Disease on EC 3.2.2.5 - NAD+ glycohydrolase
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nad+ glycohydrolase deficiency
[Contribution and limits of CD157 in the detection of the paroxysmal nocturnal hemoglobinuria clone: a case report].
Adenocarcinoma
Expression of NAD glycohydrolase activity by rat mammary adenocarcinoma cells transformed with rat T cell alloantigen RT6.2.
Anaphylaxis
The inhibition of mast cell damage and histamine release in anaphylaxis by pyridine and diphosphopyridine nucleotidase inhibitors. Comparison with compound 48/80.
Anemia
[Contribution and limits of CD157 in the detection of the paroxysmal nocturnal hemoglobinuria clone: a case report].
Arrhythmias, Cardiac
Selective inhibitors of cardiac ADPR cyclase as novel anti-arrhythmic compounds.
Arthritis, Rheumatoid
The NADase enzyme CD38: an emerging pharmacological target for systemic sclerosis, systemic lupus erythematosus and rheumatoid arthritis.
Bacterial Infections
CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production.
Brain Ischemia
CD157 and Brain Immune System in (Patho)physiological Conditions: Focus on Brain Plasticity.
Carcinoma
Increase of NAD glycohydrolase activity in uterine cervix cancers is caused by infiltration of lymphocytes.
Carcinoma, Ehrlich Tumor
A relation between pyridine nucleotide-dependent dehydrogenase activity and nicotinamide adenine dinucleotide glycohydrolase in Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Identity of nuclear NAD nucleosidase with a polyADP-ribose forming enzyme in Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Relationship of the nicotinamide adenine dinucleotide glycohydrolase activity to nicotinamide adenine dinucleotide content and rate of proliferation of Ehrlich ascites tumor cells.
Carcinoma, Ovarian Epithelial
CD157 at the intersection between leukocyte trafficking and epithelial ovarian cancer invasion.
Carcinoma, Ovarian Epithelial
CD157: From immunoregulatory protein to potential therapeutic target.
Carcinoma, Ovarian Epithelial
Functional role and prognostic significance of CD157 in ovarian carcinoma.
Carcinoma, Ovarian Epithelial
Overexpression of CD157 Contributes to Epithelial Ovarian Cancer Progression by Promoting Mesenchymal Differentiation.
Cholera
Inhibition of ADP-ribosyltransferase activity of cholera toxin by MDL 12330A and chlorpromazine.
Cholera
NAD-glycohydrolase activity of botulinum C2 toxin: a possible role of component I in the mode of action of the toxin.
Colorectal Neoplasms
Clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer.
Diabetes Mellitus, Type 2
A cloned rat CD38-homologous protein and its expression in pancreatic islets.
Diphtheria
Effect of gangliosides and substrate analogues on the hydrolysis of nicotinamide adenine dinucleotide by choleragen.
Diphtheria
NAD-glycohydrolase activity of botulinum C2 toxin: a possible role of component I in the mode of action of the toxin.
Encephalomyelitis, Autoimmune, Experimental
[Redox-state of NAD pairs and activity of lactatedehydrogenase and NADase in guinea pig tissues at different stages of development of experimental allergic encephalomyelitis]
Fasciitis, Necrotizing
Characterization of the NAD-glycohydrolase in streptococcal strains.
Foodborne Diseases
Time course of virulence factors produced by group A streptococcus during a food-borne epidemic.
Glioma
Activation by thiol of the latent NAD glycohydrolase and ADP-ribosyltransferase activities of Bordetella pertussis toxin (islet-activating protein).
Gliosarcoma
Cellular regulation of poly(ADP) ribosylation of proteins. I. Comparison of hepatocytes, cultured cells and liver nuclei and the influence of varying concentrations of NAD.
Glomerulonephritis
Extracellular factors, blood group antigens, and bacteriophage of nephritogenic and nonnephritogenic strains of M-type 12 streptococci.
Heart Arrest
Selective inhibitors of cardiac ADPR cyclase as novel anti-arrhythmic compounds.
Hemoglobinuria
Clinical relevance of CD157 for rapid and cost-effective simultaneous evaluation of PNH granulocytes and monocytes by flow cytometry.
