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Disease on EC 3.3.1.1 - adenosylhomocysteinase

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DISEASE
TITLE OF PUBLICATION
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Acidosis, Lactic
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
adenosine deaminase deficiency
Decreased S-adenosylhomocysteine hydrolase in inborn errors of purine metabolism.
In vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine in adenosine deaminase-deficient patients.
The human genes for S-adenosylhomocysteine hydrolase and adenosine deaminase are syntenic on chromosome 20.
adenosine kinase deficiency
Consensus recommendations for the diagnosis, treatment and follow-up of inherited methylation disorders.
S-adenosylhomocysteine hydrolase inactivation and purine toxicity in cultured human T- and B-lymphoblasts.
S-adenosylmethionine induces mitochondrial dysfunction, permeability transition pore opening and redox imbalance in subcellular preparations of rat liver.
adenosylhomocysteinase deficiency
A single mutation at Tyr143 of human S-adenosylhomocysteine hydrolase renders the enzyme thermosensitive and affects the oxidation state of bound cofactor nicotinamide-adenine dinucleotide.
A Turkish patient with novel AHCY variants and presumed diagnosis of S-adenosylhomocysteine hydrolase deficiency.
Adult-onset liver disease and hepatocellular carcinoma in S-adenosylhomocysteine hydrolase deficiency.
Clinical picture of S-adenosylhomocysteine hydrolase deficiency resembles phosphomannomutase 2 deficiency.
CRB1-related retinopathy overlapping the ocular phenotype of S-adenosylhomocysteine hydrolase deficiency.
Disruption of Brain Redox Homeostasis, Microglia Activation and Neuronal Damage Induced by Intracerebroventricular Administration of S-Adenosylmethionine to Developing Rats.
Familial hypermethioninemia partially responsive to dietary restriction.
Homocysteine as a risk factor for atherosclerosis: is its conversion to s-adenosyl-L-homocysteine the key to deregulated lipid metabolism?
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Inherited disorders in the conversion of methionine to homocysteine.
Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency.
Plasma biomarker identification in S-adenosylhomocysteine hydrolase deficiency.
Proposed explanation for S-adenosylhomocysteine hydrolase deficiency in purine nucleoside phosphorylase and hypoxanthine-guanine phosphoribosyltransferase-deficient patients.
S-Adenosylhomocysteine hydrolase (AdoHcyase) deficiency: enzymatic capabilities of human AdoHcyase are highly effected by changes to codon 89 and its surrounding residues.
S-adenosylhomocysteine hydrolase deficiency in a 26-year-old man.
S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism.
S-Adenosylhomocysteine hydrolase deficiency in cysteine auxotrophs of Tetrahymena thermophila.
S-Adenosylhomocysteine hydrolase deficiency: A second patient, the younger brother of the index patient, and outcomes during therapy.
S-adenosylhomocysteine hydrolase deficiency: two siblings with fetal hydrops and fatal outcomes.
S-Adenosylmethionine Promotes Oxidative Stress and Decreases Na
Transcriptome profiling and methyl homeostasis of an Arabidopsis mutant deficient in S-adenosylhomocysteine hydrolase1 (SAHH1).
African Swine Fever
Activity of several S-adenosylhomocysteine hydrolase inhibitors against African swine fever virus replication in Vero cells.
Albuminuria
Gene expression profile in diabetic KK/Ta mice.
Anemia
S-adenosylhomocysteine hydrolase, S-adenosylmethionine, S-adenosylhomocysteine: correlations with ribavirin induced anemia.
Anemia, Hypochromic
Effects of the crinivirus coat protein-interacting plant protein SAHH on post-transcriptional RNA silencing and its suppression.
Arthritis
Immunosuppression mediated by an inhibitor of S-adenosyl-L-homocysteine hydrolase. Prevention and treatment of collagen-induced arthritis.
S-Adenosyl-L-homocysteine hydrolase inhibitor mediates immunosuppressive effects in vivo: suppression of delayed type hypersensitivity ear swelling and peptidoglycan polysaccharide-induced arthritis.
Arthritis, Experimental
Immunosuppression mediated by an inhibitor of S-adenosyl-L-homocysteine hydrolase. Prevention and treatment of collagen-induced arthritis.
Arthritis, Rheumatoid
Targeting methionine cycle as a potential therapeutic strategy for immune disorders.
