Reference on EC 3.4.11.18 - methionyl aminopeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bazan, J.F.; Weaver, L.H.; Roderick, S.L.; Huber, R.; Matthews, B.W.
Sequence and structure comparison suggests that methionine aminopeptidase, prolidase, aminopeptidase P, and creatinase share a common fold
Proc. Natl. Acad. Sci. USA
91
2473-2477
1994
Escherichia coli
Roderick, S.L.; Matthews, B.W.
Crystallization of methionine aminopeptidase from Escherichia coli
J. Biol. Chem.
263
16531
1988
Escherichia coli
Ben-Bassat, A.; Bauer, K.; Chang, S.Y.; Myambo, K.; Boosman, A.; Chang, S.
Processing of the initiation methionine from proteins: properties of the Escherichia coli methionine aminopeptidase and its gene structure
J. Bacteriol.
169
751-757
1987
Escherichia coli
Yoshida, A.; Lin, M.
NH2 -terminal formylmethionine- and NH2 -terminal methionine-cleaving enzymes in rabbits
J. Biol. Chem.
247
952-957
1972
Oryctolagus cuniculus
Tsunasawa, S.; Stewart, J.W.; Sherman, F.
Amino-terminal processing of mutant forms of yeast iso-1-cytochrome c. The specificities of methionine aminopeptidase and acetyltransferase
J. Biol. Chem.
260
5382-5391
1985
Saccharomyces cerevisiae
Kendall, R.L.; Bradshaw, R.A.
Isolation and characterization of the methionine aminopeptidase from porcine liver responsible for the co-translational processing of proteins
J. Biol. Chem.
267
20667-20673
1992
Sus scrofa
Chang, Y.H.; Teichert, U.; Smith, J.A.
Molecular cloning, sequencing, deletion, and overexpression of a methionine aminopeptidase gene from Saccharomyces cerevisiae
J. Biol. Chem.
267
8007-8011
1992
Saccharomyces cerevisiae
Chang, Y.H.; Teichert, U.; Smith, J.A.
Purification and characterization of a methionine aminopeptidase from Saccharomyces cerevisiae
J. Biol. Chem.
265
19892-19897
1990
Saccharomyces cerevisiae
Wingfield, P.; Graber, P.; Turcatti, G.; Movva, N.R.; Pelletier, M.; Craig, S.; Rose, K.; Miller, C.G.
Purification and characterization of a methionine-specific aminopeptidase from Salmonella typhimurium
Eur. J. Biochem.
180
23-32
1989
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium TN2529
Termignoni, C.; Freitas, J.O.; Guimaraes, J.A.
Removal of N-terminal methionine from haemoglobin nascent peptides by a membrane-bound rat liver methionine aminopeptidase
Biochem. J.
234
469-473
1986
Rattus norvegicus
Arfin, S.M.; Kendall, R.L.; Hall, L.; Weaver, L.H.; Stewart, A.E.; Matthews, B.W.; Bradshaw, R.A.
Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes
Proc. Natl. Acad. Sci. USA
92
7714-7718
1995
Escherichia coli, Homo sapiens, Sus scrofa
Zuo, S.; Guo, Q.; Ling, C.; Chang, Y.H.
Evidence that two zinc fingers in the methionine aminopeptidase from Saccharomyces cerevisiae are important for normal growth
Mol. Gen. Genet.
246
247-253
1995
Saccharomyces cerevisiae
Roderick, S.L.; Matthews, B.W.
Structure of the cobalt-dependent methionine aminopeptidase from Escherichia coli: a new type of proteolytic enzyme
Biochemistry
32
3907-3912
1993
Escherichia coli
Freitas, J.O.; Termignoni, C.; Guimaraes, J.A.
Microsomal methionine aminopeptidase: properties of the detergent-solubilized enzyme
Int. J. Biochem.
17
1285-1291
1985
Rattus norvegicus
Freitas, J.O.; Termignoni, C.; Borges, D.R.; Sampaio, C.A.M.; Prado, J.L.; Guimaraes, J.A.
Methionine aminopeptidase associated with liver mitochondria and microsomes
Int. J. Biochem.
13
991-997
1981
Rattus norvegicus
Yang, G.; Kirkpatrick, R.B.; Ho, T.; Zhang, G.F.; Liang, P.H.; Johanson, K.O.; Casper, D.J.; Doyle, M.L.; Marino, J.P., Jr.; Thompson, S.K.; Chen, W.; Tew, D.G.; Meek, T.D.
Steady-State Kinetic Characterization of Substrates and Metal-Ion Specificities of the Full-Length and N-Terminally Truncated Recombinant Human Methionine Aminopeptidases (Type 2)
Biochemistry
40
10645-10654
2001
Homo sapiens
D'Souza, V.M.; Bennett, B.; Copik, A.J.; Holz, R.C.
Divalent Metal Binding Properties of the Methionyl Aminopeptidase from Escherichia coli
Biochemistry
39
3817-3826
2000
Escherichia coli
Klinkenberg, M.; Ling, C.; Chang, Y.H.
A dominant negative mutation in Saccharomyces cerevisiae methionine aminopeptidase-1 affects catalysis and interferes with the function of methionine aminopeptidase-2
Arch. Biochem. Biophys.
347
193-200
1997
Saccharomyces cerevisiae
Tahirov, T.H.; Oki, H.; Tsukihara, T.; Ogasahara, K.; Yutani, K.; Ogata, K.; Izu, Y.; Tsunasawa, S.; Kato, I.
Crystal structure of methionine aminopeptidase from hyperthermophile, Pyrococcus furiosus
J. Mol. Biol.
284
101-124
1998
Pyrococcus furiosus
Son, K.H.; Kwon, J.Y.; Jeong, H.W.; Kim, H.K.; Kim, C.J.; Chang, Y.H.; Choi, J.D.; Kwon, B.M.
5-demethylovalicin, as a methionine aminopeptidase-2 inhibitor produced by Chrysosporium
Bioorg. Med. Chem.
10
185-188
2002
Homo sapiens
D'Souza, V.M.; Holz, R.C.
The Methionyl aminopeptidase from Escherichia coli can function as an iron(II) enzyme
Biochemistry
38
11079-11085
1999
Escherichia coli
Liu, S.; Widom, J.; Kemp, C.W.; Crews, C.M.; Clardy, J.
Structure of human methionine aminopeptidase-2 complexed with fumagillin
Science
282
1324-1327
1998
Homo sapiens (P50579), Homo sapiens
Larrabee, J.A.; Thamrong-Nawasawat, T.; Yee Mon, S.
