Reference on EC 3.2.1.76 - L-iduronidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Matalon, R.; Cifonelli, J.A.; Dorfmann, A.
L-Iduronidase in cultured human fibroblasts and liver
Biochem. Biophys. Res. Commun.
42
340-345
1971
Homo sapiens
Weissmann, B.; Santiago, R.
alpha-L-Iduronidase in lysosomal extracts
Biochem. Biophys. Res. Commun.
46
1430-1433
1972
Rattus norvegicus
Hall, C.W.; Neufeld, E.F.
alpha-L-iduronidase activity in cultured skin fibroblasts and amniotic fluid cells
Arch. Biochem. Biophys.
158
817-821
1993
Homo sapiens
Shapiro, L.J.; Hall, C.W.; Leder, I.G.; Neufeld, E.F.
The relationship of alpha-L-iduronidase and hurler corrective faktor
Arch. Biochem. Biophys.
172
156-161
1976
Homo sapiens
Rome, L.H.; Garvin, A.J.; Neufeld, E.F.
Human kidney alpha-L-iduronidase: purification and characterization
Arch. Biochem. Biophys.
189
344-353
1978
Homo sapiens
Clements, P.R.; Brooks, D.A.; McCourt, P.A.G.; Hopwood, J.J.
Immunopurification and characterization of human alpha-L-iduronidase with the use of monoclonal antibodies
Biochem. J.
259
199-208
1989
Homo sapiens
Ohshita, T.; Sakuda, H.; Nakasone, S.; Iwamasa, T.
Purification, characterization and localization of pig liver alpha-L-iduronidase
Eur. J. Biochem.
179
201-207
1989
Sus scrofa
di Bello, I.C.; Dorling, P.; Fellows, L.; Winchester, B.
Specifc inhibition of human beta-D-glucuronidase and alpha-L-iduronidase by a trihydroxy pipecolic acid of plant origin
FEBS Lett.
176
61-64
1984
Homo sapiens
Myerowitz R.; Neufeld, E.F.
Maturation of alpha-L-iduronidase in cultured human fibroblasts
J. Biol. Chem.
256
3044-3048
1981
Homo sapiens
Clements, P.R.; Brooks, D.A.; Saccone, G.T.P; Hopwood, J.J.
Human alpha-L-iduronidase. 1. purification, monoclonal antibody production, native and subunit molecular mass
Eur. J. Biochem.
152
21-28
1985
Homo sapiens
Clements, P.R.; Muller, V.; Hopwood, J.J.
Human alpha-L-iduronidase. 2. catalytic properties
Eur. J. Biochem.
152
29-34
1985
Homo sapiens
Schuchmann, E.H.; Astrin, K.H.; Aula, P.; Desnick, R.J.
Regional assignment of the structural gene for human alpha-L-iduronidase
Proc. Natl. Acad. Sci. USA
81
1169-1173
1984
Homo sapiens
Schuchmann, E.H.; Guzmann, N.A.; Desnick, R.J.
Human alpha-L-iduronidase. I. Purification and properties of the high uptake (higher molecular weight) and the low uptake (processed) forms
J. Biol. Chem.
259
3132-3140
1984
Homo sapiens
Rome, L.H.
alpha-L-Iduronidase from human kidney
Methods Enzymol.
83
578-583
1982
Homo sapiens
Kosaka, H.; Isemura, M.; Ono, T.; Nishimura, Y.; Kato, K.
Studies on the alpha-L-iduronidase activity of beta-glucuronidase preparations from bovine liver, rat liver, and rat preputial gland
J. Biochem.
88
69-75
1980
Bos taurus, Rattus norvegicus
Freeman, C.; Hopwood, J.J.
Human alpha-L-iduronidase. Catalytic properties and an integrated role in the lysosomal degradation of heparan sulphate
Biochem. J.
282
899-908
1992
Homo sapiens
Stoltzfus, L.J.; Sosa-Pineda, B.; Moskowitz, S.M.; Menon, K.P.; Dlott, B.; Hooper, L.; Teplow, D.B.; Shull, R.M.; Neufeld, E.F.
Cloning and characterization of cDNA encoding canine alpha-L-iduronidase
J. Biol. Chem.
267
6570-6575
1992
Canis sp.
Unger, E.G.; Durrant, J.; Anson, D.S.; Hopwood, J.J.
Recombinant alpha-L-iduronidase: characterization of the purified enzyme and correction of mucopolysaccharidosis type I fibroblasts
Biochem. J.
