Reference on EC 3.2.1.62 - glycosylceramidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wuthrich, M.; Creemers, J.W.M.; van de Ven, W.J.M.; Sterchi, E.E.
Human lactase-phlorizin hydrolase is not processed by furin, PC1/PC3, PC2, PACE4 and PC5/PC6A of the family of subtilisin-like proprotein processing proteases
Biochim. Biophys. Acta
1311
199-203
1996
Homo sapiens, Sus scrofa, Mus musculus, Vaccinia virus
Day, A.J.; Canada, F.J.; Diaz, J.C.; Kroon, P.A.; Mclauchlan, R.; Faulds, C.B.; Plumb, G.W.; Morgan, M.R.A.; Williamson, G.
Dietary flavonoids and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase
FEBS Lett.
468
166-170
2000
Ovis aries, Ovis aries aries
Jacob, R.; Weiner, J.R.; Stadge, S.; Naim, H.Y.
Additional N-glycosylation and its impact on the folding of intestinal lactase-phlorizin hydrolase
J. Biol. Chem.
275
10630-10637
2000
Homo sapiens
Wuthrich, M.; Sterchi, E.E.
Human lactase-phloizin hydrolase expressed in Cos-1 cells is proteolytically processed by the lysosomal pathway
FEBS Lett.
405
321-327
1997
Homo sapiens
Estrada, G.; Krasinski, S.D.; Montgomery, R.K.; Grand, R.J.; Garcia-Valero, J.; Lopez-Tejero, M.D.
Quantitative analysis of lactase-phlorizin hydrolase expression in the absorptive enterocytes of newborn rat small intestine
J. Cell. Physiol.
167
341-348
1996
BRENDA: Rattus sp.
Textmining: Rattus
Naim, H.Y.
The pro-region of human intestinale lactase-phlorizin hydrolase is enzymatically inactive towards lactose
Biol. Chem. Hoppe-Seyler
376
255-258
1995
Homo sapiens
Naim, H.Y.
Processing and transport of human small intestinal lactase-phlorizin hydrolase (LPH). Role of N-linked oligosaccharide modification
FEBS Lett.
342
302-307
1994
Homo sapiens
Naim, H.Y.; Lentze, M.J.
Impact of O-glycosylation on the function of human intestinal lactase-phlorizin hydrolase. Characterization of glycoforms varying in enzyme activity and localization of O-glycoside addition
J. Biol. Chem.
267
25494-25504
1992
BRENDA: Homo sapiens
Textmining: Helix pomatia
Wacker, H.; Keller, P.; Falchetto, R.; Legler, G.; Semenza, G.
Location of the two catalytic sites in intestinal lactase-phlorizin hydrolase
J. Biol. Chem.
267
18744-18752
1992
Oryctolagus cuniculus
Mantei, N.; Villa, M.; Enzler, T.; Wacker, H.; Boll, W.; James, P.; Hunziker, W.; Semenza, G.
Complete primary structure of human and rabbit lactase-phlorizin hydrolase: implications for biosynthesis, membrane anchoring and evolution of the enzyme
EMBO J.
7
2705-2713
1988
Oryctolagus cuniculus, Homo sapiens
Buller, H.A.; Montgomery, R.K.; Sasak, W.V.; Grand, R.J.
Biosynthesis, glycosylation, and intracellular transport of intestinal lactase-phlorizin hydrolase in rat
J. Biol. Chem.
262
17206-17211
1987
BRENDA: Rattus sp.
Textmining: Rattus, Glycine max
Naim, H.Y.; Sterchi, E.E.; Lentze, M.J.
Biosynthesis and maturation of lactase-phlorizin hydrolase in the human small intestinal epithelial
Biochem. J.
241
427-434
1987
Homo sapiens
Danielsen, E.M.; Skovbjerg, H.; Noren, O.; Sjstrm, H.
