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Information on EC 3.4.11.18 - methionyl aminopeptidase and Organism(s) Mus musculus and UniProt Accession O08663

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.18 methionyl aminopeptidase
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This record set is specific for:
Mus musculus
UNIPROT: O08663 not found.
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The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
map-2, metap2, metap, methionine aminopeptidase, metap-2, metap1, methionine aminopeptidase 2, methionine aminopeptidase-2, metap-1, methionyl aminopeptidase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methionine aminopeptidase 2
-
methionine aminopeptidase-2
-
methionine aminopetidase-2
-
aminopeptidase, methionine
-
-
-
-
initiation factor 2 associated 67 kDa glycoprotein
-
-
-
-
L-methionine aminopeptidase
-
-
-
-
MAP
-
-
-
-
MetAP
-
-
-
-
MetAP-1
-
-
-
-
MetAP-2
MetAP1
-
-
-
-
MetAP2
methionine aminopeptidase
-
-
-
-
methionine aminopeptidase-2
-
-
p67
-
-
-
-
p67eIF2
-
-
-
-
peptidase M
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
CAS REGISTRY NUMBER
COMMENTARY hide
61229-81-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GAPDH + H2O
?
show the reaction diagram
MetAP2-specific substrate
-
-
?
Met-peptide + H2O
Met + peptide
show the reaction diagram
-
-
-
?
cyclophillin A + H2O
?
show the reaction diagram
-
MetAP2-specific substrate
-
-
?
eukaryotic elongation factor-2 + H2O
?
show the reaction diagram
-
MetAP2-specific substrate
-
-
?
glyceraldehye 3-phosphate dehydrogenase + H2O
?
show the reaction diagram
-
MetAP2-specific substrate
-
-
?
L-Met-Gly-L-Trp-L-Met-L-Asp + H2O
L-Met + Gly-L-Trp-L-Met-L-Asp
show the reaction diagram
-
-
-
-
?
L-Met-L-Pro-p-nitroanilide + H2O
L-Met + L-Pro-p-nitroanilide
show the reaction diagram
-
-
-
-
?
SH3 binding glutamic acid rich-like protein + H2O
?
show the reaction diagram
-
MetAP2-specific substrate
-
-
?
thioredoxin-1 + H2O
?
show the reaction diagram
-
MetAP2-specific substrate
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Met-peptide + H2O
Met + peptide
show the reaction diagram
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-(2-aminoethoxy)-3-ethyl-6-[[(2-propylphenyl)sulfonyl]amino]benzoic acid
-
2-(2-aminoethoxy)-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
-
2-(2-aminoethoxy)-6-[([2-[3-(diethylamino)propyl]-4-fluorophenyl]sulfonyl)amino]-3-ethylbenzoic acid
-
2-(carboxymethoxy)-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
-
2-butyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid
-
2-chloro-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
-
2-ethenyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid
-
2-ethoxy-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
-
2-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methoxybenzoic acid
-
2-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid
-
2-[(phenylsulfonyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
potent inhibitor but lacks cellular activity and is highly protein bound
3-ethyl-2-methoxy-6-[[(2-[[2-(1-methylpyrrolidin-2-yl)ethyl]amino]phenyl)sulfonyl]amino]benzoic acid
-
3-ethyl-2-methoxy-6-[[(2-[[3-(2-methylpiperidin-1-yl)propyl]amino]phenyl)sulfonyl]amino]benzoic acid
-
3-ethyl-2-methyl-6-[(pyridin-2-ylsulfonyl)amino]benzoic acid
-
5-ethyl-2-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
-
6-[([2-[(1E)-3-(diethylamino)prop-1-en-1-yl]-4-fluorophenyl]sulfonyl)amino]-3-ethyl-2-methoxybenzoic acid
-
6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-(1H-imidazol-4-yl)-3-methoxybenzoic acid
-
6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-furan-2-yl-3-methoxybenzoic acid
-
6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-furan-3-yl-3-methoxybenzoic acid
-
6-[[(2-[(1E)-3-(diethylamino)prop-1-en-1-yl]-4-fluorophenyl]sulfonyl)amino]-3-furan-3-yl-2-methoxybenzoic acid
-
6-[[(2-[[3-(dimethylamino)propyl]amino]-4-fluorophenyl)sulfonyl]amino]-3-furan-3-yl-2-methoxybenzoic acid
-
6-[[(2-[[4-(dimethylamino)butyl]amino]phenyl)sulfonyl]amino]-3-ethyl-2-methoxybenzoic acid
-
