Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Reference on EC 3.2.2.27 - uracil-DNA glycosylase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Leiros, I.; Moe, E.; Smala, A.O.; McSweeney, S.
Structure of the uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans
Acta Crystallogr. Sect. D
D61
1049-1056
2005
Deinococcus radiodurans (Q9RWH9), Deinococcus radiodurans
Manually annotated by BRENDA team
Kim, G.A.; Sun Lee, M.; Sun, Y.; Loo, B.D.; Lee, J.I.; Lee, J.-H.; Kwon, S.-T.
Characterization of cold-active uracil-DNA glycosylase from Bacillus sp. HJ171 and its use for contamination ontrol in PCR
Appl. Microbiol. Biotechnol.
80
785-794
2008
Bacillus sp. (in: Bacteria) (B6CM51), Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) HJ171 (B6CM51)
Manually annotated by BRENDA team
Dionne, I.; Bell, S.D.
Characterization of an archaeal family 4 uracil DNA glycosylase and its interaction with PCNA and chromatin proteins
Biochem. J.
387
859-863
2005
Saccharolobus solfataricus
Manually annotated by BRENDA team
Masaoka,A.; Matsubara, M.; Hasegawa, R.; Tanaka,T.; Kurisu,S.; Terato,H.; Ohyama,Y.; Karino, N.; Matsuda,A
Ide, H.: Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions
Biochemistry
42
5003-5012
2003
Homo sapiens (Q53HV7), Homo sapiens, Rattus norvegicus (Q811Q1)
Manually annotated by BRENDA team
Duraffour, S.; Ishchenko, A.A
Saparbaev, M.; Crance, J.-M.; Garin, D.: Substrate specificity of homogeneous Monkeypox virus uracil-DNA glycosylase
Biochemistry
46
11874-11881
2007
Monkeypox virus (Q8V4Y4), Monkeypox virus, Monkeypox virus Zaire 1996 (Q8V4Y4)
Manually annotated by BRENDA team
Lee, M.S.; Kim, G.A.; Seo, M.S.; Lee, J.-H.; Kwon, S.-T.
Characterization of heat-labile uracil-DNA glycosylase from Psychrobacter sp. HJ147 and its application to the polymerase chain reaction
Biotechnol. Appl. Biochem.
52
167-175
2009
Psychrobacter sp. (D3G6S3), Psychrobacter sp. HJ147 (D3G6S3)
Manually annotated by BRENDA team
Schormann, N.; Grigorian, A.; Samal, A; Krishnan, R.; DeLucas, L.; Chattopadhyay, D.
Crystal structure of vaccinia virus uracil-DNA glycosylase reveals dimeric assembly
BMC Struct. Biol.
7
45
2007
Vaccinia virus
Manually annotated by BRENDA team
Guo, C.; Zhang, X.; Fink, S.P.; Platzer, P.; Wilson, K.; Willson, J.K.; Wang, Z.; Markowitz, S.D.
Ugene, a newly identified protein that is commonly overexpressed in cancer, and that binds uracil DNA-glycosylase
Cancer Res.
68
6118-6126
2008
Homo sapiens (P22674)
Manually annotated by BRENDA team
Lanes, O.; Guddal, P.H.; Gjellesvik, D.R.; Willassen, N.P.
Purification and characterization of a cold-adapted uracil-DNA glycosylase from atlantic cod (Gadus morhua)
Comp. Biochem. Physiol. B
127
399-410
2000
Gadus morhua
Manually annotated by BRENDA team
Haushalter, K.A
Stukenberg, P.T.; Kirschner, M.W.; Verdine, G.L.: Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors
Curr. Biol.
9
174-185
1999
Xenopus laevis, Homo sapiens (Q53HV7), Homo sapiens
Manually annotated by BRENDA team
Sandigursky, M.; Franklin, W.A.
Thermostable uracil-DNA glycosylase from Thermotoga maritima, a member of a novel class of DNA repair enzymes
Curr. Biol.
9
531-534
1999
Thermotoga maritima, Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
Manually annotated by BRENDA team
Chen, C.-Y.; Mosbaugh, D.W.; Bennett, S.E.
Mutations at arginine 276 transform human uracil-DNAglycosylase into a single-stranded DNA-specific uracil-DNA glycosylase
DNA Repair
4
793-805
2005
Homo sapiens (P13051), Homo sapiens
Manually annotated by BRENDA team
Sartori, A.A.; Fitz-Gibbon, S.; Yang, H.; Miller, J.H.; Jiricny, J.
A novel uracil-DNA glycosylase with broad substrate specificity and an unusual active site
EMBO J.
