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Disease on EC 3.2.1.23 - beta-galactosidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acantholysis
Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic.
Acidosis
Acidosis and increased plasma levels of beta-D-glucosidase and beta-D-galactosidase after hepatic inflow occlusion in the pig.
Ca(2+)/calmodulin-dependent protein kinase II contributes to intracellular pH recovery from acidosis via Na(+)/H(+) exchanger activation.
Coordinately increased lysozymuria and lysosomal enzymuria induced by maleic acid.
Acidosis, Renal Tubular
Coordinately increased lysozymuria and lysosomal enzymuria induced by maleic acid.
Acquired Immunodeficiency Syndrome
Diagnosis of HIV-1 infection with whole saliva by detection of antibody IgG to HIV-1 with ultrasensitive enzyme immunoassay using recombinant reverse transcriptase as antigen.
Immune complex transfer enzyme immunoassay for antibody IgG to HIV-1 gp41 antigen using synthetic peptides as antigens.
Modification of sweet acidophilus milk to improve utilization by lactose-intolerant persons.
Reactivity of E. coli-derived trans-activating protein of human T lymphotropic virus type III with sera from patients with acquired immune deficiency syndrome.
Acute Kidney Injury
Mechanisms and consequences of oxidant-induced renal preconditioning: an Nrf2-dependent, P21-independent, anti-senescence pathway.
Adenocarcinoma
Adenovirus-mediated E2F-1 gene transfer induces an apoptotic response in human gastric carcinoma cells that is enhanced by cyclin dependent kinase inhibitors.
Alteration in glycosidases from well-differentiated colorectal adenocarcinoma of rat.
BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion.
E2F-1 gene therapy induces apoptosis and increases chemosensitivity in human pancreatic carcinoma cells.
Glucocorticoid-like effects of antihepatocarcinogen Rotenone are mediated via enhanced serum corticosterone levels: Molecular Fitting and Receptor Activation Studies.
Growth characteristics in the initial stage of micrometastasis formation by bacterial LacZ gene-tagged rat prostatic adenocarcinoma cells.
Highly attenuated modified vaccinia virus Ankara (MVA) as an effective recombinant vector: a murine tumor model.
Human Barrett's Adenocarcinoma of the Esophagus, Associated Myofibroblasts, and Endothelium Can Arise from Bone Marrow-Derived Cells After Allogeneic Stem Cell Transplant.
IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines: enhancement by simultaneous B7-1 expression.
Preparative in vitro generation of lacto-series type 1 chain glycolipids catalyzed by beta 1----3-galactosyltransferase from human colonic adenocarcinoma Colo 205 cells.
Production and characterization of monoclonal antibody to a 60-kD glycoprotein in ovarian carcinoma.
The transmembrane domains of Sindbis virus envelope glycoproteins induce cell death.
Tumor necrosis factor receptor p75 mediates cell-specific activation of nuclear factor kappa B and induction of human cytomegalovirus enhancer.
Two CEA cross-reacting antigens: differences in absorbing the same anti-CEA serum.
[The relationship between hydrolases and invasion of gastric carcinoma]
Adenocarcinoma of Lung
Characterization of the human surfactant protein D promoter: transcriptional regulation of SP-D gene expression by glucocorticoids.
Inhibition of oncogenic K-ras signaling by aerosolized gene delivery in a mouse model of human lung cancer.
Transforming growth factor beta triggers two independent-senescence programs in cancer cells.
Adenoma
Detection of Oncogene-Induced Senescence In Vivo.
Secretory activity of isolated thyroid adenomas.
Adenoviridae Infections
Adenovirus-mediated arterial gene transfer does not require prior injury for submaximal gene expression.
Development and assessment of a general theory of cervical carcinogenesis utilizing a severe combined immunodeficiency murine-human xenograft model.
Light-induced adenovirus gene transfer, an efficient and specific gene delivery technology for cancer gene therapy.
Major effects of TPO delivered by a single injection of a recombinant adenovirus on prevention of septicemia and anemia associated with myelosuppression in mice: risk of sustained expression inducing myelofibrosis due to immunosuppression.
Transplantation of genetically marked cardiac muscle cells.
Adrenocortical Carcinoma
DAX1 gene expression upregulated by steroidogenic factor 1 in an adrenocortical carcinoma cell line.
Adrenoleukodystrophy
Adrenoleukodystrophy and beta-galactosidase deficiency: patient and carrier.
Electron microscopic examination of skin and conjunctival biopsy specimens in neuronal storage diseases.
[A case of adrenoleukodystrophy and a carrier with decreased activity of beta-galactosidase]
African Swine Fever
Genetic manipulation of African swine fever virus: construction of recombinant viruses expressing the beta-galactosidase gene.
AIDS-Related Complex
Diagnosis of HIV-1 infection with whole saliva by detection of antibody IgG to HIV-1 with ultrasensitive enzyme immunoassay using recombinant reverse transcriptase as antigen.
Immune complex transfer enzyme immunoassay for antibody IgG to HIV-1 gp41 antigen using synthetic peptides as antigens.
Albuminuria
Urinary glycosaminoglycans, sialic acid and lysosomal enzymes increase in nonalbuminuric diabetic patients.
alpha-Mannosidosis
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs.
alpha-n-acetylglucosaminidase deficiency
The atomic model of the human protective protein/cathepsin A suggests a structural basis for galactosialidosis.
Alzheimer Disease
Cerebrospinal fluid beta-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies.
High-resolution scanner for neuroanatomical analysis.
Anaphylaxis
[Platelets, lysosomal enzymes and anaphylactic shock in the rat]
Anemia
Anomalous cell surface structure of sickle cell anemia erythrocytes as demonstrated by cell surface labeling and endo-beta-galactosidase treatment.
Decreased urinary excretion of beta-glucuronidase in sickle cell anemia in Nigeria.
Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne muscular dystrophy.
Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice.
Anemia, Dyserythropoietic, Congenital
Defect in glycosylation of erythrocyte membrane proteins in congenital dyserythropoietic anaemia type II (HEMPAS).
Isolation and characterization of poly-N-acetyllactosaminylceramides accumulated in the erythrocytes of congenital dyserythropoietic anemia type II patients.
Anemia, Sickle Cell
Anomalous cell surface structure of sickle cell anemia erythrocytes as demonstrated by cell surface labeling and endo-beta-galactosidase treatment.
Decreased urinary excretion of beta-glucuronidase in sickle cell anemia in Nigeria.
Aneurysm
Coronary artery aneurysm induced by Kawasaki disease in children show features typical senescence.
Gene transfer for experimental saccular aneurysms.
Angiofibroma
Cellular senescence of angiofibroma stroma cells from patients with tuberous sclerosis.
Angiokeratoma
Angiokeratoma corporis diffusum in GM1 gangliosidosis, type 1.
beta-Galactosidase and neuraminidase deficiency associated with angiokeratoma corporis diffusum.
Anthrax
Cloning and characterization of a gene whose product is a trans-activator of anthrax toxin synthesis.
Aortic Valve Stenosis
In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosis.
Appendicitis
Histochemical study of expression of lectin-reactive carbohydrate epitopes and glycoligand-binding sites in normal human appendix vermiformis, colonic mucosa, acute appendicitis and colonic adenoma.
Arteritis
Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model.
Arthritis
Adeno-associated virus pseudotype 5 vector improves gene transfer in arthritic joints.
Adenovirus-based overexpression of tissue inhibitor of metalloproteinases 1 reduces tissue damage in the joints of tumor necrosis factor alpha transgenic mice.
Adenovirus-mediated gene transfer of adiponectin reduces the severity of collagen-induced arthritis in mice.
Adenovirus-mediated gene transfer of CTLA-4Ig fusion protein in the suppression of experimental autoimmune arthritis.
Chondrocyte antigen expression, immune response and susceptibility to arthritis.
Disease-inducible transgene expression from a recombinant adeno-associated virus vector in a rat arthritis model.
Modifications in adenoviral coat fiber proteins and transcriptional regulatory sequences enhance transgene expression.
[Recombinant adenovirus-mediated gene transfer suppresses experimental arthritis]
Arthritis, Experimental
Adenovirus-mediated gene transfer of adiponectin reduces the severity of collagen-induced arthritis in mice.
Direct synovial gene transfer with retroviral vectors in rat adjuvant arthritis.
Arthritis, Rheumatoid
Activity of lysosomal exoglycosidases in serum and synovial fluid in patients with chronic Lyme and rheumatoid arthritis.
Arthus Reaction
Histoenzymology of the lung. II. The behaviour of lung hydrolytic enzymes during some experimental pulmonary processes.
Aspartylglucosaminuria
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs.
Asthma
ELISA in diagnosis of respiratory allergy. A comparison with RAST and skin tests.
[Correlations between lysosomal enzymes and cyclic nucleotides during allergies in children]
[Lysosomal leukocyte glycosidases in childhood bronchial asthma]
Astrocytoma
Expression of p57(KIP2) potently blocks the growth of human astrocytomas and induces cell senescence.
Gene transfer in astrocytes: comparison between different delivering methods and expression of the HIV-1 protein Nef.
Increased activity of lysosomal glycohydrolases in glioma tissue and surrounding areas from human brain.
Ataxia
Inheritance of an ovine lysosomal storage disease associated with deficiencies of beta-galactosidase and alpha-neuraminidase.
Localized beta-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry-red spot--a new variant of GM1-gangliosidosis?
Lysosomal enzymes in ataxia: discovery of two new cases of late onset hexosaminidase A and B deficiency (adult Sandhoff disease) in French Canadians.
Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver.
Ataxia Telangiectasia
Cellular response to irinotecan in colon cancer cell lines showing differential response to 5-fluorouracil.
Atherosclerosis
Efficacy and limitations of senolysis in atherosclerosis.
Selective neointimal gene transfer in an avian model of vascular injury.
Atrial Fibrillation
Inhibitory G protein overexpression provides physiologically relevant heart rate control in persistent atrial fibrillation.
Autoimmune Diseases
Resting CD8 T cells recognize beta-galactosidase expressed in the immune-privileged retina and mediate autoimmune disease when activated.
Retinal expression of a neo-self antigen, beta-galactosidase, is not tolerogenic and creates a target for autoimmune uveoretinitis.
Bacterial Infections
Discovery of new beta-D-galactosidase inhibitors via pharmacophore modeling and QSAR analysis followed by in silico screening.
Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster.
beta-galactosidase deficiency
A benign deficiency of typeB beta-galactosidase in human liver.
A case of GM1-gangliosidosis type I: glycosphingolipid profiles of urine and transformed lymphocytes and beta-D-galactosidase activities in peripheral lymphocytes, cultured skin fibroblasts and transformed lymphocytes.
A comparative study of sialyloligosaccharides isolated from sialidosis and galactosialidosis urine.
A family with beta-galactosidase deficiency: three adults with atypical clinical patterns.
A fluorimetric enzyme assay for the diagnosis of Morquio disease type A (MPS IV A).
A microassay for acid beta-galactosidase activity toward asialofetuin.
A quantitative cytochemical assay of beta-galactosidase in single cultured human skin fibroblasts.
A simple method of lysosomal hydrolase assay in a single somatic cell and its application.
A spreadable, non-integrative and high copy number shuttle vector for Sulfolobus solfataricus based on the genetic element pSSVx from Sulfolobus islandicus.
A two-year-old patient with an atypical expression of GM1-beta-galactosidase deficiency: biochemical, immunological, and cell genetic studies.
Adrenoleukodystrophy and beta-galactosidase deficiency: patient and carrier.
Adult GM1 gangliosidosis: clinical and biochemical studies on two patients and comparison to other patients called variant or adult GM1 gangliosidosis.
Application of epithelial cells in culture to the biochemical studies of lysosomal hydrolase deficiencies.
Atypical adult GM1 gangliosidosis: biochemical comparison with other forms of primary beta-galactosidase deficiency.
Atypical expression of beta-galactosidase deficiency in a child with Hurler-like features but without neurological abnormalities.
Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis.
Beta-galactosidase deficiencies and novel GLB1 mutations in three Chinese patients with Morquio B disease or GM1 gangliosidosis.
Beta-galactosidase deficiency in a Korat cat: a new form of feline GM1-gangliosidosis.
beta-Galactosidase deficiency in an adult: a biochemical and somatic cell genetic study on a variant of GM1-gangliosidosis.
Beta-galactosidase deficiency in GM1 gangliosidosis of Friesian calves.
beta-Galactosidase deficiency in juvenile and adult patients. Report of six Japanese cases and review of literature.
Beta-galactosidase deficiency in the hurler syndrome.
beta-Galactosidase deficiency: An approach to chaperone therapy.
Beta-galactosidase deficiency: prolonged survival in three patients following early central nervous system deterioration.
Beta-galactosidase deficiency: studies of two patients with prolonged survival.
Beta-galactosidase-deficient mouse as an animal model for GM1-gangliosidosis.
Biochemical comparison of the dysmorphic type with the normosomatic type of sialidosis.
Biochemical, immunological, and structural studies on a sphingolipid activator protein (SAP-1).
Cardiac involvement in diseases characterized by beta-galactosidase deficiency.
Carrier detection of sialidosis with partial beta-galactosidase deficiency by the assay of lysosomal sialidase in lymphocytes.
Chaperone therapy for neuronopathic lysosomal diseases: competitive inhibitors as chemical chaperones for enhancement of mutant enzyme activities.
Chemical pathology of krabbe's disease. IV. Studies of galactosylceramide and lactosylceramide BETA-galactosidases in brain, white blood cells and aminotic fluid cells.
Chronic GM1 gangliosidosis presenting as dystonia: I. Clinical and pathological features.
Clinical and molecular heterogeneity in hereditary beta-galactosidase deficiency.
Combined sialidase (neuraminidase) and beta-galactosidase deficiency. Clinical, morphological and enzymological observations in a patient.
Complementation analysis of beta-galactosidase deficiency by means of histochemical method.
Complementation studies with enucleated fibroblasts from different variants of beta-galactosidase deficiency.
Corneal clouding in GM1-generalized gangliosidosis.
Correction of acid beta-galactosidase deficiency in GM1 gangliosidosis human fibroblasts by retrovirus vector-mediated gene transfer: higher efficiency of release and cross-correction by the murine enzyme.
Detection of acid-beta-galactosidase activity in viable human fibroblasts by flow cytometry.
Development and medical application of unsaturated carbaglycosylamine glycosidase inhibitors.
Disentangling molecular and clinical stratification patterns in beta-galactosidase deficiency.
Dystonia and parkinsonism in GM1 type 3 gangliosidosis.
Effects of exogenous beta-galactosidase on cultured fibroblasts with beta-galactosidase deficiency.
Effects of thiol protease inhibitors on intracellular degradation of exogenous beta-galactosidase in cultured human skin fibroblasts.
Expression and characterization of 14 GLB1 mutant alleles found in GM1-gangliosidosis and Morquio B patients.
Expression of beta-galactosidase in preimplantation ovine and porcine embryos.
Fibroblast screening for chaperone therapy in beta-galactosidosis.
Fine structure of meganeurites and secondary growth processes in feline GM1-gangliosidosis.
Four novel mutations in patients from the Middle East with the infantile form of GM1-gangliosidosis.
Ganglioside GM1 metabolism in living human fibroblasts with beta-galactosidase deficiency.
Generalized gangliosidosis: acid beta-galactosidase deficiency with early onset, rapid mental deterioration and minimal bone dysplasia.
Generalized gangliosidosis: beta-galactosidase deficiency.
GM1 gangliosidosis in shiba dogs.
GM1 gangliosidosis type 2 in two siblings.
GM1-ganglioside accumulation and beta-galactosidase deficiency in a case of GM1-gangliosidosis (Landing disease).
GM1-gangliosidosis in Alaskan huskies: clinical and pathologic findings.
Homologous modeling of the lysosomal protective protein/carboxypeptidase L: structural and functional implications of mutations identified in galactosialidosis patients.
Hunter's syndrome: beta-galactosidase deficiency in skin.
Immunoelectron microscopical localization of lysosomal beta-galactosidase and its precursor forms in normal and mutant human fibroblasts.
Incorporation and degradation of GM1 ganglioside and asialoGM1 ganglioside in cultured fibroblasts from normal individuals and patients with beta-galactosidase deficiency.
Infantile cardiomyopathy and neuromyopathy with beta-galactosidase deficiency.
Infantile G(M1) gangliosidosis: complete morphology and histochemistry of two autopsy cases, with particular reference to delayed central nervous system myelination.
Intergenic complementation after fusion of fibroblasts from different patients with beta-galactosidase deficiency.
Interspecific genetic complementation analysis of human and sheep fibroblasts with beta-galactosidase deficiency.
Intracellular processing and maturation of mutant gene products in hereditary beta-galactosidase deficiency (beta-galactosidosis).
Km defect in neuraminidase of dysmorphic type sialidosis with and without beta-galactosidase deficiency.
Landing disease, GM1 generalized gangliosidosis, and malabsorption syndrome.
Letter: Beta-galactosidase deficiency in young adults.
Localized beta-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry-red spot--a new variant of GM1-gangliosidosis?
Lymphoblastoid cell lines, transformed by Epstein-Barr virus, in the enzymatic study of hereditary lysosomal storage diseases.
Lysosomal enzyme activities among Chinese: leukocyte alpha-galactosidase and beta-galactosidase.
Lysosomal sialidase deficiency in sialidosis with partial beta-galactosidase deficiency.
Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver.
Macular cherry-red spots and myoclonus with dementia: coexistent neuraminidase and beta-galactosidase deficiencies.
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs.
Meganeurites and other aberrant processes of neurons in feline GM1-gangliosidosis: a Golgi study.
Molecular basis of GM1 gangliosidosis and Morquio disease, type B. Structure-function studies of lysosomal beta-galactosidase and the non-lysosomal beta-galactosidase-like protein.
Molecular form and subcellular distribution of acid beta-galactosidase in fibroblasts from patients with GM1 gangliosidosis, Morquio B disease and galactosialidosis.
Morphological analysis of corneal opacity in Shiba dog with GM1 gangliosidosis.
Morquio syndrome (mucopolysaccharidosis IV B) associated with beta-galactosidase deficiency. Report of two cases.
Morquio's disease type B (beta-galactosidase deficiency) in three siblings.
Morquio-B disease, spondyloepiphyseal dysplasia associated with acid beta-galactosidase deficiency. Report of three cases in one family.
Morquio-B syndrome (MPS-IV B) associated with beta-galactosidase deficiency in two siblings.
Morquio-like syndrome with beta galactosidase deficiency and normal hexosamine sulfatase activity: mucopolysacchariodosis IVB.
Mucolipidosis I: studies of sialidase activity and a prenatal diagnosis.
Multiple carbohydrate-cleaving specificities in human acidic and neutral glycosidases.
Neuraminidase deficiency and accumulation of sialic acid in lymphocytes in adult type sialidosis with partial beta-galactosidase deficiency.
Neuraminidase in mucolipidoses: normal activity in frozen autopsy tissues from three patients with I-cell disease and adult beta-galactosidase deficiency.
Neurochemical abnormality in I-cell disease: chemical analysis and a possible importance of beta-galactosidase deficiency.
Neurological manifestations of knockout mice with beta-galactosidase deficiency.
Neuronal GM1 gangliosidosis in a Siamese cat with beta-galactosidase deficiency.
Neuronal-visceral GM1 gangliosidosis in a dog with beta-galactosidase deficiency.
Neurovisceral and skeletal GM1-gangliosidosis in dogs with beta-galactosidase deficiency.
Normal serum beta-galactosidase in juvenile GM1 gangliosidosis.
Partial characterization and studies of fibroblast and leucocyte neuraminidase activities towards sialyloligosaccharides in adult sialidosis and mucolipidosis II and III.
Pattern of beta-galactosidase deficiency in GM1-gangliosidosis type 1 and type 2.
Prenatal diagnosis of sialidosis with combined neuraminidase and beta-galactosidase deficiency.
Primary and secondary elastin-binding protein defect leads to impaired elastogenesis in fibroblasts from GM1-gangliosidosis patients.
Processing of human beta-galactosidase in GM1-gangliosidosis and Morquio B syndrome.
Recent advances in Dyggve-Melchior-Clausen syndrome.
Simple laboratory determination of excess oligosacchariduria.
Spondyloepiphyseal dysplasia, corneal clouding, normal intelligence and acid beta-galactosidase deficiency.
Substrate specificities of the two genetically distinct human brain beta-galactosidases.
The complementation of beta-galactosidase in fused cells of mucolipidosis II with another variants of beta-galactosidase deficiency using new single cell enzyme assay.
The genetic defect in the various types of human beta-galactosidase deficiency.
The specificity of beta-galactosidase in the degradation of gangliosides.
Three cases of beta-galactosidase deficiency.
Three GM1-gangliosidoses and a variant of beta-galactosidase deficiency.
Turnover of beta-galactosidase in fibroblasts from patients with genetically different types of beta-galactosidase deficiency.
Twenty-one novel mutations in the GLB1 gene identified in a large group of GM1-gangliosidosis and Morquio B patients: possible common origin for the prevalent p.R59H mutation among gypsies.
Type 3 (adult) GM1 gangliosidosis: case report.
Urinary oligosaccharide screening in patients with beta-galactosidase deficiency.
Use of active site-directed inhibitors to study in situ degradation of glycoproteins by the perfused rat liver.
Variable clinical presentation in lysosomal storage disorders.
[A case of adult type sialidosis with partial beta-galactosidase deficiency without myoclonus]
[Adult mucolipidosis with beta-galactosidase deficiency: a clinical report, with studies of urinary sialic acid-rich substances (author's transl)]
[Beta-galactosidase deficiency in the small intestine and its enzyme therapy]
[Beta-galactosidase deficiency]
[beta-Galactosidosis (acid beta-galactosidase deficiency: GM1 gangliosidosis, Morquio B disease)]
[Clinical, ultrastructural and biochemical study of a case of GM1 type 2 gangliosidosis]
[Gangliosidosis GM1. Clinical, radiologic, biochemical and histological studies in two cases (author's transl)]
[Molecular genetics of beta-galactosidase deficiency (GM1-gangliosidosis and Morquio syndrome type B)]
[Molecular pathology of neurogenetic diseases]
[Morquio syndrome moderated by beta galactosidase deficiency. Mucopolysaccharidosis (type IV B) or oligosaccharidosis]
[Morquio syndrome, beta-galactosidase deficiency]
[The metabolism of radiolabelled GM1-ganglioside in cultured skin fibroblasts from controls and patients with GM1-gangliosidosis]
[Wolman disease, Fabry disease and beta-galactosidase deficiency]
beta-glucosidase deficiency
Chaperone therapy for neuronopathic lysosomal diseases: competitive inhibitors as chemical chaperones for enhancement of mutant enzyme activities.
beta-Mannosidosis
Formation of bacterial membrane ice-nucleating lipoglycoprotein complexes.
Biliary Atresia
Cellular senescence in livers from children with end stage liver disease.
Blister
Acid hydrolases in blister fluid. II. Characterization and quantification of glycoside hydrolases.
Adenoviral-mediated gene transfer to the filtering bleb in rabbits.
Blood Platelet Disorders
Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver.
Bone Cysts
The role of lysosomes in the pathogenesis of unicameral bone cysts.
Bone Diseases, Developmental
Generalized gangliosidosis: acid beta-galactosidase deficiency with early onset, rapid mental deterioration and minimal bone dysplasia.
The effects of acid glycosaminoglycans on neonatal calvarian cultures--a role of keratan sulfate in Morquio syndrome?
Bone Resorption
Identification of gene pathways altered by deletion of the androgen receptor specifically in mineralizing osteoblasts and osteocytes in mice.
Impaired osteoblastogenesis potential of progenitor cells in skeletal unloading is associated with alterations in angiogenic and energy metabolism profile.
Influence of diphenylhydantoin on lysosomal enzyme release during bone resorption in vitro.
Brain Abscess
Production of specific glycosidase activities by Streptococcus intermedius strain UNS35 grown in the presence of mucin.
Brain Injuries, Traumatic
Adenovirus-mediated transfer and expression of beta-gal in injured hippocampus after traumatic brain injury in mice.
Increased vulnerability of NFH-LacZ transgenic mouse to traumatic brain injury-induced behavioral deficits and cortical damage.
Brain Ischemia
Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2.
Postischemic gene transfer of midkine, a neurotrophic factor, protects against focal brain ischemia.
Brain Neoplasms
In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.
Breast Neoplasms
A new method for determining the status of p53 in tumor cell lines of different origin.
A novel serum assay for breast epithelial antigen using a fusion protein.
Adenoviral-mediated gene therapy with Ad5CMVp53 and Ad5CMVp21 in combination with standard therapies in human breast cancer cell lines.
Adenovirus-mediated gene transfer to human breast tumor cells: an approach for cancer gene therapy and bone marrow purging.
Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer.
Apoptosis, autophagy, accelerated senescence and reactive oxygen in the response of human breast tumor cells to adriamycin.
Beta-galactosidase and alpha-mannosidase inhibit formation of multicellular nodules in breast cancer cell cultures.
Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter.
Correlation between extent of osteolytic damage and metastatic burden of human breast cancer metastasis in nude mice: real-time PCR quantitation.
Cyclin E expression and chemotherapeutic sensitivity in breast cancer cells.
Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization.
Functional identification of a BAC clone from 16q24 carrying a senescence gene SEN16 for breast cancer cells.
Heat-directed gene targeting of adenoviral vectors to tumor cells.
Heat-directed suicide gene therapy for breast cancer.
MCF-7 breast carcinoma cells overexpressing FGF-1 form vascularized, metastatic tumors in ovariectomized or tamoxifen-treated nude mice.
Measurement of tumor load and distribution in a model of cancer-induced osteolysis: a necessary precaution when testing novel anti-resorptive therapies.
p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells.
Plasma Escherichia coli beta-galactosidase as a marker of tumor burden and response to experimental anti-neoplastic therapy in nude mice xenografted with lacZ transduced human tumor cells.
Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ.
Reporter gene assay demonstrates functional differences in estrogen receptor activity in purified breast cancer cells: a pilot study.
Selective isolation of transiently transfected cells from a mammalian cell population with vectors expressing a membrane anchored single-chain antibody.
Serum beta-N-acetylglucosaminidase, beta-D-glucosidase, alpha-D-glucosidase, beta-D-fucosidase, alpha-L-fucosidase and beta-D-galactosidase levels in acute viral hepatitis, pancreatitis, myocardial infarction and breast cancer.
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.
Stable transgene expression in tumors and metastases after transduction with lentiviral vectors based on human immunodeficiency virus type 1.
Suicide gene therapy using E. coli beta-galactosidase.
The histochemistry of glycosidases in human benign and malignant breast tissue.
Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models.
Bronchitis
Identification of a new membrane-associated polypeptide specified by the coronavirus infectious bronchitis virus.
Bronchopulmonary Dysplasia
Lysosomal enzymes in preterm infants with bronchopulmonary dysplasia: a potential diagnostic marker.
Burkitt Lymphoma
Suitability of Epstein-Barr virus-based episomal vectors for expression of cytokine genes in human lymphoma cells.
Carcinogenesis
Cell-free whey from milk fermented with Bifidobacterium breve C50 used to modify the colonic microflora of healthy subjects.
[Interaction between lysosomes and cell nucleus during diethylnitrosamine-induced carcinogenesis. I. Changes in subcellular distribution of the lysosomal enzymes acid deoxyribonuclease and beta-galactosidase during acute intoxication by diethylnitrosamine]
Carcinoid Tumor
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Carcinoma
5-fluorouracil and hydroxyurea enhance adenovirus-mediated transgene expression in colon and hepatocellular carcinoma cells.
Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma.
Adenovirus-mediated gene transfer into an experimental pancreatic tumour.
Adenovirus-mediated ribonucleotide reductase R1 gene therapy of human colon adenocarcinoma.
Beta-galactosidase as a marker of HSP70 promoter induction in Dunning R3327 prostate carcinoma cells.
Carbohydrate-mediated adhesion of human colon carcinoma cells to human liver sections.
Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity.
Development of micrometastases: earliest events detected with bacterial lacZ gene-tagged tumor cells.
Differential suppression of human cervical cancer cell growth by adenovirus delivery of p53 in vitro: arrest phase of cell cycle is dependent on cell line.
Differential transfection efficiency rates of the GM-CSF gene into human renal cell carcinoma lines by lipofection.
Does pH 6 beta-galactosidase activity indicate cell senescence?
Effect of low-dose preirradiation on induction of the HSP70B-LacZ fusion gene in human cells treated with heat shock.
Enhanced oncogenicity of Asian-American human papillomavirus 16 is associated with impaired E2 repression of E6/E7 oncogene transcription.
Enhanced thermal stability of lysosomal beta-D-galactosidase in parenchymal cells of tumour bearing mice.
Enhancing efficacy of recombinant anticancer vaccines with prime/boost regimens that use two different vectors.
Envelope and long terminal repeat sequences of an infectious murine leukemia virus from a human SCLC cell line: implications for gene transfer.
Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization.
Evaluation of permissiveness and cytotoxic effects in equine chondrocytes, synovial cells, and stem cells in response to infection with adenovirus 5 vectors for gene delivery.
Evaluation of topical gene therapy for head and neck squamous cell carcinoma in an organotypic model.
Fractional laser exposure induces neutrophil infiltration (N1 phenotype) into the tumor and stimulates systemic anti-tumor immune response.
Gene transfer of the vascular endothelial growth factor receptor flt-1 suppresses pulmonary metastasis associated with lung growth.
Generation of an intensely potent anthracycline by a monoclonal antibody-beta-galactosidase conjugate.
In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors.
Increased serum alpha-L-fucosidase and beta-N-acetylglucosaminidase activities in diabetic, cirrhotic and gastric cancer patients.
Induction of senescence-like state and suppression of telomerase activity through inhibition of HPV E6/E7 gene expression in cells immortalized by HPV16 DNA.
Inhibition of cell-proliferation by an adenovirus vector expressing the human wild type-p53 protein.
Inhibition of tumorigenicity and metastasis of human bladder cancer growing in athymic mice by interferon-beta gene therapy results partially from various antiangiogenic effects including endothelial cell apoptosis.
Intracellular production of DNA enzyme by a novel single-stranded DNA expression vector.
Invasiveness by lacZ transfected non-small-cell lung cancer cells into human bronchial tissues in vitro.
Localization of binding sites of Ulex europaeus I, Helix pomatia and Griffonia simplicifolia I-B4 lectins and analysis of their backbone structures by several glycosidases and poly-N-acetyllactosamine-specific lectins in human breast carcinomas.
Low-volume jet injection for efficient nonviral in vivo gene transfer.
MCF-7 breast carcinoma cells overexpressing FGF-1 form vascularized, metastatic tumors in ovariectomized or tamoxifen-treated nude mice.
MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence.
Modification to the capsid of the adenovirus vector that enhances dendritic cell infection and transgene-specific cellular immune responses.
Nonviral in vivo gene delivery into tumors using a novel low volume jet-injection technology.
Occurrence of antibodies to L1, L2, E4 and E7 gene products of human papillomavirus types 6b, 16 and 18 among cervical cancer patients and controls.
Persistent, antigen-specific, therapeutic antitumor immunity by dendritic cells genetically modified with an adenoviral vector to express a model tumor antigen.
Phospholipid- and fatty acid-composition in the erythrocyte membrane of the one-humped camel [Camelus dromedarius] and its influence on vesicle properties prepared from these lipids.
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Real-time polymerase chain reaction quantitation of relative expression of genes modulated by p53 using SYBR Green I.
Recruitment of human umbilical vein endothelial cells and human primary fibroblasts into experimental tumors growing in SCID mice.
Regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer model.
Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT.
Senescence-associated beta-galactosidase is lysosomal beta-galactosidase.
Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells.
Stable transgene expression in tumors and metastases after transduction with lentiviral vectors based on human immunodeficiency virus type 1.
Studies of the activities of lysosomal enzymes in serum and buccal pouch tissue of hamsters during 7,12-dimethylbenz[a]anthracene-induced carcinogenesis.
Studies on variations of glycoproteins and lysosomal hydrolases in human uterine cervical carcinoma.
Suicide gene therapy for human oral squamous cell carcinoma cell lines with adeno-associated virus vector.
Systemic dissemination of viral vectors during intratumoral injection.
The histochemistry of glycosidases in human benign and malignant breast tissue.
Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models.
Transduction of normal and malignant oral epithelium by an adenovirus vector: the effect of dose and treatment time on transduction efficiency and tissue penetration.
Transgenic expression of 15-lipoxygenase 2 (15-LOX2) in mouse prostate leads to hyperplasia and cell senescence.
Ultrasound facilitates transduction of naked plasmid DNA into colon carcinoma cells in vitro and in vivo.
Wild-type p53 and p73 negatively regulate expression of proliferation related genes.