Atherosclerosis
S-adenosyl-L-homocysteine hydrolase, key enzyme of methylation metabolism, regulates phosphatidylcholine synthesis and triacylglycerol homeostasis in yeast: implications for homocysteine as a risk factor of atherosclerosis.
Autoimmune Diseases
DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models.
Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-?/IFN-?-induced inflammatory response in keratinocytes and T cell-derived IL-17.
Brain Injuries
The early molecular processes underlying the neurological manifestations of an animal model of Wilson's disease.
Brain Injuries, Traumatic
DNA methylation of AHCY may increase the risk of ischemic stroke.
Breast Neoplasms
Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer.
S-adenosylhomocysteine hydrolase inhibition by 3-deazaneplanocin A analogues induces anti-cancer effects in breast cancer cell lines and synergy with both histone deacetylase and HER2 inhibition.
Carcinogenesis
Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma.
S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis.
Carcinoma
Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells.
Overexpression of S-adenosylhomocysteine hydrolase (SAHH) in esophageal squamous cell carcinoma (ESCC) cell lines: effects on apoptosis, migration and adhesion of cells.
Z-4',5'-didehydro-5'-deoxy-5'-fluoroadenosine (MDL 28,842), an irreversible inhibitor of S-adenosylhomocysteine hydrolase, suppresses proliferation of cultured keratinocytes and squamous carcinoma cell lines.
Carcinoma, Hepatocellular
Adult-onset liver disease and hepatocellular carcinoma in S-adenosylhomocysteine hydrolase deficiency.
Deficiency of S-adenosylmethionine-homocysteine methyltransferase activity in hepatoma cells.
Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma.
Metabolic perturbation of epigenome by inhibiting S-adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells.
Carcinoma, Squamous Cell
Z-4',5'-didehydro-5'-deoxy-5'-fluoroadenosine (MDL 28,842), an irreversible inhibitor of S-adenosylhomocysteine hydrolase, suppresses proliferation of cultured keratinocytes and squamous carcinoma cell lines.
Cardiomyopathies
S-adenosylhomocysteine hydrolase activity in human myocardium.
Chondrosarcoma
The Antitumoral Effect of the S-Adenosylhomocysteine Hydrolase Inhibitor, 3-Deazaneplanocin A, is Independent of EZH2 but is Correlated with EGFR Downregulation in Chondrosarcomas.
coagulation factor viia deficiency
Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency.
Colonic Neoplasms
Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Plasma biomarker identification in S-adenosylhomocysteine hydrolase deficiency.
cystathionine beta-synthase deficiency
Hydrogen sulfide intervention in cystathionine-?-synthase mutant mouse helps restore ocular homeostasis.
DNA Virus Infections
Highlights in the development of new antiviral agents.
Down Syndrome
DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase.
Mice Deficient in Cystathionine Beta Synthase Display Increased Dyrk1A and SAHH Activities in Brain.
Dwarfism
RNA-Seq and iTRAQ Reveal the Dwarfing Mechanism of Dwarf Polish Wheat (Triticum polonicum L.).
Encephalomyelitis
A reversible S-adenosyl-L-homocysteine hydrolase inhibitor ameliorates experimental autoimmune encephalomyelitis by inhibiting T cell activation.
Encephalomyelitis, Autoimmune, Experimental
A reversible S-adenosyl-L-homocysteine hydrolase inhibitor ameliorates experimental autoimmune encephalomyelitis by inhibiting T cell activation.
Epilepsy
E1 mice epilepsy shows genetic polymorphism for S-Adenosyl-L-homocysteine hydrolase.
Esophageal Squamous Cell Carcinoma
Overexpression of S-adenosylhomocysteine hydrolase (SAHH) in esophageal squamous cell carcinoma (ESCC) cell lines: effects on apoptosis, migration and adhesion of cells.
Factor VII Deficiency
Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency.
Filoviridae Infections
Antiviral drug therapy of filovirus infections: S-adenosylhomocysteine hydrolase inhibitors inhibit Ebola virus in vitro and in a lethal mouse model.
S-Adenosyl methionine/S-adenosyl-L-homocysteine ratio determination by capillary electrophoresis employed as a monitoring tool for the antiviral effectiveness of adenosine analogs.
Genetic Diseases, Inborn
S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism.
glycine n-methyltransferase deficiency
Inherited disorders in the conversion of methionine to homocysteine.
Heart Diseases
S-adenosylhomocysteine hydrolase activity in human myocardium.