High-pressure liquid chromatographic method for the assay of methionine aminopeptidase activity: application to the study of enzymic inactivation
Anal. Biochem.
269
194-198
1999
Escherichia coli
Lowther, W.T.; McMillen, D.A.; Orville, A.M.; Matthews, B.W.
The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase
Proc. Natl. Acad. Sci. USA
95
12153-12157
1998
Escherichia coli
Oefner, C.; Douangamath, A.; D'Arcy, A.; Hafeli, S.; Mareque, D.; MacSweeney, A.; Padilla, J.; Pierau, S.; Schulz, H.; Thormann, M.; Wadman, S.; Dale, G.E.
The 1.15.ANG. crystal structure of the Staphylococcus aureus methionyl-aminopeptidase and complexes with triazole based inhibitors
J. Mol. Biol.
332
13-21
2003
Staphylococcus aureus
Li, J.Y.; Chen, L.L.; Cui, Y.M.; Luo, Q.L.; Li, J.; Nan, F.J.; Ye, Q.Z.
Specificity for inhibitors of metal-substituted methionine aminopeptidase
Biochem. Biophys. Res. Commun.
307
172-179
2003
Escherichia coli
Chung, J.M.; Chung, I.Y.; Lee, Y.S.
The purification and characterization of a Bacillus stearothermophilus methionine aminopeptidase (MetAP)
J. Biochem. Mol. Biol.
35
228-235
2002
Geobacillus stearothermophilus
Klein, C.D.; Schiffmann, R.; Folkers, G.; Piana, S.; Rothlisberger, U.
Protonation states of methionine aminopeptidase and their relevance for inhibitor binding and catalytic activity
J. Biol. Chem.
278
47862-47867
2003
Escherichia coli (P0AE18)
Vetro, J.A.; Chang, Y.H.
Yeast methionine aminopeptidase type 1 is ribosome-associated and requires its N-terminal zinc finger domain for normal function in vivo
J. Cell. Biochem.
85
678-688
2002
Saccharomyces cerevisiae
Luo, Q.L.; Li, J.Y.; Liu, Z.Y.; Chen, L.L.; Li, J.; Qian, Z.; Shen, Q.; Li, Y.; Lushington, G.H.; Ye, Q.Z.; Nan, F.J.
Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cerevisiae
J. Med. Chem.
46
2631-2640
2003
Saccharomyces cerevisiae, Escherichia coli
Walker, K.W.; Bradshaw, R.A.
Yeast methionine aminopeptidase I. Alteration of substrate specificity by site-directed mutagenesis
J. Biol. Chem.
274
13403-13409
1999
Saccharomyces cerevisiae
Chiu, C.H.; Lee, C.Z.; Lin, K.S.; Tam, M.F.; Lin, L.Y.
Amino acid residues involved in the functional integrity of Escherichia coli methionine aminopeptidase
J. Bacteriol.
181
4686-4689
1999
Escherichia coli
Walker, K.W.; Yi, E.; Bradshaw, R.A.
Yeast (Saccharomyces cerevisiae) methionine aminopeptidase I: rapid purification and improved activity assay
Biotechnol. Appl. Biochem.
29
157-163
1999
Saccharomyces cerevisiae
Copik, A.J.; Swierczek, S.I.; Lowther, W.T.; D'Souza, V.M.; Matthews, B.W.; Holz, R.C.
Kinetic and spectroscopic characterization of the H178A methionyl aminopeptidase from Escherichia coli
Biochemistry
42
6283-6292
2003
Escherichia coli
Wang, J.; Sheppard, G.S.; Lou, P.; Kawai, M.; Park, C.; Egan, D.A.; Schneider, A.; Bouska, J.; Lesniewski, R.; Henkin, J.
Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese
Biochemistry
42
5035-5042
2003
Homo sapiens
Selvakumar, P.; Lakshmikuttyamma, A.; Lawman, Z.; Bonham, K.; Dimmock, J.R.; Sharma, R.K.
Expression of methionine aminopeptidase 2,N-myristoyltransferase, and N-myristoyltransferase inhibitor protein 71 in HT29
Biochem. Biophys. Res. Commun.
322
1012-1017
2004
Homo sapiens
Chen, L.L.; Li, J.; Li, J.Y.; Luo, Q.L.; Mao, W.F.; Shen, Q.; Nan, F.J.; Ye, Q.Z.
Type I methionine aminopeptidase from Saccharomyces cerevisiae is a potential target for antifungal drug screening
Acta Pharmacol. Sin.
25
907-914
2004
Saccharomyces cerevisiae
Liu, L.F.; Hsieh, C.H.; Liu, P.F.; Tsai, S.P.; Tam, M.F.
Escherichia coli methionine aminopeptidase with Tyr168 to alanine substitution can improve the N-terminal processing of recombinant proteins with valine at the penultimate position
Anal. Biochem.
329
345-347
2004
Escherichia coli
Huang, M.; Xie, S.X.; Ma, Z.Q.; Hanzlik, R.P.; Ye, Q.Z.
Metal mediated inhibition of methionine aminopeptidase by quinolinyl sulfonamides
Biochem. Biophys. Res. Commun.
339
506-513
2006
Escherichia coli (P0AE18), Escherichia coli
Li, J.Y.; Chen, L.L.; Cui, Y.M.; Luo, Q.L.; Gu, M.; Nan, F.J.; Ye, Q.Z.
Characterization of full length and truncated type I human methionine aminopeptidases expressed from Escherichia coli
Biochemistry
43
7892-7898
2004
Homo sapiens
Copik, A.J.; Nocek, B.P.; Swierczek, S.I.; Ruebush, S.; Jang, S.B.; Meng, L.; D'Souza V.M.; Peters, J.W.; Bennett, B.; Holz, R.C.
EPR and X-ray crystallographic characterization of the product-bound form of the MnII-loaded methionyl aminopeptidase from Pyrococcus furiosus
Biochemistry
44
121-129
2005
Pyrococcus furiosus (P56218), Pyrococcus furiosus
Addlagatta, A.; Hu, X.; Liu, J.O.; Matthews, B.W.
Structural basis for the functional differences between type I and type II human methionine aminopeptidases
Biochemistry
44
14741-14749
2005
Homo sapiens
Addlagatta, A.; Quillin, M.L.; Omotoso, O.; Liu, J.O.; Matthews, B.W.
Identification of an SH3-binding motif in a new class of methionine aminopeptidases from Mycobacterium tuberculosis suggests a mode of interaction with the ribosome
Biochemistry
44
7166-7174
2005
Mycobacterium tuberculosis (P9WK19), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WK19)
You, C.; Lu, H.; Sekowska, A.; Fang, G.; Wang, Y.; Gilles, A.M.; Danchin, A.
