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DNA containing a 5-hydroxyuracil/adenine mismatch + H2O
?
-
the enzyme has a moderate affinity for DNA containing a 5-hydroxyuracil/adenine mismatch
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mispair + H2O
?
-
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:guanine mismatch + H2O
?
-
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:thymine mismatch + H2O
?
-
low activity
-
-
?
DNA containing a cytosine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a cytosine:adenine mispair + H2O
?
-
-
-
-
?
DNA containing a guanine:adenine mismatch + H2O
?
DNA containing a guanine:adenine mispair + H2O
?
-
-
-
-
?
DNA containing a thymine:guanine mismatch + H2O
?
-
low activity
-
-
?
DNA containing an adenine:7,8-dihydro-8-oxoadenine mismatch + H2O
?
-
-
-
-
?
DNA containing an adenine:7,8-dihydro-8-oxoadenine mismatch + H2O
adenine + DNA with apurinic site
DNA containing an adenine:7,8-dihydro-8-oxoguanine mismatch + H2O
?
DNA containing an adenine:7,8-dihydro-8-oxoguanine mispair + H2O
DNA containing an abasic site + adenine
-
primary substrate in vivo
-
-
?
DNA containing an adenine:8-oxoguanine mismatch + H2O
?
-
-
-
?
DNA containing an adenine:cytosine mismatch + H2O
?
-
-
-
-
?
DNA containing an adenine:guanine mismatch + H2O
?
DNA containing an adenine:guanine mismatch + H2O
adenine + DNA with apurinic site
additional information
?
-
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
highest activity
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
the enzyme shows 6fold faster adenine removal compared to DNA containing a guanine:adenine mismatch. However, under conditions where the concentration of the enzyme is much lower than the concentration of DNA, 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine substrates are not quantitatively converted to product due to the inefficient turnover resulting from slow product release
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a guanine:adenine mismatch + H2O
?
-
-
744292, 744587, 745259, 745265, 745269, 745274, 745393, 745909, 745911, 745912, 745913, 746329 -
-
?
DNA containing a guanine:adenine mismatch + H2O
?
-
-
-
?
DNA containing a guanine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a guanine:adenine mismatch + H2O
?
-
-
-
?
DNA containing a guanine:adenine mismatch + H2O
?
-
-
-
?
DNA containing a guanine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a guanine:adenine mismatch + H2O
?
-
-
-
?
DNA containing a guanine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing an adenine:7,8-dihydro-8-oxoadenine mismatch + H2O
adenine + DNA with apurinic site
-
-
-
-
?
DNA containing an adenine:7,8-dihydro-8-oxoadenine mismatch + H2O
adenine + DNA with apurinic site
-
-
-
-
?
DNA containing an adenine:7,8-dihydro-8-oxoadenine mismatch + H2O
adenine + DNA with apurinic site
-
-
-
-
?
DNA containing an adenine:7,8-dihydro-8-oxoguanine mismatch + H2O
?
-
-
-
?
DNA containing an adenine:7,8-dihydro-8-oxoguanine mismatch + H2O
?
very high specificity
-
-
?
DNA containing an adenine:guanine mismatch + H2O
?
-
-
-
-
?
DNA containing an adenine:guanine mismatch + H2O
?
-
-
-
?
DNA containing an adenine:guanine mismatch + H2O
adenine + DNA with apurinic site
-
-
-
-
?
DNA containing an adenine:guanine mismatch + H2O
adenine + DNA with apurinic site
-
-
-
-
?
DNA containing an adenine:guanine mismatch + H2O
adenine + DNA with apurinic site
-
-
-
-
?
additional information
?
-
-
no activity with DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:cytosine mismatch
-
-
?
additional information
?
-
-
the enzyme catalyzes the removal of adenine bases mispaired with 2'-deoxyguanosine and 7,8-dihydro-8-oxo-2'-deoxyguanosine in DNA
-
-
?
additional information
?
-
the enzyme is specific for adenine removal from 7,8-dihydro-8-oxoguanine:adenine as well as guanine:adenine, and cytosine:adenine mispairs in double-stranded DNA
-
-
?
additional information
?
