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Disease on EC 3.4.11.2 - membrane alanyl aminopeptidase

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DISEASE
TITLE OF PUBLICATION
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Acidosis
Altered intestinal and renal brush border amino-oligopeptidase structure in diabetes and metabolic acidosis: normal and biobreed (BB) rats.
Acne Vulgaris
Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation.
Acquired Immunodeficiency Syndrome
Prenatal diagnosis of cystic fibrosis by assay of amniotic fluid microvillar enzymes.
Subtype C gp140 Vaccine Boosts Immune Responses Primed by the South African AIDS Vaccine Initiative DNA-C2 and MVA-C HIV Vaccines after More than a 2-Year Gap.
Acute Kidney Injury
Differentiation of acute renal failure and chronic renal failure by 2-dimensional analysis of urinary dipeptidase versus serum creatinine.
Nitric oxide inhibits the shedding of the glycosylphosphatidylinositol-anchored dipeptidase from porcine renal proximal tubules.
Specimen collection time for enzyme analysis in urine.
Urine proteomic analysis reveals alterations in heme/hemoglobin and aminopeptidase metabolism during Lonomia obliqua venom-induced acute kidney injury.
[Experimental studies on the elevation of urinary enzyme activities and its pathogenesis in acute renal failure]
Adenocarcinoma
ACO2 and ANPEP as novel prognostic markers for gallbladder squamous cell/adenosquamous carcinomas and adenocarcinomas.
Enzyme activity and distribution in rat prostatic adenocarcinoma.
Expression and clinical significance of aminopeptidase N/CD13 in non-small cell lung cancer.
Intestinal differentiation and p53 gene alterations in Barrett's esophagus and esophageal adenocarcinoma.
Kininase I, kininase II and aminopeptidase levels in patients with gastrointestinal tumors.
Adenocarcinoma of Lung
Expression and clinical significance of aminopeptidase N/CD13 in non-small cell lung cancer.
Adenocarcinoma, Follicular
Decrease in Dipeptidyl Peptidase IV Activity is Linked to the Efficacy of Differentiating Compounds in Follicular Thyroid Carcinoma Cell Lines.
Adenoma
Brush border hydrolases in normal and neoplastic colonic epithelium.
Adenoma, Bile Duct
[Usefulness of carbohydrate antigen 19-9 (CA19-9) for the diagnosis of cholangioma. As a role of screening patients with the elevation of serum alkaline phosphatase, leucine aminopeptidase and/or gamma-glutamyl transpeptidase]
Adenomatous Polyposis Coli
Advances in the study of Lynch syndrome in China.
Adenomyosis
Expression of aminopeptidase N and neutral endopeptidase on the endometrial stromal cells in endometriosis and adenomyosis.
Albuminuria
The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting proteins regulate upstream pathways in podocyte diseases.
Urinary aminopeptidase activities as early and predictive biomarkers of renal dysfunction in cisplatin-treated rats.
Alveolitis, Extrinsic Allergic
The significance of cathepsins, thrombin and aminopeptidase in diffuse interstitial lung diseases.
Alzheimer Disease
Alanyl-aminopeptidase activity decrease in cerebrospinal fluid of Alzheimer patients.
Comparison of aminopeptidase, dipeptidyl aminopeptidase and tripeptidyl aminopeptidase activities in brain tissue from normal and Alzheimer's disease cases.
Comparison of major cortical aminopeptidase activity in normal brain and brain from patients with Alzheimer's disease.
Demonstration of puromycin-sensitive alanyl aminopeptidase in Alzheimer disease brain.
Insights into the molecular interactions between aminopeptidase and amyloid beta peptide using molecular modeling techniques.
Plasma renin-angiotensin system-regulating aminopeptidase activities are modified in early stage Alzheimer's disease and show gender differences but are not related to apolipoprotein E genotype.
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.
Reduction of plasma glutamyl aminopeptidase activity in sporadic Alzheimer's disease.
Anaphylaxis
Characterization of slow reacting substances (SRSs) of rat basophilic leukemia (RBL-1) cells: effect of cysteine on SRS profile.
[Determination of the dipeptidase and tripeptidase activity in anaphylactoid shock.]
Arthritis
Expression of aminopeptidase N/CD13 in tumour-infiltrating lymphocytes from human renal cell carcinoma.
Neutral aminopeptidase and dipeptidyl peptidase IV in the development of collagen II-induced arthritis.
Review: Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Arthritis, Rheumatoid
Basic aminopeptidase activity is an emerging biomarker in collagen-induced rheumatoid arthritis.
CD13/aminopeptidase N in collagen vascular diseases.
Diagnostic value of brush border enzymes of the proximal renal tubules in rheumatoid arthritis.
Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes.
Expression and function of aminopeptidase N/CD13 produced by fibroblast-like synoviocytes in rheumatoid arthritis: role of CD13 in chemotaxis of cytokine-activated T cells independent of enzymatic activity.
Localization, Shedding, Regulation and Function of Aminopeptidase N/CD13 on Fibroblast like Synoviocytes.
Review: Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Asthenozoospermia
Enkephalin-degrading enzymes in normal and subfertile human semen.
Asthma
Comparative Study of SARS-CoV-2, SARS-CoV-1, MERS-CoV, HCoV-229E and Influenza Host Gene Expression in Asthma: Importance of Sex, Disease Severity, and Epithelial Heterogeneity.
Dexamethasone accelerates catabolism of leukotriene C4 in bronchial epithelial cells.
Streptococcus pneumoniae aminopeptidase N regulates dendritic cells that attenuates type-2 airway inflammation in murine allergic asthma.
Astrocytoma
Cell surface antigens of human malignant melanoma: definition of six antigenic systems with mouse monoclonal antibodies.
Differential Effects of Doxazosin on Renin-Angiotensin-System-Regulating Aminopeptidase Activities in Neuroblastoma and Glioma Tumoral Cells.
Atherosclerosis
Effect of BuShen JiangZhi Recipe on Atherosclerosis in ApoE-/- Mice by Regulating the Expression of Anpep via mmu_circRNA_22187.
Atrial Fibrillation
Long-range regulatory interactions at the 4q25 atrial fibrillation risk locus involve PITX2c and ENPEP.
Autoimmune Diseases
Modulation of Natural HLA-B*27:05 Ligandome by Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 2 (ERAP2).
Review: Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
The Role of Dipeptidyl Peptidase 4 as a Therapeutic Target and Serum Biomarker in Inflammatory Bowel Disease: A Systematic Review.
The role of ERAP1 in autoinflammation and autoimmunity.
Transcriptional regulation of cytosol and membrane alanyl-aminopeptidase in human T cell subsets.
beta-ala-his dipeptidase deficiency
Carnosinase, diabetes mellitus and the potential relevance of carnosinase deficiency.
Biliary Atresia
Expression of aminopeptidase N in bile canaliculi: a predictor of clinical outcome in biliary atresia and a potential tool to implicate the mechanism of biliary atresia.
Biliary Tract Diseases
[Comparative studies of the activity of leucine aminopeptidase and glycyl aminopeptidase in liver and biliary tract diseases]
[Comparative study of leucyl aminopeptidase and glycyl aminopeptidase activity in liver and biliary tract diseases. I. Behavior of both enzymes in serum and liver tissue]
Blister
Supported Planar Mammalian Membranes as Models of in vivo Cell Surface Architectures.
[Histotopography of aminopeptidase in pemphigus vulgaris; with a contribution to the pathogenesis of acantholytic blister formation.]
Bowen's Disease
Aminopeptidase M and dipeptidyl peptidase IV activity in epithelial skin tumors: a histochemical study.
Brain Ischemia
Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia.
Brain Neoplasms
Regulation of aminopeptidase A in human brain tumor vasculature: evidence for a role of transforming growth factor-beta.
The antiangiogenic efficacy of NGR-modified PEG-DSPE micelles containing paclitaxel (NGR-M-PTX) for the treatment of glioma in rats.
[Cathepsin H activity in the human brain and human brain neoplasms]
Breast Neoplasms
A PAK5-DNPEP-USP4 axis dictates breast cancer growth and metastasis.
Aminopeptidase activities in breast cancer tissue.
AZGP1 and SPDEF mRNA expression differentiates breast carcinoma from ovarian serous carcinoma.
Circulating renin-angiotensin system-regulating specific aminopeptidase activities in pre- and post- menopausal women with breast cancer treated or not with neoadyuvant chemotherapy. A two years follow up study.
COVID-19 infection can cause chemotherapy resistance development in patients with breast cancer and tamoxifen may cause susceptibility to COVID-19 infection.
Evaluation of an Integrin ?v?3 and Aminopeptidase N Dual-Receptor Targeting Tracer for Breast Cancer Imaging.
Hypothalamus-pituitary-thyroid axis disruption in rats with breast cancer is related to an altered endogenous oxytocin/insulin-regulated aminopeptidase (IRAP) system.
Insulin-regulated aminopeptidase/placental leucil Aminopeptidase (IRAP/P-lAP) and angiotensin IV-forming activities are modified in serum of rats with breast cancer induced by N-methyl-nitrosourea.
Mammary renin-angiotensin system-regulating aminopeptidase activities are modified in rats with breast cancer.
miR-125b Acts as a Tumor Suppressor in Breast Tumorigenesis via Its Novel Direct Targets ENPEP, CK2-?, CCNJ, and MEGF9.
Normolipidic dietary fat modifies circulating Renin-Angiotensin system-regulating aminopeptidase activities in rat with breast cancer.
Prognostic value of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and aminopeptidase N/CD13 in breast cancer patients.
Quantification of membrane and membrane-bound proteins in normal and malignant breast cancer cells isolated from the same patient with primary breast carcinoma.
Renin angiotensin system-regulating aminopeptidase activities in serum of pre- and postmenopausal women with breast cancer.
Renin-Angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea.
Serum enkephalin-degrading aminopeptidase activity in N-methyl nitrosourea-induced rat breast cancer.
Specific enkephalin-degrading aminopeptidase activity in the HPT and HPO axes of rats with breast cancer induced by N-methyl nitrosourea.
Bronchitis
Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus.
The role of feline aminopeptidase N as a receptor for infectious bronchitis virus. Brief review.
Brucellosis
Purification and characterization of an immunogenic aminopeptidase of Brucella melitensis.
Candidiasis
Improved immunodiagnosis of human candidiasis by an enzyme-linked immunosorbent assay using a Candida albicans 52-kilodalton metallopeptidase.
Candidiasis, Oral
The membrane-bound intestinal enzymes of waxwings and thrushes: adaptive and functional implications of patterns of enzyme activity.
Carcinogenesis
DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway.
Enhanced anticancer activity of 5-FU in combination with Bestatin: Evidence in human tumor-derived cell lines and an H22 tumor-bearing mouse.
Expression and different polarity of aminopeptidase N in normal human colonic mucosa and colonic tumors.
Histochemical observations on aminopeptidase in the mouse skin in experimental carcinogenesis.
miR-125b Acts as a Tumor Suppressor in Breast Tumorigenesis via Its Novel Direct Targets ENPEP, CK2-?, CCNJ, and MEGF9.
Prostate cancer gene expression signature of patients with high body mass index.
Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy.
Carcinoma
13F-1, a novel 5-fluorouracil prodrug containing an Asn-Gly-Arg (NO2) COOCH3 tripeptide, inhibits human colonic carcinoma growth by targeting Aminopeptidase N (APN/CD13).
ACO2 and ANPEP as novel prognostic markers for gallbladder squamous cell/adenosquamous carcinomas and adenocarcinomas.
Addition of an aminopeptidase N-binding sequence to human endostatin improves inhibition of ovarian carcinoma growth.
Aminopeptidase M and dipeptidyl peptidase IV activity in epithelial skin tumors: a histochemical study.
AZGP1 and SPDEF mRNA expression differentiates breast carcinoma from ovarian serous carcinoma.
Cell cycle phases of two human lung tumor cell lines derived from squamous cell carcinoma and pulmonary metastasis of a rhabdomyosarcoma (HS 24 and HS 57) and N-acetylalanine aminopeptidase activity.
Cell surface antigens in renal tumour cells: detection by immunoluminescence and enzymatic analysis.
CIP-13F, a novel aminopeptidase N (APN/CD13) inhibitor, inhibits Lewis lung carcinoma growth and metastasis in mice.
Clinical significance of aminopeptidase N/CD13 expression in human pancreatic carcinoma.
Clinicopathological significance of aminopeptidase N/CD13 expression in human gastric carcinoma.
Effect of thyroid hormone-nitric oxide interaction on tumor growth, angiogenesis, and aminopeptidase activity in mice.
Enzyme activity and distribution in rat prostatic adenocarcinoma.
Expression of aminopeptidase N/CD13 in tumour-infiltrating lymphocytes from human renal cell carcinoma.
Expression of the COVID-19 receptor ACE2 in the human conjunctiva.
Histochemical study of aminopeptidase in metaplasia and carcinoma of the stomach.
Immunohistochemical expression of aminopeptidase N (CD13) in human lung squamous cell carcinomas, with special reference to Bestatin adjuvant therapy.
Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinoma.
Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells.
Inhibitory effects of ubenimex (bestatin) on the invasion of uterine cervical carcinoma cells and their production and activation of gelatinase A.
Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo.
LYP, a bestatin dimethylaminoethyl ester, inhibited cancer angiogenesis both in vitro and in vivo.
LYP, a novel bestatin derivative, inhibits cell growth and suppresses APN/CD13 activity in human ovarian carcinoma cells more potently than bestatin.
MicroRNA-125a attenuates the chemoresistance against ubenimex in non-small cell lung carcinoma via targeting the aminopeptidase N signaling pathway.
Monoclonal antibody raised against apoprotein of C-1027: effect on biochemical and biological activities of the holoantibiotic.
OF4949, new inhibitors of aminopeptidase B. I. Taxonomy, fermentation, isolation and characterization.
Stimulation of the expression and the enzyme activity of aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 on human renal cell carcinoma cells and renal tubular epithelial cells by T cell-derived cytokines, such as IL-4 and IL-13.
Targeting aminopeptidase N (APN/CD13) with cyclic-imide peptidomimetics derivative CIP-13F inhibits the growth of human ovarian carcinoma cells.
The pro-oxidant buthionine sulfoximine (BSO) reduces tumor growth of implanted Lewis lung carcinoma in mice associated with increased protein carbonyl, tubulin abundance, and aminopeptidase activity.
The role of aminopeptidases in inflammatory and neoplastic tissues.
Villin, intestinal brush border hydrolases and keratin polypeptides in intestinal metaplasia and gastric cancer; an immunohistologic study emphasizing the different degrees of intestinal and gastric differentiation in signet ring cell carcinomas.
[Aminopeptidase activity in gastric carcinoma.]
[Biological study of aminopeptidase in chemically induced carcinoma]
[Do immunologic markers facilitate differentiation between histologic types of stomach cancer?]
[Histochemical determination of aminopeptidase in normal skin, psoriasis, dermatitis, basaloma, spinous cell carcinoma and molluscum sebaceum.]
[Placental type of aminopeptidase N from renal cell carcinoma: frequency, and biochemical and immunological studies]
[Urinary excretion of glycine.prolile dipeptidile aminopeptidase, N-acetyl-beta-D-glucosaminidase, alanine aminopeptidase and low molecular protein in patients with renal cell carcinoma]
Carcinoma, Basal Cell
Aminopeptidase M and dipeptidyl peptidase IV activity in epithelial skin tumors: a histochemical study.
Carcinoma, Hepatocellular
Canalicular immunostaining of aminopeptidase N (CD13) as a diagnostic marker for hepatocellular carcinoma.
