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Information on EC 3.2.1.46 - galactosylceramidase and Organism(s) Macaca mulatta and UniProt Accession O02791

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EC Tree
IUBMB Comments
cf. EC 3.2.1.62 glycosylceramidase.
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Select one or more organisms in this record: ?
This record set is specific for:
Macaca mulatta
UNIPROT: O02791
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Word Map
The taxonomic range for the selected organisms is: Macaca mulatta
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
galactocerebrosidase, galactosylceramidase, galactosylceramide beta-galactosidase, beta-galactocerebrosidase, galactocerebroside beta-galactosidase, gm1 ganglioside beta-galactosidase, lactosylceramidase i, cerebroside beta-galactosidase, beta-galactosylceramidase, galactosylceramidase i, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
beta-galactocerebrosidase
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beta-galactosylceramidase
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ceramidase, galacatosyl-
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ceramide galactosidase
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cerebroside beta-galactosidase
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cerebroside galactosidase
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galactoceramidase
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galactocerebrosidase
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galactocerebroside beta-galactosidase
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galactocerebroside galactosidase
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galactocerebroside-beta-D-galactosidase
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Galactosylceramidase
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galactosylceramidase I
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galactosylceramide beta-galactosidase
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galactosylcerebrosidase
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galcerase
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lactosylceramidase
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lactosylceramidase I
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of O-glycosyl bond
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
D-galactosyl-N-acylsphingosine galactohydrolase
cf. EC 3.2.1.62 glycosylceramidase.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-89-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-galactosyl-N-acylsphingosine + H2O
?
show the reaction diagram
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-
-
?
D-galactosyl-N-acylsphingosine + H2O
D-galactose + N-acylsphingosine
show the reaction diagram
-
-
-
?
galactocerebroside + H2O
D-galactose + N-acylceramide
show the reaction diagram
-
-
-
?
galactosylceramide + H2O
D-galactose + N-acylceramide
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-galactosyl-N-acylsphingosine + H2O
?
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
Uniprot
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GALC_MACMU
685
0
77090
Swiss-Prot
Mitochondrion (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
mutation in Krabbe disease
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
enzyme deficiency in globoid cell leucodystrophy or Krabbe disease
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Luzi, P.; Rafi, M.A.; Victoria, T.; Baskin, G.B.; Wenger, D.A.
Characterization of the rhesus monkey galactocerebrosidase (GALC) cDNA and gene and identification of the mutation causing globoid cell leukodystrophy (Krabbe disease) in this primate
Genomics
42
319-324
1997
Macaca mulatta (O02791), Macaca mulatta
Manually annotated by BRENDA team