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2-acetamido-2-deoxy-5-fluoro-beta-D-glucopyranosyl fluoride + H2O
fluoride + N-acetyl-beta-D-glucosaminide
a substrate contains a modest leaving group as well as a poor nucleophile, the catalytic efficiency of the enzyme is synergistically impaired. Testing a wide range of such substrates and obtained co-crystals of BtGH84, to test if under the right conditions, such a substrate might be trapped in the active site unhydrolyzed
-
-
?
3,4,6-triacetyl-O-GlcNAc-Fmoc-Ser-OH + H2O
?
-
-
-
-
?
3,4,6-triacetyl-O-GlcNAc-Fmoc-Thr-OH + H2O
?
-
-
-
-
?
3,4-difluorophenyl 2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranose + 3,4-difluorophenol
-
-
-
-
?
3,4-difluorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranose + 3,4-difluorophenol
-
-
-
-
?
3,4-difluorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranose + 3,4-difluorophenol
-
-
-
-
?
3,4-difluorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranose + 3,4-difluorophenol
-
-
-
-
?
3,4-difluorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranose + 3,4-difluorophenol
-
-
-
-
?
3,4-difluorophenyl 2-deoxy-2-difluoroacetamido-beta-D-glucopyranoside + H2O
3,4-difluorophenol + 2-deoxy-2-difluoroacetamido-beta-D-glucopyranose
a substrate contains a modest leaving group as well as a poor nucleophile, the catalytic efficiency of the enzyme is synergistically impaired. Testing a wide range of such substrates and obtained co-crystals of BtGH84, to test if under the right conditions, such a substrate might be trapped in the active site unhydrolyzed
-
-
?
3,4-dinitrophenyl 2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranose + 3,4-dinitrophenol
-
-
-
-
?
3,4-dinitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranose + 3,4-dinitrophenol
-
-
-
-
?
3,4-dinitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranose + 3,4-dinitrophenol
-
-
-
-
?
3,4-dinitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranose + 3,4-dinitrophenol
-
-
-
-
?
3,4-dinitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranose + 3,4-dinitrophenol
-
-
-
-
?
3,4-dinitrophenyl N-acetyl-beta-D-glucosaminide + H2O
3,4-dinitrophenol + N-acetyl-beta-D-glucosamine
-
-
-
-
?
3-fluoro-4-nitrophenyl 2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranose + 3-fluoro-4-nitrophenol
-
-
-
-
?
3-fluoro-4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranose + 3-fluoro-4-nitrophenol
-
-
-
-
?
3-fluoro-4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranose + 3-fluoro-4-nitrophenol
-
-
-
-
?
3-fluoro-4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranose + 3-fluoro-4-nitrophenol
-
-
-
-
?
3-fluoro-4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranose + 3-fluoro-4-nitrophenol
-
-
-
-
?
3-fluoro-4-nitrophenyl N-acetyl-beta-D-glucosaminide + H2O
3-fluoro-4-nitrophenol + N-acetyl-beta-D-glucosamine
-
-
-
-
?
3-nitrophenyl 2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranose + 3-nitrophenol
-
-
-
-
?
3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranose + 3-nitrophenol
-
-
-
-
?
3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranose + 3-nitrophenol
-
-
-
-
?
3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranose + 3-nitrophenol
-
-
-
-
?
3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranose + 3-nitrophenol
-
-
-
-
?
3-nitrophenyl N-acetyl-beta-D-glucosaminide + H2O
3-nitrophenol + N-acetyl-beta-D-glucosamine
-
-
-
-
?
4-aminophenyl 2-(acetylamino)-2-deoxy-beta-D-glucopyranoside + H2O
?
-
67% relative activity compared to 4-nitrophenyl-beta-D-GlcNac
-
-
?
4-chloro-3-nitrophenyl 2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranose + 4-chloro-3-nitrophenol
-
-
-
-
?