The two authentic methionine aminopeptidase genes are differentially expressed in Bacillus subtilis
BMC Microbiol.
5
57
2005
Bacillus subtilis
Selvakumar, P.; Lakshmikuttyamma, A.; Kanthan, R.; Kanthan, S.C.; Dimmock, J.R.; Sharma, R.K.
High expression of methionine aminopeptidase 2 in human colorectal adenocarcinomas
Clin. Cancer Res.
10
2771-2775
2004
Homo sapiens
Morowitz, M.J.; Barr, R.; Wang, Q.; King, R.; Rhodin, N.; Pawel, B.; Zhao, H.; Erickson, S.A.; Sheppard, G.S.; Wang, J.; Maris, J.M.; Shusterman, S.
Methionine aminopeptidase 2 inhibition is an effective treatment strategy for neuroblastoma in preclinical models
Clin. Cancer Res.
11
2680-2685
2005
Homo sapiens
Cooper, A.C.; Karp, R.M.; Clark, E.J.; Taghizadeh, N.R.; Hoyt, J.G.; Labenski, M.T.; Murray, M.J.; Hannig, G.; Westlin, W.F.; Thompson, C.D.
A novel methionine aminopeptidase-2 inhibitor, PPI-2458, inhibits non-Hodgkin's lymphoma cell proliferation in vitro and in vivo
Clin. Cancer Res.
12
2583-2590
2006
Homo sapiens, Homo sapiens (P50579)
Zhang, H.; Huang, H.; Cali, A.; Takvorian, P.M.; Feng, X.; Zhou, G.; Weiss, L.M.
Investigations into microsporidian methionine aminopeptidase type 2: a therapeutic target for microsporidiosis
Folia Parasitol.
52
182-192
2005
Encephalitozoon cuniculi (Q8SR45), Encephalitozoon cuniculi, Encephalitozoon hellem (Q6XMH6), Encephalitozoon hellem, Encephalitozoon intestinalis (Q6XMH7), Encephalitozoon intestinalis
Copik, A.J.; Waterson, S.; Swierczek, S.I.; Bennett, B.; Holz, R.C.
Both nucleophile and substrate bind to the catalytic Fe(II)-center in the type-II methionyl aminopeptidase from Pyrococcus furiosus
Inorg. Chem.
44
1160-1162
2005
Pyrococcus furiosus
Larrabee, J.A.; Leung, C.H.; Moore, R.L.; Thamrong-nawasawat, T.; Wessler, B.S.
Magnetic circular dichroism and cobalt(II) binding equilibrium studies of Escherichia coli methionyl aminopeptidase
J. Am. Chem. Soc.
126
12316-12324
2004
Escherichia coli (P0AE18), Escherichia coli
Ye, Q.Z.; Xie, S.X.; Huang, M.; Huang, W.J.; Lu, J.P.; Ma, Z.Q.
Metalloform-selective inhibitors of escherichia coli methionine aminopeptidase and X-ray structure of a Mn(II)-form enzyme complexed with an inhibitor
J. Am. Chem. Soc.
126
13940-13941
2004
Escherichia coli
Zheng, Y.; Roberts, R.J.; Kasif, S.; Guan, C.
Characterization of two new aminopeptidases in Escherichia coli
J. Bacteriol.
187
3671-3677
2005
Escherichia coli
Li, J.Y.; Cui, Y.M.; Chen, L.L.; Gu, M.; Li, J.; Nan, F.J.; Ye, Q.Z.
Mutations at the S1 sites of methionine aminopeptidases from Escherichia coli and Homo sapiens reveal the residues critical for substrate specificity
J. Biol. Chem.
279
21128-21134
2004
Homo sapiens, Escherichia coli (P0AE18), Escherichia coli
Brdlik, C.M.; Crews, C.M.
A single amino acid residue defines the difference in ovalicin sensitivity between type I and II methionine aminopeptidases
J. Biol. Chem.
279
9475-9480
2004
Homo sapiens
Vetro, J.A.; Dummitt, B.; Micka, W.S.; Chang, Y.H.
Evidence of a dominant negative mutant of yeast methionine aminopeptidase type 2 in Saccharomyces cerevisiae
J. Cell. Biochem.
94
656-668
2005
Saccharomyces cerevisiae
Douangamath, A.; Dale, G.E.; D'Arcy, A.; Almstetter, M.; Eckl, R.; Frutos-Hoener, A.; Henkel, B.; Illgen, K.; Nerdinger, S.; Schulz, H.; MacSweeney, A.; Thormann, M.; Treml, A.; Pierau, S.; Wadman, S.; Oefner, C.
Crystal structures of Staphylococcus aureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate
J. Med. Chem.
47
1325-1328
2004
Staphylococcus aureus (P0A080), Staphylococcus aureus
Kallander, L.S.; Lu, Q.; Chen, W.; Tomaszek, T.; Yang, G.; Tew, D.; Meek, T.D.; Hofmann, G.A.; Schulz-Pritchard, C.K.; Smith, W.W.; Janson, C.A.; Ryan, M.D.; Zhang, G.F.; Johanson, K.O.; Kirkpatrick, R.B.; Ho, T.F.; Fisher, P.W.; Mattern, M.R.; Johnson, R.K.; Hansbury, M.J.; Winkler, J.D.; Ward, K.W.; Veber, D.F.; Thompson, S.K.
4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo
J. Med. Chem.
48
5644-5647
2005
Homo sapiens
Sheppard, G.S.; Wang, J.; Kawai, M.; Fidanze, S.D.; Bamaung, N.Y.; Erickson, S.A.; Barnes, D.M.; Tedrow, J.S.; Kolaczkowski, L.; Vasudevan, A.; Park, D.C.; Wang, G.T.; Sanders, W.J.; Mantei, R.A.; Palazzo, F.; Tucker-Garcia, L.; Lou, P.; Zhang, Q.; Park, C.H.; Kim, K.H.; Petros, A.; Olejniczak, E.; Nettesheim, D.; Hajduk, P.; Henkin, J.; Lesniewski, R.; Davidsen, S.K.; Bell, R.L.
Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding
J. Med. Chem.
49
3832-3849
2006
Homo sapiens (P50579), Homo sapiens
Schiffmann, R.; Neugebauer, A.; Klein, C.D.