CD13 Induces Autophagy to Promote Hepatocellular Carcinoma Cell Chemoresistance Through the P38/Hsp27/CREB/ATG7 Pathway.
Designed three-in-one peptides with anchoring, antifouling and recognizing capabilities for highly sensitive and low fouling electrochemical sensing in complex biological media.
Ectopeptidases are differentially expressed in hepatocellular carcinomas.
Glycylproline dipeptidyl aminopeptidase isoenzyme in diagnosis of primary hepatocellular carcinoma.
In situ imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe.
In vivo assessment of aminopeptidase N (APN/CD13) specificity of different 68Ga-labelled NGR derivatives using PET/MRI imaging.
Inhibition of leukotriene D4 catabolism by D-penicillamine.
Link of a ubiquitous human coronavirus to dromedary camels.
Novel aminopeptidase N (APN/CD13) inhibitor 24F can suppress invasion of hepatocellular carcinoma cells as well as angiogenesis.
Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells.
The value of serum GPDA-F for the diagnosis of primary hepatocellular carcinoma.
[Clinical Significance of Serum GPDA-F Determined by Immunoelectrophoresis in Diagnosis of Hepatocellular Carcinoma.]
Carcinoma, Lewis Lung
CIP-13F, a novel aminopeptidase N (APN/CD13) inhibitor, inhibits Lewis lung carcinoma growth and metastasis in mice.
The pro-oxidant buthionine sulfoximine (BSO) reduces tumor growth of implanted Lewis lung carcinoma in mice associated with increased protein carbonyl, tubulin abundance, and aminopeptidase activity.
Carcinoma, Non-Small-Cell Lung
Circulating aminopeptidase N/CD13 is an independent prognostic factor in patients with non-small cell lung cancer.
Clinical significance of aminopeptidase N in non-small cell lung cancer.
Expression and clinical significance of aminopeptidase N/CD13 in non-small cell lung cancer.
MicroRNA-125a attenuates the chemoresistance against ubenimex in non-small cell lung carcinoma via targeting the aminopeptidase N signaling pathway.
Neutral endopeptidase/CD10 and aminopeptidase N/CD13 gene expression as a prognostic factor in non-small cell lung cancer.
Carcinoma, Renal Cell
A classification of tumor development based on an analysis of enzymes in tissue sections of hypernephroid carcinoma in man.
Cell surface antigens in renal tumour cells: detection by immunoluminescence and enzymatic analysis.
Expression of aminopeptidase N/CD13 in tumour-infiltrating lymphocytes from human renal cell carcinoma.
Reduced Activity of CD13/Aminopeptidase N (APN) in Aggressive Meningiomas Is Associated with Increased Levels of SPARC.
Regulation of the expression of aminopeptidase A, aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 in renal carcinoma cells and renal tubular epithelial cells by cytokines and cAMP-increasing mediators.
Stimulation of the expression and the enzyme activity of aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 on human renal cell carcinoma cells and renal tubular epithelial cells by T cell-derived cytokines, such as IL-4 and IL-13.
[Placental type of aminopeptidase N from renal cell carcinoma: frequency, and biochemical and immunological studies]
[Urinary excretion of glycine.prolile dipeptidile aminopeptidase, N-acetyl-beta-D-glucosaminidase, alanine aminopeptidase and low molecular protein in patients with renal cell carcinoma]
Carcinoma, Squamous Cell
Aminopeptidase M and dipeptidyl peptidase IV activity in epithelial skin tumors: a histochemical study.
Cell cycle phases of two human lung tumor cell lines derived from squamous cell carcinoma and pulmonary metastasis of a rhabdomyosarcoma (HS 24 and HS 57) and N-acetylalanine aminopeptidase activity.
Expression and clinical significance of aminopeptidase N/CD13 in non-small cell lung cancer.
Expression of the COVID-19 receptor ACE2 in the human conjunctiva.
Immunohistochemical expression of aminopeptidase N (CD13) in human lung squamous cell carcinomas, with special reference to Bestatin adjuvant therapy.
Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinoma.
Cardiovascular Diseases
Role of central and peripheral aminopeptidase activities in the control of blood pressure: a working hypothesis.
Cataract
Increased lens dipeptidase activity in aging and cataract.
Celiac Disease
Evidence for a compensatory increase in synthesis of brush border enzymes in the jejunum of Irish Setters with gluten-sensitive enteropathy.
[Morphologic and histochemical study of the intestinal mucosa in celiac disease. Leucine aminopeptidase behavior in gluten intolerance]
Cholelithiasis
Biliary aminopeptidase-N and the cholesterol crystallisation defect in cholelithiasis.
Cholesterol crystallization-promoting activity of aminopeptidase-N isolated from the vesicular carrier of biliary lipids.
Cholera
Inhibitory effect of somatostatin on cholera toxin-induced diarrhea and glycoenzyme secretion in rat intestine.
Cholestasis
Plasma endopeptidase 24.11 (enkephalinase) activity is markedly increased in cholestatic liver disease.
[The activity of cholestatic enzymes in viral hepatitis B]
Cholestasis, Intrahepatic
Alanine aminopeptidase in serum: automated optimized assay, and effects of age, sex, smoking, and alcohol consumption in a selected population.
Cholesteatoma
Altered regulation of cell surface peptidases in human cholesteatoma.
Choriocarcinoma
Aminopeptidase inhibitor ubenimex (bestatin) inhibits the growth of human choriocarcinoma in nude mice through its direct cytostatic activity.
Expression of aminopeptidase N on human choriocarcinoma cells and cell growth suppression by the inhibition of aminopeptidase N activity.
Ikaros is expressed in human extravillous trophoblasts and involved in their migration and invasion.
Progesterone stimulates the expression of aminopeptidase A/angiotensinase in human choriocarcinoma cells.
SERUM AMINOPEPTIDASE IN PREGNANCY, HYDATIFORM MOLE, AND CHORIOCARCINOMA.
Studies of serum aminopeptidase in pregnancy, hydatidiform mole, and choriocarcinoma.
Chronic Periodontitis
Alanine aminopeptidase and dipeptidyl peptidase IV in saliva of chronic periodontitis patients.
Coccidiosis
Aminopeptidase N1 (EtAPN1), an M1 metalloprotease of the apicomplexan parasite Eimeria tenella, participates in parasite development.
Biochemical characterization of aminopeptidase N2 from Toxoplasma gondii.
Coinfection
Porcine epidemic diarrhea virus (PEDV) co-infection induced chlamydial persistence/stress does not require viral replication.
Colitis
Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-beta1 and ameliorates acute colitis in mice.
Morphological and biochemical alterations in the jejunum following iodoacetamide-induced colitis in rats.
Colitis, Ulcerative
Enzymatic and morphometric evidence for Crohn's disease as a diffuse lesion of the gastrointestinal tract.
Inflammation, adenoma and cancer: objective classification of colon biopsy specimens with gene expression signature.
Renal tubular damage: an extraintestinal manifestation of chronic inflammatory bowel disease.
Colonic Neoplasms
Aminopeptidase N is involved in cell motility and angiogenesis: its clinical significance in human colon cancer.
Cinnamic acid inhibits proliferation and modulates brush border membrane enzyme activities in Caco-2 cells.
Immunohistological evidence, obtained with monoclonal antibodies, of small intestinal brush border hydrolases in human colon cancers and foetal colons.
Synthesis, docking, cytotoxicity, and LTA4H inhibitory activity of new gingerol derivatives as potential colorectal cancer therapy.
Colorectal Neoplasms
Aminopeptidase N activity predicts 5-year survival in colorectal cancer patients.
Clinicopathological examination of dipeptidase 1 expression in colorectal cancer.
Dipeptidase 1 (DPEP1) is a marker for the transition from low-grade to high-grade intraepithelial neoplasia and an adverse prognostic factor in colorectal cancer.
Dipeptidase 1: a candidate tumor-specific molecular marker in colorectal carcinoma.
Distinguishing primary from secondary mucinous ovarian tumors: an algorithm using the novel marker DPEP1.
Effect of growth and sodium butyrate on brush border membrane-associated hydrolases in human colorectal cancer cell lines.
Intestinal brush-border-associated enzymes: co-ordinated expression in colorectal cancer.
Colorectal Neoplasms, Hereditary Nonpolyposis
Advances in the study of Lynch syndrome in China.
Common Cold
The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish.
Communicable Diseases
A randomized study comparing clinical efficacy and safety of thienamycin formamidine (MK0787)/renal dipeptidase inhibitor (MK0791) and cefazolin.
Congenital Abnormalities
Effect of dietary phospholipid levels on performance, enzyme activities and fatty acid composition of pikeperch (Sander lucioperca) larvae
Coronavirus Infections
Phage displayed peptides recognizing porcine aminopeptidase N inhibit transmissible gastroenteritis coronavirus infection in vitro.
Role of Porcine Aminopeptidase N and Sialic Acids in Porcine Coronavirus Infections in Primary Porcine Enterocytes.
The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish.
COVID-19
Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism.
Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants.
Renin-angiotensin system inhibition and risk of infection and mortality in COVID-19: a systematic review and meta-analysis.
Crohn Disease
Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes.
Enzymatic and morphometric evidence for Crohn's disease as a diffuse lesion of the gastrointestinal tract.
Inflammation, adenoma and cancer: objective classification of colon biopsy specimens with gene expression signature.
Renal tubular damage: an extraintestinal manifestation of chronic inflammatory bowel disease.
Cross Infection
Pseudomonas aeruginosa Leucine Aminopeptidase Influences Early Biofilm Composition and Structure via Vesicle-Associated Antibiofilm Activity.
Cryptogenic Organizing Pneumonia
The significance of cathepsins, thrombin and aminopeptidase in diffuse interstitial lung diseases.
Cryptorchidism
Increase of methionine aminopeptidase activity in hyperplastic Leydig cells of rat cryptorchid testis: a histochemical study.
Increase of methionine-aminopeptidase activity in hyperplastic Leydig cells of rat cryptorchid testis.
Cystic Fibrosis
Amniotic fluid microvillar enzyme activities in the early detection of fetal abnormalities.
Prenatal diagnosis in 200 pregnancies with a 1-in-4 risk of cystic fibrosis.
Prenatal diagnosis of cystic fibrosis by assay of amniotic fluid microvillar enzymes.
Pseudomonas aeruginosa Leucine Aminopeptidase Influences Early Biofilm Composition and Structure via Vesicle-Associated Antibiofilm Activity.
Synthesis and testing of chromogenic phenoxazinone substrates for beta-alanyl aminopeptidase.
Transimmortalized mouse intestinal cells (m-ICc12) that maintain a crypt phenotype.
[Activity of enzymes in amniotic fluid in prenatal diagnosis of cystic fibrosis]
[Prenatal diagnosis of mucoviscidosis: biochemical technics and studies of affected fetuses]
Cysts
Aminopeptidase activity in the brains of mice with chronic Toxoplasma gondii infections.
Chymase-like angiotensin II-generating activity in end-stage human autosomal dominant polycystic kidney disease.
Cloning and characterisation of a Heterodera glycines aminopeptidase cDNA.
Differential effects of DNA tumor virus genes on the expression profiles, differentiation, and morphogenetic reprogramming potential of epithelial cells.
The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts.
Cytomegalovirus Infections
CD13 (human aminopeptidase N) mediates human cytomegalovirus infection.
Dehydration
Effects of dehydration on renal aminopeptidase activities in adult male and female rats.
Dengue
Aminopeptidase secreted by Chromobacterium sp. Panama inhibits dengue virus infection by degrading the E protein.
Dental Caries
Aminopeptidase activity in carious dentin.
Effect of a Ca(OH)2 solution and a chlorhexidine based detergent on the microbial activity of human carious teeth.
Dermatitis
[Histochemical determination of aminopeptidase in normal skin, psoriasis, dermatitis, basaloma, spinous cell carcinoma and molluscum sebaceum.]
Diabetes Complications
Protease profiling of different biofluids in type 1 diabetes mellitus.
Diabetes Insipidus
Osmoregulation, the secretion of arginine vasopressin and its metabolism during pregnancy.
Diabetes Mellitus
CLINICAL CHARACTERISTICS OF PATIENTS WITH TYPE 2 DIABETES MELLITUS CONTINUED ON ORAL ANTIDIABETES MEDICATIONS IN THE HOSPITAL.
Comparison of N-acetyl-beta-D-glucosaminidase and alanine aminopeptidase activities for evaluation of microangiopathy in diabetes mellitus.
Prospective evaluation of aminopeptidase activities in plasma and peripheral organs of streptozotocin-induced diabetic rats.
Studies on proteolytic activities in heart muscle of diabetic rats.
[Clinical significance of urinary alanine aminopeptidase in diabetes mellitus]
Diabetes Mellitus, Experimental
Urinary excretion of alanine aminopeptidase and total proteinuria in experimental diabetes mellitus before and after islet transplantation.
Diabetes Mellitus, Type 1
Protease profiling of different biofluids in type 1 diabetes mellitus.
The putative role of proteolytic pathways in the pathogenesis of Type 1 diabetes mellitus: The 'autophagy' hypothesis.
[Urinary enzymes in insulin-dependent diabetes mellitus]
Diabetes Mellitus, Type 2
Berry and Citrus Phenolic Compounds Inhibit Dipeptidyl Peptidase IV: Implications in Diabetes Management.
CLINICAL CHARACTERISTICS OF PATIENTS WITH TYPE 2 DIABETES MELLITUS CONTINUED ON ORAL ANTIDIABETES MEDICATIONS IN THE HOSPITAL.
Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes.
Recent progress in natural products as DPP-4 inhibitors.
Reversal of increased lymphocyte PC-1 activity in patients with type 2 diabetes treated with metformin.
The influence of a single nucleotide polymorphism within CNDP1 on susceptibility to diabetic nephropathy in Japanese women with type 2 diabetes.
Urinary Lysosomal Enzyme Activities and Albuminuria in Ghanaian Patients with Type 2 Diabetes Mellitus.
Diabetic Angiopathies
Comparison of N-acetyl-beta-D-glucosaminidase and alanine aminopeptidase activities for evaluation of microangiopathy in diabetes mellitus.
Diabetic Nephropathies
Association of CTG repeat polymorphism in carnosine dipeptidase 1 (CNDP1) gene with diabetic nephropathy in north Indians.
Diagnostic value of the aminopeptidase N, N-acetyl-beta-D-glucosaminidase and dipeptidylpeptidase IV in evaluating tubular dysfunction in patients with glomerulopathies.
The influence of a single nucleotide polymorphism within CNDP1 on susceptibility to diabetic nephropathy in Japanese women with type 2 diabetes.
Urinary Lysosomal Enzyme Activities and Albuminuria in Ghanaian Patients with Type 2 Diabetes Mellitus.
[Clinical evaluation of urinary alanine aminopeptidase in the patients with diabetes mellitus-comparison among AAP microalbumin and N-acetyl-beta-D-glucosaminidase]
[Clinical significance of urinary glycyl-prolyl dipeptidyl aminopeptidase in diabetic nephropathies]
[Urinary alanine aminopeptidase and lysozyme excretion in patients with diabetes]
[Urinary enzymes in insulin-dependent diabetes mellitus]
Digestive System Diseases
A COMPARISON OF SERUM AMINOPEPTIDASE AND ALKALINE PHOSPHATASE IN THE DETECTION OF HEPATOBILIARY DISEASE IN ANICTERIC PATIENTS.
The hepatobiliary disease marker serum alanine aminopeptidase predominantly comprises an isoform of the haematological myeloid differentiation antigen and leukaemia marker CD-13/gp150.
