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Information on EC 3.2.1.52 - beta-N-acetylhexosaminidase and Organism(s) Felis catus and UniProt Accession P49614

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EC Tree
IUBMB Comments
Acts on N-acetylglucosides and N-acetylgalactosides.
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This record set is specific for:
Felis catus
UNIPROT: P49614
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Word Map
The taxonomic range for the selected organisms is: Felis catus
The enzyme appears in selected viruses and cellular organisms
Synonyms
beta-hexosaminidase, hexosaminidase, n-acetyl-beta-glucosaminidase, o-glcnacase, hex a, n-acetylglucosaminidase, hexosaminidase a, beta-n-acetylhexosaminidase, hex b, beta-hexosaminidase a, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosaminidase
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2-acetamido-2-deoxy-beta-D-glucoside acetamidodeoxyglucohydrolase
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65 kDa epididymal boar protein
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-
-
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beta-acetylaminodeoxyhexosidase
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-
-
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beta-acetylhexosaminidase
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-
-
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beta-acetylhexosaminidinase
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-
-
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beta-D-hexosaminidase
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-
-
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beta-D-N-acetylhexosaminidase
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-
-
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Beta-GlcNAcase
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-
-
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beta-hexosaminidase
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-
-
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beta-N-acetyl-D-hexosaminidase
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-
-
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beta-N-acetyl-hexosaminidase
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-
-
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beta-N-acetylgalactosaminidase
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-
-
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beta-N-acetylglucosaminidase
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-
-
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Beta-N-acetylhexosaminidase
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-
-
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beta-NAHA
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-
-
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Beta-NAHASE
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-
-
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chitobiase
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-
-
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Hex
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-
-
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hexosaminidase
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-
-
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hexosaminidase A
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-
-
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N-acetyl-beta-D-hexosaminidase
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-
-
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N-acetyl-beta-glucosaminidase
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-
-
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N-acetyl-beta-hexosaminidase
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-
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N-acetylhexosaminidase
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
O-glycosyl bond hydrolysis
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-
-
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SYSTEMATIC NAME
IUBMB Comments
beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase
Acts on N-acetylglucosides and N-acetylgalactosides.
CAS REGISTRY NUMBER
COMMENTARY hide
9012-33-3
c.f. EC 3.2.1.165
9027-52-5
deleted
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-methylumbelliferyl beta-D-glucosaminide + H2O
4-methylumbelliferone + D-glucosamine
show the reaction diagram
-
-
-
?
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
in affected cats with GM2 gangliosidosis, hexosaminidase beta-subunit mRNA levels are approximately 1.5times higher than normal, while beta-subunit protein levels are substantially reduced
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HEXB_FELCA
531
0
60427
Swiss-Prot
Secretory Pathway (Reliability: 5)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bradbury, A.M.; Morrison, N.E.; Hwang, M.; Cox, N.R.; Baker, H.J.; Martin, D.R.
Neurodegenerative lysosomal storage disease in European Burmese cats with hexosaminidase beta-subunit deficiency
Mol. Genet. Metab.
97
53-59
2009
Felis catus (P49614), Felis catus
Manually annotated by BRENDA team