Metal-mediated inhibition of Escherichia coli methionine aminopeptidase: structure-activity relationships and development of a novel scoring function for metal-ligand interactions
J. Med. Chem.
49
511-522
2006
Escherichia coli (P0AE18), Escherichia coli
Leszczyniecka, M.; Bhatia, U.; Cueto, M.; Nirmala, N.R.; Towbin, H.; Vattay, A.; Wang, B.; Zabludoff, S.; Phillips, P.E.
MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer
Oncogene
25
3471-3478
2006
Homo sapiens
Bernier, S.G.; Lazarus, D.D.; Clark, E.; Doyle, B.; Labenski, M.T.; Thompson, C.D.; Westlin, W.F.; Hannig, G.
A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis
Proc. Natl. Acad. Sci. USA
101
10768-10773
2004
Homo sapiens
Ye, Q.Z.; Xie, S.X.; Ma, Z.Q.; Huang, M.; Hanzlik, R.P.
Structural basis of catalysis by monometalated methionine aminopeptidase
Proc. Natl. Acad. Sci. USA
103
9470-9475
2006
Escherichia coli (P0AE18), Escherichia coli
Liao, Y.D.; Jeng, J.C.; Wang, C.F.; Wang, S.C.; Chang, S.T.
Removal of N-terminal methionine from recombinant proteins by engineered E. coli methionine aminopeptidase
Protein Sci.
13
1802-1810
2004
Escherichia coli
Spraggon, G.; Schwarzenbacher, R.; Kreusch, A.; McMullan, D.; Brinen, L.S.; Canaves, J.M.; Dai, X.; Deacon, A.M.; Elsliger, M.A.; Eshagi, S.; Floyd, R.; Godzik, A.; Grittini, C.; Grzechnik, S.K.; Jaroszewski, L.; Karlak, C.; Klock, H.E.; Koesema, E.; Kovarik, J.S.; Kuhn, P.; McPhillips, T.M.; Miller, M.D.; Morse, A.; Moy, K.; Ouyang, J.; Page, R.; Quijano, K.; Rezezadeh, F.; Robb, A.; Sims, E.; Stevens, R.C.; van den Bedem, H.; Velasquez, J.; Vincent, J.; von Delft, F.; Wang, X.; West, B.; Wolf, G.; Xu, Q.; Hodgson, K.O.; Wooley, J.; Lesley, S.A.; Wilson, I.A.
Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution
Proteins
56
396-400
2004
Thermotoga maritima
Hu, X.; Dang, Y.; Tenney, K.; Crews, P.; Tsai, C.W.; Sixt, K.M.; Cole, P.A.; Liu, J.O.
Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases
Chem. Biol.
14
764-774
2007
Homo sapiens (P50579), Homo sapiens (P53582)
Xie, S.X.; Huang, W.J.; Ma, Z.Q.; Huang, M.; Hanzlik, R.P.; Ye, Q.Z.
Structural analysis of metalloform-selective inhibition of methionine aminopeptidase
Acta Crystallogr. Sect. D
62
425-432
2006
Escherichia coli (P0AE18), Escherichia coli
Sawanyawisuth, K.; Wongkham, C.; Pairojkul, C.; Saeseow, O.T.; Riggins, G.J.; Araki, N.; Wongkham, S.
Methionine aminopeptidase 2 over-expressed in cholangiocarcinoma: potential for drug target
Acta Oncol.
46
378-385
2007
Homo sapiens (P50579), Homo sapiens
Kass, D.; Bridges, R.S.; Borczuk, A.; Greenberg, S.
Methionine aminopeptidase-2 as a selective target of myofibroblasts in pulmonary fibrosis
Am. J. Respir. Cell Mol. Biol.
37
193-201
2007
Mus musculus (O08663), Rattus norvegicus (P38062), Homo sapiens (P50579)
Mitra, S.; Dygas-Holz, A.M.; Jiracek, J.; Zertova, M.; Zakova, L.; Holz, R.C.
A new colorimetric assay for methionyl aminopeptidases: examination of the binding of a new class of pseudopeptide analog inhibitors
Anal. Biochem.
357
43-49
2006
Escherichia coli, Pyrococcus furiosus
Hu, X.; Addlagatta, A.; Matthews, B.W.; Liu, J.O.
Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases
Angew. Chem.
45
3772-3775
2006
Homo sapiens (P50579), Homo sapiens (P53582)
Upadhya, R.; Zhang, H.S.; Weiss, L.M.
System for expression of microsporidian methionine amino peptidase type 2 (MetAP2) in the yeast Saccharomyces cerevisiae
Antimicrob. Agents Chemother.
50
3389-3395
2006
Escherichia coli, Homo sapiens (P50579), Homo sapiens, Encephalitozoon cuniculi (Q8SR45), Encephalitozoon cuniculi
Bainbridge, J.; Madden, L.; Essex, D.; Binks, M.; Malhotra, R.; Paleolog, E.M.
Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition
Arthritis Res. Ther.
9
R127
2007
Mus musculus
Hannig, G.; Bernier, S.G.; Hoyt, J.G.; Doyle, B.; Clark, E.; Karp, R.M.; Lorusso, J.; Westlin, W.F.
Suppression of inflammation and structural damage in experimental arthritis through molecular targeted therapy with PPI-2458
Arthritis Rheum.
56
850-860
2007
Rattus norvegicus
Timmer, J.C.; Enoksson, M.; Wildfang, E.; Zhu, W.; Igarashi, Y.; Denault, J.B.; Ma, Y.; Dummitt, B.; Chang, Y.H.; Mast, A.E.; Eroshkin, A.; Smith, J.W.; Tao, W.A.; Salvesen, G.S.
Profiling constitutive proteolytic events in vivo
Biochem. J.
407
41-48
2007
Escherichia coli
Hu, X.V.; Chen, X.; Han, K.C.; Mildvan, A.S.; Liu, J.O.
Kinetic and mutational studies of the number of interacting divalent cations required by bacterial and human methionine aminopeptidases
Biochemistry
46
12833-12843
2007
Escherichia coli, Homo sapiens (Q6UB28), Homo sapiens
Nonato, M.C.; Widom, J.; Clardy, J.
Human methionine aminopeptidase type 2 in complex with L- and D-methionine
Bioorg. Med. Chem. Lett.
16
2580-2583
2006
Homo sapiens (P50579), Homo sapiens
Kawai, M.; BaMaung, N.Y.; Fidanze, S.D.; Erickson, S.A.; Tedrow, J.S.; Sanders, W.J.; Vasudevan, A.; Park, C.; Hutchins, C.; Comess, K.M.; Kalvin, D.; Wang, J.; Zhang, Q.; Lou, P.; Tucker-Garcia, L.; Bouska, J.; Bell, R.L.; Lesniewski, R.; Henkin, J.; Sheppard, G.S.
Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties
Bioorg. Med. Chem. Lett.
16
3574-3577
2006
Homo sapiens (P50579)
Wang, G.T.; Mantei, R.A.; Kawai, M.; Tedrow, J.S.; Barnes, D.M.; Wang, J.; Zhang, Q.; Lou, P.; Garcia, L.A.; Bouska, J.; Yates, M.; Park, C.; Judge, R.A.; Lesniewski, R.; Sheppard, G.S.; Bell, R.L.
Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids
Bioorg. Med. Chem. Lett.
17
2817-2822
2007
Mus musculus (O08663)
Haldar, M.K.; Scott, M.D.; Sule, N.; Srivastava, D.K.; Mallik, S.
Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors
Bioorg. Med. Chem. Lett.
18
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2008
Homo sapiens (P53582), Homo sapiens
Ma, Z.Q.; Xie, S.X.; Huang, Q.Q.; Nan, F.J.; Hurley, T.D.; Ye, Q.Z.
Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop adaptability in selective inhibition of bacterial enzymes
BMC Struct. Biol.
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Escherichia coli (P0AE18), Escherichia coli
Zhang, Y.; Yeh, J.R.; Mara, A.; Ju, R.; Hines, J.F.; Cirone, P.; Griesbach, H.L.; Schneider, I.; Slusarski, D.C.; Holley, S.A.; Crews, C.M.
A chemical and genetic approach to the mode of action of fumagillin
Chem. Biol.
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Danio rerio (Q7SXK1), Danio rerio
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Team work in protein processing
Chem. Biol.
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Homo sapiens (P50579), Homo sapiens (P53582)
Qiu, W.; Xu, J.; Li, J.; Li, J.; Nan, F.
Activity-based protein profiling for type I methionine aminopeptidase by using photo-affinity trimodular probes
Chembiochem
8
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2007
Escherichia coli
Kowalinski, E.; Bange, G.; Bradatsch, B.; Hurt, E.; Wild, K.; Sinning, I.
The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions
FEBS Lett.
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Homo sapiens (P50579), Homo sapiens
Lazarus, D.D.; Doyle, E.G.; Bernier, S.G.; Rogers, A.B.; Labenski, M.T.; Wakefield, J.D.; Karp, R.M.; Clark, E.J.; Lorusso, J.; Hoyt, J.G.; Thompson, C.D.; Hannig, G.; Westlin, W.F.
An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis
Inflamm. Res.
57
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Rattus norvegicus (P38062)
Hannig, G.; Lazarus, D.D.; Bernier, S.G.; Karp, R.M.; Lorusso, J.; Qiu, D.; Labenski, M.T.; Wakefield, J.D.; Thompson, C.D.; Westlin, W.F.
Inhibition of melanoma tumor growth by a pharmacological inhibitor of MetAP-2, PPI-2458
Int. J. Oncol.
28
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2006
Mus musculus
Leopoldini, M.; Russo, N.; Toscano, M.
Which one among Zn(II), Co(II), Mn(II), and Fe(II) is the most efficient ion for the methionine aminopeptidase catalyzed reaction?
J. Am. Chem. Soc.
129
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Escherichia coli
Fang, J.; Dong, Y.; Lushington, G.H.; Ye, Q.; Georg, G.I.
Support vector machines in HTS data mining: type I MetAPs inhibition study
J. Biomol. Screen.
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2006
Escherichia coli
Vedantham, P.; Guerra, J.M.; Schoenen, F.; Huang, M.; Gor, P.J.; Georg, G.I.; Wang, J.L.; Neuenswander, B.; Lushington, G.H.; Mitscher, L.A.; Ye, Q.Z.; Hanson, P.R.
Ionic immobilization, diversification, and release: application to the generation of a library of methionine aminopeptidase inhibitors
J. Comb. Chem.
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Escherichia coli
Vedantham, P.; Zhang, M.; Gor, P.J.; Huang, M.; Georg, G.I.; Lushington, G.H.; Mitscher, L.A.; Ye, Q.Z.; Hanson, P.R.
Studies towards the synthesis of methionine aminopeptidase inhibitors: diversification utilizing a ROMP-derived coupling reagent
J. Comb. Chem.
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Escherichia coli
Lu, J.; Chong, C.R.; Hu, X.; Liu, J.O.
Fumarranol, a rearranged fumagillin analogue that inhibits angiogenesis in vivo
J. Med. Chem.
49
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Homo sapiens (P50579)
Marino, J.P.; Fisher, P.W.; Hofmann, G.A.; Kirkpatrick, R.B.; Janson, C.A.; Johnson, R.K.; Ma, C.; Mattern, M.; Meek, T.D.; Ryan, M.D.; Schulz, C.; Smith, W.W.; Tew, D.G.; Tomazek, T.A.; Veber, D.F.; Xiong, W.C.; Yamamoto, Y.; Yamashita, K.; Yang, G.; Thompson, S.K.
Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore
J. Med. Chem.
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Homo sapiens (P50579), Homo sapiens
Huang, M.; Xie, S.X.; Ma, Z.Q.; Huang, Q.Q.; Nan, F.J.; Ye, Q.Z.
Inhibition of monometalated methionine aminopeptidase: inhibitor discovery and crystallographic analysis
J. Med. Chem.
50
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2007
Escherichia coli (P0AE18)
Noguchi, S.; Komiya, T.; Eguchi, H.; Shirahata, A.; Nikawa, J.; Kawamura, M.
Methionine aminopeptidase II: A molecular chaperone for sarcoplasmic reticulum calcium ATPase
J. Membr. Biol.
215
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Xenopus laevis (Q7ZY93)
Falb, M.; Aivaliotis, M.; Garcia-Rizo, C.; Bisle, B.; Tebbe, A.; Klein, C.; Konstantinidis, K.; Siedler, F.; Pfeiffer, F.; Oesterhelt, D.
Archaeal N-terminal protein maturation commonly involves N-terminal acetylation: a large-scale proteomics survey
J. Mol. Biol.
362
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2006
Halobacterium salinarum, Natronomonas pharaonis, Halobacterium salinarum RF1, Natronomonas pharaonis NRC-1
Frottin, F.; Martinez, A.; Peynot, P.; Mitra, S.; Holz, R.C.; Giglione, C.; Meinnel, T.
The proteomics of N-terminal methionine cleavage
Mol. Cell. Proteomics
5
2336-2349
2006
Escherichia coli
Bingel-Erlenmeyer, R.; Kohler, R.; Kramer, G.; Sandikci, A.; Antolic, S.; Maier, T.; Schaffitzel, C.; Wiedmann, B.; Bukau, B.; Ban, N.