-
-
the enzyme is specific for adenine removal from 7,8-dihydro-8-oxoguanine:adenine as well as guanine:adenine, and cytosine:adenine mispairs in double-stranded DNA
-
-
?
additional information
?
-
-
no activity with DNA containing 2'-deoxy-2'-fluoroadenosine, 2'-deoxyaristeromycin, and 2'-deoxyformycin A opposite either guanine or 7,8-dihydro-8-oxo-2'-deoxyguanosine
-
-
?
additional information
?
-
-
no activity with DNA containing a adenine:cytosine mismatch, guanine:thymine mismatch, cytosine:thymine mismatch, or guanine:guanine mismatch
-
-
?
additional information
?
-
-
no activity with DNA containing a guanine:guanine mismatch
-
-
?
additional information
?
-
-
no activity with DNA containing an cytosine:7,8-dihydro-8-oxoguanine mismatch
-
-
?
additional information
?
-
-
no activity with DNA containing tetrahydrofuran nucleotide, 2'-deoxyformycin, 2'-deoxy-2'-fluoroadenosine, 4-methylindole beta-deoxynucleoside, purine 2'-deoxynucleoside, and 2'-deoxycytifinde opposite either guanine or 7,8-dihydro-8-oxo-2'-deoxyguanosine
-
-
?
additional information
?
-
substrate recognition is evaluated using a DNA duplex containing a 2'-deoxyadenosine analog in a base pair opposite guanine or 7,8-dihydro-8-oxoguanine
-
-
?
additional information
?
-
-
substrate recognition is evaluated using a DNA duplex containing a 2'-deoxyadenosine analog in a base pair opposite guanine or 7,8-dihydro-8-oxoguanine
-
-
?
additional information
?
-
the enzyme has no activity with 2'-deoxyaristeromycin, 2'-deoxy-2'-fluoroadenosine, and 2'-deoxyformycin A
-
-
?
additional information
?
-
-
the enzyme has no activity with 2'-deoxyaristeromycin, 2'-deoxy-2'-fluoroadenosine, and 2'-deoxyformycin A
-
-
?
additional information
?
-
the enzyme has no activity with DNA containing 2'-deoxyfluoroadenosine
-
-
?
additional information
?
-
-
the enzyme recognizes but shows no enzymatic activity with the 2'-deoxyadenosine analogs 2'-deoxytubercidin and 2'-deoxyformycin A
-
-
?
additional information
?
-
-
the enzyme does not excise adenine when it is paired with cyclobutane pyrimidine dimer and pyrimidine (6-4) pyrimidone photoproduct adducts in duplex DNA
-
-
?
additional information
?
-
no activity with DNA containing a cytosine:8-oxoguanine mismatch
-
-
?
additional information
?
-
-
the enzyme shows no activity with DNA containing a guanine:adenine mismatch
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mispair + H2O
?
-
-
-
-
?
DNA containing a cytosine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a guanine:adenine mismatch + H2O
?
DNA containing an adenine:7,8-dihydro-8-oxoadenine mismatch + H2O
adenine + DNA with apurinic site
DNA containing an adenine:7,8-dihydro-8-oxoguanine mismatch + H2O
?
very high specificity
-
-
?
DNA containing an adenine:7,8-dihydro-8-oxoguanine mispair + H2O
DNA containing an abasic site + adenine
-
primary substrate in vivo
-
-
?
DNA containing an adenine:8-oxoguanine mismatch + H2O
?
-
-
-
?
DNA containing an adenine:guanine mismatch + H2O
adenine + DNA with apurinic site
additional information
?
-
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
highest activity
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
?
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a guanine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a guanine:adenine mismatch + H2O
?
-
-
-
?
DNA containing a guanine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing a guanine:adenine mismatch + H2O
?
-
-
-
?
DNA containing a guanine:adenine mismatch + H2O
?
-
-
-
-
?