Biosynthesis of intestinal microvillar proteins. Intracellular processing of lactase-phlorizin hydrolase
Biochem. Biophys. Res. Commun.
122
82-90
1984
Sus scrofa
Skovbjerg, H.; Danielsen, E.M.; Noren, O.; Sjstrm, H.
Evidence for biosynthesis of lactase-phlorizin hydrolase as a single-chain high-molecular weight precursor
Biochim. Biophys. Acta
798
247-251
1984
Homo sapiens
Skovbjerg, H.; Sjstrm, H.; Noren, O.
Purification and characterization of amphiphilic lactase/phlorizin hydrolase from human small intestine
Eur. J. Biochem.
114
653-661
1981
Homo sapiens
Skovbjerg, H.; Noren, O.; Sjstrm, H.; Danielsen, E.M.; Enevoldsen, B.S.
Further characterization of intestinal lactase/phlorizin hydrolase
Biochim. Biophys. Acta
707
89-97
1982
Homo sapiens, Sus scrofa
Kobayashi, T.; Suzuki, K.
The glycosylceramidase in the murine intestine. Purification and substrate specificity
J. Biol. Chem.
256
7768-7773
1981
BRENDA: Mus musculus
Textmining: Lateolabrax japonicus, Oryctolagus cuniculus
Cousineau, J.; Green, J.R.
Isolation and characterization of the proximal and distal forms of lactase-phlorizin hydrolase from the small intestine of the suckling rat
Biochim. Biophys. Acta
615
147-157
1980
BRENDA: Rattus sp.
Textmining: Rattus
Ramaswamy, S.; Radhakrishnan, A.N.
Lactase-phlorizin hydrolase complex from monkey small intestine. Purification, properties and evidence for two catalytic sites
Biochim. Biophys. Acta
403
446-455
1975
BRENDA: Macaca radiata
Textmining: Platyrrhini
Birkenmeier, E.; Alpers, D.H.
Enzymatic properties of rat lactase-phlorizin hydrolase
Biochim. Biophys. Acta
350
100-112
1974
BRENDA: Rattus sp.
Textmining: Rattus
Leese, H.J.; Semenza, G.
On the identity between the small intestine enzymes phlorizin hydrolase and glycosylceramidase
J. Biol. Chem.
248
8170-8173
1973
Rattus sp.
Hamaswamy, S.; Radhakrishnan, A.N.
Lactase-phlorizin hydrolase complex from monkey small intestine: Stimulation of phlorizin hydrolase activity by organic acids
Biochem. Biophys. Res. Commun.
54
197-204
1973
BRENDA: Macaca radiata
Textmining: Platyrrhini
Kraml, J.; Kolinska, J.; Ellederova, D.; Hirsova, D.
beta-Glucosidase (phlorizin hydrolase) activity of the lactase fraction isolated from the small intestinal mucosa of infant rats, and the relationship between beta-glucosidases and beta-galactosidases
Biochim. Biophys. Acta
258
520-530
1972
Rattus sp.
Malathi, P.; Crane, R.K.
Phlorizin hydrolase: A beta-glucosidase of hamster intestinal brush border membrane
Biochim. Biophys. Acta
173
245-256
1969
Cricetinae
Bueller, H.A.; Kothe, M.J.C.; Goldman, D.A.; Grubman, S.A.; Sasak, W.V.; Matsudaira, P.T.; Montgomery, R.K.; Grand, R.J.
Coordinate expression of lactate-phlorizin hydrolase mRNA and enzyme levels in rat intestine during development
J. Biol. Chem.
265
6978-6953
1990
Rattus
Izu, H.; Izumi, Y.; Kurome, Y.; Sano, M.; Kondo, A.; Kato, I.; Ito, M.
Molecular cloning, expression, and sequence analysis of the endoglycoceramidase II gene from Rhodococcus species strain M-777
J. Biol. Chem.
272
19846-19850
1997
Rhodococcus
Miura, Y.; Arai, T.; Ohtake, A.; Ito, M.; Yamamoto, K.; Yamagata, T.