[Immunohistochemical studies on non neoplastic and neoplastic gastric mucosa. Determination of embryonic and specific antigens (author's transl)]
[Reporter genes transfer into human squamous cell carcinoma of larynx factor receptor mediated non-viral GE7 polypeptide delivery system with a new epidermal growth]
[The mechanism of bystander effect in herpes simplex virus thymidine kinase/ganciclovir-mediated gene therapy]
[The relationship between hydrolases and invasion of gastric carcinoma]
[Transcriptional inhibition of human papilloma virus in cervical carcinoma cells reactivates functions of the tumor suppressor p53]
Carcinoma, Bronchogenic
Highly selective glycosylated prodrugs of cytostatic CC-1065 analogues for antibody-directed enzyme tumor therapy.
Carcinoma, Ehrlich Tumor
Glycosidases of Ehrlich ascites tumor cells and ascitic fluid--purification and substrate specificity of alpha-N-acetylgalactosaminidase and alpha-galactosidase: comparison with coffee bean alpha-galactosidase.
Lysosomes: a possible target for psoralen photodamage.
Carcinoma, Embryonal
DNA rearrangement activity during retinoic acid-induced neural differentiation of P19 mouse embryonal carcinoma cells.
Expression pattern of SR alpha promoter in human embryonal carcinoma and transgenic tissues in mice.
Regulation of the mouse cellular retinoic acid-binding protein-I gene by thyroid hormone and retinoids in transgenic mouse embryos and P19 cells.
Carcinoma, Endometrioid
DNA damage detected with gammaH2AX in endometrioid adenocarcinoma cell lines.
Carcinoma, Hepatocellular
5-fluorouracil and hydroxyurea enhance adenovirus-mediated transgene expression in colon and hepatocellular carcinoma cells.
A potential approach for gene therapy targeting hepatoma using a liver-specific promoter on a retroviral vector.
Adenovirus-mediated overexpression of murine cyclic nucleotide phosphodiesterase 3B.
Aryl hydrocarbon receptor ligand activity of polycyclic aromatic ketones and polycyclic aromatic quinones.
Cyclin-dependent kinase site-regulated signal-dependent nuclear localization of the SW15 yeast transcription factor in mammalian cells.
Demonstration of the presence of protease-cutting site in the spacer of hepatitis B viral Pol protein.
Development of pyrrolo[2,1-c][1,4]benzodiazepine beta-galactoside prodrugs for selective therapy of cancer by ADEPT and PMT.
Does pH 6 beta-galactosidase activity indicate cell senescence?
Effects of overexpression of the amino-terminal fragment of apolipoprotein B on apolipoprotein B and lipoprotein production.
Enhanced antitumor effect of EGF R-targeted p21WAF-1 and GM-CSF gene transfer in the established murine hepatoma by peritumoral injection.
Evidence for an inhibitory feedback loop regulating simian virus 40 large T-antigen fusion protein nuclear transport.
Glycosidases in normal and regenerating chicken liver, hepatoma Mc-29, Rous sarcoma, in turkey poult liver and hemocytoblastomes, provoked by the leukosis virus strain Mc-31.
Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study.
Hepatitis B virus X protein overcomes stress-induced premature senescence by repressing p16(INK4a) expression via DNA methylation.
In vitro and in vivo hepatoma cell-specific expression of a gene transferred with an adenoviral vector.
In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene.
Kinetic characterization of the human retinoblastoma protein bipartite nuclear localization sequence (NLS) in vivo and in vitro. A comparison with the SV40 large T-antigen NLS.
Novel properties of the nucleolar targeting signal of human angiogenin.
Nuclear transport kinetics depend on phosphorylation-site-containing sequences flanking the karyophilic signal of the Simian virus 40 T-antigen.
Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells.
Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes.
Rapid production of interleukin-2-secreting tumor cells by herpes simplex virus-mediated gene transfer: implications for autologous vaccine production.
Retroviral delivery of DNA into the livers of transgenic mice bearing premalignant and malignant hepatocellular carcinomas.
Serum and host liver activities of glycosidases and sialyltransferases in animals bearing transplantable tumors.
Systemic genetic transfer of p21WAF-1 and GM-CSF utilizing of a novel oligopeptide-based EGF receptor targeting polyplex.
Transactivation of the early SV40 promoter by avian infectious laryngotracheitis virus in avian hepatoma cells.
Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype.
[The influence of tumor growth on natural cytotoxicity and activity of some lysosomal enzymes of human effector cells and the C3HA mouse splenocytes]
Carcinoma, Lewis Lung
Enhanced thermal stability of lysosomal beta-D-galactosidase in parenchymal cells of tumour bearing mice.
Carcinoma, Papillary
Histochemical demonstration and analysis of poly-N-acetyllactosamine structures in normal and malignant human tissues.
Histochemical demonstration of different types of poly-N-acetyllactosamine structures in human thyroid neoplasms using lectins and endo-beta-galactosidase digestion.
Histochemical differences of the lectin affinities of backbone polylactosamine structures carrying the ABO blood group antigens in papillary carcinoma and other types of thyroid neoplasm.
Simultaneous expression of keratan sulphate epitope (a sulphated poly-N-acetyllactosamine) and blood group ABH antigens in papillary carcinomas of the human thyroid gland.
Carcinoma, Renal Cell
Differential transfection efficiency rates of the GM-CSF gene into human renal cell carcinoma lines by lipofection.
Replication-defective recombinant Semliki Forest virus encoding GM-CSF as a vector system for rapid and facile generation of autologous human tumor cell vaccines.
Suppression of metastasis formation by a recombinant single chain antibody-toxin targeted to full-length and oncogenic variant EGF receptors.
Systemic treatment with a recombinant erbB-2 receptor-specific tumor toxin efficiently reduces pulmonary metastases in mice injected with genetically modified carcinoma cells.
Trypanosoma cruzi infection does not impair major histocompatibility complex class I presentation of antigen to cytotoxic T lymphocytes.
Vaccination Directed against the Human Endogenous Retrovirus-K Envelope Protein Inhibits Tumor Growth in a Murine Model System.
Carcinoma, Squamous Cell
Evaluation of topical gene therapy for head and neck squamous cell carcinoma in an organotypic model.
In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors.
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Receptor-mediated gene delivery using the Fab fragments of anti-epidermal growth factor receptor antibodies: improved immunogene approach.
Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells.
Carcinoma, Transitional Cell
Inhibition of tumorigenicity and metastasis of human bladder cancer growing in athymic mice by interferon-beta gene therapy results partially from various antiangiogenic effects including endothelial cell apoptosis.
Cardiomyopathies
Determinants of the cardiomyopathic phenotype in chimeric mice overexpressing cardiac Gsalpha.
Infantile cardiomyopathy and neuromyopathy with beta-galactosidase deficiency.
Inhibitory G protein overexpression provides physiologically relevant heart rate control in persistent atrial fibrillation.
Three novel beta-galactosidase gene mutations in Han Chinese patients with GM1 gangliosidosis are correlated with disease severity.
Cataract
Variation in glycosidase activity in soluble fractions in ICR/f rat lenses with the progression of cataract formation.
Cell Transformation, Neoplastic
Notch-induced mammary tumorigenesis does not involve the lobule-limited epithelial progenitor.
Central Nervous System Diseases
Generalized CNS disease and massive GM1-ganglioside accumulation in mice defective in lysosomal acid beta-galactosidase.
Cerebellar Ataxia
Adult type GMl-gangliosidosis: a complementation study on somatic cell hybrids.
Localized beta-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry-red spot--a new variant of GM1-gangliosidosis?
Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver.
Neuraminidase in mucolipidoses: normal activity in frozen autopsy tissues from three patients with I-cell disease and adult beta-galactosidase deficiency.
Cerebral Palsy
Beta-galactosidase-deficient mouse as an animal model for GM1-gangliosidosis.
Chagas Disease
Reduction of parasitism tissue by treatment of mice chronically infected with Trypanosoma cruzi with lignano lactones.
Use of recombinant antigens for the accurate immunodiagnosis of Chagas' disease.
Chediak-Higashi Syndrome
Kinetics and mechanism of the bactericidal action of human neutrophils against Escherichia coli.
Chickenpox
Comparative assay of varicella skin test antigens by the ELISA and RPHA tests.
Cholangiocarcinoma
Combined cytosine deaminase expression, 5-fluorocytosine exposure, and radiotherapy increases cytotoxicity to cholangiocarcinoma cells.
Cholangitis
Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss.
Cholera
A secretion expression system using promoter and signal peptide of cholera toxin B subunit gene.
Characterization of ganglioside associated with the thyrotrophin receptor.
CTb targeted non-viral cDNA delivery enhances transgene expression in neurons.
Frontal affinity chromatography-mass spectrometry assay technology for multiple stages of drug discovery: applications of a chromatographic biosensor.
High-affinity lamprey VLRA and VLRB monoclonal antibodies.
Immunostimulatory DNA is a potent mucosal adjuvant.
Priming immunization against cholera toxin and E. coli heat-labile toxin by a cholera toxin short peptide-beta-galactosidase hybrid synthesized in E. coli.
[Biochemical tests for identifying Pasteurella multocida]
Cholestasis
Large liver cell change in hepatitis B virus-related liver cirrhosis.
Cholesteatoma
Catabolism of glycoconjugates in chronic otitis media with cholesteatoma.
Chondrosarcoma
Gene therapy of chondrosarcoma using retrovirus vectors encoding the herpes simplex virus thymidine kinase gene.
Choroidal Effusions
[The role of lysosomal enzymes in the pathogenesis of ciliochoroidal detachment]
Choroidal Neovascularization
Retrovirus-mediated gene transfer to photocoagulation-induced choroidal neovascular membranes.
Cockayne Syndrome
Detection of an involvement of the human mismatch repair genes hMLH1 and hMSH2 in nucleotide excision repair is dependent on UVC fluence to cells.
Enhanced host cell reactivation of a UV-damaged reporter gene in pre-UV-treated cells is delayed in Cockayne syndrome cells.
Increased expression of p53 enhances transcription-coupled repair and global genomic repair of a UVC-damaged reporter gene in human cells.
Coinfection
bcl-2 expression in Spodoptera Frugiperda Sf-9 and Trichoplusia Ni BTI-Tn-5B1-4 insect cells: Effect on recombinant protein expression and cell viability.
Coinfection of Spodoptera exigua and Spodoptera frugiperda cell lines with the nuclear polyhedrosis viruses of Autographa californica and Spodoptera exigua.
Herpes simplex virus 1 (HSV-1) helper co-infection affects the distribution of an amplicon encoded protein in glia.
Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector.
Neural spread of herpes simplex virus after anterior chamber inoculation.
Restoration of a functional open reading frame by homologous recombination between two adenoviral vectors.
The E1 sequence of bovine adenovirus type 3 and complementation of human adenovirus type 5 E1A function in bovine cells.
The induction and kinetics of antigen-specific CD8 T cells are defined by the stage specificity and compartmentalization of the antigen in murine toxoplasmosis.
Transduction of primitive human hematopoietic cells with recombinant adenovirus vectors.
Colitis
Efficient gene delivery to the inflamed colon by local administration of recombinant adenoviruses with normal or modified fibre structure.
Colitis, Ulcerative
Increased transduction of human intestinal epithelial cells by adenoviral vectors in inflammatory bowel disease.
Collagen Diseases
Diagnostic value of determinations of lysosomal hydrolases in CSF of patients with neurological diseases.
Colonic Neoplasms
A new method for determining the status of p53 in tumor cell lines of different origin.
Biodistribution of HuCC49DeltaCH2-beta-galactosidase in colorectal cancer xenograft model.
Combined intratumoral injection of bone marrow-derived dendritic cells and systemic chemotherapy to treat pre-existing murine tumors.
High-level, beta-catenin/TCF-dependent transgene expression in secondary colorectal cancer tissue.
Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells.
Quantitative detection of lac-Z-transfected CC531 colon carcinoma cells in an orthotopic rat liver metastasis model.
Reduced host cell reactivation of oxidative DNA damage in human cells deficient in the mismatch repair gene hMSH2.
Selective suicide gene therapy of colon cancer exploiting the urokinase plasminogen activator receptor promoter.
Src-mediated activation of the human neurotensin/neuromedin N promoter.
Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure.
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins.
The activity of serum beta-galactosidase in colon cancer patients with a history of alcohol and nicotine dependence: preliminary data.
Ursodeoxycholic acid modulates histone acetylation and induces differentiation and senescence.
Colorectal Neoplasms
Chemoembolisation of rat colorectal liver metastases with drug eluting beads loaded with irinotecan or doxorubicin.
E2F-1 overexpression sensitizes colorectal cancer cells to camptothecin.
Growth inhibition of colon cancer cells by transfection of dominant-negative apoptosis signal-regulating kinase-1.
Selective suicide gene therapy of colon cancer exploiting the urokinase plasminogen activator receptor promoter.
Coma
A new integrative reporter plasmid for Streptococcus pneumoniae.
Communicable Diseases
Mineral Analysis, In Vitro Evaluation of Alpha-Amylase, Alpha-Glucosidase, and Beta-Galactosidase Inhibition, and Antibacterial Activities of Juglans regia L. Bark Extracts.
Connective Tissue Diseases
Acid lysosomal hydrolases in systemic sclerosis and other connective tissue diseases.
Corneal Dystrophies, Hereditary
Abnormal product of corneal explants from patients with macular corneal dystrophy.
Corneal Injuries
Blockade of TGF-beta by in vivo gene transfer of a soluble TGF-beta type II receptor in the muscle inhibits corneal opacification, edema and angiogenesis.
Deletion of the FHL2 gene attenuating neovascularization after corneal injury.
Corneal Neovascularization
Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization.
Coronary Occlusion
Enhancement of vascular formation but not improvement of ventricular function of infarcted rat hearts by a high dose of adenovirus-carried VEGF transgene.
Crohn Disease
Fecal beta-D-galactosidase production and Bifidobacteria are decreased in Crohn's disease.
Increased transduction of human intestinal epithelial cells by adenoviral vectors in inflammatory bowel disease.
[Decrease of fecal beta-galactosidase activity in Crohn disease]
Cushing Syndrome
Effects of endogenous hypercortisolism on bone mRNA and microRNA expression in humans.
Cystic Fibrosis
Acid hydrolases in sera and plasma from patients with cystic fibrosis.
Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo.
Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: toxicity study.
Are measurements of urine enzymes useful during aminoglycoside therapy?
Characterization of factors involved in modulating persistence of transgene expression from recombinant adenovirus in the mouse lung.
Clusters of Cl- channels in CFTR-expressing Sf9 cells switch spontaneously between slow and fast gating modes.
Cobalamin R binder as a possible model molecule for glycoprotein study in cystic fibrosis.
Cystic fibrosis transmembrane conductance regulator does not affect neutrophil migration across cystic fibrosis airway epithelial monolayers.
Effect of the E4 region on the persistence of transgene expression from adenovirus vectors.
Efficient gene transfer into myocardium by direct injection of adenovirus vectors.
Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related proteins.
Targeting cell-specific gene expression with an adenovirus vector containing the lacZ gene under the control of the CFTR promoter.
Cystinosis
A study of the low beta-galactosidase activity in cystinotic fibroblasts: effects of cysteamine.
Activities of acid hydrolases in fibroblasts from normal and cystinotic children.
Deficiency Diseases
The specificity of beta-galactosidase in the degradation of gangliosides.
Dehydration
Hypoxia reoxygenation induces premature senescence in neonatal SD rat cardiomyocytes.
Dementia
Cerebrospinal fluid beta-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies.
Leukocyte lysosomal enzymes in Alzheimer's disease and Down's syndrome.
Macular cherry-red spots and myoclonus with dementia: coexistent neuraminidase and beta-galactosidase deficiencies.
Demyelinating Diseases
A model for long-term transgene expression in spinal cord regeneration studies.
Demyelination but no cognitive, motor or behavioral deficits after adenovirus-mediated gene transfer into the brain.
Dengue
Production of the baculovirus-expressed dengue virus glycoprotein NS1 can be improved dramatically with optimised regimes for fed-batch cultures and the addition of the insect moulting hormone, 20-Hydroxyecdysone.
Dental Caries
Impairment of osteocalcin production in senescent periodontal ligament fibroblasts.
Dermatitis, Contact
Adenovirus-mediated blockade of lymphotoxin-beta inhibits the induction of contact sensitivity in mice.
Diabetes Complications
Alterations of glycosaminoglycan metabolism in the development of diabetic complications in relation to metabolic control.
Diabetes Insipidus
The map of chromosome 20.
Diabetes Mellitus
Alterations in the activity of several glycohydrolases in red blood cell membrane from type 2 diabetes mellitus patients.
Alterations of glycosaminoglycan metabolism in the development of diabetic complications in relation to metabolic control.
Association Study between BGLAP Gene HindIII Polymorphism and Type 2 Diabetes Mellitus Development in Ukrainian Population.
Changes in pancreatic lysosomal enzymes activity as the potential factors leading to diabetic enteropathy.
Increased serum alpha-L-fucosidase and beta-N-acetylglucosaminidase activities in diabetic, cirrhotic and gastric cancer patients.
Prospective study of the enzymatic activities in urine of N-acetyl-beta-D-glucosaminidase, alpha-D-mannosidase, alpha- and beta-D-glucosidases, alpha-L- and beta-D-fucosidases, and beta-D-galactosidase in type I diabetes mellitus with early nephropathy.
Urinary acidic glycohydrolases as an index of kidney damage in juvenile diabetes mellitus.
[Activity of lysosomal enzymes in diabetes mellitus patients along with diffuse enlargement of the thyroid gland]
Diabetes Mellitus, Type 1
Hematopoietic stem cell transplantation prevents diabetes in NOD mice but does not contribute to significant islet cell regeneration once disease is established.
Prospective study of the enzymatic activities in urine of N-acetyl-beta-D-glucosaminidase, alpha-D-mannosidase, alpha- and beta-D-glucosidases, alpha-L- and beta-D-fucosidases, and beta-D-galactosidase in type I diabetes mellitus with early nephropathy.
Saliva of patients with Type 1 diabetes: effect of smoking on activity of lysosomal exoglycosidases.
[Study on structural gene expression in human insulinoma]
[Urinary enzymes in insulin-dependent diabetes mellitus]
Diabetes Mellitus, Type 2
Alterations in the activity of several glycohydrolases in red blood cell membrane from type 2 diabetes mellitus patients.
Alterations of glycosaminoglycan metabolism in the development of diabetic complications in relation to metabolic control.
Association Study between BGLAP Gene HindIII Polymorphism and Type 2 Diabetes Mellitus Development in Ukrainian Population.
Diabetic Nephropathies
Prospective study of the enzymatic activities in urine of N-acetyl-beta-D-glucosaminidase, alpha-D-mannosidase, alpha- and beta-D-glucosidases, alpha-L- and beta-D-fucosidases, and beta-D-galactosidase in type I diabetes mellitus with early nephropathy.
[Urinary enzymes in insulin-dependent diabetes mellitus]
Diphtheria
Binding of the metalloregulatory protein DtxR to the diphtheria tox operator requires a divalent heavy metal ion and protects the palindromic sequence from DNase I digestion.
Cell-specific Cre-mediated activation of the diphtheria toxin gene in pituitary tumor cells: potential for cytotoxic gene therapy.
Cell-specific expression of the diphtheria toxin A-chain coding sequence induces cancer cell suicide.
Diphtheria toxin promoter function in Corynebacterium diphtheriae and Escherichia coli.
Genetically engineered diphtheria toxin fusion proteins carrying the hepatitis B surface antigen.
Isolation and characterization of iron-independent positive dominant mutants of the diphtheria toxin repressor DtxR.
Molecular cloning and DNA sequence analysis of a diphtheria tox iron-dependent regulatory element (dtxR) from Corynebacterium diphtheriae.
Molecular cloning, DNA sequence analysis, and characterization of the Corynebacterium diphtheriae dtxR homolog from Brevibacterium lactofermentum.
Naturally-occurring anti-thymocyte autoantibody which identifies a restricted CD4+CD8+CD3-/lo/int thymocyte subpopulation exhibits extensive polyspecificity.
DNA Repair-Deficiency Disorders
Complementation of transformed fibroblasts from patients with combined xeroderma pigmentosum-Cockayne syndrome.
Dwarfism
Morquio-B syndrome (MPS-IV B) associated with beta-galactosidase deficiency in two siblings.
The map of chromosome 20.
Dysostoses
GM1 gangliosidosis and Morquio B disease: expression analysis of missense mutations affecting the catalytic site of acid beta-galactosidase.
Morquio B patient/caregiver survey: First insight into the natural course of a rare GLB1 related condition.
[Juvenile beta-galactosidase deficiency--a case with mental deterioration, dystonic movement, pyramidal symptoms, dysostosis and cherry red spot (author's transl)]
Dystonia
Type 3 GM1 gangliosidosis: characteristic MRI findings correlated with dystonia.
Dystonic Disorders
Elevated beta-N-acetylhexosaminidase activity in focal dystonia fibroblasts.
Ectromelia
Comparative analysis of the conserved region of the orthopoxvirus genome encoding the 36K and 12K proteins.
Fine mechanisms of ectromelia virus thymidine kinase-negative mutants avirulence.
Endocarditis
Enzyme production by lactobacilli and the potential link with infective endocarditis.
Endometrial Neoplasms
The Potential Mechanism of Tiliroside-Dependent Inhibition of t-Butylhydroperoxide-Induced Oxidative Stress in Endometrial Carcinoma Cells.
Endometriosis
Glycosidases in the peritoneal fluid from infertile women with and without endometriosis.
Endotoxemia
Superoxide anion generating capacity and lysosomal enzyme activities of Kupffer cells in galactosamine induced hepatitis.
Enterocolitis, Necrotizing
Endemic necrotizing enterocolitis: lack of association with a specific infectious agent.
Enzootic Bovine Leukosis
Expression in bacteria of beta-galactosidase fusion proteins carrying antigenic determinants of the two X gene products of bovine leukemia virus.
Epilepsies, Myoclonic
Localized beta-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry-red spot--a new variant of GM1-gangliosidosis?
Epilepsy
Localized beta-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry-red spot--a new variant of GM1-gangliosidosis?
Urinary excretion of N-acetyl-beta-glucosaminidase and beta-galactosidase by patients with epilepsy.
Equine Infectious Anemia
Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne muscular dystrophy.
Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice.
Essential Hypertension
[Enzyme activities of beta-hexosaminidase in urine from patients with renal diseases (author's transl)]
exo-alpha-sialidase deficiency
A case of neuraminidase deficiency associated with a partial beta-galactosidase defect. Clinical, biochemical and radiological studies.
A comparative study of sialyloligosaccharides isolated from sialidosis and galactosialidosis urine.
Adult mucolipidosis with beta-galactosidase and neuraminidase deficiencies.
Adult type beta-galactosidase and neuraminidase deficiency in three siblings.
Adult type GMl-gangliosidosis: a complementation study on somatic cell hybrids.
Adult type mucolipidosis with beta-galactosidase and sialidase deficiency. Histological and biochemical studies.
beta-Galactosidase and neuraminidase deficiency associated with angiokeratoma corporis diffusum.
Biochemical comparison of the dysmorphic type with the normosomatic type of sialidosis.
Complementation, cross correction, and drug correction studies of combined beta-galactosidase neuraminidase deficiency in human fibroblasts.
Elastogenesis in cultured dermal fibroblasts from patients with lysosomal beta-galactosidase, protective protein/cathepsin A and neuraminidase-1 deficiencies.
Electrophysiological studies of myoclonus in sialidosis type 2.
Enhanced proteolytic degradation of normal beta-galactosidase in the lysosomal storage disease with combined beta-galactosidase and neuraminidase deficiency.
Galactosialidosis: molecular heterogeneity among distinct clinical phenotypes.
Human beta-galactosidase and alpha-neuraminidase deficient mucolipidosis: genetic complementation analysis of the neuraminidase deficiency.
Km defect in neuraminidase of dysmorphic type sialidosis with and without beta-galactosidase deficiency.
Lysosomal sialidase deficiency in sialidosis with partial beta-galactosidase deficiency.
Molecular defect in combined beta-galactosidase and neuraminidase deficiency in man.
Molecular heterogeneity in human beta-galactosidase and neuraminidase deficiency.
Neuraminidase deficiency and accumulation of sialic acid in lymphocytes in adult type sialidosis with partial beta-galactosidase deficiency.
Neuropathological findings of an autopsy case of adult beta-galactosidase and neuraminidase deficiency.
Turnover of beta-galactosidase in fibroblasts from patients with genetically different types of beta-galactosidase deficiency.
Ultrastructural and immunocytochemical study of skin fibroblasts from normal and sialidosis patients.
[Adult type beta-galactosidase and neuraminidase deficiency in 3 siblings]
[Skin and conjunctival biopsies in adult type beta-galactosidase neuraminidase deficiency]
Extranodal Extension
Gene therapy of metastatic cancer by in vivo retroviral gene targeting.
Eye Diseases
Antibodies reactive with an intracellular epitope of a recombinant 64 kDa thyroid and eye muscle protein in patients with thyroid autoimmunity and ophthalmopathy.
Fabry Disease
Angiokeratoma corporis diffusum in GM1 gangliosidosis, type 1.
beta-Galactosidase and neuraminidase deficiency associated with angiokeratoma corporis diffusum.
beta-Galactosidase deficiency: An approach to chaperone therapy.
Fibroblast alpha-galactosidase A activity for identification of Fabry's disease heterozygotes.
Heterozygote detection in Fabry disease utilizing multiple enzyme activities.
[Wolman disease, Fabry disease and beta-galactosidase deficiency]
Facial Nerve Injuries
Adenoviral vector-mediated GDNF gene transfer prevents death of adult facial motoneurons.
Fanconi Anemia
Persistent low-level engraftment of rhesus peripheral blood progenitor cells transduced with the fanconi anemia C gene after conditioning with low-dose irradiation.
Fanconi Syndrome
Coordinately increased lysozymuria and lysosomal enzymuria induced by maleic acid.
Fibrosarcoma
Delayed reactivation of p53 in the progeny of cells surviving ionizing radiation.
Gene therapy for sarcoma utilizing adenoviral transfer of the beta-glucuronidase and bax genes and an anthracyline prodrug.
Gene transfer in dendritic cells, induced by oral DNA vaccination with Salmonella typhimurium, results in protective immunity against a murine fibrosarcoma.
In vivo marking of spontaneous or vaccine-induced fibrosarcomas in the domestic house cat, using an adenoviral vector containing a bifunctional fusion protein, GAL-TEK.
Isolated limb perfusion in the sarcoma-bearing rat: a novel preclinical gene delivery system.
Modulation of host immune responses stimulated by Salmonella vaccine carrier strains by using different promoters to drive the expression of the recombinant antigen.
Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence.
Salmonella vaccine carrier strains: effective delivery system to trigger anti-tumor immunity by oral route.
The defined attenuated Listeria monocytogenes delta mp12 mutant is an effective oral vaccine carrier to trigger a long-lasting immune response against a mouse fibrosarcoma.
Tumor-specific gene delivery mediated by a novel peptide-polyethylenimine-DNA polyplex targeting aminopeptidase N/CD13.
Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells.
Filariasis
Heat shock cognate 70 is a prominent immunogen in Brugian filariasis.
Fluorosis, Dental
Evaluating the Association Between Dental Fluorosis and Polymorphisms in Bone Development and Mineralization Genes Among Population from a Fluoride Endemic Region of Eastern India.
Foot-and-Mouth Disease
Antigenicity of a viral peptide displayed on beta-galactosidase fusion proteins is influenced by the presence of the homologous partner protein.
Bacterially expressed antigenic peptide from foot-and-mouth disease virus capsid elicits variable immunologic responses in animals.
Beta-galactosidase enzymatic activity as a molecular probe to detect specific antibodies.
Biosensor characterization of antigenic site A of foot-and-mouth disease virus presented in different vector systems.
Comparison of immune responses against foot-and-mouth disease virus induced by fusion proteins using the swine IgG heavy chain constant region or beta-galactosidase as a carrier of immunogenic epitopes.
Discriminating foot-and-mouth disease virus-infected and vaccinated animals by use of beta-galactosidase allosteric biosensors.
Fusion proteins with multiple copies of the major antigenic determinant of foot-and-mouth disease virus protect both the natural host and laboratory animals.
High-titer bicistronic retroviral vectors employing foot-and-mouth disease virus internal ribosome entry site.
Improved mimicry of a foot-and-mouth disease virus antigenic site by a viral peptide displayed on beta-galactosidase surface.
Noncytopathic flavivirus replicon RNA-based system for expression and delivery of heterologous genes.
OmpA fusion proteins for presentation of foreign antigens on the bacterial outer membrane.
Recombinant fusion protein and DNA vaccines against foot and mouth disease virus infection in guinea pig and swine.
Successful mimicry of a complex viral antigen by multiple peptide insertions in a carrier protein.
The position of the heterologous domain can influence the solubility and proteolysis of beta-galactosidase fusion proteins in E. coli.
Uses of beta-galactosidase tag in on-line monitoring production of fusion proteins and gene expression in Escherichia coli.
[Recombinant plasmids containing hybrid protein genes with antigenic determinants of the foot and mouth virus]
Fowlpox
A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virus.
Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor-associated antigen.
Construction of fowlpox virus vectors with intergenic insertions: expression of the beta-galactosidase gene and the measles virus fusion gene.
Quantitative assessment of poxvirus promoters in fowlpox and vaccinia virus recombinants.
Friedreich Ataxia
Lysosomal enzymes in ataxia: discovery of two new cases of late onset hexosaminidase A and B deficiency (adult Sandhoff disease) in French Canadians.
Fucosidosis
Fucosidosis in a native-born Briton.
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs.
galactosylceramidase deficiency
Paradoxical influence of acid beta-galactosidase gene dosage on phenotype of the twitcher mouse (genetic galactosylceramidase deficiency).
Ganglion Cysts
A herpes simplex virus type 1 vector as marker for retrograde neuronal tracing: characterization of lacZ transcription and localization of labelled neuronal cells in sensory and autonomic ganglia after inoculation of the anterior segment of the eye.
Gangliosidoses
A benign deficiency of typeB beta-galactosidase in human liver.
Beta-galactosidase in tissue culture derived from human skin and bone marrow. Enzyme defect in GM1 gangliosidosis.
Complementation, cross correction, and drug correction studies of combined beta-galactosidase neuraminidase deficiency in human fibroblasts.
GM1 gangliosidosis (type 1) in a cat.
GM1 gangliosidosis: review of clinical, molecular, and therapeutic aspects.
Hepatic beta galactosidase and feline GMI gangliosidosis.
Inactivation of GM1-ganglioside beta-galactosidase by a specific inhibitor: a model for ganglioside storage disease.
Infantile G(M1) gangliosidosis: complete morphology and histochemistry of two autopsy cases, with particular reference to delayed central nervous system myelination.
Leukocyte beta-galactosidase activity in the diagnosis of generalized GM 1 gangliosidosis.
Mutations in the lysosomal beta-galactosidase gene that cause the adult form of GM1 gangliosidosis.
Structure of the glycopeptide storage material in GM 1 gangliosidosis. Sequence determination with specific endo- and exoglycosidases.
Substrate reduction reduces gangliosides in postnatal cerebrum-brainstem and cerebellum in GM1 gangliosidosis mice.
Gangliosidoses, GM2
Morphology of the gangliosidoses.
Gangliosidosis, GM1
A benign deficiency of typeB beta-galactosidase in human liver.
A beta-galactosidase gene mutation identified in both Morquio B disease and infantile GM1 gangliosidosis.
A common mutation site in the beta-galactosidase gene originates in Puerto Rico.
A comparative study of sialyloligosaccharides isolated from sialidosis and galactosialidosis urine.
A family with beta-galactosidase deficiency: three adults with atypical clinical patterns.
A fluorimetric enzyme assay for the diagnosis of Morquio disease type A (MPS IV A).
A microassay for acid beta-galactosidase activity toward asialofetuin.
A quantitative cytochemical assay of beta-galactosidase in single cultured human skin fibroblasts.
A simple method of lysosomal hydrolase assay in a single somatic cell and its application.
A Single Injection of an Optimized Adeno-Associated Viral Vector into Cerebrospinal Fluid Corrects Neurological Disease in a Murine Model of GM1 Gangliosidosis.
A spreadable, non-integrative and high copy number shuttle vector for Sulfolobus solfataricus based on the genetic element pSSVx from Sulfolobus islandicus.
A two-year-old patient with an atypical expression of GM1-beta-galactosidase deficiency: biochemical, immunological, and cell genetic studies.
Adrenoleukodystrophy and beta-galactosidase deficiency: patient and carrier.
Adult GM1 gangliosidosis: clinical and biochemical studies on two patients and comparison to other patients called variant or adult GM1 gangliosidosis.
