Colorimetric assay of aminopeptidase N activity based on inhibition of the disassembly of gold nano-composites conjugated with a thermo-responsive copolymer
Anal. Sci.
25
267-273
2009
Homo sapiens
Li, S.H.; Li, G.; Huang, H.M.; Xiong, F.; Liu, C.M.; Tu, G.G.
The synthesis and preliminary activity assay in vitro of peptide-like derivatives as APN inhibitors
Arch. Pharm. Res.
31
1231-1239
2008
Sus scrofa
Shim, J.S.; Park, H.M.; Lee, J.; Kwon, H.J.
Global and focused transcriptional profiling of small molecule aminopeptidase N inhibitor reveals its mechanism of angiogenesis inhibition
Biochem. Biophys. Res. Commun.
371
99-103
2008
Homo sapiens
Zhang, R.; Hua, G.; Andacht, T.M.; Adang, M.J.
A 106-kDa aminopeptidase is a putative receptor for Bacillus thuringiensis Cry11Ba toxin in the mosquito Anopheles gambiae
Biochemistry
47
11263-11272
2008
Anopheles gambiae (C5H690), Anopheles gambiae, Anopheles gambiae CDC G3 (C5H690)
Addlagatta, A.; Gay, L.; Matthews, B.W.
Structural basis for the unusual specificity of Escherichia coli aminopeptidase N
Biochemistry
47
5303-5311
2008
Escherichia coli (P04825), Escherichia coli
Grzywa, R.; Oleksyszyn, J.
First synthesis of alpha-aminoalkyl-(N-substituted)thiocarbamoyl-phosphinates: inhibitors of aminopeptidase N (APN/CD13) with the new zinc-binding group
Bioorg. Med. Chem. Lett.
18
3734-3736
2008
Sus scrofa
Wang, Q.; Chen, M.; Zhu, H.; Zhang, J.; Fang, H.; Wang, B.; Xu, W.
Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors
Bioorg. Med. Chem.
16
5473-5481
2008
Sus scrofa
Tu, G.; Li, S.; Huang, H.; Li, G.; Xiong, F.; Mai, X.; Zhu, H.; Kuang, B.; Xu, W.F.
Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold
Bioorg. Med. Chem.
16
6663-6668
2008
Sus scrofa
Shang, L.; Wang, Q.; Fang, H.; Mu, J.; Wang, X.; Yuan, Y.; Wang, B.; Xu, W.
Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN)
Bioorg. Med. Chem.
16
9984-9990
2008
Sus scrofa
Shang, L.; Fang, H.; Zhu, H.; Wang, X.; Wang, Q.; Mu, J.; Wang, B.; Kishioka, S.; Xu, W.
Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors
Bioorg. Med. Chem.
17
2775-2784
2009
Homo sapiens
Li, X.; Wang, J.; Li, J.; Wu, J.; Li, Y.; Zhu, H.; Fan, R.; Xu, W.
Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I)
Bioorg. Med. Chem.
17
3053-3060
2009
Sus scrofa
Li, X.; Wang, Y.; Wu, J.; Li, Y.; Wang, Q.; Xu, W.
Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part II)
Bioorg. Med. Chem.
17
3061-3071
2009
Sus scrofa
Mawrin, C.; Wolke, C.; Haase, D.; Krueger, S.; Firsching, R.; Keilhoff, G.; Paulus, W.; Gutmann, D.H.; Lal, A.; Lendeckel, U.
Reduced activity of CD13/aminopeptidase N (APN) in aggressive meningiomas is associated with increased levels of SPARC
Brain Pathol.
20
200-210
2009
Homo sapiens
Timofeeva, N.M.; Egorova, V.V.; Nikitina, A.A.; Dmitrieva, J.V.
Delayed effects of the terms of separation of rat pups from lactating females and low-protein diet on enzyme activity in digestive and non-digestive organs
Bull. Exp. Biol. Med.
145
676-679
2008
Rattus norvegicus
Morikawa, T.; Xie, H.; Wang, T.; Matsuda, H.; Yoshikawa, M.
Acylated flavonol bisdesmosides, sinocrassosides A3-A7 and B3, with aminopeptidase N inhibitory activity from Sinocrassula indica
Chem. Biodivers.
6
411-420
2009
Homo sapiens
Morikawa, T.; Xie, H.; Wang, T.; Matsuda, H.; Yoshikawa, M.