4-chloro-3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranose + 4-chloro-3-nitrophenol
-
-
-
-
?
4-chloro-3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranose + 4-chloro-3-nitrophenol
-
-
-
-
?
4-chloro-3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranose + 4-chloro-3-nitrophenol
-
-
-
-
?
4-chloro-3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranose + 4-chloro-3-nitrophenol
-
-
-
-
?
4-chlorophenyl 2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranose + 4-chlorophenol
-
-
-
-
?
4-chlorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranose + 4-chlorophenol
-
-
-
-
?
4-chlorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranose + 4-chlorophenol
-
-
-
-
?
4-chlorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranose + 4-chlorophenol
-
-
-
-
?
4-chlorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranose + 4-chlorophenol
-
-
-
-
?
4-chlorophenyl N-acetyl-beta-D-glucosaminide + H2O
4-chlorophenol + N-acetyl-beta-D-glucosamine
-
-
-
-
?
4-cyanophenyl 2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranose + 4-cyanophenol
-
-
-
-
?
4-cyanophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranose + 4-cyanophenol
-
-
-
-
?
4-cyanophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranose + 4-cyanophenol
-
-
-
-
?
4-cyanophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranose + 4-cyanophenol
-
-
-
-
?
4-cyanophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranose + 4-cyanophenol
-
-
-
-
?
4-methoxyphenyl 2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranoside + 4-methoxyphenol
-
-
-
-
?
4-methoxyphenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranose + 4-methoxyphenol
-
-
-
-
?
4-methoxyphenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranose + 4-methoxyphenol
-
-
-
-
?
4-methoxyphenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranose + 4-methoxyphenol
-
-
-
-
?
4-methoxyphenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranose + 4-methoxyphenol
-
-
-
-
?
4-methylumbelliferyl 2-(acetylamino)-2-deoxy-beta-D-glucopyranoside + H2O
?
-
33% relative activity compared to 4-nitrophenyl-beta-D-GlcNac
-
-
?
4-methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside + H2O
4-methylumbelliferone + 2-acetamido-2-deoxy-beta-D-glucopyranose
substrate with a 4-methylumbelliferone leaving group. A substrate contains a modest leaving group as well as a poor nucleophile, the catalytic efficiency of the enzyme is synergistically impaired. Testing a wide range of such substrates and obtained co-crystals of BtGH84, to test if under the right conditions, such a substrate might be trapped in the active site unhydrolyzed
-
-
?
4-methylumbelliferyl 2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranose + 4-methylumbelliferone
-
-
-
-
?
4-methylumbelliferyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranose + 4-methylumbelliferone
-
-
-
-
?
4-methylumbelliferyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranose + 4-methylumbelliferone
-
-
-
-
?
4-methylumbelliferyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranose + 4-methylumbelliferone
-
-
-
-
?
4-methylumbelliferyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranose + 4-methylumbelliferone
-
-
-
-
?
4-methylumbelliferyl beta-D-N-acetylglucosaminide + H2O
4-methylumbelliferone + beta-D-N-acetylglucosamine
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-acetyl-beta-D-glucosamine
4-methylumbelliferyl N-difluoroacetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-difluoroacetyl-beta-D-glucosamine
4-methylumbelliferyl N-fluoroacetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-fluoroacetyl-beta-D-glucosamine
4-methylumbelliferyl N-trifluoroacetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-trifluoroacetyl-beta-D-glucosamine
4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside + H2O
4-methylumbelliferol + N-acetyl-beta-D-glucosamine
-
-
-
-
?
4-methylumbelliferyl-N-acetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-acetyl-beta-D-glucosamine
fluorogenic substrate, 4MU-NAG
-
-
?
4-nitrophenyl 2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranose + 4-nitrophenol
-
-
-
-
?
4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranose + 4-nitrophenol
-
-
-
-
?
4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranose + 4-nitrophenol
-
-
-
-
?