Requirement for a different hydrophobic moiety and reliable chromogenic substrate for endo-type glycosylceramidases
Glycobiology
9
957-960
1999
Bacteria, Rhodococcus
Day, A.J.; Gee, J.M.; DuPont, M.S.; Johnson, I.T.; Williamson, G.
Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter
Biochem. Pharmacol.
65
1199-1206
2003
Rattus norvegicus
Arribas, J.C.; Herrero, A.G.; Martin-Lomas, M.; Canada, F.J.; He, S.; Withers, S.G.
Differential mechanism-based labeling and unequivocal activity assignment of the two active sites of intestinal lactase/phlorizin hydrolase
Eur. J. Biochem.
267
6996-7005
2000
BRENDA: Ovis aries
Textmining: Mammalia
Mackey, A.D.; Henderson, G.N.; Gregory, J.F., 3rd
Enzymatic hydrolysis of pyridoxine-5'-beta-D-glucoside is catalyzed by intestinal lactase-phlorizin hydrolase
J. Biol. Chem.
277
26858-26864
2002
BRENDA: Rattus norvegicus
Textmining: Rattus
Jacob, R.; Peters, K.; Naim, H.Y.
Prosequence of human lactase-phlorizin hydrolase modulates the folding of mature enzyme
J. Biol. Chem.
277
8217-8225
2002
Homo sapiens
Burrin, D.G.; Stoll, B.; Fan, M.Z.; Dudley, M.A.; Donovan, S.M.; Reeds, P.J.
Oral IGF-I alters the posttranslational processing but not the activity of lactase-phlorizin hydrolase in formula-fed neonatal pigs
J. Nutr.
131
2235-2241
2001
BRENDA: Sus scrofa
Textmining: Suidae
Sesink, A.L.; Arts, I.C.; Faassen-Peters, M.; Hollman, P.C.
Intestinal uptake of quercetin-3-glucoside in rats involves hydrolysis by lactase phlorizin hydrolase
J. Nutr.
133
773-776
2003
Rattus norvegicus
Wilkinson, A.P.; Gee, J.M.; Dupont, M.S.; Needs, P.W.; Mellon, F.A.; Williamson, G.; Johnson, I.T.
Hydrolysis by lactase phlorizin hydrolase is the first step in the uptake of daidzein glucosides by rat small intestine in vitro
Xenobiotica
33
255-264
2003
Rattus norvegicus
Lewinsky, R.H.; Jensen, T.G.; M?ller, J.; Stensballe, A.; Olsen, J.; Troelsen, J.T.
T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro
Hum. Mol. Genet.
14
3945-3953
2005
Homo sapiens
Mizuma, T.; Fuseda, N.; Hayashi, M.
Kinetic characterization of glycosidase activity from disaccharide conjugate to monosaccharide conjugate in Caco-2 cells
J. Pharm. Pharmacol.
57
661-664
2005
Homo sapiens
Tseung, C.W.; McMahon, L.G.; Vazquez, J.; Pohl, J.; Gregory, J.F.
Partial amino acid sequence and mRNA analysis of cytosolic pyridoxine-beta-D-glucoside hydrolase from porcine intestinal mucosa: proposed derivation from the lactase-phlorizin hydrolase gene
Biochem. J.
380
211-218
2004
Homo sapiens, Metazoa, Oryctolagus cuniculus, plant, Sus scrofa
Bodlaj, G.; Stoecher, M.; Hufnagl, P.; Hubmann, R.; Biesenbach, G.; Stekel, H.; Berg, J.
Genotyping of the lactase-phlorizin hydrolase -13910 polymorphism by lightCycler PCR and implications for the diagnosis of lactose intolerance
Clin. Chem.
