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Information on EC 3.2.1.49 - alpha-N-acetylgalactosaminidase and Organism(s) Mus musculus and UniProt Accession Q9QWR8

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IUBMB Comments
The human lysosomal enzyme is involved in the degradation of blood type A epitope.
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This record set is specific for:
Mus musculus
UNIPROT: Q9QWR8
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
alpha-n-acetylgalactosaminidase, alpha-galnac, nagalase, envelope glycoprotein gp160, alpha-naga, alpha-galactosidase b, alpha-nagalase, alpha-galnacase i, alpha-nagal, alpha-galnacase ii, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-acetamido-2-deoxy-alpha-D-galactoside acetamidodeoxygalactohydrolase
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4-nitrophenyl-alpha-N-acetylgalactosaminidase
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alpha-acetylgalactosaminidase
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alpha-galactosidase B
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exo-alpha-N-acetylgalactosaminidase
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N-acetyl-alpha-D-galactosaminidase
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N-acetyl-alpha-galactosaminidase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of O-glycosyl bond
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SYSTEMATIC NAME
IUBMB Comments
alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase
The human lysosomal enzyme is involved in the degradation of blood type A epitope.
CAS REGISTRY NUMBER
COMMENTARY hide
9075-63-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Uniprot
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NAGAB_MOUSE
415
0
47235
Swiss-Prot
Secretory Pathway (Reliability: 1)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Cos-1 cells
expression in B-lymphoblast cell line
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hermann, T.; Schindler, D.; Tabe, H.; Onadera, O.; Igarashi, S.; Polack, A.; Zehnpfennig, D.; Tsuji S.
Molecular cloning, structural organization, sequence, chromosomal assignment, and expression of the mouse alpha-N-acetylgalactosaminidase gene
Gene
211
205-214
1998
Mus musculus
Manually annotated by BRENDA team
Wang, A.M.; Ioannou, Y.A.; Zeidner, K.M.; Desnick, R.J.
Murine alpha-N-acetylgalactosaminidase: Isolation and expression of a full-lenght cDNA and genomic organization: further evidence of an alpha galactosidase gene family
Mol. Genet. Metab.
65
165-173
1998
Mus musculus (Q9QWR8), Mus musculus
Manually annotated by BRENDA team