A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing
Nature
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Mycobacterium tuberculosis
Zalucki, Y.M.; Power, P.M.; Jennings, M.P.
Selection for efficient translation initiation biases codon usage at second amino acid position in secretory proteins
Nucleic Acids Res.
35
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Escherichia coli
Tucker, L.A.; Zhang, Q.; Sheppard, G.S.; Lou, P.; Jiang, F.; McKeegan, E.; Lesniewski, R.; Davidsen, S.K.; Bell, R.L.; Wang, J.
Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation
Oncogene
2008
1-10
2008
Homo sapiens (P50579), Homo sapiens
Yeh, J.R.; Ju, R.; Brdlik, C.M.; Zhang, W.; Zhang, Y.; Matyskiela, M.E.; Shotwell, J.D.; Crews, C.M.
Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest
Proc. Natl. Acad. Sci. USA
103
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2006
Mus musculus (O08663), Mus musculus
Chen, X.; Chong, C.R.; Shi, L.; Yoshimoto, T.; Sullivan, D.J.; Liu, J.O.
Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity
Proc. Natl. Acad. Sci. USA
103
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2006
Plasmodium falciparum
Hu, X.; Addlagatta, A.; Lu, J.; Matthews, B.W.; Liu, J.O.
Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression
Proc. Natl. Acad. Sci. USA
103
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2006
Homo sapiens (P53582), Homo sapiens
Wang, J.; Tucker, L.A.; Stavropoulos, J.; Zhang, Q.; Wang, Y.C.; Bukofzer, G.; Niquette, A.; Meulbroek, J.A.; Barnes, D.M.; Shen, J.; Bouska, J.; Donawho, C.; Sheppard, G.S.; Bell, R.L.
Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor
Proc. Natl. Acad. Sci. USA
105
1838-1843
2008
Mus musculus (O08663), Mus musculus
Addlagatta, A.; Matthews, B.W.
Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human type 1 methionine aminopeptidase
Protein Sci.
15
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2006
Homo sapiens (P50579), Homo sapiens (P53582), Homo sapiens
Evdokimov, A.G.; Pokross, M.; Walter, R.L.; Mekel, M.; Barnett, B.L.; Amburgey, J.; Seibel, W.L.; Soper, S.J.; Djung, J.F.; Fairweather, N.; Diven, C.; Rastogi, V.; Grinius, L.; Klanke, C.; Siehnel, R.; Twinem, T.; Andrews, R.; Curnow, A.
Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors
Proteins
66
538-546
2007
Escherichia coli
Narayanan, S.S.; Ramanujan, A.; Krishna, S.; Nampoothiri, K.M.
Purification and biochemical characterization of methionine aminopeptidase (MetAP) from Mycobacterium smegmatis mc2155
Appl. Biochem. Biotechnol.
151
512-521
2008
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
Watterson, S.J.; Mitra, S.; Swierczek, S.I.; Bennett, B.; Holz, R.C.
Kinetic and spectroscopic analysis of the catalytic role of H79 in the methionine aminopeptidase from Escherichia coli
Biochemistry
47
11885-11893
2008
Escherichia coli
Mitra, S.; Bennett, B.; Holz, R.C.
Mutation of H63 and its catalytic affect on the methionine aminopeptidase from Escherichia coli
Biochim. Biophys. Acta
1794
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2009
Escherichia coli
Wang, W.L.; Chai, S.C.; Ye, Q.Z.
Synthesis and structure-function analysis of Fe(II)-form-selective antibacterial inhibitors of Escherichia coli methionine aminopeptidase
Bioorg. Med. Chem. Lett.
19
1080-1083
2009
Escherichia coli
Chen, X.; Xie, S.; Bhat, S.; Kumar, N.; Shapiro, T.A.; Liu, J.O.
Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo
Chem. Biol.
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2009
Plasmodium falciparum
Priest, R.C.; Spaull, J.; Buckton, J.; Grimley, R.L.; Sims, M.; Binks, M.; Malhotra, R.
Immunomodulatory activity of a methionine aminopeptidase-2 inhibitor on B cell differentiation
Clin. Exp. Immunol.
155
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2009
Callithrix jacchus, Homo sapiens, Mus musculus
Mitra, S.; Job, K.M.; Meng, L.; Bennett, B.; Holz, R.C.
Analyzing the catalytic role of Asp97 in the methionine aminopeptidase from Escherichia coli
FEBS J.
275
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2008
Escherichia coli (P0AE18), Escherichia coli
Larrabee, J.A.; Chyun, S.A.; Volwiler, A.S.
Magnetic circular dichroism study of a dicobalt(II) methionine aminopeptidase/fumagillin complex and dicobalt II-II and II-III model complexes
Inorg. Chem.
47
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2008
Escherichia coli
Chai, S.C.; Wang, W.L.; Ye, Q.Z.
FE(II) is the native cofactor for Escherichia coli methionine aminopeptidase
J. Biol. Chem.
283
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2008
Escherichia coli
Mitra, S.; Sheppard, G.; Wang, J.; Bennett, B.; Holz, R.C.
Analyzing the binding of Co(II)-specific inhibitors to the methionyl aminopeptidases from Escherichia coli and Pyrococcus furiosus
J. Biol. Inorg. Chem.
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2009
Escherichia coli, Pyrococcus furiosus
Wang, W.L.; Chai, S.C.; Huang, M.; He, H.Z.; Hurley, T.D.; Ye, Q.Z.
Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity
J. Med. Chem.
51
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2008
Escherichia coli (P0AE18), Escherichia coli
Warder, S.E.; Tucker, L.A.; McLoughlin, S.M.; Strelitzer, T.J.; Meuth, J.L.; Zhang, Q.; Sheppard, G.S.; Richardson, P.L.; Lesniewski, R.; Davidsen, S.K.; Bell, R.L.; Rogers, J.C.; Wang, J.
Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition
J. Proteome Res.
7
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2008
Homo sapiens, Mus musculus
Drath, M.; Baier, K.; Forchhammer, K.
An alternative methionine aminopeptidase, MAP-2, is required for nitrogen starvation and high-light acclimation in the cyanobacterium Synechocystis sp. PCC 6803
Microbiology
155
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2009
Synechocystis sp. PCC 6803
Chai, S.C.; Lu, J.P.; Ye, Q.Z.
Determination of binding affinity of metal cofactor to the active site of methionine aminopeptidase based on quantitation of functional enzyme
Anal. Biochem.