52
148-151
2006
Homo sapiens
Verhave, M.; Krasinski, S.D.; Christian, S.I.; Van Schaik, S.; Van Den Brink, G.R.; Doting, E.M.; Maas, S.M.; Wolthers, K.C.; Grand, R.J.; Montgomery, R.K.
Regulatory regions in the rat lactase-phlorizin hydrolase gene that control cell-specific expression
J. Pediatr. Gastroenterol. Nutr.
39
275-285
2004
Rattus, Metazoa
Bosse, T.; Piaseckyj, C.M.; Burghard, E.; Fialkovich, J.J.; Rajagopal, S.; Pu, W.T.; Krasinski, S.D.
Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine
Mol. Cell. Biol.
26
9060-9070
2006
Mus sp.
Bosse, T.; Fialkovich, J.J.; Piaseckyj, C.M.; Beuling, E.; Broekman, H.; Grand, R.J.; Montgomery, R.K.; Krasinski, S.D.
Gata4 and Hnf1alpha are partially required for the expression of specific intestinal genes during development
Am. J. Physiol. Gastrointest. Liver Physiol.
292
G1302-G1314
2007
BRENDA: Mus musculus
Textmining: Mus sp.
Beau, I.; Cotte-Laffitte, J.; Geniteau-Legendre, M.; Estes, M.K.; Servin, A.L.
An NSP4-dependant mechanism by which rotavirus impairs lactase enzymatic activity in brush border of human enterocyte-like Caco-2 cells
Cell. Microbiol.
9
2254-2266
2007
BRENDA: Homo sapiens
Textmining: Rotavirus, Macaca mulatta
Caines, M.E.; Vaughan, M.D.; Tarling, C.A.; Hancock, S.M.; Warren, R.A.; Withers, S.G.; Strynadka, N.C.
Structural and mechanistic analyses of endo-glycoceramidase II, a membrane-associated family 5 glycosidase in the Apo and GM3 ganglioside-bound forms
J. Biol. Chem.
282
14300-14308
2007
Rhodococcus sp.
Hayashi, Y.; Okino, N.; Kakuta, Y.; Shikanai, T.; Tani, M.; Narimatsu, H.; Ito, M.
Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase
J. Biol. Chem.
282
30889-30900
2007
BRENDA: Danio rerio, Homo sapiens, Mus musculus, Rattus norvegicus, Tetraodontidae
Textmining: Rattus
He, W.; Ji, Z.Y.; Huang, C.Y.
Molecular cloning of a novel cDNA from Mus muscular BALB/c mice encoding glycosyl hydrolase family 1: a homolog of human lactase-phlorizin hydrolase
Biomed. Environ. Sci.
19
340-345
2006
Homo sapiens, Mus sp., Oryctolagus cuniculus, Rattus, Mus musculus
Bernardes-Silva Carlos Felip, B.C.; Pereira Alexandre , P.A.; de Fatima Alves da Mota Glori, d.F.; Krieger Jose Eduard, K.J.; Laudanna Antonio Atili, L.A.
Lactase persistence/non-persistence variants, C/T_13910 and G/A_22018, as a diagnostic tool for lactose intolerance in IBS patients
Clin. Chim. Acta
386
7-11
2007
Homo sapiens
Piepoli, A.; Schirru, E.; Mastrorilli, A.; Gentile, A.; Cotugno, R.; Quitadamo, M.; Merla, A.; Congia, M.; Usai Satta, P.; Perri, F.
Genotyping of the lactase-phlorizin hydrolase c/t-13910 polymorphism by means of a new rapid denaturing high-performance liquid chromatography-based assay in healthy subjects and colorectal cancer patients
J. Biomol. Screen.
12
733-739
2007
Homo sapiens, Areas
Behrendt, M.; Keiser, M.; Hoch, M.; Naim, H.Y.
Impaired trafficking and subcellular localization of a mutant lactase associated with congenital lactase deficiency
Gastroenterology
136
2295-2303
2009
Homo sapiens
Willing, B.P.; Van Kessel, A.G.