Hemoglobinuria
Diagnosis of paroxysmal nocturnal hemoglobinuria with flowcytometry panels including CD157: Data from the real world.
Hemoglobinuria
Erythrocyte diphosphopyridine nucleotidase (NADase) in paroxysmal nocturnal hemoglobinuria.
Hemoglobinuria
Performance characteristics of a non-fluorescent aerolysin-based paroxysmal nocturnal hemoglobinuria (PNH) assay for simultaneous evaluation of PNH neutrophils and PNH monocytes by flow cytometry, following published PNH guidelines.
Hemoglobinuria
The Monoclonal Anti-CD157 Antibody Clone SY11B5, Used for High Sensitivity Detection of PNH Clones on WBCs, Fails to Detect a Common Polymorphic Variant Encoded by BST-1.
Hemoglobinuria
Utility of CD157 as a Common Leukocytes Marker for Paroxysmal Nocturnal Hemoglobinuria Screening in a Single Tube Five Color Combination.
Hemoglobinuria
Utility of FLAER and CD157 in a five-color single-tube high sensitivity assay, for diagnosis of Paroxysmal Nocturnal Hemoglobinuria (PNH)-A standalone flow cytometry laboratory experience.
Hemoglobinuria
[Contribution and limits of CD157 in the detection of the paroxysmal nocturnal hemoglobinuria clone: a case report].
Hemoglobinuria, Paroxysmal
CD157 is an important mediator of neutrophil adhesion and migration.
Hemoglobinuria, Paroxysmal
Clinical relevance of CD157 for rapid and cost-effective simultaneous evaluation of PNH granulocytes and monocytes by flow cytometry.
Hemoglobinuria, Paroxysmal
Diagnosis of paroxysmal nocturnal hemoglobinuria with flowcytometry panels including CD157: Data from the real world.
Hemoglobinuria, Paroxysmal
Erythrocyte diphosphopyridine nucleotidase (NADase) in paroxysmal nocturnal hemoglobinuria.
Hemoglobinuria, Paroxysmal
Performance characteristics of a non-fluorescent aerolysin-based paroxysmal nocturnal hemoglobinuria (PNH) assay for simultaneous evaluation of PNH neutrophils and PNH monocytes by flow cytometry, following published PNH guidelines.
Hemoglobinuria, Paroxysmal
The Monoclonal Anti-CD157 Antibody Clone SY11B5, Used for High Sensitivity Detection of PNH Clones on WBCs, Fails to Detect a Common Polymorphic Variant Encoded by BST-1.
Hemoglobinuria, Paroxysmal
Utility of CD157 as a Common Leukocytes Marker for Paroxysmal Nocturnal Hemoglobinuria Screening in a Single Tube Five Color Combination.
Hemoglobinuria, Paroxysmal
Utility of FLAER and CD157 in a five-color single-tube high sensitivity assay, for diagnosis of Paroxysmal Nocturnal Hemoglobinuria (PNH)-A standalone flow cytometry laboratory experience.
Hemoglobinuria, Paroxysmal
[Contribution and limits of CD157 in the detection of the paroxysmal nocturnal hemoglobinuria clone: a case report].
Infections
Binding of NAD(+)-Glycohydrolase to Streptolysin O Stabilizes Both Toxins and Promotes Virulence of Group A Streptococcus.
Infections
CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production.
Infections
Contribution of Secreted NADase and Streptolysin O to the Pathogenesis of Epidemic Serotype M1 Streptococcus pyogenes Infections.
Infections
Inhibition of Inflammasome-Dependent Interleukin 1? Production by Streptococcal NAD(+)-Glycohydrolase: Evidence for Extracellular Activity.
Infections
Intergenic Variable-Number Tandem-Repeat Polymorphism Upstream of rocA Alters Toxin Production and Enhances Virulence in Streptococcus pyogenes.
Infections
Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase.
Infections
Molecular epidemiology of nga and NAD glycohydrolase/ADP-ribosyltransferase activity among Streptococcus pyogenes causing streptococcal toxic shock syndrome.
Infections
NADase as a target molecule of in vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates.