An electrophoretic variant of beta-galactosidase with altered catalytic properties in a patient with GM1 gangliosidosis.
Application of epithelial cells in culture to the biochemical studies of lysosomal hydrolase deficiencies.
Atypical adult GM1 gangliosidosis: biochemical comparison with other forms of primary beta-galactosidase deficiency.
Atypical expression of beta-galactosidase deficiency in a child with Hurler-like features but without neurological abnormalities.
Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis.
Beta-D-galactosidase in human urine: deficiency in generalized gangliosidosis.
Beta-galactosidase deficiencies and novel GLB1 mutations in three Chinese patients with Morquio B disease or GM1 gangliosidosis.
Beta-galactosidase deficiency in a Korat cat: a new form of feline GM1-gangliosidosis.
beta-Galactosidase deficiency in an adult: a biochemical and somatic cell genetic study on a variant of GM1-gangliosidosis.
Beta-galactosidase deficiency in GM1 gangliosidosis of Friesian calves.
beta-Galactosidase deficiency in juvenile and adult patients. Report of six Japanese cases and review of literature.
Beta-galactosidase deficiency in the hurler syndrome.
beta-Galactosidase deficiency: An approach to chaperone therapy.
Beta-galactosidase deficiency: prolonged survival in three patients following early central nervous system deterioration.
Beta-galactosidase deficiency: studies of two patients with prolonged survival.
beta-Galactosidase gene mutations in patients with slowly progressive GM1 gangliosidosis.
Beta-galactosidase in tissue culture derived from human skin and bone marrow. Enzyme defect in GM1 gangliosidosis.
Beta-galactosidase-deficient mouse as an animal model for GM1-gangliosidosis.
Biochemical comparison of the dysmorphic type with the normosomatic type of sialidosis.
Biochemical, immunological, and structural studies on a sphingolipid activator protein (SAP-1).
Biosynthesis of the sulfatide/GM1 activator protein (SAP-1) in control and mutant cultured skin fibroblasts.
Brain beta-galactosidase and gm1 gangliosidosis.
Canine GM1 gangliosidosis. An ultrastructural and biochemical study.
Cardiac involvement in diseases characterized by beta-galactosidase deficiency.
Carrier detection of sialidosis with partial beta-galactosidase deficiency by the assay of lysosomal sialidase in lymphocytes.
Cerebrospinal fluid biomarkers showing neurodegeneration in dogs with GM1 gangliosidosis: possible use for assessment of a therapeutic regimen.
Chaperone therapy for neuronopathic lysosomal diseases: competitive inhibitors as chemical chaperones for enhancement of mutant enzyme activities.
Characterization of beta-galactosidase in leukocytes and fibroblasts of GM1 gangliosidosis heterozygotes compared to normal subjects.
Characterization of beta-galactosidase mutations Asp332-->Asn and Arg148-->Ser, and a polymorphism, Ser532-->Gly, in a case of GM1 gangliosidosis.
Chemical pathology of krabbe's disease. IV. Studies of galactosylceramide and lactosylceramide BETA-galactosidases in brain, white blood cells and aminotic fluid cells.
Chronic GM1 gangliosidosis presenting as dystonia: I. Clinical and pathological features.
Clinical and clinico-pathologic characteristics of Shiba dogs with a deficiency of lysosomal acid beta-galactosidase: a canine model of human GM1 gangliosidosis.
Clinical and molecular heterogeneity in hereditary beta-galactosidase deficiency.
Clinical features of adult GM1 gangliosidosis: report of three Indian patients and review of 40 cases.
Combined sialidase (neuraminidase) and beta-galactosidase deficiency. Clinical, morphological and enzymological observations in a patient.
Complementation analysis of beta-galactosidase deficiency by means of histochemical method.
Complementation studies with enucleated fibroblasts from different variants of beta-galactosidase deficiency.
Corneal clouding in GM1-generalized gangliosidosis.
Correction of accumulation of sulfate-containing compounds in cultured generalized gangliosidosis fibroblasts by beta-galactosidase.
Correction of acid beta-galactosidase deficiency in GM1 gangliosidosis human fibroblasts by retrovirus vector-mediated gene transfer: higher efficiency of release and cross-correction by the murine enzyme.
Detection of acid-beta-galactosidase activity in viable human fibroblasts by flow cytometry.
Development and medical application of unsaturated carbaglycosylamine glycosidase inhibitors.
Diagnosis of feline GM1 gangliosidosis by enzyme assay of cultured conjunctival cells.
Diagnosis of subtypes of GM1 gangliosidosis in vitro and in vivo--using urinary oligosaccharides as substrates.
Diagnosis of unsuspected fetal metabolic storage disease by routine placental examination.
Disentangling molecular and clinical stratification patterns in beta-galactosidase deficiency.
Dog and human acid beta-D-galactosidases are structurally similar.
Dog GM1 gangliosidosis: characterization of the residual liver acid beta-galactosidase.
Dystonia and parkinsonism in GM1 type 3 gangliosidosis.
Effect of bile salts on lactosylceramide beta-galactosidase activities in human brain, liver and cultured skin fibroblasts.
Effects of exogenous beta-galactosidase on cultured fibroblasts with beta-galactosidase deficiency.
Effects of thiol protease inhibitors on intracellular degradation of exogenous beta-galactosidase in cultured human skin fibroblasts.
Expression and characterization of 14 GLB1 mutant alleles found in GM1-gangliosidosis and Morquio B patients.
Expression of beta-galactosidase in preimplantation ovine and porcine embryos.
Feline GM1 gangliosidosis: characterization of the residual liver acid beta-galactosidase.
Fibroblast screening for chaperone therapy in beta-galactosidosis.
Fine structure of meganeurites and secondary growth processes in feline GM1-gangliosidosis.
Four novel mutations in patients from the Middle East with the infantile form of GM1-gangliosidosis.
Ganglioside GM1 metabolism in living human fibroblasts with beta-galactosidase deficiency.
Gene transfer to human cells: transducing phage lambda plac gene expression in GMI-gangliosidosis fibroblasts.
Generalized gangliosidosis: acid beta-galactosidase deficiency with early onset, rapid mental deterioration and minimal bone dysplasia.
Generalized gangliosidosis: beta-galactosidase deficiency.
Generation and characterization of recombinant feline beta-galactosidase for preclinical enzyme replacement therapy studies in GM1 gangliosidosis.
GM1 gangliosidosis and Morquio B disease: an update on genetic alterations and clinical findings.
GM1 gangliosidosis and Morquio B disease: expression analysis of missense mutations affecting the catalytic site of acid beta-galactosidase.
GM1 gangliosidosis in adults: clinical and molecular analysis of 16 Japanese patients.
GM1 gangliosidosis in shiba dogs.
GM1 gangliosidosis type 2 in two siblings.
GM1 gangliosidosis: clinical and laboratory findings in eight families.
GM1 gangliosidosis: enzymatic variation in a single family.
GM1 gangliosidosis: phenotypic variation in a single family.
GM1-ganglioside accumulation and beta-galactosidase deficiency in a case of GM1-gangliosidosis (Landing disease).
GM1-gangliosidosis in Alaskan huskies: clinical and pathologic findings.
Human leukocyte and plasma beta-D-fucosidase: identity with beta-D-galactosidase.
Hunter's syndrome: beta-galactosidase deficiency in skin.
Hydrolysis of galactosylsphingosine and lactosylsphingosine by beta-galactosidases in human brain and cultured fibroblasts.
Hyperphosphatasemia in early diagnosed infantile GM1 gangliosidosis presenting as transient hydrops fetalis.
Identification of 14 novel GLB1 mutations, including five deletions, in 19 patients with GM1 gangliosidosis from South America.
Identification of a novel pseudodeficiency allele in the GLB1 gene in a carrier of GM1 gangliosidosis.
Immunological studies of beta galactosidase in normal human liver and in GM1 gangliosidosis.
Incorporation and degradation of GM1 ganglioside and asialoGM1 ganglioside in cultured fibroblasts from normal individuals and patients with beta-galactosidase deficiency.
Infantile cardiomyopathy and neuromyopathy with beta-galactosidase deficiency.
Infantile G(M1) gangliosidosis: complete morphology and histochemistry of two autopsy cases, with particular reference to delayed central nervous system myelination.
Inheritance of lysosomal acid beta-galactosidase activity and gangliosides in crosses of DBA/2J and knockout mice.
Inherited lysosomal storage disease associated with deficiencies of beta-galactosidase and alpha-neuraminidase in sheep.
Intergenic complementation after fusion of fibroblasts from different patients with beta-galactosidase deficiency.
Interspecific genetic complementation analysis of human and sheep fibroblasts with beta-galactosidase deficiency.
Intracellular processing and maturation of mutant gene products in hereditary beta-galactosidase deficiency (beta-galactosidosis).
Intracerebroventricular enzyme replacement therapy with Beta-Galactosidase reverses brain pathologies due to GM1 gangliosidosis in mice.
Isolation and characterization of major urinary oligosaccharides excreted by a patient with type 3 GM1 gangliosidosis.
Juvenile GM1 gangliosidosis. Occurrence with absence of two beta-galactosidase components.
Km defect in neuraminidase of dysmorphic type sialidosis with and without beta-galactosidase deficiency.
Landing disease, GM1 generalized gangliosidosis, and malabsorption syndrome.
Letter: Beta-galactosidase deficiency in young adults.
Leukocyte beta-galactosidase activity in the diagnosis of bovine GM1 gangliosidosis.
Localized beta-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry-red spot--a new variant of GM1-gangliosidosis?
Lymphoblastoid cell lines, transformed by Epstein-Barr virus, in the enzymatic study of hereditary lysosomal storage diseases.
Lysosomal enzyme activities among Chinese: leukocyte alpha-galactosidase and beta-galactosidase.
Lysosomal sialidase deficiency in sialidosis with partial beta-galactosidase deficiency.
Lysosomal storage diseases presenting as transient or persistent hydrops fetalis.
Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver.
Magnetic resonance imaging findings and novel mutations in GM1 gangliosidosis.
Manifestation of infantile GM1 gangliosidosis in the fetal eye. An electron microscopic study.
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs.
Meganeurites and other aberrant processes of neurons in feline GM1-gangliosidosis: a Golgi study.
Molecular basis of GM1 gangliosidosis and Morquio disease, type B. Structure-function studies of lysosomal beta-galactosidase and the non-lysosomal beta-galactosidase-like protein.
Molecular consequences of the pathogenic mutation in feline GM1 gangliosidosis.
Molecular form and subcellular distribution of acid beta-galactosidase in fibroblasts from patients with GM1 gangliosidosis, Morquio B disease and galactosialidosis.
Morphological analysis of corneal opacity in Shiba dog with GM1 gangliosidosis.
Morquio syndrome (mucopolysaccharidosis IV B) associated with beta-galactosidase deficiency. Report of two cases.
Morquio's disease type B (beta-galactosidase deficiency) in three siblings.
Morquio-B disease, spondyloepiphyseal dysplasia associated with acid beta-galactosidase deficiency. Report of three cases in one family.
Morquio-B syndrome (MPS-IV B) associated with beta-galactosidase deficiency in two siblings.
Morquio-like syndrome with beta galactosidase deficiency and normal hexosamine sulfatase activity: mucopolysacchariodosis IVB.
Multiple carbohydrate-cleaving specificities in human acidic and neutral glycosidases.
Mutation analyses in 17 patients with deficiency in acid beta-galactosidase: three novel point mutations and high correlation of mutation W273L with Morquio disease type B.
Mutations in the lysosomal beta-galactosidase gene that cause the adult form of GM1 gangliosidosis.
Myelination arrest demonstrated using magnetic resonance imaging in a child with type I GM1 gangliosidosis.
N-butyldeoxygalactonojirimycin reduces neonatal brain ganglioside content in a mouse model of GM1 gangliosidosis.
Neuraminidase deficiency and accumulation of sialic acid in lymphocytes in adult type sialidosis with partial beta-galactosidase deficiency.
Neuraminidase in mucolipidoses: normal activity in frozen autopsy tissues from three patients with I-cell disease and adult beta-galactosidase deficiency.
Neurochemical abnormality in I-cell disease: chemical analysis and a possible importance of beta-galactosidase deficiency.
Neuroimaging findings in infantile GM1 gangliosidosis.
Neurological manifestations of knockout mice with beta-galactosidase deficiency.
Neuronal GM1 gangliosidosis in a Siamese cat with beta-galactosidase deficiency.
Neuronal-visceral GM1 gangliosidosis in a dog with beta-galactosidase deficiency.
Neuronal-visceral GM1 gangliosidosis in Portuguese water dogs.
Neurovisceral and skeletal GM1-gangliosidosis in dogs with beta-galactosidase deficiency.
Normal serum beta-galactosidase in juvenile GM1 gangliosidosis.
Novel mutations (Asn 484 Lys, Thr 500 Ala, Gly 438 Glu) in Morquio B disease.
Paradoxical influence of acid beta-galactosidase gene dosage on phenotype of the twitcher mouse (genetic galactosylceramidase deficiency).
Partial characterization and studies of fibroblast and leucocyte neuraminidase activities towards sialyloligosaccharides in adult sialidosis and mucolipidosis II and III.
Pattern of beta-galactosidase deficiency in GM1-gangliosidosis type 1 and type 2.
Population analysis of the GLB1 gene in South Brazil.
Prenatal diagnosis of sialidosis with combined neuraminidase and beta-galactosidase deficiency.
Presence of glycoproteins containing the polylactosamine structure in brain and liver of GM1 gangliosidosis patients. Comparative study between clinical types I and II, using endo-beta-galactosidase enzyme.
Primary and secondary elastin-binding protein defect leads to impaired elastogenesis in fibroblasts from GM1-gangliosidosis patients.
Processing of human beta-galactosidase in GM1-gangliosidosis and Morquio B syndrome.
Processing of lysosomal beta-galactosidase. The C-terminal precursor fragment is an essential domain of the mature enzyme.
Purification and characterization of human liver beta-galactosidase from a patient with the adult form of GM1 gangliosidosis and a normal control.
Quantitation of the enzymically deficient cross reacting material in GM1 gangliosidoses.
Recent advances in Dyggve-Melchior-Clausen syndrome.
Report of an infant with GM1 gangliosidosis type I and extensive and unusual mongolian spots.
Selective noncompetitive assimilation of bovine testicular beta-galactosidase and bovine liver beta-glucuronidase by generalized gangliosidosis fibroblasts.
Simple laboratory determination of excess oligosacchariduria.
Spondyloepiphyseal dysplasia, corneal clouding, normal intelligence and acid beta-galactosidase deficiency.
Structural bases of GM1 gangliosidosis and Morquio B disease.
The Arg482His mutation in the beta-galactosidase gene is responsible for a high frequency of GM1 gangliosidosis carriers in a Cypriot village.
The complementation of beta-galactosidase in fused cells of mucolipidosis II with another variants of beta-galactosidase deficiency using new single cell enzyme assay.
The genetic defect in the various types of human beta-galactosidase deficiency.
The role of glycosidically bound mannose in the assimilation of beta-galactosidase by generalized gangliosidosis fibroblasts.
The role of lysosomal sialidase and beta-galactosidase in processing the complex carbohydrate chains on lysosomal enzymes and possibly other glycoproteins.
The specificity of beta-galactosidase in the degradation of gangliosides.
The use of tears for diagnosis of GM1 gangliosidosis.
Three cases of beta-galactosidase deficiency.
Three GM1-gangliosidoses and a variant of beta-galactosidase deficiency.
Three novel beta-galactosidase gene mutations in Han Chinese patients with GM1 gangliosidosis are correlated with disease severity.
Transient high-level expression of beta-galactosidase after transfection of fibroblasts from GM1 gangliosidosis patients with plasmid DNA.
Turnover of beta-galactosidase in fibroblasts from patients with genetically different types of beta-galactosidase deficiency.
Twenty-one novel mutations in the GLB1 gene identified in a large group of GM1-gangliosidosis and Morquio B patients: possible common origin for the prevalent p.R59H mutation among gypsies.
Type 1 GM1 gangliosidosis with basal ganglia calcification: a case report.
Type 2 GM1 gangliosidosis with long survival and neuronal ceroid lipofuscinosis.
Type 3 (adult) GM1 gangliosidosis: case report.
Type 3 (chronic) GM1 gangliosidosis presenting as infanto-choreo-athetotic dementia, without epilepsy, in three sisters.
Type III (chronic) GM1-gangliosidosis. Histochemical and ultrastructural studies of rectal biopsy.
Ultrastructural lesions of ovine GM1 gangliosidosis.
Urinary oligosaccharide screening in patients with beta-galactosidase deficiency.
Variability of bacterial gene-directed enzyme production in human genetically deficient cells.
Variable clinical presentation in lysosomal storage disorders.
[A case of adult type sialidosis with partial beta-galactosidase deficiency without myoclonus]
[Adult mucolipidosis with beta-galactosidase deficiency: a clinical report, with studies of urinary sialic acid-rich substances (author's transl)]
[Beta-galactosidase deficiency in the small intestine and its enzyme therapy]
[Beta-galactosidase deficiency]
[beta-Galactosidosis (acid beta-galactosidase deficiency: GM1 gangliosidosis, Morquio B disease)]
[beta-galactosidosis--GM1 gangliosidosis and Morquio B disease]
[Clinical, ultrastructural and biochemical study of a case of GM1 type 2 gangliosidosis]
[Gangliosidosis GM1. Clinical, radiologic, biochemical and histological studies in two cases (author's transl)]
[Lysosomal beta-galactosidase properties and the molecular genetics of GM1 gangliosidosis]
[Molecular genetics of beta-galactosidase deficiency (GM1-gangliosidosis and Morquio syndrome type B)]
[Molecular pathology of neurogenetic diseases]
[Morquio syndrome moderated by beta galactosidase deficiency. Mucopolysaccharidosis (type IV B) or oligosaccharidosis]
[Morquio syndrome, beta-galactosidase deficiency]
[The metabolism of radiolabelled GM1-ganglioside in cultured skin fibroblasts from controls and patients with GM1-gangliosidosis]
[The role of ophthalmological examination in the diagnosis of gangliosidosis GM1].
[Two siblings of type 3 GM1 gangliosidosis with different clinical features and different ages of onset]
[Wolman disease, Fabry disease and beta-galactosidase deficiency]
Gastritis
Requirements for autoimmune responses to mouse gastric autoantigens.
Gastroenteritis
Comparison of enzyme-linked immunosorbent assay, electron microscopy, and reversed passive haemagglutination for detection of human rotavirus in stool specimens.
Expression of porcine transmissible gastroenteritis virus genes in E. coli as beta-galactosidase chimaeric proteins.
Gastroenteritis, Transmissible, of Swine
Expression of porcine transmissible gastroenteritis virus genes in E. coli as beta-galactosidase chimaeric proteins.
Gaucher Disease
Acid hydrolases in serum from patients with lysosomal disorders.
Identity of beta-glucosidase, beta-xylosidase and one of the beta-galactosidase activities in human liver when assayed with 4-methylumbelliferyl-beta-D-glycosides studies in cases of Gaucher's disease.
Lymphoblastoid cell lines, transformed by Epstein-Barr virus, in the enzymatic study of hereditary lysosomal storage diseases.
Multiple carbohydrate-cleaving specificities in human acidic and neutral glycosidases.
Variable clinical presentation in lysosomal storage disorders.
Genetic Diseases, Inborn
Characterization of human lysosomal neuraminidase defines the molecular basis of the metabolic storage disorder sialidosis.
GM1 gangliosidosis: clinical and laboratory findings in eight families.
Normal serum beta-galactosidase in juvenile GM1 gangliosidosis.
Substrate specificities of the two genetically distinct human brain beta-galactosidases.
Giant Cell Tumors
Modulation of osteoclast function by adenovirus vector-induced epidermal growth factor receptor.
Glioblastoma
A glial-specific, repressible, adenovirus vector for brain tumor gene therapy.
Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma.
Increased activity of lysosomal glycohydrolases in glioma tissue and surrounding areas from human brain.
Integration of active human beta-galactosidase gene (100 kb) into genome using HSV/AAV amplicon vector.
Invasive pattern of lac-Z-transfected human glioblastoma cells in nude mice brain.
Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms.
[Gene transduction for experimental brain tumors using recombinant adenovirus vector]
Glioma
A glycosylated nitric oxide donor, beta-Gal-NONOate, and its site-specific antitumor activity.
Activity of lysosomal exoglycosidases in human gliomas.
Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma.
Adenoviral-mediated gene transfer into the canine brain in vivo.
Adenovirus-mediated p53 gene delivery inhibits 9L glioma growth in rats.
Antitumor effect and cellular immunity activation by murine interferon-beta gene transfer against intracerebral glioma in mouse.
Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses.
Combined antitumor effects of an adenoviral cytosine deaminase/thymidine kinase fusion gene in rat C6 glioma.
Combined radiation and p53 gene therapy of malignant glioma cells.
Conditional gene expression in human intracranial xenograft tumors.
Diffuse brain invasion of glioma cells requires beta 1 integrins.
Efficient retrovirus-mediated cytokine-gene transduction of primary-cultured human glioma cells for tumor vaccination therapy.
Endothelial cell implantation and survival within experimental gliomas.
Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line.
Gene therapy for malignant glioma using Sindbis vectors expressing a fusogenic membrane glycoprotein.
Glioma-associated endothelial cells show evidence of replicative senescence.
Glypican and biglycan in the nuclei of neurons and glioma cells: presence of functional nuclear localization signals and dynamic changes in glypican during the cell cycle.
Growth related changes in sugar determinants on the surface of C6 glioma cells in culture: a cytochemical lectin-binding study.
Improved lipid-mediated gene transfer in C6 glioma cells and primary glial cells using FuGene.
Inactivation of GM1-ganglioside beta-galactosidase by a specific inhibitor: a model for ganglioside storage disease.
Intracerebral adenovirus-mediated p53 tumor suppressor gene therapy for experimental human glioma.
Lipid-mediated gene transfer into primary neurons using FuGene: comparison to C6 glioma cells and primary glia.
Liposome-mediated gene transfer into established CNS cell lines, primary glial cells, and in vivo.
Lysosomal isozyme patterns in ethylnitrosourea-induced brain tumors.
Migration of genetically labeled glioma cells after implantation into murine brain.
Migratory patterns of lac-z transfected human glioma cells in the rat brain.
Repeated exposure to cationic immunoliposomes activates effective gene transfer to human glioma cells.
Retrovirus-mediated gene transfer targeted to malignant glioma cells in murine brain.
Selective expression of foreign genes in glioma cells: use of the mouse myelin basic protein gene promoter to direct toxic gene expression.
Stereotactic delivery of a recombinant adenovirus into a C6 glioma cell line in a rat brain tumor model.
Structure and expression of rat S-100 beta subunit gene.
The Histone Demethylase Jumonji Coordinates Cellular Senescence Including Secretion of Neural Stem Cell-attracting Cytokines.
The lac-z reporter gene: a tool for in vitro studies of malignant glioma cell invasion.
Transfection of a vector expressing wild-type p53 into cells of two human glioma cell lines enhances radiation toxicity.
Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the Egr-1 promoter: activation by ionizing radiation or uptake of radioactive iododeoxyuridine.
Gliosarcoma
Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy.
Photoacoustic imaging of lacZ gene expression in vivo.
Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the Egr-1 promoter: activation by ionizing radiation or uptake of radioactive iododeoxyuridine.
[Gene transduction for experimental brain tumors using recombinant adenovirus vector]
Glomerulonephritis
Changes in lysosome populations in the rat kidney cortex induced by passive Heymann glomerulonephritis.
Comparison of the urinary excretion of aspartate aminotransferase, lactic dehydrogenase, alkaline and acid phosphatases and beta-galactosidase during nephrotoxic serum glomerulonephritis and mercuric chloride tubulonephritis in the rat.
Urinary glycosaminoglycans, sialic acid and lysosomal enzymes increase in nonalbuminuric diabetic patients.
[Clinical significance of enzymuria in glomerulonephritis in children]
Glycogen Storage Disease Type II
Expression of lysosomal enzymes in human mutant fibroblast-chick erythrocyte heterokaryons.
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs.
Glycosuria
Acid glycohydrolase in Chinese hamster with spontaneous diabetes. I. Depressed levels of renal alpha-galactosidase and beta-galactosidase.
Granuloma
Histoenzymology of the lung. II. The behaviour of lung hydrolytic enzymes during some experimental pulmonary processes.
The substance P receptor is necessary for a normal granulomatous response in murine schistosomiasis mansoni.
[Lysosomal enzymes of phagocytizing cells in the pathogenesis of inflammation]
Graves Disease
Antibodies reactive with an intracellular epitope of a recombinant 64 kDa thyroid and eye muscle protein in patients with thyroid autoimmunity and ophthalmopathy.
Serum lysosomal acid hydrolase activities in Graves' disease.
Graves Ophthalmopathy
Antibodies reactive with an intracellular epitope of a recombinant 64 kDa thyroid and eye muscle protein in patients with thyroid autoimmunity and ophthalmopathy.
Head and Neck Neoplasms
Silk-elastinlike protein polymer hydrogels for localized adenoviral gene therapy of head and neck tumors.
Head Injuries, Penetrating
Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: in vivo comparison of distinct GFAP-lacZ transgenes.
Heart Failure
Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure.
Improved exercise capacity and reduced systemic inflammation after adenoviral-mediated SERCA-2a gene transfer.
Targeting phospholamban by gene transfer in human heart failure.
Helicobacter Infections
NF-kappaB activation during acute Helicobacter pylori infection in mice.
Hemorrhagic Fever with Renal Syndrome
Cloning and sequencing of Puumala virus Sotkamo strain S and M RNA segments: evidence for strain variation in hantaviruses and expression of the nucleocapsid protein.
Hepatitis
Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus.
Bile ductular cell reaction with senescent hepatocytes in chronic viral hepatitis is lost during hepatocarcinogenesis.
Molecular cloning of hepatitis delta virus RNA from an infected woodchuck liver: sequence, structure, and applications.
Serum beta-N-acetylglucosaminidase, beta-D-glucosidase, alpha-D-glucosidase, beta-D-fucosidase, alpha-L-fucosidase and beta-D-galactosidase levels in acute viral hepatitis, pancreatitis, myocardial infarction and breast cancer.
Hepatitis A
Autoproteolytic cleavage of recombinant 3C proteinase of hepatitis A virus.
Characterization of hepatitis A virus capsid proteins with antisera raised to recombinant antigens.
Membrane permeability induced by hepatitis A virus proteins 2B and 2BC and proteolytic processing of HAV 2BC.
Hepatitis B
Construction and application of plasmids containing bidirectional promoters of vaccinia virus.
Direct gene transfer to the liver with herpes simplex virus type 1 vectors: transient production of physiologically relevant levels of circulating factor IX.
Dominant negative mutants of the duck hepatitis B virus core protein interfere with RNA pregenome packaging and viral DNA synthesis.
Effect of the N-terminal hydrophobic sequence of hepatitis B virus surface antigen on the folding and assembly of hybrid beta-galactosidase in Escherichia coli.
Efficient in vivo transduction of the neonatal mouse liver with pseudotyped retroviral vectors.
Enzyme immunoassay of HBeAg employing beta-D-galactosidase.
Evaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems.
Gene delivery into hepatocytes with the preS/liposome/DNA system.
Genetically engineered diphtheria toxin fusion proteins carrying the hepatitis B surface antigen.
Hepatitis B virus X protein overcomes stress-induced premature senescence by repressing p16(INK4a) expression via DNA methylation.
Protein folding in the cytoplasm of Escherichia coli: requirements for the DnaK-DnaJ-GrpE and GroEL-GroES molecular chaperone machines.
Protein Kinase Activity of the Insulin Receptor Is Essential for Insulin-Regulated Gene Expression.
Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells.
Selection of recombinant vaccinia viruses (Tian Tan strain) expressing hepatitis B virus surface antigen by using beta-galactosidase as a marker.
The HBV HBX gene expressed in E. coli is recognised by sera from hepatitis patients.
The Varicella-Zoster Virus Genome.
Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes.
Use of the hemagglutinating virus of Japan (HVJ)-liposome method for analysis of infiltrating lymphocytes induced by hepatitis B virus gene expression in liver tissue.
[Construction and properties of a hybrid operon coding the HBcAG and beta-galactosidase of the hepatitis B virus in Escherichia coli]
Hepatitis C
Effect of interferon alpha and cell cycle progression on translation mediated by the hepatitis C virus 5' untranslated region: a study using a transgenic mouse model.
Noncytopathic flavivirus replicon RNA-based system for expression and delivery of heterologous genes.
The hepatitis C virus internal ribosome entry site facilitates efficient protein synthesis in blood vessel endothelium during tumour angiogenesis.
[Immune responses of a recombined live Salmonella typhimurium SL3261 expressing a multi-epitope antigen of HCV]
Hepatitis, Chronic
Detection by western blotting of an antibody to the hepatitis C virus E1 envelope protein in sera of patients with chronic liver disease.
Hepatoblastoma
Gene transfer of pigment epithelium-derived factor suppresses tumor growth and angiogenesis in a hepatoblastoma xenograft model.
Herpes Simplex
A bi-functional reporter plasmid for the simultaneous transient expression assay of two herpes simplex virus promoters.
A herpes simplex virus mutant in which glycoprotein D sequences are replaced by beta-galactosidase sequences binds to but is unable to penetrate into cells.
A herpes simplex virus-1 vector containing the rat tyrosine hydroxylase promoter directs cell type-specific expression of beta-galactosidase in cultured rat peripheral neurons.
A live non-neurovirulent herpes simplex virus vector expresses beta-galactosidase in the nervous system of the Wistar and Sprague-Dawley strain rat for a prolonged period.
Adenoviral infection of thyroid cells: a rationale for gene therapy for metastatic thyroid carcinoma.
Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma.
Adenovirus-mediated gene therapy for experimental spinal cord tumors: tumoricidal efficacy and functional outcome.
Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer.
An efficient deletion mutant packaging system for defective herpes simplex virus vectors: potential applications to human gene therapy and neuronal physiology.
Analysis of a multi-mutant herpes simplex virus type 1 for gene transfer into sympathetic preganglionic neurons and a comparison to adenovirus vectors.
Antiviral susceptibility testing with a cell line which expresses beta-galactosidase after infection with herpes simplex virus.
beta-Gal enzyme activity driven by the HSV LAT promoter does not correspond to beta-gal RNA levels in mouse trigeminal ganglia.
Beta-galactosidase as a marker in the peripheral and neural tissues of the herpes simplex virus-infected mouse.
Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter.
Confirmation of low-titer, herpes simplex virus-positive specimen results by the enzyme-linked virus-inducible system (ELVIS) using PCR and repeat testing.
Delivery of a foreign gene to sympathetic preganglionic neurons using recombinant herpes simplex virus.
Differential transfection efficiency rates of the GM-CSF gene into human renal cell carcinoma lines by lipofection.
Direct gene transfer to the liver with herpes simplex virus type 1 vectors: transient production of physiologically relevant levels of circulating factor IX.
Effect of genomic location on expression of beta-galactosidase mRNA controlled by the herpes simplex virus type 1 UL38 promoter.
Effect of immunity on gene delivery into anterior horn motor neurons by live attenuated herpes simplex virus vector.
Effect of trichostatin a and 5'-azacytidine on transgene reactivation in U937 transduced cells.
Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival.
Enhancement of neuronal protection from oxidative stress by glutamic acid decarboxylase delivery with a defective herpes simplex virus vector.
Evaluation of a genetically engineered cell line and a histochemical beta-galactosidase assay to detect herpes simplex virus in clinical specimens.
Expression of beta-galactosidase in neurons of dorsal root ganglia which are latently infected with herpes simplex virus type 1.
Expression of the calcium-binding protein, parvalbumin, in cultured cortical neurons using a HSV-1 vector system enhances NMDA neurotoxicity.
Expression of the herpes simplex virus type 1 glycoprotein C gene requires sequences in the 5' noncoding region of the gene.
Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors.
Gene therapy for mice sarcoma with oncolytic herpes simplex virus-1 lacking the apoptosis-inhibiting gene, icp34.5.
Gene therapy of chondrosarcoma using retrovirus vectors encoding the herpes simplex virus thymidine kinase gene.
Gene therapy utilizing the Cre/loxP system selectively suppresses tumor growth of disseminated carcinoembryonic antigen-producing cancer cells.
Gene transfer by viral vectors into blood vessels in a rat model of retinopathy of prematurity.
Gene transfer in bovine blastocysts using replication-defective retroviral vectors packaged with Gibbon ape leukemia virus envelopes.
Gene transfer into enteric neurons of the rat small intestine in organ culture using a replication defective recombinant herpes simplex virus type 1 (HSV1) vector, but not recombinant adenovirus vectors.
Gene transfer into sympathetic preganglionic neurons in vivo using a non-replicating thymidine kinase-deficient herpes simplex virus type 1.