Intestinal microbiota differentially affect brush border enzyme activity and gene expression in the neonatal gnotobiotic pig
J. Anim. Physiol. Anim. Nutr. (Berl.)
93
586-595
2008
Sus scrofa
Delacour, D.; Koch, A.; Ackermann, W.; Eude-Le Parco, I.; Elsaesser, H.P.; Poirier, F.; Jacob, R.
Loss of galectin-3 impairs membrane polarisation of mouse enterocytes in vivo
J. Cell Sci.
121
458-465
2008
Mus sp., Mus musculus
Tanaka, T.; Suzuki, A.; Kuranuki, S.; Mochizuki, K.; Suruga, K.; Takase, S.; Goda, T.
Higher expression of jejunal LPH gene in rats fed the high-carbohydrate/low-fat diet compared with those fed the low-carbohydrate/high-fat diet is associated with in vitro binding of Cdx-2 in nuclear proteins to its promoter regions
Life Sci.
83
122-127
2008
BRENDA: Rattus norvegicus
Textmining: Rattus
Cramm-Behrens, C.I.; Dienst, M.; Jacob, R.
Apical cargo traverses endosomal compartments on the passage to the cell surface
Traffic
9
2206-2220
2008
BRENDA: Homo sapiens
Textmining: Canis lupus familiaris
Behrendt, M.; Polaina, J.; Naim, H.Y.
Structural hierarchy of regulatory elements in the folding and transport of an intestinal multidomain protein
J. Biol. Chem.
285
4143-4152
2010
BRENDA: Homo sapiens
Textmining: Canis lupus familiaris
Koek, W.; van Meurs, J.; van der Eerden, B.; Rivadeneira, F.; Zillikens, M.; Hofman, A.; Obermayer-Pietsch, B.; Lips, P.; Pols, H.; Uitterlinden, A.; van Leeuwen, J.
The T-13910C polymorphism in the lactase phlorizin hydrolase gene is associated with differences in serum calcium levels and calcium intake
J. Bone Miner. Res.
25
1980-1987
2010
Homo sapiens
Rich, J.R.; Cunningham, A.M.; Gilbert, M.; Withers, S.G.
Glycosphingolipid synthesis employing a combination of recombinant glycosyltransferases and an endoglycoceramidase glycosynthase
Chem. Commun. (Camb. )
47
10806-10808
2011
Rhodococcus sp.
Karlsson, H.; Halim, A.; Teneberg, S.
Differentiation of glycosphingolipid-derived glycan structural isomers by liquid chromatography/mass spectrometry
Glycobiology
20
1103-1116
2010
Rhodococcus sp.
Naz, S.; Siddiqi, R.; Dew, T.P.; Williamson, G.
Epigallocatechin-3-gallate inhibits lactase but is alleviated by salivary proline-rich proteins
J. Agric. Food Chem.
59
2734-2738
2011
Rattus norvegicus
Ishibashi, Y.; Ikeda, K.; Sakaguchi, K.; Okino, N.; Taguchi, R.; Ito, M.
Quality control of fungus-specific glucosylceramide in Cryptococcus neoformans by endoglycoceramidase-related protein 1 (EGCrP1)
J. Biol. Chem.
287
368-381
2012
BRENDA: Cryptococcus neoformans (H1AE12), Cryptococcus neoformans, Cryptococcus neoformans H99 (H1AE12)
Textmining: Fungi, Cryptococcus neoformans var. grubii
Watanabe, T.; Ito, T.; Goda, H.M.; Ishibashi, Y.; Miyamoto, T.; Ikeda, K.; Tagucho, R.; Okino, N.; Ito, M.
