Reference on EC 3.2.2.22 - rRNA N-glycosylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Xu, Y.Z.; Liu, W.Y.
Effects of the active aldehyde group generated by RNA N-glycosidase in the sarcin/ricin domain of rat 28S ribosomal RNA on peptide elongation
Biol. Chem.
381
113-119
2000
Ricinus communis, Cinnamomum camphora, Saponaria ocymoides, Trichosanthes sp., Gypsophila vaccaria
Endo, Y.; Tsurugi, K.
The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA
J. Biol. Chem.
263
8735-8739
1988
Ricinus communis
Endo, Y.; Tsurugi, K.
The RNA N-glycosidase activity of ricin A-chain
Nucleic Acids Symp. Ser.
19
139-142
1988
Ricinus communis
Endo, Y.; Tsurugi, K.; Lambert, J.M.
The site of action of six different ribosome-inactivating proteins from plants on eukaryotic ribosomes: the RNA N-glycosidase activity of the proteins
Biochem. Biophys. Res. Commun.
150
1032-1036
1988
Suregada multiflora, Momordica charantia, Phytolacca americana, Saponaria officinalis
Bolognesi, A.; Barbieri, L.; Carnicelli, D.; Abbondanza, A.; Cenini, P.; Falasca, A.I.; Dinota, A.; Stirpe, F.
Purification and properties of a new ribosome-inactivating protein with RNA N-glycosidase activity suitable for immunotoxin preparation from the seeds of Momordica cochinchinensis
Biochim. Biophys. Acta
993
287-292
1989
Momordica cochinchinensis
Habuka, N.; Miyano, M.; Kataoka, J.; Tsuge, H.; Noma, M.
Specificities of RNA N-glycosidase activity of Mirabilis antiviral protein variants
J. Biol. Chem.
267
7758-7760
1992
Mirabilis jalapa
Ferreras, J.M.; Barbieri, L.; Girbes, T.; Battelli, M.G.; Rojo, M.A.; Arias, F.J.; Rocher, M.A.; Soriano, F.; Mendez, E.; Stirpe, F.
Distribution and properties of major ribosome-inactivating proteins (28 S rRNA N-glycosidases) of the plant Saponaria officinalis L. (Caryophyllaceae)
Biochim. Biophys. Acta
1216
31-42
1993
Saponaria officinalis
Bolognesi, A.; Olivieri, F.; Battelli, M.G.; Barbieri, L.; Falasca, A.I.; Parente, A.; Del Vecchio Blanco, F.; Stirpe, F.
Ribosome-inactivating proteins (RNA N-glycosidases) from the seeds of Saponaria ocymoides and Vaccaria pyramidata
Eur. J. Biochem.
228
935-940
1995
Saponaria ocymoides, Gypsophila vaccaria
Brigotti, M.; Carnicelli, D.; Alvergna, P.; Pallanca, A.; Lorenzetti, R.; Denaro, M.; Sperti, S.; Montanaro, L.
3-immature tRNA(Trp) is required for ribosome inactivation by gelonin,a plant RNA N-glycosidase
Biochem. J.
310
249-253
1995
Suregada multiflora
Ling, J.; Liu, W.Y.; Wang, T.P.
Simultaneous existence of two types of ribosome-inactivating proteins in the seeds of Cinnamonum camphora-characterization of the enzymatic activities of these cytotoxic proteins
Biochim. Biophys. Acta
1252
15-22
1995
Cinnamomum camphora
Barbieri, L.; Valbonesi, P.; Gorini, P.; Pession, A.; Stirpe, F.
Polynucleotide: adenosine glycosidase activity of saporin-L1: effect on DNA, RNA and poly(A)
Biochem. J.
319
507-513
1996
Saponaria officinalis
Brigotti, M.; Carnicelli, D.; Alvergna, P.; Pallanca, A.; Sperti, S.; Montanaro, L.
tRNA(Trp) as cofactor of gelonin, a ribosome-inactivating protein with RNA-N-glycosidase activity. Features required for the cofactor activity
Biochem. Mol. Biol. Int.
40
181-188
1996
Suregada multiflora
Li, X.d.; Liu, W.y.; Niu, C.I.
Purification of a new ribosome-inactivating protein from the seeds of Cinnamomum porrectum and characterization of the RNA N-glycosidase activity of the toxic protein
Biol. Chem.
377
825-831
1996
Cinnamomum parthenoxylon
Yoshinari, S.; Yokota, S.; Sawamoto, H.; Koresawa, S.; Tamura, M.; Endo, Y.
Purification, characterization and subcellular localization of a type-1 ribosome-inactivating protein from the sarcocarp of Cucurbita pepo
Eur. J. Biochem.
242
585-591
1996
Cucurbita pepo
Brigotti, M.; Carnicelli, D.; Alvergna, P.; Mazzaracchio, R.; Sperti, S.; Montanaro, L.
The RNA-N-glycosidase activity of Shiga-like toxin I: kinetic parameters of the native and activated toxin
Toxicon
35
1431-1437
1997
Escherichia coli
Rojo, M.A.; Yato, M.; Ishii-Minami, N.; Minami, E.; Kaku, H.; Citores, L.; Girbes, T.; Shibuya, N.
Isolation, cDNA cloning, biological properties, and carbohydrate binding specificity of sieboldin-b, a type II ribosome-inactivating protein from the bark of Japanese elderberry (Sambucus sieboldiana)
Arch. Biochem. Biophys.
340
185-194
1997
Sambucus racemosa subsp. sieboldiana
Yoshinari, S.; Koresawa, S.; Yokota, S.; Sawamoto, H.; Tamura, M.; Endo, Y.
Gypsophilin, a new type 1 ribosome-inactivating protein from Gypsophila elegans: purification, enzymic characterization, and subcellular localization
Biosci. Biotechnol. Biochem.
61
324-331
1997
Gypsophila elegans
Lam, S.S.L.; Wang, H.; Ng, T.B.
Purification and characterization of novel ribosome inactivating proteins, alpha- and beta-pisavins, from seeds of the garden pea Pisum sativum
Biochem. Biophys. Res. Commun.
253
135-142
1998
Pisum sativum
Pu, Z.; Xie, L.; Wang, E.d.; Liu, W.Y.
Purification and activity study of the A- and B-chains of cinnamomin, a type II ribosome-inactivating protein
Biol. Chem.
379
1413-1418
1998
Cinnamomum camphora
de Benito, F.M.; Iglesias, R.; Ferreras, J.M.; Citores, L.; Camafeita, E.; Mendez, E.; Girbes, T.
Constitutive and inducible type 1 ribosome-inactivating proteins (RIPs) in elderberry (Sambucus nigra L.)
FEBS Lett.
428
75-79
1998
Sambucus nigra
Chen, R.; Xu, Y.z.; Wu, J.; Pu, Z.; Jin, S.w.; Liu, W.y.; Xia, Z.x.
Purification and characterization of trichomaglin: a novel ribosome-inactivating protein with abortifacient activity
Biochem. Mol. Biol. Int.
47
185-193
1999
Trichosanthes lepiniate
Chow, L.P.; Chou, M.H.; Ho, C.Y.; Chuang, C.C.; Pan, F.M.; Wu, S.H.; Lin, J.Y.
Purification, characterization and molecular cloning of trichoanguin, a novel type I ribosome-inactivating protein from the seeds of Trichosanthes anguina
Biochem. J.
328
211-219
1999
Trichosanthes anguina
-
Yan, L.; Wu, S.; Li, H.G.; Li, J.H.; Wong, R.N.S.; Shi, Q.L.; Dong, Y.C.
Role of TYR70 in the N-glycosidase activity of neo-trichosanthin
Toxicon
37
961-972
1999
Trichosanthes sp.
Barbieri, L.; Valbonesi, P.; Righi, F.; Zuccheri, G.; Monti, F.; Gorini, P.; Samori, B.; Stirpe, F.
Polynucleotide:Adenosine glycosidase is the sole activity of ribosome-inactivating proteins on DNA
J. Biochem.
128
883-889
2000
Suregada multiflora, Momordica charantia, Phytolacca americana, Saponaria officinalis
Gu, Y.J.; Xia, Z.X.
Crystal structures of the complexes of trichosanthin with four substrate analogs and catalytic mechanism of RNA N-glycosidase
Proteins
39
37-46
2000
Trichosanthes sp.
Chi, P.V.; Truong, H.Q.; Ha, N.T.; Chung, W.I.; Binh, L.T.
Characterization of trichobakin, a type I ribosome-inactivating protein from Trichosanthes sp. Bac Kan 8-98
Biotechnol. Appl. Biochem.
34
85-92
2001
Trichosanthes sp.
Peumans, W.J.; Hao, Q.; Van Damme, E.J.
Ribosome-inactivating proteins from plants: more than RNA N-glycosidases?
