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Synonyms
neuraminidase, sialidase, glycosyl hydrolase, trans-sialidase, hemagglutinin-neuraminidase, major surface antigen, alpha2,6-sialyltransferase, cytosolic sialidase, endosialidase, lysosomal sialidase,
more
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2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
4-methylumbelliferol + alpha-D-N-acetylneuraminic acid
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2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
4-methylumbelliferone + N-acetyl-alpha-D-neuraminic acid
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?
2-(4-nitrophenyl)-alpha-D-N-acetylneuraminic acid + H2O
4-nitrophenol + alpha-D-N-acetylneuraminic acid
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?
2-chloro-5-(4-methoxyspiro(1,2-dioxetane-3,29-(5-chloro)tricyclo[3.3.1.13,7]decan)-4-yl-phenyl-5-acetamido-3,5-dideoxy-alpha-D-glycero-D-galacto-2-nonulopyranoside)onate + H2O
?
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?
4-methylumbelliferyl alpha-D-N-acetylneuraminic acid + H2O
4-methylumbelliferone + N-acetylneuraminic acid
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?
4-nitrophenyl O-(3,5-dideoxy-5-fluoro-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-3)-O-beta-D-galactopyranoside + H2O
?
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?
4-nitrophenyl O-(3,5-dideoxy-5-fluoro-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-6)-O-beta-D-galactopyranoside + H2O
?
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?
4-nitrophenyl O-(3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-3)-O-beta-D-galactopyranoside + H2O
?
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?
4-nitrophenyl O-(3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-6)-O-beta-D-galactopyranoside + H2O
?
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?
4-nitrophenyl O-(3-deoxy-5-O-methyl-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-3)-O-beta-D-galactopyranoside + H2O
?
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?
4-nitrophenyl O-(3-deoxy-5-O-methyl-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-6)-O-beta-D-galactopyranoside + H2O
?
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?
4-nitrophenyl O-(5-azido-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-3)-O-beta-D-galactopyranoside + H2O
?
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?
4-nitrophenyl O-(5-azido-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-6)-O-beta-D-galactopyranoside + H2O
?
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?
4-nitrophenyl O-[5-(2-azidoacetamido)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid]-(2-3)-O-beta-D-galactopyranoside + H2O
?
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?
4-nitrophenyl O-[5-(2-azidoacetamido)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid]-(2-6)-O-beta-D-galactopyranoside + H2O
?
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?
4-nitrophenyl O-[5-(2-fluoroacetamido)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid]-(2-3)-O-beta-D-galactopyranoside + H2O
?
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?
4-nitrophenyl O-[5-(2-fluoroacetamido)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid]-(2-6)-O-beta-D-galactopyranoside + H2O
?
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?
4-nitrophenyl O-[5-(2-methoxyacetamido)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid]-(2-3)-O-beta-D-galactopyranoside + H2O
?
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?
4-nitrophenyl O-[5-(2-methoxyacetamido)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid]-(2-6)-O-beta-D-galactopyranoside + H2O
?
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?
alpha(2-6)-sialyllactose + H2O
sialic acid + lactose
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?
alpha-sialyllactose + H2O
sialic acid + lactose
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?
N-(2,4,7,8,9-penta-O-acetyl-N-acetyl-beta-D-neuraminoyl)phenylalanine methylester + H2O
?
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?
N-(4,7,8,9-tetra-O-acetyl-N-acetyl-2-O-benzyl-alpha-D-neuraminoyl)phenylalanine methylester + H2O
?
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?
Neu5Gcalpha-(2-5)-O-glycolylNeu5Gc + H2O
2 Neu5Gcalpha
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?
Neu5Gcalpha-(2-8)-Neu5Ac + H2O
Neu5Gc + Neu5Ac
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preferred substrate
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?
Neu5Gcalpha-(2-8)-Neu5Gc + H2O
Neu5Gc + Neu5Gc
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additional information
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additional information
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essential enzyme, enzyme containing culture filtrate possesses the ability to agglutinate and virus and shows receptor properties for erythrocytes, bacterial enzymes may serve as a colonization and virulence factor or as an important tool for nutrification
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additional information
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no activity with sialyl-alpha-(2-8)-sialic acid
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?