Gene transfer into the mammalian inner ear using HSV-1 and vaccinia virus vectors.
Generation of recombinant herpes simplex virus type 1 to be used for automatic tract tracing.
Herpes simplex type1:lacZ recombinant viruses. II. Microtiter plate-based colorimetric assays for the discovery of new antiherpes agents and the points at which such agents disrupt the viral replication cycle.
Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency.
Immunogenicity in mice of tandem repeats of an epitope from herpes simplex gD protein when expressed by recombinant adenovirus vectors.
Immunological properties of an N-terminal fragment of herpes simplex virus type 1 glycoprotein D expressed in Escherichia coli.
Immunomodulation by topical particle-mediated administration of cytokine plasmid DNA suppresses herpetic stromal keratitis without impairment of antiviral defense.
In vivo adenovirus-mediated suicide gene therapy of orthotopic bladder cancer.
In vivo demethylation of a MoMuLV retroviral vector expressing the herpes simplex thymidine kinase suicide gene by 5' azacytidine.
In vivo gene transfer to the brain cortex using a single injection of HSV-1 vector into the medial septum.
Inactivation of the shutoff gene (UL41) of herpes simplex virus types 1 and 2.
Infection of cultured central nervous system neurons with a defective herpes simplex virus 1 vector results in stable expression of Escherichia coli beta-galactosidase.
Influence of the helper virus on expression of beta-galactosidase from a defective HSV-1 vector, pHSVlac.
Long-term expression in sensory neurons in tissue culture from herpes simplex virus type 1 (HSV-1) promoters in an HSV-1-derived vector.
Long-term gene expression in the anterior horn motor neurons after intramuscular inoculation of a live herpes simplex virus vector.
Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing.
Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. Immunosuppression with TGF-beta 1 or vIL-10.
Muscle derived cell mediated ex vivo gene transfer to the lower urinary tract: comparison of viral vectors.
Neural spread of herpes simplex virus after anterior chamber inoculation.
Neurons differentially control expression of a herpes simplex virus type 1 immediate-early promoter in transgenic mice.
Nuclear egress and envelopment of herpes simplex virus capsids analyzed with dual-color fluorescence HSV1(17+).
Preferential gene transfer to BBN-induced rat bladder tumor by simple instillation of adenoviral vector.
Purified herpes simplex thymidine kinase Retrovector particles. I. In vitro characterization, in situ transduction efficiency, and histopathological analyses of gene therapy-treated brain tumors.
Rapid and stable gene expression in hippocampal slice cultures from a defective HSV-1 vector.
Rapid production of interleukin-2-secreting tumor cells by herpes simplex virus-mediated gene transfer: implications for autologous vaccine production.
Removal of N-linked carbohydrates decreases the infectivity of herpes simplex virus type 1.
Retroviral transfer of herpes simplex virus-thymidine kinase and beta-galactosidase genes into U937 cells with bicistronic vector.
Retroviral vector-mediated gene transfer into keratocytes in vitro and in vivo.
Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells.
Solid tissues can be manipulated ex vivo and used as vehicles for gene therapy.
Studies on in vivo gene transfer in pituitary tumors using herpes-derived and adenoviral vectors.
Suppression of tumor growth and pulmonary metastasis in murine osteosarcoma using gene therapy.
Targeted killing of carcinoembryonic antigen (CEA)-producing cholangiocarcinoma cells by polyamidoamine dendrimer-mediated transfer of an Epstein-Barr virus (EBV)-based plasmid vector carrying the CEA promoter.
Targeting and gene expression in spinal cord motor neurons following intramuscular inoculation of an HSV-1 vector.
Targeting strategy for gene delivery to carcinoembryonic antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody.
Th1-associated immune responses to beta-galactosidase expressed by a replication-defective herpes simplex virus.
The gene downstream of the gC homologue in feline herpes virus type 1 is involved in the expression of virulence.
The gene encoding the late nonstructural 36K protein of vaccinia virus is essential for virus reproduction.
The use of beta-galactosidase as a marker gene to define the regulatory sequences of the herpes simplex virus type 1 glycoprotein C gene in recombinant herpesviruses.
The Varicella-Zoster Virus Genome.
Transcriptional targeting to anterior pituitary lactotrophic cells using recombinant adenovirus vectors in vitro and in vivo in normal and estrogen/sulpiride-induced hyperplastic anterior pituitaries.
Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction.
Transgenic indicator mice for studying activated retinoic acid receptors during development.
Use of recombinant vectors derived from herpes simplex virus 1 mutant tsK for short-term expression of transgenes encoding cytoplasmic and membrane anchored proteins in postmitotic polarized cortical neurons and glial cells in vitro.
[Gene therapy of a model of glioblastoma in rats using adenovirus vector encoding the HSVtk gene]
[Gene therapy of cerebral glioblastoma by adenovirus vector. Experimental model in the rat]
[Molecular biological study of the vaccinia virus genome. IV. The late nonstructural 36K protein of vaccinia virus is vitally important]
Herpes Zoster
Characterization of the acidic N-linked glycans of the zona pellucida of prepuberal pigs by a mass spectrometric approach.
Comparative assay of varicella skin test antigens by the ELISA and RPHA tests.
Disulfide formation in bovine zona pellucida glycoproteins during fertilization: evidence for the involvement of cystine cross-linkages in hardening of the zona pellucida.
Further fractionation of the glycoprotein families of porcine zona pellucida by anion-exchange HPLC and some characterization of the separated fractions.
Histology of ovaries of female rabbits immunized with deglycosylated zona pellucida macromolecules of pigs.
Identification of an N-glycosylated region of pig zona pellucida glycoprotein ZPB that is involved in sperm binding.
Involvement of N-linked carbohydrate chains of pig zona pellucida in sperm-egg binding.
Molecular cloning of bovine zona pellucida glycoproteins ZPA and ZPB and analysis for sperm-binding component of the zona.
Sleep deprivation increases the activation of nuclear factor kappa B in lateral hypothalamic cells.
Structural characterization of the Mr = 55,000 antigen (ZP3) of porcine oocyte zona pellucida. Purification and characterization of alpha- and beta-glycoproteins following digestion of lactosaminoglycan with endo-beta-galactosidase.
Variegated expression of a mouse steroid 21-hydroxylase/beta- galactosidase transgene suggests centripetal migration of adrenocortical cells.
Histoplasmosis
Molecular cloning and characterization of a recombinant Histoplasma capsulatum antigen for antibody-based diagnosis of human histoplasmosis.
HIV Infections
A computer-based, image-analysis method to quantify HIV-1 infection in a single-cycle infectious center assay.
Activity of lysosomal exoglycosidases in saliva of patients with HIV infection.
CCD camera detection of HIV infection.
HIV-1 indicator cell lines.
Soluble HIV-1 gp120 enhances HIV-1 replication in non-dividing CD4+ T cells, mediated via cell signaling and Tat cofactor overexpression.
Ultrasensitive and more specific enzyme immunoassay (immune complex transfer enzyme immunoassay) for p24 antigen of HIV-1 in serum using affinity-purified rabbit anti-p24 Fab' and monoclonal mouse anti-p24 Fab'.
Hydrothorax
Targeting the respiratory muscles of fetal sheep for prenatal gene therapy for Duchenne muscular dystrophy.
Hyperacusis
GM1 gangliosidosis type 2 in two siblings.
Hypercalcemia
Parathyroid Hormone-Related Peptide-Linked Hypercalcemia in a Melanoma Patient Treated With Ipilimumab: Hormone Source and Clinical and Metabolic Correlates.
Hyperglycemia
Acid glycohydrolase in Chinese hamster with spontaneous diabetes. I. Depressed levels of renal alpha-galactosidase and beta-galactosidase.
Interleukin-1 receptor antagonist enhances islet engraftment without impacting serum levels of nitrite or osteopontin.
Stress-induced responses of human skin fibroblasts in vitro reflect human longevity.
Hyperlipidemias
Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats.
Hyperlipoproteinemia Type II
Partial apolipoprotein E-beta-galactosidase fusion protein expressed in Escherichia coli retains binding activity to the LDL(B/E) receptor.
Hypersensitivity
A delayed-type hypersensitivity-inducing T-cell epitope of Semliki Forest virus mediates effective T-helper activity for antibody production.
An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice.
BCG-induced mucosal immune responses.
Gene gun immunization with clinically relevant allergens aggravates allergen induced pathology and is contraindicated for allergen immunotherapy.
Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine.
Oral immunization with recombinant BCG induces cellular and humoral immune responses against the foreign antigen.
Spontaneous induction of immunoregulation by an endogenous retinal antigen.
Uptake and presentation of exogenous antigen and presentation of endogenously produced antigen by skin dendritic cells represent equivalent pathways for the priming of cellular immune responses following biolistic DNA immunization.
Hypersensitivity, Delayed
Histoenzymology of the lung. II. The behaviour of lung hydrolytic enzymes during some experimental pulmonary processes.
Hypertension
Evaluation of urinary enzyme patterns in patients with kidney diseases and primary benign hypertension.
Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia.
Hyperthyroidism
Antibodies reactive with an intracellular epitope of a recombinant 64 kDa thyroid and eye muscle protein in patients with thyroid autoimmunity and ophthalmopathy.
Differential effect of hyperthyroidism on rat epididymal glycosidases.
Impact of altered thyroid hormone status on prostatic glycosidases.
Serum lysosomal acid hydrolase activities in Graves' disease.
Hypothyroidism
Hormonal control of postnatal development of ileal neuraminidase and acid beta-galactosidase.
Ichthyosis
Arylsulphatase C activity in leukocytes of patients and carriers of X-linked ichthyosis.
Idiopathic Interstitial Pneumonias
BALF N-acetylglucosaminidase and beta-galactosidase activities in idiopathic pulmonary fibrosis.
Idiopathic Pulmonary Fibrosis
BALF N-acetylglucosaminidase and beta-galactosidase activities in idiopathic pulmonary fibrosis.
Infarction, Middle Cerebral Artery
Postischemic gene transfer of soluble Flt-1 protects against brain ischemia with marked attenuation of blood-brain barrier permeability.
Infections
A comparative study of higher primate foamy viruses, including a new virus from a gorilla.
A defective HSV-1 vector expresses Escherichia coli beta-galactosidase in cultured peripheral neurons.
A gene delivery/recall system for neurons which utilizes ribonucleotide reductase-negative herpes simplex viruses.
A herpes simplex virus-1 vector containing the rat tyrosine hydroxylase promoter directs cell type-specific expression of beta-galactosidase in cultured rat peripheral neurons.
A histone deacetylase inhibitor enhances adenoviral infection of renal cancer cells.
A hybrid herpesvirus infectious vector based on Epstein-Barr virus and herpes simplex virus type 1 for gene transfer into human cells in vitro and in vivo.
A liquid, colorimetric presence-absence coliphage detection method.
A neuron-specific gene transfer by a recombinant defective Sindbis virus.
A new retroviral vector, CA1, to identify and select for cells expressing an inserted gene in vitro and in vivo.
A phi 80 function inhibitory for growth of lambdoid phage in him mutants of Escherichia coli deficient in integration host factor. II. Physiological analysis of the abortive infection.
A rapid assay to screen for drug-resistant herpes simplex virus.
A rapid method for detection of mutations in the lacI gene using PCR-single strand conformation polymorphism analysis: demonstration of its high sensitivity.
A recombinant vaccinia virus infects Xenopus melanophores.
A simple and efficient procedure for the oral inoculation of Trichoplusia ni larvae with polyhedrin-negative recombinant baculovirus.
A transgenic mouse with beta-Galactosidase as a fetal liver self-antigen for immunotherapy studies.
Abortive infection in HeLaCD4 cells by a primary HIV type 1 isolate: implications for differential host cell tropism.
Activation of a beta-galactosidase recombinant provirus: application to titration of human immunodeficiency virus (HIV) and HIV-infected cells.
Adeno-associated virus-mediated gene transfer into rat carotid arteries.
Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent.
Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent.
Adenoviral infection of thyroid cells: a rationale for gene therapy for metastatic thyroid carcinoma.
Adenoviral transduction of human 'clinical grade' immature dendritic cells enhances costimulatory molecule expression and T-cell stimulatory capacity.
Adenoviral transfection of isolated pancreatic islets: a study of programmed cell death (apoptosis) and islet function.
Adenoviral vector-mediated gene transfer and neurotransplantation: possibilities and limitations in grafting of the fetal rat suprachiasmatic nucleus.
Adenoviral-mediated p53 transgene expression sensitizes both wild-type and null p53 prostate cancer cells in vitro to radiation.
Adenovirus transduction to effect CD40 signalling improves the immune stimulatory activity of myeloma cells.
Adenovirus type 5 viral particles pseudotyped with mutagenized fiber proteins show diminished infectivity of coxsackie B-adenovirus receptor-bearing cells.
Adenovirus vectors differentially modulate proliferation of pituitary lactotrophs in primary culture in a mitogen and infection time-dependent manner.
Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus.
Adenovirus-based p53 gene therapy in ovarian cancer.
Adenovirus-mediated E2F-1 gene transfer efficiently induces apoptosis in melanoma cells.
Adenovirus-mediated E2F-1 gene transfer inhibits MDM2 expression and efficiently induces apoptosis in MDM2-overexpressing tumor cells.
Adenovirus-mediated E2F-1 gene transfer sensitizes melanoma cells to apoptosis induced by topoisomerase II inhibitors.
Adenovirus-mediated expression of interleukin-1 receptor antagonist in swine cells in vitro and in vivo.
Adenovirus-mediated gene expression in isolated rat pancreatic acini and individual pancreatic acinar cells.
Adenovirus-mediated gene transfer in the transplant setting. II. Successful expression of transferred cDNA in syngeneic liver grafts.
Adenovirus-mediated gene transfer into dissociated and explant cultures of rat hippocampal neurons.
Adenovirus-mediated gene transfer to human breast tumor cells: an approach for cancer gene therapy and bone marrow purging.
Adenovirus-mediated gene transfer to liver grafts: an improved method to maximize infectivity.
Adenovirus-mediated gene transfer using ex vivo perfusion of the heart graft.
Adenovirus-mediated in vivo gene transfer and expression in normal rat liver.
Adenovirus-mediated overexpression of human transforming growth factor-beta 1 in rat cardiac fibroblasts, myocytes and smooth muscle cells.
Adenovirus-mediated p53 gene therapy in nasopharyngeal cancer.
Adenovirus-mediated transfer of a dominant-negative H-ras suppresses neointimal formation in balloon-injured arteries in vivo.
Adenovirus-mediated transfer of a recombinant human alpha 1-antitrypsin cDNA to human endothelial cells.
Adenovirus-mediated transfer of CCAAT/enhancer-binding protein-alpha identifies a dominant antiproliferative role for this isoform in hepatocytes.
Adenovirus-mediated transfer of human lipase complementary DNA to the gallbladder.
Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments]
Age-dependent effects of repeated immunization with a first generation adenovirus vector on the immune response and transgene expression in young and old rats.
Aldolase C/zebrin II expression in the neonatal rat forebrain reveals cellular heterogeneity within the subventricular zone and early astrocyte differentiation.
An equine herpesvirus 1 mutant with a lacZ insertion between open reading frames 62 and 63 is replication competent and causes disease in the murine respiratory model.
Analysis of a multi-mutant herpes simplex virus type 1 for gene transfer into sympathetic preganglionic neurons and a comparison to adenovirus vectors.
Analysis of the Mycobacterium bovis hsp60 promoter activity in recombinant Mycobacterium avium.
Analysis of the shotgun expression library of the Mycobacterium tuberculosis genome for immunodominant polypeptides: potential use in serodiagnosis.
Antibody response to recombinant lambda gt11 fusion proteins in cytomegalovirus infection.
Antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor vaccine.
Antigens targeted to the Leishmania phagolysosome are processed for CD4+ T cell recognition.
Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus.
Antiviral susceptibility testing with a cell line which expresses beta-galactosidase after infection with herpes simplex virus.
Apoptosis Signal-Regulating Kinase 1 Mediates Cellular Senescence Induced by High Glucose in Endothelial Cells.
Appearance of protease activities coincides with p10 and polyhedrin-driven protein production in the baculovirus expression system: effects on yield.
Autocrine differentiation of PC12 cells mediated by retroviral vectors.
Bacteriophage T4-induced shut-off of host-specific translation.
bcl-2 expression in Spodoptera Frugiperda Sf-9 and Trichoplusia Ni BTI-Tn-5B1-4 insect cells: Effect on recombinant protein expression and cell viability.
Beta cyclodextrins enhance adenoviral-mediated gene delivery to the intestine.
Beta galactosidase release as an alternative to chromium release in cytotoxic T-cell assays.
Beta-adrenoceptor blockade markedly attenuates transgene expression from cytomegalovirus promoters within the cardiovascular system.
Bioreactor studies on temperature induction of the Q- mutant of bacteriophage lambda in Escherichia coli.
Bovine Herpesvirus 1 Entry by a Low-pH Endosomal Pathway.
Carcinoma induction following direct in situ transfer of v-Ha-ras into rat mammary epithelial cells using replication-defective retrovirus vectors.
Caspase activation and changes in Bcl-2 family member protein expression associated with E2F-1-mediated apoptosis in human esophageal cancer cells.
Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence.
Cell-specific induction of sensitivity to ganciclovir in medullary thyroid carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase.
Characterization of gene expression in recombinant Escherichia coli cells infected with phage lambda.
Characterization of Lactobacillus bulgaricus Bacteriophage ch2.
Characterization of the Streptococcus pneumoniae BgaC protein as a novel surface beta-galactosidase with specific hydrolysis activity for the Galbeta1-3GlcNAc moiety of oligosaccharides.
Clusters of Cl- channels in CFTR-expressing Sf9 cells switch spontaneously between slow and fast gating modes.
Colicin Ib does not cause plasmid-promoted abortive phage infection of Escherichia coli K-12.
Combined cytosine deaminase expression, 5-fluorocytosine exposure, and radiotherapy increases cytotoxicity to cholangiocarcinoma cells.
Comprehensive mapping of receptor-functioning domains in feline leukemia virus subgroup C receptor FLVCR1.
Confirmation of low-titer, herpes simplex virus-positive specimen results by the enzyme-linked virus-inducible system (ELVIS) using PCR and repeat testing.
Construction and characterization of herpes simplex virus type 1 mutants with conditional defects in immediate early gene expression.
Construction and properties of a mutant of herpes simplex virus type 1 with glycoprotein H coding sequences deleted.
Construction of a recombinant Anticarsia gemmatalis nucleopolyhedrovirus (AgMNPV-2D) harbouring the beta-galactosidase gene.
Cytotoxic effect of a replication-incompetent adenoviral vector with cytosine deaminase gene driven by L-plastin promoter in hepatocellular carcinoma cells.
Cytotoxic effects of Ad5CMV-p53 expression in two human nasopharyngeal carcinoma cell lines.
Decreased messenger RNA translation in herpesvirus-infected arterial cells: effects on cholesteryl ester hydrolase.
Defective herpes simplex virus vectors expressing the rat brain stress-inducible heat shock protein 72 protect cultured neurons from severe heat shock.
Delivery of recombinant adeno-associated virus by jet injection.
Dendritic morphology of cardiac related medullary neurons defined by circuit-specific infection by a recombinant pseudorabies virus expressing beta-galactosidase.
Development of an expression strategy using a lytic phage to trigger explosive plasmid amplification and gene expression.
Development of Engineered Bacteriophages for Escherichia coli Detection and High-Throughput Antibiotic Resistance Determination.
Development of Th1 imprints to rBCG expressing a foreign protein: implications for vaccination against HIV-1 and diverse influenza strains.
Differences in protein synthesis between wild type and intracellular growth-deficient strains of Legionella pneumophila in U937 and Acanthamoeba polyphaga.
Differential efficacy of adenoviral mediated gene transfer into cells from hematological cell lines and fresh hematological malignancies.
Disabled infectious single cycle herpes simplex virus (DISC-HSV) is a candidate vector system for gene delivery/expression of GM-CSF in human prostate cancer therapy.
E2F-1 gene therapy induces apoptosis and increases chemosensitivity in human pancreatic carcinoma cells.
Ectopic expression of Smad7 inhibits transforming growth factor-beta responses in vascular smooth muscle cells.
Effect of an adenoviral vector that expresses the canine p53 gene on cell growth of canine osteosarcoma and mammary adenocarcinoma cell lines.
Effect of infection with ribonucleic acid bacteriophage R23 on the inducible synthesis of beta-galactosidase in Escherichia coli.
Effect of mitochondrial and/or cytosolic glycerol 3-phosphate dehydrogenase overexpression on glucose-stimulated insulin secretion from MIN6 and HIT cells.
Effect of Partial Medium Replacement on Cell Growth and Protein Production for the High-Fivetrade mark insect cell line.
Effective adenovirus-mediated gene expression in adult murine skeletal muscle.
Efficacy of multiple administrations of a recombinant adenovirus expressing wild-type p53 in an immune-competent mouse tumor model.
Efficient adenovirus-mediated gene transfer into human blood monocyte-derived macrophages.
Efficient adenovirus-mediated gene transfer to gastric tissue by oral administration.
Efficient and selective adenovirus-mediated gene transfer into vascular neointima.
Efficient gene transfer and long-term expression in neurons using a recombinant adenovirus with a neuron-specific promoter.
Efficient gene transfer into cardiac myocytes using adeno-associated virus (AAV) vectors.
Efficient regulation of gene expression by adenovirus vector-mediated delivery of the CRE recombinase.
Efficient retrovirus-mediated cytokine-gene transduction of primary-cultured human glioma cells for tumor vaccination therapy.
Endogenous expression of an anti-TAR aptamer reduces HIV-1 replication.
Endothelial cells present antigens in vivo.
Engineering regulable Escherichia coli beta-galactosidases as biosensors for anti-HIV antibody detection in human sera.
Enhanced selective gene expression by adenovirus vector using Cre/loxP regulation system for human carcinoembryonic antigen-producing carcinoma.
Enhanced transgene expression in urothelial cancer gene therapy with histone deacetylase inhibitor.
Enhancement of obliterative airway disease in rat tracheal allografts infected with recombinant rat cytomegalovirus.
Enhancement of the adenoviral sensitivity of human ovarian cancer cells by transient expression of coxsackievirus and adenovirus receptor (CAR).
Enhancer stimulation unmasks latent gene transfer after adenovirus-mediated gene delivery into human vascular smooth muscle cells.
eNOS gene transfer to vascular smooth muscle cells inhibits cell proliferation via upregulation of p27 and p21 and not apoptosis.
Evaluation of a genetically engineered cell line and a histochemical beta-galactosidase assay to detect herpes simplex virus in clinical specimens.
Evaluation of monitoring approaches and effects of culture conditions on recombinant protein production in baculovirus-infected insect cells.
Ex vivo and in vivo gene transfer to the skin using replication-deficient recombinant adenovirus vectors.
Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening.
Experimental gene therapy for an in vitro model of proliferative vitreoretinopathy.
Expression analysis of the matrix GLA protein and VE-cadherin gene promoters in the outflow pathway.
Expression of an adenovirus encoded reporter gene and its reactivation following UVC and oxidative damage in cultured fish cells.
Expression of antimicrobial peptide genes after infection by parasitoid wasps in Drosophila.
Expression of the calcium-binding protein, parvalbumin, in cultured cortical neurons using a HSV-1 vector system enhances NMDA neurotoxicity.
Expression of the prodrug-activating enzyme DT-diaphorase via Ad5 delivery to human colon carcinoma cells in vitro.
Expression of transgenes in normal and neoplastic anterior pituitary cells using recombinant adenoviruses: long term expression, cell cycle dependency, and effects on hormone secretion.
Factors influencing recombinant protein yields in an insect cell-bacuiovirus expression system: Multiplicity of infection and intracellular protein degradation.
Field Evaluation of Two Colorimetric Coliphage Detection Methods.
Function of PRRSV GP5 envelope protein by using pseudotyped virus.
Functional consequences of adenovirus-mediated murine pancreatic gene transfer.
Functional role of protein kinase B/Akt in gastric acid secretion.
Galectin-2 Has Bactericidal Effects against Helicobacter pylori in a ?-galactoside-Dependent Manner.
Gene dosage as a regulatory factor for gene expression. I. In lambda plac5-infected cells.
Gene transfer in bovine blastocysts using replication-defective retroviral vectors packaged with Gibbon ape leukemia virus envelopes.
Gene transfer in dendritic cells, induced by oral DNA vaccination with Salmonella typhimurium, results in protective immunity against a murine fibrosarcoma.
Gene transfer to avian embryos with a recombinant adenovirus.
Gene transfer to human rheumatoid synovial tissue engrafted in SCID mice.
Genetic modification of the vessel wall. Comparison of surgical and catheter-based techniques for delivery of recombinant adenovirus.
Grafting genetically modified cells into the rat brain: characteristics of E. coli beta-galactosidase as a reporter gene.
Growth suppression of human ovarian cancer cell lines by the introduction of a p16 gene via a recombinant adenovirus.
Growth suppression of human ovarian cancer cells by adenovirus-mediated transfer of the PTEN gene.
HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses.
Heat-directed gene targeting of adenoviral vectors to tumor cells.
Heat-directed suicide gene therapy for breast cancer.
Herpes simplex type 1:lacZ recombinant viruses. I. Characterization and application to defining the mechanisms of action of known antiherpes agents.
Herpes simplex virus type 1 promoter activity during latency establishment, maintenance, and reactivation in primary dorsal root neurons in vitro.
High efficiency gene transfer into cultured primary rat and human hepatic stellate cells using baculovirus vectors.
Higher Throughput Quantification of Neutralizing Antibody to Herpes Simplex Viruses.
Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus.
Human bone marrow stromal cells are efficiently transduced by vesicular stomatitis virus-pseudotyped retrovectors without affecting subsequent osteoblastic differentiation.
Human cytomegalovirus infection in a retinoblastoma cell line in vitro.
Human PBMC-derived dendritic cells transduced with an adenovirus vectorinduce cytotoxic T-lymphocyte responses against a vector-encoded antigen in vitro.
Identification of Streptococcus pneumoniae genes specifically induced in mouse lung tissues.
Immunomodulation by topical particle-mediated administration of cytokine plasmid DNA suppresses herpetic stromal keratitis without impairment of antiviral defense.
In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug.
In vitro infection of megakaryocytes and their precursors by human cytomegalovirus.
IN VITRO TRANSPLANTATION OF GENETICALLY MODIFIED CELLS TO THE TENDON SURFACE.
In vivo and in vitro modulation of immune stimulatory capacity of primary dendritic cells by adenovirus-mediated gene transduction.
In vivo cytotoxicity of ovarian cancer cells through tumor-selective expression of the BAX gene.
In vivo gene transfer in mouse skeletal muscle mediated by baculovirus vectors.
In vivo marking of spontaneous or vaccine-induced fibrosarcomas in the domestic house cat, using an adenoviral vector containing a bifunctional fusion protein, GAL-TEK.
Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function.
Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: in vivo comparison of distinct GFAP-lacZ transgenes.
Inducible expression of a foreign gene inserted into the human cytomegalovirus genome.
Infection by bacterial pathogens expressing type III secretion decreases luciferase activity: ramifications for reporter gene studies.
Infection of cultured central nervous system neurons with a defective herpes simplex virus 1 vector results in stable expression of Escherichia coli beta-galactosidase.
Infection of cultured striatal neurons with a defective HSV-1 vector: implications for gene therapy.
Inflammation-Associated Senescence Promotes Helicobacter pylori-Induced Atrophic Gastritis.
Influence of expression and cis-acting sequences from avian leukosis viruses (ALVs) on stability of (ALV)-based retrovirus vectors.
Inhibition of beta-galactosidase synthesis in Escherichia coli after infection with different DNA and RNA phages.
Inhibition of HIV-1 in cell culture by oligonucleotide-loaded nanoparticles.
Inhibition of HIV-1 replication by newly developed adamantane-containing polyanionic agents.
Inhibition of melanoma growth by adenoviral-mediated HSV thymidine kinase gene transfer in vivo.
Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor.
Innate and adaptive host response during the initial phase of herpes simplex virus encephalitis in the neonatal mouse.
Insertional mutagenesis of the murine cytomegalovirus genome: one prominent alpha gene (ie2) is dispensable for growth.
Integration of active human beta-galactosidase gene (100 kb) into genome using HSV/AAV amplicon vector.
International network for comparison of HIV neutralization assays: the NeutNet report.
Intestinal infection with Nematospiroides dubius selectively increases lactase expression by mouse jejunal enterocytes.
Intratumoral vaccination of adenoviruses expressing fusion protein RM4/tumor necrosis factor (TNF)-alpha induces significant tumor regression.
Isolation of a cell line for rapid and sensitive histochemical assay for the detection of herpes simplex virus.
Isolation of lambda amp3 genomic recombinants coding for antigens of Eimeria tenella.
Leishmania major interferes with antigen presentation by infected macrophages.
Long-term expression in sensory neurons in tissue culture from herpes simplex virus type 1 (HSV-1) promoters in an HSV-1-derived vector.
Long-term expression of a foreign gene from a unique position in the latent herpes simplex virus genome.
Long-term transgene expression in mice infected with a herpes simplex virus type 1 mutant severely impaired for immediate-early gene expression.
Loss of epithelial integrity resulting from E-cadherin dysfunction predisposes airway epithelial cells to adenoviral infection.
Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.
Lysosomal enzyme in Mastomys natalensis during Dipetalonema viteae infection.
Manipulation of the cytoplasmic and transmembrane domains alters cell surface levels of the coxsackie-adenovirus receptor and changes the efficiency of adenovirus infection.
Maximization of recombinant protein yield in the insect cell/baculovirus system by one-time addition of nutrients to high-density batch cultures.
Microcarrier culture of lepidopteran cell lines: implications for growth and recombinant protein production.
Migrational analysis of the constitutively proliferating subependyma population in adult mouse forebrain.
Modification to the capsid of the adenovirus vector that enhances dendritic cell infection and transgene-specific cellular immune responses.
Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector.
Modulation of host immune responses stimulated by Salmonella vaccine carrier strains by using different promoters to drive the expression of the recombinant antigen.
Molecular characterization of a phage-inducible middle promoter and its transcriptional activator from the lactococcal bacteriophage phi31.
Molecular cloning and expression of an immunodominant 53-kDa excretory-secretory antigen from Trichinella spiralis muscle larvae.
Moloney murine leukemia virus infects cells of the developing hair follicle after neonatal subcutaneous inoculation in mice.
Murine cytomegalovirus immediate-early promoter directs astrocyte-specific expression in transgenic mice.
Mutants of bacteriophage T4 deficient in the ability to induce nuclear disruption: shutoff of host DNA and protein synthesis gene dosage experiments, identification of a restrictive host, and possible biological significance.
N-acetylcysteine augments adenovirus-mediated gene expression in human endothelial cells by enhancing transgene transcription and virus entry.
Negative complementation of recA protein by recA1 polypeptide: in vivo recombination requires a multimeric form of recA protein.
Nerve growth factor is a potent inducer of proliferation and neuronal differentiation for adult rat chromaffin cells in vitro.
Neuron-targeted gene transfer by adenovirus carrying neural-restrictive silencer element.
Neuronal expression and regulation of CGRP promoter activity following viral gene transfer into cultured trigeminal ganglia neurons.
Nitric oxide from the inducible nitric oxide synthase (iNOS) increases the expression of cytochrome P450 2E1 in iNOS-null hepatocytes in the absence of inflammatory stimuli.
Nonessential genes of phage phiYeO3-12 include genes involved in adaptation to growth on Yersinia enterocolitica serotype O:3.
Nonreplicating vaccinia vector efficiently expresses recombinant genes.
Occurrence of V-factor (NAD) independent strains of Haemophilus paragallinarum.
Optimal production of recombinant protein by the baculovirus-insect cell system in shake-flask culture with medium replacement.
Optimising fed-batch production of recombinant proteins using the baculovirus expression vector system.
Optimizing cardiovascular gene therapy: increased vascular gene transfer with modified adenoviral vectors.
Oral vaccination with modified vaccinia virus Ankara attached covalently to TMPEG-modified cationic liposomes overcomes pre-existing poxvirus immunity from recombinant vaccinia immunization.
Over-expression of hepatic neutral cytosolic cholesteryl ester hydrolase in mice increases free cholesterol and reduces expression of HMG-CoAR, CYP27, and CYP7A1.
Overexpression of IL-8 in the cornea induces ulcer formation in the SCID mouse.
Overexpression of mutated IkappaBalpha inhibits vascular smooth muscle cell proliferation and intimal hyperplasia formation.
p53 trans-dominantly suppresses tumor formation of human breast cancer cells mediated by retroviral bulk infection without marker gene selection: an expeditious in vitro protocol with implications towards gene therapy.
Parvoviruses are inefficient in inducing interferon-beta, tumor necrosis factor-alpha, or interleukin-6 in mammalian cells.
Perineurium originates from fibroblasts: demonstration in vitro with a retroviral marker.
Physiological and environmental factors affecting the growth of insect cells and infection with baculovirus.
Plant Disease and the Regulation of Enzymes Involved in Lignification: Increased Rate of De Novo Synthesis of the Three Tobacco O-Methyltransferases during the Hypersensitive Response to Infection by Tobacco Mosaic Virus.
Potential of a recombinant antigen as a prophylactic vaccine for day-old broiler chickens against Eimeria acervulina and Eimeria tenella infections.
Poxvirus as a vector to transduce human dendritic cells for immunotherapy: abortive infection but reduced APC function.
Practical aspects of the development of ex vivo and in vivo gene therapy for Parkinson's disease.
Prevention of herpes simplex virus infection and latency by prophylactic treatment with acyclovir in a weanling mouse model.
Priming of a beta-galactosidase (beta-GAL)-specific type 1 response in BALB/c mice infected with beta-GAL-transfected Leishmania major.
Production of a sialylated N-linked glycoprotein in insect cells: role of glycosidases and effect of harvest time on glycosylation.
Production of recombinant protein by baculovirus-infected insect cells in immobilized culture using porous biomass support particles.
Production of recombinant proteins by baculovirus-infected gypsy moth cells.
Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.
Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.
Protein folding studies in vivo with a bacteriophage T4 expression-packaging-processing vector that delivers encapsidated fusion proteins into bacteria.
Quantification of cell culture factors affecting recombinant protein yields in baculovirus-infected insect cells.
Quiescent viral genomes in human fibroblasts after infection with herpes simplex virus type 1 Vmw65 mutants.
Rapid and stable gene expression in hippocampal slice cultures from a defective HSV-1 vector.
Rapid detection of HSV with an enzyme-linked virus inducible system (ELVIS) employing a genetically modified cell line.
Rapid identification and quantitation of cells infected by recombinant herpesvirus (pseudorabies virus) using a fluorescence-based beta-galactosidase assay and flow cytometry.
Rapid phenotypic drug susceptibility assay for HIV-1 with a CCR5 expressing indicator cell line.
Rapid production of interleukin-2-secreting tumor cells by herpes simplex virus-mediated gene transfer: implications for autologous vaccine production.
Recombinant adeno-associated virus for the generation of autologous, gene-modified tumor vaccines: evidence for a high transduction efficiency into primary epithelial cancer cells.
Recombinant adenovirus-transduced human dendritic cells engineered to secrete interleukin-10 (IL-10) suppress Th1-type responses while selectively activating IL-10-producing CD4+ T cells.
Recombinant fusion protein and DNA vaccines against foot and mouth disease virus infection in guinea pig and swine.
Recombinant Semliki forest virus infects and kills human prostate cancer cell lines and prostatic duct epithelial cells ex vivo.
Reduced synthesis of beta-galactosidase in Escherichia coli infected with phage phi X 174.
Reduction of islet amylin expression and basal secretion by adenovirus-mediated delivery of amylin antisense cDNA.
Regulated expression of a Sindbis virus replicon by herpesvirus promoters.
Regulated expression of the feline panleukopenia virus P38 promoter on extrachromosomal FPV/EBV chimeric plasmids.
Regulation of cytomegalovirus gene expression: alpha and beta promoters are trans activated by viral functions in permissive human fibroblasts.
Replication-defective virus infection of feather buds produces a localized region of beta-galactosidase activity.
Reporter gene expression in cell culture stages and oocysts of Eimeria nieschulzi (Coccidia, Apicomplexa).
Reproduction of antiviral effect in an in vivo model of human cytomegalovirus retinal infection.
Resolution of the pathway taken by implanted Schwann cells to a spinal cord lesion by prior infection with a retrovirus encoding beta-galactosidase.
Restriction of vaccinia virus replication in CHO cells occurs at the stage of viral intermediate protein synthesis.
Resurfacing of articular cartilage explants with genetically-modified human chondrocytes in vitro.
Retrograde and anterograde labeling of cerebellar afferent projection by the injection of recombinant adenoviral vectors into the mouse cerebellar cortex.
Retroviral infection and expression of cationic amino acid transporters in rodent hepatocytes.
Retroviral mediated transfer and expression of exogenous genes in primary lymphoid cells: assaying for a viral transactivator activity in normal and malignant cells.
Role of seminal plasma in the anti-HIV-1 activity of candidate microbicides.
Role of Sphingomyelin in Alphaherpesvirus Entry.
Salmonella vaccine carrier strains: effective delivery system to trigger anti-tumor immunity by oral route.
Screening of insect cell lines for the production of recombinant proteins and infectious virus in the baculovirus expression system.
Selective neointimal gene transfer in an avian model of vascular injury.
Significant increase of adenovirus infectivity in glioma cell lines by extracellular domain of hCAR.
Silencing of retroviral vector transduced LacZ reporter gene by frameshift mutation.
Site-specific gene expression in vivo by direct gene transfer into the arterial wall.
Site-specific stable insertion into the human cytomegalovirus genome of a foreign gene under control of the SV40 promoter.
Smooth muscle alpha-actin downregulation in cultured chick aortic smooth muscle and neural crest cells is associated with altered cell shape.
Snare protein expression and adenoviral transfection of amphicrine AR42J.
Streptococcus suis Type 2 SSU0587 Protein is a Beta-Galactosidase that Contributes to Bacterial Adhesion but Not to Virulence in Mice.
Strong and regulated expression of Escherichia coli beta-galactosidase in insect cells with a baculovirus vector.
Study of the chemical nature of Frp/3 cell recognition units for hepatitis A virus.
Sub-retroviral particles as gene transfer vectors that by-pass retrovirus-receptor interaction restrictions.
Substrate limitation in the baculovirus expression vector system.
Successful retroviral mediated transduction of a reporter gene in human dendritic cells: feasibility of therapy with gene-modified antigen presenting cells.
Suicide gene expression induced in tumour cells transduced with recombinant adenoviral, retroviral and plasmid vectors containing the ERBB2 promoter.
Superinfection prevents recombination of the alphaherpesvirus bovine herpesvirus 1.
Suppression of neuronal and cardiac transient outward currents by viral gene transfer of dominant-negative Kv4.2 constructs.
T cell activation following infection of primary follicle center lymphoma B cells with adenovirus encoding CD154.
The 5' noncoding region sequence of the Choristoneura biennis entomopoxvirus spheroidin gene functions as an efficient late promoter in the mammalian vaccinia expression system.
The expression of the Escherichia coli lacZ gene in Streptomyces.
The induction and kinetics of antigen-specific CD8 T cells are defined by the stage specificity and compartmentalization of the antigen in murine toxoplasmosis.
The major tegumental antigen of Fasciola hepatica contains repeated elements.
The organotypic multicellular spheroid is a relevant three-dimensional model to study adenovirus replication and penetration in human tumors in vitro.
The overexpression of copper-zinc superoxide dismutase protects NOS III from nitric oxide-mediated inhibition.
The phage promoter responsible for the expression of the inserted beta-galactosidase gene in bacteriophage lambda plac5.
The role of serpinb9/serine protease inhibitor 6 in preventing granzyme B-dependent hepatotoxicity.
The RR1 gene of herpes simplex virus type 1 is uniquely trans activated by ICP0 during infection.
Toxicity of replication-defective adenoviral recombinants in dissociated cultures of nervous tissue.
Transactivator protein BICP0 of bovine herpesvirus 1 (BHV-1) is blocked by prostaglandin D2 (PGD2), which points to a mechanism for PGD2-mediated inhibition of BHV-1 replication.
Transcriptional targeting of herpes simplex virus for cell-specific replication.
Transduction of cultured fish cells with recombinant baculoviruses.
Transduction of the liver with activated Akt normalizes portal pressure in cirrhotic rats.
Transgenic cell lines for detection of animal viruses.
Trophic activity of Rabies G protein-pseudotyped equine infectious anemia viral vector mediated IGF-I motor neuron gene transfer in vitro.
Trypanosoma cruzi infection does not impair major histocompatibility complex class I presentation of antigen to cytotoxic T lymphocytes.
UCP2-dependent proton leak in isolated mammalian mitochondria.
Ultrarapid, highly efficient viral gene transfer to the heart.
Use of a retroviral vector with an internal opsin promoter to direct gene expression to retinal photoreceptor cells.
Use of a stationary bed reactor and serum-free medium for the production of recombinant proteins in insect cells.
Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells.
Use of recombinant herpes simplex virus type 1 vectors for gene transfer into tumour and normal anterior pituitary cells.
Use of retroviral vectors to introduce and express the beta-galactosidase marker gene in cultured chicken primordial germ cells.
Utilization of the herpes simplex virus type 1 latency-associated regulatory region to drive stable reporter gene expression in the nervous system.
Utilization of trans-activated T4 uvsY regulatory signal for a high yield of cloned gene products.
Vaccinia as a tool for functional analysis in regenerating limbs: ectopic expression of Shh.
Vaccinia virus-bacteriophage T7 expression vector for complementation analysis of late gene processes.
Vasomotor dysfunction early after exposure of normal rabbit arteries to an adenoviral vector.
Viral-mediated gene transfer to mouse primary neural progenitor cells.
Visualization of a recombinant gene protein in the baculovirus expression vector system using confocal scanning laser microscopy.
[Expression of foreign genes in adult rats' central nervous system by use of defective herpes simplex virus type 1 vectors]
[Study of lysosomal enzymes in chick embryo fibroblasts infected with microorganisms of family Halprowiaceae (Chlamydiaceae)]
[Using reporter gene to compare infection efficiency of HIV-1 pseudovirus to suspended and adherent cells].
Infertility, Male
iTRAQ-based proteomic analysis of fertile and sterile flower buds from a genetic male sterile line 'AB01' in Chinese cabbage (Brassica campestris L. ssp. pekinensis).
Influenza, Human
Chondrocyte antigen expression, immune response and susceptibility to arthritis.
Complex structure of the nuclear translocation signal of influenza virus polymerase PA subunit.
Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle.
Inhibition of mouse liver sialidase by plant flavonoids.
Myeloid dendritic cells stimulate both Th1 and Th2 immune responses depending on the nature of the antigen.
Removal of carbohydrate from influenza A virus and its hemagglutinin and the effect on biological activities.
TAP-dependent major histocompatibility complex class I presentation of soluble proteins using listeriolysin.
The role of carbohydrate in determining the immunochemical properties of the hemagglutinin of influenza A virus.
Transfectant influenza A viruses are effective recombinant immunogens in the treatment of experimental cancer.
[Role of carbohydrates in the manifestation of the hemagglutinating and neuraminidase activities of the influenza virus]
[The isolation and expression in E. coli of a recombinant plasmid containing the 3'-terminal fragment of the cDNA of the influenza A virus nucleoprotein gene]
Intellectual Disability
Acid hydrolases in serum from patients with lysosomal disorders.
Generalized gangliosidosis: acid beta-galactosidase deficiency with early onset, rapid mental deterioration and minimal bone dysplasia.
Juvenile neurogenic muscle atrophy with lysosomal enzyme deficiencies: new disease or variant of mucopolysaccharidosis?
Intervertebral Disc Degeneration
Senescence in human intervertebral discs.
Intervertebral Disc Displacement
Senescence in human intervertebral discs.
Irritable Bowel Syndrome
Lactase and placebo in the management of the irritable bowel syndrome: a double-blind, cross-over study.
Keloid
Gene transfer into human keloid tissue with adeno-associated virus vector.
Keratoconjunctivitis
[The discovery and study on invasive strain of Escherichia coli O121]
Kidney Diseases
Urinary acidic glycohydrolases as an index of kidney damage in juvenile diabetes mellitus.
Kwashiorkor
Lysosomal enzymuria in protein energy malnutrition.
lactase deficiency
An acidophilic beta-galactosidase from Bispora sp. MEY-1 with high lactose hydrolytic activity under simulated gastric conditions.
Enzyme replacement therapy for primary adult lactase deficiency. Effective reduction of lactose malabsorption and milk intolerance by direct addition of beta-galactosidase to milk at mealtime.
Separation and characterization of four enzyme forms of beta-galactosidase from Saccharomyces lactis.
Lactose Intolerance
A novel acid-stable, acid-active beta-galactosidase potentially suited to the alleviation of lactose intolerance.
Application relevant studies of fungal beta-galactosidases with potential application in the alleviation of lactose intolerance.
Beneficial effects of oral tilactase on patients with hypolactasia.
beta-Galactosidase from Aspergillus niger in adult lactose malabsorption: a double-blind crossover study.
Beta-galactosidase tablets in the treatment of lactose intolerance in pediatrics.
Effect of exogenous beta-galactosidase in patients with lactose malabsorption and intolerance: a crossover double-blind placebo-controlled study.
Effects of exogenous lactase administration on hydrogen breath excretion and intestinal symptoms in patients presenting lactose malabsorption and intolerance.
Efficacy testing of beta-galactosidase with H2 breath test in patients with carbohydrate malabsorption.
Engineering of a fungal beta-galactosidase to remove product inhibition by galactose.
Enzyme replacement for lactose malabsorption using a beta-D-galactosidase.
Enzyme replacement therapy for primary adult lactase deficiency. Effective reduction of lactose malabsorption and milk intolerance by direct addition of beta-galactosidase to milk at mealtime.
Frequency of lactose malabsorption among healthy southern and northern Indian populations by genetic analysis and lactose hydrogen breath and tolerance tests.
Genotyping of the lactase-phlorizin hydrolase -13910 polymorphism by LightCycler PCR and implications for the diagnosis of lactose intolerance.
Identification of bacteria with beta-galactosidase activity in faeces from lactase non-persistent subjects.
Improvement of lactose digestion in humans by ingestion of unfermented milk containing Bifidobacterium longum.
Milk intolerance and microbe-containing dairy foods.
One step partial purification of beta-D-galactosidase from Kluyveromyces marxianus CDB 002 using STREAMLINE-DEAE.
Peroral gene therapy of lactose intolerance using an adeno-associated virus vector.
Production of yoghurt with mild taste by a Lactobacillus delbrueckii subsp. bulgaricus mutant with altered proteolytic properties.
Targeted PLGA-microparticles as a novel concept for treatment of lactose intolerance.
The effect of oral supplementation with Lactobacillus reuteri or tilactase in lactose intolerant patients: randomized trial.
The T-13910C polymorphism in the lactase phlorizin hydrolase gene is associated with differences in serum calcium levels and calcium intake.
Treatment of lactose intolerance with exogenous beta-D-galactosidase in pellet form.
Use of chemical mutagenesis for the isolation of food grade beta-galactosidase overproducing mutants of bifidobacteria, lactobacilli and Streptococcus thermophilus.
Latent Infection
A latent, nonpathogenic HSV-1-derived vector stably expresses beta-galactosidase in mouse neurons.
beta-Gal enzyme activity driven by the HSV LAT promoter does not correspond to beta-gal RNA levels in mouse trigeminal ganglia.
Decreased reporter gene expression during latent infection with HSV LAT promoter constructs.
Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency.
Long-term expression of a reporter gene from latent herpes simplex virus in the rat hippocampus.
Prevention of herpes simplex virus infection and latency by prophylactic treatment with acyclovir in a weanling mouse model.
Reactivation of latent cytomegalovirus infection in mouse brain cells detected after transfer to brain slice cultures.
Leiomyoma
Nonviral vector-mediated thymidine kinase gene transfer and ganciclovir treatment in leiomyoma cells.
Lentivirus Infections
[Kcnq1ot1 promotes osteogenic differentiation and suppresses osteoclast differentiation].
Leukemia
A latent, nonpathogenic HSV-1-derived vector stably expresses beta-galactosidase in mouse neurons.
A new system for stringent, high-titer vesicular stomatitis virus G protein-pseudotyped retrovirus vector induction by introduction of Cre recombinase into stable prepackaging cell lines.
A retroviral vector containing a muscle-specific enhancer drives gene expression only in differentiated muscle fibers.
Accelerated cellular senescence in myelodysplastic syndrome.
Assembly of gag-beta-galactosidase proteins into retrovirus particles.
Chemical modification of an ecotropic murine leukemia virus results in redirection of its target cell specificity.
Detection of in vivo differentiation of murine WEHI-3B D+ leukemia cells transfected with the lac-Z marker gene using two-color flow cytometry.
Development of a lacZ marked WEHI-3B D+ murine leukemic cell line as an in-vivo model of acute non-lymphocytic leukemia.
Development of a safe and rapid neutralization assay using murine leukemia virus pseudotyped with HIV type 1 envelope glycoprotein lacking the cytoplasmic domain.
Does pH 6 beta-galactosidase activity indicate cell senescence?
Does thalidomide affect IL-2 response and production?
Expression of human factor IX in mice after injection of genetically modified myoblasts.
Expression of Pax-3- and neuroectoderm-inducing activities during differentiation of P19 embryonal carcinoma cells.
Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability.
Factors affecting long-term stability of Moloney murine leukemia virus-based vectors.
Function of PRRSV GP5 envelope protein by using pseudotyped virus.
Human parainfluenza virus type 3: analysis of the cytoplasmic tail and transmembrane anchor of the hemagglutinin-neuraminidase protein in promoting cell fusion.
In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug.
Inactivation of the Moloney murine leukemia virus long terminal repeat in murine fibroblast cell lines is associated with methylation and dependent on its chromosomal position.
Integration of embryonic stem cells in metanephric kidney organ culture.
Long-term expression of a reporter gene from latent herpes simplex virus in the rat hippocampus.
Optimization of human erythropoietin secretion from MLV-infected human primary fibroblasts used for encapsulated cell therapy.
Retroviral vector-mediated gene transfer into human primary myogenic cells leads to expression in muscle fibers in vivo.
Retrovirus-mediated gene transfer in lungs of living fetal sheep.
Retrovirus-mediated transfer and expression of marker genes in the BN rat acute myelocytic leukemia model for the study of minimal residual disease (MRD).
Serum and host liver activities of glycosidases and sialyltransferases in animals bearing transplantable tumors.
Silencing of retroviral vector transduced LacZ reporter gene by frameshift mutation.
Solid tissues can be manipulated ex vivo and used as vehicles for gene therapy.
Sperm endogenous reverse transcriptase as mediator of new genetic information.
Stable incorporation of a bacterial gene into adult rat skeletal muscle in vivo.
Successful transfection of biotinylated beta-galactosidase gene conjugated with transferrin into leukemia cells and interleukin-2-stimulated lymphocytes via transferrin receptor.
Targeted retroviral gene transfer into the rat biliary tract.
Targeting and gene expression in spinal cord motor neurons following intramuscular inoculation of an HSV-1 vector.
Targeting strategy for gene delivery to carcinoembryonic antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody.
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins.
Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991.
Transient detection of beta-galactosidase activity in hematopoietic cells, following reinjection of retrovirally marked autologous blood progenitors in patients with breast or ovarian cancer receiving high-dose chemotherapy.
Trophoblast type-specific expression of senescence markers in the human placenta.
Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos.
Variable transduction efficiency of murine leukemia retroviral vector on mammalian cells: role of cellular glycosylation.
Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine-thymine tracts.
Leukemia, Erythroblastic, Acute
Differential large-scale chromatin compaction and intranuclear positioning of transcribed versus non-transcribed transgene arrays containing beta-globin regulatory sequences.
Eosinophils inhibit retroviral transduction of human target cells by a ribonuclease-dependent mechanism.
Protein glycans alteration and a different distribution of some enzymatic activities involved in the glycan processing are found in AZT-treated K562 cells.
Recombinant adeno-associated virus-mediated gene transfer into hematopoietic progenitor cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Gangliosides of human chronic lymphocytic leukemia and hairy cells.
Leukemia, Myeloid
1H NMR studies of a biosynthetic lacto-ganglio hybrid glycosphingolipid: confirmation of structure, interpretation of "anomalous" chemical shifts, and evidence for interresidue amide-amide hydrogen bonding.
Enzyme release assay of human NK cell activity using beta-galactosidase-expressing K562 target cell line.
Leukemia, Myeloid, Acute
Retrovirus-mediated transfer and expression of marker genes in the BN rat acute myelocytic leukemia model for the study of minimal residual disease (MRD).
Leukemia, T-Cell
Biochemical activities of lysosomal acid hydrolases in leukemic cells.
Envelope proteins of human T-cell leukemia virus: expression in Escherichia coli and its application to studies of env gene functions.
Heterologous protein expression affects the death kinetics of baculovirus-infected insect cell cultures: a quantitative study by use of n-target theory.
Leukemia-Lymphoma, Adult T-Cell
Expression of the x-lor gene of human T-cell leukemia virus I in Escherichia coli.
Leukodystrophy, Globoid Cell
A protein activator of galactosylceramide beta-galactosidase.
Chemical pathology of krabbe's disease. IV. Studies of galactosylceramide and lactosylceramide BETA-galactosidases in brain, white blood cells and aminotic fluid cells.
Effect of bile salts on lactosylceramide beta-galactosidase activities in human brain, liver and cultured skin fibroblasts.
Enzyme replacement with liposomes containing beta-galactosidase from Charonia lumpas in murine globoid cell leukodystrophy (twitcher).
Galactosylceramide- and lactosylceramide-loading studies in cultured fibroblasts from normal individuals and patients with globoid cell leukodystrophy (Krabbe's disease) and GM1-gangliosidosis.
Globoid cell leukodystrophy: deficiency of lactosyl ceramide beta-galactosidase.
Hydrolysis of galactosylsphingosine and lactosylsphingosine by beta-galactosidases in human brain and cultured fibroblasts.
Lactosylceramide beta-galactosidase in human sphingolipidoses. Evidence for two genetically distinct enzymes.
Molecular beacon genotyping for globoid cell leukodystrophy from hair roots in the twitcher mouse and rhesus macaque.
Prenatal enzymatic diagnosis and exclusion of Krabbe's disease (globoid-cell leukodystrophy) using chorionic villi in five risk pregnancies.
Prenatal enzymatic diagnosis of Krabbe disease (globoid-cell leukodystrophy) using chorionic villi. Pitfalls in the use of uncultured villi.
Prenatal enzymic diagnosis in 24 pregnancies with risk of Krabbe disease .
Psychosine is as potent an inducer of cell death as C6-ceramide in cultured fibroblasts and in MOCH-1 cells.
Residual galactosylsphingosine (psychosine) beta-galactosidase activities and associated GALC mutations in late and very late onset Krabbe disease.
Specificity of galactosylceramidase activation by phosphatidylserine.
[Krabbe disease (globoid cell leukodystrophy): a case report]
Leukodystrophy, Metachromatic
Juvenile-onset metachromatic leukodystrophy: biochemical and electrophysiologic studies.
Lipidoses
A new form of ovine GM1-gangliosidosis.
Liver Cirrhosis
Increased serum alpha-L-fucosidase and beta-N-acetylglucosaminidase activities in diabetic, cirrhotic and gastric cancer patients.
Liver Cirrhosis, Biliary
Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss.
Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence.
Liver Diseases
Detection by western blotting of an antibody to the hepatitis C virus E1 envelope protein in sera of patients with chronic liver disease.
Optimisation of an enzymatic method for beta-galactosidase.
Liver Failure, Acute
Cellular senescence in livers from children with end stage liver disease.
Liver Neoplasms
Development of pyrrolo[2,1-c][1,4]benzodiazepine beta-galactoside prodrugs for selective therapy of cancer by ADEPT and PMT.
Lumpy Skin Disease
Importance of thymidine kinase activity for normal growth of lumpy skin disease virus (SA-Neethling).
Lung Injury
Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury.
Lung Neoplasms
Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells.
Cell death induced by down-regulation of heat shock protein 70 in lung cancer cell lines is p53-independent and does not require DNA cleavage.
High levels of gene transduction in human lung tumors following intralesional injection of recombinant adenovirus.
IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death.
Induction of premature senescence in human lung cancer by fungal immunomodulatory protein from Ganoderma tsugae.
Longitudinal follow-up of cellular and humoral immunity induced by recombinant adenovirus-mediated gene therapy in cancer patients.
Phase I trial of recombinant adenovirus gene transfer in lung cancer. Longitudinal study of the immune responses to transgene and viral products.
Radiation-mediated up-regulation of gene expression from replication-defective adenoviral vectors: implications for sodium iodide symporter gene therapy.
Recombinant adenovirus shedding after intratumoral gene transfer in lung cancer patients.
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.
Tumor-specific gene delivery mediated by a novel peptide-polyethylenimine-DNA polyplex targeting aminopeptidase N/CD13.
Lyme Disease
Activity of lysosomal exoglycosidases in the serum of patients with chronic Lyme arthritis.
Alpha fucosidase and beta galactosidase in serum of a Lyme disease patients as a possible marker of accelerated senescence - a preliminary study.
Lymphadenopathy
Suppression of autoimmune disease and of massive lymphadenopathy in MRL/Mp-lpr/lpr mice lacking tyrosine kinase Fyn (p59fyn).
Lymphocytic Choriomeningitis
The lymphocytic choriomeningitis virus envelope glycoprotein targets lentiviral gene transfer vector to neural progenitors in the murine brain.
Lymphoma
Efficient gene transfer into lymphoma cells using adenoviral vectors combined with lipofection.
Efficient transduction of murine B lymphocytes and B lymphoma lines by modified adenoviral vectors: enhancement via targeting to FcR and heparan-containing proteins.
Identification of the glucose transporter in mammalian cell membranes with a 125I-forskolin photoaffinity label.
In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug.
Live attenuated measles virus induces regression of human lymphoma xenografts in immunodeficient mice.
p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis.
Suitability of Epstein-Barr virus-based episomal vectors for expression of cytokine genes in human lymphoma cells.
T cell activation following infection of primary follicle center lymphoma B cells with adenovirus encoding CD154.
Lymphoma, B-Cell
Suitability of Epstein-Barr virus-based episomal vectors for expression of cytokine genes in human lymphoma cells.
Lysosomal Storage Diseases
A case of galactosialidosis with a homozygous Q49R point mutation.
A case of galactosialidosis.
A duplication in the canine beta-galactosidase gene GLB1 causes exon skipping and GM1-gangliosidosis in Alaskan huskies.
A Single Injection of an Optimized Adeno-Associated Viral Vector into Cerebrospinal Fluid Corrects Neurological Disease in a Murine Model of GM1 Gangliosidosis.
Active-site motifs of lysosomal acid hydrolases: invariant features of clan GH-A glycosyl hydrolases deduced from hydrophobic cluster analysis.
Beta-galactosidase activity in fibroblasts and tissues from sheep with a lysosomal storage disease.
Cathepsin A deficiency in galactosialidosis: studies of patients and carriers in 16 families.
Cerebrospinal fluid biomarkers showing neurodegeneration in dogs with GM1 gangliosidosis: possible use for assessment of a therapeutic regimen.
Complete Correction of Enzymatic Deficiency and Neurochemistry in the GM1-gangliosidosis Mouse Brain by Neonatal Adeno-associated Virus-mediated Gene Delivery.
Diagnosis of unsuspected fetal metabolic storage disease by routine placental examination.
Elimination of abnormal sialylglycoproteins in fibroblasts with sialidosis and galactosialidosis by normal gene transfer and enzyme replacement.
Enhanced proteolytic degradation of normal beta-galactosidase in the lysosomal storage disease with combined beta-galactosidase and neuraminidase deficiency.
GM1 gangliosidosis and Morquio B disease: an update on genetic alterations and clinical findings.
Impact of beta-galactosidase mutations on the expression of the canine lysosomal multienzyme complex.
Inheritance of an ovine lysosomal storage disease associated with deficiencies of beta-galactosidase and alpha-neuraminidase.
Inherited lysosomal storage disease associated with deficiencies of beta-galactosidase and alpha-neuraminidase in sheep.
Interspecific genetic complementation analysis of human and sheep fibroblasts with beta-galactosidase deficiency.
Lectin histochemistry of an ovine lysosomal storage disease with deficiencies of beta-galactosidase and alpha-neuraminidase.
Mechanisms of distribution of mouse beta-galactosidase in the adult GM1-gangliosidosis brain.
Molecular mechanism of lysosomal sialidase deficiency in galactosialidosis involves its rapid degradation.
Molecular pathology of galactosialidosis in a patient affected with two new frameshift mutations in the cathepsin A/protective protein gene.
N-butyldeoxygalactonojirimycin reduces neonatal brain ganglioside content in a mouse model of GM1 gangliosidosis.
New mutations in two Dutch patients with early infantile galactosialidosis.
Rapid and accurate G M1-gangliosidosis diagnosis using a parentage testing microsatellite.
Six novel beta-galactosidase gene mutations in Brazilian patients with GM1-gangliosidosis.
Substrate reduction reduces gangliosides in postnatal cerebrum-brainstem and cerebellum in GM1 gangliosidosis mice.
The structures of six urinary oligosaccharides that are characteristic for a patient with Morquio syndrome type B.
Three novel beta-galactosidase gene mutations in Han Chinese patients with GM1 gangliosidosis are correlated with disease severity.
Ultrastructural lesions of ovine GM1 gangliosidosis.
[The role of ophthalmological examination in the diagnosis of gangliosidosis GM1].
Malabsorption Syndromes
Intestinal beta-galactosidase activities in malabsorption syndromes.
Malaria
Conditional expression in the malaria mosquito Anopheles stephensi with Tet-On and Tet-Off systems.
In Vitro Activities of MMV Malaria Box Compounds against the Apicomplexan Parasite Neospora caninum, the Causative Agent of Neosporosis in Animals.
In vitro screening of the open source Pathogen Box identifies novel compounds with profound activities against Neospora caninum.
OmpA fusion proteins for presentation of foreign antigens on the bacterial outer membrane.
Recombinant Plasmodium falciparum glutamate rich protein; purification and use in enzyme-linked immunosorbent assay.
Requirements for screening recombinant DNA libraries for T cell epitope expression.
Malnutrition
Effect of prenatal exposure to ethanol on intestinal development of rat fetuses.
Lactase phlorizin hydrolase synthesis is decreased in protein-malnourished pigs.
Lactase synthesis is pretranslationally regulated in protein-deficient pigs fed a protein-sufficient diet.
Neonatal undernutrition and short term administration of hydrocortisone and thyroxine: effects on rat brain hydrolases.
Massive Hepatic Necrosis
Cellular senescence in livers from children with end stage liver disease.
Measles
Construction of fowlpox virus vectors with intergenic insertions: expression of the beta-galactosidase gene and the measles virus fusion gene.
Synthesis of the membrane fusion and hemagglutinin proteins of measles virus, using a novel baculovirus vector containing the beta-galactosidase gene.
Melanoma
A melanoma cell line sensitive to expression of a fusion protein binding the retinoblastoma protein family pocket domain.
Adenoviral-mediated herpes simplex virus-thymidine kinase gene transfer in vivo for treatment of experimental human melanoma.
Adenovirus-mediated E2F-1 gene transfer efficiently induces apoptosis in melanoma cells.
Adenovirus-mediated E2F-1 gene transfer sensitizes melanoma cells to apoptosis induced by topoisomerase II inhibitors.
Distinct roles of adenovirus vector-transduced dendritic cells, myoblasts, and endothelial cells in mediating an immune response against a transgene product.
Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes.
Elastin-derived peptides upregulate matrix metalloproteinase-2-mediated melanoma cell invasion through elastin-binding protein.
Evaluation of a nude mouse tumor model using beta-galactosidase-expressing melanoma cells.
Ex vivo and in vivo adenovirus-mediated gene therapy strategies induce a systemic anti-tumor immune defence in the B16 melanoma model.
Generation of an intensely potent anthracycline by a monoclonal antibody-beta-galactosidase conjugate.
In vitro and in vivo targeting of gene expression to melanoma cells.
In vitro and in vivo transfection of plasmid DNA in the Dunning prostate tumor R3327-AT1 is enhanced by focused ultrasound.
Induction of protective anti-tumor immunity by gene-modified dendritic cells.
Inhibition of c-Myc oncoprotein limits the growth of human melanoma cells by inducing cellular crisis.
Intensely cytotoxic anthracycline prodrugs: galactosides.
Melanoma-specific cytotoxicity induced by a tyrosinase promoter-enhancer/herpes simplex virus thymidine kinase adenovirus.
Nucleofection is a highly effective gene transfer technique for human melanoma cell lines.
Parathyroid Hormone-Related Peptide-Linked Hypercalcemia in a Melanoma Patient Treated With Ipilimumab: Hormone Source and Clinical and Metabolic Correlates.
Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma.
Repeated cationic multilamellar liposome-mediated gene transfer enhanced transduction efficiency against murine melanoma cell lines.
Simultaneous radiolabel, genetic tagging and proliferation assays to study the organ distribution and fate of metastatic cells.
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma.
Spleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest.
Therapeutic immune response induced by electrofusion of dendritic and tumor cells.