Hemorrhagic Fever, Ebola
Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor.
Hepatitis B, Chronic
Inactivation of S-adenosylhomocysteine hydrolase during adenine arabinoside therapy.
Hepatitis C
Adenosylhomocysteinase like 1 interacts with nonstructural 5A and regulates hepatitis C virus propagation.
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives.
Hepatitis, Chronic
Plasma biomarker identification in S-adenosylhomocysteine hydrolase deficiency.
Hepatolenticular Degeneration
Wilson disease: Changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease.
HIV Infections
Highlights in the development of new antiviral agents.
Homocystinuria
Hydrogen sulfide intervention in cystathionine-?-synthase mutant mouse helps restore ocular homeostasis.
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Hydrops Fetalis
S-adenosylhomocysteine hydrolase deficiency: two siblings with fetal hydrops and fatal outcomes.
Hyperhomocysteinemia
Effect of lyophilized prune extract on hyperhomocysteinemia in mice.
Hydrogen sulfide intervention in cystathionine-?-synthase mutant mouse helps restore ocular homeostasis.
Nutri-epigenetics ameliorates blood-brain barrier damage and neurodegeneration in hyperhomocysteinemia: role of folic acid.
Reduced adenosine receptor stimulation as a pathogenic factor in hyperhomocysteinemia.
S-adenosyl-L-homocysteine hydrolase and methylation disorders: yeast as a model system.
Hypersensitivity
S-Adenosyl-L-homocysteine hydrolase inhibitor mediates immunosuppressive effects in vivo: suppression of delayed type hypersensitivity ear swelling and peptidoglycan polysaccharide-induced arthritis.
Hyperthyroidism
The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats.
Hypothyroidism
The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats.
hypoxanthine phosphoribosyltransferase deficiency
Decreased S-adenosylhomocysteine hydrolase in inborn errors of purine metabolism.
Immune System Diseases
Targeting methionine cycle as a potential therapeutic strategy for immune disorders.
Infections
Comparative inhibitory effects of nucleoside analogues on different clinical isolates of human cytomegalovirus in vitro.
Highlights in the development of new antiviral agents.
Immunization of mice with recombinant S-adenosyl-L-homocysteine hydrolase protein confers protection against Brucella melitensis infection.
Resistance against Ralstonia solanacearum in tomato depends on the methionine cycle and the ?-aminobutyric acid metabolic pathway.
Targeting methionine cycle as a potential therapeutic strategy for immune disorders.
Influenza, Human
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives.
Highlights in the development of new antiviral agents.
Synthesis and biological activity of unsaturated carboacyclic purine nucleoside analogues.
Iron Overload
Dietary supplementation with 3-deaza adenosine, N-acetyl cysteine, and S-adenosyl methionine provide neuroprotection against multiple consequences of vitamin deficiency and oxidative challenge: relevance to age-related neurodegeneration.
Ischemic Stroke
DNA methylation of AHCY may increase the risk of ischemic stroke.
Leishmaniasis, Visceral
Immunoprotective responses of Th1 stimulatory protein- S-Adenosyl-L-Homocysteine Hydrolase against Experimental visceral Leishmaniasis.
Lesch-Nyhan Syndrome
Decreased S-adenosylhomocysteine hydrolase in inborn errors of purine metabolism.
Leukemia
3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60.
4',5'-unsaturated 5'-halogenated nucleosides. Mechanism-based and competitive inhibitors of S-adenosyl-L-homocysteine hydrolase.
4'-Thioadenosine as a novel inhibitor of S-adenosylhomocysteine hydrolase and an inducer for the differentiation of HL-60 human leukemia cells.
Adenosine analogs as possible differentiation-inducing agents against acute myeloid leukemia.
Adenosylhomocysteine hydrolase inhibitors: synthesis of 5'-deoxy-5'-(isobutylthio)-3-deazaadenosine and its effect on Rous sarcoma virus and Gross murine leukemia virus.
Neplanocin A, a potent inhibitor of S-adenosylhomocysteine hydrolase, potentiates granulocytic differentiation of acute promyelocytic leukemia cells induced by all-trans retinoic acid.
Preliminary analysis of the protein profile in saliva during physiological term and preterm delivery.
Leukemia, Myeloid, Acute
Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells.