FASEB J.
15
1493-1506
2001
Abrus precatorius, Eranthis hyemalis, Hordeum vulgare, Momordica charantia, no activity in Arabidopsis thaliana, Phytolacca americana, Phytolacca insularis, Ricinus communis, Saponaria officinalis, Suregada multiflora, Trichosanthes kirilowii, Trichosanthes sp.
Tsang, K.Y.; Ng, T.B.
Isolation and characterization of a new ribosome inactivating protein, momorgrosvin, from seeds of the monk's fruit Momordica grosvenorii
Life Sci.
68
773-784
2001
Siraitia grosvenorii
Xie, L.; Wang, B.Z.; Hu, R.G.; Ji, H.B.; Zhang, L.; Liu, W.Y.
Structural and functional studies of cinnamomin, a new type II ribosome-inactivating protein isolated from the seeds of the camphor tree
Eur. J. Biochem.
268
5723-5733
2001
Cinnamomum camphora
Zhang, A.H.; Tang, S.; Liu, W.y.
Substrate-structure dependence of ribotoxins on cleaving RNA in C. camphora ribosome
J. Nat. Toxins
10
119-125
2001
Ricinus communis, Cinnamomum camphora
Honjo, E.; Watanabe, K.; Tsukamoto, T.
Real-time kinetic analyses of the interaction of ricin toxin A-chain with ribosomes prove a conformational change involved in complex formation
J. Biochem.
131
267-275
2002
Ricinus communis
Krauspenhaar, R.; Rypniewski, W.; Kalkura, N.; Moore, K.; DeLucas, L.; Stoeva, S.; Mikhailov, A.; Voelter, W.; Betzel, C.
Crystallization under microgravity of mistletoe lectin I from Viscum album with adenine monophosphate and the crystal structure at 1.9.ANG. resolution
Acta Crystallogr. Sect. D
58
1704-1707
2002
Viscum album (P81446), Viscum album
Liu, R.S.; Yang, J.H.; Liu, W.Y.
Isolation and enzymatic characterization of lamjapin, the first ribosome-inactivating protein from cryptogamic algal plant (Laminaria japonica A)
Eur. J. Biochem.
269
4746-4752
2002
Saccharina japonica
Ng, T.B.; Parkash, A.
Hispin, a novel ribosome inactivating protein with antifungal activity from hairy melon seeds
Protein Expr. Purif.
26
211-217
2002
Benincasa hispida
Bagga, S.; Seth, D.; Batra, J.K.
The cytotoxic activity of ribosome-inactivating protein saporin-6 is attributed to its rRNA N-glycosidase and internucleosomal DNA fragmentation activities
J. Biol. Chem.
278
4813-4820
2003
Saponaria officinalis
Guo, Q.; Zhou, W.; Too, H.M.; Li, J.; Liu, Y.; Bartlam, M.; Dong, Y.; Wong, K.B.; Shaw, P.C.; Rao, Z.
Substrate binding and catalysis in trichosanthin occur in different sites as revealed by the complex structures of several E85 mutants
Protein Eng.
16
391-396
2003
Trichosanthes sp.
Li, F.; Yang, X.x.; Xia, H.c.; Zeng, R.; Hu, W.g.; Li, Z.; Zhang, Z.c.
Purification and characterization of Luffin P1, a ribosome-inactivating peptide from the seeds of Luffa cylindrica
Peptides
24
799-805
2003
Luffa aegyptiaca
Zhao, Y.; Wang, X.; Zhou, G.; Li, H.
A pokeweed antiviral protein gene in roots of Phytolacca americana
Acta Virol.
48
131-132
2004
Phytolacca americana (P93444), Phytolacca americana (Q40772), Phytolacca americana (Q53YN2), Phytolacca americana (Q8RYA4), Phytolacca americana
Wang, B.Z.; Zou, W.G.; Liu, W.Y.; Liu, X.Y.
The lower cytotoxicity of cinnamomin (a type II RIP) is due to its B-chain
Arch. Biochem. Biophys.
451
91-96
2006
Ricinus communis, Cinnamomum camphora
Daubenfeld, T.; Hossann, M.; Trommer, W.E.; Niedner-Schatteburg, G.
On the contentious sequence and glycosylation motif of the ribosome inactivating plant protein gelonin
Biochem. Biophys. Res. Commun.
333
984-989
2005
Suregada multiflora
Muething, J.; Meisen, I.; Bulau, P.; Langer, M.; Witthohn, K.; Lentzen, H.; Neumann, U.; Peter-Katalinic, J.
Mistletoe lectin I is a sialic acid-specific lectin with strict preference to gangliosides and glycoproteins with terminal Neu5Ac alpha 2-6Gal beta 1-4GlcNAc residues
Biochemistry
43
2996-3007
2004
Viscum album
Amukele, T.K.; Schramm, V.L.
Ricin A-chain substrate specificity in RNA, DNA, and hybrid stem-loop structures
Biochemistry
43
4913-4922
2004
Ricinus communis
Roday, S.; Amukele, T.; Evans, G.B.; Tyler, P.C.; Furneaux, R.H.; Schramm, V.L.
Inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state
Biochemistry
43
4923-4933
2004
Ricinus communis
Parikh, B.A.; Baykal, U.; Di, R.; Tumer, N.E.
Evidence for retro-translocation of pokeweed antiviral protein from endoplasmic reticulum into cytosol and separation of its activity on ribosomes from its activity on capped RNA
Biochemistry
44
2478-2490
2005
Phytolacca americana (P10297)
Amukele, T.K.; Roday, S.; Schramm, V.L.
Ricin A-chain activity on stem-loop and unstructured DNA substrates
Biochemistry
44
4416-4425
2005
Ricinus communis
Pevzner, I.B.; Agapov, II; Pfueller, U.; Pfueller, K.; Maluchenko, N.V.; Moisenovich, M.M.; Tonevitsky, A.G.; Kirpichnikov, M.P.
Cloning and expression of mistletoe lectin III B-subunit
Biochemistry (Moscow)
70
306-315
2005
Viscum album
Yamasaki, C.; Nishikawa, K.; Zeng, X.T.; Katayama, Y.; Natori, Y.; Komatsu, N.; Oda, T.
Induction of cytokines by toxins that have an identical RNA N-glycosidase activity: Shiga toxin, ricin, and modeccin
Biochim. Biophys. Acta
1671
44-50
2004
Ricinus communis, Corynebacterium diphtheriae, Shigella dysenteriae, Adenia digitata
Pevzner, I.B.; Agapov, II; Niwa, H.; Maluchenko, N.V.; Moisenovich, M.M.; Pfuller, U.; Tonevitsky, A.G.
Differences in amino acid sequences of mistletoe lectin I and III B-subunits determining carbohydrate binding specificity
Biochim. Biophys. Acta
1675
155-164
2004
Viscum album
Hartley, M.R.; Lord, J.M.
Cytotoxic ribosome-inactivating lectins from plants
Biochim. Biophys. Acta
1701
1-14
2004
Abrus precatorius, Cucurbita pepo, Dianthus caryophyllus, Escherichia coli, Mirabilis jalapa, Momordica charantia, Phytolacca americana, Sambucus nigra, Saponaria officinalis, Shigella dysenteriae, Trichosanthes kirilowii, Triticum aestivum, Viscum album, Adenia volkensii, Sambucus ebulus, Ricinus communis (P02879)
Wang, L.C.; Kang, L.; Hu, T.M.; Wang, J.L.
Abrin-a A chain expressed as soluble form in Escherichia coli from a PCR-synthesized gene is catalytically and functionally active
Biochimie
86
327-333
2004
Abrus precatorius (Q7DM12)
Tomatsu, M.; Kondo, T.; Yoshikawa, T.; Komeno, T.; Adachi, N.; Kawasaki, Y.; Ikuta, A.; Tashiro, F.
An apoptotic inducer, aralin, is a novel type II ribosome-inactivating protein from Aralia elata
Biol. Chem.
385
819-827
2004
Aralia elata
Kondo, T.; Kurihara, S.; Yoshikawa, T.; Mizukami, H.
Effect of N- and C-terminal deletions on the RNA N-glycosidase activity and the antigenicity of karasurin-A, a ribosome-inactivating protein from Trichosanthes kirilowii var. japonica
Biotechnol. Lett.
26
1873-1878
2004
Trichosanthes kirilowii var. japonica
Uckun, F.M.; Rustamova, L.; Vassilev, A.O.; Tibbles, H.E.; Petkevich, A.S.
CNS activity of pokeweed anti-viral protein (PAP) in mice infected with lymphocytic choriomeningitis virus (LCMV)
BMC Infect. Dis.
5
9
2005
Phytolacca americana
Battelli, M.G.; Musiani, S.; Buonamici, L.; Santi, S.; Riccio, M.; Maraldi, N.M.; Girbes, T.; Stirpe, F.