304
43-49
1994
Homo sapiens
Brooks, D.A.; Harper, G.S.; Gibson, G.J.; Ashton, L.J.; Taylor, J.A.; McCourt, P.A.D.; Freeman, C.; Clements, P.R.; Hoffmann, J.W.; Hopwood, J.J.
Hurler Syndrome: a patient with abnormally high levels of alpha-L-iduronidase
Biochem. Med. Metab. Biol.
47
211-220
1992
Homo sapiens
Kakkis, E.D.; Matynia, A.; Jonas, A.J.; Neufeld, E.F.
Overexpression of the human lysosomal enzyme alpha-L-iduronidase in chinese hamster ovary cells
Protein Expr. Purif.
5
225-232
1994
Homo sapiens
Stewart, K.; Brown, O.A.; Morelli, A.E.; Fairbairn, L.J.; Lashford, L.S.; Cooper, A.; Hatton, C.E.; Dexter, T.M.; Castro, M.G.; Lowenstein, P.R.
Uptake of alpha-(L)-iduronidase produced by retrovirally transduced fibroblasts into neuronal and glial cells in vitro
Gene Ther.
4
63-75
1997
Homo sapiens
Clarke, L.A.; Nasir, J.; Zhang, H.; McDonald, H.; Applegarth, D.A.; Hayden, M.R.; Toone, J.
Murine alpha-L-iduronidase: cDNA isolation and expression
Genomics
24
311-316
1994
Mus musculus
Sakuda, H.; Kusaba, A.; Ohshita, T.; Iwamasw, T.
Tissue and cellular distribution of alpha-L-iduronidase in the pig
J. Histochem. Cytochem.
38
785-792
1990
Sus scrofa
Ruth, L.; Eisenberg, D.; Neufeld, E.F.
alpha-L-Iduronidase forms semi-crystalline spherulites with amyloid-like properties
Acta Crystallogr. Sect. D
56
524-528
2000
Homo sapiens
-
Mandelli, J.; Wajner, A.; Pires, R.F.; Giugliani, R.; Coelho, J.C.
Detection of mucopolysaccharidosis type I heterozygotes based on the biochemical characteristics of leukocyte alpha-L-iduronidase
Arch. Med. Res.
33
20-24
2002
Homo sapiens
Nieman, C.E.; Wong, A.W.; He, S.; Clarke, L.; Hopwood, J.J.; Withers, S.G.
Family 39 alpha-L-iduronidases and beta-D-xylosidases react through similar glycosyl-enzyme intermediates: Identification of the human iduronidase nucleophile
Biochemistry
42
8054-8065
2003
Homo sapiens
Hein, L.K.; Hopwood, J.J.; Clements, P.R.; Brooks, D.A.
The alpha-L-iduronidase mutations R89Q and R89W result in an attenuated mucopolysaccharidosis type I clinical presentation
Biochim. Biophys. Acta
1639
95-103
2003
Homo sapiens
Mandelli, J.; Wajner, A.; Pires, R.; Giugliani, R.; Coelho, J.C.
Effect of CuCl2, NaCl and EDTA on the enzyme alpha-L-iduronidase in the plasma of normal individuals and heterozygotes for MPS I
Clin. Chim. Acta
318
83-89
2002
Homo sapiens
Brooks, D.A.; Fabrega, S.; Hein, L.K.; Parkinson, E.J.; Durand, P.; Yogalingam, G.; Matte, U.; Giugliani, R.; Dasvarma, A.; Eslahpazire, J.; Henrissat, B.; Mornon, J.P.; Hopwood, J.J.; Lehn, P.
Glycosidase active site mutations in human alpha-L-iduronidase
Glycobiology
11
741-750
2001
Homo sapiens
Kloska, A.; Bohdanowicz, J.; Konopa, G.; Tylki-Szym?ska, A.; Jakobkiewicz-Banecka, J.; Czartoryska, B.; Liberek, A.; Wegrzyn, A.; Wegrzyn, G.
Changes in hair morphology of mucopolysaccharidosis I patients treated with recombinant human alpha-L-iduronidase (laronidase, Aldurazyme)
Am. J. Med. Genet. A
139
199-203
2005
Homo sapiens
Yogalingam, G.; Guo, X.H.; Muller, V.J.; Brooks, D.A.; Clements, P.R.; Kakkis, E.D.; Hopwood, J.J.
Identification and molecular characterization of alpha-L-iduronidase mutations present in mucopolysaccharidosis type I patients undergoing enzyme replacement therapy
Hum. Mutat.