4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranose + 4-nitrophenol
-
-
-
-
?
4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranose + 4-nitrophenol
-
-
-
-
?
4-nitrophenyl beta-D-GlcNAc + H2O
4-nitrophenol + N-acetyl-D-glucosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-beta-D-glucosaminide + H2O
4-nitrophenol + N-acetyl-beta-D-glucosamine
4-nitrophenyl N-acetyl-beta-D-thioglucosaminide + H2O
4-nitrophenol + N-acetyl-beta-D-thioglucosamine
Ala-Ser(O-GlcNAc)-Tyr + H2O
Ala-Ser-Tyr + N-acetyl-beta-D-glucosamine
-
is synthesized using standard N-(9-fluorenyl)methoxycarbonyl (FMOC) chemistry
-
-
?
fluorescein di(N-acetyl-beta-D-glucosaminide) + H2O
fluorescein mono(N-acetyl-beta-D-glucosaminide) + N-acetyl-D-glucosamine
GlcNAc beta(1-4)GlcNAc + H2O
N-acetyl-D-glucosamine + N-acetyl-D-glucosamine
-
4% relative activity. Enzyme can cleave terminal Glc-NAc from disaccharides to a limited extent as long as GlcNAc is linked to the other saccharides beta-linkage at the C-1 position
-
-
?
GlcNAc beta(1-6)Gal + H2O
N-acetyl-D-glucosamine + beta-D-galactose
-
29% relative activity. Enzyme can cleave terminal Glc-NAc from disaccharides to a limited extent as long as GlcNAc is linked to the other saccharides beta-linkage at the C-1 position
-
-
?
GlcNAcbeta(1-6)Man-beta-1-OMe + H2O
N-acetyl-D-glucosamine + methyl beta-D-mannoside
-
33% relative activity. Enzyme can cleave terminal Glc-NAc from disaccharides to a limited extent as long as GlcNAc is linked to the other saccharides beta-linkage at the C-1 position
-
-
?
methyl 2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranose + methanol
-
-
-
-
?
methyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranose + methanol
-
-
-
-
?
methyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranose + methanol
-
-
-
-
?
methyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranose + methanol
-
-
-
-
?
methyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranose + methanol
-
-
-
-
?
N-acetyl-4-aminophenyl N-acetyl-beta-D-glucosaminide + H2O
N-acetyl-4-aminophenol + N-acetyl-beta-D-glucosamine
-
-
-
-
?
P-(GlcNAc)STST + H2O
PSTST + N-acetyl-D-glucosamine
-
-
-
-
?
phenyl 2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-N,O3,O4,O6-tetraacetyl-beta-D-glucopyranose + phenol
-
-
-
-
?
phenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranose + phenol
-
-
-
-
?
phenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranose + phenol
-
-
-
-
?
phenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranose + phenol
-
-
-
-
?
phenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside + H2O
2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranose + phenol
-
-
-
-
?
phenyl N-acetyl-beta-D-glucosaminide + H2O
phenol + N-acetyl-beta-D-glucosamine
-
-
-
-
?
VPST(GlcNAc)MSAN + H2O
VPSTMSAN + N-acetyl-beta-D-glucosamine
-
-
-
-
?
YSD-(GlcNAc)SPSTST + H2O
YSDSPSTST + N-acetyl-D-glucosamine
-
-
-
-
?
[alpha-crystallin B chain]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O
[alpha-crystallin B chain]-L-serine + N-acetyl-D-glucosamine
the sequence of alpha-crystallin B chain is FPTSTSLSPFYLR
-
-
?
[dHCF peptide]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H2O
[dHCF peptide]-L-threonine + N-acetyl-D-glucosamine
-
i.e. VPSgTMSAN
-
-
?
[ELK1 protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H2O
[ELK1 protein]-L-threonine + N-acetyl-D-glucosamine
the sequence of ELK1 protein is FWSTLSPI
-
-
?