Interaction of volkensin with HeLa cells: binding, uptake, intracellular localization, degradation and exocytosis
Cell. Mol. Life Sci.
61
1975-1984
2004
Sambucus nigra, Adenia volkensii
Sestili, P.; Alfieri, R.; Carnicelli, D.; Martinelli, C.; Barbieri, L.; Stirpe, F.; Bonelli, M.; Petronini, P.G.; Brigotti, M.
Shiga toxin 1 and ricin inhibit the repair of H2O2-induced DNA single strand breaks in cultured mammalian cells
DNA Repair
4
271-277
2005
Ricinus communis, Shigella dysenteriae
Krawetz, J.E.; Boston, R.S.
Substrate specificity of a maize ribosome-inactivating protein differs across diverse taxa
Eur. J. Biochem.
267
1966-1974
2000
Zea mays (P25891), Zea mays
Vandenbussche, F.; Desmyter, S.; Ciani, M.; Proost, P.; Peumans, W.J.; Van Damme, E.J.
Analysis of the in planta antiviral activity of elderberry ribosome-inactivating proteins
Eur. J. Biochem.
271
1508-1515
2004
Sambucus nigra
Marsden, C.J.; Fueloep, V.; Day, P.J.; Lord, J.M.
The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain
Eur. J. Biochem.
271
153-162
2004
Ricinus communis
Park, S.W.; Vepachedu, R.; Owens, R.A.; Vivanco, J.M.
The N-glycosidase activity of the ribosome-inactivating protein ME1 targets single-stranded regions of nucleic acids independent of sequence or structural motifs
J. Biol. Chem.
279
34165-34174
2004
Mirabilis expansa
Picard, D.; Kao, C.C.; Hudak, K.A.
Pokeweed antiviral protein inhibits brome mosaic virus replication in plant cells
J. Biol. Chem.
280
20069-20075
2005
Phytolacca americana
Zhang, C.; Medina-Bolivar, F.; Buswell, S.; Cramer, C.L.
Purification and stabilization of ricin B from tobacco hairy root culture medium by aqueous two-phase extraction
J. Biotechnol.
117
39-48
2005
Ricinus communis
Bass, H.W.; Krawetz, J.E.; GR, O.B.; Zinselmeier, C.; Habben, J.E.; Boston, R.S.
Maize ribosome-inactivating proteins (RIPs) with distinct expression patterns have similar requirements for proenzyme activation
J. Exp. Bot.
55
2219-2233
2004
Zea mays, Zea mays (P25891)
Poma, A.; Spano, L.; Pittaluga, E.; Tucci, A.; Palladino, L.; Limongi, T.
Interactions between saporin, a ribosome-inactivating protein, and DNA: a study by atomic force microscopy
J. Microsc.
217
69-74
2005
Saponaria officinalis
Polito, L.; Bolognesi, A.; Tazzari, P.L.; Farini, V.; Lubelli, C.; Zinzani, P.L.; Ricci, F.; Stirpe, F.
The conjugate Rituximab/saporin-S6 completely inhibits clonogenic growth of CD20-expressing cells and produces a synergistic toxic effect with Fludarabine
Leukemia
18
1215-1222
2004
Saponaria officinalis
Park, J.S.; Hwang, D.J.; Lee, S.M.; Kim, Y.T.; Choi, S.B.; Cho, K.J.
Ribosome-inactivating activity and cDNA cloning of antiviral protein isoforms of Chenopodium album
Mol. Cells
17
73-80
2004
Chenopodium album
Wang, S.; Feng, J.; Guo, J.; Guo, L.; Li, Y.; Sun, Y.; Qin, W.; Hu, M.; Han, G.; Shen, B.
A novel designed single domain antibody on 3-D-structure of ricin A chain remarkably blocked ricin-induced cytotoxicity
Mol. Immunol.
43
1912-1919
2006
Ricinus communis
Wang, M.; Hudak, K.A.
A novel interaction of pokeweed antiviral protein with translation initiation factors 4G and iso4G: a potential indirect mechanism to access viral RNAs
Nucleic Acids Res.
34
1174-1181
2006
Phytolacca americana
Sharma, N.; Park, S.W.; Vepachedu, R.; Barbieri, L.; Ciani, M.; Stirpe, F.; Savary, B.J.; Vivanco, J.M.
Isolation and characterization of an RIP (ribosome-inactivating protein)-like protein from tobacco with dual enzymatic activity
Plant Physiol.
134
171-181
2004
Nicotiana tabacum
Vandenbussche, F.; Peumans, W.J.; Desmyter, S.; Proost, P.; Ciani, M.; Van Damme, E.J.
The type-1 and type-2 ribosome-inactivating proteins from Iris confer transgenic tobacco plants local but not systemic protection against viruses
Planta
220
211-221
2004
Iris sp.
Guo, C.; Li, Z.; Shi, Y.; Xu, M.; Wise, J.G.; Trommer, W.E.; Yuan, J.
Intein-mediated fusion expression, high efficient refolding, and one-step purification of gelonin toxin
Protein Expr. Purif.
37
361-367
2004
Suregada multiflora
Vepachedu, R.; Park, S.W.; Sharma, N.; Vivanco, J.M.
Bacterial expression and enzymatic activity analysis of ME1, a ribosome-inactivating protein from Mirabilis expansa
Protein Expr. Purif.
40
142-151
2005
Mirabilis expansa (Q8GV51), Mirabilis expansa
Stirpe, F.
Ribosome-inactivating proteins
Toxicon
44
371-383
2004
Abrus precatorius, Ricinus communis, Suregada multiflora, Hordeum vulgare, Phytolacca americana, Sambucus nigra, Saponaria officinalis, Shigella dysenteriae, Trichosanthes kirilowii, Viscum album, Zea mays, Phoradendron californicum, Adenia volkensii, Adenia digitata, Mirabilis expansa
Gasperi-Campani, A.; Brognara, I.; Baiocchi, D.; Roncuzzi, L.
Mitochondrial DNA D-loop as a new target of saporin 6 nuclease activity
Toxicon
45
475-480
2005
Saponaria officinalis
Marsden, C.J.; Knight, S.; Smith, D.C.; Day, P.J.; Roberts, L.M.; Phillips, G.J.; Lord, J.M.
Insertional mutagenesis of ricin A chain: a novel route to an anti-ricin vaccine
Vaccine
22
2800-2805
2004
Ricinus communis
Fraser, M.E.; Cherney, M.M.; Marcato, P.; Mulvey, G.L.; Armstrong, G.D.; James, M.N.
Binding of adenine to Stx2, the protein toxin from Escherichia coli O157:H7
Acta Crystallogr. Sect. F
62
627-630
2006
Escherichia coli
Wang, H.B.; Xia, F.; Ge, J.; Yin, J.; Tan, L.S.; Zhang, P.D.; Zhong, J.
Co-application of ricin A chain and a recombinant adenovirus expressing ricin B chain as a novel approach for cancer therapy
Acta Pharmacol. Sin.
28
657-662
2007
Ricinus communis
Wang, T.; Zou, Y.S.; Zhu, D.W.; Azzi, A.; Liu, W.Y.; Lin, S.X.
Cinnamomin: separation, crystallization and preliminary X-ray diffraction study
Amino Acids
34
239-243
2008
Cinnamomum camphora
Lubelli, C.; Chatgilialoglu, A.; Bolognesi, A.; Strocchi, P.; Colombatti, M.; Stirpe, F.
Detection of ricin and other ribosome-inactivating proteins by an immuno-polymerase chain reaction assay
Anal. Biochem.
355
102-109
2006
Ricinus communis, Dianthus caryophyllus
Keener, W.K.; Rivera, V.R.; Young, C.C.; Poli, M.A.
An activity-dependent assay for ricin and related RNA N-glycosidases based on electrochemiluminescence
Anal. Biochem.
357
200-207
2006
Abrus precatorius, Ricinus communis, Saponaria officinalis
Haes, A.J.; Giordano, B.C.; Collins, G.E.
Aptamer-based detection and quantitative analysis of ricin using affinity probe capillary electrophoresis
Anal. Chem.
78
3758-3764
2006
Ricinus communis
Mei, Q.; Fredrickson, C.K.; Lian, W.; Jin, S.; Fan, Z.H.
Ricin detection by biological signal amplification in a well-in-a-well device
Anal. Chem.
78
7659-7664
2006
Ricinus communis
Becher, F.; Duriez, E.; Volland, H.; Tabet, J.C.; Ezan, E.
Detection of functional ricin by immunoaffinity and liquid chromatography-tandem mass spectrometry
Anal. Chem.
79
659-665
2007
Ricinus communis
Liu, Q.; Zhan, J.; Chen, X.; Zheng, S.