[Electrophoretic variants of alanine aminopeptidase in serum of patients with hepatobiliary diseases]
[Glycylproline dipeptidyl aminopeptidase activity in the sera from patients with hepatobiliary diseases (author's transl)]
[Glycylprolyl dipeptidyl aminopeptidase activity in healthy subjects and patients with hepatobiliary diseases]
[Studies on the specificity of alanine aminopeptidase and its variants in the serum in hepatobiliary diseases]
[The angiotensinase activity of -L-asparaginyl aminopeptidase in the serum of normal subjects, in patients with hepatobiliary diseases and during pregnancy]
Dirofilariasis
Evaluation of urinary enzymes in dogs with early renal disorder.
Dysgerminoma
Oxytocinase-like enzyme in an ovarian dysgerminoma: a placenta-specific protein.
Encephalomyelitis
Changes in the expression pattern of blood-brain barrier-associated pericytic aminopeptidase N (pAP N) in the course of acute experimental autoimmune encephalomyelitis.
DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis.
PETIR-001, a dual inhibitor of dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN), ameliorates experimental autoimmune encephalomyelitis in SJL/J mice.
Review: Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Encephalomyelitis, Autoimmune, Experimental
Changes in the expression pattern of blood-brain barrier-associated pericytic aminopeptidase N (pAP N) in the course of acute experimental autoimmune encephalomyelitis.
PETIR-001, a dual inhibitor of dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN), ameliorates experimental autoimmune encephalomyelitis in SJL/J mice.
Review: Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Endometriosis
Expression of aminopeptidase N and neutral endopeptidase on the endometrial stromal cells in endometriosis and adenomyosis.
Enteritis
[Clinical importance of the determination of intestinal dipeptidase and enterokinase activity in patients with chronic enteritis]
[Dipeptidase activity in the small intestine of patients with chronic nonspecific enteritis]
[Disorders of dipeptidase activity of the small intestine in chronic enteritis and their treatment]
Esophageal Neoplasms
In Vitro Radiosensitization of Esophageal Cancer Cells with the Aminopeptidase Inhibitor CHR-2797.
Essential Hypertension
Circulating Aminopeptidase Activities in Men and Women with Essential Hypertension.
Heightened pressor effect and dipsogenicity to intracerebroventricularly applied angiotensin II and III in spontaneously hypertensive rats.
Significance of the measurement of urinary alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase activity in evaluating patients with essential hypertension.
[Determination of enzyme activity and beta 2-microglobulin concentration in the urine in chronic diffuse glomerulonephritis and hypertension]
Fanconi Syndrome
A low molecular weight alanine aminopeptidase in urine. Biochemical equivalent of tubular atrophy?
Feline Infectious Peritonitis
Analysis of the mechanism of antibody-dependent enhancement of feline infectious peritonitis virus infection: aminopeptidase N is not important and a process of acidification of the endosome is necessary.
Characterization of determinants involved in the feline infectious peritonitis virus receptor function of feline aminopeptidase N.
Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus.
Interspecies aminopeptidase-N chimeras reveal species-specific receptor recognition by canine coronavirus, feline infectious peritonitis virus, and transmissible gastroenteritis virus.
Intriguing interplay between feline infectious peritonitis virus and its receptors during entry in primary feline monocytes.
Targeting non-human coronaviruses to human cancer cells using a bispecific single-chain antibody.
TNF-alpha, produced by feline infectious peritonitis virus (FIPV)-infected macrophages, upregulates expression of type II FIPV receptor feline aminopeptidase N in feline macrophages.
Fibromyalgia
Altered Serum Oxytocinase and Enkephalin-Degrading Aminopeptidase Activities in Patients With Fibromyalgia.
Associations Among Nitric Oxide and Enkephalinases With Fibromyalgia Symptoms.
Fibrosarcoma
Bestatin analogue from Streptomyces neyagawaensis SL-387.
Inhibition of tumor cell invasion and matrix degradation by aminopeptidase inhibitors.
Synthesis and evaluation of novel Tc-99?m labeled NGR-containing hexapeptides as tumor imaging agents.
Gallstones
Biliary aminopeptidase-N and the cholesterol crystallisation defect in cholelithiasis.
Cholesterol saturation, not proteins or cholecystitis, is critical for crystal formation in human gallbladder bile.
Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: soluble pronucleating proteins in gallbladder and hepatic biles.
Gastroenteritis
A phage-displayed peptide recognizing porcine aminopeptidase N is a potent small molecule inhibitor of PEDV entry.
Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry.
Aminopeptidase N-null neonatal piglets are protected from transmissible gastroenteritis virus but not porcine epidemic diarrhea virus.
Binding characterization of determinants in porcine aminopeptidase N, the cellular receptor for transmissible gastroenteritis virus.
Binding of transmissible gastroenteritis coronavirus to cell surface sialoglycoproteins.
Cellular receptors for transmissible gastroenteritis virus on porcine enterocytes.
Characterization of determinants involved in the feline infectious peritonitis virus receptor function of feline aminopeptidase N.
Characterization of functional domains in the human coronavirus HCV 229E receptor.
Contribution of porcine aminopeptidase N to porcine deltacoronavirus infection.
Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct from the enzymatic site.
Feline aminopeptidase N is a receptor for all group I coronaviruses.
Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus.
Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I.
Further characterization of aminopeptidase-N as a receptor for coronaviruses.
Generation of a mouse scFv library specific for porcine aminopeptidase N using the T7 phage display system.
Identification of a putative cellular receptor 150 kDa polypeptide for porcine epidemic diarrhea virus in porcine enterocytes.
Interspecies aminopeptidase-N chimeras reveal species-specific receptor recognition by canine coronavirus, feline infectious peritonitis virus, and transmissible gastroenteritis virus.
Mutational analysis of aminopeptidase N, a receptor for several group 1 coronaviruses, identifies key determinants of viral host range.
Obtention of porcine aminopeptidase-n transgenic mice and analysis of their susceptibility to transmissible gastroenteritis virus.
Overexpression of TGEV cell receptor impairs the production of virus particles.
Phage displayed peptides recognizing porcine aminopeptidase N inhibit transmissible gastroenteritis coronavirus infection in vitro.
Porcine aminopeptidase N is a functional receptor for the PEDV coronavirus.
Porcine Deltacoronavirus Engages the Transmissible Gastroenteritis Virus Functional Receptor Porcine Aminopeptidase N for Infectious Cellular Entry.
Role of Porcine Aminopeptidase N and Sialic Acids in Porcine Coronavirus Infections in Primary Porcine Enterocytes.
The coronavirus transmissible gastroenteritis virus causes infection after receptor-mediated endocytosis and acid-dependent fusion with an intracellular compartment.
[Porcine aminopeptidase N is a functional receptor for the PEDV coronavirus]
Gastroenteritis, Transmissible, of Swine
A phage-displayed peptide recognizing porcine aminopeptidase N is a potent small molecule inhibitor of PEDV entry.
Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry.
Cellular receptors for transmissible gastroenteritis virus on porcine enterocytes.
Characterization of functional domains in the human coronavirus HCV 229E receptor.
Feline aminopeptidase N is a receptor for all group I coronaviruses.
Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I.
Generation of a mouse scFv library specific for porcine aminopeptidase N using the T7 phage display system.
Mutational analysis of aminopeptidase N, a receptor for several group 1 coronaviruses, identifies key determinants of viral host range.
Gastrointestinal Diseases
Immunoelectrophoretic studies on human small intestinal brush border proteins. A quantitative study of brush border enzymes from single small intestinal biopsies.
Gastrointestinal Neoplasms
Circulating carnosine dipeptidase 1 associates with weight loss and poor prognosis in gastrointestinal cancer.
Gingivitis
Trypsin-like, chymotrypsin-like and glycylprolyl dipeptidase activities in gingival crevicular fluid from human periodontal sites with gingivitis.
Glioblastoma
Biomarker discovery: a proteomic approach for brain cancer profiling.
Glioma
Differential Effects of Doxazosin on Renin-Angiotensin-System-Regulating Aminopeptidase Activities in Neuroblastoma and Glioma Tumoral Cells.
Regulation of aminopeptidase A in human brain tumor vasculature: evidence for a role of transforming growth factor-beta.
Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas.
Glomerulonephritis
Diagnostic value of the aminopeptidase N, N-acetyl-beta-D-glucosaminidase and dipeptidylpeptidase IV in evaluating tubular dysfunction in patients with glomerulopathies.
Diagnostic value of urinary alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase in comparison to alpha 1-microglobulin as a marker in evaluating tubular dysfunction in glomerulonephritis patients.
Urinary trehalase activity in chronic glomerulonephritis.
[A method of separate determination of enzymuria associated with impairment of glomerular filtration in kidney tissue]
[Determination of enzyme activity and beta 2-microglobulin concentration in the urine in chronic diffuse glomerulonephritis and hypertension]
Glycosuria
Mild renal failure induced by subchronic exposure to molybdenum: urinary kallikrein excretion as a marker of distal tubular effect.
Renal excretion of ascorbic acid in insulin dependent diabetes mellitus.
Granuloma
Characterization of two dipeptidases purified from hepatic schistosome egg granulomas in mice. Leukotriene D4 hydrolases of granulomatous tissue.
Dipeptidase activity in rat carrageenin granuloma.
Leucine and alanine aminopeptidase activities in experimentally induced intradermal granulomas and late stages of wound healing in the rat.
Morphogenesis and pathogenesis of chronic lung diseases. XI. Histoenzymatic study of the experimentally developing lung granulomas.
The value of modern morphological methods (histochemistry, immunopathology) in sarcoidosis.
Graves Disease
Interleukin-6 (IL-6) inhibits thyroid function in the presence of soluble IL-6 receptor in cultured human thyroid follicles.
Heart Failure
Bioinformatics identification of potential candidate blood indicators for doxorubicin-induced heart failure.
Hematologic Diseases
[Behavior of the dipeptidase (dl-alanylglycine) of the leukocytes of the peripheral blood in some blood diseases.]
Hematologic Neoplasms
Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells.
Hepatitis
Serum pyroglutamyl aminopeptidase activity: a promising novel biomarker candidate for liver cirrhosis.
Targeting non-human coronaviruses to human cancer cells using a bispecific single-chain antibody.
Viral protein synthesis in mouse hepatitis virus strain A59-infected cells: effect of tunicamycin.
[Effect of glucocorticoids (GCS) on the enzyme activity in viral hepatitis (VH). II. Isoenzymatic profile of leucine aminopeptidase (LAP) and glycyl aminopeptidase (GAP) of blood serum]
[Effects of glucocorticoids on enzyme activity in viral hepatitis. I. Behavior of serum leucine aminopeptidase and glycine aminopeptidase]
[Renal changes in viral hepatitis evaluated on the bases of gamma-glutamyltransferase and alanyl aminopeptidase activities in the urine of patients]
[Suitability of "classical" leucine aminopeptidase (LAP) as indicator enzyme in hepatitis epidemica acuta. Differentiation between leucine aminopeptidase and arylamidase in hepatobiliary illnesses]
Hepatoblastoma
Prognostic significance of Aminopeptidase-N (CD13) in hepatoblastoma.
Herpes Zoster
Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters.
Histiocytoma, Malignant Fibrous
Identification of APN/CD13 as the target antigen of FU3, a human monoclonal antibody that recognizes malignant fibrous histiocytoma.
Histoplasmosis
Detection of Histoplasma capsulatum from clinical specimens by cycling probe-based real-time PCR and nested real-time PCR.
N-acetylated ?-linked acidic dipeptidase is identified as an antigen of Histoplasma capsulatum.
Huntington Disease
Changes in nine enzyme markers for neurons, glia, and endothelial cells in agonal state and Huntington's disease caudate nucleus.
Oxidative stress and plasma aminopeptidase activity in Huntington's disease.
Hydatidiform Mole
Studies of serum aminopeptidase in pregnancy, hydatidiform mole, and choriocarcinoma.
Hyperalgesia
Inflammation Mobilizes Local Resources to Control Hyperalgesia: The Role of Endogenous Opioid Peptides.
Hypercholesterolemia
Diet-induced hypercholesterolemia impaired testicular steroidogenesis in mice through the renin-angiotensin system.
Hypersensitivity
Heightened blood pressure and drinking responsiveness to intracerebroventricularly applied angiotensins in the spontaneously hypertensive rat.
Hypertension and angiotensin II hypersensitivity in aminopeptidase A-deficient mice.
Hypertension
A lack of coordination in the release of urinary lysosomal and brush border enzymes following renovascular surgery.
Acetaldehyde inhibits serum aminopeptidases.
Activities of aminopeptidases in a rat saline model of volume hypertension.
Aminopeptidase N in arterial hypertension.
Aminopeptidase N reduces basolateral Na+ -K+ -ATPase in proximal tubule cells.
An in-depth examination of the excretion of albumin and other sensitive markers of renal damage in mild hypertension.
Combinatorial inhibition of Angiotensin converting enzyme, Neutral endopeptidase and Aminopeptidase N by N-methylated peptides alleviates blood pressure and fibrosis in rat model of dexamethasone-induced hypertension.
Dietary NaCl regulates renal aminopeptidase N: relevance to hypertension in the Dahl rat.
Firibastat: A Novel Brain Aminopeptidase Inhibitor - A New Era of Antihypertensive therapy.
Functional polymorphism of the Anpep gene increases promoter activity in the Dahl salt-resistant rat.
Heightened pressor effect and dipsogenicity to intracerebroventricularly applied angiotensin II and III in spontaneously hypertensive rats.
Hypertension and angiotensin II hypersensitivity in aminopeptidase A-deficient mice.
Intrarenal Angiotensin III Is the Predominant Agonist for Proximal Tubule Angiotensin Type 2 Receptors.
Oleate, linoleate and cholesterol differently modify aspartyl- and glutamyl-aminopeptidase activities in primary cultures of rat astrocytes.
Relationships among alterations in renal membrane sodium transport, renin and aminopeptidase M activities in genetic hypertension.
Renal aminopeptidase activities in animal models of hypertension.
Significance of the measurement of urinary alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase activity in evaluating patients with essential hypertension.
[Activity of aminopeptidase towards angiotensin II-amide in the serum during normal health, pregnancy, hypertension and liver disease]
[Renal dipeptidylpeptidase IV excretion in drug-induced kidney changes]
Hypertension, Renal
[The effect of aminopeptidase on experimental renal hypertension in rats]
Hypertension, Renovascular
Aminopeptidase activity in renovascular hypertension.
Angiotensinase activities in the kidney of renovascular hypertensive rats.
Renal aminopeptidase activities in animal models of hypertension.
Reversal of renovascular hypertension by antibodies specific for angiotensin-converting enzyme.
Hyperthyroidism
Angiotensinase activity in hypothalamus and pituitary of hypothyroid, euthyroid and hyperthyroid adult male rats.
Cystinyl and pyroglutamyl-beta-naphthylamide hydrolyzing activities are modified coordinately between hypothalamus, liver and plasma depending on the thyroid status of adult male rats.
Influence of thyroid disorders on kidney angiotensinase activity.
Thyroid Disorders Change the Pattern of Response of Angiotensinase Activities in the Hypothalamus-Pituitary-Adrenal Axis of Male Rats.
[Aminopeptidases in the serum and urine of patients with hyperthyroidism]
Hypokalemia
Tubular damage in patients with hypokalaemia.
Idiopathic Pulmonary Fibrosis
The significance of cathepsins, thrombin and aminopeptidase in diffuse interstitial lung diseases.
Immune System Diseases
Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.