6-[[(4-fluorophenyl)sulfonyl]amino]-2,3-dimethylbenzoic acid
-
6-[[(4-fluorophenyl)sulfonyl]amino]-2-(1-hydroxyethyl)-3-methylbenzoic acid
-
6-[[(4-fluorophenyl)sulfonyl]amino]-2-(hydroxymethyl)-3-methylbenzoic acid
-
6-[[(4-fluorophenyl)sulfonyl]amino]-2-furan-3-yl-3-methoxybenzoic acid
-
6-[[(4-fluorophenyl)sulfonyl]amino]-2-methoxy-3-(1H-pyrazol-4-yl)benzoic acid
-
6-[[(4-fluorophenyl)sulfonyl]amino]-3-methyl-2-propylbenzoic acid
-
fumagillin
TNP-470
A-357300
-
potent MetAP2 inhibitor
A-800141
-
potent MetAP2 inhibitor
fumagillin
PPI-2458
TNP-470
-
potent MetAP2 inhibitor
[(1R)-1-carbamoyl-2-methyl-propyl]-carbamic acid-(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiranyl]-1-oxaspiro(2,5)oct-6-yl ester
-
PPI-2458, potent inhibitor
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000016
2-(2-aminoethoxy)-3-ethyl-6-[[(2-propylphenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.000046
2-(2-aminoethoxy)-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.000024
2-(2-aminoethoxy)-6-[([2-[3-(diethylamino)propyl]-4-fluorophenyl]sulfonyl)amino]-3-ethylbenzoic acid
Mus musculus
-
0.0058
2-(carboxymethoxy)-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.0013
2-butyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid
Mus musculus
-
0.000015
2-chloro-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.00006
2-ethenyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid
Mus musculus
-
0.000038
2-ethoxy-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.000011
2-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methoxybenzoic acid
Mus musculus
-
0.000016
2-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid
Mus musculus
-
0.000009
2-[(phenylsulfonyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
Mus musculus
-
0.000015
3-ethyl-2-methoxy-6-[[(2-[[2-(1-methylpyrrolidin-2-yl)ethyl]amino]phenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.000018
3-ethyl-2-methoxy-6-[[(2-[[3-(2-methylpiperidin-1-yl)propyl]amino]phenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.000067
3-ethyl-2-methyl-6-[(pyridin-2-ylsulfonyl)amino]benzoic acid
Mus musculus
-
0.000055
5-ethyl-2-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.000026
6-[([2-[(1E)-3-(diethylamino)prop-1-en-1-yl]-4-fluorophenyl]sulfonyl)amino]-3-ethyl-2-methoxybenzoic acid
Mus musculus
-
0.036
6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-(1H-imidazol-4-yl)-3-methoxybenzoic acid
Mus musculus
-
0.001
6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-furan-2-yl-3-methoxybenzoic acid
Mus musculus
-
0.00002
6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-furan-3-yl-3-methoxybenzoic acid
Mus musculus
-
0.000015
6-[[(2-[(1E)-3-(diethylamino)prop-1-en-1-yl]-4-fluorophenyl]sulfonyl)amino]-3-furan-3-yl-2-methoxybenzoic acid
Mus musculus
-
0.000017
6-[[(2-[[3-(dimethylamino)propyl]amino]-4-fluorophenyl)sulfonyl]amino]-3-furan-3-yl-2-methoxybenzoic acid
Mus musculus
-
0.00001
6-[[(2-[[4-(dimethylamino)butyl]amino]phenyl)sulfonyl]amino]-3-ethyl-2-methoxybenzoic acid
Mus musculus
-
0.000078
6-[[(4-fluorophenyl)sulfonyl]amino]-2,3-dimethylbenzoic acid
Mus musculus
-
0.0025
6-[[(4-fluorophenyl)sulfonyl]amino]-2-(1-hydroxyethyl)-3-methylbenzoic acid
Mus musculus
-
0.008
6-[[(4-fluorophenyl)sulfonyl]amino]-2-(hydroxymethyl)-3-methylbenzoic acid
Mus musculus
-
0.000008
6-[[(4-fluorophenyl)sulfonyl]amino]-2-furan-3-yl-3-methoxybenzoic acid
Mus musculus
-
0.00028
6-[[(4-fluorophenyl)sulfonyl]amino]-2-methoxy-3-(1H-pyrazol-4-yl)benzoic acid
Mus musculus
-
0.00015
6-[[(4-fluorophenyl)sulfonyl]amino]-3-methyl-2-propylbenzoic acid
Mus musculus
-
0.00012
A-357300
Mus musculus
MetAP2
0.000008
A-800141
Mus musculus
MetAP2
0.000012
TNP-470
Mus musculus
MetAP2
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
-
MetAP-2 is not detected in spleen
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MAP2_MOUSE
478
0
52922
Swiss-Prot
other Location (Reliability: 1)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Mono Q column chromatography and Q-Sepharose column chromatography
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kass, D.; Bridges, R.S.; Borczuk, A.; Greenberg, S.