Ricin A chain reaches the endoplasmic reticulum after endocytosis
Biochem. Biophys. Res. Commun.
343
857-863
2006
Ricinus communis
Ayub, M.J.; Smulski, C.R.; Ma, K.W.; Levin, M.J.; Shaw, P.C.; Wong, K.B.
The C-terminal end of P proteins mediates ribosome inactivation by trichosanthin but does not affect the pokeweed antiviral protein activity
Biochem. Biophys. Res. Commun.
369
314-319
2008
Trichosanthes kirilowii (P09989), Phytolacca americana (P10297)
Roday, S.; Saen-oon, S.; Schramm, V.L.
Vinyldeoxyadenosine in a sarcin-ricin RNA loop and its binding to ricin toxin A-chain
Biochemistry
46
6169-6182
2007
Phytolacca americana, Ricinus communis (P02879)
De-la-Pena, C.; Badri, D.V.; Vivanco, J.M.
Novel role for pectin methylesterase in Arabidopsis: A new function showing ribosome-inactivating protein (RIP) activity
Biochim. Biophys. Acta
1780
773-783
2008
Arabidopsis thaliana
Hartley, P.G.; Alderton, M.R.; Dawson, R.M.; Wells, D.
Ricin antitoxins based on lyotropic mesophases containing galactose amphiphiles
Bioconjug. Chem.
18
152-159
2007
Ricinus communis
Chuethong, J.; Oda, K.; Sakurai, H.; Saiki, I.; Leelamanit, W.
Cochinin B, a novel ribosome-inactivating protein from the seeds of Momordica cochinchinensis
Biol. Pharm. Bull.
30
428-432
2007
Momordica cochinchinensis
Ganguly, D.; Mukhopadhyay, C.
Binding diversity of the two binding sites of ricin B lectin
Biopolymers
83
83-94
2006
Ricinus communis (P02879)
Ganguly, D.; Mukhopadhyay, C.
Extended binding site of ricin B lectin for oligosaccharide recognition
Biopolymers
86
311-320
2007
Ricinus communis (P02879)
Olson, M.A.; Yeh, I.C.; Lee, M.S.
Coarse-grained lattice model simulations of sequence-structure fitness of a ribosome-inactivating protein
Biopolymers
89
153-159
2008
Ricinus communis
Tang, J.; Yu, T.; Guo, L.; Xie, J.; Shao, N.; He, Z.
In vitro selection of DNA aptamer against abrin toxin and aptamer-based abrin direct detection
Biosens. Bioelectron.
22
2456-2463
2007
Abrus precatorius
Anderson, G.P.; Matney, R.; Liu, J.L.; Hayhurst, A.; Goldman, E.R.
Multiplexed fluid array screening of phage displayed anti-ricin single domain antibodies for rapid assessment of specificity
Biotechniques
43
806-811
2007
Ricinus communis
Xu, J.; Wang, H.; Fan, J.
Expression of a ribosome-inactivating protein gene in bitter melon is induced by Sphaerotheca fuliginea and abiotic stimuli
Biotechnol. Lett.
29
1605-1610
2007
Momordica charantia (P24817), Momordica charantia
Wang, Y.; Guo, L.; Zhao, K.; Chen, J.; Feng, J.; Sun, Y.; Li, Y.; Shen, B.
Novel chimeric anti-ricin antibody C4C13 with neutralizing activity against ricin toxicity
Biotechnol. Lett.
29
1811-1816
2007
Ricinus communis
Nimmanapalli, R.; Lyu, M.A.; Du, M.; Keating, M.J.; Rosenblum, M.G.; Gandhi, V.
The growth factor fusion construct containing B-lymphocyte stimulator (BLyS) and the toxin rGel induces apoptosis specifically in BAFF-R-positive CLL cells
Blood
109
2557-2564
2007
Suregada multiflora
Hess, P.R.; Barnes, C.; Woolard, M.D.; Johnson, M.D.; Cullen, J.M.; Collins, E.J.; Frelinger, J.A.
Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin
Blood
109
3300-3307
2007
Saponaria officinalis
Hou, X.; Chen, M.; Chen, L.; Meehan, E.J.; Xie, J.; Huang, M.
X-ray sequence and crystal structure of luffaculin 1, a novel type 1 ribosome-inactivating protein
BMC Struct. Biol.
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29
2007
Luffa acutangula
Carra, J.H.; McHugh, C.A.; Mulligan, S.; Machiesky, L.M.; Soares, A.S.; Millard, C.B.
Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site
BMC Struct. Biol.
7
72
2007
Ricinus communis (P02879)
Munoz, R.; Arias, Y.; Ferreras, J.M.; Rojo, M.A.; Gayoso, M.J.; Nocito, M.; Benitez, J.; Jimenez, P.; Bernabeu, C.; Girbes, T.
Targeting a marker of the tumour neovasculature using a novel anti-human CD105-immunotoxin containing the non-toxic type 2 ribosome-inactivating protein nigrin b
Cancer Lett.
256
73-80
2007
Sambucus nigra
Jandhyala, D.M.; Ahluwalia, A.; Obrig, T.; Thorpe, C.M.
ZAK: a MAP3Kinase that transduces Shiga toxin and ricin induced proinflammatory cytokine expression
Cell. Microbiol.
10
1468-1477
2008
Ricinus communis, Escherichia coli
Tang, J.; Xie, J.; Shao, N.; Yan, Y.
The DNA aptamers that specifically recognize ricin toxin are selected by two in vitro selection methods
Electrophoresis
27
1303-1311
2006
Ricinus communis (P02879)
Bachran, C.; Sutherland, M.; Heisler, I.; Hebestreit, P.; Melzig, M.F.; Fuchs, H.
The saponin-mediated enhanced uptake of targeted saporin-based drugs is strongly dependent on the saponin structure
Exp. Biol. Med.
231
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2006
Saponaria officinalis
Pratt, T.S.; Pincus, S.H.; Hale, M.L.; Moreira, A.L.; Roy, C.J.; Tchou-Wong, K.M.
Oropharyngeal aspiration of ricin as a lung challenge model for evaluation of the therapeutic index of antibodies against ricin A-chain for post-exposure treatment
Exp. Lung Res.
33
459-481
2007
Ricinus communis
Geden, S.E.; Gardner, R.A.; Fabbrini, M.S.; Ohashi, M.; Phanstiel Iv, O.; Teter, K.
Lipopolyamine treatment increases the efficacy of intoxication with saporin and an anticancer saporin conjugate
FEBS J.
274
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2007
Saponaria officinalis
Xu, L.; Wang, Y.; Wang, L.; Gao, Y.; An, C.
TYchi, a novel chitinase with RNA N-glycosidase and anti-tumor activities
Front. Biosci.
13
3127-3135
2008
Trichosanthes kirilowii
Mantis, N.J.; McGuinness, C.R.; Sonuyi, O.; Edwards, G.; Farrant, S.A.
Immunoglobulin A antibodies against ricin A and B subunits protect epithelial cells from ricin intoxication
Infect. Immun.
74
3455-3462
2006
Ricinus communis
Li, X.P.; Baricevic, M.; Saidasan, H.; Tumer, N.E.
Ribosome depurination is not sufficient for ricin-mediated cell death in Saccharomyces cerevisiae
Infect. Immun.
75
417-428
2007
Ricinus communis
Rathore, S.S.; Ghosh, P.C.
Effect of surface charge and density of distearylphosphatidylethanolamine-mPEG-2000 (DSPE-mPEG-2000) on the cytotoxicity of liposome-entrapped ricin: effect of lysosomotropic agents
Int. J. Pharm.
350
79-94
2008
Ricinus communis
Bharadwaj, S.; Rathore, S.S.; Ghosh, P.C.
Enhancement of the cytotoxicity of liposomal ricin by the carboxylic ionophore monensin and the lysosomotropic amine NH4Cl in Chinese hamster ovary cells
Int. J. Toxicol.
25
349-359
2006
Ricinus communis
Jackson, L.S.; Tolleson, W.H.; Chirtel, S.J.
Thermal inactivation of ricin using infant formula as a food matrix
J. Agric. Food Chem.
54
7300-7304
2006
Ricinus communis
Sturm, M.B.; Roday, S.; Schramm, V.L.
Circular DNA and DNA/RNA hybrid molecules as scaffolds for ricin inhibitor design
J. Am. Chem. Soc.
129
5544-5550
2007
Ricinus communis
Lindsey, C.Y.; Richardson, J.D.; Brown, J.E.; Hale, M.L.
Intralaboratory validation of cell-free translation assay for detecting ricin toxin biological activity
J. AOAC Int.
90
1316-1325
2007
Ricinus communis
Dawson, R.M.; Alderton, M.R.; Wells, D.; Hartley, P.G.