Infections
Pathogen induced subversion of NAD+ metabolism mediating host cell death: a target for development of chemotherapeutics.
Infections
Role of NADase in virulence in experimental invasive group A streptococcal infection.
Infections
Streptolysin O and NAD-glycohydrolase prevent phagolysosome acidification and promote group A Streptococcus survival in macrophages.
Infections
The Secreted Virulence Factor NADase of Group A Streptococcus Inhibits P2X7 Receptor-Mediated Release of IL-1?.
Infections
Tissue metabolism in infection. DPNase activity, DPN levels, and DPN-linked dehydrogenases in tissues from normal and tuberculous mice.
Leukemia
Induction by retinoic acid of NAD+-glycohydrolase activity of myelomonocytic cell lines HL-60, THP-1 and U-937, and fresh human acute promyelocytic leukemia cells in primary culture.
Leukemia
Induction of CD38/NADase and its monoclonal antibody-induced tyrosine phosphorylation in human leukemia cell lines.
Leukemia, Lymphocytic, Chronic, B-Cell
Nad+ metabolism in lymphocytes of patients affected by B-cell chronic lymphocytic leukaemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Upregulation of CD38 gene expression in leukemic B cells by interferon types I and II.
Leukemia, Myeloid, Acute
CD157: From Myeloid Cell Differentiation Marker to Therapeutic Target in Acute Myeloid Leukemia.
Leukemia, Promyelocytic, Acute
Induction by retinoic acid of NAD+-glycohydrolase activity of myelomonocytic cell lines HL-60, THP-1 and U-937, and fresh human acute promyelocytic leukemia cells in primary culture.
Liver Diseases
Serum NAD glycohydrolase activities in normal subjects and in patients with chronic liver diseases.
Lung Neoplasms
CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production.
Lupus Erythematosus, Systemic
The NADase enzyme CD38: an emerging pharmacological target for systemic sclerosis, systemic lupus erythematosus and rheumatoid arthritis.
Lymphoma
An 18-kDa domain of a glycosylphosphatidylinositol-linked NAD:arginine ADP-ribosyltransferase possesses NAD glycohydrolase activity.
Lymphoma
Modification of the ADP-ribosyltransferase and NAD glycohydrolase activities of a mammalian transferase (ADP-ribosyltransferase 5) by auto-ADP-ribosylation.
Mesothelioma
CD157 enhances malignant pleural mesothelioma aggressiveness and predicts poor clinical outcome.
Mesothelioma, Malignant
CD157 enhances malignant pleural mesothelioma aggressiveness and predicts poor clinical outcome.
Mesothelioma, Malignant
Soluble CD157 in pleural effusions: a complementary tool for the diagnosis of malignant mesothelioma.
Neoplasm Metastasis
CD157 at the intersection between leukocyte trafficking and epithelial ovarian cancer invasion.
Neoplasm Metastasis
The Roles of CD38 and CD157 in the Solid Tumor Microenvironment and Cancer Immunotherapy.
Neoplasms
A relation between pyridine nucleotide-dependent dehydrogenase activity and nicotinamide adenine dinucleotide glycohydrolase in Ehrlich ascites tumor cells.
Neoplasms
Biochemical changes in tumor cells caused by antitumor agents. I. Effects of several antitumor agents on NAD content and NAD-glycohydrolase activity in Yoshida sarcoma cells and rat liver.
Neoplasms
CD157 at the intersection between leukocyte trafficking and epithelial ovarian cancer invasion.
Neoplasms
CD157 enhances malignant pleural mesothelioma aggressiveness and predicts poor clinical outcome.
Neoplasms
CD157: From Myeloid Cell Differentiation Marker to Therapeutic Target in Acute Myeloid Leukemia.
Neoplasms
Clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer.
Neoplasms
Effects of extracts of normal tissues and of tumours on yeast fermentation; estimations of relative diphosphopyridine nucleosidase activities.
Neoplasms
Identity of nuclear NAD nucleosidase with a polyADP-ribose forming enzyme in Ehrlich ascites tumor cells.
Neoplasms
Increase in RNase and DPNase activities in ascites tumor cells induced by various cytostatic agents.