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2-deoxy-2,3-dehydro-N-acetylneuraminic acid
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inhibition occurs in the micromolar range
5-acetamido-2-(4-N-5-dimethylaminonaphthalene-1-sulfonyl-2-difluoromethylphenyl)3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosonic acid
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irreversible and competitive
asteropine A
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a conotoxin-like peptide from the marine sponge Asteropus simplex, competitive inhibition
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calopocarpin
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noncompetitive inhibition
cristacarpin
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noncompetitive inhibition
demethylmedicarpin
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noncompetitive inhibition
erystagallin A
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noncompetitive inhibition
erysubin D
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competitive inhibitor
erysubin E
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noncompetitive inhibition
erythribyssin D
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i.e. 3-hydroxy-[2',2'-(3'-hydroxy)-dimethylpyrano]-(5',6':10,9)-(6aR,11aR)pterocarpan
erythribyssin L
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i.e. 9-hydroxy-10-prenyl-[2',2'-(3'-hydroxy)-dimethylpyrano]-(5',6':2,3)-(6aR,11aR)pterocarpan
erythribyssin M
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3-hydroxy-[2',2'-(3'-hydroxy)-dimethylpyrano]-(5',6':10,9)-(6aS,11aS)pterocarpan
erythribyssin O
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noncompetitive inhibition
eryvarin D
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noncompetitive inhibition
isoneorautenol
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noncompetitive inhibition
neorautenol
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noncompetitive inhibition
phaseollin
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competitive inhibitor
sophorapterocarpan A
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noncompetitive inhibition
zanamivir
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inhibition occurs in the millimolar range
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0.00755
calopocarpin
Vibrio cholerae serotype O1
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-
0.02203
cristacarpin
Vibrio cholerae serotype O1
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0.02954
demethylmedicarpin
Vibrio cholerae serotype O1
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-
0.02774
erystagallin A
Vibrio cholerae serotype O1
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-
0.02639
erysubin D
Vibrio cholerae serotype O1
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-
0.01948
erysubin E
Vibrio cholerae serotype O1
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-
0.0462
erythribyssin D
Vibrio cholerae serotype O1
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-
0.02714
erythribyssin L
Vibrio cholerae serotype O1
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-
0.07773
erythribyssin M
Vibrio cholerae serotype O1
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-
0.00035
erythribyssin O
Vibrio cholerae serotype O1
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-
0.0033
eryvarin D
Vibrio cholerae serotype O1
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-
0.06475
isoneorautenol
Vibrio cholerae serotype O1
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-
0.05311
neorautenol
Vibrio cholerae serotype O1
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-
0.0314
phaseollin
Vibrio cholerae serotype O1
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-
0.01159
sophorapterocarpan A
Vibrio cholerae serotype O1
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-
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Eschenfelder, V.; Brossmer, R.; Wachter, M.
On the specificity of sialidase: synthesis and properties of N5-acetyl-beta-D-neuraminoylpeptides - AcNeu-Gly-OH, AcNeu-Glu-OH, AcNeu-Phe-OH - and the corresponding alpha-ketosides
Hoppe-Seyler's Z. Physiol. Chem.
364
1411-1417
1983
Vibrio cholerae serotype O1
brenda
Gottschalk, A.
Neuraminidase
The Enzymes, 2nd Ed (Boyer, P. D. , Lardy, H. , Myrbck, K. , eds. )
4
461-473
1960
unidentified influenza virus, Vibrio cholerae serotype O1
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brenda
Inoue, S.; Lin, S.L.; Inoue, Y.; Groves, D.R.; Thomson, R.J.; von Itzstein, M.; Pavlova, N.V.; Li, S.C.; Li, Y.T.
A unique sialidase that cleaves the Neu5Gcalpha2->5-OglycolylNeu5Gc linkage: comparison of its specificity with that of three microbial sialidases toward four sialic acid dimers
Biochem. Biophys. Res. Commun.
280
104-109
2001
Paenarthrobacter ureafaciens, Clostridium perfringens, Crassostrea virginica, Vibrio cholerae serotype O1
brenda
Abrashev, I.; Dulguerova, G.
Neuraminidases (sialidases) from bacterial origin
Exp. Pathol. Parasitol.
4
35-40
2000
Glutamicibacter nicotianae, Arthrobacter sp., Paenarthrobacter ureafaciens, Clostridium chauvoei, Clostridium perfringens, Paeniclostridium sordellii, Corynebacterium diphtheriae, Corynebacterium ulcerans, Pasteurella multocida, Streptococcus sp., Trichomonas vaginalis, Micromonospora viridifaciens, Erysipelothrix rhusiopathiae, Vibrio cholerae serotype O1, Paeniclostridium sordellii G12
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brenda
Hinou, H.; Kurogochi, M.; Shimizu, H.; Nishimura, S.
Characterization of Vibrio cholerae neuraminidase by a novel mechanism-based fluorescent labeling reagent
Biochemistry
44
11669-11675
2005
Vibrio cholerae serotype O1
brenda
Takada, K.; Hamada, T.; Hirota, H.; Nakao, Y.; Matsunaga, S.; van Soest, R.W.; Fusetani, N.
Asteropine A, a sialidase-inhibiting conotoxin-like peptide from the marine sponge Asteropus simplex
Chem. Biol.
13
569-574
2006
Clostridium perfringens, Salmonella enterica subsp. enterica serovar Typhimurium, influenza A virus, Vibrio cholerae serotype O1
brenda
Nguyen, P.H.; Nguyen, T.N.; Kang, K.W.; Ndinteh, D.T.; Mbafor, J.T.; Kim, Y.R.; Oh, W.K.
Prenylated pterocarpans as bacterial neuraminidase inhibitors
Bioorg. Med. Chem.
18
3335-3344
2010
Clostridium perfringens, Vibrio cholerae serotype O1
brenda
Cao, H.; Li, Y.; Lau, K.; Muthana, S.; Yu, H.; Cheng, J.; Chokhawala, H.A.; Sugiarto, G.; Zhang, L.; Chen, X.
Sialidase substrate specificity studies using chemoenzymatically synthesized sialosides containing C5-modified sialic acids
Org. Biomol. Chem.
7
5137-5145
2009
Clostridium perfringens, Streptococcus pneumoniae, Pasteurella multocida, Salmonella enterica subsp. enterica serovar Typhimurium, Vibrio cholerae serotype O1
brenda
Nishikawa, T.; Shimizu, K.; Tanaka, T.; Kuroda, K.; Takayama, T.; Yamamoto, T.; Hanada, N.; Hamada, Y.
Bacterial neuraminidase rescues influenza virus replication from inhibition by a neuraminidase inhibitor
PLoS ONE
7
e45371
2012
Paenarthrobacter ureafaciens, Streptococcus pneumoniae, influenza A virus, Vibrio cholerae serotype O1, Streptococcus pneumoniae IID553
brenda