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Information on EC 3.2.1.35 - hyaluronoglucosaminidase and Organism(s) Rattus norvegicus and UniProt Accession Q76HM9

for references in articles please use BRENDA:EC3.2.1.35
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IUBMB Comments
Also hydrolyses 1,4-beta-D-glycosidic linkages between N-acetyl-galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan.
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This record set is specific for:
Rattus norvegicus
UNIPROT: Q76HM9
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The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Synonyms
chondroitinase, testicular hyaluronidase, hyal1, hyal2, ph-20, hyal-1, rhuph20, spreading factor, hyal-2, mgea5, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hyaluronidase
-
chondritinase I
-
-
-
-
chondroitinase
-
-
-
-
HYAL 4
-
isoform
hyaluronidase
hyaluronidase-1
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hyaluronidase-2
-
hyaluronoglucosidase
-
-
-
-
Mu toxin
-
-
-
-
Sperm surface protein PH-20
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of O-glycosyl bond
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
hyaluronate 4-glycanohydrolase
Also hydrolyses 1,4-beta-D-glycosidic linkages between N-acetyl-galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan.
CAS REGISTRY NUMBER
COMMENTARY hide
37326-33-3
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
show the reaction diagram
-
-
-
?
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
show the reaction diagram
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide
-
dimethyl sulfoxide
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additional information
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the residual activities normalized to 100% at 0 concentrations of Terminalia chebula extract are reduced to 88% at 0.1 mg/ml, 78% at 0.5 mg/ml, 58 at 1 mg/ml, 49% at 1.5 mg/ml, 29% at 3 mg/ml, and 15% at 30 mg/ml
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
isoforms HYAL 3 is highly expressed in the renal papilla
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Hyal2 is partly expressed at the cell surface
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
Hyal2, through direct interactions with CD44 and possibly some pericellular hyaluronidase activity requiring acidic foci, suppresses the formation or the stability of the glycocalyx, modulates ezrin-radixin-moesin-related cytoskeletal interactions, and diminishes cell motility
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HYAL3_RAT
412
0
46207
Swiss-Prot
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
73000
primary band at about 73 kDa, gel filtration
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
hyaluronidase activity is elevated in dehydrated rats
hyaluronidase activity is elevated in dehydrated rats
hyaluronidase-1 activity is increased in the lungs of monocrotaline-challenged rats
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ormiston, M.L.; Slaughter, G.R.; Deng, Y.; Stewart, D.J.; Courtman, D.W.
The enzymatic degradation of hyaluronan is associated with disease progression in experimental pulmonary hypertension
Am. J. Physiol. Lung Cell Mol. Physiol.
298
L148-L157
2010
Rattus norvegicus (Q76HN1)
Manually annotated by BRENDA team
Duterme, C.; Mertens-Strijthagen, J.; Tammi, M.; Flamion, B.
Two novel functions of hyaluronidase-2 (Hyal2) are formation of the glycocalyx and control of CD44-ERM interactions
J. Biol. Chem.
284
33495-33508
2009
Rattus norvegicus (Q9Z2Q3)
Manually annotated by BRENDA team
Ruegheimer, L.; Olerud, J.; Johnsson, C.; Takahashi, T.; Shimizu, K.; Hansell, P.
Hyaluronan synthases and hyaluronidases in the kidney during changes in hydration status
Matrix Biol.
28
390-395
2009
Rattus norvegicus, Rattus norvegicus (Q76HM9), Rattus norvegicus (Q76HN1), Rattus norvegicus (Q9Z2Q3)
Manually annotated by BRENDA team
Srivastav, A.; Chandra, A.; Singh, M.; Jamal, F.; Rastogi, P.; Rajendran, S.M.; Bansode, F.W.; Lakshmi, V.
Inhibition of hyaluronidase activity of human and rat spermatozoa in vitro and antispermatogenic activity in rats in vivo by Terminalia chebula, a flavonoid rich plant
Reprod. Toxicol.
29
214-224
2010
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team