[host cell factor protein]-3-O-(N-acetyl-beta-D-hexosaminyl)-L-threonine + H2O
[host cell factor protein]-L-threonine + N-acetyl-D-hexosamine
-
the sequence of host cell factor protein is IVPSVtASHSLR, t indicates the HexNAc-modified residue
-
-
?
[lamin B1]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H2O
[lamin B1]-L-threonine + N-acetyl-D-glucosamine
the sequence of lamin B1 protein is KLSPSPSSRVTVS
-
-
?
[nucleoporin 153]-3-O-(N-acetyl-beta-D-hexosaminyl)-L-serine + H2O
[nucleoporin 153]-L-serine + N-acetyl-D-hexosamine
-
the seque4nce of nucleoporin 153 is FDLIIKPTVPVVsKPSTTDPIQSSK. s indicates the HexNAc-modified residue
-
-
?
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O
[protein]-L-serine + N-acetyl-D-glucosamine
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H2O
[protein]-L-threonine + N-acetyl-D-glucosamine
[TAB1 protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O
[TAB1 protein]-L-serine + N-acetyl-D-glucosamine
additional information
?
-
4-methylumbelliferyl beta-D-N-acetylglucosaminide + H2O
4-methylumbelliferone + beta-D-N-acetylglucosamine
-
-
-
?
4-methylumbelliferyl beta-D-N-acetylglucosaminide + H2O
4-methylumbelliferone + beta-D-N-acetylglucosamine
-
-
-
?
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-acetyl-beta-D-glucosamine
-
-
-
?
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-acetyl-beta-D-glucosamine
-
-
-
?
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-acetyl-beta-D-glucosamine
-
-
-
-
?
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-acetyl-beta-D-glucosamine
-
-
-
-
?
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-acetyl-beta-D-glucosamine
-
-
-
?
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-acetyl-beta-D-glucosamine
-
fluorogenic substrate, 4MU-NAG
-
-
?
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-acetyl-beta-D-glucosamine
-
MUGlcNAc
-
-
?
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-acetyl-beta-D-glucosamine
-
-
-
?
4-methylumbelliferyl N-difluoroacetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-difluoroacetyl-beta-D-glucosamine
-
-
-
?
4-methylumbelliferyl N-difluoroacetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-difluoroacetyl-beta-D-glucosamine
-
-
-
-
?
4-methylumbelliferyl N-fluoroacetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-fluoroacetyl-beta-D-glucosamine
-
-
-
?
4-methylumbelliferyl N-fluoroacetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-fluoroacetyl-beta-D-glucosamine
-
-
-
-
?
4-methylumbelliferyl N-trifluoroacetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-trifluoroacetyl-beta-D-glucosamine
-
-
-
?
4-methylumbelliferyl N-trifluoroacetyl-beta-D-glucosaminide + H2O
4-methylumbelliferone + N-trifluoroacetyl-beta-D-glucosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-beta-D-glucosaminide + H2O
4-nitrophenol + N-acetyl-beta-D-glucosamine
-
-
-
?
4-nitrophenyl N-acetyl-beta-D-glucosaminide + H2O
4-nitrophenol + N-acetyl-beta-D-glucosamine
-
-
-
?
4-nitrophenyl N-acetyl-beta-D-glucosaminide + H2O
4-nitrophenol + N-acetyl-beta-D-glucosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-beta-D-glucosaminide + H2O
4-nitrophenol + N-acetyl-beta-D-glucosamine
-
-
-
?
4-nitrophenyl N-acetyl-beta-D-glucosaminide + H2O
4-nitrophenol + N-acetyl-beta-D-glucosamine
-
-
-
?
4-nitrophenyl N-acetyl-beta-D-glucosaminide + H2O
4-nitrophenol + N-acetyl-beta-D-glucosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-beta-D-thioglucosaminide + H2O
4-nitrophenol + N-acetyl-beta-D-thioglucosamine
-
-
-
?