Leukemia, Promyelocytic, Acute
Neplanocin A, a potent inhibitor of S-adenosylhomocysteine hydrolase, potentiates granulocytic differentiation of acute promyelocytic leukemia cells induced by all-trans retinoic acid.
Liver Diseases
Adult-onset liver disease and hepatocellular carcinoma in S-adenosylhomocysteine hydrolase deficiency.
S-adenosylmethionine induces mitochondrial dysfunction, permeability transition pore opening and redox imbalance in subcellular preparations of rat liver.
Lung Neoplasms
DZNep, inhibitor of S-adenosylhomocysteine hydrolase, down-regulates expression of SETDB1 H3K9me3 HMTase in human lung cancer cells.
Lupus Erythematosus, Systemic
Targeting methionine cycle as a potential therapeutic strategy for immune disorders.
Lupus Nephritis
Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal ?-actinin-4 expression and stabilizing integrin-cytoskeleton linkage.
Lymphoma
Enhanced transcription of the s-adenosylhomocysteine hydrolase gene precedes Epstein-Barr virus lytic gene activation in ganglioside-stimulated lymphoma cells.
Selection and characterization of a murine lymphoid cell line partially deficient in S-adenosylhomocysteine hydrolase.
Lymphopenia
Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency.
Resistance of an adenosine kinase-deficient human lymphoblastoid cell line to effects of deoxyadenosine on growth, S-adenosylhomocysteine hydrolase inactivation, and dATP accumulation.
Malaria
Antimalarial activity of a 4',5'-unsaturated 5'-fluoroadenosine mechanism-based inhibitor of S-adenosyl-L-homocysteine hydrolase.
Crystal structure of S-adenosyl-L-homocysteine hydrolase from the human malaria parasite Plasmodium falciparum.
Crystallization and preliminary X-ray crystallographic analysis of Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase.
Docking and in silico ADMET studies of noraristeromycin, curcumin and its derivatives with Plasmodium falciparum SAH hydrolase: a molecular drug target against malaria.
Purification and properties of recombinant Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase.
S-Adenosyl-L-homocysteine hydrolase: Its Inhibitory Activity against Plasmodium falciparum and Development of Malaria Drugs.
Structural insight into binding mode of inhibitor with SAHH of Plasmodium and human: interaction of curcumin with anti-malarial drug targets.
Synthesis of carbocyclic nucleosides and their SAH hydrolase inhibitory activities.
Synthesis of S-adenosyl-L-homocysteine hydrolase inhibitors and their biological activities.
Three-dimensional structure of S-adenosyl-L-homocysteine hydrolase from Plasmodium falciparum.
[S-adenosyl-L-homocysteine hydrolase as an attractive target for antimicrobial drugs]
Mastocytoma
Purification and characterization of S-adenosylhomocysteine hydrolase from mouse mastocytoma P-815 cells. Evidence for cell cycle-specific fluctuation of the enzyme activity.
Metabolism, Inborn Errors
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Microcephaly
Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency.
Mitochondrial Diseases
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Multiple Sclerosis
Targeting methionine cycle as a potential therapeutic strategy for immune disorders.
Muscular Diseases
Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency.
Plasma biomarker identification in S-adenosylhomocysteine hydrolase deficiency.
Neoplasms
3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation.
3-Deazaneplanocin A (DZNep), an inhibitor of the histone methyltransferase EZH2, induces apoptosis and reduces cell migration in chondrosarcoma cells.
Antiproliferative and Antimigration Activities of Fluoro-Neplanocin A via Inhibition of Histone H3 Methylation in Triple-Negative Breast Cancer.
Deazaneplanocin a is a promising drug to kill multiple myeloma cells in their niche.
DNA (cytosine) methylation in murine and human tumor cell lines treated with S-adenosylhomocysteine hydrolase inhibitors.
EZH2 is essential for glioblastoma cancer stem cell maintenance.
Identification of novel dioxin-responsive genes by representational difference analysis.
Identification of S100A8 and S100A9 as Serological Markers for Colorectal Cancer.
Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest.
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells.
Resistance to inhibitors of S-adenosyl-L-homocysteine hydrolase in C1300 murine neuroblastoma tumor cells is associated with increased methionine adenosyltransferase activity.
S-Adenosyl-L-homocysteine hydrolase: Its Inhibitory Activity against Plasmodium falciparum and Development of Malaria Drugs.