21
3182-3191
2002
Pyrobaculum aerophilum (Q8ZXE0), Pyrobaculum aerophilum (Q8ZYS2), Pyrobaculum aerophilum
Manually annotated by BRENDA team
Purnapatre, K.; Varshney, U.
Uracil DNA glycosylase from Mycobacterium smegmatis and its distinct biochemical properties
Eur. J. Biochem.
256
580-588
1998
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis SN2
Manually annotated by BRENDA team
Sobek, H.; Schmidt, M.; Frey, B.; Kaluza, K.
Heat-labile uracil-DNA glycosylase: purification and characterization
FEBS Lett.
388
1-4
1996
Escherichia coli
Manually annotated by BRENDA team
Sandigursky, M.; Franklin, W.A.
Uracil-DNA glycosylase in the extreme thermophile Archaeoglobus fulgidus
J. Biol. Chem.
275
19146-19149
2000
Archaeoglobus fulgidus, Archaeoglobus fulgidus (O28007)
Manually annotated by BRENDA team
Boorstein, R.J.; Cumming, A.; Marenstein, D.R.; Chan, M.K.; Ma, Y.; Neubert, T.A.; Brown, S.M.; Teebor, G.W.
Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1
J. Biol. Chem.
276
41991-41997
2001
Homo sapiens (Q53HV7), Homo sapiens, Bos taurus (Q59T47), Bos taurus
Manually annotated by BRENDA team
Kavli, B.; Sundheim, O.; Akbari, M.; Otterlei, M.; Nilsen, H.; Skorpen, F.; Aas, P.A.; Hagen, L.; Krokan, H.E.; Slupphaug, G.
hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup
J. Biol. Chem.
277
39926-39936
2002
Homo sapiens, Homo sapiens (P22674)
Manually annotated by BRENDA team
Moe, E.; Leiros, I.; Smalas, A.O.; McSweeney, S.
The crystal structure of mismatch-specific uracil-DNA glycosylase (MUG) from Deinococcus radiodurans reveals a novel catalytic residue and broad substrate specificity
J. Biol. Chem.
281
569-577
2006
Deinococcus radiodurans (Q9RWH9), Deinococcus radiodurans
Manually annotated by BRENDA team
Darwanto, A.; Theruvathu, J.A.; Sowers, J.L.; Rogstad, D.K.; Pascal, T.; Goddard III, W.; Sowers, L.C.
Mechanisms of base selection by human single-stranded selective monofunctional uracil-DNA glycosylase
J. Biol. Chem.
284
15835-15846
2009
Homo sapiens (Q53HV7), Homo sapiens
Manually annotated by BRENDA team
Hoseki, J.; Okamoto, A.; Masui, R.; Shibata, T.; Inoue, Y.; Yokoyama, S.; Kuramitsu, S.
Crystal structure of a family 4 uracil-DNA glycosylase from Thermus thermophilus HB8
J. Mol. Biol.
333
515-526
2003
Thermus thermophilus (Q7WYV4), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q7WYV4)
Manually annotated by BRENDA team
Kosaka, H.; Hoseki, J.; Nakagawa, N.; Kuramitsu, S.; Masui, R.
Crystal structure of family 5 uracil-DNA glycosylase bound to DNA
J. Mol. Biol.
373
839-850
2007
Thermus thermophilus (Q5SJG5), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SJG5)
Manually annotated by BRENDA team
Mi, R.; Dong, L.; Kaulgud, T.; Hackett, K.W.; Dominy, B.N.; Cao, W.
Insights from xanthine and uracil DNA glycosylase activities of bacterial and human SMUG1: switching SMUG1 to UDG
J. Mol. Biol.
385
761-778
2009
Geobacter metallireducens (Q39ZI0), Geobacter metallireducens, Homo sapiens (Q53HV7), Homo sapiens, Geobacter metallireducens GS-15 / ATCC 53774 / DSM 7210 (Q39ZI0)
Manually annotated by BRENDA team
Im, E.K.; Han, Y.S.; Chung, J.H.
Functional changes in a novel uracil-DNA glycosylase determined by mutational analyses
Mikrobiologiia
77
644-650
2008
Methanocaldococcus jannaschii, Methanocaldococcus jannaschii (Q58829), Methanocaldococcus jannaschii DSM 2661 (Q58829)
Manually annotated by BRENDA team
Priet, S.; Gros, N.; Navarro, J.-M.; Boretto, J.I.; Canard, B.; Querat, G.; Sire, J.
HIV-1-associated uracil DNA glycosylase activity controls dUTP misincorporation in viral DNA and is essential to the HIV-1 life cycle
Mol. Cell
17
479-490
2005
Homo sapiens (P22674)
Manually annotated by BRENDA team
Wibley J.E.; Waters T.R.; Haushalter K.; Verdine G.L.; Pearl L.H.
Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1
Mol. Cell
11
1647-59
2003
Mus musculus (Q6P5C5)
Manually annotated by BRENDA team
Pearl, J.H.
Structure and function in the uracil-DNA glycosylase superfamily
Mutat. Res.
460
165-181
2000
Escherichia coli, Homo sapiens, Human alphaherpesvirus 1 (P10186)
Manually annotated by BRENDA team
Nakamura, N.; Morinaga, H.; Kikuchi, M.; Yonekura, S.-I.; Ishii1, N.; Yamamoto, K.; Yonei S.; Zhang, Q.-M.
Cloning and characterization of uracil-DNA glycosylase and the biological consequences of the loss of its function in the nematode Caenorhabditis elegans
Mutagenesis
23
407-413
2008
Caenorhabditis elegans, Caenorhabditis elegans Bristol N2
Manually annotated by BRENDA team
Parikh, S.S.; Putnam, C.D.; Tainer, J.A.
Lessons learned from structural results on uracil-DNA glycosylase
Mutat. Res.
460
183-199
2000
Homo sapiens
Manually annotated by BRENDA team
Sandigursky, M.; Faje, A.; Franklin, W.A.
Characterization of the full length uracil-DNA glycosylase in the extreme thermophile Thermotoga maritima
Mutat. Res.
485
187-195
2001
Thermotoga maritima
Manually annotated by BRENDA team
Bellamy, S.R.; Baldwin, G.S.
A kinetic analysis of substrate recognition by uracil-DNA glycosylase from Herpes simplex virus type I
Nucleic Acids Res.
29
3857-3863
2001
Human alphaherpesvirus 1, Human alphaherpesvirus 1 HSV-1
Manually annotated by BRENDA team
Hardeland, U.; Bentele, M.; Jiricny, J.; Schaer, P.
The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs
Nucleic Acids Res.
31
2261-2271
2003
Schizosaccharomyces pombe (O59825), Schizosaccharomyces pombe, Drosophila melanogaster (Q9V4D8), Drosophila melanogaster
Manually annotated by BRENDA team
Scaramozzino, N.; Sanz, G.; Crance, J.M.; Saparbae, M.; Drillien, R.; Laval, J.; Kavli, B.; Garin, D.
Characterisation of the substrate specificity of homogeneous vaccinia virus uracil-DNA glycosylase
Nucleic Acids Res.
31
4950-4957
2003
Vaccinia virus
Manually annotated by BRENDA team
Matsubara, M.; Tanaka, T.; Terato, H.; Ohmae, E.; Izumi, S.; Katayanagi, K.; Ide, H.
Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase
Nucleic Acids Res.
32
5291-5302
2004
Homo sapiens (Q53HV7), Homo sapiens
Manually annotated by BRENDA team
Porecha, R.H.; Stivers, J.T.
Uracil DNA glycosylase uses DNA hopping and short-range sliding to trap extrahelical uracils
Proc. Natl. Acad. Sci. USA
105
10791-10796
2008
Escherichia coli
Manually annotated by BRENDA team
Liu, X.; Liu, J.
Cloning, expression, and characterization of uracil-DNA glycosylase of Chlamydia pneumoniae in Escherichia coli
Protein Expr. Purif.
35
46-53
2004
Chlamydia pneumoniae (Q9Z7D3), Chlamydia pneumoniae, Chlamydia pneumoniae AR39 (Q9Z7D3), Chlamydia pneumoniae AR39
Manually annotated by BRENDA team
Xiao, G.; Tordova, M.; Jagadeesh, J.; Drohat, A.C.; Stivers, J.T.; Gilliland, G.L.
Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited
Proteins
35
13-24
1999
Escherichia coli, Escherichia coli B / ATCC 11303
Manually annotated by BRENDA team
Raeder, I.L.; Moe, E.; Willassen, N.P.; Smalas, A.O.; Leiros, I.
Structure of uracil-DNA N-glycosylase (UNG) from Vibrio cholerae: mapping temperature adaptation through structural and mutational analysis
Acta Crystallogr. Sect. F
66
130-136
2010
Aliivibrio salmonicida, Vibrio cholerae (Q9KPK8), Vibrio cholerae
Manually annotated by BRENDA team
Aziz, M.A.; Schupp, J.E.; Kinsella, T.J.
Modulation of the activity of methyl binding domain protein 4 (MBD4/MED1) while processing iododeoxyuridine generated DNA mispairs
Cancer Biol. Ther.
8
1156-1163
2009
Homo sapiens
Manually annotated by BRENDA team
Ma, K.W.; Au, S.W.; Waye, M.M.
Over-expression of SUMO-1 induces the up-regulation of heterogeneous nuclear ribonucleoprotein A2/B1 isoform B1 (hnRNP A2/B1 isoform B1) and uracil DNA glycosylase (UDG) in HepG2 cells
Cell Biochem. Funct.