Neoplasms
Increase of NAD glycohydrolase activity in uterine cervix cancers is caused by infiltration of lymphocytes.
Neoplasms
NAD glycohydrolase activities and ADP-ribose uptake in erythrocytes from normal subjects and cancer patients.
Neoplasms
Nicotinamide adenine dinucleotide glycohydrolase in normal & tumor tissues of plants cultivated in vitro.
Neoplasms
Overexpression of CD157 Contributes to Epithelial Ovarian Cancer Progression by Promoting Mesenchymal Differentiation.
Neoplasms
Relationship of the nicotinamide adenine dinucleotide glycohydrolase activity to nicotinamide adenine dinucleotide content and rate of proliferation of Ehrlich ascites tumor cells.
Neoplasms
Serum proteins with NAD+ glycohydrolase activity and anti-CD38 reactivity--elevated levels in serum of tumour patients.
Neoplasms
The Roles of CD38 and CD157 in the Solid Tumor Microenvironment and Cancer Immunotherapy.
Neoplasms
[THE DECISIVE SIGNIFICANCE OF DPNASE ACTIVATION FOR DPN DEGRADATION IN IRRADIATED ASCITES TUMOR CELLS.]
Nervous System Diseases
Gene therapy targeting SARM1 blocks pathological axon degeneration in mice.
Neuroblastoma
Activation by thiol of the latent NAD glycohydrolase and ADP-ribosyltransferase activities of Bordetella pertussis toxin (islet-activating protein).
Neuroinflammatory Diseases
CD157 and Brain Immune System in (Patho)physiological Conditions: Focus on Brain Plasticity.
Obesity
The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity.
Ovarian Neoplasms
CD157 at the intersection between leukocyte trafficking and epithelial ovarian cancer invasion.
Ovarian Neoplasms
CD157 enhances malignant pleural mesothelioma aggressiveness and predicts poor clinical outcome.
Ovarian Neoplasms
Functional role and prognostic significance of CD157 in ovarian carcinoma.
Ovarian Neoplasms
Overexpression of CD157 Contributes to Epithelial Ovarian Cancer Progression by Promoting Mesenchymal Differentiation.
Parkinson Disease
An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator.
Parkinson Disease
Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease.
Parkinson Disease
Lipo-oxytocin-1, a Novel Oxytocin Analog Conjugated with Two Palmitoyl Groups, Has Long-Lasting Effects on Anxiety-Related Behavior and Social Avoidance in CD157 Knockout Mice.
Pharyngitis
Extracellular factors, blood group antigens, and bacteriophage of nephritogenic and nonnephritogenic strains of M-type 12 streptococci.
Pharyngitis
Serum inhibition of streptococcal diphosphopyridine nucleotidase in uncomplicated streptococcal pharyngitis and in rheumatic fever.
Pharyngitis
Streptolysin O and its co-toxin NAD-glycohydrolase protect group A Streptococcus from Xenophagic killing.
Pleural Effusion
Soluble CD157 in pleural effusions: a complementary tool for the diagnosis of malignant mesothelioma.
Pneumonia
CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production.
Rheumatic Fever
Serum inhibition of streptococcal diphosphopyridine nucleotidase in uncomplicated streptococcal pharyngitis and in rheumatic fever.
Sarcoma
Biochemical changes in tumor cells caused by antitumor agents. I. Effects of several antitumor agents on NAD content and NAD-glycohydrolase activity in Yoshida sarcoma cells and rat liver.
Sarcoma, Yoshida
Biochemical changes in tumor cells caused by antitumor agents. I. Effects of several antitumor agents on NAD content and NAD-glycohydrolase activity in Yoshida sarcoma cells and rat liver.
Schistosomiasis
Efficient Inhibition of SmNACE by Coordination Complexes Is Abolished by S. mansoni Sequestration of Metal.
Scleroderma, Systemic
The NADase enzyme CD38: an emerging pharmacological target for systemic sclerosis, systemic lupus erythematosus and rheumatoid arthritis.
Seizures
Proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy: potential targets in calcium regulatory network.