DNA containing an adenine:7,8-dihydro-8-oxoadenine mismatch + H2O
adenine + DNA with apurinic site
-
-
-
-
?
DNA containing an adenine:7,8-dihydro-8-oxoadenine mismatch + H2O
adenine + DNA with apurinic site
-
-
-
-
?
DNA containing an adenine:7,8-dihydro-8-oxoadenine mismatch + H2O
adenine + DNA with apurinic site
-
-
-
-
?
DNA containing an adenine:guanine mismatch + H2O
adenine + DNA with apurinic site
-
-
-
-
?
DNA containing an adenine:guanine mismatch + H2O
adenine + DNA with apurinic site
-
-
-
-
?
additional information
?
-
-
the enzyme catalyzes the removal of adenine bases mispaired with 2'-deoxyguanosine and 7,8-dihydro-8-oxo-2'-deoxyguanosine in DNA
-
-
?
additional information
?
-
the enzyme is specific for adenine removal from 7,8-dihydro-8-oxoguanine:adenine as well as guanine:adenine, and cytosine:adenine mispairs in double-stranded DNA
-
-
?
additional information
?
-
-
the enzyme is specific for adenine removal from 7,8-dihydro-8-oxoguanine:adenine as well as guanine:adenine, and cytosine:adenine mispairs in double-stranded DNA
-
-
?
additional information
?
-
no activity with DNA containing a cytosine:8-oxoguanine mismatch
-
-
?
additional information
?
-
-
the enzyme shows no activity with DNA containing a guanine:adenine mismatch
-
-
?
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D179A
-
active site mutant
E78A
-
active site mutant
E78A/D179A
-
active site mutant
C199H
the mutant shows wild type activity
C199S
the mutant shows wild type activity
D138E
the mutant shows wild type activity
E37D
the mutant shows 68% of wild type activity
G253A
-
when 2'-deoxy-2'-fluoroadenosine in duplex paired with guanine or 7,8-dihydro-8-oxo-2'-deoxyguanosine is used, the mutant shows reduced binding affinity. Additionally, compromised glycosylase activity of the mutant enzyme is observed using the nonoptimal guanine:adenine substrate, or at low reaction temperatures
G253D
-
the mutant has a reduced adenine glycosylase activity and affinity for substrate analogues compared to the wild type enzyme
K157A
-
the mutation has no effect on enzyme activities
K158A
-
the mutation has no effect on enzyme activities
K196A
the mutant enzyme exhibits a slight reduction of the rate of adenine removal from a G:A base pair-containing duplex compared to the wild type enzyme
K198A
the mutant enzyme exhibits a significant reduction (15fold) of the rate of adenine removal from a G:A base pair-containing duplex compared to the wild type enzyme
K20A
-
the mutation still catalyzes beta- and delta-elimination reactions and can be trapped as covalent enzyme-DNA intermediates by chemical reduction
Q182L
-
the mutant has significantly lower binding and glycosylase activities for adenine:guanine and adenine:7,8-dihydro-8-oxo-guanine mismatches than the wild type enzyme. The mutant has substantially increased affinity towards thymine:guanine, however, it does not exhibit any thymine/guanine or thymine/7,8-dihydro-8-oxo-guanine glycosylase activity
R194A
the mutant shows wild type activity
S120K
the mutant with bifunctional glycosylase/AP lyase activity is capable of catalyzing DNA strand scission at a rate equivalent to that of adenine excision for both guanine:adenine and 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mispair substrates
S120K/K142A
the mutant with bifunctional glycosylase/AP lyase activity is capable of catalyzing DNA strand scission at a rate equivalent to that of adenine excision for both guanine:adenine and 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mispair substrates
V45A
-
the mutant has significantly lower binding and glycosylase activities for adenine:guanine and adenine:7,8-dihydro-8-oxo-guanine mismatches than the wild type enzyme. The mutant has substantially increased affinity towards thymine:guanine, however, it does not exhibit any thymine/guanine or thymine/7,8-dihydro-8-oxo-guanine glycosylase activity