27
228-237
2009
Homo sapiens
Manually annotated by BRENDA team
Guo, Y.; Bandaru, V.; Jaruga, P.; Zhao, X.; Burrows, C.J.; Iwai, S.; Dizdaroglu, M.; Bond, J.P.; Wallace, S.S.
The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate preferences from their Escherichia coli counterparts
DNA Repair
9
177-190
2010
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Schomacher, L.; Schuerer, K.A.; Ciirdaeva, E.; McDermott, P.; Chong, J.P.; Kramer, W.; Fritz, H.J.
Archaeal DNA uracil repair via direct strand incision: A minimal system reconstituted from purified components
DNA Repair
9
438-447
2010
Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus DELTAH
Manually annotated by BRENDA team
Skjeldam, H.K.; Kassahun, H.; Fensgard, O.; Sengupta, T.; Babaie, E.; Lindvall, J.M.; Arczewska, K.; Nilsen, H.
Loss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents
DNA Repair
9
861-870
2010
Caenorhabditis elegans
Manually annotated by BRENDA team
Kim, G.; Sun, Y.; Song, J.; Bae, H.; Kim, J.; Kwon, S.
Properties of cold-active uracil-DNA glycosylase from Photobacterium aplysiae GMD509, and its PCR application for carryover contamination control
Enzyme Microb. Technol.
44
263-268
2009
Photobacterium aplysiae (C1INF0), Photobacterium aplysiae GMD509 (C1INF0)
-
Manually annotated by BRENDA team
Knaevelsrud, I.; Slupphaug, G.; Leiros, I.; Matsuda, A.; Ruoff, P.; Bjelland, S.
Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1
Int. J. Radiat. Biol.
85
413-420
2009
Homo sapiens
Manually annotated by BRENDA team
Huang, H.; Stivers, J.T.; Greenberg, M.M.
Competitive inhibition of uracil DNA glycosylase by a modified nucleotide whose triphosphate is a substrate for DNA polymerase
J. Am. Chem. Soc.
131
1344-1345
2009
Escherichia coli, Homo sapiens (P13051)
Manually annotated by BRENDA team
Wanner, R.M.; Castor, D.; Guethlein, C.; Boettger, E.C.; Springer, B.; Jiricny, J.
The uracil DNA glycosylase UdgB of Mycobacterium smegmatis protects the organism from the mutagenic effects of cytosine and adenine deamination
J. Bacteriol.
191
6312-6319
2009
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Bogani, F.; Chua, C.N.; Boehmer, P.E.
Reconstitution of uracil DNA glycosylase-initiated base excision repair in Herpes simplex virus-1
J. Biol. Chem.
284
16784-16790
2009
Human alphaherpesvirus 1, Human alphaherpesvirus 1 HSV-1
Manually annotated by BRENDA team
Jones, K.L.; Roche, M.; Gantier, M.P.; Begum, N.A.; Honjo, T.; Caradonna, S.; Williams, B.R.; Mak, J.
X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells
J. Biol. Chem.
285
18603-18614
2010
Homo sapiens
Manually annotated by BRENDA team
Bogani, F.; Corredeira, I.; Fernandez, V.; Sattler, U.; Rutvisuttinunt, W.; Defais, M.; Boehmer, P.E.
Association between the herpes simplex virus-1 DNA polymerase and uracil DNA glycosylase
J. Biol. Chem.
285
27664-27672
2010
Human alphaherpesvirus 1
Manually annotated by BRENDA team
Cole, H.A.; Tabor-Godwin, J.M.; Hayes, J.J.
Uracil DNA glycosylase activity on nucleosomal DNA depends on rotational orientation of targets
J. Biol. Chem.
285
2876-2885
2010
Escherichia coli (P12295)
Manually annotated by BRENDA team
Cordoba-Canero, D.; Dubois, E.; Ariza, R.R.; Doutriaux, M.P.; Roldan-Arjona, T.
Arabidopsis uracil DNA glycosylase (UNG) is required for base excision repair of uracil and increases plant sensitivity to 5-fluorouracil
J. Biol. Chem.
285
7475-7483
2010
Arabidopsis thaliana
Manually annotated by BRENDA team
Strang, B.L.; Coen, D.M.
Interaction of the human cytomegalovirus uracil DNA glycosylase UL114 with the viral DNA polymerase catalytic subunit UL54
J. Gen. Virol.
91
2029-2033
2010
Human betaherpesvirus 5
Manually annotated by BRENDA team
Zharkov, D.O.; Mechetin, G.V.; Nevinsky, G.A.