4-nitrophenyl N-acetyl-beta-D-thioglucosaminide + H2O
4-nitrophenol + N-acetyl-beta-D-thioglucosamine
-
enzyme cleaves p-nitrophenyl-S-GlcNAc with comparable efficiency as p-nitrophenyl-O-GlcNAc
-
-
?
fluorescein di(N-acetyl-beta-D-glucosaminide) + H2O
fluorescein mono(N-acetyl-beta-D-glucosaminide) + N-acetyl-D-glucosamine
-
-
-
-
?
fluorescein di(N-acetyl-beta-D-glucosaminide) + H2O
fluorescein mono(N-acetyl-beta-D-glucosaminide) + N-acetyl-D-glucosamine
-
FDGlcNAc, fluorogenic substrate
-
-
?
fluorescein di(N-acetyl-beta-D-glucosaminide) + H2O
fluorescein mono(N-acetyl-beta-D-glucosaminide) + N-acetyl-D-glucosamine
-
-
-
?
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O
[protein]-L-serine + N-acetyl-D-glucosamine
-
-
-
-
?
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O
[protein]-L-serine + N-acetyl-D-glucosamine
-
-
-
?
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O
[protein]-L-serine + N-acetyl-D-glucosamine
-
-
-
-
?
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O
[protein]-L-serine + N-acetyl-D-glucosamine
-
-
-
?
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O
[protein]-L-serine + N-acetyl-D-glucosamine
-
-
-
-
?
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O
[protein]-L-serine + N-acetyl-D-glucosamine
-
-
-
?
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H2O
[protein]-L-threonine + N-acetyl-D-glucosamine
-
-
-
-
?
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H2O
[protein]-L-threonine + N-acetyl-D-glucosamine
-
-
-
?
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H2O
[protein]-L-threonine + N-acetyl-D-glucosamine
-
-
-
-
?
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H2O
[protein]-L-threonine + N-acetyl-D-glucosamine
-
-
-
?
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H2O
[protein]-L-threonine + N-acetyl-D-glucosamine
-
-
-
-
?
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H2O
[protein]-L-threonine + N-acetyl-D-glucosamine
-
-
-
?
[TAB1 protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O
[TAB1 protein]-L-serine + N-acetyl-D-glucosamine
-
-
-
-
?
[TAB1 protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O
[TAB1 protein]-L-serine + N-acetyl-D-glucosamine
-
-
-
-
?
[TAB1 protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O
[TAB1 protein]-L-serine + N-acetyl-D-glucosamine
the sequence of TAB1 protein is VPYSSAQS
-
-
?
additional information
?
-
enzyme cleaves 4-nitrophenyl N-acetyl-beta-D-glucosaminide from modified proteins and also cleaves 4-nitrophenyl N-acetyl-beta-D-thioglucosaminide
-
-
?
additional information
?
-
when a substrate contains a modest leaving group as well as a poor nucleophile, the catalytic efficiency of the enzyme is synergistically impaired
-
-
?
additional information
?
-
enzyme that removes O-GlcNAc from O-GlcNAcylated proteins
-
-
?
additional information
?
-
has O-GlcNAcase activity against O-GlcNAcylated human proteins, suggesting that the enzyme is a suitable model for further studies into the function of human O-GlcNAcase
-
-
?
additional information
?
-
-
the enzyme can hydrolyze all biantennary glycoforms from human and ovine immunglobuline G
-
-
?
additional information
?
-
-
the enzyme cannot hydrolyze bisecting N-acetyl-beta-D-glucosaminide and shows no activity on bovine or caprine immunoglobuline G and 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide
-
-
?
additional information
?
-
-
the enzyme can hydrolyze all biantennary glycoforms from human and ovine immunglobuline G
-
-
?
additional information
?
-
-
the enzyme cannot hydrolyze bisecting N-acetyl-beta-D-glucosaminide and shows no activity on bovine or caprine immunoglobuline G and 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide
-
-
?
additional information
?