Monovalent and polyvalent carbohydrate inhibitors of ricin binding to a model of the cell-surface receptor
J. Appl. Toxicol.
26
247-252
2006
Ricinus communis
Fukunaga, Y.; Nishimoto, E.; Yamashita, K.; Otosu, T.; Yamashita, S.
The partially unfolded state of beta-momorcharin characterized with steady-state and time-resolved fluorescence studies
J. Biochem.
141
9-18
2007
Momordica charantia
Ye, W.; Nanga, R.P.; Kang, C.B.; Song, J.H.; Song, S.K.; Yoon, H.S.
Molecular characterization of the recombinant A-chain of a type II ribosome-inactivating protein (RIP) from Viscum album coloratum and structural basis on its ribosome-inactivating activity and the sugar-binding properties of the B-chain
J. Biochem. Mol. Biol.
39
560-570
2006
Viscum album
Jolliffe, N.A.; Di Cola, A.; Marsden, C.J.; Lord, J.M.; Ceriotti, A.; Frigerio, L.; Roberts, L.M.
The N-terminal ricin propeptide influences the fate of ricin A-chain in tobacco protoplasts
J. Biol. Chem.
281
23377-23385
2006
Ricinus communis
Parikh, B.A.; Tortora, A.; Li, X.P.; Tumer, N.E.
Ricin inhibits activation of the unfolded protein response by preventing splicing of the HAC1 mRNA
J. Biol. Chem.
283
6145-6153
2008
Ricinus communis
Bolognesi, A.; Polito, L.; Farini, V.; Bortolotti, M.; Tazzari, P.L.; Ratta, M.; Ravaioli, A.; Horenstein, A.L.; Stirpe, F.; Battelli, M.G.; Malavasi, F.
CD38 as a target of IB4 mAb carrying saporin-S6: design of an immunotoxin for ex vivo depletion of hematological CD38+ neoplasia
J. Biol. Regul. Homeost. Agents
19
145-152
2006
Saponaria officinalis
Fulton, R.E.; Thompson, H.G.
Fluorogenic hand-held immunoassay for the identification of ricin - rapid analyte measurement platform
J. Immunoassay Immunochem.
28
227-241
2007
Ricinus communis
McCluskey, A.J.; Poon, G.M.; Bolewska-Pedyczak, E.; Srikumar, T.; Jeram, S.M.; Raught, B.; Gariepy, J.
The catalytic subunit of Shiga-like toxin 1 interacts with ribosomal stalk proteins and is inhibited by their conserved C-terminal domain
J. Mol. Biol.
378
375-386
2008
Escherichia coli
Kondo, T.; Yoshikawa, T.
Purification and characterization of abelesculin, a novel ribosome-inactivating protein from the mature seeds of Abelmoschus esculentus
J. Nat. Med.
61
170-174
2007
Abelmoschus esculentus
-
Mouser, P.; Filigenzi, M.S.; Puschner, B.; Johnson, V.; Miller, M.A.; Hooser, S.B.
Fatal ricin toxicosis in a puppy confirmed by liquid chromatography/mass spectrometry when using ricinine as a marker
J. Vet. Diagn. Invest.
19
216-220
2007
Ricinus communis
Slominska-Wojewodzka, M.; Gregers, T.F.; Waelchli, S.; Sandvig, K.
EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol
Mol. Biol. Cell
17
1664-1675
2006
Ricinus communis
Gonzalez, T.V.; Farrant, S.A.; Mantis, N.J.
Ricin induces IL-8 secretion from human monocyte/macrophages by activating the p38 MAP kinase pathway
Mol. Immunol.
43
1920-1923
2006
Ricinus communis
Grimaldi, E.; Claassen, E.A.; Michael Lord, J.; Smith, D.C.; Easton, A.J.
Stimulation of pneumovirus-specific CD8+ T-cells using a non-toxic recombinant ricin delivery system
Mol. Immunol.
44
993-998
2007
Mus musculus
Chakravartula, S.V.; Guttarla, N.
Amino acids of ricin and its polypeptides
Nat. Prod. Res.
22
258-263
2008
Ricinus communis
Chan, D.S.; Chu, L.O.; Lee, K.M.; Too, P.H.; Ma, K.W.; Sze, K.H.; Zhu, G.; Shaw, P.C.; Wong, K.B.
Interaction between trichosanthin, a ribosome-inactivating protein, and the ribosomal stalk protein P2 by chemical shift perturbation and mutagenesis analyses
Nucleic Acids Res.
35
1660-1672
2007
Trichosanthes kirilowii (P09989)
Mak, A.N.; Wong, Y.T.; An, Y.J.; Cha, S.S.; Sze, K.H.; Au, S.W.; Wong, K.B.; Shaw, P.C.
Structure-function study of maize ribosome-inactivating protein: implications for the internal inactivation region and the sole glutamate in the active site
Nucleic Acids Res.
35
6259-6267
2007
Zea mays
Gaigalas, A.K.; Cole, K.D.; Bykadi, S.; Wang, L.; DeRose, P.
Photophysical properties of ricin
Photochem. Photobiol.
83
1149-1156
2007
Ricinus communis
Baykal, U.; Tumer, N.E.
The C-terminus of pokeweed antiviral protein has distinct roles in transport to the cytosol, ribosome depurination and cytotoxicity
Plant J.
49
995-1007
2007
Phytolacca americana
Vitetta, E.S.; Smallshaw, J.E.; Coleman, E.; Jafri, H.; Foster, C.; Munford, R.; Schindler, J.
A pilot clinical trial of a recombinant ricin vaccine in normal humans
Proc. Natl. Acad. Sci. USA
103
2268-2273
2006
Ricinus communis
Chambery, A.; Severino, V.; Stirpe, F.; Parente, A.
Cloning and expression of the B chain of volkensin, type 2 ribosome inactivating protein from Adenia volkensii harms: co-folding with the A chain for heterodimer reconstitution
Protein Expr. Purif.
51
209-215
2007
Adenia volkensii
Ruggieroa, A.; Chambery, A.; Di Maro, A.; Mastroianni, A.; Parente, A.; Berisio, R.
Crystallization and preliminary X-ray diffraction analysis of PD-L1, a highly glycosylated ribosome inactivating protein with DNase activity
Protein Pept. Lett.
14
407-409
2007
Phytolacca dioica
Chambery, A.; Pisante, M.; Di Maro, A.; Di Zazzo, E.; Ruvo, M.; Costantini, S.; Colonna, G.; Parente, A.
Invariant Ser211 is involved in the catalysis of PD-L4, type I RIP from Phytolacca dioica leaves
Proteins
67
209-218
2007
Phytolacca dioica (P84854), Phytolacca dioica
Mansouri, S.; Nourollahzadeh, E.; Hudak, K.A.
Pokeweed antiviral protein depurinates the sarcin/ricin loop of the rRNA prior to binding of aminoacyl-tRNA to the ribosomal A-site
RNA
12
1683-1692
2006
Phytolacca americana
Korennykh, A.V.; Correll, C.C.; Piccirilli, J.A.
Evidence for the importance of electrostatics in the function of two distinct families of ribosome inactivating toxins
RNA
13
1391-1396
2007
Ricinus communis, Saponaria officinalis
Sha, O.; Kwong, W.H.; Pang Cho, E.Y.; Wai Yew, D.T.; Ng, T.B.
Different neuronal toxicity of single-chain ribosome-inactivating proteins on the rat retina
Toxicon
51
45-53
2008
Ricinus communis, Trichosanthes kirilowii
Grimmer, S.; Spilsberg, B.; Hanada, K.; Sandvig, K.
Depletion of sphingolipids facilitates endosome to Golgi transport of ricin
Traffic
7
1243-1253
2006
Ricinus communis
Utskarpen, A.; Slagsvold, H.H.; Iversen, T.G.; Waelchli, S.; Sandvig, K.
Transport of ricin from endosomes to the Golgi apparatus is regulated by Rab6A and Rab6A
Traffic
7
663-672
2006
Ricinus communis
Carra, J.H.; Wannemacher, R.W.; Tammariello, R.F.; Lindsey, C.Y.; Dinterman, R.E.; Schokman, R.D.; Smith, L.A.
Improved formulation of a recombinant ricin A-chain vaccine increases its stability and effective antigenicity
Vaccine
25
4149-4158
2007
Ricinus communis
Choi, N.W.; Estes, M.K.; Langridge, W.H.
Ricin toxin B subunit enhancement of rotavirus NSP4 immunogenicity in mice
Viral Immunol.
19
54-63
2006
Ricinus communis
Li, X.P.; Chiou, J.C.; Remacha, M.; Ballesta, J.P.; Tumer, N.E.
A Two-Step Binding Model Proposed for the Electrostatic Interactions of Ricin A Chain with Ribosomes
Biochemistry
48
3853-3863
2009
Ricinus communis (P02879)
Chiou, J.C.; Li, X.P.; Remacha, M.; Ballesta, J.P.; Tumer, N.E.
