Information on EC 3.2.2.10 - pyrimidine-5'-nucleotide nucleosidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
3.2.2.10
-
RECOMMENDED NAME
GeneOntology No.
pyrimidine-5'-nucleotide nucleosidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a pyrimidine 5'-nucleotide + H2O = D-ribose 5-phosphate + a pyrimidine base
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of N-glycosyl bond
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
arginomycin biosynthesis
-
-
blasticidin S biosynthesis
-
-
Pyrimidine metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase
Also acts on dUMP, dTMP and dCMP.
CAS REGISTRY NUMBER
COMMENTARY hide
9023-31-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
AKU 0101
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain IFO 3729
-
-
Manually annotated by BRENDA team
strain IFO 3729
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5'-CMP + H2O
cytosine + ribose 5-phosphate
show the reaction diagram
5'-deoxy CMP + H2O
cytosine + deoxyribose 5-phosphate
show the reaction diagram
5'-deoxy TMP + H2O
thymine + deoxyribose 5-phosphate
show the reaction diagram
5'-deoxy UMP + H2O
uracil + deoxyribose 5-phosphate
show the reaction diagram
5'-UMP + H2O
uracil + ribose 5-phosphate
show the reaction diagram
pyrimidine 5'-nucleotides + H2O
?
show the reaction diagram
-
-
-
-
?
ribosylthymine + H2O
?
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
pyrimidine 5'-nucleotides + H2O
?
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
p-chloromercuribenzoate
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6.95
5'-UMP
-
-
0.2
ribosylthymine
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7
-
pyrimidine nucleotides
7.5
-
ribosylthymine
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
from fetal blood
Manually annotated by BRENDA team
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5 - 8.8
-
-
137031
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-4°C, 2 months
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE