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Synonyms
alpha-glucosidase, maltase, neutral alpha-glucosidase, alpha-d-glucosidase, alglucosidase alfa, intestinal maltase, intestinal alpha-glucosidase, alpha-1,4-glucosidase, recombinant human gaa, alpha-glucosidase ii,
more
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4-nitrophenyl alpha-D-glucopyranoside + H2O
4-nitrophenol + alpha-D-glucose
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-
-
?
4-nitrophenyl alpha-D-glucopyranoside + H2O
4-nitrophenol + alpha-D-glucopyranose
-
-
-
-
?
4-nitrophenyl alpha-D-glucopyranoside + H2O
4-nitrophenol + alpha-D-glucose
4-nitrophenyl alpha-D-glucopyranoside + H2O
4-nitrophenol + D-glucose
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-
-
-
?
dextrin + H2O
?
-
-
-
-
?
glycogen + H2O
alpha-D-glucose
recombinant enzyme
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-
?
isomaltose + H2O
2 alpha-D-glucose
-
-
-
-
?
maltodextrin + H2O
alpha-D-glucose
-
-
-
-
?
maltoheptaose + H2O
maltohexaose + D-glucose
-
-
-
-
?
maltohexaose + H2O
maltopentaose + D-glucose
-
-
-
-
?
maltose + H2O
2 D-glucose
maltose + H2O
alpha-D-glucose + D-glucose
maltotetraose + H2O
alpha-D-glucose
-
-
-
-
?
maltotriose + H2O
maltose + D-glucose
-
-
-
-
?
methyl-alpha-glucoside + H2O
methanol + alpha-D-glucose
-
-
-
-
?
p-nitrophenyl-alpha-D-glucopyranoside + H2O
4-nitrophenol + D-glucose
-
-
-
-
?
starch + H2O
alpha-D-glucose
-
no activity
-
-
?
additional information
?
-
4-nitrophenyl alpha-D-glucopyranoside + H2O
4-nitrophenol + alpha-D-glucose
-
-
-
-
?
4-nitrophenyl alpha-D-glucopyranoside + H2O
4-nitrophenol + alpha-D-glucose
-
-
-
?
maltose + H2O
2 D-glucose
-
-
-
-
?
maltose + H2O
2 D-glucose
-
preferred substrate
-
-
?
maltose + H2O
alpha-D-glucose + D-glucose
-
-
-
-
?
maltose + H2O
alpha-D-glucose + D-glucose
-
-
-
?
maltose + H2O
alpha-D-glucose + D-glucose
-
-
-
-
?
maltose + H2O
alpha-D-glucose + D-glucose
preferred substrate, Asp251 and Trp284 interact with the position 6 OH group of the substrate
-
-
?
additional information
?
-
substrate specificity, overview
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-
?
additional information
?
-
-
substrate specificity, overview
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-
?
additional information
?
-
-
no activity with starch and amylose
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-
?
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expression in Escherichia coli
enzyme expression in Lactococcus lactis strain NZ9000, method optimization, overview
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expression in Escherichia coli
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expression of the thermostable, cytosolic enzyme in Escherichia coli strain BL21(DE3) using a microfiltration membrane bioreactor to improve the control of the concentration of key components in the growth of the cells, overview
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gene malA, DNA and amino acid sequence analysis, phylogenetic tree, overexpression of wild-type and selenomethionine-labeled enzyme in Escherichia coli strain NF1830
gene malA, library preparation, DNA and amino acid sequence determination and analysis, genetic structure and organization, sequences 3' to position -33, including a consensus archaeal TATA box, play an essential role in malA expression, detection of malA homologues, overview, phylogenetic analysis, expression of MalA in Escherichia coli revealing differences from the native enzyme in thermostability and electrophoretic behavior, overview
gene malA, overexpression of wild-type and selenomethionine-labeled enzyme in Escherichia coli
-
gene SsGA, DNA sequence determination and analysis, expression in Escherichia coli BL21(DE3), cytosolic recombinant enzyme
-
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Rolfsmeier, M.; Blum, P.
Purification and characterization of a maltase from the extremely thermophilic crenarchaeote Sulfolobus solfataricus
J. Bacteriol.
177
482-485
1995
Saccharolobus solfataricus
brenda
Martino, A.; Schiraldi, C.; Fusco, S.; Di Lernia, I.; Costabile, T.; Pellicano, T.; Marotta, M.; Generoso, M.; van der Oost, J.; Sensen, C.W.; Charlebois, R.L.; Moracci, M.; Rossi, M.; De Rosa, M.