Infections
A phage-displayed peptide recognizing porcine aminopeptidase N is a potent small molecule inhibitor of PEDV entry.
Acquisition of macrophage tropism during the pathogenesis of feline infectious peritonitis is determined by mutations in the feline coronavirus spike protein.
Aminopeptidase activity in the brains of mice with chronic Toxoplasma gondii infections.
Aminopeptidase N Expression, Not Interferon Responses, Determines the Intestinal Segmental Tropism of Porcine Deltacoronavirus.
Aminopeptidase secreted by Chromobacterium sp. Panama inhibits dengue virus infection by degrading the E protein.
Aminopeptidase T of M29 Family Acts as A Novel Intracellular Virulence Factor for Listeria monocytogenes Infection.
Aminopeptidases as potential targets for the control of the Australian sheep blowfly, Lucilia cuprina.
An M29 Aminopeptidase from Listeria Monocytogenes Contributes to In Vitro Bacterial Growth but not to Intracellular Infection.
Analysis of Structures, Functions, and Epitopes of Aminopeptidase from Trichinella spiralis.
Analysis of the mechanism of antibody-dependent enhancement of feline infectious peritonitis virus infection: aminopeptidase N is not important and a process of acidification of the endosome is necessary.
Binding of transmissible gastroenteritis coronavirus to cell surface sialoglycoproteins.
CD13 (human aminopeptidase N) mediates human cytomegalovirus infection.
Changes and induction of aminopeptidase activities in response to pathogen infection during germination of pigeonpea (Cajanas cajan) seeds.
Characterization of a recombinant canine coronavirus with a distinct receptor-binding (S1) domain.
Characterization of porcine epidemic diarrhea virus infectivity in human embryonic kidney cells.
Characterization of the interaction between recombinant porcine aminopeptidase N and spike glycoprotein of porcine epidemic diarrhea virus.
Contribution of porcine aminopeptidase N to porcine deltacoronavirus infection.
Control of IFN-I responses by the aminopeptidase IRAP in neonatal C57BL/6 alveolar macrophages during RSV infection.
Corrigendum: Endoplasmic Reticulum Associated Aminopeptidase 2 (ERAP2) Is Released in the Secretome of Activated MDMs and Reduces in vitro HIV-1 Infection.
Cutting edge: activation of virus-specific CD4 T cells throughout ?-herpesvirus latency.
Development of an effective fluorescence probe for discovery of aminopeptidase inhibitors to suppress biofilm formation.
Diagnostic potential of urinary enzymes and beta 2-microglobulin in acute urinary tract infection.
Differential sensitivity of bat cells to infection by enveloped RNA viruses: coronaviruses, paramyxoviruses, filoviruses, and influenza viruses.
Endoplasmic Reticulum Associated Aminopeptidase 2 (ERAP2) Is Released in the Secretome of Activated MDMs and Reduces in vitro HIV-1 Infection.
Epstein-Barr virus recombinant lacking expression of glycoprotein gp150 infects B cells normally but is enhanced for infection of epithelial cells.
Extracellular aminopeptidase modulates biofilm development of Pseudomonas aeruginosa by affecting matrix exopolysaccharide and bacterial cell death.
Factors affecting susceptibility to RNA interference in Haemonchuscontortus and in vivo silencing of an H11 aminopeptidase gene.
Genetic Control of Human Infection with SARS-CoV-2.
Human aminopeptidase N is a receptor for human coronavirus 229E.
Human cytomegalovirus infection downregulates expression of the cellular aminopeptidases CD10 and CD13.
In vivo function of a gammaherpesvirus virion glycoprotein: influence on B-cell infection and mononucleosis.
Infection of HeLa cells by avian infectious bronchitis virus is dependent on cell status.
Influence of Leishmania infection on blood-meal digestion in the sandflies Phlebotomus papatasi and P. langeroni.
Integrin ?v?3 enhances replication of porcine epidemic diarrhea virus on Vero E6 and porcine intestinal epithelial cells.
Involvement of aminopeptidase N (CD13) in infection of human neural cells by human coronavirus 229E.
Link of a ubiquitous human coronavirus to dromedary camels.
Metalloprotease ADAM17 regulates porcine epidemic diarrhea virus infection by modifying aminopeptidase N.
Molecular Characterization and Biological Function of a Novel LncRNA CRNG in Swine.
Molecular cloning and analysis of the Cryptosporidium parvum aminopeptidase N gene.
Murine gammaherpesvirus 68 lacking gp150 shows defective virion release but establishes normal latency in vivo.
Obtention of porcine aminopeptidase-n transgenic mice and analysis of their susceptibility to transmissible gastroenteritis virus.
Partial protection with a chimeric tetraspanin-leucine aminopeptidase subunit vaccine against Opisthorchis viverrini infection in hamsters.
Peptidase N encoded by Salmonella enterica serovar Typhimurium modulates systemic infection in mice.
Porcine aminopeptidase N mediated polarized infection by porcine epidemic diarrhea virus in target cells.
Porcine epidemic diarrhea virus (PEDV) co-infection induced chlamydial persistence/stress does not require viral replication.
Proteasome activator and antigen-processing aminopeptidases are regulated by virus-induced type I interferon in the hepatitis C virus-infected liver.
Pseudomonas aeruginosa Leucine Aminopeptidase Influences Early Biofilm Composition and Structure via Vesicle-Associated Antibiofilm Activity.
Resistance to coronavirus infection in amino peptidase N-deficient pigs.
Roles of Salmonella enterica serovar Typhimurium encoded Peptidase N during systemic infection of Ifn?(-/-) mice.
Sialic acid binding properties of soluble coronavirus spike (S1) proteins: differences between infectious bronchitis virus and transmissible gastroenteritis virus.
Single-cell RNA sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium.
The Activity of a Hexameric M17 Metallo-Aminopeptidase Is Associated With Survival of Mycobacterium tuberculosis.
The BDLF3 gene product of Epstein-Barr virus, gp150, mediates non-productive binding to heparan sulfate on epithelial cells and only the binding domain of CD21 is required for infection.
The bovine herpesvirus 4 Bo10 gene encodes a nonessential viral envelope protein that regulates viral tropism through both positive and negative effects.
The effect of Eimeria maxima infection on the expression of amino acid and sugar transporters aminopeptidase, as well as the di- and tri-peptide transporter PepT1, is not solely due to decreased feed intake.
The murine gammaherpesvirus-68 gp150 acts as an immunogenic decoy to limit virion neutralization.
The use of cells from ANPEP knockout pigs to evaluate the role of aminopeptidase N (APN) as a receptor for porcine deltacoronavirus (PDCoV).
The virus-host interface: Molecular interactions of Alphacoronavirus-1 variants from wild and domestic hosts with mammalian aminopeptidase N.
Tight junction protein occludin is a porcine epidemic diarrhea virus entry factor.
Type II Secretion-Dependent Aminopeptidase LapA and Acyltransferase PlaC Are Redundant for Nutrient Acquisition during Legionella pneumophila Intracellular Infection of Amoebas.
Infertility
Enkephalin-degrading enzymes in normal and subfertile human semen.
Identification of the structural gene for dipeptidyl aminopeptidase yscV (DAP2) of Saccharomyces cerevisiae.
[Changes in the enzyme level of the sperm of men with infertility]
Inflammatory Bowel Diseases
Functional Genomics and Its Bench-to-Bedside Translation Pertaining to the Identified Susceptibility Alleles and Loci in Ankylosing Spondylitis.
Inflammatory bowel diseases: multiple benefits from therapy with dipeptidyl- and alanyl-aminopeptidase inhibitors.
Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13)--a novel approach for the treatment of inflammatory bowel disease.
Influenza, Human
Time-dependent viral interference between influenza virus and coronavirus in the infection of differentiated porcine airway epithelial cells.
Insulin Resistance
Effects of aerobic exercise on microalbuminuria and enzymuria in type 2 diabetic patients.
[Obesity, inflammation and insulin resistance: role of gp 130 receptor ligands]
Intervertebral Disc Degeneration
Correlation Between Proteolytic Enzymes and Microangiogenesis in Degenerative Intervertebral Disc Nucleus.
Ischemic Attack, Transient
Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia.
Keratosis
Aminopeptidase M and dipeptidyl peptidase IV activity in epithelial skin tumors: a histochemical study.
Keratosis, Seborrheic
Aminopeptidase M and dipeptidyl peptidase IV activity in epithelial skin tumors: a histochemical study.
Kidney Diseases
A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.
Confirming the utility of four kidney biomarker tests in a longitudinal follow-up study.
Multiple forms of alanine aminopeptidase, alkaline phosphatase and gamma-glutamyltransferase in urine of healthy persons, patients suffering from kidney diseases and patients with kidney transplants.
Kidney Diseases, Cystic
Structure of the human aminopeptidase XPNPEP3 and comparison of its in vitro activity with Icp55 orthologs: Insights into diverse cellular processes.
Kidney Failure, Chronic
Aminopeptidase activity in the livers of rats with experimental chronic renal failure.
Behaviour of urinary dipeptidase in patients with chronic renal failure.
Differentiation of acute renal failure and chronic renal failure by 2-dimensional analysis of urinary dipeptidase versus serum creatinine.
Urinary trehalase activity in chronic glomerulonephritis.
Kidney Neoplasms
Arylamidase from human renal cancer tissue in comparison with normal kidney and placental enzymes.
Decreases of metallothionein and aminopeptidase N in renal cancer tissues.
Latent Infection
Natural history of murine gamma-herpesvirus infection.
Leishmaniasis
Enzymuria as an index of renal damage in canine leishmaniasis.
Structural and Functional Basis of Potent Inhibition of Leishmanial Leucine Aminopeptidase by Peptidomimetics.
Leukemia
A mutation in aminopeptidase N (CD13) isolated from a patient suffering from leukemia leads to an arrest in the endoplasmic reticulum.
Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane.
Analysis of the characteristics and expression profiles of coding and noncoding RNAs of human dental pulp stem cells in hypoxic conditions.
Augmentation of death ligand-induced apoptosis by aminopeptidase inhibitors in human solid tumor cell lines.
Differential expression of metastasis-associated cell surface glycoproteins and mRNA in a murine large cell lymphoma.
Efficacy of tosedostat, a novel, oral agent for elderly patients with relapsed or refractory acute myeloid leukemia: a review of the Phase II OPAL trial.
Oncostatin M regulation of interleukin-6 expression in astrocytes: biphasic regulation involving the mitogen-activated protein kinases ERK1/2 and p38.
Studies on aminopeptidase activity in acute non-lymphocytic leukemia. The relation to peroxidase reaction.
Surface aminopeptidase activity of rat natural killer cells. I. Biochemical and biological properties.
The Analgesic Activity of Bestatin as a Potent APN Inhibitor.
[Effect of aminopeptidase inhibitor on differentiation induction activity of all-trans retinoic acid in human acute promyelocytic leukemia NB4 cells and its mechanism]
[Experimental study of the enhancement effect of aminopeptidase N inhibitor ubenimex on the differentiation induction activity of all-trans-retinoic acid in acute promyelocytic leukemia cells and its mechanism]
Leukemia, Lymphoid
Aminopeptidase-N (CD13; gp 150): contrasting patterns of enzymatic activity in blood from patients with myeloid or lymphoid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Purification and characterization of a ubenimex (Bestatin)-sensitive aminopeptidase B-like enzyme from K562 human chronic myeloid leukemia cells.
Leukemia, Myeloid
Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.
Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells.
Leukemia, Myeloid, Acute
Aminopeptidase inhibition by the novel agent CHR-2797 (tosedostat) for the therapy of acute myeloid leukemia.
Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells.
In vitro and in vivo anti-leukemic activity of the peptidase-potentiated alkylator melflufen in acute myeloid leukemia.
Microfluidic chemical cytometry of peptide degradation in single drug-treated acute myeloid leukemia cells.
Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.
Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells.
Positioning of aminopeptidase inhibitors in next generation cancer therapy.
Leukemia, Promyelocytic, Acute
[Effect of aminopeptidase inhibitor on differentiation induction activity of all-trans retinoic acid in human acute promyelocytic leukemia NB4 cells and its mechanism]
[Experimental study of the enhancement effect of aminopeptidase N inhibitor ubenimex on the differentiation induction activity of all-trans-retinoic acid in acute promyelocytic leukemia cells and its mechanism]
Listeriosis
An M29 Aminopeptidase from Listeria Monocytogenes Contributes to In Vitro Bacterial Growth but not to Intracellular Infection.
Liver Cirrhosis
Serum pyroglutamyl aminopeptidase activity: a promising novel biomarker candidate for liver cirrhosis.
Liver Diseases
Alanine aminopeptidase in serum: automated optimized assay, and effects of age, sex, smoking, and alcohol consumption in a selected population.
Clinical significance of a new isoform of serum alanine aminopeptidase; relationship with liver disease and alcohol consumption.
Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes.
High-molecular-mass isoform of aminopeptidase N/CD13 in serum from cholestatic patients.
Intra-individual variation of analytes in serum from patients with chronic liver diseases.
Multiple forms of gamma-glutamyltransferase: a clinical study.
[Activity of aminopeptidase towards angiotensin II-amide in the serum during normal health, pregnancy, hypertension and liver disease]
[Clinical significance of glycylproline dipeptidyl aminopeptidase activity and isoenzyme patterns in the sera of patients with liver diseases]
[Clinical significance of glycylproline dipeptidyl aminopeptidase in liver diseases (author's transl)]
Liver Diseases, Alcoholic
Beta-hexosaminidase, leucine aminopeptidase, cystidyl aminopeptidase, hepatic enzymes and bilirubin in serum of chronic alcoholics with acute ethanol intoxication.
Liver Neoplasms
Aminopeptidase N inhibitor 4cc synergizes antitumor effects of 5-fluorouracil on human liver cancer cells through ROS-dependent CD13 inhibition.
Aminopeptidases and arylamidases in normal and cancer tissues in humans.
Bone morphogenetic protein-9 is a potent growth inhibitor of hepatocellular carcinoma and reduces the liver cancer stem cells population.
Getting to the heart of the matter in cancer: Novel approaches to targeting cancer stem cells.
Glycylproline dipeptidyl aminopeptidase and gamma-glutamyl transpeptidase in human hepatic cancer and embryonal tissues.
Serum and liver glycylproline dipeptidyl aminopeptidase activity in rats with experimental hepatic cancer.
Serum glycylproline dipeptidyl aminopeptidase activity in human hepatic cancer.
[Evaluation of serum glycylproline dipeptidyl aminopeptidase activity in the diagnosis of primary liver cancer]
Lung Diseases, Interstitial
CD13/aminopeptidase N in collagen vascular diseases.
The significance of cathepsins, thrombin and aminopeptidase in diffuse interstitial lung diseases.
Lung Neoplasms
Aminopeptidases and arylamidases in normal and cancer tissues in humans.
CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells.
Circulating aminopeptidase N/CD13 is an independent prognostic factor in patients with non-small cell lung cancer.
Clinical significance of aminopeptidase N in non-small cell lung cancer.
Expression and clinical significance of aminopeptidase N/CD13 in non-small cell lung cancer.
N-acetylalanine aminopeptidase activity in normal and tumour cells.
Neutral endopeptidase/CD10 and aminopeptidase N/CD13 gene expression as a prognostic factor in non-small cell lung cancer.
Positioning of aminopeptidase inhibitors in next generation cancer therapy.
Stromal aminopeptidase N expression: correlation with angiogenesis in non-small-cell lung cancer.
Lupus Erythematosus, Systemic
CD13/aminopeptidase N in collagen vascular diseases.
