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Information on EC 3.2.1.35 - hyaluronoglucosaminidase and Organism(s) Mesobuthus martensii and UniProt Accession P86100

for references in articles please use BRENDA:EC3.2.1.35
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IUBMB Comments
Also hydrolyses 1,4-beta-D-glycosidic linkages between N-acetyl-galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan.
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This record set is specific for:
Mesobuthus martensii
UNIPROT: P86100
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Word Map
The taxonomic range for the selected organisms is: Mesobuthus martensii
The enzyme appears in selected viruses and cellular organisms
Synonyms
chondroitinase, testicular hyaluronidase, hyal1, hyal2, ph-20, hyal-1, rhuph20, spreading factor, hyal-2, mgea5, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
chondritinase I
-
-
-
-
chondroitinase
-
-
-
-
hyaluronidase
-
-
-
-
hyaluronoglucosidase
-
-
-
-
Mu toxin
-
-
-
-
Sperm surface protein PH-20
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of O-glycosyl bond
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
hyaluronate 4-glycanohydrolase
Also hydrolyses 1,4-beta-D-glycosidic linkages between N-acetyl-galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan.
CAS REGISTRY NUMBER
COMMENTARY hide
37326-33-3
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
hyaluronan + H2O
?
show the reaction diagram
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50
optimal activity
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HYAL1_MESMA
410
1
47433
Swiss-Prot
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
48696
x * 48696, using MALDI-TOF
48700
using MALDI-TOF
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 48696, using MALDI-TOF
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
using successive chromatography: gel filtration, anion exchange chromatography, cation exchange chromatography, reversed-phase HPLC
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Feng, L.; Gao, R.; Gopalakrishnakone, P.
Isolation and characterization of a hyaluronidase from the venom of Chinese red scorpion Buthus martensi
Comp. Biochem. Physiol. C
148
250-257
2008
Mesobuthus martensii (P86100), Mesobuthus martensii
Manually annotated by BRENDA team