Uracil-DNA glycosylase: Structural, thermodynamic and kinetic aspects of lesion search and recognition
Mutat. Res.
685
11-20
2010
Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Boesch, P.; Ibrahim, N.; Paulus, F.; Cosset, A.; Tarasenko, V.; Dietrich, A.
Plant mitochondria possess a short-patch base excision DNA repair pathway
Nucleic Acids Res.
37
5690-5700
2009
Arabidopsis thaliana (Q9LIH6), Arabidopsis thaliana
Manually annotated by BRENDA team
Fenard, D.; Houzet, L.; Bernard, E.; Tupin, A.; Brun, S.; Mougel, M.; Devaux, C.; Chazal, N.; Briant, L.
Uracil DNA glycosylase 2 negatively regulates HIV-1 LTR transcription
Nucleic Acids Res.
37
6008-6018
2009
Homo sapiens
Manually annotated by BRENDA team
Bharti, S.K.; Varshney, U.
Analysis of the impact of a uracil DNA glycosylase attenuated in AP-DNA binding in maintenance of the genomic integrity in Escherichia coli
Nucleic Acids Res.
38
2291-2301
2010
Escherichia coli (P12295)
Manually annotated by BRENDA team
Visnes, T.; Doseth, B.; Pettersen, H.; Hagen, L.; Sousa, M.; Akbari, M.; Otterlei, M.; Kavli, B.; Slupphaug, G.; Krokan, H.
Uracil in DNA and its processing by different DNA glycosylases
Philos. Trans. R. Soc. Lond. B Biol. Sci.
364
563-568
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Begum, N.A.; Stanlie, A.; Doi, T.; Sasaki, Y.; Jin, H.W.; Kim, Y.S.; Nagaoka, H.; Honjo, T.
Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination
Proc. Natl. Acad. Sci. USA
106
2752-2757
2009
Mus musculus
Manually annotated by BRENDA team
Ward, T.M.; Williams, M.V.; Traina-Dorge, V.; Gray, W.L.
The Simian varicella virus uracil DNA glycosylase and dUTPase genes are expressed in vivo, but are non-essential for replication in cell culture
Virus Res.
142
78-84
2009
Cercopithecine alphaherpesvirus 9, Cercopithecine alphaherpesvirus 9 SVV
Manually annotated by BRENDA team
Engstrom, L.; Partington, O.; David, S.
An iron-sulfur cluster loop motif in the Archaeoglobus fulgidus uracil-DNA glycosylase mediates efficient uracil recognition and removal
Biochemistry
51
5187-5197
2012
Archaeoglobus fulgidus
Manually annotated by BRENDA team
Knavelsrud, I.; Moen, M.; Grosvik, K.; Haugland, G.; Birkeland, N.; Klungland, A.; Leiros, I.; Bjelland, S.
The hyperthermophilic euryarchaeon Archaeoglobus fulgidus repairs uracil by single-nucleotide replacement
J. Bacteriol.
192
5755-5766
2010
Archaeoglobus fulgidus (O28007), Archaeoglobus fulgidus
Manually annotated by BRENDA team
Moen, M.N.; Knaevelsrud, I.; Haugland, G.T.; Grosvik, K.; Birkeland, N.K.; Klungland, A.; Bjelland, S.
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair
J. Bacteriol.
193
4495-4508
2011
Thermoplasma acidophilum (Q9HKW6), Thermoplasma acidophilum
Manually annotated by BRENDA team
Sartori, A.A.; Schr, P.; Fitz-Gibbon, S.; Miller, J.H.; Jiricny, J.
Biochemical characterization of uracil processing activities in the hyperthermophilic archaeon Pyrobaculum aerophilum
J. Biol. Chem.
276
29979-29986
2001
Pyrobaculum aerophilum (Q8ZYS2), Pyrobaculum aerophilum, Pyrobaculum aerophilum DSM 7523 (Q8ZYS2)
Manually annotated by BRENDA team
Kiyonari, S.; Uchimura, M.; Shirai, T.; Ishino, Y.
Physical and functional interactions between uracil-DNA glycosylase and proliferating cell nuclear antigen from the euryarchaeon Pyrococcus furiosus
J. Biol. Chem.
283
24185-24193
2008
Pyrococcus furiosus (Q8U144), Pyrococcus furiosus
Manually annotated by BRENDA team
Knaevelsrud, I.; Ruoff, P.; Anensen, H.; Klungland, A.; Bjelland, S.; Birkeland, N.K.
Excision of uracil from DNA by the hyperthermophilic Afung protein is dependent on the opposite base and stimulated by heat-induced transition to a more open structure
Mutat. Res.