The ribosomal stalk is required for ribosome binding, depurination of the rRNA and cytotoxicity of ricin A chain in Saccharomyces cerevisiae
Mol. Microbiol.
70
1441-1452
2008
Ricinus communis
Keener, W.; Rivera, V.R.; Cho, C.Y.; Hale, M.L.; Garber, E.A.E; Poli, M.A.
Identifitcation of the RNA N-glycosidase activity of ricin in castor bean extracts by an electrochemiluminescence-based assay
Anal. Biochem.
378
87-89
2008
Abrus precatorius, Ricinus communis
Brinkworth, C.S.; Pigott, E.J.; Bourne, D.J.
Detection of intact ricin in crude and purified extracts from castor beans using matrix-assisted laser desorption ionization mass spectrometry
Anal. Chem.
81
1529-1535
2009
Ricinus communis
Zheng, J.; Cui, S.; Teel, L.D.; Zhao, S.; Singh, R.; OBrien, A.D.; Meng, J.
Identification and characterization of Shiga toxin type 2 variants in Escherichia coli isolates from animals, food, and humans
Appl. Environ. Microbiol.
74
5645-5652
2008
Escherichia coli (Q8KTU8), Escherichia coli
Quinones, B.; Massey, S.; Friedman, M.; Swimley, M.S.; Teter, K.
Novel cell-based method to detect Shiga toxin 2 from Escherichia coli O157:H7 and inhibitors of toxin activity
Appl. Environ. Microbiol.
75
1410-1416
2009
Escherichia coli
Wong, J.H.; Wang, H.X.; Ng, T.B.
Marmorin, a new ribosome inactivating protein with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from the mushroom Hypsizigus marmoreus
Appl. Microbiol. Biotechnol.
81
669-674
2008
Hypsizygus marmoreus
Bai, Y.; Monzingo, A.F.; Robertus, J.D.
The X-ray structure of ricin A chain with a novel inhibitor
Arch. Biochem. Biophys.
483
23-28
2009
Ricinus communis (P02879)
Baldwin, A.E.; Khan, M.A.; Tumer, N.E.; Goss, D.J.; Friedland, D.E.
Characterization of pokeweed antiviral protein binding to mRNA cap analogs: competition with nucleotides and enhancement by translation initiation factor iso4G
Biochim. Biophys. Acta
1789
109-116
2009
Phytolacca americana
Di Maro, A.; Chambery, A.; Carafa, V.; Costantini, S.; Colonna, G.; Parente, A.
Structural characterization and comparative modeling of PD-Ls 1-3, type 1 ribosome-inactivating proteins from summer leaves of Phytolacca dioica L
Biochimie
91
352-363
2009
Phytolacca dioica (P84853), Phytolacca dioica (P84854), Phytolacca dioica
Waelchli, S.; Aasheim, H.C.; Skanland, S.S.; Spilsberg, B.; Torgersen, M.L.; Rosendal, K.R.; Sandvig, K.
Characterization of clathrin and Syk interaction upon Shiga toxin binding
Cell. Signal.
21
1161-1168
2009
Escherichia coli
Shimizu, T.; Ohta, Y.; Noda, M.
Shiga toxin 2 is specifically released from bacterial cells by two different mechanisms
Infect. Immun.
77
2813-2823
2009
Escherichia coli
Sikriwal, D.; Ghosh, P.; Batra, J.K.
Ribosome inactivating protein saporin induces apoptosis through mitochondrial cascade, independent of translation inhibition
Int. J. Biochem. Cell Biol.
40
2880-2888
2008
Saponaria officinalis
Roday, S.; Sturm, M.B.; Blakaj, D.; Schramm, V.L.
Detection of an abasic site in RNA with stem-loop DNA beacons: application to an activity assay for Ricin Toxin A-Chain
J. Biochem. Biophys. Methods
70
945-953
2008
Ricinus communis
Mayerhofer, P.U.; Cook, J.P.; Wahlman, J.; Pinheiro, T.T.; Moore, K.A.; Lord, J.M.; Johnson, A.E.; Roberts, L.M.
Ricin A chain insertion into endoplasmic reticulum membranes is triggered by a temperature increase to 37 {degrees}C
J. Biol. Chem.
284
10232-10242
2009
Ricinus communis
Choudhary, N.; Kapoor, H.C.; Lodha, M.L.
Cloning and expression of antiviral/ribosome-inactivating protein from Bougainvillea x buttiana
J. Biosci.
33
91-101
2008
Bougainvillea x buttiana (Q4U473), Bougainvillea x buttiana
Bertholdo-Vargas, L.R.; Martins, J.N.; Bordin, D.; Salvador, M.; Schafer, A.E.; Barros, N.M.; Barbieri, L.; Stirpe, F.; Carlini, C.R.
Type 1 ribosome-inactivating proteins - entomotoxic, oxidative and genotoxic action on Anticarsia gemmatalis (Huebner) and Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae)
J. Insect Physiol.
55
51-58
2009
Suregada multiflora, Momordica charantia, Phytolacca americana, Saponaria officinalis, Silene chalcedonica
Too, P.H.; Ma, M.K.; Mak, A.N.; Wong, Y.T.; Tung, C.K.; Zhu, G.; Au, S.W.; Wong, K.B.; Shaw, P.C.
The C-terminal fragment of the ribosomal P protein complexed to trichosanthin reveals the interaction between the ribosome-inactivating protein and the ribosome
Nucleic Acids Res.
37
602-610
2009
Trichosanthes kirilowii (P09989)
Nagasawa, Y.; Fujii, K.; Yoshikawa, T.; Kobayashi, Y.; Kondo, T.
Pokeweed antiviral protein region Gly209-Lys225 is critical for RNA N-glycosidase activity of the prokaryotic ribosome
Phytochemistry
69
1653-1660
2008
Phytolacca americana, Trichosanthes kirilowii (P24478)
Shahidi-Noghabi, S.; Van Damme, E.J.; Smagghe, G.
Carbohydrate-binding activity of the type-2 ribosome-inactivating protein SNA-I from elderberry (Sambucus nigra) is a determining factor for its insecticidal activity
Phytochemistry
69
2972-2978
2008
Sambucus nigra
Guenhan, E.; Swe, M.; Palazoglu, M.; Voss, J.C.; Chalupa, L.M.
Expression and purification of cysteine introduced recombinant saporin
Protein Expr. Purif.
58
203-209
2008
Saponaria officinalis
Li, M.; Chen, Y.; Liu, Z.; Shen, F.; Bian, X.; Meng, Y.
Anti-tumor activity and immunological modification of ribosome-inactivating protein (RIP) from Momordica charantia by covalent attachment of polyethylene glycol
Acta Biochim. Biophys. Sin. (Shanghai)
41
792-799
2009
Momordica charantia
Tosi, G.; Fermani, S.; Falini, G.; Polito, L.; Bortolotti, M.; Bolognesi, A.
Crystallization and preliminary X-ray diffraction data analysis of stenodactylin, a highly toxic type 2 ribosome-inactivating protein from Adenia stenodactyla
Acta Crystallogr. Sect. F
66
51-53
2010
Adenia stenodactyla
Melchior, W.B.; Tolleson, W.H.
A functional quantitative polymerase chain reaction assay for ricin, Shiga toxin, and related ribosome-inactivating proteins
Anal. Biochem.
396
204-211
2010
Ricinus communis, Escherichia coli
Sturm, M.B.; Schramm, V.L.
Detecting ricin: sensitive luminescent assay for ricin A-chain ribosome depurination kinetics
Anal. Chem.
81
2847-2853
2009
Ricinus communis
Zhang, Y.; Laing, C.; Zhang, Z.; Hallewell, J.; You, C.; Ziebell, K.; Johnson, R.P.; Kropinski, A.M.; Thomas, J.E.; Karmali, M.; Gannon, V.P.
Lineage and host source are both correlated with levels of Shiga toxin 2 production by Escherichia coli O157:H7 strains
Appl. Environ. Microbiol.
76
474-482
2010
Escherichia coli O157:H7 (B6UJ22), Escherichia coli O157:H7 (B6UJ28), Escherichia coli O157:H7
Sturm, M.B.; Tyler, P.C.; Evans, G.B.; Schramm, V.L.
Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein
Biochemistry
48
9941-9948
2009
Saponaria officinalis
Jeong, K.; Chapman-Bonofiglio, S.; Singh, P.; Lee, J.; Tzipori, S.; Sheoran, A.
In vitro and in vivo protective efficacies of antibodies that neutralize the RNA N-glycosidase activity of Shiga toxin 2
BMC Immunol.
11
16-24
2010
Escherichia coli
Weng, A.; Bachran, C.; Fuchs, H.; Krause, E.; Stephanowitz, H.; Melzig, M.F.