-
-
catalyzes the cleavage of beta-O-linked N-acetyl-beta-D-glucosaminide from modified proteins and is a member of the family 84 glycoside hydrolases
-
-
?
additional information
?
-
-
catalyzing the hydrolytic cleavage of beta-O-linked 2-acetamido-2-deoxy-D-glycopyranose (O-GlcNAc) from serine and threonine residues of posttranslationally modified proteins
-
-
?
additional information
?
-
-
enzyme is responsible for removal of the O-GlcNAc post-translational modification, is being increasingly used to aid in discerning the roles played by this form of intracellular glycosylation
-
-
?
additional information
?
-
-
enzyme removes N-acetyl-beta-D-glucosaminide from proteins
-
-
?
additional information
?
-
-
enzyme that removes N-acetyl-beta-D-glucosamine from O-GlcNAcylated proteins
-
-
?
additional information
?
-
-
O-GlcNAcase uses a catalytic mechanism involving substrate-assisted catalysis. In this mechanism, the leaving group is expelled from the anomeric center by nucleophilic attack of the 2-acetamido group of the substrate to form an oxazoline intermediate
-
-
?
additional information
?
-
-
fluorescein di-N-acetyl-beta-D-galactosaminide (FDGalNAc) is not cleaved by these enzymes, the O-GlcNAcase has substrate specificity toward O-GlcNAc but not O-GalNAc
-
-
?
additional information
?
-
-
removes O-N-acetyl-glucosamine residues from O-GlcNAcylated proteins
-
-
?
additional information
?
-
-
strong selectivity for O-GlcNAc-synthetic glycopeptides. Enzyme does not cleave 4-nitrophenylGalNAc and is highly selective for O-GlcNAc bearing glycopeptides. O-GlcNAcase is involved in the regulated removal of O-GlcNAc from O-GlcNAc-bearing glycoproteins in the nucleoplasmic and cytoplasmic compartments of cells
-
-
?
additional information
?
-
-
shows no activity against other monosaccharides either in alpha or beta linkage to 4-nitrophenyl, such as, 4-nitrophenyl-alpha-D-GlcNAc, 4-nitrophenyl-alpha-D-glucose, 4-nitrophenyl-beta-D-glucose, 4-nitrophenyl-alpha-D-GalNAc, 4-nitrophenyl-beta-D-GalNAc, 4-nitrophenyl-alpha-D-galactose, 4-nitrophenyl-beta-D-galactose, 4-nitrophenyl-alpha-D-mannose, 4-nitrophenyl-alpha-L-fructose
-
-
?
additional information
?
-
-
substitution of GlcNAc at other positions prevents cleavage, for example, Gal(1-3)GlcNAc-p-nitrophenol, Gal(1-4)GlcNAc, Gal(1-3)GlcNAc, and UDP-GlcNAc, the enzyme specifically cleave GlcNAc at C-1 position in beta-linkage to other groups
-
-
?