24
199-207
2004
Homo sapiens (P35475), Homo sapiens
Prince, W.S.; McCormick, L.M.; Wendt, D.J.; Fitzpatrick, P.A.; Schwartz, K.L.; Aguilera, A.I.; Koppaka, V.; Christianson, T.M.; Vellard, M.C.; Pavloff, N.; Lemontt, J.F.; Qin, M.; Starr, C.M.; Bu, G.; Zankel, T.C.
Lipoprotein receptor binding, cellular uptake, and lysosomal delivery of fusions between the receptor-associated protein (RAP) and alpha-L-iduronidase or acid alpha-glucosidase
J. Biol. Chem.
279
35037-35046
2004
Homo sapiens
Laradi, S.; Tukel, T.; Erazo, M.; Shabbeer, J.; Chkioua, L.; Khedhiri, S.; Ferchichi, S.; Chaabouni, M.; Miled, A.; Desnick, R.J.
Mucopolysaccharidosis I: alpha-L-iduronidase mutations in three tunisian families
J. Inherit. Metab. Dis.
28
1019-1026
2005
Homo sapiens
Hein, L.K.; Bawden, M.; Muller, V.J.; Sillence, D.; Hopwood, J.J.; Brooks, D.A.
alpha-L-Iduronidase premature stop codons and potential read-through in mucopolysaccharidosis type I patients
J. Mol. Biol.
338
453-462
2004
Homo sapiens
Rempel, B.P.; Clarke, L.A.; Withers, S.G.
A homology model for human alpha-L-iduronidase: insights into human disease
Mol. Genet. Metab.
85
28-37
2005
Homo sapiens (P35475), Homo sapiens
Belichenko, P.V.; Dickson, P.I.; Passage, M.; Jungles, S.; Mobley, W.C.; Kakkis, E.D.
Penetration, diffusion, and uptake of recombinant human alpha-L-iduronidase after intraventricular injection into the rat brain
Mol. Genet. Metab.
86
141-149
2005
Homo sapiens
Pabba, J.; Rempel, B.P.; Withers, S.G.; Vasella, A.
Synthesis of glycaro-1,5-lactams and tetrahydrotetrazolopyridine-5-carboxylates: inhibitors of beta-D-glucuronidase and alpha-L-iduronidase
Helv. Chim. Acta
89
635-666
2006
Homo sapiens
-
Di Domenico, C.; Di Napoli, D.; Gonzalez Y. Reyero, E.; Lombardo, A.; Naldini, L.; Di Natale, P.
Limited transgene immune response and long-term expression of human alpha-L-iduronidase in young adult mice with mucopolysaccharidosis type I by liver-directed gene therapy
Hum. Gene Ther.
17
1112-1121
2006
Homo sapiens
Wang, D.; Worsham, D.N.; Pan, D.
Co-expression of MGMT(P140K) and alpha-L-iduronidase in primary hepatocytes from mucopolysaccharidosis type I mice enables efficient selection with metabolic correction
J. Gene Med.
10
249-259
2008
Mus musculus
Chen, F.; Vitry, S.; Hocquemiller, M.; Desmaris, N.; Ausseil, J.; Heard, J.M.
Alpha-L-iduronidase transport in neurites
Mol. Genet. Metab.
87
349-358
2006
Homo sapiens
Chung, S.; Ma, X.; Liu, Y.; Lee, D.; Tittiger, M.; Ponder, K.P.
Effect of neonatal administration of a retroviral vector expressing alpha-L-iduronidase upon lysosomal storage in brain and other organs in mucopolysaccharidosis I mice
Mol. Genet. Metab.
90
181-192
2007
Homo sapiens
Wraith, J.E.; Beck, M.; Lane, R.; van der Ploeg, A.; Shapiro, E.; Xue, Y.; Kakkis, E.D.; Guffon, N.
Enzyme replacement therapy in patients who have mucopolysaccharidosis I and are younger than 5 years: results of a multinational study of recombinant human alpha-L-iduronidase (laronidase)
Pediatrics
120
e37-e46
2007
Homo sapiens
Downing, W.L.; Galpin, J.D.; Clemens, S.; Lauzon, S.M.; Samuels, A.L.; Pidkowich, M.S.; Clarke, L.A.; Kermode, A.R.
Synthesis of enzymatically active human alpha-L-iduronidase in Arabidopsis cgl (complex glycan-deficient) seeds
Plant Biotechnol. J.
4
169-181
2006
Homo sapiens
Kermode, A.R.; Zeng, Y.; Hu, X.; Lauson, S.; Abrams, S.R.; He, X.
Ectopic expression of a conifer Abscisic Acid Insensitive3 transcription factor induces high-level synthesis of recombinant human alpha-L-iduronidase in transgenic tobacco leaves
Plant Mol. Biol.