[The value of urinary enzyme determinations in systemic lupus erythematosus (author's transl)]
Lupus Nephritis
Diagnostic value of the aminopeptidase N, N-acetyl-beta-D-glucosaminidase and dipeptidylpeptidase IV in evaluating tubular dysfunction in patients with glomerulopathies.
Lyme Disease
The thermophilic, homohexameric aminopeptidase of Borrelia burgdorferi is a member of the M29 family of metallopeptidases.
Lymphatic Metastasis
AZGP1 and SPDEF mRNA expression differentiates breast carcinoma from ovarian serous carcinoma.
Clinicopathological significance of aminopeptidase N/CD13 expression in human gastric carcinoma.
Expression and clinical significance of aminopeptidase N/CD13 in non-small cell lung cancer.
Lymphedema
Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells.
Lymphoma
A novel mammalian high-molecular-weight aminopeptidase.
Ability of the immunomodulating dipeptide bestatin to activate cytotoxic mononuclear phagocytes.
Enhancement of tumor necrosis factor alpha antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13).
Histochemistry of dipeptidyl aminopeptidase (DAP) II and IV in reactive lymphoid tissues and malignant lymphoma.
Lymphoma, B-Cell
Emerging therapies for acute myeloid leukemia.
Lymphoma, T-Cell
The aminopeptidase activity in the human T-cell lymphoma line (Jurkat) is not at the cell surface and is not aminopeptidase N (CD-13).
Malabsorption Syndromes
The activities of alanine aminopeptidase, leucine aminopeptidase, proline dipeptidase and prolyl dipeptidase in the mucosa of the small intestine. Investigations on normal children and patients with the malabsorption syndrome.
[Intestinal dipeptidase and disaccharidase activity in malabsorption syndrome in children]
Malaria
3'-RACE Amplification of Aminopeptidase N Gene from Anopheles stephensi Applicable in Transmission Blocking Vaccines.
A comprehensive analysis of amino-peptidase N1 protein (APN) from Anopheles culicifacies for epitope design using Immuno-informatics models.
Biochemical characterization of aminopeptidase N2 from Toxoplasma gondii.
Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors.
Comparative proteomics and functional analysis reveal a role of P. falciparum osmiophilic bodies in malaria parasite transmission.
Identification and Characterization of Aminopeptidase N 1 Gene of the Indian Malaria Vector Anopheles culicifacies (Diptera: Culicidae).
Identification, molecular characterization and expression of aminopeptidase N-1 (APN-1) from Anopheles stephensi in SF9 cell line as a candidate molecule for developing a vaccine that interrupt malaria transmission.
Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite.
Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials.
Relationship of chloroquine-induced redistribution of a neutral aminopeptidase to hemoglobin accumulation in malaria parasites.
Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum.
Steered molecular dynamics simulations reveal critical residues for (un)binding of substrates, inhibitors and a product to the malarial M1 aminopeptidase.
Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors.
The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria.
The Anopheles-midgut APN1 structure reveals a new malaria transmission-blocking vaccine epitope.
The Plasmodium falciparum malaria M1 alanyl aminopeptidase (PfA-M1): insights of catalytic mechanism and function from MD simulations.
Two cap residues in the S1 subsite of a Plasmodium falciparum M1-family aminopeptidase promote broad specificity and enhance catalysis.
X-ray Crystal Structure and Specificity of the Plasmodium falciparum Malaria Aminopeptidase PfM18AAP.
Malaria, Falciparum
The Plasmodium falciparum malaria M1 alanyl aminopeptidase (PfA-M1): insights of catalytic mechanism and function from MD simulations.
X-ray Crystal Structure and Specificity of the Plasmodium falciparum Malaria Aminopeptidase PfM18AAP.
Malnutrition
Effect of moderate malnutrition on concentrations of immunoglobulins and enzymes in tears and saliva of young Colombian children.
Influence of malnutrition on the concentration of IgA, lysozyme, amylase and aminopeptidase in children's tears.
Medulloblastoma
[Growth promoting effect of IL-6 on medulloblastoma cells in vitro]
Melanoma
A chloride activated alanine aminopeptidase from a melanoma cell line.
Anchorage independence altered vasculogenic phenotype of melanoma cells through downregulation in aminopeptidase N /syndecan-1/integrin ?4 axis.
Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice.
Bestatin and bacitracin inhibit porcine kidney cortex dipeptidyl peptidase IV activity and reduce human melanoma MeWo cell viability.
Biochemical and functional characterization of aminopeptidase N expressed by human melanoma cells.
Cell surface antigens of human malignant melanoma: definition of six antigenic systems with mouse monoclonal antibodies.
Enhancement of tumor necrosis factor alpha antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13).
Expression of the COVID-19 receptor ACE2 in the human conjunctiva.
Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13.
Immunoluminescent detection of intercellular adhesion molecule-1 and aminopeptidase N on human melanoma cells.
MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model.
New phenotypical and ultrastructural findings in spindle cell (desmoplastic/neurotropic) melanoma.
Promoter methylation of aminopeptidase N/CD13 in malignant melanoma.
Selection Signatures Analysis Reveals Genes Associated with High-Altitude Adaptation in Tibetan Goats from Nagqu, Tibet.
Synthesis of 5-S-L-cysteinyl-glycine-L-dopa, a natural substrate for serum and melanocyte dipeptidase.
[Aminopeptidase in melanoma tissue (author's transl)]
[Renal dipeptidylpeptidase IV excretion in drug-induced kidney changes]
membrane alanyl aminopeptidase deficiency
A patient with neurological symptoms and abnormal leukotriene metabolism: a new defect in leukotriene biosynthesis.
An aminopeptidase N deficiency in dog small intestine.
Dipeptidase deficiency and malabsorption of glycylglycine in disease states.
Inborn errors in the metabolism of glutathione.
[Dipeptidase deficiency]
Meningioma
Reduced Activity of CD13/Aminopeptidase N (APN) in Aggressive Meningiomas Is Associated with Increased Levels of SPARC.
Meningitis
Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.
Meningomyelocele
Fetal anal incontinence evaluated by amniotic fluid digestive enzyme assay in myelomeningocele spina bifida.
Mesothelioma
Aminopeptidase antibodies in mesothelioma: new wine deserves new sacks.
Aminopeptidase N/CD13 as a Potential Therapeutic Target in Malignant Pleural Mesothelioma.
Mesothelioma, Malignant
Aminopeptidase N/CD13 as a Potential Therapeutic Target in Malignant Pleural Mesothelioma.
Motor Neuron Disease
Lix1 knockout mouse does not exhibit spinal muscular atrophy phenotype.
Multiple Myeloma
Aminopeptidase Expression in Multiple Myeloma Associates with Disease Progression and Sensitivity to Melflufen.
The gp 130 family cytokines IL-6, LIF and OSM but not IL-11 can reverse the anti-proliferative effect of dexamethasone on human myeloma cells.
Multiple Sclerosis
Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes.
DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis.
Expression of aminopeptidase N (APN) on peripheral blood mononuclear cells' surface as a marker of these cells' transendothelial migration properties in the course of multiple sclerosis.
Increased expression of neutral endopeptidase (NEP) and aminopeptidase N (APN) on peripheral blood mononuclear cells in patients with multiple sclerosis.
Review: Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
[Increased expression of aminopeptidase N on lymphocytes in multiple sclerosis]
Muscular Atrophy, Spinal
Lix1 knockout mouse does not exhibit spinal muscular atrophy phenotype.
Muscular Dystrophies
Enzyme studies in muscular dystrophy. II. Muscle dipeptidase activity and vitamin E-deficiency.
Myocardial Infarction
AMINOPEPTIDASE ACTIVITY IN MYOCARDIAL INFARCTION OF MAN. A HISTOCHEMICAL STUDY.
Plasma cardiotrophin-1 following acute myocardial infarction: relationship with left ventricular systolic dysfunction.
[Aminopeptidases in the serum following myocardial infarct]
Neoplasm Metastasis
ACO2 and ANPEP as novel prognostic markers for gallbladder squamous cell/adenosquamous carcinomas and adenocarcinomas.
Anchorage independence altered vasculogenic phenotype of melanoma cells through downregulation in aminopeptidase N /syndecan-1/integrin ?4 axis.
APN-mediated phosphorylation of BCKDK promotes hepatocellular carcinoma metastasis and proliferation via the ERK signaling pathway.
AZGP1 and SPDEF mRNA expression differentiates breast carcinoma from ovarian serous carcinoma.
Cell cycle phases of two human lung tumor cell lines derived from squamous cell carcinoma and pulmonary metastasis of a rhabdomyosarcoma (HS 24 and HS 57) and N-acetylalanine aminopeptidase activity.
CIP-13F, a novel aminopeptidase N (APN/CD13) inhibitor, inhibits Lewis lung carcinoma growth and metastasis in mice.
Circulating aminopeptidase N/CD13 is an independent prognostic factor in patients with non-small cell lung cancer.
Clinicopathological significance of aminopeptidase N/CD13 expression in human gastric carcinoma.
Design, synthesis and biological evaluation of novel L-isoserine tripeptide derivatives as aminopeptidase N inhibitors.
Design, synthesis and biological evaluation of novel L-lysine ureido derivatives as aminopeptidase N inhibitors.
Design, synthesis and preliminary activity evaluation of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as aminopeptidase N/CD13 inhibitors.
Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors.
Design, synthesis, and activity evaluation of a new 5-fluorouracil prodrug containing an Asn-Gly-Arg(NO2)COOCH3 tripeptide.
Development of Synthetic Aminopeptidase N/CD13 Inhibitors to Overcome Cancer Metastasis and Angiogenesis.
Distinguishing primary from secondary mucinous ovarian tumors: an algorithm using the novel marker DPEP1.
Ectopeptidases in tumour biology: a review.
Establishment of a screening protocol for identification of aminopeptidase N inhibitors.
Evaluation of (99m)Tc-probestin for imaging APN expressing tumors by SPECT.
Evaluation of an Integrin ?v?3 and Aminopeptidase N Dual-Receptor Targeting Tracer for Breast Cancer Imaging.
Expression and clinical significance of aminopeptidase N/CD13 in non-small cell lung cancer.
Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13.
In vivo imaging of Aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer (68)Ga-NOTA-c(NGR).
Incadronate inhibits aminopeptidase N expression in prostatic PC-3 cells.
Inhibitory effect of anti-aminopeptidase N/CD13 antibodies on fibroblast migration.
Leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry. Part II.
LYP3, a new bestatin derivative for aminopeptidase N inhibition.
MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model.
Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN).
Novel aminopeptidase N (APN/CD13) inhibitors derived from 3-phenylalanyl-N'-substituted-2,6-piperidinedione.
Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine.
Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I).
Novel anticancer targets and drug discovery in post genomic age.
Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions.
Novel indoline-2,3-dione derivatives as inhibitors of aminopeptidase N (APN).
Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry.
Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, synthesis and activity evaluation.
Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN).
Precipitated Fluorophore-Based Molecular Probe for In Situ Imaging of Aminopeptidase N in Living Cells and Tumors.
Recent advances in the development of MMPIs and APNIs based on the pyrrolidine platforms.
Serum APN/CD13 as a novel diagnostic and prognostic biomarker of pancreatic cancer.
Synthesis and 4D-QSAR Studies of Alanine Hydroxamic Acid Derivatives as Aminopeptidase N Inhibitors.
Synthesis and activity evaluation of a new bestatin derivative LYP2 as an aminopeptidase N inhibitor.
Targeting aminopeptidase N (APN/CD13) with cyclic-imide peptidomimetics derivative CIP-13F inhibits the growth of human ovarian carcinoma cells.
Ubenimex, an APN inhibitor, could serve as an anti?tumor drug in RT112 and 5637 cells by operating in an Akt?associated manner.
[Significance of the determination of alanine aminopeptidase and alkaline phosphatase in serum in the detection of osseous osteoplastic metastases]
Neoplasms
11C-MCG: synthesis, uptake selectivity, and primate PET of a probe for glutamate carboxypeptidase II (NAALADase).
13F-1, a novel 5-fluorouracil prodrug containing an Asn-Gly-Arg (NO2) COOCH3 tripeptide, inhibits human colonic carcinoma growth by targeting Aminopeptidase N (APN/CD13).
68Ga-DOTA-NGR as a novel molecular probe for APN-positive tumor imaging using MicroPET.
A clinical evaluation of serological diagnosis for pancreatic cancer.
A comparison of the monomeric [68Ga]NODAGA-NGR and dimeric [68Ga]NOTA-(NGR)2 as aminopeptidase N ligand for positron emission tomography imaging in tumor-bearing mice.
A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells.
A dipeptidase from Ehrlich Lettré mouse ascites tumor cells.
A new class of 5-fluoro-2'-deoxyuridine prodrugs conjugated with a tumor-homing cyclic peptide CNGRC by ester linkers: synthesis, reactivity, and tumor-cell-selective cytotoxicity.
A Phase Ib dose-escalation study to evaluate safety and tolerability of the addition of the aminopeptidase inhibitor tosedostat (CHR-2797) to paclitaxel in patients with advanced solid tumours.
A unified mechanism for aminopeptidase N-based tumor cell motility and tumor-homing therapy.
A-NGR fusion protein induces apoptosis in human cancer cells.
Ability of the immunomodulating dipeptide bestatin to activate cytotoxic mononuclear phagocytes.
ACO2 and ANPEP as novel prognostic markers for gallbladder squamous cell/adenosquamous carcinomas and adenocarcinomas.
Activity and safety of NGR-hTNF, a selective vascular-targeting agent, in previously treated patients with advanced hepatocellular carcinoma.
Activity screening and structure-activity relationship of the hit compounds targeting APN/CD13.
Activity-Based Sensing and Theranostic Probes Based on Photoinduced Electron Transfer.
Addition of an aminopeptidase N-binding sequence to human endostatin improves inhibition of ovarian carcinoma growth.
Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection.
Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma.
Amino acid and dipeptide derivatives of daunorubicin. 1. Synthesis, physicochemical properties, and lysosomal digestion.
Aminopeptidase A initiates tumorigenesis and enhances tumor cell stemness via TWIST1 upregulation in colorectal cancer.
Aminopeptidase activity in cancer cells.
Aminopeptidase Expression in Multiple Myeloma Associates with Disease Progression and Sensitivity to Melflufen.
Aminopeptidase M and dipeptidyl peptidase IV activity in epithelial skin tumors: a histochemical study.
Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer.
Aminopeptidase N (APN/CD13) is selectively expressed in vascular endothelial cells and plays multiple roles in angiogenesis.
Aminopeptidase N (CD13) as a target for cancer chemotherapy.
Aminopeptidase N (CD13) regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils.
Aminopeptidase N (CD13) targeted MR and NIRF dual-modal imaging of ovarian tumor xenograft.
Aminopeptidase N (CD13): Expression, Prognostic Impact, and Use as Therapeutic Target for Tissue Factor Induced Tumor Vascular Infarction in Soft Tissue Sarcoma.
Aminopeptidase N Activatable Fluorescent Probe for Tracking Metastatic Cancer and Image-Guided Surgery via in Situ Spraying.
Aminopeptidase N inhibitor 4cc synergizes antitumor effects of 5-fluorouracil on human liver cancer cells through ROS-dependent CD13 inhibition.
Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.
Aminopeptidase N is involved in cell motility and angiogenesis: its clinical significance in human colon cancer.
Aminopeptidase N regulated by zinc in human prostate participates in tumor cell invasion.
Aminopeptidase N/CD13 as a Potential Therapeutic Target in Malignant Pleural Mesothelioma.
Aminopeptidase N/CD13 targeting fluorescent probes: synthesis and application to tumor cell imaging.
Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.
Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells.
Aminopeptidases and angiotensin I-converting enzyme activities in primary human lung tumors and lung parenchyma.
Anchorage independence altered vasculogenic phenotype of melanoma cells through downregulation in aminopeptidase N /syndecan-1/integrin ?4 axis.
Anti-tumor and anti-angiogenic effect of metronomic cyclic NGR-modified liposomes containing paclitaxel.
Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice.
Antiproliferative effects of palladium(II) complexes of 5-nitrosopyrimidines and interactions with the proteolytic regulatory enzymes of the renin-angiotensin system in tumoral brain cells.
Antisense-mediated inhibition of aminopeptidase N (CD13) markedly decreases growth rates of hematopoietic tumour cells.
APN/CD13-targeting as a strategy to alter the tumor accumulation of liposomes.
Aspartic Aminopeptidase Is a Novel Biomarker of Aggressive Chronic Lymphocytic Leukemia.
Augmentation of death ligand-induced apoptosis by aminopeptidase inhibitors in human solid tumor cell lines.
AZGP1 and SPDEF mRNA expression differentiates breast carcinoma from ovarian serous carcinoma.
Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy.
Basic aminopeptidase activity is an emerging biomarker in collagen-induced rheumatoid arthritis.
Bestatin as an experimental tool in mammals.
Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis.
Binding and internalization of NGR-peptide-targeted liposomal doxorubicin (TVT-DOX) in CD13-expressing cells and its antitumor effects.
Biochemical characterization of aminopeptidase N2 from Toxoplasma gondii.
Biological significance of aminopeptidase N/CD13 in thyroid carcinomas.
Bone marrow-derived CD13(+) cells sustain tumor progression: A potential non-malignant target for anticancer therapy.
Brush border hydrolases in normal and neoplastic colonic epithelium.
Carboplatin (CBDCA), iproplatin (CHIP), and high dose cisplatin in hypertonic saline evaluated for tubular nephrotoxicity.
Catheptic and dipeptidase activities of ascites tumour cells.
CD13 as target for tissue factor induced tumor vascular infarction in small cell lung cancer.
Cell cycle phases of two human lung tumor cell lines derived from squamous cell carcinoma and pulmonary metastasis of a rhabdomyosarcoma (HS 24 and HS 57) and N-acetylalanine aminopeptidase activity.
Cell surface antigens of human malignant melanoma: definition of six antigenic systems with mouse monoclonal antibodies.
Cerenkov Luminescence Tomography of Aminopeptidase N (APN/CD13) Expression in Mice Bearing HT1080 Tumors.
Changes in the dipeptidase and acid proteinase activities in blood plasma of mice carrying ascites tumors.
Chlorin e6 embedded in phospholipid nanoparticles equipped with specific peptides: Interaction with tumor cells with different aminopeptidase N expression.
CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells.
Ciliary neurotrophic factor is an endogenous pyrogen.
CIP-13F, a novel aminopeptidase N (APN/CD13) inhibitor, inhibits Lewis lung carcinoma growth and metastasis in mice.
Circulating aminopeptidase N/CD13 is an independent prognostic factor in patients with non-small cell lung cancer.
Clinical significance of aminopeptidase N in non-small cell lung cancer.
Clinical significance of aminopeptidase N/CD13 expression in human pancreatic carcinoma.
Clinicopathological significance of aminopeptidase N/CD13 expression in human gastric carcinoma.
Combination therapy of radiation and immunomodulators in the treatment of MM46 tumor transplanted in C3H/He mice.
Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma.
Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment.
Correlation between adiponectin polymorphism and atherosclerotic plaque compositions under intravascular ultrasound (IVUS).
Crystal structures of human procathepsin H.
Cytoenzymology of benign and malignant tumours of the corpus uteri. III. Alkaline phosphatase, non-specific esterase and leucine aminopeptidase.
Cytokines and feeding.
Cytokines and glucocorticoids modulate human bronchial epithelial cell peptidases.
Decrease in Dipeptidyl Peptidase IV Activity is Linked to the Efficacy of Differentiating Compounds in Follicular Thyroid Carcinoma Cell Lines.
Defining the optimal biological dose of NGR-hTNF, a selective vascular targeting agent, in advanced solid tumours.
Design and synthesis of a novel peptide for selective detection of cancer cells.
Design, Synthesis and Biological Evaluation of Ketoprofen Conjugated To RGD/NGR for Targeted Cancer Therapy.
Design, synthesis and biological evaluation of novel L-isoserine tripeptide derivatives as aminopeptidase N inhibitors.
Design, synthesis and biological evaluation of novel L-lysine ureido derivatives as aminopeptidase N inhibitors.
Design, synthesis and biological evaluation of peptide-NSAID conjugates for targeted cancer therapy.
Design, synthesis and preliminary activity evaluation of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as aminopeptidase N/CD13 inhibitors.
Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors.
Design, synthesis, and activity evaluation of a new 5-fluorouracil prodrug containing an Asn-Gly-Arg(NO2)COOCH3 tripeptide.
Development of NGR peptide-based agents for tumor imaging.
Development of NGR-based anti-cancer agents for targeted therapeutics and imaging.
Development of Synthetic Aminopeptidase N/CD13 Inhibitors to Overcome Cancer Metastasis and Angiogenesis.
Diagnostic evaluation of alanine aminopeptidase as serum marker for detecting cancer.
Differential Effects of Doxazosin on Renin-Angiotensin-System-Regulating Aminopeptidase Activities in Neuroblastoma and Glioma Tumoral Cells.
Differential regulation of aminopeptidase N (CD13) by transendothelial migration and cytokines on human eosinophils.
Dipeptidase 1 (DPEP1) is a marker for the transition from low-grade to high-grade intraepithelial neoplasia and an adverse prognostic factor in colorectal cancer.
Dipeptidase 1: a candidate tumor-specific molecular marker in colorectal carcinoma.
Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes.
Dipeptidyl peptidase-IV inhibits glioma cell growth independent of its enzymatic activity.
Direct inhibition of human acute myeloid leukemia cell growth by IL-12.
Distinguishing primary from secondary mucinous ovarian tumors: an algorithm using the novel marker DPEP1.
DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway.
Ectopeptidases in tumour biology: a review.
Effect of thyroid hormone-nitric oxide interaction on tumor growth, angiogenesis, and aminopeptidase activity in mice.
Efficient inhibition of tumor angiogenesis and growth by a synthetic peptide blocking S100A4-methionine aminopeptidase 2 interaction.
Elevation of glutathione in phenylalanine mustard-resistant murine L1210 leukemia cells.
Engineered Peptides for Applications in Cancer Targeted Drug Delivery and Tumor Detection.
Enhanced anti-tumor and anti-angiogenic efficacy of a novel liposomal fenretinide on human neuroblastoma.
Enhanced Expression of CD13 in Vessels of Inflammatory and Neoplastic Tissues.
Enhanced expression of CD13 in vessels of inflammatory and neoplastic tissues.
Enhancement of tumor necrosis factor alpha antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13).
Enzyme activity and distribution in rat prostatic adenocarcinoma.
ERAP1 is associated with ankylosing Spondylitis in Han Chinese.
ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism.
Establishment of a screening protocol for identification of aminopeptidase N inhibitors.
Evaluation of (99m)Tc-probestin for imaging APN expressing tumors by SPECT.
Evaluation of an Integrin ?v?3 and Aminopeptidase N Dual-Receptor Targeting Tracer for Breast Cancer Imaging.
Exploration of structural and physicochemical requirements and search of virtual hits for aminopeptidase N inhibitors.
Exploring ligand dissociation pathways from aminopeptidase N using random acceleration molecular dynamics simulation.
Expression and clinical significance of aminopeptidase N/CD13 in non-small cell lung cancer.
Expression and different polarity of aminopeptidase N in normal human colonic mucosa and colonic tumors.
Expression of aminopeptidase N (CD13) in mesenchymal tumors.
Expression of aminopeptidase N on human choriocarcinoma cells and cell growth suppression by the inhibition of aminopeptidase N activity.
Expression of aminopeptidase N/CD13 in human ovarian cancers.
Expression of aminopeptidase-n (CD 13) in normal tissues and malignant neoplasms of epithelial and lymphoid origin.
First-In-Class CD13-Targeted Tissue Factor tTF-NGR in Patients with Recurrent or Refractory Malignant Tumors: Results of a Phase I Dose-Escalation Study.
Fungal lectin MpL enables entry of protein drugs into cancer cells and their subcellular targeting.
Gastric and intestinal phenotypic expressions of human signet ring cell carcinomas revealed by their biochemistry, mucin histochemistry, and ultrastructure.
Gastric- and intestinal-type properties of human gastric cancers transplanted into nude mice.
Getting to the heart of the matter in cancer: Novel approaches to targeting cancer stem cells.
Histochemical study of aminopeptidase in malignant neoplasms of the female genitals.
Histochemical study of aminopeptidase in tumors of the oral region.
Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13.
Identification of gene signatures for invasive colorectal tumor cells.
Improved biological activity of a mutant endostatin containing a single amino-acid substitution.
In situ imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe.
In vitro assessment of the dual-targeting behavior of a peptide-based magnetic resonance imaging contrast agent.
In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy.
In vivo assessment of aminopeptidase N (APN/CD13) specificity of different 68Ga-labelled NGR derivatives using PET/MRI imaging.
In Vivo Coinstantaneous Identification of Hepatocellular Carcinoma Circulating Tumor Cells by Dual-Targeting Magnetic-Fluorescent Nanobeads.
In vivo imaging of Aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer (68)Ga-NOTA-c(NGR).
In Vivo Imaging of Hypoxia and Neoangiogenesis in Experimental Syngeneic Hepatocellular Carcinoma Tumor Model Using Positron Emission Tomography.
In Vivo Molecular Imaging of the Efficacy of Aminopeptidase N (APN/CD13) Receptor Inhibitor Treatment on Experimental Tumors Using 68Ga-NODAGA-c(NGR) Peptide.
Increasing the activity of cell adherent cyclic NGR peptides by optimizing the peptide length and amino acid character.
Infarction of tumor vessels by NGR-peptide-directed targeting of tissue factor: experimental results and first-in-man experience.
iNGR-modified PEG-PLGA nanoparticles that recognize tumor vasculature and penetrate gliomas.
Inhibition by bestatin of a mouse ascites tumor dipeptidase. Reversal by certain substrates.
Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells.
Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer.
Inhibition of Porcine Aminopeptidase M (pAMP) by the Pentapeptide Microginins.
Inhibition of tumor cell invasion and matrix degradation by aminopeptidase inhibitors.
Inhibition of tumor cell invasion by ubenimex (bestatin) in vitro.
Inhibition of tumor invasion and extracellular matrix degradation by ubenimex (bestatin).
Inhibitory effect of anti-aminopeptidase N/CD13 antibodies on fibroblast migration.
Insulin-regulated aminopeptidase/placental leucil Aminopeptidase (IRAP/P-lAP) and angiotensin IV-forming activities are modified in serum of rats with breast cancer induced by N-methyl-nitrosourea.
Intestinal brush-border-associated enzymes: co-ordinated expression in colorectal cancer.
Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo.
Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells.
Isolated tumor endothelial cells maintain specific character during long-term culture.
Kininase I, kininase II and aminopeptidase levels in patients with gastrointestinal tumors.
Leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry. Part II.
Localization of a cathepsin-like and aminopeptidase activity in various solid tumor transplants.
Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast.
LYP3, a new bestatin derivative for aminopeptidase N inhibition.
Macrocyclisation of small peptides enabled by oxetane incorporation.
Macrophage-derived interleukin-6 up-regulates MUC1, but down-regulates MUC2 expression in the human colon cancer HT-29 cell line.
Melflufen - a peptidase-potentiated alkylating agent in clinical trials.
Melphalan-flufenamide is cytotoxic and potentiates treatment with chemotherapy and the Src inhibitor dasatinib in urothelial carcinoma.
miR-125b Acts as a Tumor Suppressor in Breast Tumorigenesis via Its Novel Direct Targets ENPEP, CK2-?, CCNJ, and MEGF9.
Modification of cyclic NGR tumor neovasculature-homing motif sequence to human plasminogen kringle 5 improves inhibition of tumor growth.
Molecular docking studies, biological and toxicity evaluation of dihydroisoquinoline derivatives as potential anticancer agents.
Molecular Imaging of Aminopeptidase N in Cancer and Angiogenesis.
MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model.
Multiple gastric involvement by myeloid antigen CD13-positive non-secretory plasma cell leukaemia.
N-acetylalanine aminopeptidase activity in normal and tumour cells.
Nanocarrier-mediated targeting of tumor and tumor vascular cells improves uptake and penetration of drugs into neuroblastoma.
Nanoparticles targeted with NGR motif deliver c-myc siRNA and doxorubicin for anticancer therapy.
Native Chemical Ligation-Based Fluorescent Probes for Cysteine and Aminopeptidase N Using meso-thioester-BODIPY.
Neutral endopeptidase/CD10 and aminopeptidase N/CD13 gene expression as a prognostic factor in non-small cell lung cancer.
Neutral surface aminopeptidase activity of human tumor cell lines.
New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13.
NGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting.
NGR-based strategies for targeting delivery of chemotherapeutics to tumor vasculature.
NGR-modified micelles enhance their interaction with CD13-overexpressing tumor and endothelial cells.
Noninvasive ratiometric fluorescence imaging of ?-glutamyltransferase activity using an activatable probe.
Novel 3-galloylamido-N'-substituted-2,6-piperidinedione-N-acetamide peptidomimetics as metalloproteinase inhibitors.
Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN).
Novel aminopeptidase N (APN/CD13) inhibitor 24F can suppress invasion of hepatocellular carcinoma cells as well as angiogenesis.
Novel aminopeptidase N (APN/CD13) inhibitors derived from 3-phenylalanyl-N'-substituted-2,6-piperidinedione.
Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine.
Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold.
Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I).
Novel anticancer targets and drug discovery in post genomic age.
Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions.
Novel indoline-2,3-dione derivatives as inhibitors of aminopeptidase N (APN).
Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry.
Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, synthesis and activity evaluation.
Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN).
Noyes-Whitney Dissolution Model-Based pH-Sensitive Slow Release of Paclitaxel (Taxol) from Human Hair-Derived Keratin Microparticle Carriers.
Peptides for cell-selective drug delivery.
Pharmacokinetics of contrast agents targeted to the tumor vasculature in molecular magnetic resonance imaging.
Phase I Study of NGR-hTNF, a Selective Vascular Targeting Agent, in Combination with Cisplatin in Refractory Solid Tumors.
Phase Ib study of NGR-hTNF, a selective vascular targeting agent, administered at low doses in combination with doxorubicin to patients with advanced solid tumours.
Phase II Study of Asparagine-Glycine-Arginine-Human Tumor Necrosis Factor {alpha}, a Selective Vascular Targeting Agent, in Previously Treated Patients With Malignant Pleural Mesothelioma.
Phase II study of NGR-hTNF, a selective vascular targeting agent, in patients with metastatic colorectal cancer after failure of standard therapy.
Positioning of aminopeptidase inhibitors in next generation cancer therapy.
Potential therapeutic impact of CD13 expression in non-small cell lung cancer.
Precipitated Fluorophore-Based Molecular Probe for In Situ Imaging of Aminopeptidase N in Living Cells and Tumors.
Preliminary detection of the anti?tumour activity of indoline?2,3?dione derivative DH?12a targeting aminopeptidase N.
Preparation and comparative evaluation of
Probing the structural and molecular diversity of tumor vasculature.