Sterylglucoside catabolism in Cryptococcus neoformans with endoglycoceramidase-related protein 2 (EGCrP2), the first steryl-beta-glucosidase identified in fungi
J. Biol. Chem.
290
1005-1019
2015
Cryptococcus neoformans, Ikeda
Durand, J.; Biarnes, X.; Watterlot, L.; Bonzom, C.; Borsenberger, V.; Planas, A.; Bozonnet, S.; O'Donohue, M.; Faure, R.
A single point mutation alters the transglycosylation/Hydrolysis partition, significantly enhancing the synthetic capability of an endo-glycoceramidase
ACS Catal.
6
8264-8275
2016
Rhodococcus sp. M-777 (O33853)
-
Ben Bdira, F.; Jiang, J.; Kallemeijn, W.; de Haan, A.; Florea, B.I.; Bleijlevens, B.; Boot, R.; Overkleeft, H.S.; Aerts, J.M.; Ubbink, M.
Hydrophobic interactions contribute to conformational stabilization of endoglycoceramidase II by mechanism-based probes
Biochemistry
55
4823-4835
2016
BRENDA: Rhodococcus sp. M777 (O33853)
Textmining: Rhodococcus sp., Rhodococcus sp. (O33853)
Watanabe, T.; Tani, M.; Ishibashi, Y.; Endo, I.; Okino, N.; Ito, M.
Ergosteryl-beta-glucosidase (Egh1) involved in sterylglucoside catabolism and vacuole formation in Saccharomyces cerevisiae
Glycobiology
25
1079-1089
2015
BRENDA: Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Textmining: Cryptococcus neoformans
Watanabe, T.; Ito, T.; Goda, H.; Ishibashi, Y.; Miyamoto, T.; Ikeda, K.; Taguchi, R.; Okino, N.; Ito, M.
Sterylglucoside catabolism in cryptococcus neoformans with endoglycoceramidase-related protein 2 (EGCrP2), the first steryl-beta-glucosidase identified in fungi
J. Biol. Chem.
290
1005-1019
2015
Cryptococcus neoformans, Cryptococcus neoformans (A0A228BX09), Ikeda
Diekmann, L.; Behrendt, M.; Amiri, M.; Naim, H.Y.
Structural determinants for transport of lactase phlorizin-hydrolase in the early secretory pathway as a multi-domain membrane glycoprotein
Biochim. Biophys. Acta Gen. Subj.
1861
3119-3128
2017
Homo sapiens (P09848)
Keller, P; Zecca, L; Boukamel, R; Zwicker, E; Gloor, S; Semenza, G
Furin, PC1/3, and/or PC6A process rabbit, but not human, pro-lactase-phlorizin hydrolase to the 180-kDa intermediate.
J Biol Chem
270
25722-8
1995
Homo sapiens, Oryctolagus cuniculus
Mesonero, JE; Gloor, SM; Semenza, G
Processing of human intestinal prolactase to an intermediate form by furin or by a furin-like proprotein convertase.
J Biol Chem
273
29430-6
1998
Homo sapiens, Oryctolagus cuniculus
Torp, N; Rossi, M; Troelsen, JT; Olsen, J; Danielsen, EM
Lactase-phlorizin hydrolase and aminopeptidase N are differentially regulated in the small intestine of the pig.
Biochem J
295 ( Pt 1)
177-82
1993
Sus scrofa, Suidae, Metazoa
Hecht, A; Torbey, CF; Korsmo, HA; Olsen, WA
Regulation of sucrase and lactase in developing rats: role of nuclear factors that bind to two gene regulatory elements.
Gastroenterology
112
803-12
1997
Rattus, Metazoa
Lee, MF; Russell, RM; Montgomery, RK; Krasinski, SD
Total intestinal lactase and sucrase activities are reduced in aged rats.
J Nutr
127
1382-7
1997
Areas, Homo sapiens, Metazoa, Rattus
Fukushima, A; Goda, T; Motohashi, Y; Sakuma, K
The specific expression patterns of lactase, sucrase and calbindin-D9k in weaning rats are regulated at the transcriptional level.