Suppression of C-1300 murine neuroblastoma cell proliferation in tissue culture and tumor growth in vivo by (Z)5'-fluoro-4',5'-didehydro-5'-deoxyadenosine (MDL 28,842), an irreversible inhibitor of S-adenosyl-L-homocysteine hydrolase.
Synthesis and biological evaluation of a carbocyclic azanoraristeromycin siderophore conjugate.
Neuroblastoma
Adenosine dialdehyde and neplanocin A: Potent inhibitors of S-adenosylhomocysteine hydrolase in neuroblastoma N2a cells.
Effect of adenosine analogues on protein carboxylmethyltransferase, S-adenosylhomocysteine hydrolase, and ribonucleotide reductase activity in murine neuroblastoma cells.
Mitogen-activated protein kinase signaling in drug-resistant neuroblastoma cells.
Resistance to inhibitors of S-adenosyl-L-homocysteine hydrolase in C1300 murine neuroblastoma tumor cells is associated with increased methionine adenosyltransferase activity.
S-adenosylmethionine synthetase is overexpressed in murine neuroblastoma cells resistant to nucleoside analogue inhibitors of S-adenosylhomocysteine hydrolase: a novel mechanism of drug resistance.
Suppression of C-1300 murine neuroblastoma cell proliferation in tissue culture and tumor growth in vivo by (Z)5'-fluoro-4',5'-didehydro-5'-deoxyadenosine (MDL 28,842), an irreversible inhibitor of S-adenosyl-L-homocysteine hydrolase.
Neurologic Manifestations
Proteomic analysis of the hepatic tissue of Long-Evans Cinnamon (LEC) rats according to the natural course of Wilson disease.
Neuronal Ceroid-Lipofuscinoses
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Niemann-Pick Diseases
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Non-alcoholic Fatty Liver Disease
Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma.
Osteoarthritis
Anti-inflammatory and chondroprotective effects of the S-adenosylhomocysteine hydrolase inhibitor 3-Deazaneplanocin A, in human articular chondrocytes.
Ovarian Neoplasms
Synergy between cisplatin and an inhibitor of S-adenosylmethionine dependent transmethylation in human ovarian adenocarcinoma cells.
Pancreatic Neoplasms
Inhibition of S-Adenosylmethionine-Dependent Methyltransferase Attenuates TGF-beta1-induced EMT and Metastasis in Pancreatic Cancer: Putative Roles of miR-663a and miR-4787-5p.
Paramyxoviridae Infections
New neplanocin analogues. 6. Synthesis and potent antiviral activity of 6'-homoneplanocin A1.
New neplanocin analogues. 7. Synthesis and antiviral activity of 2-halo derivatives of neplanocin A.
Synthesis and biological evaluation of a carbocyclic azanoraristeromycin siderophore conjugate.
Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.
phosphomannomutase deficiency
Clinical picture of S-adenosylhomocysteine hydrolase deficiency resembles phosphomannomutase 2 deficiency.
Picornaviridae Infections
Highlights in the development of new antiviral agents.
Plasmacytoma
Reactivation of S-adenosylhomocysteine hydrolase activity in cells exposed to 9-beta-D-arabinofuranosyladenine.
Porphyrias
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Poxviridae Infections
John Montgomery's legacy: carbocyclic adenosine analogues as SAH hydrolase inhibitors with broad-spectrum antiviral activity.
Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives.
purine-nucleoside phosphorylase deficiency
Decreased S-adenosylhomocysteine hydrolase in inborn errors of purine metabolism.
Proposed explanation for S-adenosylhomocysteine hydrolase deficiency in purine nucleoside phosphorylase and hypoxanthine-guanine phosphoribosyltransferase-deficient patients.
Sarcoma
Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells.
Sarcoma 180
Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells.
Sarcoma, Avian
3-Deazaadenosine, an inhibitor of adenosylhomocysteine hydrolase, inhibits reproduction of Rous sarcoma virus and transformation of chick embryo cells.
Adenosylhomocysteine hydrolase inhibitors: synthesis of 5'-deoxy-5'-(isobutylthio)-3-deazaadenosine and its effect on Rous sarcoma virus and Gross murine leukemia virus.
Selective inhibition of avian sarcoma virus protein synthesis in 3-deazaadenosine-treated infected chicken embryo fibroblasts.
Scleroderma, Systemic
Targeting methionine cycle as a potential therapeutic strategy for immune disorders.
Seizures
Down-regulation of S-adenosylhomocysteine hydrolase in the active methyl transfer system in the brain of genetically epileptic El mice.