V45A/Q182L
-
the mutant has similar binding affinities to thymine/guanine as the wild type enzyme
Y82C
-
the mutant has a reduced adenine glycosylase activity and affinity for substrate analogues compared to the wild type enzyme. Additionally, compromised glycosylase activity of the mutant enzyme is observed using the nonoptimal guanine:adenine substrate, or at low reaction temperatures
Y82F
-
when 2-deoxy-2-fluoroadenosine in duplex paired with guanine or 7,8-dihydro-8-oxo-2'-deoxyguanosine is used, the mutant shows reduced binding affinity. Additionally, compromised glycosylase activity of the mutant enzyme is observed using the nonoptimal guanine:adenine substrate, or at low reaction temperatures
Y82L
-
the mutant is unable to discriminate between guanine and 7,8-dihydro-8-oxo-2'-deoxyguanosine when paired with 2'-deoxy-2'-fluoroadenosine
Y126F
the mutant shows a 260fold slower rate of adenine removal compared to the wild type enzyme
G382D
-
the mutant enzyme shows a reduced ability to recognize and repair 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatches
Y165C
-
the mutant enzyme shows a reduced ability to recognize and repair 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatches
D149A
-
active site mutant
E48A
-
active site mutant
E48A/D149A
-
active site mutant
D138C
the mutant shows 47% of wild type activity
D138C
-
the mutation completely inhibits the ability of the enzyme to release guanine from DNA containing a guanine:7,8-dihydro-8-oxo-2'-deoxyguanosine mismatch
D138N
-
inactive
E37C
inactive
E37C
-
the mutation still catalyzes beta- and delta-elimination reactions and can be trapped as covalent enzyme-DNA intermediates by chemical reduction
K142A
the mutant shows slightly reduced activity compared to the wild type enzyme
K142A
-
the enzyme shows a dramatic decrease in the amount of enzyme-DNA cross-links with both 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine (less than 2%) and guanine:adenine (less than 2%) mispairs, despite having the ability to bind DNA and to catalyze apurinic site formation to the same extent as wild type enzyme
K142A
-
the mutant protein is unable to form Schiff base intermediates with DNA substrates. however, the mutant can still bind DNA substrates and has adenine glycosylase activity and promotes a beta/delta-elimination on apurinic DNA
K142A
-
the mutation still catalyzes beta- and delta-elimination reactions and can be trapped as covalent enzyme-DNA intermediates by chemical reduction
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Chepanoske, C.L.; Golinelli, M.P.; Williams, S.D.; David, S.S.
Positively charged residues within the iron-sulfur cluster loop of E. coli MutY participate in damage recognition and removal
Arch. Biochem. Biophys.
380
11-19
2000
Escherichia coli (P17802), Escherichia coli
brenda
Lu, A.L.; Lee, C.Y.; Li, L.; Li, X.
Physical and functional interactions between Escherichia coli MutY and endonuclease VIII
Biochem. J.
393
381-387
2006
Escherichia coli
brenda
Michaels, M.L.; Tchou, J.; Grollman, A.P.; Miller, J.H.
A repair system for 8-oxo-7,8-dihydrodeoxyguanine
Biochemistry
31
10964-10968
1992
Escherichia coli
brenda
Porello, S.L.; Leyes, A.E.; David, S.S.
Single-turnover and pre-steady-state kinetics of the reaction of the adenine glycosylase MutY with mismatch-containing DNA substrates
Biochemistry
37
14756-14764
1998
Escherichia coli
brenda
Porello, S.L.; Cannon, M.J.; David, S.S.
A substrate recognition role for the [4Fe-4S]2+ cluster of the DNA repair glycosylase MutY
Biochemistry
37
6465-6475
1998
Escherichia coli
brenda
Williams, S.D.; David, S.S.
Formation of a Schiff base intermediate is not required for the adenine glycosylase activity of Escherichia coli MutY
Biochemistry
38
15417-15424
1999
Escherichia coli
brenda
Williams, S.D.; David, S.S.
