Information on EC 3.3.2.15 - trans-2,3-dihydro-3-hydroxyanthranilic acid synthase

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The expected taxonomic range for this enzyme is: Pseudomonas

EC NUMBER
COMMENTARY hide
3.3.2.15
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RECOMMENDED NAME
GeneOntology No.
trans-2,3-dihydro-3-hydroxyanthranilic acid synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate + pyruvate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
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Phenazine biosynthesis
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phenazine-1-carboxylate biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
(2S)-2-amino-4-deoxychorismate pyruvate-hydrolase
Isolated from the bacterium Pseudomonas aeruginosa. Involved in phenazine biosynthesis.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
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the enzyme is involved in phenazine biosynthesis
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2S)-2-amino-4-deoxychorismate + H2O
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate + pyruvate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(2S)-2-amino-4-deoxychorismate + H2O
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate + pyruvate
show the reaction diagram
Q7DC80
the enzyme is involved in phenazine biosynthesis
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate i.e. trans-2,3-dihydro-3-hydroxyanthranilate
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?
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
phzD is expressed as part of the phenazine biosynthetic operon
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
loss of PhzD in the phenazine biosynthetic operon expressed in Escherichia coli does not result in the loss of phenazine production. Escherichia coli pyridoxamine oxidases may complement phzD function