Bioactive constituents from Chinese natural medicines. XXXII. aminopeptidase N and aldose reductase inhibitors from Sinocrassula indica: structures of sinocrassosides B4, B5, C1, and D1-D3
Chem. Pharm. Bull.
56
1438-1444
2008
Homo sapiens
Morikawa, T.; Funakoshi, K.; Ninomiya, K.; Yasuda, D.; Miyagawa, K.; Matsuda, H.; Yoshikawa, M.
Medicinal foodstuffs. XXXIV. Structures of new prenylchalcones and prenylflavanones with TNF-alpha and aminopeptidase N inhibitory activities from Boesenbergia rotunda
Chem. Pharm. Bull.
56
956-962
2008
Homo sapiens
Holdt, B.; Peters, E.; Nagel, H.R.; Steiner, M.
An automated assay of urinary alanine aminopeptidase activity
Clin. Chem. Lab. Med.
46
537-540
2008
Homo sapiens
Ansorge, S.; Bank, U.; Heimburg, A.; Helmuth, M.; Koch, G.; Tadje, J.; Lendeckel, U.; Wolke, C.; Neubert, K.; Faust, J.; Fuchs, P.; Reinhold, D.; Thielitz, A.; Taeger, M.
Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions
Clin. Chem. Lab. Med.
47
253-261
2009
Homo sapiens
Kawai, M.; Araragi, K.; Shimizu, Y.; Hara, Y.
Identification of placental leucine aminopeptidase and triton-slowed aminopeptidase N in serum of pregnant women
Clin. Chim. Acta
400
37-41
2009
Homo sapiens
Stankovic, M.; Vlahovic, P.; Avramovic, V.; Todorovic, M.
Distribution of dipeptidyl peptidase IV in patients with chronic tonsillitis
Clin. Vaccine Immunol.
15
794-798
2008
Homo sapiens
Zhang, X.; Xu, W.
Aminopeptidase N (APN/CD13) as a target for anti-cancer agent design
Curr. Med. Chem.
15
2850-2865
2008
Homo sapiens
Valaitis, A.P.
Bacillus thuringiensis pore-forming toxins trigger massive shedding of GPI-anchored aminopeptidase N from gypsy moth midgut epithelial cells
Insect Biochem. Mol. Biol.
38
611-618
2008
Lymantria dispar
Gabrilovac, J.; Breljak, D.; Cupic, B.
Regulation of aminopeptidase N (EC 3.4.11.2; APN; CD13) on the HL-60 cell line by TGF-beta1
Int. Immunopharmacol.
8
613-623
2008
Homo sapiens
Cai, J.; Kehoe, O.; Smith, G.M.; Hykin, P.; Boulton, M.E.
The angiopoietin/Tie-2 system regulates pericyte survival and recruitment in diabetic retinopathy
Invest. Ophthalmol. Vis. Sci.
49
2163-2171
2008
Homo sapiens
Takano, T.; Katada, Y.; Moritoh, S.; Ogasawara, M.; Satoh, K.; Satoh, R.; Tanabe, M.; Hohdatsu, T.
Analysis of the mechanism of antibody-dependent enhancement of feline infectious peritonitis virus infection: aminopeptidase N is not important and a process of acidification of the endosome is necessary
J. Gen. Virol.
89
1025-1029
2008
Felis catus
Lukaszuk, A.; Demaegdt, H.; Szemenyei, E.; Toth, G.; Tymecka, D.; Misicka, A.; Karoyan, P.; Vanderheyden, P.; Vauquelin, G.; Tourwe, D.
Beta-homo-amino acid scan of angiotensin IV
J. Med. Chem.
51
2291-2296
2008
Homo sapiens
Kuehlmann, U.C.; Chwieralski, C.E.; van den Brule, S.; Roecken, C.; Reinhold, D.; Welte, T.; Buehling, F.
Modulation of cytokine production and silica-induced lung fibrosis by inhibitors of aminopeptidase N and of dipeptidyl peptidase-IV-related proteases
Life Sci.
84
1-11
2009
Homo sapiens
Li, S.H.; Li, G.; Huang, H.M.; Xiong, F.; Mai, X.; Kuang, B.H.; Liu, C.M.; Tu, G.G.
Synthesis of 1,3,4-thiadiazole derivatives as aminopeptidase N inhibitors
Pharmazie
64
67-70
2009
Homo sapiens
Teranishi, J.; Ishiguro, H.; Hoshino, K.; Noguchi, K.; Kubota, Y.; Uemura, H.