487
173-190
2001
Archaeoglobus fulgidus (O28007), Archaeoglobus fulgidus
Manually annotated by BRENDA team
Chung, J.H.; Im, E.K.; Park, H.Y.; Kwon, J.H.; Lee, S.; Oh, J.; Hwang, K.C.; Lee, J.H.; Jang, Y.
A novel uracil-DNA glycosylase family related to the helix-hairpin-helix DNA glycosylase superfamily
Nucleic Acids Res.
31
2045-2055
2003
Methanocaldococcus jannaschii (Q58829), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q58829)
Manually annotated by BRENDA team
Kawai, A.; Higuchi, S.; Tsunoda, M.; Nakamura, K.T.; Miyamoto, S.
Purification, crystallization and preliminary X-ray analysis of uracil-DNA glycosylase from Sulfolobus tokodaii strain 7
Acta Crystallogr. Sect. F
68
1102-1105
2012
Sulfurisphaera tokodaii (Q96YD0), Sulfurisphaera tokodaii 7 (Q96YD0)
Manually annotated by BRENDA team
Koulis, A.; Cowan, D.A.; Pearl, L.H.; Savva, R.
Uracil-DNA glycosylase activities in hyperthermophilic micro-organisms
FEMS Microbiol. Lett.
143
267-271
1996
Pyrobaculum islandicum, Pyrococcus furiosus, Saccharolobus shibatae, Saccharolobus solfataricus, Thermotoga maritima
Manually annotated by BRENDA team
Knvelsrud, I.; Kazazic, S.; Birkeland, N.K.; Bjelland, S.
The pH optimum of native uracil-DNA glycosylase of Archaeoglobus fulgidus compared to recombinant enzyme indicates adaption to cytosolic pH
Acta Biochim. Pol.
61
393-395
2014
Archaeoglobus fulgidus
Manually annotated by BRENDA team
Assefa, N.G.; Niiranen, L.; Johnson, K.A.; Leiros, H.K.; Smalas, A.O.; Willassen, N.P.; Moe, E.
Structural and biophysical analysis of interactions between cod and human uracil-DNA N-glycosylase (UNG) and UNG inhibitor (Ugi)
Acta Crystallogr. Sect. D
70
2093-2100
2014
Homo sapiens (P13051), Homo sapiens, Gadus morhua (Q9I983), Gadus morhua
Manually annotated by BRENDA team
Sartmatova, D.; Nash, T.; Schormann, N.; Nuth, M.; Ricciardi, R.; Banerjee, S.; Chattopadhyay, D.
Crystallization and preliminary X-ray diffraction analysis of three recombinant mutants of Vaccinia virus uracil DNA glycosylase
Acta Crystallogr. Sect. F
69
295-301
2013
Vaccinia virus (Q91UM2), Vaccinia virus Ankara (Q91UM2)
Manually annotated by BRENDA team
Xiang, Y.; Lu, Y.
Expanding targets of DNAzyme-based sensors through deactivation and activation of DNAzymes by single uracil removal: sensitive fluorescent assay of uracil-DNA glycosylase
Anal. Chem.
84
9981-9987
2012
Escherichia coli
Manually annotated by BRENDA team
Schonhoft, J.D.; Kosowicz, J.G.; Stivers, J.T.
DNA translocation by human uracil DNA glycosylase: role of DNA phosphate charge
Biochemistry
52
2526-2535
2013
Homo sapiens
Manually annotated by BRENDA team
Tao, J.; Song, P.; Sato, Y.; Nishizawa, S.; Teramae, N.; Tong, A.; Xiang, Y.
A label-free and sensitive fluorescent method for the detection of uracil-DNA glycosylase activity
Chem. Commun. (Camb. )
51
929-932
2015
Homo sapiens
Manually annotated by BRENDA team
Assefa, N.; Niiranen, L.; Willassen, N.; Smals, A.; Moe, E.
Thermal unfolding studies of cold adapted uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua). A comparative study with human UNG
Comp. Biochem. Physiol. B
161
60-68
2012
Gadus morhua, Homo sapiens (P13051), Homo sapiens
Manually annotated by BRENDA team
Hegre, S.A.; Saetrom, P.; Aas, P.A.; Pettersen, H.S.; Otterlei, M.; Krokan, H.E.
Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase
DNA Repair
12
80-86
2013
Homo sapiens
Manually annotated by BRENDA team
Yousif, A.S.; Stanlie, A.; Begum, N.A.; Honjo, T.
Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination
Int. Immunol.
26
575-578
2014
Mus musculus
Manually annotated by BRENDA team
Wu, D.; Chen, L.; Sun, Q.; Wu, X.; Jia, S.; Meng, A.
Uracil-DNA glycosylase is involved in DNA demethylation and required for embryonic development in the zebrafish embryo
J. Biol. Chem.
289
15463-15473
2014
Danio rerio
Manually annotated by BRENDA team
Franco, D.; Sgrignani, J.; Bussi, G.; Magistrato, A.