63
763-776
2007
Homo sapiens (P35475), Homo sapiens
Tsukimura, T.; Tajima, Y.; Kawashima, I.; Fukushige, T.; Kanzaki, T.; Kanekura, T.; Ikekita, M.; Sugawara, K.; Suzuki, T.; Togawa, T.; Sakuraba, H.
Uptake of a recombinant human alpha-L-iduronidase (laronidase) by cultured fibroblasts and osteoblasts
Biol. Pharm. Bull.
31
1691-1695
2008
Homo sapiens
Pastores, G.M.
Laronidase (Aldurazyme): enzyme replacement therapy for mucopolysaccharidosis type I
Expert. Opin. Biol. Ther.
8
1003-1009
2008
Homo sapiens
Sugawara, K.; Saito, S.; Ohno, K.; Okuyama, T.; Sakuraba, H.
Structural study on mutant alpha-L-iduronidases: insight into mucopolysaccharidosis type I
J. Hum. Genet.
53
467-474
2008
Homo sapiens
Wynn, R.F.; Mercer, J.; Page, J.; Carr, T.F.; Jones, S.; Wraith, J.E.
Use of enzyme replacement therapy (Laronidase) before hematopoietic stem cell transplantation for mucopolysaccharidosis I: experience in 18 patients
J. Pediatr.
154
135-139
2009
Homo sapiens
Giugliani, R.; Rojas, V.M.; Martins, A.M.; Valadares, E.R.; Clarke, J.T.; Goes, J.E.; Kakkis, E.D.; Worden, M.A.; Sidman, M.; Cox, G.F.
A dose-optimization trial of laronidase (Aldurazyme) in patients with mucopolysaccharidosis I
Mol. Genet. Metab.
96
13-19
2009
Homo sapiens
Clarke, L.A.; Wraith, J.E.; Beck, M.; Kolodny, E.H.; Pastores, G.M.; Muenzer, J.; Rapoport, D.M.; Berger, K.I.; Sidman, M.; Kakkis, E.D.; Cox, G.F.
Long-term efficacy and safety of laronidase in the treatment of mucopolysaccharidosis I
Pediatrics
123
229-240
2009
Homo sapiens
Kasper, D.C.; Iqbal, F.; Dvorakova, L.; Zeman, J.; Magner, M.; Bodamer, O.; Pollak, A.; Herkner, K.R.; Item, C.B.
Rapid and accurate denaturating high performance liquid chromatography protocol for the detection of alpha-L-iduronidase mutations causing mucopolysaccharidosis type I
Clin. Chim. Acta
411
345-350
2010
Homo sapiens
Boado, R.J.; Hui, E.K.; Lu, J.Z.; Pardridge, W.M.
AGT-181: expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys
J. Biotechnol.
144
135-141
2009
Homo sapiens
Tylki-Szymanska, A.; Marucha, J.; Jurecka, A.; Syczewska, M.; Czartoryska, B.
Efficacy of recombinant human alpha-L-iduronidase (laronidase) on restricted range of motion of upper extremities in mucopolysaccharidosis type I patients
J. Inherit. Metab. Dis.
33
151-157
2010
Homo sapiens
Valayannopoulos, V.; Boddaert, N.; Barbier, V.; Le Merrer, M.; Caillaud, C.; de Lonlay, P.
Cognitive and neuroradiological improvement in three patients with attenuated MPS I treated by laronidase
Mol. Genet. Metab.
100
20-23
2010
Homo sapiens
Tylki-Szymanska, A.; Rozdzynska, A.; Jurecka, A.; Marucha, J.; Czartoryska, B.
Anthropometric data of 14 patients with mucopolysaccharidosis I: retrospective analysis and efficacy of recombinant human alpha-L-iduronidase (laronidase)
Mol. Genet. Metab.
99
10-17
2010
Homo sapiens
Fu, L.; Miao, Y.; Lo, S.; Seto, T.; Sun, S.; Xu, Z.; Clemens, S.; Clarke, L.; Kermode, A.; Jiang, L.
Production and characterization of soluble human lysosomal enzyme ?-iduronidase with high activity from culture media of transgenic tobacco BY-2 cells
Plant Sci.
177
668-675
2009
Homo sapiens
Galpin, J.; Clemens, S.; Kermode, A.
The carboxy-terminal ER-retention motif, SEKDEL, influences the N-linked glycosylation of recombinant human ?-l-iduronidase but has little effect on enzyme activity in seeds of Brassica napus and Nicotiana tabacum
Plant Sci.
178
440-447
2010
Homo sapiens
Sun, L.; Li, C.; Song, X.; Zheng, N.; Zhang, H.; Dong, G.