Evaluation of role of angiotensin III and aminopeptidases in prostate cancer cells
Prostate
68
1666-1673
2008
Homo sapiens
Mina-Osorio, P.
The moonlighting enzyme CD13: old and new functions to target
Trends Mol. Med.
14
361-371
2008
Homo sapiens
Bhosale, M.; Pande, S.; Kumar, A.; Kairamkonda, S.; Nandi, D.
Characterization of two M17 family members in Escherichia coli, Peptidase A and Peptidase B
Biochem. Biophys. Res. Commun.
395
76-81
2010
Escherichia coli
Grzywa, R.; Oleksyszyn, J.; Salvesen, G.S.; Drag, M.
Identification of very potent inhibitor of human aminopeptidase N (CD13)
Bioorg. Med. Chem. Lett.
20
2497-2499
2010
Homo sapiens, Rattus norvegicus, Sus scrofa
Yang, K.; Wang, Q.; Su, L.; Fang, H.; Wang, X.; Gong, J.; Wang, B.; Xu, W.
Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors
Bioorg. Med. Chem.
17
3810-3817
2009
Sus scrofa
Liu, Y.; Shang, L.; Fang, H.; Zhu, H.; Mu, J.; Wang, Q.; Wang, X.; Yuan, Y.; Xu, W.
Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13
Bioorg. Med. Chem.
17
7398-7404
2009
Sus scrofa
Grzywa, R.; Sokol, A.M.; Sienczyk, M.; Radziszewicz, M.; Kosciolek, B.; Carty, M.P.; Oleksyszyn, J.
New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13
Bioorg. Med. Chem.
18
2930-2936
2010
Sus scrofa
Inagaki, Y.; Tang, W.; Zhang, L.; Du, G.; Xu, W.; Kokudo, N.
Novel aminopeptidase N (APN/CD13) inhibitor 24F can suppress invasion of hepatocellular carcinoma cells as well as angiogenesis
Biosci. Trends
4
56-60
2010
Homo sapiens
Hausheer, F.H.; Parker, A.R.; Petluru, P.N.; Jair, K.W.; Chen, S.; Huang, Q.; Chen, X.; Ayala, P.Y.; Shanmugarajah, D.; Kochat, H.
Mechanistic study of BNP7787-mediated cisplatin nephroprotection: modulation of human aminopeptidase N
Cancer Chemother. Pharmacol.
67
381-391
2011
Homo sapiens
Saxena, A.; Rai, A.; Raina, V.; Seth, T.; Mitra, D.K.
Expression of CD13/aminopeptidase N in precursor B-cell leukemia: role in growth regulation of B cells
Cancer Immunol. Immunother.
59
125-135
2010
Homo sapiens
Cui, S.X.; Qu, X.J.; Gao, Z.H.; Zhang, Y.S.; Zhang, X.F.; Zhao, C.R.; Xu, W.F.; Li, Q.B.; Han, J.X.
Targeting aminopeptidase N (APN/CD13) with cyclic-imide peptidomimetics derivative CIP-13F inhibits the growth of human ovarian carcinoma cells
Cancer Lett.
292
153-162
2010
Homo sapiens
Li, Q.; Fang, H.; Wang, X.; Xu, W.
Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Structure-based design, chemistry and activity evaluation. II
Eur. J. Med. Chem.
45
1618-1626
2010
Sus scrofa
Padia, S.H.; Howell, N.L.; Kemp, B.A.; Fournie-Zaluski, M.C.; Roques, B.P.; Carey, R.M.
Intrarenal aminopeptidase N inhibition restores defective angiotensin II type 2-mediated natriuresis in spontaneously hypertensive rats
Hypertension
55
474-480
2010
Rattus norvegicus
Chen, J.; Aimanova, K.G.; Pan, S.; Gill, S.S.
Identification and characterization of Aedes aegypti aminopeptidase N as a putative receptor of Bacillus thuringiensis Cry11A toxin
Insect Biochem. Mol. Biol.
39
688-696
2009
Aedes aegypti (Q16L33), Aedes aegypti
Liu, B.; Li, G.; Sui, X.; Yin, J.; Wang, H.; Ren, X.
Expression and functional analysis of porcine aminopeptidase N produced in prokaryotic expression system
J. Biotechnol.
141
91-96
2009
Sus scrofa
Nam, E.; Lee, C.