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Mycobacterium tuberculosis
Atanassova, A.; Sugita, M.; Sugiura, M.; Pajpanova, T.; Ivanov, I.
Molecular cloning, expression and characterization of three distinctive genes encoding methionine aminopeptidases in cyanobacterium Synechocystis sp. strain PCC6803
Arch. Microbiol.
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Synechocystis sp.
Chai, S.C.; Ye, Q.Z.
Metal-mediated inhibition is a viable approach for inhibiting cellular methionine aminopeptidase
Bioorg. Med. Chem. Lett.
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6862-6864
2009
Escherichia coli
Chai, S.C.; Ye, Q.Z.
A cell-based assay that targets methionine aminopeptidase in a physiologically relevant environment
Bioorg. Med. Chem. Lett.
20
2129-2132
2010
Escherichia coli
Lu, J.P.; Ye, Q.Z.
Expression and characterization of Mycobacterium tuberculosis methionine aminopeptidase type 1a
Bioorg. Med. Chem. Lett.
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2776-2779
2010
Mycobacterium tuberculosis
Chai, S.; Ye, Q.
Analysis of the stoichiometric metal activation of methionine aminopeptidase
BMC Biochem.
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32
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Escherichia coli
Zhang, X.; Chen, S.; Hu, Z.; Zhang, L.; Wang, H.
Expression and characterization of two functional methionine aminopeptidases from Mycobacterium tuberculosis H37Rv
Curr. Microbiol.
59
520-525
2009
Mycobacterium tuberculosis
Trenholme, K.R.; Brown, C.L.; Skinner-Adams, T.S.; Stack, C.; Lowther, J.; To, J.; Robinson, M.W.; Donnelly, S.M.; Dalton, J.P.; Gardiner, D.L.
Aminopeptidases of malaria parasites: new targets for chemotherapy
Infect. Disord. Drug Targets
10
217-225
2010
Plasmodium falciparum
Arico-Muendel, C.C.; Benjamin, D.R.; Caiazzo, T.M.; Centrella, P.A.; Contonio, B.D.; Cook, C.M.; Doyle, E.G.; Hannig, G.; Labenski, M.T.; Searle, L.L.; Lind, K.; Morgan, B.A.; Olson, G.; Paradise, C.L.; Self, C.; Skinner, S.R.; Sluboski, B.; Svendsen, J.L.; Thompson, C.D.; Westlin, W.; White, K.F.
Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2
J. Med. Chem.
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2009
Homo sapiens
Lu, J.P.; Chai, S.C.; Ye, Q.Z.
Catalysis and inhibition of Mycobacterium tuberculosis methionine aminopeptidase
J. Med. Chem.
53
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Mycobacterium tuberculosis (P9WK19), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WK19)
Alvarado, J.J.; Nemkal, A.; Sauder, J.M.; Russell, M.; Akiyoshi, D.E.; Shi, W.; Almo, S.C.; Weiss, L.M.
Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470
Mol. Biochem. Parasitol.
168
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2009
Encephalitozoon cuniculi, Enterocytozoon bieneusi (B7XJ30), Enterocytozoon bieneusi, Enterocytozoon bieneusi H348 (B7XJ30), Homo sapiens
Selvakumar, P.; Lakshmikuttyamma, A.; Das, U.; Pati, H.N.; Dimmock, J.R.; Sharma, R.K.
NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells
Mol. Cancer
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65
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Homo sapiens
Xiao, Q.; Zhang, F.; Nacev, B.A.; Liu, J.O.; Pei, D.
Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases
Biochemistry
49
5588-5599
2010
Escherichia coli, Homo sapiens
Altmeyer, M.A.; Marschner, A.; Schiffmann, R.; Klein, C.D.
Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors
Bioorg. Med. Chem. Lett.
20
4038-4044
2010
Escherichia coli, Homo sapiens, Staphylococcus aureus
Yuan, H.; Chai, S.C.; Lam, C.K.; Howard Xu, H.; Ye, Q.Z.
Two methionine aminopeptidases from Acinetobacter baumannii are functional enzymes
Bioorg. Med. Chem. Lett.
21
3395-3398
2011
Acinetobacter baumannii (A0A1E3MBK2), Acinetobacter baumannii, Acinetobacter baumannii ATCC 17978 (A0A1E3MBK2)
Hou, Y.P.; Sun, J.; Pang, Z.H.; Lv, P.C.; Li, D.D.; Yan, L.; Zhang, H.J.; Zheng, E.X.; Zhao, J.; Zhu, H.L.
Synthesis and antitumor activity of 1,2,4-triazoles having 1,4-benzodioxan fragment as a novel class of potent methionine aminopeptidase type II inhibitors
Bioorg. Med. Chem.
19
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2011
Homo sapiens
Ma, A.C.; Fung, T.K.; Lin, R.H.; Chung, M.I.; Yang, D.; Ekker, S.C.; Leung, A.Y.
Methionine aminopeptidase 2 is required for hematopoietic stem cell initiation and proliferation
Blood
118
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2011
Danio rerio, Homo sapiens
Kanudia, P.; Mittal, M.; Kumaran, S.; Chakraborti, P.
Amino-terminal extension present in the methionine aminopeptidase type 1c of Mycobacterium tuberculosis is indispensible for its activity
BMC Biochem.
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2011
Mycobacterium tuberculosis
Lu, J.P.; Yuan, X.H.; Yuan, H.; Wang, W.L.; Wan, B.; Franzblau, S.G.; Ye, Q.Z.
Inhibition of Mycobacterium tuberculosis methionine aminopeptidases by bengamide derivatives
ChemMedChem
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1041-1048
2011
Mycobacterium tuberculosis
Shapiro, A.B.; Gao, N.; Thresher, J.; Walkup, G.K.; Whiteaker, J.
A high-throughput absorbance-based assay for methionine produced by methionine aminopeptidase using S-adenosyl-L-methionine synthetase
J. Biomol. Screen.
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494-505
2011
Escherichia coli, Escherichia coli K-12 MG1655
Jeong, H.J.; Shin, J.S.; Ok, S.H.
Barley DNA-binding methionine aminopeptidase, which changes the localization from the nucleus to the cytoplasm by low temperature, is involved in freezing tolerance
Plant Sci.
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2011
Hordeum vulgare (E0A9F0), Hordeum vulgare
Tahirov, T.H.; Oki, H.; Tsukihara, T.; Ogasahara, K.; Yutani, K.; Libeu, C.P.; Izu, Y.; Tsunasawa, S.; Kato, I.