Methionine aminopeptidase-2 as a selective target of myofibroblasts in pulmonary fibrosis
Am. J. Respir. Cell Mol. Biol.
37
193-201
2007
Mus musculus (O08663), Rattus norvegicus (P38062), Homo sapiens (P50579)
Manually annotated by BRENDA team
Bainbridge, J.; Madden, L.; Essex, D.; Binks, M.; Malhotra, R.; Paleolog, E.M.
Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition
Arthritis Res. Ther.
9
R127
2007
Mus musculus
Manually annotated by BRENDA team
Wang, G.T.; Mantei, R.A.; Kawai, M.; Tedrow, J.S.; Barnes, D.M.; Wang, J.; Zhang, Q.; Lou, P.; Garcia, L.A.; Bouska, J.; Yates, M.; Park, C.; Judge, R.A.; Lesniewski, R.; Sheppard, G.S.; Bell, R.L.
Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids
Bioorg. Med. Chem. Lett.
17
2817-2822
2007
Mus musculus (O08663)
Manually annotated by BRENDA team
Hannig, G.; Lazarus, D.D.; Bernier, S.G.; Karp, R.M.; Lorusso, J.; Qiu, D.; Labenski, M.T.; Wakefield, J.D.; Thompson, C.D.; Westlin, W.F.
Inhibition of melanoma tumor growth by a pharmacological inhibitor of MetAP-2, PPI-2458
Int. J. Oncol.
28
955-963
2006
Mus musculus
Manually annotated by BRENDA team
Yeh, J.R.; Ju, R.; Brdlik, C.M.; Zhang, W.; Zhang, Y.; Matyskiela, M.E.; Shotwell, J.D.; Crews, C.M.
Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest
Proc. Natl. Acad. Sci. USA
103
10379-10384
2006
Mus musculus (O08663), Mus musculus
Manually annotated by BRENDA team
Wang, J.; Tucker, L.A.; Stavropoulos, J.; Zhang, Q.; Wang, Y.C.; Bukofzer, G.; Niquette, A.; Meulbroek, J.A.; Barnes, D.M.; Shen, J.; Bouska, J.; Donawho, C.; Sheppard, G.S.; Bell, R.L.
Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor
Proc. Natl. Acad. Sci. USA
105
1838-1843
2008
Mus musculus (O08663), Mus musculus
Manually annotated by BRENDA team
Priest, R.C.; Spaull, J.; Buckton, J.; Grimley, R.L.; Sims, M.; Binks, M.; Malhotra, R.
Immunomodulatory activity of a methionine aminopeptidase-2 inhibitor on B cell differentiation
Clin. Exp. Immunol.
155
514-522
2009
Callithrix jacchus, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Warder, S.E.; Tucker, L.A.; McLoughlin, S.M.; Strelitzer, T.J.; Meuth, J.L.; Zhang, Q.; Sheppard, G.S.; Richardson, P.L.; Lesniewski, R.; Davidsen, S.K.; Bell, R.L.; Rogers, J.C.; Wang, J.
Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition
J. Proteome Res.
7
4807-4820
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team