Transcriptional targeting of recombinant adenoviruses to human and murine melanoma cells.
Tumor suppression without differentiation or apoptosis by antisense cyclin D1 gene transfer in K1735 melanoma involves induction of p53, p21WAF1 and superoxide dismutases.
[Establishment of mouse melanoma model expressing beta-galactosidase and its application in the research of DNA vaccines against tumor]
Melanoma, Amelanotic
The phototumorigenic fluoroquinolone, lomefloxacin, photosensitises p53 accumulation and transcriptional activity in human skin cells.
Melanoma, Experimental
A flow cytometric method for the rapid detection of beta-galactosidase transfected cells: an in vitro and in vivo study.
Comparative analysis of antigen loading strategies of dendritic cells for tumor immunotherapy.
Ex vivo and in vivo adenovirus-mediated gene therapy strategies induce a systemic anti-tumor immune defence in the B16 melanoma model.
In vitro and in vivo targeting of gene expression to melanoma cells.
Meningioma
Gene dosage effect in cells with monosomy of chromosome 22 derived from human meningiomas.
Selective intraarterial gene delivery into a canine meningioma.
Mesenteric Lymphadenitis
Increased activity of lysosomal enzymes in the peritoneal fluid of bacterial peritonitis.
Mesothelioma
Immuno-gene therapy with interferon-beta before surgical debulking delays recurrence and improves survival in a murine model of malignant mesothelioma.
Transfer into a mesothelioma cell line of tumor suppressor gene p16 by cholesterol-based cationic lipids.
Mesothelioma, Malignant
Direct in vivo gene transfer and expression in malignant cells using adenovirus vectors.
In vivo transfer of bacterial marker genes results in differing levels of gene expression and tumor progression in immunocompetent and immunodeficient mice.
Metabolism, Inborn Errors
Immunostaining of human amniotic epithelial cells: possible use as a transgene carrier in gene therapy for inborn errors of metabolism.
[Recent advances in inborn errors of metabolism]
Mouth Neoplasms
Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells.
Mucolipidoses
A comparative study of sialyloligosaccharides isolated from sialidosis and galactosialidosis urine.
A new type of mucolipidosis with beta-galactosidase dificiency and glycopeptiduria.
Adult mucolipidosis with beta-galactosidase and neuraminidase deficiencies.
Adult type mucolipidosis with beta-galactosidase and sialidase deficiency. Histological and biochemical studies.
Application of epithelial cells in culture to the biochemical studies of lysosomal hydrolase deficiencies.
beta-Galactosidase deficient-type mucolipidosis: a complementation study of neuraminidase in somatic cell hybrids.
beta-Galactosidase in mucopolysaccharidoses and mucolipidoses. Deficiency of GM1 beta-galactosidase in liver and leukocytes.
Carrier detection of sialidosis with partial beta-galactosidase deficiency by the assay of lysosomal sialidase in lymphocytes.
Characterization of beta-D-galactosidase isolated from I-cell disease liver.
Characterization of human lysosomal neuraminidase defines the molecular basis of the metabolic storage disorder sialidosis.
Cloning of the cDNA and gene encoding mouse lysosomal sialidase and correction of sialidase deficiency in human sialidosis and mouse SM/J fibroblasts.
Early proteolytic cleavage with loss of a C-terminal fragment underlies altered processing of the beta-galactosidase precursor in galactosialidosis.
Electron microscopic examination of skin and conjunctival biopsy specimens in neuronal storage diseases.
Electrophoretic analysis of glycoprotein enzymes in the sialidoses and mucolipidoses.
Elimination of abnormal sialylglycoproteins in fibroblasts with sialidosis and galactosialidosis by normal gene transfer and enzyme replacement.
Exclusion of NEU1 and PPGB from candidate genes for a lysosomal storage disease in Japanese Black cattle.
Four positional isomers of sialyloligosaccharides isolated from the urine of a patient with sialidosis.
Genetic heterogeneity in human neuraminidase deficiency.
Human beta-galactosidase and alpha-neuraminidase deficient mucolipidosis: genetic complementation analysis of the neuraminidase deficiency.
Hypersialyloligosacchariduria in mucolipidoses: a method for diagnosis.
I-Cell disease: isoelectric focusing, concanavalin A-Sepharose 4B binding and kinetic properties of human liver acid beta-D-galactosidases.
Km defect in neuraminidase of dysmorphic type sialidosis with and without beta-galactosidase deficiency.
Lymphoblastoid cell lines, transformed by Epstein-Barr virus, in the enzymatic study of hereditary lysosomal storage diseases.
Lysosomal hydrolases in blood-derived macrophages of patients with I-cell disease.
Lysosomal sialidase deficiency in sialidosis with partial beta-galactosidase deficiency.
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs.
Metabolic disorders characterized by angiokeratomas and neurologic dysfunction.
Mucolipidosis I: studies of sialidase activity and a prenatal diagnosis.
Mucolipidosis II and III: different residual activity of beta-galactosidase in cultured fibroblasts.
Mucolipidosis III: two patients displaying genetic pleiotropism.
Neuraminidase activities in sialidosis and mucolipidosis.
Neuraminidase deficiency and accumulation of sialic acid in lymphocytes in adult type sialidosis with partial beta-galactosidase deficiency.
Neuraminidase in mucolipidoses: normal activity in frozen autopsy tissues from three patients with I-cell disease and adult beta-galactosidase deficiency.
Neurochemical abnormality in I-cell disease: chemical analysis and a possible importance of beta-galactosidase deficiency.
Partial characterization and studies of fibroblast and leucocyte neuraminidase activities towards sialyloligosaccharides in adult sialidosis and mucolipidosis II and III.
Prenatal diagnosis of sialidosis with combined neuraminidase and beta-galactosidase deficiency.
Properties of acid beta-D-galactosidase isolated from I-cell disease brain and spleen.
Radioassay method of neuraminidase towards N-acetylneuraminosyl hexasaccharides.
Signaling pathways transduced through the elastin receptor facilitate proliferation of arterial smooth muscle cells.
Structure of a novel sialooligosaccharide from the urine of a patient with mucolipidosis.
The complementation of beta-galactosidase in fused cells of mucolipidosis II with another variants of beta-galactosidase deficiency using new single cell enzyme assay.
The effect of (+) --cyanidanol on lysosomal enzymes of I-cell fibroblasts.
Transport of human lysosomal neuraminidase to mature lysosomes requires protective protein/cathepsin A.
Two positional isomers of sialylheptasaccharides isolated from the urine of a patient with sialidosis.
Ultrastructural and immunocytochemical study of skin fibroblasts from normal and sialidosis patients.
Urinary lysosomal hydrolases in mucolipidosis II and mucolipidosis III.
Urinary sialyloligosaccharides in adult type sialidosis: occurrence of two positional isomers.
[A case of adult type sialidosis with partial beta-galactosidase deficiency without myoclonus]
[Adult mucolipidosis with beta-galactosidase deficiency: a clinical report, with studies of urinary sialic acid-rich substances (author's transl)]
[Sialidosis and galactosialidosis as the cause of non-immunologic hydrops fetalis]
Mucopolysaccharidoses
Acid hydrolases in serum from patients with lysosomal disorders.
An improved method for the detection of beta-galactosidase activity, and its application to G MI-gangliosidosis and mucopolysaccharidosis.
beta-Galactosidase in mucopolysaccharidoses and mucolipidoses. Deficiency of GM1 beta-galactosidase in liver and leukocytes.
GM1 gangliosidosis type 2 in two siblings.
Interspecific genetic complementation analysis of human and sheep fibroblasts with beta-galactosidase deficiency.
Morquio B patient/caregiver survey: First insight into the natural course of a rare GLB1 related condition.
Mutation analyses in 17 patients with deficiency in acid beta-galactosidase: three novel point mutations and high correlation of mutation W273L with Morquio disease type B.
Novel beta-galactosidase gene mutation p.W273R in a woman with mucopolysaccharidosis type IVB (Morquio B) and lack of response to in vitro chaperone treatment of her skin fibroblasts.
Recent advances in Dyggve-Melchior-Clausen syndrome.
Variable clinical presentation in lysosomal storage disorders.
[Morquio syndrome moderated by beta galactosidase deficiency. Mucopolysaccharidosis (type IV B) or oligosaccharidosis]
[Mucopolysaccharidosis type IV (Morquio syndrome, beta-galactosidase deficiency)]
[Ophthalmologic and roentgenologic findings in a rare case of mucopolysaccharidosis 4 B]
Mucopolysaccharidosis I
Acid hydrolases in skin and plasma in gargoylism. Deficiency of beta-galactosidase in skin.
Beta-galactosidase deficiency in the hurler syndrome.
Deficiency of beta-galactosidase and alpha-mannosidase--primary enzyme defects in gargoylism and a new generalized disease?
Electron microscopic examination of skin and conjunctival biopsy specimens in neuronal storage diseases.
Hurler syndrome: alpha-L-iduronidase activity in leukocytes as a method for heterozygote detection.
Hurler's syndrome: deficiency of a specific beta galactosidase isoenzyme.
Lymphoblastoid cell lines, transformed by Epstein-Barr virus, in the enzymatic study of hereditary lysosomal storage diseases.
Variable clinical presentation in lysosomal storage disorders.
Mucopolysaccharidosis II
Glycosidases in skin and plasma in Hunter's syndrome. Abnormality of a beta-galactosidase in skin.
Hunter's syndrome: beta-galactosidase deficiency in skin.
Mucopolysaccharidosis IV
A beta-galactosidase gene mutation identified in both Morquio B disease and infantile GM1 gangliosidosis.
Alternative splicing of beta-galactosidase mRNA generates the classic lysosomal enzyme and a beta-galactosidase-related protein.
An autophagic vacuolar myopathy-like disorder presenting as nonimmune hydrops in a female fetus.
Atypical adult GM1 gangliosidosis: biochemical comparison with other forms of primary beta-galactosidase deficiency.
Beta galactosidase and the Morquio syndrome.
Beta-galactosidase deficiencies and novel GLB1 mutations in three Chinese patients with Morquio B disease or GM1 gangliosidosis.
Correction of acid beta-galactosidase deficiency in GM1 gangliosidosis human fibroblasts by retrovirus vector-mediated gene transfer: higher efficiency of release and cross-correction by the murine enzyme.
Electron microscopic examination of skin and conjunctival biopsy specimens in neuronal storage diseases.
Expression and characterization of 14 GLB1 mutant alleles found in GM1-gangliosidosis and Morquio B patients.
Fetal presentation of Morquio disease type A.
Generalized gangliosidosis: acid beta-galactosidase deficiency with early onset, rapid mental deterioration and minimal bone dysplasia.
GM1 gangliosidosis and Morquio B disease: an update on genetic alterations and clinical findings.
GM1 gangliosidosis and Morquio B disease: expression analysis of missense mutations affecting the catalytic site of acid beta-galactosidase.
Heterogeneity of Morquio disease.
Human beta-galactosidase gene mutations in morquio B disease.
Imbalanced substrate specificity of mutant beta-galactosidase in patients with Morquio B disease.
Impaired elastic-fiber assembly by fibroblasts from patients with either Morquio B disease or infantile GM1-gangliosidosis is linked to deficiency in the 67-kD spliced variant of beta-galactosidase.
Incorporation and degradation of GM1 ganglioside and asialoGM1 ganglioside in cultured fibroblasts from normal individuals and patients with beta-galactosidase deficiency.
Insertion of a T next to the donor splice site of intron 1 causes aberrantly spliced mRNA in a case of infantile GM1-gangliosidosis.
Interspecific genetic complementation analysis of human and sheep fibroblasts with beta-galactosidase deficiency.
Intracellular processing and maturation of mutant gene products in hereditary beta-galactosidase deficiency (beta-galactosidosis).
Kinetic properties of beta-galactosidase in Morquio B disease.
Late diagnosis of mucopolysaccharidosis type IVB and successful aortic valve replacement in a 60-year-old female patient.
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs.
Molecular basis of GM1 gangliosidosis and Morquio disease, type B. Structure-function studies of lysosomal beta-galactosidase and the non-lysosomal beta-galactosidase-like protein.
Molecular form and subcellular distribution of acid beta-galactosidase in fibroblasts from patients with GM1 gangliosidosis, Morquio B disease and galactosialidosis.
Morquio B disease: From pathophysiology towards diagnosis.
Morquio B patient/caregiver survey: First insight into the natural course of a rare GLB1 related condition.
Morquio B syndrome: a primary defect in beta-galactosidase.
Morquio syndrome (mucopolysaccharidosis IV B) associated with beta-galactosidase deficiency. Report of two cases.
Morquio's disease type B (beta-galactosidase deficiency) in three siblings.
Morquio-B disease, spondyloepiphyseal dysplasia associated with acid beta-galactosidase deficiency. Report of three cases in one family.
Morquio-like syndrome with beta galactosidase deficiency and normal hexosamine sulfatase activity: mucopolysacchariodosis IVB.
Mutation analyses in 17 patients with deficiency in acid beta-galactosidase: three novel point mutations and high correlation of mutation W273L with Morquio disease type B.
Novel beta-galactosidase gene mutation p.W273R in a woman with mucopolysaccharidosis type IVB (Morquio B) and lack of response to in vitro chaperone treatment of her skin fibroblasts.
Novel mutations (Asn 484 Lys, Thr 500 Ala, Gly 438 Glu) in Morquio B disease.
Organization of the gene encoding human lysosomal beta-galactosidase.
Processing of human beta-galactosidase in GM1-gangliosidosis and Morquio B syndrome.
Progressive mental regression in siblings with Morquio disease type B (mucopolysaccharidosis IV B).
Structural bases of GM1 gangliosidosis and Morquio B disease.
The effects of acid glycosaminoglycans on neonatal calvarian cultures--a role of keratan sulfate in Morquio syndrome?
The structures of six urinary oligosaccharides that are characteristic for a patient with Morquio syndrome type B.
Twenty-one novel mutations in the GLB1 gene identified in a large group of GM1-gangliosidosis and Morquio B patients: possible common origin for the prevalent p.R59H mutation among gypsies.
Variable clinical presentation in lysosomal storage disorders.
[beta-galactosidosis--GM1 gangliosidosis and Morquio B disease]
[Late diagnosis of Morquio syndrome. Clinical histopathological findings in a rare mucopolysaccharidosis]
[Molecular genetics of beta-galactosidase deficiency (GM1-gangliosidosis and Morquio syndrome type B)]
[Molecular pathology of neurogenetic diseases]
[Morquio syndrome moderated by beta galactosidase deficiency. Mucopolysaccharidosis (type IV B) or oligosaccharidosis]
[Morquio syndrome, beta-galactosidase deficiency]
[Mucopolysaccharidosis type IV (Morquio syndrome, beta-galactosidase deficiency)]
[Ophthalmologic and roentgenologic findings in a rare case of mucopolysaccharidosis 4 B]
Multiple Sclerosis
Diagnostic value of determinations of lysosomal hydrolases in CSF of patients with neurological diseases.
Mumps
The Varicella-Zoster Virus Genome.
Muscular Atrophy
Adult type GMl-gangliosidosis: a complementation study on somatic cell hybrids.
Juvenile neurogenic muscle atrophy with lysosomal enzyme deficiencies: new disease or variant of mucopolysaccharidosis?
Muscular Diseases
Dysferlin expression after normal myoblast transplantation in SCID and in SJL mice.
Muscular Dystrophies
Dysferlin expression after normal myoblast transplantation in SCID and in SJL mice.
Limitations of nls beta-galactosidase as a marker for studying myogenic lineage or the efficacy of myoblast transfer.
Restricted expression of cardiac myosin light chain 2A gene in muscular dystrophic condition.
Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.
Muscular Dystrophies, Limb-Girdle
Dysferlin expression after normal myoblast transplantation in SCID and in SJL mice.
Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.
Myeloproliferative Disorders
Gene dosage effect for beta-glucuronidase (GUSB) in monosomy 7 cells of patients with myeloproliferative disorders.
Platelet lysosomal enzymes are normal in myeloproliferative disorders.
Myocardial Infarction
Adenovirus-mediated gene transfer into infarcted myocardium: feasibility, timing, and location of expression.
Adenovirus-mediated overexpression of inhibitor kappa B-alpha attenuates postinfarct remodeling in the rat heart.
Can cold or heat shock improve skeletal myoblast engraftment in infarcted myocardium?
Influence of isoproterenol-induced myocardial infarction on certain glycohydrolases and cathepsins in rats.
Interventional magnetic resonance imaging for guiding gene and cell transfer in the heart.
Ischemic/reperfused myocardium can express recombinant protein following direct DNA or retroviral injection.
Serum and urinary beta-galactosidase and beta-glucuronidase activity in patients with acute myocardial infarction.
Serum beta-N-acetylglucosaminidase, beta-D-glucosidase, alpha-D-glucosidase, beta-D-fucosidase, alpha-L-fucosidase and beta-D-galactosidase levels in acute viral hepatitis, pancreatitis, myocardial infarction and breast cancer.
Synergistic effect of nicorandil and amlodipine on lysosomal hydrolases during experimental myocardial infarction in rats.
Use of recombinant adeno-associated viral vectors as a tool for labeling bone marrow cells.
Myocardial Ischemia
Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction.
[Endothelial cell senescence in human atherosclerosis: role of telomeres in endothelial dysfunction]
[Therapeutic angiogenesis with the use of vascular endothelial growth factor 165 gene in the myocardium of miniature swine]
Myocarditis
Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model.
Myoclonus
Adult GM1 gangliosidosis: clinical and biochemical studies on two patients and comparison to other patients called variant or adult GM1 gangliosidosis.
Adult type GMl-gangliosidosis: a complementation study on somatic cell hybrids.
Electrophysiological studies of myoclonus in sialidosis type 2.
Localized beta-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry-red spot--a new variant of GM1-gangliosidosis?
Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver.
Macular cherry-red spots and myoclonus with dementia: coexistent neuraminidase and beta-galactosidase deficiencies.
Neuraminidase in mucolipidoses: normal activity in frozen autopsy tissues from three patients with I-cell disease and adult beta-galactosidase deficiency.
[A case of adult type sialidosis with partial beta-galactosidase deficiency without myoclonus]
Myotonic Dystrophy
Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy.
Nasopharyngeal Carcinoma
Evidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cells.
Neoplasm Metastasis
Chemoembolisation of rat colorectal liver metastases with drug eluting beads loaded with irinotecan or doxorubicin.
Combination treatment of CC531-lac-Z rat liver metastases by chemoembolization with pemetrexed disodium and gemcitabine.
Comparative studies between nude and scid mice on the growth and metastatic behavior of xenografted human tumors.
Costimulation enhances the active immunotherapy effect of recombinant anticancer vaccines.
Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene.
Dendritic cells retrovirally transduced with a model antigen gene are therapeutically effective against established pulmonary metastases.
Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model.
Dissemination in athymic nude mice of lacZ transfected small cell lung cancer cells identified by X-gal staining.
Early characterization of a novel metastatic disease model of murine neuroblastoma.
Gene transfer of the vascular endothelial growth factor receptor flt-1 suppresses pulmonary metastasis associated with lung growth.
In vivo gene transfer of pigment epithelium-derived factor inhibits tumor growth in syngeneic murine models of thoracic malignancies.
Interleukin-10 enhances the therapeutic effectiveness of a recombinant poxvirus-based vaccine in an experimental murine tumor model.
Invasion-inhibiting factor 2-albumin conjugate inhibits invasion and spontaneous metastasis of MKL-4 human breast cancer cells transplanted into female nude mice.
Quantitative detection of lac-Z-transfected CC531 colon carcinoma cells in an orthotopic rat liver metastasis model.
Recombinant E1-deleted adenovirus-mediated gene therapy for cancer: efficacy studies with p53 tumor suppressor gene and liver histology in tumor xenograft models.
Simultaneous radiolabel, genetic tagging and proliferation assays to study the organ distribution and fate of metastatic cells.
Systemic treatment with a recombinant erbB-2 receptor-specific tumor toxin efficiently reduces pulmonary metastases in mice injected with genetically modified carcinoma cells.
The activity of serum beta-galactosidase in colon cancer patients with a history of alcohol and nicotine dependence: preliminary data.
[The relationship between hydrolases and invasion of gastric carcinoma]
Neoplasm Micrometastasis
Development of micrometastases: earliest events detected with bacterial lacZ gene-tagged tumor cells.
Gene therapy of metastatic cancer by in vivo retroviral gene targeting.
Growth characteristics in the initial stage of micrometastasis formation by bacterial LacZ gene-tagged rat prostatic adenocarcinoma cells.
Plasma Escherichia coli beta-galactosidase as a marker of tumor burden and response to experimental anti-neoplastic therapy in nude mice xenografted with lacZ transduced human tumor cells.
Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ.
Neoplasm, Residual
Antitumor effect and cellular immunity activation by murine interferon-beta gene transfer against intracerebral glioma in mouse.
Retrovirus-mediated transfer and expression of marker genes in the BN rat acute myelocytic leukemia model for the study of minimal residual disease (MRD).
Neoplasms
A 19F-NMR approach using reporter molecule pairs to assess beta-galactosidase in human xenograft tumors in vivo.
A beta-galactosidase hybrid protein targeted to nuclei as a marker for developmental studies.
A model system for testing gene vectors using murine tumor cells on the chorioallantoic membrane of the chick embryo.
A mouse embryonic stem cell line showing pluripotency of differentiation in early embryos and ubiquitous beta-galactosidase expression.
A multifunctional PEI-based cationic polyplex for enhanced systemic p53-mediated gene therapy.
A new immunocapture assay for Escherichia coli beta-galactosidase for in vivo studies of lacZ-transduced tumor cells.
A novel nonviral cytoplasmic gene expression system and its implications in cancer gene therapy.
A novel receptor-targeted gene delivery system for cancer gene therapy.
A Transgenic Mouse for Imaging Caspase-Dependent Apoptosis within the Skin.
Ablation of tumor cells in vivo by direct injection of HSV-thymidine kinase retroviral vector and ganciclovir therapy.
Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor-associated antigen.
Activity assays of nine heterogeneous promoters in neural and other cultured cells.
Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription.
Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages.
ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells.
Adeno-associated viral vector gene transfer into leptomeningeal xenografts.
Adenoviral delivery of B7-1 (CD80) increases the immunogenicity of human ovarian and cervical carcinoma cells.
Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma.
Adenoviral-mediated expression of a kinase-dead mutant of Akt induces apoptosis selectively in tumor cells and suppresses tumor growth in mice.
Adenoviral-mediated gene therapy of human bladder cancer with antisense interleukin-8.
Adenoviral-mediated p53 tumor suppressor gene therapy of human ovarian carcinoma.
Adenovirus 5 E1a-mediated gene therapy for human ovarian cancer cells in vitro and in vivo.
Adenovirus encoding soluble tumor necrosis factor alpha receptor immunoglobulin prolongs gene expression of a cotransfected reporter gene in rat lung.
Adenovirus gene transfer vectors inhibit growth of lymphatic tumor metastases independent of a therapeutic transgene.
Adenovirus vector-mediated gene transfer using degradable starch microspheres for hepatocellular carcinoma in rats.
Adenovirus-directed expression of Q227L-G alpha(s) inhibits growth of established tumors of later-stage human breast cancer cells in athymic mice.
Adenovirus-mediated combined P16 gene and GM-CSF gene therapy for the treatment of established tumor and induction of antitumor immunity.
Adenovirus-mediated E2F-1 gene transfer inhibits MDM2 expression and efficiently induces apoptosis in MDM2-overexpressing tumor cells.
Adenovirus-mediated gene therapy for experimental spinal cord tumors: tumoricidal efficacy and functional outcome.
Adenovirus-mediated gene therapy in an experimental model of breast cancer metastatic to the brain.
Adenovirus-mediated gene therapy of experimental gliomas.
Adenovirus-mediated gene transfer to orthotopic hepatocellular carcinomas in athymic nude mice.
Adenovirus-mediated interferon-beta gene therapy suppresses growth and metastasis of human prostate cancer in nude mice.
Adenovirus-mediated p53 gene delivery inhibits 9L glioma growth in rats.
Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments]
Adrenocortical-specific transgene expression directed by steroid hydroxylase gene promoters.
Alterations of glycosidases in benign, premalignant and malignant human lesions.
Altered epigenetic patterning leading to replicative senescence and reduced longevity. A role of a novel SNF2 factor, PASG.
An in vitro immuno-enzymatic assay of tumor antigens in the mouse with beta-galactosidase.
An intracellular anti-erbB-2 single-chain antibody is specifically cytotoxic to human breast carcinoma cells overexpressing erbB-2.
Anti-tumor activity of cytotoxic T lymphocytes elicited with recombinant and synthetic forms of a model tumor-associated antigen.
Anti-tumor immunity against CT26 colon tumor in mice immunized with plasmid DNA encoding beta-galactosidase fused to an envelope protein of endogenous retrovirus.
Antigen-specific tumor vaccine efficacy in vivo against prostate cancer with low class I MHC requires competent class II MHC.
Antitumor effect of in vivo somatostatin receptor subtype 2 gene transfer in primary and metastatic pancreatic cancer models.
Antitumoral efficacy of DNA nanoparticles in murine models of lung cancer and pulmonary metastasis.
B cell tumor vaccine enhanced by covalent attachment of immunoglobulin to surface proteins on dendritic cells.
Bacterial delivery of a novel cytolysin to hypoxic areas of solid tumors.
Beta galactosidase mediated bio-enzymatically synthesized nano-gold with aggrandized cytotoxic potential against pathogenic bacteria and cancer cells.
Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses.
Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection.
Beta-N-acetylglucosaminidase, beta-galactosidase, and alpha-mannosidase activities in human female genital cancer.
BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion.
Biological roles of the non-integrin elastin/laminin receptor.
Brain tumor therapy by combined vaccination and antisense oligonucleotide delivery with nanoparticles.
Cancer gene therapy using tumor cells infected with recombinant vaccinia virus expressing GM-CSF.
Cancer-inducible transgene expression by the Grp94 promoter: spontaneous activation in tumors of various origins and cancer-associated macrophages.
Cell-specific, multidrug delivery system using streptavidin-protein A fusion protein.
Characteristics of a potent tumor vaccine-induced secondary anti-tumor T cell response.
Characterization of Senescence of Human Adipose-Derived Stem Cells After Long-Term Expansion.
Characterization of spontaneous metastasis in an aggressive breast carcinoma model using flow cytometry.
Chemopreventive agents induce a senescence-like phenotype in rat mammary tumours.
Chronic in vitro exposure to 3'-azido-2', 3'-dideoxythymidine induces senescence and apoptosis and reduces tumorigenicity of metastatic mouse mammary tumor cells.
Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor.
Cigarette smoke induces senescence in alveolar epithelial cells.
Clonal dominance detected in metastases but not primary tumors of retrovirally marked human breast carcinoma injected into nude mice.
Co-delivery of T helper 1-biasing cytokine genes enhances the efficacy of gene gun immunization of mice: studies with the model tumor antigen beta-galactosidase and the BALB/c Meth A p53 tumor-specific antigen.
Co-expression of granulocyte-macrophage colony-stimulating factor with antigen enhances humoral and tumor immunity after DNA vaccination.
Combined intratumoral injection of bone marrow-derived dendritic cells and systemic chemotherapy to treat pre-existing murine tumors.
Comparative analyses of transgene delivery and expression in tumors inoculated with a replication-conditional or -defective viral vector.
Comparative analysis of antigen loading strategies of dendritic cells for tumor immunotherapy.
Comparative studies between nude and scid mice on the growth and metastatic behavior of xenografted human tumors.
Comparison of promoter strengths on gene delivery into mammalian brain cells using AAV vectors.
Composition of PLGA and PEI/DNA nanoparticles improves ultrasound-mediated gene delivery in solid tumors in vivo.
Conditional gene expression in human intracranial xenograft tumors.
Conjugates of COL-1 monoclonal antibody and beta-D-galactosidase can specifically kill tumor cells by generation of 5-fluorouridine from the prodrug beta-D-galactosyl-5-fluorouridine.
Construction of an EGF receptor-mediated histone H1(0)-based gene delivery system.
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence.
Correlative fine specificity of several Thomsen-Friedenreich disaccharide-binding proteins with an effect on tumor cell proliferation.
Costimulation enhances the active immunotherapy effect of recombinant anticancer vaccines.
Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases.
Cytologic detection of cervical and endometrial carcinoma with other genital tract involvement.
Cytological and biochemical methods for the characterization of in vitro cultured cells.
Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene.
Delivery of recombinant adeno-associated virus by jet injection.
Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity.
Dendritic cells retrovirally transduced with a model antigen gene are therapeutically effective against established pulmonary metastases.
Detection of Oncogene-Induced Senescence In Vivo.
Development of pyrrolo[2,1-c][1,4]benzodiazepine beta-galactoside prodrugs for selective therapy of cancer by ADEPT and PMT.
DGCR8 is essential for tumor progression following PTEN loss in the prostate.
Diagnostic value of determinations of lysosomal hydrolases in CSF of patients with neurological diseases.
Direct and indirect T cell priming by dendritic cell vaccines.
Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model.
Direct in vivo gene transfer and expression in malignant cells using adenovirus vectors.
Disabled infectious single cycle herpes simplex virus (DISC-HSV) is a candidate vector system for gene delivery/expression of GM-CSF in human prostate cancer therapy.
Discovery of new beta-D-galactosidase inhibitors via pharmacophore modeling and QSAR analysis followed by in silico screening.
Dissection of tumour and host cells from target organs of metastasis for testing gene expression directly ex vivo.
Distinct roles of adenovirus vector-transduced dendritic cells, myoblasts, and endothelial cells in mediating an immune response against a transgene product.
DNA loop sequence as the determinant for chiral supramolecular compound G-quadruplex selectivity.
Does pH 6 beta-galactosidase activity indicate cell senescence?
Dose-dependent transduction of vesicular stomatitis virus G protein-pseudotyped retrovirus vector into human solid tumor cell lines and murine fibroblasts.
E1A gene therapy inhibits angiogenesis in a Ewing's sarcoma animal model.
E2F-1 is a critical modulator of cellular senescence in human cancer.
Early characterization of a novel metastatic disease model of murine neuroblastoma.
Effect of differences in cancer cells and tumor growth sites on recruiting bone marrow-derived endothelial cells and myofibroblasts in cancer-induced stroma.
Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cells.
Efficacy of multiple administrations of a recombinant adenovirus expressing wild-type p53 in an immune-competent mouse tumor model.
Efficacy of p53 adenovirus-mediated gene therapy against human breast cancer xenografts.
Efficient adenovirus-mediated gene transfer into human blood monocyte-derived macrophages.
Efficient and cancer-selective gene transfer to hepatocellular carcinoma in a rat using adenovirus vector with iodized oil esters.
Efficient DNA electrotransfer into tumors.
Elevation of acid glycosidase activities in thyroid and gastric tumors.
Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis.
Endothelial cell implantation and survival within experimental gliomas.
Enhanced efficiency and specificity of ovarian cancer gene therapy in rats with a novel nonviral gene delivery system (GE7) via intraovarian artery perfusion approach.
Enhanced thermal stability of lysosomal beta-D-galactosidase in parenchymal cells of tumour bearing mice.
Enhancement of gene delivery to cancer cells by a retargeted adenovirus.
Enhancing efficacy of recombinant anticancer vaccines with prime/boost regimens that use two different vectors.
Enzyme activity profiles in mouse teratocarcinomas. A quantitative ultramicroscale analysis.
Enzyme-linked immunosorbent assay for the quantification of actinomycin D using beta-D-galactosidase as a label.
Ephemerally expressed wild-type and mutant steroid hormone receptors are equally able to influence expression of transient or resident templates.
Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization.
Eradication of pre-established lymphoma using herpes simplex virus amplicon vectors.
Evaluation and optimization of different cationic liposome formulations for in vivo gene transfer.
Evaluation of a nude mouse tumor model using beta-galactosidase-expressing melanoma cells.
Evaluation of gas-filled microparticles and sonoporation as gene delivery system: feasibility study in rodent tumor models.
Exploiting the lacZ reporter gene for quantitative analysis of disseminated tumor growth within the brain: use of the lacZ gene product as a tumor antigen, for evaluation of antigenic modulation, and to facilitate image analysis of tumor growth in situ.
Expression and regulation of Escherichia coli lacZ gene fusions in mammalian cells.
Expression of transgenes in normal and neoplastic anterior pituitary cells using recombinant adenoviruses: long term expression, cell cycle dependency, and effects on hormone secretion.
Fibroblast growth factor 2 restrains Ras-driven proliferation of malignant cells by triggering RhoA-mediated senescence.
Fibroblast growth factor 4 transfection of MCF-7 cells produces cell lines that are tumorigenic and metastatic in ovariectomized or tamoxifen-treated athymic nude mice.
Fidelity of a human cell DNA replication complex.