High-resolution crystals of methionine aminopeptidase from Pyrococcus furiosus obtained by water-mediated transformation
J. Struct. Biol.
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Pyrococcus furiosus (P56218), Pyrococcus furiosus
Reddi, R.; Arya, T.; Kishor, C.; Gumpena, R.; Ganji, R.J.; Bhukya, S.; Addlagatta, A.
Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
FEBS J.
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Mycobacterium tuberculosis (P9WK19), Mycobacterium tuberculosis ATCC 25618 (P9WK19)
Chiu, J.; Wong, J.W.; Hogg, P.J.
Redox regulation of methionine aminopeptidase 2 activity
J. Biol. Chem.
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Homo sapiens (P50579)
Zhang, F.; Bhat, S.; Gabelli, S.B.; Chen, X.; Miller, M.S.; Nacev, B.A.; Cheng, Y.L.; Meyers, D.J.; Tenney, K.; Shim, J.S.; Crews, P.; Amzel, L.M.; Ma, D.; Liu, J.O.
Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells
J. Med. Chem.
56
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2013
Homo sapiens (P53582), Homo sapiens
Kishor, C.; Gumpena, R.; Reddi, R.; Addlagatta, A.
Structural studies of Enterococcus faecalis methionine aminopeptidase and design of microbe specific 2,2'-bipyridine based inhibitors
MedChemComm
3
1406-1412
2012
Enterococcus faecalis
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Narayanan, S.S.; Nampoothiri, K.M.
Biochemical characterization of recombinant methionine aminopeptidases (MAPs) from Mycobacterium tuberculosis H37Rv
Mol. Cell. Biochem.
365
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2012
Mycobacterium tuberculosis (P9WK19), Mycobacterium tuberculosis (P9WK21), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WK19), Mycobacterium tuberculosis H37Rv (P9WK21), Mycobacterium tuberculosis H37Rv
Arya, T.; Kishor, C.; Saddanapu, V.; Reddi, R.; Addlagatta, A.
Discovery of a new genetic variant of methionine aminopeptidase from Streptococci with possible post-translational modifications: biochemical and structural characterization
PLoS ONE
8
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2013
Streptococcus pneumoniae (B2IQ22), Streptococcus pneumoniae, Streptococcus pneumoniae CGSP14 (B2IQ22)
Kang, J.; Ju, J.; Kim, J.; Ju, H.; Lee, J.; Lee, K.; Lee, W.; Sohn, W.; Kim, T.; Na, B.
Expression and biochemical characterization of a type I methionine aminopeptidase of Plasmodium vivax
Protein Expr. Purif.
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2015
Plasmodium vivax (A5K7H9), Plasmodium vivax, Plasmodium vivax Salvador I (A5K7H9)
Calcagno, S.; Klein, C.D.
N-Terminal methionine processing by the zinc-activated Plasmodium falciparum methionine aminopeptidase 1b
Appl. Microbiol. Biotechnol.
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Plasmodium falciparum (KT943909), Plasmodium falciparum
Arif, A.; Gardner, Q.; Rashid, N.; Akhtar, M.
Production of human interferon alpha-2b in Escherichia coli and removal of N-terminal methionine utilizing archaeal methionine aminopeptidase
Biologia (Poland)
70
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2015
Pyrococcus furiosus
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Helgren, T.R.; Chen, C.; Wangtrakuldee, P.; Edwards, T.E.; Staker, B.L.; Abendroth, J.; Sankaran, B.; Housley, N.A.; Myler, P.J.; Audia, J.P.; Horn, J.R.; Hagen, T.J.
Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents
Bioorg. Med. Chem.
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2017
Rickettsia prowazekii (Q9ZCD3), Rickettsia prowazekii, Rickettsia prowazekii Madrid E (Q9ZCD3)
Rose, J.A.; Lahiri, S.D.; McKinney, D.C.; Albert, R.; Morningstar, M.L.; Shapiro, A.B.; Fisher, S.L.; Fleming, P.R.
Novel broad-spectrum inhibitors of bacterial methionine aminopeptidase
Bioorg. Med. Chem. Lett.
25
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2015
Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Escherichia coli (P0AE18)
Heinrich, T.; Buchstaller, H.P.; Cezanne, B.; Rohdich, F.; Bomke, J.; Friese-Hamim, M.; Krier, M.; Knoechel, T.; Musil, D.; Leuthner, B.; Zenke, F.
Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates
Bioorg. Med. Chem. Lett.
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2017
Homo sapiens (P50579)
Vanunu, M.; Schall, P.; Reingewertz, T.H.; Chakraborti, P.K.; Grimm, B.; Barkan, D.
MapB protein is the essential methionine aminopeptidase in Mycobacterium tuberculosis
Cells
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Mycobacterium tuberculosis variant bovis (A0A0H3M2X0), Mycobacterium tuberculosis variant bovis (A0A0H3M9T2)
Bhat, S.Y.; Dey, A.; Qureshi, I.A.
Structural and functional highlights of methionine aminopeptidase 2 from Leishmania donovani
Int. J. Biol. Macromol.
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2018
Leishmania donovani (A0A3S7WWI2), Leishmania donovani
Arya, T.; Reddi, R.; Kishor, C.; Ganji, R.J.; Bhukya, S.; Gumpena, R.; McGowan, S.; Drag, M.; Addlagatta, A.
Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases
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Streptococcus pneumoniae (B2IQ22), Homo sapiens (P53582), Homo sapiens, Streptococcus pneumoniae CGSP14 (B2IQ22)
Reddi, R.; Singarapu, K.K.; Pal, D.; Addlagatta, A.
The unique functional role of the C-HS hydrogen bond in the substrate specificity and enzyme catalysis of type 1 methionine aminopeptidase
Mol. Biosyst.
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2016
Mycobacterium tuberculosis (P9WK19), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WK19)
Van Damme, P.; Hole, K.; Gevaert, K.; Arnesen, T.
N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases
Proteomics
15
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2015
Homo sapiens (P50579), Homo sapiens
Kumar, R.; Tiwari, K.; Dubey, V.K.
Methionine aminopeptidase 2 is a key regulator of apoptotic like cell death in Leishmania donovani
Sci. Rep.
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95
2017
Leishmania donovani (E9BF82), Leishmania donovani, Leishmania donovani BPK282A1 (E9BF82)
John, S.; Aniemeke, E.; Ha, N.; Chong, C.; Gu, P.; Zhou, J.; Zhang, Y.; Graviss, E.; Liu, J.; Olaleye, O.
Characterization of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone as a novel inhibitor of methionine aminopeptidases from Mycobacterium tuberculosis
Tuberculosis
101
S73-S77
2016
Mycobacterium tuberculosis
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