Severe Combined Immunodeficiency
S-adenosylhomocysteine hydrolase activity in horses, Equus cabalus, with severe combined immunodeficiency.
Smallpox
John Montgomery's legacy: carbocyclic adenosine analogues as SAH hydrolase inhibitors with broad-spectrum antiviral activity.
Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives.
Tuberculosis
Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Mycobacterium tuberculosis AtsG (Rv0296c), GlmU (Rv1018c) and SahH (Rv3248c) Proteins Function as the Human IL-8-Binding Effectors and Contribute to Pathogen Entry into Human Neutrophils.
Mycobacterium tuberculosis S-adenosyl-l-homocysteine hydrolase is negatively regulated by Ser/Thr phosphorylation.
Regulation of homocysteine metabolism by Mycobacterium tuberculosis S-adenosylhomocysteine hydrolase.
Urea Cycle Disorders, Inborn
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Vaccinia
9-(trans-2',trans-3'-Dihydroxycyclopent-4'-enyl)-adenine and -3-deazaadenine: analogs of neplanocin A which retain potent antiviral activity but exhibit reduced cytotoxicity.
Homocysteine potentiates the antiviral and cytostatic activity of those nucleoside analogues that are targeted at S-adenosylhomocysteine hydrolase.
Influence of S-adenosylhomocysteine hydrolase inhibitors on S-adenosylhomocysteine and S-adenosylmethionine pool levels in L929 cells.
Neplanocin A. A potent inhibitor of S-adenosylhomocysteine hydrolase and of vaccinia virus multiplication in mouse L929 cells.
New neplanocin analogues. 6. Synthesis and potent antiviral activity of 6'-homoneplanocin A1.
New neplanocin analogues. 7. Synthesis and antiviral activity of 2-halo derivatives of neplanocin A.
New neplanocin analogues. VIII. Synthesis and biological activity of 6'-C-ethyl, -ethenyl, and -ethynyl derivatives of neplanocin A.
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 11. Molecular dissections of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase.
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 8. Molecular dissections of carbocyclic 3-deazaadenosine as inhibitors of S-adenosylhomocysteine hydrolase.
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 9. 2',3'-Dialdehyde derivatives of carbocyclic purine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase.
Synthesis and biological evaluation of a carbocyclic azanoraristeromycin siderophore conjugate.
Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.
[Synthesis and antiviral evaluation against Vaccinia virus of new N¹-oxide analogues of 5'-noraristeromycin].
Venous Thrombosis
Effect of genetic variation in the human S-adenosylhomocysteine hydrolase gene on total homocysteine concentrations and risk of recurrent venous thrombosis.
Vesicular Stomatitis
Antiviral potency of adenosine analogues: correlation with inhibition of S-adenosylhomocysteine hydrolase.
Homocysteine potentiates the antiviral and cytostatic activity of those nucleoside analogues that are targeted at S-adenosylhomocysteine hydrolase.
Influence of S-adenosylhomocysteine hydrolase inhibitors on S-adenosylhomocysteine and S-adenosylmethionine pool levels in L929 cells.
New neplanocin analogues. 6. Synthesis and potent antiviral activity of 6'-homoneplanocin A1.
New neplanocin analogues. 7. Synthesis and antiviral activity of 2-halo derivatives of neplanocin A.
New neplanocin analogues. VIII. Synthesis and biological activity of 6'-C-ethyl, -ethenyl, and -ethynyl derivatives of neplanocin A.
Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.
Virus Diseases
Adenosine dialdehyde: a potent inhibitor of vaccinia virus multiplication in mouse L929 cells.
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives.
Hamao Umezawa Memorial Award Lecture: "An Odyssey in the Viral Chemotherapy Field".
Highlights in the development of new antiviral agents.
John Montgomery's legacy: carbocyclic adenosine analogues as SAH hydrolase inhibitors with broad-spectrum antiviral activity.
S-Adenosyl-L-homocysteine hydrolase: Its Inhibitory Activity against Plasmodium falciparum and Development of Malaria Drugs.
Vitamin B 12 Deficiency
Effects of the disruption of transmethylation in the central nervous system: an animal model.
Vitamin B 6 Deficiency
Effect of vitamin B6 deficiency on S-adenosylhomocysteine hydrolase activity as a target point for methionine metabolic regulation.
Xanthomatosis, Cerebrotendinous
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Yellow Fever
Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.