Folate receptor mediated DNA delivery into tumor cells: potosomal disruption results in enhanced gene expression.
Foreign antigenic peptides delivered to the tumor as targets of cytotoxic T cells.
Fractional laser exposure induces neutrophil infiltration (N1 phenotype) into the tumor and stimulates systemic anti-tumor immune response.
Functional analysis of the steroid hormone control region of mouse mammary tumor virus.
G-quadruplex stabilizer 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide induces accelerated senescence and inhibits tumorigenic properties in cancer cells.
Galactosyltransferase activity in metastasizing and nonmetastasizing rat mammary carcinomas and its possible relationship with tumor cell surface antigen shedding.
Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells.
Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line.
Gene delivery using a receptor-mediated gene transfer system targeted to hepatocellular carcinoma cells.
Gene expression in intrahepatic tumors through DNA recombination by a replication-activated adenovirus vector.
Gene therapy against an experimental glioma using adeno-associated virus vectors.
Gene therapy of human bladder cancer with adenovirus-mediated antisense basic fibroblast growth factor.
Gene therapy of rat medullary thyroid cancer by naked nitric oxide synthase II DNA injection.
Gene therapy utilizing the Cre/loxP system selectively suppresses tumor growth of disseminated carcinoembryonic antigen-producing cancer cells.
Gene transfer of pigment epithelium-derived factor suppresses tumor growth and angiogenesis in a hepatoblastoma xenograft model.
Gene transfer of the vascular endothelial growth factor receptor flt-1 suppresses pulmonary metastasis associated with lung growth.
Gene transfer to human rheumatoid synovial tissue engrafted in SCID mice.
Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination.
Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas.
Glycosidases of Ehrlich ascites tumor cells and ascitic fluid--purification and substrate specificity of alpha-N-acetylgalactosaminidase and alpha-galactosidase: comparison with coffee bean alpha-galactosidase.
Growth factor-mediated interaction between tumor cells and stromal fibroblasts in an experimental model of human small-cell lung cancer.
Heat-shock enhanced reactivation of a UV-damaged reporter gene in human cells involves the transcription coupled DNA repair pathway.
High levels of gene transduction in human lung tumors following intralesional injection of recombinant adenovirus.
Highly attenuated modified vaccinia virus Ankara (MVA) as an effective recombinant vector: a murine tumor model.
Histochemical demonstration of different types of poly-N-acetyllactosamine structures in human thyroid neoplasms using lectins and endo-beta-galactosidase digestion.
HoxD10 gene delivery using adenovirus/adeno-associate hybrid virus inhibits the proliferation and tumorigenicity of GH4 pituitary lactotrope tumor cells.
Hydrolytic enzyme activities of the nervous system.
Hydrolytic enzymes in meningiomal subtypes.
Identification of a Kb-restricted CTL epitope of beta-galactosidase: potential use in development of immunization protocols for "self" antigens.
IFI16 inhibits tumorigenicity and cell proliferation of bone and cartilage tumor cells.
IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death.
IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines: enhancement by simultaneous B7-1 expression.
IL-2 enhances the function of recombinant poxvirus-based vaccines in the treatment of established pulmonary metastases.
Imaging beta-galactosidase activity in human tumor xenografts and transgenic mice using a chemiluminescent substrate.
Immuno-gene therapy with interferon-beta before surgical debulking delays recurrence and improves survival in a murine model of malignant mesothelioma.
Immunopharmacological and antitumor effects of second-generation immunomodulatory oligonucleotides containing synthetic CpR motifs.
In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.
In vitro and in vivo herpetic vector-mediated gene transfer in the pituitary gland: impact on hormone secretion.
In vitro and in vivo targeting of gene expression to melanoma cells.
In vitro and in vivo transfection of plasmid DNA in the Dunning prostate tumor R3327-AT1 is enhanced by focused ultrasound.
In vivo adenovirus-mediated suicide gene therapy of orthotopic bladder cancer.
In vivo antitumor activity of Sindbis viral vectors.
In vivo cytokine gene therapy of human tumor xenografts in SCID mice by liposome-mediated DNA delivery.
In vivo cytotoxicity of ovarian cancer cells through tumor-selective expression of the BAX gene.
In vivo gene transfer of pigment epithelium-derived factor inhibits tumor growth in syngeneic murine models of thoracic malignancies.
In vivo glioma model enabling regulated gene expression.
In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors.
In vivo marking of spontaneous or vaccine-induced fibrosarcomas in the domestic house cat, using an adenoviral vector containing a bifunctional fusion protein, GAL-TEK.
In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma.
In vivo studies of adenovirus-mediated p53 gene therapy for cis-platinum-resistant human ovarian tumor xenografts.
In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy.
In vivo transfer of bacterial marker genes results in differing levels of gene expression and tumor progression in immunocompetent and immunodeficient mice.
In vivo-targeted gene delivery using antibody-based nonviral vector.
Increased activity of lysosomal enzymes in the peritoneal fluid of patients with gynecologic cancers and pelvic inflammatory disease.
Increased activity of lysosomal glycohydrolases in glioma tissue and surrounding areas from human brain.
Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1.
Increased tumor localization and reduced immune response to adenoviral vector formulated with the liposome DDAB/DOPE.
Increased type IV collagenase in lgl-induced invasive tumors of Drosophila.
Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres.
Induction of orthotopic rat adrenomedullary neoplasia by intraadrenal pheochromocytoma cell transplantation.
Induction of protective anti-tumor immunity by gene-modified dendritic cells.
Induction of senescent-like growth arrest as a new target in anticancer treatment.
Influence of gene-modified (IL-7, IL-4, and B7) tumor cell vaccines on tumor antigen presentation.
Inhibition of human P-glycoprotein transport and substrate binding using a galantamine dimer.
Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor.
Inhibition of oncogenic K-ras signaling by aerosolized gene delivery in a mouse model of human lung cancer.
Intensity of the vaccine-elicited immune response determines tumor clearance.
Interferon regulatory factor 3 activates p53-dependent cell growth inhibition.
Interleukin-7/B7.1-encoding adenoviruses induce rejection of transplanted but not nontransplanted tumors.
Intra-pinna anti-tumor vaccination with self-replicating infectious RNA or with DNA encoding a model tumor antigen and a cytokine.
Intraarterial delivery of adenovirus vectors and liposome-DNA complexes to experimental brain neoplasms.
Intracerebral adenovirus-mediated p53 tumor suppressor gene therapy for experimental human glioma.
Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation.
Intravesical liposome-mediated interleukin-2 gene therapy in orthotopic murine bladder cancer model.
Invasiveness by lacZ transfected non-small-cell lung cancer cells into human bronchial tissues in vitro.
Ionizing radiation increases adenovirus uptake and improves transgene expression in intrahepatic colon cancer xenografts.
Isolated limb perfusion in the sarcoma-bearing rat: a novel preclinical gene delivery system.
Lac/Tet dual-inducible system functions in mammalian cell lines.
Lithotripter shock waves with cavitation nucleation agents produce tumor growth reduction and gene transfer in vivo.
Live attenuated measles virus induces regression of human lymphoma xenografts in immunodeficient mice.
LNCaP prostate cancer cells are insensitive to zinc-induced senescence.
Localization of iodine-125-mIP-Des-Met14-bombesin (7-13)NH2 in ovarian carcinoma induced to express the gastrin releasing peptide receptor by adenoviral vector-mediated gene transfer.
Long-term humoral and cellular immunity induced by a single immunization with replication-defective adenovirus recombinant vector.
Low-volume jet injection for efficient nonviral in vivo gene transfer.
Lymphatic endothelial tumors induced by intraperitoneal injection of incomplete Freund's adjuvant.
Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells.
Lysosomes: a possible target for psoralen photodamage.
Macrophage activation by trehalose dimycolate requirement for an expression signal in vitro for antitumoral activity; biochemical markers distinguishing primed and fully activated macrophages.
MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors.
Measurement of beta-galactosidase tissue levels in a tumor cell xenograft model.
Measurement of tumor load and distribution in a model of cancer-induced osteolysis: a necessary precaution when testing novel anti-resorptive therapies.
MicroRNA changes in human arterial endothelial cells with senescence: relation to apoptosis, eNOS and inflammation.
Migratory patterns of lac-z transfected human glioma cells in the rat brain.
Modification to the capsid of the adenovirus vector that enhances dendritic cell infection and transgene-specific cellular immune responses.
Modulation of beta-galactosidase activity in peritoneal macrophages from C57B1 mice after exposure to Proprionibacterium acnes.
Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector.
Modulation of osteoclast function by adenovirus vector-induced epidermal growth factor receptor.
Modulation of the DNA-damage response to HZE particles by shielding.
Molecular characterization of the virulence gene virG of pTiKU 12.
Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo.
Nature and the multiple functions of the 67-kD elastin-/laminin binding protein.
Non-invasive in vivo optical imaging of the lacZ and luc gene expression in mice.
Noninvasive method of immortalized neural stem-like cell transplantation in an experimental model of Huntington's disease.
Nonviral in vivo gene delivery into tumors using a novel low volume jet-injection technology.
Notch-induced mammary tumorigenesis does not involve the lobule-limited epithelial progenitor.
Nuclear localization signals also mediate the outward movement of proteins from the nucleus.
Overexpression of the p21 sdi1 gene induces senescence-like state in human cancer cells: implication for senescence-directed molecular therapy for cancer.
Overexpression of tissue inhibitor of metalloproteinases-2 retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion.
Oxygen sensitivity of reporter genes: implications for preclinical imaging of tumor hypoxia.
p53 alone or in combination with antisense cyclin D1 induces apoptosis and reduces tumor size in human melanoma.
p53 dependent cell-cycle arrest triggered by chemotherapy in xenografted breast tumors.
p53 gene therapy in a rat model of hepatocellular carcinoma: intra-arterial delivery of a recombinant adenovirus.
Pan-Cancer Analyses Reveal Prognostic Value of Osteomimicry Across 20 Solid Cancer Types.
Persistent, antigen-specific, therapeutic antitumor immunity by dendritic cells genetically modified with an adenoviral vector to express a model tumor antigen.
Phase I study of a recombinant adenovirus-mediated gene transfer in lung cancer patients.
Phase I trial of recombinant adenovirus gene transfer in lung cancer. Longitudinal study of the immune responses to transgene and viral products.
Photoacoustic imaging of lacZ gene expression in vivo.
Plasma Escherichia coli beta-galactosidase as a marker of tumor burden and response to experimental anti-neoplastic therapy in nude mice xenografted with lacZ transduced human tumor cells.
Polycations and cationic lipids enhance adenovirus transduction and transgene expression in tumor cells.
Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application.
Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo.
Preclinical evaluation of "whole" cell vaccines for prophylaxis and therapy using a disabled infectious single cycle-herpes simplex virus vector to transduce cytokine genes.
Preferential gene transfer to BBN-induced rat bladder tumor by simple instillation of adenoviral vector.
Pretreatment with protease is a useful experimental strategy for enhancing adenovirus-mediated cancer gene therapy.
Primary graft nonfunction and Kupffer cell activation after liver transplantation from non-heart-beating donors in pigs.
Priming for T-cell-mediated rejection of established tumors by cutaneous DNA immunization.
Principal component analysis of quantitative trait loci for immune response to adenovirus in mice.
Promoter function of different lengths of the murine luteinizing hormone receptor gene 5'-flanking region in transfected gonadal cells and in transgenic mice.
Proteasome inhibitors reduce luciferase and beta-galactosidase activity in tissue culture cells.
Protein-specific cytotoxic T lymphocytes. Recognition of transfectants expressing intracellular, membrane-associated or secreted forms of beta-galactosidase.
Purified herpes simplex thymidine kinase Retrovector particles. I. In vitro characterization, in situ transduction efficiency, and histopathological analyses of gene therapy-treated brain tumors.
Quantitative and qualitative characterization of human cancer-associated serum glycoprotein antigens expressing fucosyl or sialyl-fucosyl type 2 chain polylactosamine.
Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ.
Quantitative Identification of Senescent Cells in Cancer.
Radiation-induced senescence-like terminal growth arrest in thyroid cells.
Radiation-mediated up-regulation of gene expression from replication-defective adenoviral vectors: implications for sodium iodide symporter gene therapy.
Rapid production of interleukin-2-secreting tumor cells by herpes simplex virus-mediated gene transfer: implications for autologous vaccine production.
Recombinant adeno-associated virus for the generation of autologous, gene-modified tumor vaccines: evidence for a high transduction efficiency into primary epithelial cancer cells.
Recombinant adenovirus shedding after intratumoral gene transfer in lung cancer patients.
Regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer model.
Relation of human blood-groups MN to cancer cell surface antigens and to receptors for oncogenic viruses.
Repair Defect in p21 WAF1/CIP1 -/- human cancer cells.
Replication-defective recombinant Semliki Forest virus encoding GM-CSF as a vector system for rapid and facile generation of autologous human tumor cell vaccines.
Reporter gene assay demonstrates functional differences in estrogen receptor activity in purified breast cancer cells: a pilot study.
Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth.
Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential.
S-Gal, a novel 1H MRI reporter for beta-galactosidase.
Safety, pharmacokinetics and biodistribution studies of a beta-galactoside prodrug of doxorubicin for improvement of tumor selective chemotherapy.
Secretion of extracellular superoxide dismutase from muscle transduced with recombinant adenovirus inhibits the growth of B16 melanomas in mice.
Selective astrocytic transgene expression in vitro and in vivo from the GFAP promoter in a HSV RL1 null mutant vector--potential glioblastoma targeting.
Selective gene expression in hepatic tumor with trans-arterial delivery of DNA/liposome/transferrin complex.
Selective intraarterial gene delivery into a canine meningioma.
Selective uptake of viral and monocrystalline particles delivered intra-arterially to experimental brain neoplasms.
Sequence divergence yet conserved physical characteristics among the E4 proteins of cutaneous human papillomaviruses.
Sialylation and malignant potential in tumour cell glycosylation mutants.
Simple enzyme immunoassay methods for recombinant human tumor necrosis factor alpha and its antibodies using a bacterial cell wall carrier.
Simultaneous expression of keratan sulphate epitope (a sulphated poly-N-acetyllactosamine) and blood group ABH antigens in papillary carcinomas of the human thyroid gland.
Simultaneous radiolabel, genetic tagging and proliferation assays to study the organ distribution and fate of metastatic cells.
Stable integration of an mdx skeletal muscle cell line into dystrophic (mdx) skeletal muscle: evidence for stem cell status.
Stereotactic delivery of a recombinant adenovirus into a C6 glioma cell line in a rat brain tumor model.
Studies of lectin binding to the human cervix uteri: II. Cervical intraepithelial neoplasia and invasive squamous carcinoma.
Studies of the route of administration and role of conditioning with radiation on unrelated allogeneic mismatched mesenchymal stem cell engraftment in a nonhuman primate model.
Studies on the kinetics of glycosidases from chemically-induced rat colonic tumours and normal rat colon.
Studies on variations of glycoproteins and lysosomal hydrolases in human uterine cervical carcinoma.
Study of some lysosomal glycohydrolases in tumors of the nervous system.
Successful in vivo tumor targeting of prostate-specific membrane antigen with a highly efficient J591/PEI/DNA molecular conjugate.
Suicide gene therapy using E. coli beta-galactosidase.
Suppression of human colon tumor growth by adenoviral vector-mediated NK4 expression in an athymic mouse model.
Suppression of malignant growth potentials of v-Src-transformed human gallbladder epithelial cells by adenovirus-mediated dominant negative H-Ras.
Survivin inhibits anti-growth effect of p53 activated by aurora B.
Switching on and off transgene expression within lactotrophic cells in the anterior pituitary gland in vivo.
Syn3 provides high levels of intravesical adenoviral-mediated gene transfer for gene therapy of genetically altered urothelium and superficial bladder cancer.
Synthesis and characterization of a new bioactivated paramagnetic gadolinium(III) complex [Gd(DOTA-FPG)(H2O)] for tracing gene expression.
Synthesis and enzyme-specific activation of carbohydrate-geldanamycin conjugates with potent anticancer activity.
Synthesis and evaluation of 18F- and 11C-labeled phenyl-galactopyranosides as potential probes for in vivo visualization of LacZ gene expression using positron emission tomography.
Systemic gene therapy with p53 reduces growth and metastases of a malignant human breast cancer in nude mice.
Targeted gene transfer to hepatocellular carcinoma cells in vitro using a novel monoclonal antibody-based gene delivery system.
Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum.
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins.
The activity of serum beta-galactosidase in colon cancer patients with a history of alcohol and nicotine dependence: preliminary data.
The dose dependence of glucocorticoid-inducible gene expression results from changes in the number of transcriptionally active templates.
The hemagglutinin-neuraminidase gene of Newcastle Disease Virus: a powerful molecular adjuvant for DNA anti-tumor vaccination.
The hepatitis C virus internal ribosome entry site facilitates efficient protein synthesis in blood vessel endothelium during tumour angiogenesis.
The histochemistry of glycosidases in human benign and malignant breast tissue.
The influence of oral tumor cell proliferation activity and membrane potential on the transfection efficiency of a cationic liposome.
The use of laser scanning cytometry to assess depth of penetration of adenovirus p53 gene therapy in human xenograft biopsies.
Therapeutic immune response induced by electrofusion of dendritic and tumor cells.
Trafficking of tumor peptide-specific cytotoxic T lymphocytes into the tumor microcirculation.
Transcriptionally regulated adenoviruses for prostate-specific gene therapy.
Transfection of rat ovarian surface epithelium with erb-B2/neu induces transformed phenotypes in vitro and the tumorigenic phenotype in vivo.
Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the Egr-1 promoter: activation by ionizing radiation or uptake of radioactive iododeoxyuridine.
Transgenic expression of 15-lipoxygenase 2 (15-LOX2) in mouse prostate leads to hyperplasia and cell senescence.
Treatment with hydroxyurea and tyrphostin-1 significantly improves the transduction efficiency of recombinant adeno-associated viruses in human cancer cells.
Tumor formation following murine neural precursor cell transplantation in a rat peripheral nerve injury model.
Tumor growth inhibition elicited by different vaccines and correlation with antigen specific cytotoxic T-cell frequencies determined by intracellular interferon-gamma staining.
Tumor growth reduction and DNA transfer by cavitation-enhanced high-intensity focused ultrasound in vivo.
Tumor necrosis factor inhibitor gene transfer ameliorates lung graft ischemia-reperfusion injury.
Tumor necrosis factor-alpha inhibits hTERT gene expression in human myeloid normal and leukemic cells.
Tumor suppression without differentiation or apoptosis by antisense cyclin D1 gene transfer in K1735 melanoma involves induction of p53, p21WAF1 and superoxide dismutases.
Tumor-induced interleukin-10 inhibits type 1 immune responses directed at a tumor antigen as well as a non-tumor antigen present at the tumor site.
Tumor-specific gene delivery mediated by a novel peptide-polyethylenimine-DNA polyplex targeting aminopeptidase N/CD13.
Tumor-targeted gene delivery using poly(ethylene glycol)-modified gelatin nanoparticles: in vitro and in vivo studies.
Tumor-targeted gene therapy for nasopharyngeal carcinoma.
Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis.
Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms.
Use of recombinant herpes simplex virus type 1 vectors for gene transfer into tumour and normal anterior pituitary cells.
Use of targeted cationic liposomes in enhanced DNA delivery to cancer cells.
UV-inducible base excision repair of oxidative damaged DNA in human cells.
VEGF(165), but not VEGF(189), stimulates vasculogenesis and bone marrow cell migration into Ewing's sarcoma tumors in vivo.
Viral and non-viral vectors for cancer gene therapy.
[Correlation between anti-tumor effect and delayed hypersensitivity induced by topically applied OK-432 with histological findings]
[Detection and distribution of the hydrolytic enzymes beta-D-glucuronidase, beta-D-galactosidase, beta-D-glucosidase and arylsulfatase in intracranial tumors]
[Effect of gynecologic cancer sera on functions of monocyte from healthy volunteers]
[Establishment of mouse melanoma model expressing beta-galactosidase and its application in the research of DNA vaccines against tumor]
[Gene therapy of a model of glioblastoma in rats using adenovirus vector encoding the HSVtk gene]
[Gene therapy of cerebral glioblastoma by adenovirus vector. Experimental model in the rat]
[Molecular mechanism of cell death by radiation]
[Study of GE7-transferring system mediated beta-galactosidase gene transfer in a rat model of ovarian tumor by intraarterial route]
[Synthesis of GnRH analogs and their application in targeted gene delivery systems].
Nephritis
Gene transfer into inflamed glomeruli using macrophages transfected with adenovirus.
Nephritis, Hereditary
Adenovirus-mediated gene transfer into kidney glomeruli using an ex vivo and in vivo kidney perfusion system - first steps towards gene therapy of Alport syndrome.
Nephrolithiasis
Possible biphasic changes of free radicals in ethylene glycol-induced nephrolithiasis in rats.
Nervous System Diseases
Diagnosis of feline GM1 gangliosidosis by enzyme assay of cultured conjunctival cells.
GM1-gangliosidosis (genetic beta-galactosidase deficiency): identification of four mutations in different clinical phenotypes among Japanese patients.
Molecular heterogeneity in human beta-galactosidase and neuraminidase deficiency.
Neurilemmoma
Schwannomas, benign tumors with a senescent phenotype.
[Demonstration and distribution of the enzymes: beta-D-glucuronidase, beta-D-galactosidase, beta-D-glucosidase, and arylsulfatase in neurinomas.]
Neuroblastoma
A system, using neural cell lines, to characterize HSV-1 vectors containing genes which affect neuronal physiology, or neuronal promoters.
Degree of polymerization (DP) of polysialic acid (polySia) on neural cell adhesion molecules (N-CAMS): development and application of a new strategy to accurately determine the DP of polySia chains on N-CAMS.
Early characterization of a novel metastatic disease model of murine neuroblastoma.
Ellagic acid reveals promising anti-aging effects against d-galactose-induced aging on human neuroblastoma cell line, SH-SY5Y: A mechanistic study.
Inactivation of GM1-ganglioside beta-galactosidase by a specific inhibitor: a model for ganglioside storage disease.
Poly-N-acetyllactosamine glycans of cellular glycoproteins: predominance of linear chains in mouse neuroblastoma and rat pheochromocytoma cell lines.
Retinoic acid stimulates alpha-CAMKII gene expression in PC12 cells at a distinct transcription initiation site.
Retroviral transfer of the beta-nerve growth factor gene into murine neuroectodermal tumor cells modulates cell proliferation rate, neurite formation, and NGF binding site expression.
Neurodegenerative Diseases
Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis.
GM1 gangliosidosis and Morquio B disease: expression analysis of missense mutations affecting the catalytic site of acid beta-galactosidase.
GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.
Inheritance of lysosomal acid beta-galactosidase activity and gangliosides in crosses of DBA/2J and knockout mice.
Inhibition of human P-glycoprotein transport and substrate binding using a galantamine dimer.
Molecular consequences of the pathogenic mutation in feline GM1 gangliosidosis.
Morphology of the gangliosidoses.
TDP-43 is a developmentally regulated protein essential for early embryonic development.
Neurofibrosarcoma
Schwannomas, benign tumors with a senescent phenotype.
Neurologic Manifestations
Neurological manifestations of knockout mice with beta-galactosidase deficiency.
Nevus, Pigmented
Absence of senescence-associated beta-galactosidase activity in human melanocytic nevi in vivo.
Comment on "Absence of senescence-associated beta-galactosidase activity in human melanocytic nevi in vivo".
Newcastle Disease
Resistance of native, oligomeric envelope on simian immunodeficiency virus to digestion by glycosidases.
Niemann-Pick Diseases
Electron microscopic examination of skin and conjunctival biopsy specimens in neuronal storage diseases.
Lactosyl ceramidosis: deficient activity of neutral beta-galactosidase in liver and cultivated fibroblasts?
Non-alcoholic Fatty Liver Disease
Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study.
Obesity
Analysis of osteocalcin as a candidate gene for type 2 diabetes (T2D) and intermediate traits in Caucasians and African Americans.
Onchocerciasis
Molecular cloning and characterization of recombinant parasite antigens for immunodiagnosis of onchocerciasis.
Osteoarthritis
Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation.
Osteoarthritis, Knee
Correlation between senescence-associated beta-galactosidase expression in articular cartilage and disease severity of patients with knee osteoarthritis.
Osteochondrodysplasias
Juvenile neurogenic muscle atrophy with lysosomal enzyme deficiencies: new disease or variant of mucopolysaccharidosis?
Morquio-B disease, spondyloepiphyseal dysplasia associated with acid beta-galactosidase deficiency. Report of three cases in one family.
Spondyloepiphyseal dysplasia, corneal clouding, normal intelligence and acid beta-galactosidase deficiency.
[Ophthalmologic and roentgenologic findings in a rare case of mucopolysaccharidosis 4 B]
Osteolysis
Measurement of tumor load and distribution in a model of cancer-induced osteolysis: a necessary precaution when testing novel anti-resorptive therapies.
Osteonecrosis
A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Osteoporosis
[Kcnq1ot1 promotes osteogenic differentiation and suppresses osteoclast differentiation].
Osteoporosis, Postmenopausal
Osteocalcin: genetic and physical mapping of the human gene BGLAP and its potential role in postmenopausal osteoporosis.
[Kcnq1ot1 promotes osteogenic differentiation and suppresses osteoclast differentiation].
Osteosarcoma
Effective transduction of osteogenic sarcoma cells by a baculovirus vector.
Network Pharmacology Integrated Molecular Docking Reveals the Antiosteosarcoma Mechanism of Biochanin A.
Ovarian Cysts
Increased activity of lysosomal enzymes in the peritoneal fluid of patients with gynecologic cancers and pelvic inflammatory disease.
Structural characterization of neutral oligosaccharides of human midcycle cervical mucin.
Ovarian Neoplasms
Adenovirus-based p53 gene therapy in ovarian cancer.
In vitro and in vivo adenovirus-mediated p53 and p16 tumor suppressor therapy in ovarian cancer.
Transient detection of beta-galactosidase activity in hematopoietic cells, following reinjection of retrovirally marked autologous blood progenitors in patients with breast or ovarian cancer receiving high-dose chemotherapy.
Uridine 5'-diphosphate-galactose:glycoprotein galactosyltransferase activity in the ovarian cancer patient.
Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells.
[In vitro experimental study of gene therapy for ovarian cancer with thymidine kinase gene of herpes simplex virus mediated by a non-viral GE7 delivery system]
Pancreatic Neoplasms
BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion.
Pancreatitis
Effects of acute pancreatitis on hepatic secretion of lysosomal enzymes into bile and hepatic lysosomal fragility: protective effects of a new synthetic protease inhibitor, ONO 3307.
Serum beta-N-acetylglucosaminidase, beta-D-glucosidase, alpha-D-glucosidase, beta-D-fucosidase, alpha-L-fucosidase and beta-D-galactosidase levels in acute viral hepatitis, pancreatitis, myocardial infarction and breast cancer.
Treatment of Inflamed Pancreas with Enkephalin Encoding HSV-1 Recombinant Vector Reduces Inflammatory Damage and Behavioral Sequelae.
Pancreatitis, Chronic
BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion.
Papilloma
Expression profile of senescence-associated beta-galactosidase and activation of telomerase in human ovarian surface epithelial cells undergoing immortalization.
Expression vector with DNA of bovine papilloma virus 1 for keratinocyte gene therapy.
Priming of cytotoxic T lymphocytes by five heat-aggregated antigens in vivo: conditions, efficiency, and relation to antibody responses.
Studies of the activities of lysosomal enzymes in serum and buccal pouch tissue of hamsters during 7,12-dimethylbenz[a]anthracene-induced carcinogenesis.
[Transcriptional inhibition of human papilloma virus in cervical carcinoma cells reactivates functions of the tumor suppressor p53]
Paratuberculosis
Expression of Escherichia coli beta-galactosidase in Mycobacterium bovis BCG using an expression system isolated from Mycobacterium paratuberculosis which induced humoral and cellular immune responses.
Parotitis
[The lysosomal hydrolase activity in the blood of patients with inflammatory processes in the parotid gland with surgical pathology of the organs of the abdominal cavity]
Pelvic Inflammatory Disease
Increased activity of lysosomal enzymes in the peritoneal fluid of patients with gynecologic cancers and pelvic inflammatory disease.
Peri-Implantitis
The pathology of bone tissue during peri-implantitis.
Periodontitis
Glycosidase activities in gingival crevicular fluid in subjects with adult periodontitis or gingivitis.
Impairment of osteocalcin production in senescent periodontal ligament fibroblasts.
[Enzymatic protective systems of saliva in inflammation of the periodontium]
Peritonitis
Gene therapy utilizing the Cre/loxP system selectively suppresses tumor growth of disseminated carcinoembryonic antigen-producing cancer cells.
Increased activity of lysosomal enzymes in the peritoneal fluid of bacterial peritonitis.
Persistent Infection
[Persistent infection of bacteriophage. 4. One-step growth of MS 2 phage and its extracellular excretion of beta-galactosidase in the two clones of E. coli Hfr Ci-1 and -n]
Pheochromocytoma
A system, using neural cell lines, to characterize HSV-1 vectors containing genes which affect neuronal physiology, or neuronal promoters.
Autocrine differentiation of PC12 cells mediated by retroviral vectors.
Enhancement of beta-galactosidase gene expression in rat pheochromocytoma cells by exposure to extremely low frequency magnetic fields.
Induction of orthotopic rat adrenomedullary neoplasia by intraadrenal pheochromocytoma cell transplantation.
Myogenic conversion of mammalian fibroblasts induced by differentiating muscle cells.
Poly(N-acetyllactosaminyl) oligosaccharides in glycoproteins of PC12 pheochromocytoma cells and sympathetic neurons.
Poly-N-acetyllactosamine glycans of cellular glycoproteins: predominance of linear chains in mouse neuroblastoma and rat pheochromocytoma cell lines.
Retinoic acid stimulates alpha-CAMKII gene expression in PC12 cells at a distinct transcription initiation site.
Retroviral transfer of the beta-nerve growth factor gene into murine neuroectodermal tumor cells modulates cell proliferation rate, neurite formation, and NGF binding site expression.
Specific binding of glycosylated beta-galactosidase to rat clonal pheochromocytoma PC12h cells: effects of nerve growth factor and gangliosides.
Pituitary Neoplasms
In vitro and in vivo herpetic vector-mediated gene transfer in the pituitary gland: impact on hormone secretion.
Studies on in vivo gene transfer in pituitary tumors using herpes-derived and adenoviral vectors.
Pleural Effusion
Diagnostic potential of lysosomal hydrolases in body cavity effusions.
Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury.
Pneumonia
Effects of bronchopulmonary inflammation induced by pseudomonas aeruginosa on adenovirus-mediated gene transfer to airway epithelial cells in mice.
Gene therapy with lipopolysaccharide binding protein for gram-negative pneumonia: respiratory physiology.
Improved survival in mice given systemic gene therapy in a gram negative pneumonia model.
Poliomyelitis
beta-Galactosidase containing a human immunodeficiency virus protease cleavage site is cleaved and inactivated by human immunodeficiency virus protease.
Polycystic Kidney, Autosomal Dominant
Functional defects in lysosomal enzymes in autosomal dominant polycystic kidney disease (ADPKD): abnormalities in synthesis, molecular processing, polarity, and secretion.
Pre-Eclampsia
Endoplasmic reticulum stress disrupts lysosomal homeostasis and induces blockade of autophagic flux in human trophoblasts.
Prolactinoma
Studies on in vivo gene transfer in pituitary tumors using herpes-derived and adenoviral vectors.
Prostatic Hyperplasia
Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia.
Transgenic expression of 15-lipoxygenase 2 (15-LOX2) in mouse prostate leads to hyperplasia and cell senescence.
Prostatic Neoplasms
Adenovirus-mediated suicide-gene therapy using the herpes simplex virus thymidine kinase gene in cell and animal models of human prostate cancer: changes in tumour cell proliferative activity.
Alterations in PMS2, MSH2 and MLH1 expression in human prostate cancer.
Beta-galactosidase as a marker of HSP70 promoter induction in Dunning R3327 prostate carcinoma cells.
Demonstration of a rational strategy for human prostate cancer gene therapy.
Development of a high-efficiency method for gene marking of Dunning prostate cancer cell lines with the enzyme beta-galactosidase.
In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug.
Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence.
Tissue transglutaminase interacts with protein kinase A anchor protein 13 in prostate cancer.
Protein-Energy Malnutrition
Lysosomal enzymuria in protein energy malnutrition.
Proteinuria
Changes in lysosome populations in the rat kidney cortex induced by passive Heymann glomerulonephritis.
Effect of aging on gentamicin nephrotoxicity and pharmacokinetics in rats.