Properties of the recombinant alpha-glucosidase from Sulfolobus solfataricus in relation to starch processing
J. Mol. Catal. B
11
787-794
2001
Saccharolobus solfataricus, Saccharolobus solfataricus MT-4 / DSM 5833
-
brenda
Chang, S.T.; Parker, K.N.; Bauer, M.W.; Kelly, R.M.
alpha-Glucosidase from Pyrococcus furiosus
Methods Enzymol.
330
260-269
2001
Pyrococcus furiosus, Pyrococcus woesei, Saccharolobus solfataricus, Thermococcus sp., Thermococcus sp. AN1, Saccharolobus solfataricus 98/2
brenda
Ernst, H.A.; Willemoes, M.; Lo Leggio, L.; Leonard, G.; Blum, P.; Larsen, S.
Characterization of different crystal forms of the alpha-glucosidase MalA from Sulfolobus solfataricus
Acta Crystallogr. Sect. F
61
1039-1042
2005
Saccharolobus solfataricus
brenda
Ernst, H.A.; Lo Leggio, L.; Willemoes, M.; Leonard, G.; Blum, P.; Larsen, S.
Structure of the Sulfolobus solfataricus alpha-glucosidase: implications for domain conservation and substrate recognition in GH31
J. Mol. Biol.
358
1106-1124
2006
Saccharolobus solfataricus (P0CD66), Saccharolobus solfataricus
brenda
Giuliano, M.; Schiraldi, C.; Marotta, M.R.; Hugenholtz, J.; De Rosa, M.
Expression of Sulfolobus solfataricus alpha-glucosidase in Lactococcus lactis
Appl. Microbiol. Biotechnol.
64
829-832
2004
Saccharolobus solfataricus
brenda
Schiraldi, C.; Martino, A.; Acone, M.; Di Lernia, I.; Di Lazzaro, A.; Marulli, F.; Generoso, M.; Carteni, M.; De Rosa, M.
Effective production of a thermostable alpha-glucosidase from Sulfolobus solfataricus in Escherichia coli exploiting a microfiltration bioreactor
Biotechnol. Bioeng.
70
670-676
2000
Saccharolobus solfataricus, Saccharolobus solfataricus MT-4 / DSM 5833
brenda
Rolfsmeier, M.; Haseltine, C.; Bini, E.; Clark, A.; Blum, P.
Molecular characterization of the alpha-glucosidase gene (malA) from the hyperthermophilic archaeon Sulfolobus solfataricus
J. Bacteriol.
180
1287-1295
1998
Saccharolobus solfataricus (P0CD66), Saccharolobus solfataricus
brenda
Hakamata, W.; Kurihara, M.; Okuda, H.; Nishio, T.; Oku, T.
Design and screening strategies for alpha-glucosidase inhibitors based on enzymological information
Curr. Top. Med. Chem.
9
3-12
2009
Apis mellifera, Aspergillus niger, Geobacillus stearothermophilus, Beta vulgaris, Saccharomyces cerevisiae, Oryza sativa, Zea mays, Saccharolobus solfataricus (P0CD66)
brenda
Haseltine, C.; Montalvo-Rodriguez, R.; Carl, A.; Bini, E.; Blum, P.
Extragenic pleiotropic mutations that repress glycosyl hydrolase expression in the hyperthermophilic archaeon Sulfolobus solfataricus
Genetics
152
1353-1361
1999
Saccharolobus solfataricus (D0KQM8), Saccharolobus solfataricus, Saccharolobus solfataricus 98/2 (D0KQM8)
brenda
Schiraldi, C.; Martino, A.; Costabile, T.; Generoso, M.; Marotta, M.; De Rosa, M.
Glucose production from maltodextrins employing a thermophilic immobilized cell biocatalyst in a packed-bed reactor
Enzyme Microb. Technol.
34
415-421
2004
Saccharolobus solfataricus, Saccharolobus solfataricus MT4
-
brenda
Haseltine, C.; Montalvo-Rodriguez, R.; Bini, E.; Carl, A.; Blum, P.
Coordinate transcriptional control in the hyperthermophilic archaeon Sulfolobus solfataricus
J. Bacteriol.
181
3920-3927
1999
Saccharolobus solfataricus
brenda