Information on EC 3.3.2.4 - trans-epoxysuccinate hydrolase

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The expected taxonomic range for this enzyme is: Proteobacteria

EC NUMBER
COMMENTARY
3.3.2.4
-
RECOMMENDED NAME
GeneOntology No.
trans-epoxysuccinate hydrolase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
trans-2,3-epoxysuccinate + H2O = meso-tartrate
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of ether bond
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Glyoxylate and dicarboxylate metabolism
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SYSTEMATIC NAME
IUBMB Comments
trans-2,3-epoxysuccinate hydrolase
Acts on both optical isomers of the substrate.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
EC 4.2.1.37
-
-
formerly
-
hydratase, trans-epoxysuccinate
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-
-
-
tartrate epoxydase
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-
-
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trans-epoxysuccinate hydratase
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-
-
-
CAS REGISTRY NUMBER
COMMENTARY
37290-73-6
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Achromobacter viscosum
strain BAC-24, immoblized cells
-
-
Manually annotated by BRENDA team
Achromobacter viscosum BAC-24
strain BAC-24, immoblized cells
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
monobutyrylcholine epoxysuccinate + H2O
L-(+)-butyrylcholine bitartrate
show the reaction diagram
Achromobacter viscosum, Achromobacter viscosum BAC-24
-
-
-
?
trans-2,3-epoxysuccinate + H2O
meso-tartrate
show the reaction diagram
-
D- and L-trans-2,3-epoxysuccinate, not: cis-epoxysuccinate, carbon source
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
trans-2,3-epoxysuccinate + H2O
meso-tartrate
show the reaction diagram
-
carbon source
-
?
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
p-chloromercuribenzoate
-
-
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.885
-
D,L-trans-2,3-epoxysuccinate
-
-
2.15
-
L-trans-2,3-epoxysuccinate
-
-
TURNOVER NUMBER [1/s]
TURNOVER NUMBER MAXIMUM[1/s]
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
83.3
-
D-trans-2,3-epoxysuccinate
-
-
317
-
L-trans-2,3-epoxysuccinate
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
7
10
-
pH 7: 10% of optimal activity, pH 10: 20% of optimal activity
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
66300
-
-
sedimentation velocity, diffusion coefficient
Crystallization/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
APPLICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pharmacology
Achromobacter viscosum
-
the reaction product L-(+)-butyrylcholine bitartrate may be used as a lecithin substitute
pharmacology
Achromobacter viscosum BAC-24
-
the reaction product L-(+)-butyrylcholine bitartrate may be used as a lecithin substitute
-