Pseudorabies
A glycoprotein gX-beta-galactosidase fusion gene as insertional marker for rapid identification of pseudorabies virus mutants.
beta-Galactosidase expressing recombinant pseudorabies virus for light and electron microscopic study of transneuronally labeled CNS neurons.
Central autonomic control of the bone marrow: multisynaptic tract tracing by recombinant pseudorabies virus.
CNS cell groups projecting to the submandibular parasympathetic preganglionic neurons in the rat: a retrograde transneuronal viral cell body labeling study.
Dendritic morphology of cardiac related medullary neurons defined by circuit-specific infection by a recombinant pseudorabies virus expressing beta-galactosidase.
Expression of three recombinant proteins using baculovirus vectors in 23 insect cell lines.
Identification of lumbar spinal neurons controlling simultaneously the prostate and the bulbospongiosus muscles in the rat.
Propagation of pseudorabies virus in the nervous system of the mouse after intranasal inoculation.
Pseudorabies virus-based gene delivery to rat embryonic spinal cord grafts.
Rapid identification and quantitation of cells infected by recombinant herpesvirus (pseudorabies virus) using a fluorescence-based beta-galactosidase assay and flow cytometry.
TLR9 pathway is involved in adjuvant effects of plasmid DNA-based vaccines.
Pulmonary Fibrosis
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix.
Reflex, Abnormal
Juvenile neurogenic muscle atrophy with lysosomal enzyme deficiencies: new disease or variant of mucopolysaccharidosis?
Relative Energy Deficiency in Sport
Developmental expression of a type II collagen/beta-galactosidase fusion gene in transgenic mice.
MiR-486-3p promotes osteogenic differentiation of BMSC by targeting CTNNBIP1 and activating the Wnt/?-catenin pathway.
Sustainable aquaculture side-streams derived hybrid biocomposite for bone tissue engineering.
Transcriptome-wide m6A methylome during osteogenic differentiation of human adipose-derived stem cells.
Reperfusion Injury
Beta-galactosidase as a marker of ischemic injury and a mechanism for viability assessment in porcine liver transplantation.
Retinal Degeneration
An immune response after intraocular administration of an adenoviral vector containing a beta galactosidase reporter gene slows retinal degeneration in the rd mouse.
Characterization of Wnt signaling during photoreceptor degeneration.
GM1 gangliosidosis type 2 in two siblings.
Immune consequences of intraocular administration of modified adenoviral vectors.
Retinoblastoma
A melanoma cell line sensitive to expression of a fusion protein binding the retinoblastoma protein family pocket domain.
Estrogen receptor alpha inhibits senescence-like phenotype and facilitates transformation induced by oncogenic ras in human mammary epithelial cells.
Ha-Ras(G12V) induces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction.
Indoxyl sulfate induces nephrovascular senescence.
Indoxyl sulfate, a uremic toxin, promotes cell senescence in aorta of hypertensive rats.
Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts.
Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer.
The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program.
The expression of the retinoblastoma gene product Rb1 in primary and adenovirus-transformed human cells.
Use of a retroviral vector with an internal opsin promoter to direct gene expression to retinal photoreceptor cells.
Retroviridae Infections
Gene transfer of lacZ into avian neural tube and neural crest cells by retroviral infection of grafted embryonic tissues.
Rhinitis
ELISA in diagnosis of respiratory allergy. A comparison with RAST and skin tests.
Rubella
Recombinant rubella E1 fusion proteins for antibody screening and diagnosis.
Sarcoidosis
Spontaneous hydrogen peroxide release from alveolar macrophages of patients with active sarcoidosis: comparison with cigarette smokers.
Sarcoma
1998 ARRS President's Award. The potential of in vivo vascular tissue engineering for the treatment of vascular thrombosis: a preliminary report. American Roentgen Ray Society.
Activity assays of nine heterogeneous promoters in neural and other cultured cells.
Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells.
Adenovirus-mediated suicide gene therapy for experimental bladder cancer.
Efficient incorporation of transfected blastodermal cells into chimeric chicken embryos.
Myeloproliferative sarcoma virus directed expression of beta-galactosidase following retroviral transduction of murine hematopoietic cells.
Rapid characterization of growth-arrest genes in transient transfection assays.
Retargeting of viral vectors to the folate receptor endocytic pathway.
Transcriptional regulation of a contractile gene by mechanical forces applied through integrins in osteoblasts.
Viral interference during simultaneous transduction with two independent helper-free retroviral vectors.
[Analysis of expression of the RSV-lacZ-gene in transgenic embryos of the loach Misgurnus fossilis L. during different variations of injection]
Sarcoma, Avian
A transgene containing lacZ is expressed in primary sensory neurons in zebrafish.
Activity assays of nine heterogeneous promoters in neural and other cultured cells.
Adenoviral vector as a gene delivery system into cultured rat neuronal and glial cells.
Adenovirus-mediated gene transfer during initial organogenesis in the mammalian embryo is promoter-dependent and tissue-specific.
Adenovirus-mediated gene transfer in vivo to cerebral blood vessels and perivascular tissue in mice.
Adenovirus-mediated gene transfer is augmented in basilar and carotid arteries of heritable hyperlipidemic rabbits.
Adenovirus-mediated gene transfer to cultured nodose sensory neurons.
Adenovirus-mediated transgene expression in nonhuman primate brain.
Bacterial beta-galactosidase as a marker of Rous sarcoma virus gene expression and replication.
Baculovirus-mediated expression of bacterial genes in dipteran and mammalian cells.
Biodegradable alginate microspheres as a delivery system for naked DNA.
Calcium phosphate transfection and cell-specific expression of heterologous genes in primary fetal rat hepatocytes.
Characterization of Rous sarcoma virus sequences essential for viral gene expression.
Characterization of the nuclear localization signal in the avian sarcoma virus integrase.
Construction of plasmids for expression of Rous sarcoma virus transforming protein, p60src, in Escherichia coli.
Control of insulin gene expression by glucose.
Delivery of adenoviral vectors to the prostate for gene therapy.
Efficient gene transfer into nondividing cells by adeno-associated virus-based vectors.
Engineering ex vivo-expanded marrow stromal cells to secrete calcitonin gene-related peptide using adenoviral vector.
Evaluation of promoter strength in mouse and rat primary hepatocytes using adenovirus vectors.
Evidence for positive and negative regulation in the promoter of the chicken delta 1-crystallin gene.
Expression from cardiomyocyte-specific promoter after adenovirus-mediated gene transfer in vitro and in vivo.
Expression of recombinant genes in myocardium in vivo after direct injection of DNA.
Gene delivery to spinal motor neurons.
Gene expression after intrarenal injection of plasmid DNA in the rat.
Gene transfer to the human trabecular meshwork by anterior segment perfusion.
Generation of an adenovirus vector lacking E1, e2a, E3, and all of E4 except open reading frame 3.
In vitro assessment of variables affecting the efficiency and efficacy of adenovirus-mediated gene transfer to cystic fibrosis airway epithelia.
In vivo adenovirus-mediated suicide gene therapy of orthotopic bladder cancer.
In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy.
Infection efficiency of human and mouse embryonic stem cells using adenoviral and adeno-associated viral vectors.
Isolation of antibodies specific for avian viral and cellular myc proteins.
Liposome-mediated gene transfer to fetal human ventral mesencephalic explant cultures.
Myocardial gene transfer by selective pressure-regulated retroinfusion of coronary veins.
Neuroprotection of spinal motoneurons following targeted transduction with an adenoviral vector carrying the gene for glial cell line-derived neurotrophic factor.
Phase I study of a recombinant adenovirus-mediated gene transfer in lung cancer patients.
Polycation-DNA complexes for gene delivery: a comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids.
Transactivation of the early SV40 promoter by avian infectious laryngotracheitis virus in avian hepatoma cells.
[Expression of the CMV-lacZ- and RSV-lacZ-genes in transgenic fish and mouse embryos]
Scleroderma, Diffuse
Origin of the enhanced activity of lysosomal beta-galactosidase in serum and skin in progressive systemic sclerosis.
[Effect of penicillin and D-penicillamine on beta-galactosidase activity in patients with progressive scleroderma]
[N-procollagen(III)peptide and lysosomal beta-galactosidase in progressive scleroderma and silicosis]
Scleroderma, Systemic
Type III collagen aminopropeptide and laminin P1 levels in serum of patients with silicosis-associated and idiopathic systemic scleroderma.
[Beta-Galactosidase activity in serum of systemic sclerosis (author's transl)]
Scoliosis
Senescence in human intervertebral discs.
Scrapie
Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: in vivo comparison of distinct GFAP-lacZ transgenes.
Seizures
Adult GM1 gangliosidosis: clinical and biochemical studies on two patients and comparison to other patients called variant or adult GM1 gangliosidosis.
Attenuation of seizure in P77PMC rats with an HSV-vector expressing IL-1ra in brain.
Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver.
Overexpression of GluR6 in rat hippocampus produces seizures and spontaneous nonsynaptic bursting in vitro.
Sepsis
Highly increased levels of serum beta-hexosaminidase, arylsulphatase A and beta-galactosidase in a patient with sepsis.
Tumour necrosis factor-alpha causes an increase in blood-brain barrier permeability during sepsis.
Severe Combined Immunodeficiency
The map of chromosome 20.
Sialadenitis
Effect of human vasoactive intestinal peptide gene transfer in a murine model of Sjogren's syndrome.
Silicosis
[Early detection of scleroderma in quartz dust exposed workers and workers with silicosis by determining serum beta-galactosidase activity]
[N-procollagen(III)peptide and lysosomal beta-galactosidase in progressive scleroderma and silicosis]
Silicotuberculosis
Histoenzymology of the lung. II. The behaviour of lung hydrolytic enzymes during some experimental pulmonary processes.
Sleep Deprivation
Sleep deprivation increases the activation of nuclear factor kappa B in lateral hypothalamic cells.
Sphingolipidoses
Lactosylceramide beta-galactosidase in human sphingolipidoses. Evidence for two genetically distinct enzymes.
Sphingolipidoses in Turkey.
Spinal Cord Injuries
In vivo Bcl-2 oncogene neuronal expression in the rat spinal cord.
Spinocerebellar Ataxias
USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product.
Spondylolisthesis
Senescence in human intervertebral discs.
Squamous Cell Carcinoma of Head and Neck
Evaluation of topical gene therapy for head and neck squamous cell carcinoma in an organotypic model.
Head and neck cancer cells are efficiently infected by Ad5/35 hybrid virus.
Interference with the bromodomain epigenome readers drives p21 expression and tumor senescence.
Suicide gene therapy for human oral squamous cell carcinoma cell lines with adeno-associated virus vector.
Starvation
A global analysis of developmentally regulated genes in Myxococcus xanthus.
A second protein disulfide isomerase plays a protective role against nitrosative and nutritional stresses in Schizosaccharomyces pombe.
ADHII in Aspergillus nidulans is induced by carbon starvation stress.
Analysis of teichoic acid biosynthesis regulation reveals that the extracytoplasmic function sigma factor sigmaM is induced by phosphate depletion in Bacillus subtilis W23.
beta-Galactosidase activity of Escherichia coli under long-term starvation, alterations in temperature, and different nutrient conditions in lake water.
Cell cycle regulation of the Escherichia coli nrd operon: requirement for a cis-acting upstream AT-rich sequence.
Cell-cycle-dependent sorting in the development of Dictyostelium cells.
Characterization of the carbon starvation-inducible and stationary phase-inducible gene slp encoding an outer membrane lipoprotein in Escherichia coli.
Characterization of the regulatory region of a cell interaction-dependent gene in Myxococcus xanthus.
Cloning, characterization and regulation of a protein disulfide isomerase from the fission yeast Schizosaccharomyces pombe.
Control of protein synthesis in Escherichia coli: strain differences in control of translational initiation after energy source shift-down.
Decay of RNA in RNA processing mutants of Escherichia coli.
Differential regulation by cyclic AMP of starvation protein synthesis in Escherichia coli.
Effect of u.v. light irradiation, starvation and heat on Escherichia coli beta-D-galactosidase activity and other potential viability parameters.
Effects of starvation for exogenous carbon on functional mRNA stability and rate of peptide chain elongation in Escherichia coli.
Erythromycin, lincosamides, peptidyl-tRNA dissociation, and ribosome editing.
Escherichia coli ferric uptake regulator (Fur) can mediate regulation of a pseudomonad iron-regulated promoter.
Formation of the LuxR protein in the Vibrio fischeri lux system is controlled by HtpR through the GroESL proteins.
Glycosyl hydrolases of cell wall are induced by sugar starvation in Arabidopsis.
Identification and characterization of a relA-dependent starvation-inducible locus (sin) in Salmonella typhimurium.
Identification of sulfate starvation-regulated genes in Escherichia coli: a gene cluster involved in the utilization of taurine as a sulfur source.
Identification of the omega4400 regulatory region, a developmental promoter of Myxococcus xanthus.
Isolation and characterization of a mutant defective in triacylglycerol accumulation in nitrogen-starved Chlamydomonas reinhardtii.
Mis-transcription during uridine starvation in Escherichia coli K12.
Molecular cloning, characterization and regulation of a peroxiredoxin gene from Schizosaccharomyces pombe.
Mutagenesis of Erwinia carotovora subsp. carotovora with bacteriophage Mu d1 (Apr lac cts62): construction of his-lac gene fusions.
Posttranscriptional regulation of FLO11 upon amino acid starvation in Saccharomyces cerevisiae.
Preferential synthesis of beta-galactosidase after amino acid starvation.
Proline biosynthesis in Saccharomyces cerevisiae: molecular analysis of the PRO1 gene, which encodes gamma-glutamyl kinase.
Protective role and regulation of Rad9 from the fission yeast Schizosaccharomyces pombe.
Protective roles and Pap1-dependent regulation of the Schizosaccharomyces pombe spy1 gene under nitrosative and nutritional stresses.
Response of heterogenous rat liver lysosome populations to starvation and refeeding.
Screening and characterization of transposon-insertion mutants in a pseudohyphal strain of Saccharomyces cerevisiae.
Stabilization of a HemA-LacZ hybrid protein against proteolysis during carbon starvation in atp mutants of Salmonella typhimurium.
Starvation stress modulates the expression of the Aspergillus nidulans brlA regulatory gene.
Synthesis of beta-galactosidase messenger RNA during amino acid starvation of stringent and relaxed strains of Escherichia coli.
Synthesis of inactive beta-galactosidase during amino acid starvation in Escherichia coli K-12.
Synthesis of inducible enzyme in Escherichia coli recovering from prolonged energy starvation.
The gene encoding gamma-glutamyl transpeptidase II in the fission yeast is regulated by oxidative and metabolic stress.
The pap1(+) gene of fission yeast is transcriptionally regulated by nitrosative and nutritional stress.
The regulatory control of the bacterial luminescence system--a new view.
Three regulatory systems control expression of glutamine synthetase in Saccharomyces cerevisiae at the level of transcription.
Thymine starvation and beta-galactosidase synthesis.
Transcription of ppk from Acinetobacter sp. strain ADP1, encoding a putative polyphosphate kinase, is induced by phosphate starvation.
Transport of 5-aminolevulinic acid by the dipeptide permease in Salmonella typhimurium.
Unusual stability and translation kinetics of an Escherichia coli lac messenger RNA synthetized during amino-acids deprivation.
Use of glucose starvation to limit growth and induce protein production in Escherichia coli.
[Salmonella identification after incubation in the soil]
Stomach Neoplasms
In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma.
Stomach Ulcer
[Immunohistochemical studies on non neoplastic and neoplastic gastric mucosa. Determination of embryonic and specific antigens (author's transl)]
Stomatitis
Dose-dependent transduction of vesicular stomatitis virus G protein-pseudotyped retrovirus vector into human solid tumor cell lines and murine fibroblasts.
Subacute Sclerosing Panencephalitis
Regulation of expression of genes coding for small, acid-soluble proteins of Bacillus subtilis spores: studies using lacZ gene fusions.
Superinfection
A gene delivery/recall system for neurons which utilizes ribonucleotide reductase-negative herpes simplex viruses.
A novel type of dimerization motif, related to leucine zippers, is present in plant homeodomain proteins.
Complex structure of the nuclear translocation signal of influenza virus polymerase PA subunit.
Generation of high-titer defective HSV-1 vectors using an IE 2 deletion mutant and quantitative study of expression in cultured cortical cells.
Long-term expression in sensory neurons in tissue culture from herpes simplex virus type 1 (HSV-1) promoters in an HSV-1-derived vector.
pEMBL: a new family of single stranded plasmids.
Quiescent viral genomes in human fibroblasts after infection with herpes simplex virus type 1 Vmw65 mutants.
Translational polarity of a mutation in the initiator AUG codon of the lambda cI gene.
Tay-Sachs Disease
Electron microscopic examination of skin and conjunctival biopsy specimens in neuronal storage diseases.
Lymphoblastoid cell lines, transformed by Epstein-Barr virus, in the enzymatic study of hereditary lysosomal storage diseases.
Teratocarcinoma
Cloning and characterization of 5'-upstream sequence of the M32 gene for a mouse homologue of Drosophila heterochromatin protein 1 (HP1).
Direct visualization, by beta-galactosidase histochemistry, of differentiated normal cells derived from malignant teratocarcinoma in allophenic mice.
Expression of the lacZ gene targeted to the HPRT locus in embryonic stem cells and their derivatives.
Packaging of endogenous retroviral sequences in retroviral vectors produced by murine and human packaging cells.
The linear tetrasaccharide, Gal beta 1-4GlcNAc beta 1-6Gal beta 1-4GlcNAc, isolated from radiolabeled teratocarcinoma poly-N-acetyllactosaminoglycan resists the action of E. freundii endo-beta-galactosidase.
Tetanus
Brain-derived neurotrophic factor facilitates in vivo internalization of tetanus neurotoxin C-terminal fragment fusion proteins in mature mouse motor nerve terminals.
C fragment of tetanus toxin hybrid proteins evaluated for muscle-specific transsynaptic mapping of spinal motor circuitry in the newborn mouse.
Fragment C tetanus toxin: a putative activity-dependent neuroanatomical tracer.
Inducible expression of retrograde transynaptic genetic tracer in mice.
Leaky Lactococcus cultures that externalize enzymes and antigens independently of culture lysis and secretion and export pathways.
Secretion from bovine chromaffin cells acutely expressing exogenous proteins using a recombinant Semliki Forest virus containing an EGFP reporter.
Structure of the VH and VL segments of polyreactive and monoreactive human natural antibodies to HIV-1 and Escherichia coli beta-galactosidase.
Thrombosis
1998 ARRS President's Award. The potential of in vivo vascular tissue engineering for the treatment of vascular thrombosis: a preliminary report. American Roentgen Ray Society.
Adenovirus-mediated transfer of beta-galactosidase and prourokinase genes into vein grafts.
Local gene delivery: arterial thrombosis model for endothelial cell-targeted thrombolytic gene therapy research.
Thrombus generation after adenovirus-mediated gene transfer into atherosclerotic arteries.
Thyroid Neoplasms
Adenoviral infection of thyroid cells: a rationale for gene therapy for metastatic thyroid carcinoma.
Cell-specific induction of sensitivity to ganciclovir in medullary thyroid carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase.
Histochemical demonstration and analysis of poly-N-acetyllactosamine structures in normal and malignant human tissues.
Histochemical demonstration of different types of poly-N-acetyllactosamine structures in human thyroid neoplasms using lectins and endo-beta-galactosidase digestion.
Thyroiditis
Antibodies reactive with an intracellular epitope of a recombinant 64 kDa thyroid and eye muscle protein in patients with thyroid autoimmunity and ophthalmopathy.
Tremor
Adenoviral gene transfer of aspartoacylase into the tremor rat, a genetic model of epilepsy, as a trial of gene therapy for inherited epileptic disorder.
Tuberculosis
Analysis of the shotgun expression library of the Mycobacterium tuberculosis genome for immunodominant polypeptides: potential use in serodiagnosis.
Histoenzymology of the lung. II. The behaviour of lung hydrolytic enzymes during some experimental pulmonary processes.
Identification and characterization of rel promoter element of Mycobacterium tuberculosis.
Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin.
Regulation of the expression of whiB1 in Mycobacterium tuberculosis: role of cAMP receptor protein.
T cell responses of normal individuals towards recombinant protein antigens of Mycobacterium tuberculosis.
[Chronorogical changes in activities of various enzymes including beta-galactosidase and naphthol AS-D acetate esterase of the mononuclear phagocytes in tuberculosis lesions (author's transl)]
Tyrosinemias
Cellular senescence in livers from children with end stage liver disease.
Urinary Bladder Neoplasms
Adenoviral p53 gene transfer in human bladder cancer cell lines: cytotoxicity and synergy with cisplatin.
An improved intravesical model using human bladder cancer cell lines to optimize gene and other therapies.
Intravesical liposome-mediated interleukin-2 gene therapy in orthotopic murine bladder cancer model.
Role of urinary beta-glucuronidase in human bladder cancer.
Tumor-specific gene delivery mediated by a novel peptide-polyethylenimine-DNA polyplex targeting aminopeptidase N/CD13.
Urolithiasis
Increased urinary excretion of renal enzymes in idiopathic calcium oxalate nephrolithiasis.
Uterine Cervical Neoplasms
Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer.
Uveitis
Chronic uveitis in guinea pigs infected with varicella-zoster virus expressing Escherichia coli beta-galactosidase.
Vaccinia
A consideration of previously uncharacterized fowl poxvirus unidirectional and bidirectional late promoters for inclusion in homologous recombinant vaccines.
A vaccinia virus vector for efficiently introducing into hippocampal slices.
Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor-associated antigen.
Anti-tumor activity of cytotoxic T lymphocytes elicited with recombinant and synthetic forms of a model tumor-associated antigen.
Antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor vaccine.
Antigen-specific tumor vaccine efficacy in vivo against prostate cancer with low class I MHC requires competent class II MHC.
Antitumor efficacy of tumor-antigen-encoding recombinant poxvirus immunization in Dunning rat prostate cancer: implications for clinical genetic vaccine development.
Beta galactosidase release as an alternative to chromium release in cytotoxic T-cell assays.
Characterization of the varicella-zoster virus gene 61 protein.
Comparative analysis of the conserved region of the orthopoxvirus genome encoding the 36K and 12K proteins.
Construction and characterization of a triple-recombinant vaccinia virus encoding B7-1, interleukin 12, and a model tumor antigen.
Construction of fowlpox virus vectors with intergenic insertions: expression of the beta-galactosidase gene and the measles virus fusion gene.
Costimulation enhances the active immunotherapy effect of recombinant anticancer vaccines.
Delineation of the viral products of recombination in vaccinia virus-infected cells.
Early gene expression of vaccinia virus strains replicating (Praha) and non-replicating (modified vaccinia virus strain Ankara, MVA) in mammalian cells.
Endothelial cells present antigens in vivo.
Engulfment of apoptotic cells expressing HCV proteins leads to differential chemokine expression and STAT signaling in human dendritic cells.
Flow cytometric quantitation of the protective efficacy of dendritic cell based vaccines in a human papillomavirus type 16 murine challenge model.
Gender effects on humoral immune responses to smallpox vaccine.
Gene delivery by viral vectors in primary cultures of lacrimal gland tissue.
Gene transfer by viral vectors into blood vessels in a rat model of retinopathy of prematurity.
Gene transfer into the mammalian inner ear using HSV-1 and vaccinia virus vectors.
Gene transfer mediated by different viral vectors following direct cannulation of mouse submandibular salivary glands.
High level protein expression in mammalian cells using a safe viral vector: Modified vaccinia virus Ankara.
High-level expression of Amsacta moorei entomopoxvirus spheroidin depends on sequences within the gene.
Highly efficient expression of proteins encoded by recombinant vaccinia virus in lymphocytes.
Host range selection of vaccinia recombinants containing insertions of foreign genes into non-coding sequences.
IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines: enhancement by simultaneous B7-1 expression.
Interleukin-10 enhances the therapeutic effectiveness of a recombinant poxvirus-based vaccine in an experimental murine tumor model.
Intracellular rate-limiting steps in MHC class I antigen processing.
Measles virus and canine distemper virus target proteins into a TAP-independent MHC class I-restricted antigen-processing pathway.
Monitoring of human immunological responses to vaccinia virus.
Novel oncolytic agent GLV-1h68 is effective against malignant pleural mesothelioma.
Quantitative assessment of poxvirus promoters in fowlpox and vaccinia virus recombinants.
Recombinant vaccinia expressing interleukin-2 for cancer gene therapy.
Recombinant vaccinia virus expressing cytokine GM-CSF as tumor vaccine.
Reintroduction of gene(s) into an attenuated deletion mutant of vaccinia virus strain IHD-W.
Selection of recombinant vaccinia viruses (Tian Tan strain) expressing hepatitis B virus surface antigen by using beta-galactosidase as a marker.
Selective humoral immune response of Balb/C mice to Brucella abortus proteins expressed by vaccinia virus recombinants.
Solid tissues can be manipulated ex vivo and used as vehicles for gene therapy.
Statistical approach to estimate vaccinia-specific neutralizing antibody titers using a high-throughput assay.
Stringent chemical and thermal regulation of recombinant gene expression by vaccinia virus vectors in mammalian cells.
Structure of vaccinia virus early promoters.
Structure of vaccinia virus late promoters.
Targeting of vaccinia virus using biotin-avidin viral coating and biotinylated antibodies.
The 5' noncoding region sequence of the Choristoneura biennis entomopoxvirus spheroidin gene functions as an efficient late promoter in the mammalian vaccinia expression system.
The amino terminus of the adenovirus fiber protein encodes the nuclear localization signal.
The gene encoding the late nonstructural 36K protein of vaccinia virus is essential for virus reproduction.
Transfer of the inducible lac repressor/operator system from Escherichia coli to a vaccinia virus expression vector.
Treatment of anaplastic thyroid carcinoma in vitro with a mutant vaccinia virus.
Tumor growth inhibition elicited by different vaccines and correlation with antigen specific cytotoxic T-cell frequencies determined by intracellular interferon-gamma staining.
Tumor-induced interleukin-10 inhibits type 1 immune responses directed at a tumor antigen as well as a non-tumor antigen present at the tumor site.
Use of GLV-1h68 for Vaccinia Virotherapy and Monitoring.
Vaccinia as a tool for functional analysis in regenerating limbs: ectopic expression of Shh.
Vaccinia virus encodes a polypeptide with DNA ligase activity.
Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques.
Vaccinia virus recombinants expressing an 11-kilodalton beta-galactosidase fusion protein incorporate active beta-galactosidase in virus particles.
Vaccinia virus vectors utilizing the beta-galactosidase assay for rapid selection of recombinant viruses and measurement of gene expression.
Viable double vaccinia virus recombinants with the non-inducible phage T7 expression system.
[Analysis of reporter gene expression at different segments of the vaccinia virus genome]
[Expression of beta-galactosidase in recombinant nonintegrated plasmids in evaluating the functional activity of vaccinia virus promoters]
[Expression of the glow worm luciferase gene in mammalian cells using vectors based on vaccinia viruses]
[Insertion mutants of the vaccinia virus. The effect of inactivating E7R and D8L genes on the biological properties of the virus]
[Mapping of "nonessential" regions in the genome of vaccinia virus]
[Methods of isolating and selecting recombinant vaccinia viruses expressing heterogenetic viral antigens]
[Molecular biological study of the vaccinia virus genome. IV. The late nonstructural 36K protein of vaccinia virus is vitally important]
[Quantitative analysis of cell fusion caused by glycoprotein of paramyxoviruses with reporter gene method]
Varicocele
Abnormal expression of acid glycosidases in seminal plasma and spermatozoa from infertile men with varicocele.
Varicose Ulcer
The effect of passage number on fibroblast cellular senescence in patients with chronic venous insufficiency with and without ulcer.
Venous ulcer fibroblasts respond to basic fibroblast growth factor at the cell cycle protein level.
Vascular Calcification
The effects of hyperuricemia on the differentiation and proliferation of osteoblasts and vascular smooth muscle cells are implicated in the elevated risk of osteopenia and vascular calcification in gout: An in vivo and in vitro analysis.
Vascular Diseases
Cytochemical detection of a senescence-associated beta-galactosidase in endothelial and smooth muscle cells from human and rabbit blood vessels.
Enzymes and cytomorphological sperm alterations in some diseases of the male reproductive system.
Vascular Ring
Ex vivo gene transfer of endothelial nitric oxide synthase to atherosclerotic rabbit aortic rings improves relaxations to acetylcholine.
Vascular System Injuries
In vivo gene transfer: prevention of neointima formation by inhibition of mitogen-activated protein kinase kinase.
Selective neointimal gene transfer in an avian model of vascular injury.
Stress-induced Senescence Exaggerates Post Injury Neointimal Formation in the Old Vasculature.
Vesicular Stomatitis
Feasibility of retroviral vector-mediated in utero gene transfer to the fetal rabbit.
Gene transfer to the nonhuman primate retina with recombinant feline immunodeficiency virus vectors.
Involvement of carbohydrates in vesicular stomatitis virus-cell early interaction.
Noncytopathic flavivirus replicon RNA-based system for expression and delivery of heterologous genes.
Optimization of human erythropoietin secretion from MLV-infected human primary fibroblasts used for encapsulated cell therapy.
Retrovirus-mediated transduction of porcine keratinocytes in organ culture.
Role of hepatocyte direct hyperplasia in lentivirus-mediated liver transduction in vivo.
Transduction of cultured fish cells with recombinant baculoviruses.
Virus Diseases
5' sequence of vesicular stomatitis virus N-gene confers selective translation of mRNA.
Adeno-associated virus-mediated osteoprotegerin gene transfer protects against particulate polyethylene-induced osteolysis in a murine model.
Characterization of SA-11 rotavirus receptorial structures on human colon carcinoma cell line HT-29.
Contribution of the C-terminal tri-lysine regions of human immunodeficiency virus type 1 integrase for efficient reverse transcription and viral DNA nuclear import.
Dominant negative Rab3D inhibits amylase release from mouse pancreatic acini.
Effects of baculovirus infection on IE1-mediated foreign gene expression in stably transformed insect cells.
Isolation and Characterization of Pepper Genes Interacting with the CMV-P1 Helicase Domain.
Long-term promoter activity during herpes simplex virus latency.
Migration of virus-infected neuronal cells in cerebral slice cultures of developing mouse brains after in vitro infection with murine cytomegalovirus.
Pretreatment with protease is a useful experimental strategy for enhancing adenovirus-mediated cancer gene therapy.
Reduction of type V collagen using a dominant-negative strategy alters the regulation of fibrillogenesis and results in the loss of corneal-specific fibril morphology.
Replication-defective virus infection of feather buds produces a localized region of beta-galactosidase activity.
Role of membrane phospholipids and glycolipids in the Vero cell surface receptor for rubella virus.
Signalling mechanisms in contraction-mediated stimulation of intracellular NO production in cat ventricular myocytes.
Significant increase in recombinant protein production of a virus-infected Sf-9 insect cell culture of low MOI under low dissolved oxygen conditions.
Superinfection prevents recombination of the alphaherpesvirus bovine herpesvirus 1.
Transactivation of the early SV40 promoter by avian infectious laryngotracheitis virus in avian hepatoma cells.
Tricyclo-DNA containing oligonucleotides as steric block inhibitors of human immunodeficiency virus type 1 tat-dependent trans-activation and HIV-1 infectivity.
Use of recombinant herpes simplex virus type 1 vectors for gene transfer into tumour and normal anterior pituitary cells.
[Using reporter gene to compare infection efficiency of HIV-1 pseudovirus to suspended and adherent cells].
Vitamin A Deficiency
Histochemical studies on the salivary glands in white rats in vitamin A deficiency. I. Beta-glucuronidase and beta-galactosidase in secretory cells of the sublingual and submandibular glands.
Werner Syndrome
No increase in senescence-associated beta-galactosidase activity in Werner syndrome fibroblasts after exposure to H2O2.
Whooping Cough
Bordetella pertussis filamentous hemagglutinin gene: molecular cloning of a potential coding sequence.
DNA-based vaccination reduces the risk of lethal anaphylactic hypersensitivity in mice.
Use of the promoter fusion transposon Tn5 lac to identify mutations in Bordetella pertussis vir-regulated genes.
Wolman Disease
[Wolman disease, Fabry disease and beta-galactosidase deficiency]
Xeroderma Pigmentosum
DNA adducts of cis-diamminedichloroplatinum(II) and its trans isomer inhibit RNA polymerase II differentially in vivo.
Enhanced host cell reactivation of a UV-damaged reporter gene in pre-UV-treated cells is delayed in Cockayne syndrome cells.
Increased expression of p53 enhances transcription-coupled repair and global genomic repair of a UVC-damaged reporter gene in human cells.
Yellow Fever
Reduction of yellow fever virus mouse neurovirulence by immunization with a bacterially synthesized non-structural protein (NS1) fragment.