Structural role of uracil DNA glycosylase for the recognition of uracil in DNA duplexes. Clues from atomistic simulations
J. Chem. Inf. Model.
53
1371-1387
2013
Homo sapiens (P13051)
Manually annotated by BRENDA team
Lee, D.H.; Liu, Y.; Lee, H.W.; Xia, B.; Brice, A.R.; Park, S.H.; Balduf, H.; Dominy, B.N.; Cao, W.
A structural determinant in the uracil DNA glycosylase superfamily for the removal of uracil from adenine/uracil base pairs
Nucleic Acids Res.
2
1081-1089
2015
Escherichia coli (P12295), Escherichia coli
Manually annotated by BRENDA team
Kimber, S.T.; Brown, T.; Fox, K.R.
A mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosine
PLoS ONE
9
e95394
2014
Escherichia coli (P12295)
Manually annotated by BRENDA team
Kitamura, K.; Wang, Z.; Chowdhury, S.; Simadu, M.; Koura, M.; Muramatsu, M.
Uracil DNA glycosylase counteracts APOBEC3G-induced hypermutation of hepatitis B viral genomes: excision repair of covalently closed circular DNA
PLoS Pathog.
9
e1003361
2013
Homo sapiens
Manually annotated by BRENDA team
Weil, A.F.; Ghosh, D.; Zhou, Y.; Seiple, L.; McMahon, M.A.; Spivak, A.M.; Siliciano, R.F.; Stivers, J.T.
Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration
Proc. Natl. Acad. Sci. USA
110
E448-E457
2013
Homo sapiens
Manually annotated by BRENDA team
Yousif, A.S.; Stanlie, A.; Mondal, S.; Honjo, T.; Begum, N.A.
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
Proc. Natl. Acad. Sci. USA
111
E1016-E1024
2014
Mus musculus
Manually annotated by BRENDA team
Sandigursky, M.; Franklin, W.
Thermostable uracil-DNA glycosylase from Thermotoga maritima, a member of a novel class of DNA repair enzymes
Curr. Biol.
9
531-534
1999
Thermotoga maritima (Q9WYY1), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9WYY1)
Manually annotated by BRENDA team
Arif, S.M.; Geethanandan, K.; Mishra, P.; Surolia, A.; Varshney, U.; Vijayan, M.
Structural plasticity in Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) and its functional implications
Acta Crystallogr. Sect. D
71
1514-1527
2015
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Pedersen, H.L.; Johnson, K.A.; McVey, C.E.; Leiros, I.; Moe, E.
Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA
Acta Crystallogr. Sect. D
71
2137-2149
2015
Deinococcus radiodurans (Q9RWH9), Deinococcus radiodurans, Deinococcus radiodurans ATCC 13939 (Q9RWH9)
Manually annotated by BRENDA team
Wu, Y.; Wang, L.; Zhu, J.; Jiang, W.
A DNA machine-based fluorescence amplification strategy for sensitive detection of uracil-DNA glycosylase activity
Biosens. Bioelectron.
68
654-659
2015
Homo sapiens
Manually annotated by BRENDA team
Ahn, J.K.; Lee, C.Y.; Park, K.S.; Park, H.G.
Abasic site-assisted inhibition of nicking endonuclease activity for the sensitive determination of uracil DNA glycosylase
Biotechnol. J.
13
e1700603
2018
Homo sapiens
Manually annotated by BRENDA team
Schormann, N.; Banerjee, S.; Ricciardi, R.; Chattopadhyay, D.
Binding of undamaged double stranded DNA to vaccinia virus uracil-DNA glycosylase
BMC Struct. Biol.
15
10
2015
Vaccinia virus (P04303), Vaccinia virus
Manually annotated by BRENDA team
Tao, J.; Song, P.; Sato, Y.; Nishizawa, S.; Teramae, N.; Tong, A.; Xiang, Y.
A label-free and sensitive fluorescent method for the detection of uracil-DNA glycosylase activity
Chem. Commun. (Camb.)
51
929-932
2015
Escherichia coli
Manually annotated by BRENDA team
Assefa, N. G.; Niiranen, L.; Willassen, N. P.; Smalas, A.; Moe, E.
Thermal unfolding studies of cold adapted uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua). A comparative study with human UNG
Comp. Biochem. Physiol. B
161
60-68
2012
Gadus morhua, Homo sapiens (P13051), Homo sapiens
Manually annotated by BRENDA team
Li, J.; Yang, Y.; Guevara, J.; Wang, L.; Cao, W.