Prognostic value of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and aminopeptidase N/CD13 in breast cancer patients.
Protein phosphatase type 2A, PP2A, is involved in degradation of gp130.
Proteomic Characterization of Two Medically Important Malaysian Snake Venoms, Calloselasma rhodostoma (Malayan Pit Viper) and Ophiophagus hannah (King Cobra).
Proteomic profiling of the retinal dysplasia and degeneration chick retina.
Proximal CD13 Versus Distal GATA-3 Expression in Renal Neoplasia According to WHO 2016 Classification.
Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro.
Purification and properties of a mouse ascites tumor dipeptidase, a metalloenzyme.
Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis.
Quantitative molecular magnetic resonance imaging of tumor angiogenesis using cNGR-labeled paramagnetic quantum dots.
Radiation synergizes with antitumor activity of CD13-targeted tissue factor in a HT1080 xenograft model of human soft tissue sarcoma.
Rapid and Sensitive Detection of Cancer Cells with Activatable Fluorescent Probes for Enzyme Activity.
Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IV.
Rapid screening of peptide probes through in situ single-bead sequencing microarray.
Recent advances in the development of MMPIs and APNIs based on the pyrrolidine platforms.
Reduced Activity of CD13/Aminopeptidase N (APN) in Aggressive Meningiomas Is Associated with Increased Levels of SPARC.
Reduced growth, increased vascular area, and reduced response to cisplatin in CD13-overexpressing human ovarian cancer xenografts.
Regulation of aminopeptidase A in human brain tumor vasculature: evidence for a role of transforming growth factor-beta.
Renal Carcinoma Is Associated With Increased Risk of Coronavirus Infections.
Renal translocation carcinomas: clinicopathologic, immunohistochemical, and gene expression profiling analysis of 31 cases with a review of the literature.
Research Progress of Radiolabeled Asn-Gly-Arg (NGR) Peptides for Imaging and Therapy.
Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation.
Role of ubenimex as an anticancer drug and its synergistic effect with Akt inhibitor in human A375 and A2058 cells.
Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy.
Serum APN/CD13 as a novel diagnostic and prognostic biomarker of pancreatic cancer.
Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas.
Silver(I)/6-hydroxyiminolumazine compounds differently modify renin-angiotensin system-regulating aminopeptidases A and N in human neuroblastoma and glioma cells.
Soluble aminopeptidase N/CD13 in malignant and nonmalignant effusions and intratumoral fluid.
Solute carrier transporters as targets for drug delivery and pharmacological intervention for chemotherapy.
Studies on the mouse mammary tumour agent (MTA). II. Cytochemistry of aminopeptidase in normal mammary gland of C57BL, spontaneous and virus-induced mammary tumours in R3 and C57BL mouse strains, respectively, and in cell lines producing the mammary tumour virus.
Sucrase-isomaltase expression and enterocytic ultrastructure of human colorectal tumors.
Synthesis and 4D-QSAR Studies of Alanine Hydroxamic Acid Derivatives as Aminopeptidase N Inhibitors.
Synthesis and activity evaluation of a new bestatin derivative LYP2 as an aminopeptidase N inhibitor.
Synthesis and biological evaluation of novel flavone-8-acetic acid derivatives as reversible inhibitors of aminopeptidase N/CD13.
Synthesis and evaluation of novel Tc-99?m labeled NGR-containing hexapeptides as tumor imaging agents.
Synthesis and evaluation of novel Tc-99m labeled probestin conjugates for imaging APN/CD13 expression in vivo.
Synthesis and Molecular Simulation Studies of Mandelic Acid Peptidomimetic Derivatives as Aminopeptidase N Inhibitors.
Synthesis and molecular simulation study of furoic peptidomimetic derivatives as potent aminopeptodase N inhibitors.
Synthesis of 1,3,4-thiadiazole derivatives as aminopeptidase N inhibitors.
Synthesis of 5-(4'-carboxyphenyl)-10,15,20-tris-(4 pyridyl)-porphyrin and its peptidyl phosphonate derivatives.
Tamm Horsfall protein expression by a small renal cell carcinoma presenting with metastases.
Targeted antitumor prodrug therapy using CNGRC-yCD fusion protein in combination with 5-fluorocytosine.
Targeting aminopeptidase N (APN/CD13) with cyclic-imide peptidomimetics derivative CIP-13F inhibits the growth of human ovarian carcinoma cells.
Targeting inhibition of fibroblast activation protein-? and prolyl oligopeptidase activities on cells common to metastatic tumor microenvironments.
Targeting liposomal chemotherapy via both tumor cell-specific and tumor vasculature-specific ligands potentiates therapeutic efficacy.
Targeting non-human coronaviruses to human cancer cells using a bispecific single-chain antibody.
Targeting peptide functionalized liposomes towards aminopeptidase N for precise tumor diagnosis and therapy.
Targeting Tissue Factor to Tumor Vasculature to Induce Tumor Infarction.
The Aminopeptidase CD13 Induces Homotypic Aggregation in Neutrophils and Impairs Collagen Invasion.
The Analgesic Activity of Bestatin as a Potent APN Inhibitor.
The CNGRCLLII(KLAKLAK)2 peptide shows cytotoxicity against HUVECs by inducing apoptosis: An in vitro and in vivo study.
The effect of different species aminopeptidase N structure on the activity screening of aminopeptidase N inhibitor.
The effect of Mn2+ and Co2+ on the activities of a zinc metallodipeptidase from a mouse ascites tumor.
The enzymes of the hepatobiliary tract: a biochemical and clinical comparison.
The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review.
The main neutral aminopeptidase activity of human lymphoid tumour cell lines does not originate from the aminopeptidase N-(APN; CD13) gene.
The neovasculature homing motif NGR: more than meets the eye.
The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo.
The pro-oxidant buthionine sulfoximine (BSO) reduces tumor growth of implanted Lewis lung carcinoma in mice associated with increased protein carbonyl, tubulin abundance, and aminopeptidase activity.
The synthesis and preliminary activity assay in vitro of peptide-like derivatives as APN inhibitors.
Tissue-factor fusion proteins induce occlusion of tumor vessels.
Tumor Growth Inhibition via Occlusion of Tumor Vasculature Induced by N-Terminally PEGylated Retargeted Tissue Factor tTF-NGR.
Tumor vascular targeted liposomal-bortezomib minimizes side effects and increases therapeutic activity in human neuroblastoma.
Tumor vascular targeting with tumor necrosis factor alpha and chemotherapeutic drugs.
Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway.
XPNPEP2 is associated with lymph node metastasis in prostate cancer patients.
[Alanine aminopeptidase and gamma-glutamyltransferase in tumors of the human]
[Aldolase, dipeptidase, tripeptidase, tributyrinase, phosphatase, amylase, proteins and protein polysaccharides in the blood serum and ascites fluid in the mouse ascites tumor.]
[Cancer and aminopeptidase N]
[Cathepsin H activity in the human brain and human brain neoplasms]
[Comparative study on urinary parameters reflecting renal damage during chemotherapy for urological cancer]
[Detection of gene expression alteration of myeloma cells treated with arsenic trioxide]
[Do immunologic markers facilitate differentiation between histologic types of stomach cancer?]
[Enzyme cytochemical investigations on pleural effusions (author's transl)]
[Enzymological study of prostatic cancer. I. Changes of serum lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase, prostatic acid phosphatase, glutamic pyruvic transaminase, glutamic oxalacetic transaminase activity and lactic dehydrogenase isoenzymes in prostatic cancer under anti-androgenic treatment, with special reference to prognosis]
[Enzymological study of prostatic cancer. II. Serum lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase, prostatic acid phosphatase activity and lactic dehydrogenase isoenzymes in prostatic cancer, with special reference to relation with stage and histological malignancy]
[Growth promoting effect of IL-6 on medulloblastoma cells in vitro]
[Histochemical studies of human stomach biopsies with special reference to hydrolases]
[Inhibition of tumor cell invasion and induction of apoptosis by ubenimex].
[MnSOD gene regulated by aminopeptidase N promoter specifically protects bone marrow from radiation]
[On relations between aminopeptidase (LAP) and destructive tumor growth]
[The significance of serum leucine aminopeptidase (P-LAP) determination in the gynecological malignancies]
[Tumor markers in the cytodiagnosis of thyroid nodules. Detection of dipeptidyl aminopeptidase IV (DAP IV) activity]
[Urological neoplasms and enzyme. IV. Studies on the alteration of lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, and total acid phosphatase activities and LDH isozymes in experimentally induced renal tumors with dimethylnitrosamine]
[Urological neoplasms and enzymes. V. Studies on the alteration of lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase activities and LDH isozymes in experimentally induced renal tumors with lead acetate]
Nephritis
A fluorometric method for dipeptidase activity measurement in urine, using L-alanyl-L-alanine as substrate.
Urinary alanine aminopeptidase activity in various urinary tract diseases.
Nephroma, Mesoblastic
In vivo assessment of aminopeptidase N (APN/CD13) specificity of different 68Ga-labelled NGR derivatives using PET/MRI imaging.
Nephrosclerosis
Urinary Lysosomal Enzyme Activities and Albuminuria in Ghanaian Patients with Type 2 Diabetes Mellitus.
Nephrotic Syndrome
Urinary trehalase activity in chronic glomerulonephritis.
[A method of separate determination of enzymuria associated with impairment of glomerular filtration in kidney tissue]
[Activity of alanine aminopeptidase, beta-glucuronidase and N-acetyl-beta-d-glucosaminidase in urine of children with nephrotic syndrome]
Neuralgia
Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain.
Neuroblastoma
Characterization of the enkephalin-degrading aminopeptidase of neuroblastoma (N1E-115) cell membranes.
Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma.
Differential Effects of Doxazosin on Renin-Angiotensin-System-Regulating Aminopeptidase Activities in Neuroblastoma and Glioma Tumoral Cells.
Enkephalin degradation by enkephalinergic neuroblastoma cells. Involvement of angiotensin-converting-enzyme.
Targeting liposomal chemotherapy via both tumor cell-specific and tumor vasculature-specific ligands potentiates therapeutic efficacy.
Vascular damage and anti-angiogenic effects of tumor vessel-targeted liposomal chemotherapy.
Neuronal Ceroid-Lipofuscinoses
Functional consequences and rescue potential of pathogenic missense mutations in tripeptidyl peptidase I.
Tripeptidyl-peptidase I in neuronal ceroid lipofuscinoses and other lysosomal storage disorders.
Non-alcoholic Fatty Liver Disease
Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease.
[Serum dipeptidyl peptidase N levels in obese children with nonalcoholic fatty liver disease].
Obesity
Klotho and Aminopeptidases as Early Biomarkers of Renal Injury in Zucker Obese Rats.
[Obesity, inflammation and insulin resistance: role of gp 130 receptor ligands]
Obstetric Labor, Premature
Placental leucine aminopeptidase- and aminopeptidase A- deficient mice offer insight concerning the mechanisms underlying preterm labor and preeclampsia.
Oligohydramnios
Effects of exposure to tobacco smoke in pregnancies complicted by oligohydramnios and premature rupture of the membranes. II. Activity of brush border enzymes in human amniotic fluid.
Opisthorchiasis
Partial protection with a chimeric tetraspanin-leucine aminopeptidase subunit vaccine against Opisthorchis viverrini infection in hamsters.
Osteoarthritis
CD13/aminopeptidase N in collagen vascular diseases.
Osteoporosis
Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes.
Osteosarcoma
Enhancement of methotrexate nephrotoxicity after cisplatin therapy.
Inhibitory effect of antisense aminopeptidase N (APN/CD13) cDNA transfection on the invasive potential of osteosarcoma cells.
Possible contribution of aminopeptidase N (APN/CD13) to invasive potential enhanced by interleukin-6 and soluble interleukin-6 receptor in human osteosarcoma cell lines.
Possible contribution of aminopeptidase N (APN/CD13) to migration and invasion of human osteosarcoma cell lines.
Ototoxicity
Pharmacokinetic and toxicity evaluation of five-day continuous infusion versus intermittent bolus cis-diamminedichloroplatinum(II) in head and neck cancer patients.
Ovarian Neoplasms
Distinguishing primary from secondary mucinous ovarian tumors: an algorithm using the novel marker DPEP1.
Expression of aminopeptidase N/CD13 in human ovarian cancers.
Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with anti-proliferative aminopeptidase inhibitors.
Pancreatic Cyst
The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts.
Pancreatic Diseases
[Critical studies on the diagnostic significance of alanine aminopeptidase and its isoenzymes in pancreatic diseases]
[Isoenzymes of alanine aminopeptidase as specific parameters in the diagnosis of biliary and pancreatic diseases]
Pancreatic Neoplasms
A clinical evaluation of serological diagnosis for pancreatic cancer.
Phase Ib/II study combining tosedostat with capecitabine in patients with advanced pancreatic adenocarcinoma.
Serum APN/CD13 as a novel diagnostic and prognostic biomarker of pancreatic cancer.
[Isoenzymes of alanine arylamidase (AAP, EC 3.4.11.2) and gamma-glutamyltranspeptidase (GGTP, EC 2.3.2.2) in chronic pancreatitis and pancreas neoplasm (author's transl)]
Pancreatitis
Serum pyroglutamyl aminopeptidase activity: a promising novel biomarker candidate for liver cirrhosis.
Pancreatitis, Chronic
Serum APN/CD13 as a novel diagnostic and prognostic biomarker of pancreatic cancer.
[Isoenzymes of alanine arylamidase (AAP, EC 3.4.11.2) and gamma-glutamyltranspeptidase (GGTP, EC 2.3.2.2) in chronic pancreatitis and pancreas neoplasm (author's transl)]
Papilloma
Expression of the COVID-19 receptor ACE2 in the human conjunctiva.
Paralysis
The Drosophila slamdance gene: a mutation in an aminopeptidase can cause seizure, paralysis and neuronal failure.
Parasitic Diseases
Induction of some digestive enzymes in the midgut of the sandfly Phlebotomus langeroni after sugar and blood meals.
Parkinson Disease
Plasma aminopeptidase activities in Parkinson's disease.
The Human Coronavirus Receptor ANPEP (CD13) Is Overexpressed in Parkinson's Disease.
Pemphigus
[Histotopography of aminopeptidase in pemphigus vulgaris; with a contribution to the pathogenesis of acantholytic blister formation.]
Periodontal Diseases
Alanine aminopeptidase and dipeptidylpeptidase IV in saliva: the possible role in periodontal disease.
An aminopeptidase nutritionally important to Fusobacterium nucleatum.
Serum levels of oncostatin M (a gp 130 cytokine): an inflammatory biomarker in periodontal disease.
Periodontitis
Salivary proteolytic activities in periodontitis, gingivitis and diabetes mellitus.
Peritonitis
Analysis of the mechanism of antibody-dependent enhancement of feline infectious peritonitis virus infection: aminopeptidase N is not important and a process of acidification of the endosome is necessary.
Characterization of determinants involved in the feline infectious peritonitis virus receptor function of feline aminopeptidase N.
Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus.
Interspecies aminopeptidase-N chimeras reveal species-specific receptor recognition by canine coronavirus, feline infectious peritonitis virus, and transmissible gastroenteritis virus.
Intriguing interplay between feline infectious peritonitis virus and its receptors during entry in primary feline monocytes.
Targeting non-human coronaviruses to human cancer cells using a bispecific single-chain antibody.
TNF-alpha, produced by feline infectious peritonitis virus (FIPV)-infected macrophages, upregulates expression of type II FIPV receptor feline aminopeptidase N in feline macrophages.