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(3aS,5R,6S,7R,7aR)-5-(hydroxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
-
NAG-thiazoline, inhibits also other functionally related enzymes
(3aS,5R,6S,7R,7aR)-5-(hydroxymethyl)-2-propyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
-
NButGT, selective O-GlcNAcase inhibitor
(6S,7R,8R)-8-acetamido-6,7-dihydroxy-5-(hydroxymethyl)-N-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxamide
-
PUGNAc-imidazole hybrid
1,2-dideoxy-2'-butyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
-
1,2-dideoxy-2'-ethyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
-
1,2-dideoxy-2'-isobutyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
-
1,2-dideoxy-2'-isopropyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
-
1,2-dideoxy-2'-methyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
1,2-dideoxy-2'-pentyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
-
1,2-dideoxy-2'-propyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
2-((6S,7R,8R)-8-acetamido-6,7-dihydroxy-5-(hydroxymethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)acetate
-
NAGstatin
2-(acetylamino)-2-deoxy-1-S-hexanoyl-1-thio-beta-D-glucopyranose
-
inhibits activity at 10 mM, 47.5% relative activity compared with activity without any addition of effector
2-acetamido-2-deoxy-D-gluconhydroxime-1,5-lactone
-
inhibits activity at 0.1 mM, 6.7% relative activity compared with activity without any addition of effector
2-acetamindo-1-amino-1,2-dideoxy-beta-D-glucopyranose
-
inhibits activity at 10 mM, 3.2% relative activity compared with activity without any addition of effector
2-acetamindo-1-azido-1,2-dideoxy-beta-D-glucopyranose
-
inhibits activity at 10 mM, 19.3% relative activity compared with activity without any addition of effector
2-acetamindo-1-bromo-1,2-dideoxy-beta-D-glucopyranose
-
inhibits activity at 10 mM, 34.8% relative activity compared with activity without any addition of effector
2-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione
22.2% inhibition at 0.1 mM
2-[[1-[(2-acetamido-beta-D-glucopyranosylthiomethyl)-1H-1,2,3-triazol-4-yl]methyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
18.5% inhibition at 0.1 mM
2-[[1-[2-[(2-acetamido-beta-D-glucopyranosyl)thio]ethyl]-1H-1,2,3-triazol-4-yl]methyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
27.8% inhibition at 0.1 mM
2-[[1-[3-[(2-acetamido-beta-D-glucopyranosyl)thio]propyl]-1H-1,2,3-triazol-4-yl]methyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
22.7% inhibition at 0.1 mM
2-[[1-[4-[(2-acetamido-beta-D-glucopyranosyl)thio]butyl]-1H-1,2,3-triazol-4-yl]methyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
25.1% inhibition at 0.1 mM
2-[[1-[5-[(2-acetamido-beta-D-glucopyranosyl)thio]pentyl]-1H-1,2,3-triazol-4-yl]methyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
26% inhibition at 0.1 mM
2-[[1-[6-[(2-acetamido-beta-D-glucopyranosyl)thio]hexyl]-1H-1,2,3-triazol-4-yl]methyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
25.7% inhibition at 0.1 mM
5-(trifluoromethyl)-2,3-dihydro-1H-1,4-diazepine
Ala-Cys(S-GlcNAc)-Ala
pseudosubstrate
alpha-D-mannose
-
inhibits activity at 10 mM, 62.6% relative activity compared with activity without any addition of effector
amen ändern: (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
-
thiamet-G
castanospermine
-
inhibits activity at 10 mM, 32.7% relative activity compared with activity without any addition of effector
Cd2+
-
inhibits activity at 1 mM, 7.7% relative activity compared with activity without any addition of effector
Cu2+
-
inhibits activity at 1 mM, 1% relative activity compared with activity without any addition of effector
D-glucosamine
-
inhibits activity at 10 mM, 60.7% relative activity compared with activity without any addition of effector
deoxynojirimycin
-
slight inhibition
GalNAc
-
an inhibitor of other hexosaminidases
GlcNAcstatin A
-