J Nutr Sci Vitaminol (Tokyo)
50
265-71
2004
Rattus
Dudley, MA; Hachey, DL; Quaroni, A; Hutchens, TW; Nichols, BL; Rosenberger, J; Perkinson, JS; Cook, G; Reeds, PJ
In vivo sucrase-isomaltase and lactase-phlorizin hydrolase turnover in the fed adult rat.
J Biol Chem
268
13609-16
1993
Rattus, Metazoa
Goda, T; Yasutake, H; Tanaka, T; Takase, S
Lactase-phlorizin hydrolase and sucrase-isomaltase genes are expressed differently along the villus-crypt axis of rat jejunum.
J Nutr
129
1107-13
1999
Rattus
Ramaswamy, S; Radhakrishnan, AN
Lactase and phlorizin hydrolase from rabbit small intestine.
Indian J Biochem Biophys
12
199-203
1975
Oryctolagus cuniculus
Dudley, MA; Shulman, RJ; Reeds, PJ; Rosenberger, JN; Putman, M; Johnston, PK; Perkinson, JS; Nichols, BL
Developmental changes in lactase-phlorizin hydrolase precursor isoforms in the rat.
J Pediatr Gastroenterol Nutr
15
260-9
1992
Rattus, Metazoa, animal
Lottaz, D; Oberholzer, T; Bähler, P; Semenza, G; Sterchi, EE
Maturation of human lactase-phlorizin hydrolase. Proteolytic cleavage of precursor occurs after passage through the Golgi complex.
FEBS Lett
313
270-6
1992
Homo sapiens, insertion sequences
Grünberg, J; Luginbühl, U; Sterchi, EE
Proteolytic processing of human intestinal lactase-phlorizin hydrolase precursor is not a prerequisite for correct sorting in Madin Darby canine kidney (MDCK) cells.
FEBS Lett
314
224-8
1992
Homo sapiens, Canis lupus familiaris
Freund, JN
Do co-translated product(s) of lactase-phlorizin hydrolase accumulate in the rat intestine?
Cell Mol Biol (Noisy-le-grand)
38
713-8
1992
Rattus
Tsuboi, KK; Kwong, LK; Sunshine, P; Castillo, RO
Mechanism of maturational decline of rat intestinal lactase-phlorizin hydrolase.
Biochem J
282 ( Pt 1)
107-13
1992
Rattus
Freund, JN; Gossé, F; Raul, F
Derivatives of plant beta-glucans are hydrolyzed by intestinal lactase-phlorizin hydrolase of mammals.
Enzyme
45
71-4
1991
Mammalia, plant
Boll, W; Wagner, P; Mantei, N
Structure of the chromosomal gene and cDNAs coding for lactase-phlorizin hydrolase in humans with adult-type hypolactasia or persistence of lactase.
Am J Hum Genet
48
889-902
1991
Homo sapiens
Naim, HY; Lacey, SW; Sambrook, JF; Gething, MJ
Expression of a full-length cDNA coding for human intestinal lactase-phlorizin hydrolase reveals an uncleaved, enzymatically active, and transport-competent protein.
J Biol Chem
266
12313-20
1991
Homo sapiens
Duluc, I; Boukamel, R; Mantei, N; Semenza, G; Raul, F; Freund, JN
Sequence of the precursor of intestinal lactase-phlorizin hydrolase from fetal rat.
Gene
103
275-6
1991
Rattus
Büller, HA; Rings, EH; Pajkrt, D; Montgomery, RK; Grand, RJ
Glycosylation of lactase-phlorizin hydrolase in rat small intestine during development.
Gastroenterology
98
667-75
1990
Rattus
Büller, HA; Van Wassenaer, AG; Raghavan, S; Montgomery, RK; Sybicki, MA; Grand, RJ
New insights into lactase and glycosylceramidase activities of rat lactase-phlorizin hydrolase.