Enhancement of saporin cytotoxicity by Gypsophila saponins - more than stimulation of endocytosis
Chem. Biol. Interact.
181
424-429
2009
Saponaria officinalis
Landoni, V.I.; de Campos-Nebel, M.; Schierloh, P.; Calatayud, C.; Fernandez, G.C.; Ramos, M.V.; Rearte, B.; Palermo, M.S.; Isturiz, M.A.
Shiga toxin 1-induced inflammatory response in lipopolysaccharide-sensitized astrocytes is mediated by endogenous tumor necrosis factor alpha
Infect. Immun.
78
1193-1201
2010
Escherichia coli
Tan, Q.; Dong, D.; Yin, X.; Sun, J.; Ren, H.; Li, R.
Comparative analysis of depurination catalyzed by ricin A-chain on synthetic 32mer and 25mer oligoribonucleotides mimicking the sarcin/ricin domain of the rat 28S rRNA and E. coli 23S rRNA
J. Biotechnol.
139
156-162
2009
Ricinus communis
Yang, Y.; Mak, A.N.; Shaw, P.C.; Sze, K.H.
Solution structure of an active mutant of maize ribosome-inactivating protein (MOD) and its interaction with the ribosomal stalk protein P2
J. Mol. Biol.
395
897-907
2010
Zea mays
Reyes, A.G.; Geukens, N.; Gutschoven, P.; De Graeve, S.; De Mot, R.; Mejia Alvarez, A.; Anne, J.
Streptomyces coelicolor genome encodes a type I ribosome-inactivating protein
Microbiology
156
3021-3030
2010
Streptomyces coelicolor
Severino, V.; Chambery, A.; Di Maro, A.; Marasco, D.; Ruggiero, A.; Berisio, R.; Giansanti, F.; Ippoliti, R.; Parente, A.
The role of the glycan moiety on the structure-function relationships of PD-L1, type 1 ribosome-inactivating protein from P. dioica leaves
Mol. Biosyst.
6
570-579
2010
Phytolacca dioica (P84853), Phytolacca dioica
Kawade, K.; Masuda, K.
Transcriptional control of two ribosome-inactivating protein genes expressed in spinach (Spinacia oleracea) embryos
Plant Physiol. Biochem.
47
327-334
2009
Spinacia oleracea (Q8VWY2), Spinacia oleracea
Ho, M.C.; Sturm, M.B.; Almo, S.C.; Schramm, V.L.
Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins
Proc. Natl. Acad. Sci. USA
106
20276-20281
2009
Ricinus communis (P02879), Saponaria officinalis (Q2QEH4)
Shu, S.H.; Xie, G.Z.; Guo, X.L.; Wang, M.
Purification and characterization of a novel ribosome-inactivating protein from seeds of Trichosanthes kirilowii Maxim
Protein Expr. Purif.
67
120-125
2009
Trichosanthes kirilowii
Leshin, J.; Danielsen, M.; Credle, J.J.; Weeks, A.; O'Connell, K.P.; Dretchen, K.
Characterization of ricin toxin family members from Ricinus communis
Toxicon
55
658-661
2010
Ricinus communis
Wahome, P.G.; Bai, Y.; Neal, L.M.; Robertus, J.D.; Mantis, N.J.
Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen
Toxicon
56
313-323
2010
Ricinus communis (P02879)
Shahidi-Noghabi, S.; Van Damme, E.J.; De Vos, W.H.; Smagghe, G.
Internalization of Sambucus nigra agglutinins I and II in insect midgut CF-203 cells
Arch. Insect Biochem. Physiol.
76
211-222
2011
Sambucus nigra
Arfilli, V.; Carnicelli, D.; Rocchi, L.; Ricci, F.; Pagliaro, P.; Tazzari, P.L.; Brigotti, M.
Shiga toxin 1 and ricin A chain bind to human polymorphonuclear leucocytes through a common receptor
Biochem. J.
432
173-180
2010
Ricinus communis, Suregada multiflora, Saponaria officinalis
Horrix, C.; Raviv, Z.; Flescher, E.; Voss, C.; Berger, M.
Plant ribosome-inactivating proteins type II induce the unfolded protein response in human cancer cells
Cell. Mol. Life Sci.
68
1269-1281
2011
Ricinus communis, Ximenia americana, Adenia volkensii
Giansanti, F.; Di Leandro, L.; Koutris, I.; Cialfi, A.; Benedetti, E.; Laurenti, G.; Pitari, G.; Ippoliti, R.
Ricin and saporin: Plant enzymes for the research and the clinics
Curr. Chem. Biol.
4
99-107
2010
Ricinus communis, Saponaria officinalis
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Baskin, D.G.; Kim, F.; Gelling, R.W.; Russell, B.J.; Schwartz, M.W.; Morton, G.J.; Simhan, H.N.; Moralejo, D.H.; Blevins, J.E.
A new oxytocin-saporin cytotoxin for lesioning oxytocin-receptive neurons in the rat hindbrain
Endocrinology
151
4207-4213
2010
Saponaria officinalis
Pruet, J.M.; Jasheway, K.R.; Manzano, L.A.; Bai, Y.; Anslyn, E.V.; Robertus, J.D.
7-Substituted pterins provide a new direction for ricin A chain inhibitors
Eur. J. Med. Chem.
46
3608-3615
2011
Ricinus communis
Jandhyala, D.; Rogers, T.; Kane, A.; Paton, A.; Paton, J.; Thorpe, C.
Shiga toxin 2 and flagellin from Shiga-toxigenic Escherichia coli superinduce interleukin-8 through synergistic effects on host stress-activated protein kinase activation
Infect. Immun.
78
2984-2994
2010
Escherichia coli, Escherichia coli 98NK2 (O113:H21)
Dai, J.; Zhao, L.; Yang, H.; Guo, H.; Fan, K.; Wang, H.; Qian, W.; Zhang, D.; Li, B.; Wang, H.; Guo, Y.
Identification of a novel functional domain of ricin responsible for its potent toxicity
J. Biol. Chem.
286
12166-12171
2011
Ricinus communis (P02879)
Rasooly, R.; Do, P.; Levin, C.; Friedman, M.
Inhibition of Shiga Toxin 2 (Stx2) in apple juices and its resistance to pasteurization
J. Food Sci.
75
M296-M301
2010
Escherichia coli
Trujillo, C.; Taylor-Parker, J.; Harrison, R.; Murphy, J.R.
Essential lysine residues within transmembrane helix 1 of diphtheria toxin facilitate COPI binding and catalytic domain entry
Mol. Microbiol.
76
1010-1019
2010
Corynebacterium diphtheriae
Chhikara, S.; Chaudhury, D.; Dhankher, O.; Jaiwal, P.
Combined expression of a barley class II chitinase and type I ribosome inactivating protein in transgenic Brassica juncea provides protection against Alternaria brassicae
Plant Cell Tissue Organ Cult.
108
83-89
2012
Hordeum vulgare (P04399)
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Marshall, R.; DAvila, F.; Di Cola, A.; Traini, R.; Spano, L.; Fabbrini, M.; Ceriotti, A.
Signal peptide-regulated toxicity of a plant ribosome-inactivating protein during cell stress
Plant J.
65
218-229
2011
Saponaria officinalis
Fratelli, F.; Abrahao-Neto, J.; Caricati, A.T.; Borges, M.M.; Guidolin, R.; Caricati, C.P.
An alternative method for purifying and detoxifying diphtheria toxin
Toxicon
57
1093-1100
2011
Corynebacterium diphtheriae, Corynebacterium diphtheriae PW-8
Di, R.; Kyu, E.; Shete, V.; Saidasan, H.; Kahn, P.C.; Tumer, N.E.
Identification of amino acids critical for the cytotoxicity of Shiga toxin 1 and 2 in Saccharomyces cerevisiae
Toxicon
57
525-539
2011
Escherichia coli
Murphy, J.R.
Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process
Toxins
3
294-308
2011
Corynebacterium diphtheriae
Raimo, G.; Arcucci, A.; Barbieri, L.; Valbonesi, P.; Masullo, M.; Stirpe, F.; Bocchini, V.
The effect of ribosome-inactivating proteins on the ribosome from the hyperthermophilic archaeon Sulfolobus solfataricus
Biochem. Mol. Biol. Int.
44
665-672
1998
Saccharolobus solfataricus
Kaur, I.; Yadav, S.; Hariprasad, G.; Gupta, R.; Srinivasan, A.; Batra, J.; Puri, M.
Balsamin, a novel ribosome-inactivating protein from the seeds of Balsam apple Momordica balsamina
Amino Acids
43
973-981
2012
Momordica balsamina
Quiros, P.; Martinez-Castillo, A.; Muniesa, M.
Improving detection of Shiga toxin-producing Escherichia coli by molecular methods by reducing the interference of free Shiga toxin-encoding bacteriophages
Appl. Environ. Microbiol.