Identification of a prototypical single-stranded uracil DNA glycosylase from Listeria innocua
DNA Repair
57
107-115
2017
Listeria innocua (Q926U4), Listeria innocua
Manually annotated by BRENDA team
Kawai, A.; Higuchi, S.; Tsunoda, M.; Nakamura, K.T.; Yamagata, Y.; Miyamoto, S.
Crystal structure of family 4 uracil-DNA glycosylase from Sulfolobus tokodaii and a function of tyrosine 170 in DNA binding
FEBS Lett.
589
2675-2682
2015
Sulfurisphaera tokodaii (Q96YD0), Sulfurisphaera tokodaii
Manually annotated by BRENDA team
Yi, G.S.; Wang, W.W.; Cao, W.G.; Wang, F.P.; Liu, X.P.
Sulfolobus acidocaldarius UDG can remove dU from the RNA backbone insight into the specific recognition of uracil linked with deoxyribose
Genes (Basel)
8
E38
2017
Sulfolobus acidocaldarius, Sulfolobus acidocaldarius DSM639
Manually annotated by BRENDA team
Burmeister, W.P.; Tarbouriech, N.; Fender, P.; Contesto-Richefeu, C.; Peyrefitte, C.N.; Iseni, F.
Crystal structure of the vaccinia virus uracil-DNA glycosylase in complex with DNA
J. Biol. Chem.
290
17923-17934
2015
Vaccinia virus
Manually annotated by BRENDA team
Esadze, A.; Rodriguez, G.; Weiser, B.P.; Cole, P.A.; Stivers, J.T.
Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cells
Nucleic Acids Res.
45
12413-12424
2017
Homo sapiens
Manually annotated by BRENDA team
Chembazhi, U.V.; Patil, V.V.; Sah, S.; Reeve, W.; Tiwari, R.P.; Woo, E.; Varshney, U.
Uracil DNA glycosylase (UDG) activities in Bradyrhizobium diazoefficiens characterization of a new class of UDG with broad substrate specificity
Nucleic Acids Res.
45
5863-5876
2017
Bradyrhizobium diazoefficiens (Q89XR0), Bradyrhizobium diazoefficiens, Bradyrhizobium diazoefficiens USDA110 (Q89XR0)
Manually annotated by BRENDA team
Sarno, A.; Lundbaek, M.; Liabakk, N.B.; Aas, P.A.; Mjelle, R.; Hagen, L.; Sousa, M.M.L.; Krokan, H.E.; Kavli, B.
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil
Nucleic Acids Res.
47
4569-4585
2019
Homo sapiens (P13051), Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Zhang, Y.; Mao, J.; Huang, J.; Meng, P.; Gao, F.
A uracil-DNA glycosylase functions in spore development and pathogenicity of Verticillium dahliae
Physiol. Mol. Plant Pathol.
92
148-153
2015
Verticillium dahliae
-
Manually annotated by BRENDA team
Herate, C.; Vigne, C.; Guenzel, C.A.; Lambele, M.; Rouyez, M.C.; Benichou, S.
Uracil DNA glycosylase interacts with the p32 subunit of the replication protein A complex to modulate HIV-1 reverse transcription for optimal virus dissemination
Retrovirology
13
26
2016
Homo sapiens
Manually annotated by BRENDA team
Xia, B.; Liu, Y.; Guevara, J.; Li, J.; Jilich, C.; Yang, Y.; Wang, L.; Dominy, B.N.; Cao, W.
Correlated mutation in the evolution of catalysis in uracil DNA glycosylase superfamily
Sci. Rep.
7
45978
2017
Thermus thermophilus (Q5SKC5), Thermus thermophilus
Manually annotated by BRENDA team
Shiraishi, M.; Ishino, S.; Heffernan, M.; Cann, I.; Ishino, Y.
The mesophilic archaeon Methanosarcina acetivorans counteracts uracil in DNA with multiple enzymes EndoQ, ExoIII, and UDG
Sci. Rep.
8
15791
2018
Methanosarcina acetivorans (Q8TNM0), Methanosarcina acetivorans ATCC 35395 (Q8TNM0)
Manually annotated by BRENDA team
Ren, R.; Shi, K.; Yang, J.; Yuan, R.; Xiang, Y.
DNA three way junction-mediated recycling amplification for sensitive electrochemical monitoring of uracil-DNA glycosylase activity and inhibition
Sens. Actuators B Chem.
258
783-788
2018
Homo sapiens
-
Manually annotated by BRENDA team
Wang, L.; Zhang, H.; Xie, Y.; Chen, H.; Ren, C.; Chen, X.
Target-mediated hyperbranched amplification for sensitive detection of human alkyladenine DNA glycosylase from HeLa cells
Talanta
194
846-851
2019
Homo sapiens (P13051)
Manually annotated by BRENDA team