Sepsis
Role of NADase in virulence in experimental invasive group A streptococcal infection.
Spinal Cord Injuries
CD157 in bone marrow mesenchymal stem cells mediates mitochondrial production and transfer to improve neuronal apoptosis and functional recovery after spinal cord injury.
Streptococcal Infections
Role of NADase in virulence in experimental invasive group A streptococcal infection.
Streptococcal Infections
[Studies on the diagnostic significance of serum anti-streptococcal diphosphopyridine nucleotidase in streptococcal infections. 2. Its values in various pediatric diseases]
Tuberculosis
CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production.
Tuberculosis
Comparative study of nicotinamide adenine dinucleotide nucleosidase from Mycobacterium tuberculosis H37Rv & pig brain: effect of isonicotinic acid hydrazide on the enzyme-inhibitor complex.
Tuberculosis
Isoniazid-resistant mutants of Mycobacterium tuberculosis H37RV: uptake of isoniazid and the properties of NADase inhibitor.
Tuberculosis
Mycobacterium tuberculosis Toxin CpnT Is an ESX-5 Substrate and Requires Three Type VII Secretion Systems for Intracellular Secretion.
Tuberculosis
Pathogen induced subversion of NAD+ metabolism mediating host cell death: a target for development of chemotherapeutics.
Tuberculosis
[Alteration in activities of NAD-glycohydrolase, acid and alkaline phosphatases in blood cells tuberculosis]
Tuberculosis, Pleural
CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production.
Uterine Cervical Neoplasms
Increase of NAD glycohydrolase activity in uterine cervix cancers is caused by infiltration of lymphocytes.
Ventricular Fibrillation
Selective inhibitors of cardiac ADPR cyclase as novel anti-arrhythmic compounds.
Whooping Cough
Activation by thiol of the latent NAD glycohydrolase and ADP-ribosyltransferase activities of Bordetella pertussis toxin (islet-activating protein).
Whooping Cough
Alkylation of cysteine 41, but not cysteine 200, decreases the ADP-ribosyltransferase activity of the S1 subunit of pertussis toxin.
Whooping Cough
Amino acid-specific ADP-ribosylation: structural characterization and chemical differentiation of ADP-ribose-cysteine adducts formed nonenzymatically and in a pertussis toxin-catalyzed reaction.
Whooping Cough
Development of opiate receptors and GTP-binding regulatory proteins in neonatal rat brain.
Whooping Cough
Effect of temperature and host factors on the activities of pertussis toxin and Bordetella adenylate cyclase.
Whooping Cough
Evidence for a catalytic role of glutamic acid 129 in the NAD-glycohydrolase activity of the pertussis toxin S1 subunit.
Whooping Cough
Involvement of pertussis toxin-sensitive mechanism in retinoic acid-induced differentiation of human leukemic HL-60 cells.
Whooping Cough
Localization of a region of the S1 subunit of pertussis toxin required for efficient ADP-ribosyltransferase activity.
Whooping Cough
Monoclonal antibodies against the enzymatic subunit of both pertussis and cholera toxins.
Whooping Cough
Monoclonal antibodies that inhibit ADP-ribosyltransferase but not NAD-glycohydrolase activity of pertussis toxin.
Whooping Cough
Role of tryptophan 26 in the NAD glycohydrolase reaction of the S-1 subunit of pertussis toxin.
Whooping Cough
Stimulation of the thiol-dependent ADP-ribosyltransferase and NAD glycohydrolase activities of Bordetella pertussis toxin by adenine nucleotides, phospholipids, and detergents.
Whooping Cough
Sulfhydryl-alkylating reagents inactivate the NAD glycohydrolase activity of pertussis toxin.
Whooping Cough
The NAD-glycohydrolase activity of the pertussis toxin S1 subunit. Involvement of the catalytic HIS-35 residue.
Whooping Cough
The purification of a cysteine-dependent NAD+ glycohydrolase activity from bovine erythrocytes and evidence that it exhibits a novel ADP-ribosyltransferase activity.
Whooping Cough
The role of cysteine 41 in the enzymatic activities of the pertussis toxin S1 subunit as investigated by site-directed mutagenesis.
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