Pituitary Neoplasms
Expression of interleukin-6, interleukin-6 receptor (gp80), and the receptor's signal-transducing subunit (gp130) in human normal pituitary glands and pituitary adenomas.
Pleural Effusion
CD13/aminopeptidase N in collagen vascular diseases.
Pneumonia
Structural and kinetic bases for the metal preference of the M18 aminopeptidase from Pseudomonas aeruginosa.
The significance of cathepsins, thrombin and aminopeptidase in diffuse interstitial lung diseases.
Pneumonia, Progressive Interstitial, of Sheep
Expression of the gp150 maedi visna virus envelope precursor protein by mammalian expression vectors.
Polycystic Kidney, Autosomal Dominant
Chymase-like angiotensin II-generating activity in end-stage human autosomal dominant polycystic kidney disease.
Polyuria
Reversibility of renal tubular dysfunction in streptozotocin-induced diabetes in the rat.
Pre-Eclampsia
Aminopeptidase A (ENPEP) gene polymorphisms and preeclampsia: Descriptive analysis.
Increased tubular enzyme excretion in preeclampsia.
Physiological and pathophysiological roles of placental aminopeptidase in maternal sera: possible relation to preeclampsia and preterm delivery.
Placental leucine aminopeptidase- and aminopeptidase A- deficient mice offer insight concerning the mechanisms underlying preterm labor and preeclampsia.
Relationship between the changes in placental blood flow resistance assessed by Doppler technique and maternal serum placental aminopeptidases, which degrade vaso-active peptides, in pre-eclampsia.
The role of LNPEP and ANPEP gene polymorphisms in the pathogenesis of pre-eclampsia.
Primary Immunodeficiency Diseases
Flavivirus Antagonism of Type I Interferon Signaling Reveals Prolidase as a Regulator of IFNAR1 Surface Expression.
Prostatic Hyperplasia
[Enzymatic activities in human prostatic adenoma (leucine aminopeptidase, 5-nucleotidase, adenosine triphosphatase, lactic dehydrogenase, phosphohexoisomerase).]
Prostatic Neoplasms
11C-MCG: synthesis, uptake selectivity, and primate PET of a probe for glutamate carboxypeptidase II (NAALADase).
Angiotensin II and its fragments (angiotensins III and IV) decrease the growth of DU-145 prostate cancer in vitro.
Incadronate inhibits aminopeptidase N expression in prostatic PC-3 cells.
Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer.
Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast.
Prognostic significance of aberrantly silenced ANPEP expression in prostate cancer.
[Comparative study on urinary parameters reflecting renal damage during chemotherapy for urological cancer]
[Enzymological study of prostatic cancer. I. Changes of serum lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase, prostatic acid phosphatase, glutamic pyruvic transaminase, glutamic oxalacetic transaminase activity and lactic dehydrogenase isoenzymes in prostatic cancer under anti-androgenic treatment, with special reference to prognosis]
[Enzymological study of prostatic cancer. II. Serum lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase, prostatic acid phosphatase activity and lactic dehydrogenase isoenzymes in prostatic cancer, with special reference to relation with stage and histological malignancy]
[Enzymological study of prostatic cancer. V. Alterations in the serum acid and alkaline phosphatase and leucine aminopeptidase activities following massage of the prostate]
Proteinuria
Cancer chemotherapy-induced tubular nephrotoxicity evaluated by immunochemical determination of urinary adenosine deaminase binding protein.
Cisplatin nephrotoxicity and protection by silibinin.
Neomycin toxicosis in calves.
Tubulopathy with macroalbuminuria due to diabetic nephropathy and primary glomerulonephritis.
Urinary excretion of alanine aminopeptidase and total proteinuria in experimental diabetes mellitus before and after islet transplantation.
Vancomycin does not enhance amikacin-induced tubular nephrotoxicity in children.
Psoriasis
APN/CD13 is over-expressed by Psoriatic fibroblasts and is modulated by CGRP and IL-4 but not by retinoic acid treatment.
Functional Genomics and Its Bench-to-Bedside Translation Pertaining to the Identified Susceptibility Alleles and Loci in Ankylosing Spondylitis.
[Histochemical determination of aminopeptidase in normal skin, psoriasis, dermatitis, basaloma, spinous cell carcinoma and molluscum sebaceum.]
Pulmonary Disease, Chronic Obstructive
A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.
Development and Clinical Validation of a Novel 4-Gene Prognostic Signature Predicting Survival in Colorectal Cancer.
Effect of Modifier Structure on the Activation of Leukotriene A4 Hydrolase Aminopeptidase Activity.
Pulmonary Emphysema
Effect of the leukotriene A4 hydrolase aminopeptidase augmentor 4-methoxydiphenylmethane in a pre-clinical model of pulmonary emphysema.
Pulmonary Eosinophilia
The significance of cathepsins, thrombin and aminopeptidase in diffuse interstitial lung diseases.
Pulmonary Heart Disease
[Urinary alanine aminopeptidase and lysozyme excretion in patients with diabetes]
Pyelonephritis
Efficacy and safety of once daily versus intermittent dosing of tobramycin in rabbits with acute pyelonephritis.
Urinary alanine aminopeptidase activity in various urinary tract diseases.
[Excretion of alanine aminopeptidase in the urine after administration of lysosomotrophic substances in patients with latent or florid pyelonephritis]
[Renal dipeptidylpeptidase IV excretion in drug-induced kidney changes]
Renal Insufficiency
A low molecular weight alanine aminopeptidase in urine. Biochemical equivalent of tubular atrophy?
Alanine aminopeptidase excretion after mercuric chloride renal failure.
Aminopeptidase activity in the livers of rats with experimental chronic renal failure.
Evaluation of urinary enzymes in dogs with early renal disorder.
Renal Insufficiency, Chronic
Diagnostic significance of different urinary enzymes in patients suffering from chronic renal diseases.
Rhabdomyolysis
Lipoic acid effects on renal function, aminopeptidase activities and oxidative stress in Crotalus durissus terrificus envenomation in mice.
Rhabdomyosarcoma
Cell cycle phases of two human lung tumor cell lines derived from squamous cell carcinoma and pulmonary metastasis of a rhabdomyosarcoma (HS 24 and HS 57) and N-acetylalanine aminopeptidase activity.
Sarcoidosis
CD13/aminopeptidase N, a novel chemoattractant for T lymphocytes in pulmonary sarcoidosis.
Sarcoidosis, Pulmonary
CD13/aminopeptidase N, a novel chemoattractant for T lymphocytes in pulmonary sarcoidosis.
Sarcoma
Aminopeptidase N (CD13): Expression, Prognostic Impact, and Use as Therapeutic Target for Tissue Factor Induced Tumor Vascular Infarction in Soft Tissue Sarcoma.
Identification of APN/CD13 as the target antigen of FU3, a human monoclonal antibody that recognizes malignant fibrous histiocytoma.
Schistosomiasis
Antigenic properties of Schistosoma mansoni aminopeptidases: evolution during the development in mammalian hosts.
Scleroderma, Systemic
CD13/aminopeptidase N in collagen vascular diseases.
Seizures
The Drosophila slamdance gene: a mutation in an aminopeptidase can cause seizure, paralysis and neuronal failure.
Severe Acute Respiratory Syndrome
Renin-angiotensin system inhibition and risk of infection and mortality in COVID-19: a systematic review and meta-analysis.
Shock, Cardiogenic
Circulating plasma dipeptidyl dipeptidase 3 and the prognosis of cardiogenic shock.
Shock, Septic
Leucyl/cystinyl aminopeptidase (LNPEP) gene variants in septic shock.
Silicosis
[Kinin aminopeptidase in lung tissue and activity of kininase II in the serum of patients with silicosis]
Sjogren's Syndrome
[Activity of the esterase, alkaline phosphatase and aminopeptidase in the gastric mucosa in patients with Sjogren syndrome.]
Skin Diseases
The ectopeptidases dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN) and their related enzymes as possible targets in the treatment of skin diseases.
Skin Diseases, Vesiculobullous
Histochemical study of bullous dermatoses. II. Leucine aminopeptidase.
Spinal Dysraphism
Fetal anal incontinence evaluated by amniotic fluid digestive enzyme assay in myelomeningocele spina bifida.
Spondylitis, Ankylosing
ERAP1 and ankylosing spondylitis.
Expression of MHC class I dimers and ERAP1 in an ankylosing spondylitis patient cohort.
Squamous Cell Carcinoma of Head and Neck
Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinoma.
Starvation
Adaptation of intestinal enzymes to seasonal and dietary changes in a hibernator: the European hamster (Cricetus cricetus).
Adaptation of intestinal hydrolases to starvation in rats: effect of thyroid function.
Alterations in the DNA binding activity of transcriptional factors activator protein-1, Sp1, and hepatocyte nuclear factor-1 in rat jejunum during starvation and refeeding.
Deletion analysis of the promoter region of the Escherichia coli pepN gene, a gene subject in vivo to multiple global controls.
Dietary whey proteins and their peptides or amino acids: effects on the jejunal mucosa of starved rats.
Effect of early postnatal long-term fasting on the development of peptide hydrolysis in chicks.
Effect of fasting on the structure and function of the gastrointestinal tract of house sparrows (Passer domesticus).
Evidence for a potential common T-cell epitope between human thyroid peroxidase and human thyroglobulin with implications for the pathogenesis of autoimmune thyroid disease.
Modifications of brush border enzyme activities during starvation in the jejunum and ileum of adult rats.
PtdIns4P restriction by hydrolase SAC1 decides specific fusion of autophagosomes with lysosomes.
The cellular location of proteases in Candida albicans.
Stomach Neoplasms
Aminopeptidase N (APN/CD13) as a target molecule for scirrhous gastric cancer.
Aminopeptidases and arylamidases in normal and cancer tissues in humans.
Clinicopathological significance of aminopeptidase N/CD13 expression in human gastric carcinoma.
Stomatitis, Denture
Activity of arginine aminopeptidases and phosphatases in inflamed palatal mucosa in denture stomatitis: a histochemical and biochemical study.
Stroke
Bioinformatics Gene Analysis of Potential Biomarkers and Therapeutic Targets for Unstable Atherosclerotic Plaque-Related Stroke.
Testicular Neoplasms
Urinary excretion of alanine-aminopeptidase and N-acetyl-beta-D-glucosaminidase during sequential combination chemotherapy.
Tetanus
Evidence for a link between specific proteolysis and inhibition of [3H]-noradrenaline release by the light chain of tetanus toxin.
Families of zinc metalloproteases.
Thromboembolism
Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism.
Thrombosis
Infarction of tumor vessels by NGR-peptide-directed targeting of tissue factor: experimental results and first-in-man experience.
Thymoma
Characterization of the neutral aminopeptidase activity associated to the mouse thymocyte-activating molecule.
Murine thymocytes possess specific cell surface-associated exoaminopeptidase activities: preferential expression by immature CD4-CD8- subpopulation.
Thyroid Carcinoma, Anaplastic
Biological significance of aminopeptidase N/CD13 in thyroid carcinomas.
Thyroid Neoplasms
Biological significance of aminopeptidase N/CD13 in thyroid carcinomas.
Decrease in Dipeptidyl Peptidase IV Activity is Linked to the Efficacy of Differentiating Compounds in Follicular Thyroid Carcinoma Cell Lines.
Diagnostic evaluation of alanine aminopeptidase as serum marker for detecting cancer.
Thyroid Nodule
[Tumor markers in the cytodiagnosis of thyroid nodules. Detection of dipeptidyl aminopeptidase IV (DAP IV) activity]
Toxoplasmosis
Aminopeptidase activity in the brains of mice with chronic Toxoplasma gondii infections.
Toxoplasmosis, Congenital
Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans.
Trichinellosis
Molecular characterization of Trichinella spiralis aminopeptidase and its potential as a novel vaccine candidate antigen against trichinellosis in BALB/c mice.
Tuberculosis
Aminopeptidase N Facilitates Entry and Intracellular Survival of Mycobacterium Tuberculosis in Monocytes.
Characterization and comparison of aminopeptidase activity of various strains of Mycobacterium tuberculosis.
Mycobacterium tuberculosis puromycin hydrolase displays a prolyl oligopeptidase fold and an acyl aminopeptidase activity.
The Activity of a Hexameric M17 Metallo-Aminopeptidase Is Associated With Survival of Mycobacterium tuberculosis.
Transposition of IS117 of Streptomyces coelicolor A3(2) in Mycobacterium smegmatis.
Urinary Bladder Neoplasms
Aminopeptidase activities as prospective urinary biomarkers for bladder cancer.
[Activity of aminopeptidase in blood and urine in patients with bladder neoplasms]
[Enzymological study of bladder tumor. I. Serum lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase, prostatic acid phosphatase, glutamic pyruvic transaminase, glutamic oxalacetic transaminase activities and LDH isoenzymes: the relations with stage and histological grade]
[Mechanisms for effect of osthole on inhibiting the growth and invasion of bladder cancer cells].
Urinary Tract Infections
Diagnostic potential of urinary enzymes and beta 2-microglobulin in acute urinary tract infection.
Urologic Diseases
Urinary alanine aminopeptidase activity in various urinary tract diseases.
[Clinical evaluation of urinary glycyl-prolyl dipeptidyl aminopeptidase in patients with urological disease]
Urologic Neoplasms
Inhibition of aminopeptidase N (AP-N) and urokinase-type plasminogen activator (uPA) by zinc suppresses the invasion activity in human urological cancer cells.
[Urological neoplasms and enzyme. IV. Studies on the alteration of lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, and total acid phosphatase activities and LDH isozymes in experimentally induced renal tumors with dimethylnitrosamine]
[Urological neoplasms and enzymes. V. Studies on the alteration of lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase activities and LDH isozymes in experimentally induced renal tumors with lead acetate]
Uterine Cervical Neoplasms
Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer.
Vaccinia
Envelope-Specific Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence.
Immunogenicity of HIV-1 Vaccines Expressing Chimeric Envelope Glycoproteins on the Surface of Pr55 Gag Virus-Like Particles.
Murine gamma-herpesvirus 68 glycoprotein 150 protects against virus-induced mononucleosis: a model system for gamma-herpesvirus vaccination.
Subtype C gp140 Vaccine Boosts Immune Responses Primed by the South African AIDS Vaccine Initiative DNA-C2 and MVA-C HIV Vaccines after More than a 2-Year Gap.
Vesicular Stomatitis
A novel type of detergent-resistant membranes may contribute to an early protein sorting event in epithelial cells.
Viremia
Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism.
Virus Diseases
Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection.
Aminopeptidase N Knockout Pigs Are Not Resistant to Porcine Epidemic Diarrhea Virus Infection.
Aminopeptidase secreted by Chromobacterium sp. Panama inhibits dengue virus infection by degrading the E protein.
Analysis of the mechanism of antibody-dependent enhancement of feline infectious peritonitis virus infection: aminopeptidase N is not important and a process of acidification of the endosome is necessary.
Contribution of the porcine aminopeptidase N (CD13) receptor density to porcine epidemic diarrhea virus infection.
Human aminopeptidase N is a receptor for human coronavirus 229E.
Metalloprotease ADAM17 regulates porcine epidemic diarrhea virus infection by modifying aminopeptidase N.
Time-dependent viral interference between influenza virus and coronavirus in the infection of differentiated porcine airway epithelial cells.
Visna
Expression of the gp150 maedi visna virus envelope precursor protein by mammalian expression vectors.
Visna/maedi virus Env protein expressed by a vaccinia virus recombinant induces cell-to-cell fusion in cells of different origins in the apparent absence of Env cleavage: role of glycosylation and of proteoglycans.