81
415-421
2015
Escherichia coli, Escherichia coli C600
Wang, S.; Zhang, Y.; Liu, H.; He, Y.; Yan, J.; Wu, Z.; Ding, Y.
Molecular cloning and functional analysis of a recombinant ribosome-inactivating protein (alpha-momorcharin) from Momordica charantia
Appl. Microbiol. Biotechnol.
96
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2012
Momordica charantia (P16094), Momordica charantia
Kushwaha, G.S.; Pandey, N.; Sinha, M.; Singh, S.B.; Kaur, P.; Sharma, S.; Singh, T.P.
Crystal structures of a type-1 ribosome inactivating protein from Momordica balsamina in the bound and unbound states
Biochim. Biophys. Acta
1824
679-691
2012
Momordica balsamina (D9J2T9), Momordica balsamina
Au, K.Y.; Wang, R.R.; Wong, Y.T.; Wong, K.B.; Zheng, Y.T.; Shaw, P.C.
Engineering a switch-on peptide to ricin A chain for increasing its specificity towards HIV-infected cells
Biochim. Biophys. Acta
1840
958-963
2014
Ricinus communis
Molla, A.R.; Mandal, D.K.
Trifluoroethanol-induced conformational change of tetrameric and monomeric soybean agglutinin: role of structural organization and implication for protein folding and stability
Biochimie
95
204-214
2013
Glycine max
Adwan, H.; Bayer, H.; Pervaiz, A.; Sagini, M.; Berger, M.R.
Riproximin is a recently discovered type II ribosome inactivating protein with potential for treating cancer
Biotechnol. Adv.
32
1077-1090
2014
Ximenia americana (Q2PA54), Ximenia americana
O'Hara, J.M.; Brey, R.N.; Mantis, N.J.
Comparative efficacy of two leading candidate ricin toxin a subunit vaccines in mice
Clin. Vaccine Immunol.
20
789-794
2013
Ricinus communis
May, K.L.; Li, X.P.; Martinez-Azorin, F.; Ballesta, J.P.; Grela, P.; Tchorzewski, M.; Tumer, N.E.
The P1/P2 proteins of the human ribosomal stalk are required for ribosome binding and depurination by ricin in human cells
FEBS J.
279
3925-3936
2012
Ricinus communis
Harris, S.M.; Yue, W.F.; Olsen, S.A.; Hu, J.; Means, W.J.; McCormick, R.J.; Du, M.; Zhu, M.J.
Salt at concentrations relevant to meat processing enhances Shiga toxin 2 production in Escherichia coli O157:H7
Int. J. Food Microbiol.
159
186-192
2012
Escherichia coli
Rasooly, R.; He, X.; Friedman, M.
Milk inhibits the biological activity of ricin
J. Biol. Chem.
287
27924-27929
2012
Ricinus communis (P02879), Ricinus communis
Bayer, H.; Essig, K.; Stanzel, S.; Frank, M.; Gildersleeve, J.C.; Berger, M.R.; Voss, C.
Evaluation of riproximin binding properties reveals a novel mechanism for cellular targeting
J. Biol. Chem.
287
35873-35886
2012
Ximenia americana
Lo, N.C.; Turner, N.A.; Cruz, M.A.; Moake, J.
Interaction of Shiga toxin with the A-domains and multimers of von Willebrand Factor
J. Biol. Chem.
288
33118-33123
2013
Escherichia coli
Kurnikov, I.V.; Kyrychenko, A.; Flores-Canales, J.C.; Rodnin, M.V.; Simakov, N.; Vargas-Uribe, M.; Posokhov, Y.O.; Kurnikova, M.; Ladokhin, A.S.
pH-triggered conformational switching of the diphtheria toxin T-domain: the roles of N-terminal histidines
J. Mol. Biol.
425
2752-2764
2013
Corynephage beta (P00588)
Rudolph, M.J.; Vance, D.J.; Cheung, J.; Franklin, M.C.; Burshteyn, F.; Cassidy, M.S.; Gary, E.N.; Herrera, C.; Shoemaker, C.B.; Mantis, N.J.
Crystal structures of ricin toxins enzymatic subunit (RTA) in complex with neutralizing and non-neutralizing single-chain antibodies
J. Mol. Biol.
426
3057-3068
2014
Ricinus communis (P02879)
Lee, K.M.; Yusa, K.; Chu, L.O.; Yu, C.W.; Oono, M.; Miyoshi, T.; Ito, K.; Shaw, P.C.; Wong, K.B.; Uchiumi, T.
Solution structure of human P1?P2 heterodimer provides insights into the role of eukaryotic stalk in recruiting the ribosome-inactivating protein trichosanthin to the ribosome
Nucleic Acids Res.
41
8776-8787
2013
Trichosanthes kirilowii
Wong, Y.T.; Ng, Y.M.; Mak, A.N.; Sze, K.H.; Wong, K.B.; Shaw, P.C.
Maize ribosome-inactivating protein uses Lys158-lys161 to interact with ribosomal protein P2 and the strength of interaction is correlated to the biological activities
PLoS ONE
7
e49608
2012
Zea mays
Wang, S.; Zheng, Y.; Yan, J.; Zhu, Z.; Wu, Z.; Ding, Y.
Alpha-momorcharin: a ribosome-inactivating protein from Momordica charantia, possessing DNA cleavage properties
Protein Pept. Lett.
20
1257-1263
2013
Momordica charantia (P16094), Momordica charantia
Kushwaha, G.S.; Yamini, S.; Kumar, M.; Sinha, M.; Kaur, P.; Sharma, S.; Singh, T.P.
First structural evidence of sequestration of mRNA cap structures by type 1 ribosome inactivating protein from Momordica balsamina
Proteins
81
896-905
2013
Momordica balsamina (D9J2T9), Momordica balsamina
Stirpe, F.
Ribosome-inactivating proteins: from toxins to useful proteins
Toxicon
67
12-16
2013
Suregada multiflora, Hordeum vulgare, Phytolacca americana, Bougainvillea spectabilis, Trichosanthes kirilowii (Q8W4U4)
Schieltz, D.M.; McWilliams, L.G.; Kuklenyik, Z.; Prezioso, S.M.; Carter, A.J.; Williamson, Y.M.; McGrath, S.C.; Morse, S.A.; Barr, J.R.
Quantification of ricin, RCA and comparison of enzymatic activity in 18 Ricinus communis cultivars by isotope dilution mass spectrometry
Toxicon
95
72-83
2015
Ricinus communis
Barbier, J.; Bouclier, C.; Johannes, L.; Gillet, D.
Inhibitors of the cellular trafficking of ricin
Toxins
4
15-27
2012
Ricinus communis
Liu, W.Y.
Research on ribosome-inactivating proteins from angiospermae to gymnospermae and cryptogamia
Am. J. Transl. Res.
9
5719-5742
2017
Saccharina japonica, Platycladus orientalis, Trichosanthes kirilowii, Cinnamomum camphora (Q94BW3), Cinnamomum camphora
Wu, Y.; Mao, Y.; Jin, S.; Hou, J.; Du, H.; Yang, M.; Wu, L.
Identification, characterization and structure analysis of a type I ribosome-inactivating protein from Sapium sebiferum (Euphorbiaceae)
Biochem. Biophys. Res. Commun.
463
557-562
2015
Triadica sebifera
Ajji, P.K.; Sonkar, S.P.; Walder, K.; Puri, M.
Purification and functional characterization of recombinant balsamin, a ribosome-inactivating protein from Momordica balsamina
Int. J. Biol. Macromol.
114
226-234
2018
Momordica balsamina
Weng, A.
A novel adenine-releasing assay for ribosome-inactivating proteins
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
1072
300-304
2018
Saponaria officinalis, Dianthus caryophyllus (P24476)
Citores, L.; Iglesias, R.; Gay, C.; Ferreras, J.M.
Antifungal activity of the ribosome-inactivating protein BE27 from sugar beet (Beta vulgaris L.) against the green mould Penicillium digitatum
Mol. Plant Pathol.
17
261-271
2016
Beta vulgaris subsp. vulgaris (Q5QHN9), Beta vulgaris subsp. vulgaris
Gholizadeh, A.
Purification of a ribosome-inactivating protein with antioxidation and root developer potencies from Celosia plumosa
Physiol. Mol. Biol. Plants
25
243-251
2019
Celosia argentea var. plumosa
Ballinger, M.; Perlman, S.
Generality of toxins in defensive symbiosis Ribosome-inactivating proteins and defense against parasitic wasps in Drosophila
PLoS Pathog.
13
e1006431
2017
Spiroplasma poulsonii (A0A3S0SCQ6), Spiroplasma poulsonii (A0A3S0SXV4), Spiroplasma poulsonii (A0A433EMQ2)
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