A single engineered point mutation in the adenine glycosylase MutY confers bifunctional glycosylase/AP lyase activity
Biochemistry
39
10098-10109
2000
Escherichia coli (P17802), Escherichia coli
brenda
Messick, T.E.; Chmiel, N.H.; Golinelli, M.P.; Langer, M.R.; Joshua-Tor, L.; David, S.S.
Noncysteinyl coordination to the [4Fe-4S]2+ cluster of the DNA repair adenine glycosylase MutY introduced via site-directed mutagenesis. Structural characterization of an unusual histidinyl-coordinated cluster
Biochemistry
41
3931-3942
2002
Escherichia coli (P17802), Escherichia coli
brenda
Chepanoske, C.L.; Lukianova, O.A.; Lombard, M.; Golinelli-Cohen, M.P.; David, S.S.
A residue in MutY important for catalysis identified by photocross-linking and mass spectrometry
Biochemistry
43
651-662
2004
Escherichia coli
brenda
Livingston, A.L.; Kundu, S.; Henderson Pozzi, M.; Anderson, D.W.; David, S.S.
Insight into the roles of tyrosine 82 and glycine 253 in the Escherichia coli adenine glycosylase MutY
Biochemistry
44
14179-14190
2005
Escherichia coli
brenda
Eberle, R.J.; Coronado, M.A.; Caruso, I.P.; Lopes, D.O.; Miyoshi, A.; Azevedo, V.; Arni, R.K.
Chemical and thermal influence of the [4Fe-4S]2+ cluster of A/G-specific adenine glycosylase from Corynebacterium pseudotuberculosis
Biochim. Biophys. Acta
1850
393-400
2015
Corynebacterium pseudotuberculosis, Corynebacterium pseudotuberculosis ADK29561.1
brenda
Chang, P.; Madabushi, A.; Lu, A.
Insights into the role of Val45 and Gln182 of Escherichia coli MutY in DNA substrate binding and specificity
BMC Biochem.
10
19
2009
Escherichia coli
brenda
Brinkmeyer, M.K.; Pope, M.A.; David, S.S.
Catalytic contributions of key residues in the adenine glycosylase MutY revealed by pH-dependent kinetics and cellular repair assays
Chem. Biol.
19
276-286
2012
Escherichia coli (P17802)
brenda
Eutsey, R.; Wang, G.; Maier, R.J.
Role of a MutY DNA glycosylase in combating oxidative DNA damage in Helicobacter pylori
DNA Repair
6
19-26
2007
Helicobacter pylori
brenda
de Faria, R.C.; Vila-Nova, L.G.; Bitar, M.; Resende, B.C.; Arantes, L.S.; Rebelato, A.B.; Azevedo, V.A.; Franco, G.R.; Machado, C.R.; Santos, L.L.; de Oliveira Lopes, D.
Adenine glycosylase MutY of Corynebacterium pseudotuberculosis presents the antimutator phenotype and evidences of glycosylase/AP lyase activity in vitro
Infect. Genet. Evol.
44
318-329
2016
Corynebacterium pseudotuberculosis
brenda
Manuel, R.C.; Czerwinski, E.W.; Lloyd, R.S.
Identification of the structural and functional domains of MutY, an Escherichia coli DNA mismatch repair enzyme
J. Biol. Chem.
271
16218-16226
1996
Escherichia coli
brenda
Wright, P.M.; Yu, J.; Cillo, J.; Lu, A.L.
The active site of the Escherichia coli MutY DNA adenine glycosylase
J. Biol. Chem.
274
29011-29018
1999
Escherichia coli
brenda
Pope, M.A.; Porello, S.L.; David, S.S.
Escherichia coli apurinic-apyrimidinic endonucleases enhance the turnover of the adenine glycosylase MutY with G A substrates
J. Biol. Chem.
277
22605-22615
2002
Escherichia coli
brenda
Wong, I.; Bernards, A.S.; Miller, J.K.; Wirz, J.A.
A dimeric mechanism for contextual target recognition by MutY glycosylase
J. Biol. Chem.
278
2411-2418
2003
Escherichia coli
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