Contribution of the porcine aminopeptidase N (CD13) receptor density to porcine epidemic diarrhea virus infection
Vet. Microbiol.
144
41-50
2010
Sus scrofa
Tsirulnikov, K.; Abuladze, N.; Bragin, A.; Faull, K.; Cascio, D.; Damoiseaux, R.; Schibler, M.J.; Pushkin, A.
Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal
Toxicol. Appl. Pharmacol.
263
303-314
2012
Mus musculus
Weglarz-Tomczak, E.; Poreba, M.; Byzia, A.; Berlicki, L.; Nocek, B.; Mulligan, R.; Joachimiak, A.; Drag, M.; Mucha, A.
An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling
Biochimie
95
419-428
2013
Neisseria meningitidis
Krishnamoorthy, M.; Achary, A.
Exploration of Sitagliptin as a potential inhibitor for the M1 Alanine aminopeptidase enzyme in Plasmodium falciparum using computational docking
Bioinformation
9
293-298
2013
Plasmodium falciparum
Pillay, D.; Boulange, A.F.; Coustou, V.; Baltz, T.; Coetzer, T.H.
Recombinant expression and biochemical characterisation of two alanyl aminopeptidases of Trypanosoma congolense
Exp. Parasitol.
135
675-684
2013
Trypanosoma congolense (F9W8I6), Trypanosoma congolense (G0UZY5)
Bhosale, M.; Kumar, A.; Das, M.; Bhaskarla, C.; Agarwal, V.; Nandi, D.
Catalytic activity of Peptidase N is required for adaptation of Escherichia coli to nutritional downshift and high temperature stress
Microbiol. Res.
168
56-64
2013
Escherichia coli (P04825), Escherichia coli
Shibata, M.; Koike, M.; Kusumi, S.; Sato, N.; Uchiyama, Y.
A specific tripeptidyl substrate for tripeptidyl peptidase activity is effectively hydrolyzed by alanyl aminopeptidase/aminopeptidase N/CD13 in the rat kidney
Arch. Histol. Cytol.
76
1-8
2016
Rattus norvegicus (P15684), Rattus norvegicus Wistar (P15684)
-
Gong, Q.; Shi, W.; Li, L.; Ma, H.
Leucine aminopeptidase may contribute to the intrinsic resistance of cancer cells toward cisplatin as revealed by an ultrasensitive fluorescent probe
Chem. Sci.
7
788-792
2016
Homo sapiens (P28838)
Bizon, A.; Milnerowicz, H.
The effect of passive and active exposure to tobacco smoke on lipid profile parameters and the activity of certain membrane enzymes in the blood of women in the first trimester of pregnancy
Environ. Toxicol. Pharmacol.
53
74-80
2017
Homo sapiens (P15144), Homo sapiens
Weglarz-Tomczak, E.; Berlicki, L.; Pawelczak, M.; Nocek, B.; Joachimiak, A.; Mucha, A.
A structural insight into the P1S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases
Eur. J. Med. Chem.
117
187-196
2016
Homo sapiens (P15144), Neisseria meningitidis serogroup B (Q9JYV4), Neisseria meningitidis serogroup B MC58 (Q9JYV4)
Bedernjak, A.F.; Zaytsev, A.V.; Babolat, M.; Cellier, M.; James, A.L.; Orenga, S.; Perry, J.D.; Groundwater, P.W.; Anderson, R.J.
Synthesis and evaluation of novel 7- and 8-aminophenoxazinones for the detection of beta-alanine aminopeptidase activity and the reliable identification of Pseudomonas aeruginosa in clinical samples
J. Med. Chem.
59
4476-4487
2016
Pseudomonas aeruginosa
Linz, L.B.; Liu, S.; Chougule, N.P.; Bonning, B.C.
In vitro evidence supports membrane alanyl aminopeptidase N as a receptor for a plant virus in the pea aphid vector
J. Virol.
89
11203-11212
2015
Acyrthosiphon pisum (Q1W3E8), Acyrthosiphon pisum
Quesada, A.; Segarra, A.B.; Montoro-Molina, S.; de Gracia, M.D.; Osuna, A.; O'Valle, F.; Gomez-Guzman, M.; Vargas, F.; Wangensteen, R.
Glutamyl aminopeptidase in microvesicular and exosomal fractions of urine is related with renal dysfunction in cisplatin-treated rats
PLoS ONE
12
e0175462
2017
Rattus norvegicus (P15684), Rattus norvegicus Wistar (P15684)
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