Am J Physiol
257
G616-23
1989
Mammalia, Rattus
Castillo, RO; Kwong, LK; Reisenauer, AM; Tsuboi, KK
Human intestinal lactase-phlorizin hydrolase: isolation and preparation of a specific antiserum.
Biochem Biophys Res Commun
164
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Canis lupus familiaris, insertion sequences, Homo sapiens, Sus scrofa
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Homo sapiens, Acetivibrio thermocellus, Escherichia coli, Saccharolobus solfataricus, Terminator, archaebacterium
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Homo sapiens
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Mus musculus, Rattus, Homo sapiens
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Homo sapiens, plant, Rattus
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Homo sapiens
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Homo sapiens
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Sus scrofa
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Homo sapiens, Rattus
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Homo sapiens, Sus scrofa, Suidae
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FASEB J
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Homo sapiens, Metazoa
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The pro sequence of lactase-phlorizin hydrolase is required for the enzyme to reach the plasma membrane. An intramolecular chaperone?
FEBS Lett
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Homo sapiens
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Dimerization of lactase-phlorizin hydrolase occurs in the endoplasmic reticulum, involves the putative membrane spanning domain and is required for an efficient transport of the enzyme to the cell surface.
Eur J Cell Biol
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1996
Homo sapiens
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The apical sorting of lactase-phlorizin hydrolase implicates sorting sequences found in the mature domain.
Eur J Cell Biol
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1997
Canis lupus familiaris
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A possible role of a nuclear factor NF-LPH1 in the regional expression of lactase-phlorizin hydrolase along the small intestine.
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Rattus
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Homo sapiens, vesicular stomatitis virus
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The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1alpha-dependent transcription.
J Biol Chem
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Saccharomyces cerevisiae, Homo sapiens, Mammalia
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Assignment of the locus for congenital lactase deficiency to 2q21, in the vicinity of but separate from the lactase-phlorizin hydrolase gene.
Am J Hum Genet
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1998
Homo sapiens
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Intestinal lactase-phlorizin hydrolase (LPH): the two catalytic sites; the role of the pancreas in pro-LPH maturation.
FEBS Lett
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Homo sapiens
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Canis lupus familiaris
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Interaction between the homeodomain proteins Cdx2 and HNF1alpha mediates expression of the lactase-phlorizin hydrolase gene.
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Sus scrofa, Mus musculus
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Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia.
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Homo sapiens
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Transcriptional regulation of the lactase-phlorizin hydrolase promoter by PDX-1.
Am J Physiol Gastrointest Liver Physiol
287
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Homo sapiens, Mammalia
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Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4.
Am J Physiol Gastrointest Liver Physiol
287
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Mus musculus
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PCR-RFLP genotyping assay for a lactase persistence polymorphism upstream of the lactase-phlorizin hydrolase gene.
Genet Test
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Homo sapiens
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Hepatocyte nuclear factor-1alpha is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo.
Am J Physiol Gastrointest Liver Physiol
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Mus sp., Mus musculus
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Substrate specificity of small-intestinal lactase. Assessment of the role of the substrate hydroxyl groups.
Eur J Biochem
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Mammalia
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Ultrastructural study of intestinal lactase gene expression.
Biol Cell
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Mammalia
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Rattus
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Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element.
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Homo sapiens
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An upstream polymorphism associated with lactase persistence has increased enhancer activity.
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Homo sapiens
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Molecular differentiation of congenital lactase deficiency from adult-type hypolactasia.
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Homo sapiens
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Theodore E. Woodward Award: lactase persistence SNPs in African populations regulate promoter activity in intestinal cell culture.
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Homo sapiens
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Homo sapiens
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Congenital lactose intolerance is triggered by severe mutations on both alleles of the lactase gene.
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Homo sapiens
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Homo sapiens, insertion sequences
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Messenger RNA sorting in enterocytes. Co-localization with encoded proteins.
FEBS Lett
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