Three novel alpha-L-iduronidase mutations in 10 unrelated Chinese mucopolysaccharidosis type I families
Genet. Mol. Biol.
34
195-200
2011
Homo sapiens
Vite, C.H.; Wang, P.; Patel, R.T.; Walton, R.M.; Walkley, S.U.; Sellers, R.S.; Ellinwood, N.M.; Cheng, A.S.; White, J.T.; ONeill, C.A.; Haskins, M.
Biodistribution and pharmacodynamics of recombinant human alpha-L-iduronidase (rhIDU) in mucopolysaccharidosis type I-affected cats following multiple intrathecal administrations
Mol. Genet. Metab.
103
268-274
2011
Felis catus, Homo sapiens
Maita, N.; Taniguchi, H.; Sakuraba, H.
Crystallization, X-ray diffraction analysis and SIRAS phasing of human alpha-L-iduronidase
Acta Crystallogr. Sect. F
68
1363-1366
2012
Homo sapiens (P35475)
Lu, F.; Lico, L.; Hung, S.
Synthesis of a fluorogenic substrate for alpha-L-iduronidase
Arkivoc
2013
13-21
2012
Homo sapiens
-
Baldo, G.; Quoos Mayer, F.; Burin, M.; Carrillo-Farga, J.; Matte, U.; Giugliani, R.
Recombinant encapsulated cells overexpressing alpha-L-iduronidase correct enzyme deficiency in human mucopolysaccharidosis type I cells
Cells Tissues Organs
195
323-329
2012
Homo sapiens
Jung, G.; Pabst, M.; Neumann, L.; Berger, A.; Lubec, G.
Characterization of alpha-L-iduronidase (Aldurazyme) and its complexes
J. Proteomics
80
26-33
2013
Homo sapiens
Oussoren, E.; Keulemans, J.; van Diggelen, O.P.; Oemardien, L.F.; Timmermans, R.G.; van der Ploeg, A.T.; Ruijter, G.J.
Residual alpha-L-iduronidase activity in fibroblasts of mild to severe mucopolysaccharidosis type I patients
Mol. Genet. Metab.
109
377-381
2013
Homo sapiens
Ou, L.; Herzog, T.L.; Wilmot, C.M.; Whitley, C.B.
Standardization of alpha-L-iduronidase enzyme assay with Michaelis-Menten kinetics
Mol. Genet. Metab.
111
113-115
2014
Mus musculus, Mus musculus C57BL/6
Maita, N.; Tsukimura, T.; Taniguchi, T.; Saito, S.; Ohno, K.; Taniguchi, H.; Sakuraba, H.
Human alpha-L-iduronidase uses its own N-glycan as a substrate-binding and catalytic module
Proc. Natl. Acad. Sci. USA
110
14628-14633
2013
Homo sapiens
Cheng, W.C.; Lin, C.K.; Li, H.Y.; Chang, Y.C.; Lu, S.J.; Chen, Y.S.; Chang, S.Y.
A combinatorial approach towards the synthesis of non-hydrolysable triazole-iduronic acid hybrid inhibitors of human alpha-L-iduronidase discovery of enzyme stabilizers for the potential treatment of MPSI
Chem. Commun. (Camb.)
54
2647-2650
2018
Homo sapiens (P35475)
Artola, M.; Kuo, C.L.; McMahon, S.A.; Oehler, V.; Hansen, T.; van der Lienden, M.; He, X.; van den Elst, H.; Florea, B.I.; Kermode, A.R.; van der Marel, G.A.; Gloster, T.M.; Codee, J.D.C.; Overkleeft, H.S.; Aerts, J.M.F.G.
New irreversible alpha-L-iduronidase inhibitors and activity-based probes
Chemistry
24
19081-19088
2018
Homo sapiens (P35475), Homo sapiens
Breier, A.C.; Ce, J.; Mezzalira, J.; Daitx, V.V.; Moraes, V.C.; Goldim, M.P.S.; Coelho, J.C.
alpha-L-iduronidase and arylsulfatase B in dried blood spots on filter paper Biochemical parameters and time stability
Clin. Biochem.
50
431-435
2017
Homo sapiens (P35475)
Cardon, F.; Pallisse, R.; Bardor, M.; Caron, A.; Vanier, J.; Ele Ekouna, J.P.; Lerouge, P.; Boitel-Conti, M.; Guillet, M.
Brassica rapa hairy root based expression system leads to the production of highly homogenous and reproducible profiles of recombinant human alpha-L-iduronidase
Plant Biotechnol. J.
17
505-516
2019
Homo sapiens (P35475), Homo sapiens
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