GlcNAcstatin A carries a carboxymethyl group, GlcNAcstatins are the most potent human O-GlcNAcase inhibitors, inhibiting the enzyme in the sub-nanomolar to nanomolar range
GlcNAcstatin D
-
GlcNAcstatin D carries a phenylethyl moiety. GlcNAcstatins are the most potent human O-GlcNAcase inhibitors, inhibiting the enzyme in the sub-nanomolar to nanomolar range
GlcNAcstatin E
-
GlcNAcstatin E carries a phenylethyl moiety. GlcNAcstatins are the most potent human O-GlcNAcase inhibitors, inhibiting the enzyme in the sub-nanomolar to nanomolar range
Hg2+
-
inhibits activity at 1 mM, 6% relative activity compared with activity without any addition of effector
HPDP-biotin
treatment with a sulfhydrylspecific biotinylation reagent, HPDP-biotin, to biotinylate any accessible free cysteine residue in the native enzyme. Treatment is able to inhibit enzymatic activity, suggesting that the cysteine residue playing a role in catalysis is modified
LOGNAc
i.e. 2-acetamido-2-deoxy-D-gluconhydroximo-1,5-lactone
methyl alpha-D-mannose
-
inhibits activity at 10 mM, 11.3% relative activity compared with activity without any addition of effector. Other sugars and sugar analogs do not inhibit with exception of methyl-alpha-D-mannose
N-((1R,2R,5S,6R)-2-amino-5,6-dihydroxycyclohex-3-enyl)acetamide
-
1-acetamido-epi-valienamine
N-((3R,4R,5R,6S)-3,5,6-trihydroxy-7-(hydroxymethyl)azepan-4-yl)acetamide
-
acetamido-azepane
N-((3S,4R,5R,Z)-4,5-dihydroxy-6-(hydroxymethyl)-2-(phenylcarbamoyloxyimino)tetrahydro-2H-pyran-3-yl)butyramide
-
butyl-PUGNAc
N-((6S,7R,8R)-6,7-dihydroxy-5-(hydroxymethyl)-2-phenethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-yl)isobutyramide
-
GlcNAcstatin
N-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-2-[(2-acetamido-beta-D-glucopyranosyl)thio]acetamide
31.1% inhibition at 0.1 mM
N-acetyl-D-glucosamine
-
inhibits activity at 10 mM, 40% relative activity compared with activity without any addition of effector
N-acetylglucosamino-1,5-lactone oxime
-
LOGNAc
N-methyl-deoxynojirimycin
-
inhibits activity at 10 mM, 73.5% relative activity compared with activity without any addition of effector
N-[(2Z,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[[(phenylcarbamoyl)oxy]imino]tetrahydro-2H-pyran-3-yl]acetamide
-
PUGNAc, inhibits also other functionally related enzymes
N-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-2-[(2-acetamido-beta-D-glucopyranosyl) thio]acetamide
38.6% inhibition at 0.1 mM
N-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-3-[(2-acetamido-beta-D-glucopyranosyl)thio]propanamide
66.9% inhibition at 0.1 mM
N-[3-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propyl]-2-[(2-acetamido-beta-D-glucopyranosyl)thio]acetamide
97.6% inhibition at 0.1 mM
N-[3-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propyl]-3-[(2-acetamido-beta-D-glucopyranosyl)thio]propanamide
59.4% inhibition at 0.1 mM
N-[4-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)butyl]-2-[(2-acetamido-beta-D-glucopyranosyl)thio]acetamide
50% inhibition at 0.1 mM
N-[4-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)butyl]-3-[(2-acetamido-beta-D-glucopyranosyl)thio]propanamide
34.3% inhibition at 0.1 mM
NaCl
-
high salt, 1.0 M NaCl, inhibits enzyme activity by 50% compared with activity without any addition of effector
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenyl carbamate
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate
O-(2-deoxy-2-butamido-D-glucopyranosylidene)amino N-phenylcarbamate
-
inhibitor of both human O-GlcNAcase and human beta-hexosaminidase
O-(2-deoxy-2-hexamido-D-glucopyranosylidene)amino N-phenylcarbamate
-
inhibitor of both human O-GlcNAcase and human beta-hexosaminidase
O-(2-deoxy-2-isobutamido-D-glucopyranosylidene)amino N-phenylcarbamate
-
inhibitor of both human O-GlcNAcase and human beta-hexosaminidase
O-(2-deoxy-2-isovaleramido-D-glucopyranosylidene)amino N-phenylcarbamate
-
inhibitor of both human O-GlcNAcase and human beta-hexosaminidase
O-(2-deoxy-2-propamido-D-glucopyranosylidene)amino N-phenylcarbamate
-
inhibitor of both human O-GlcNAcase and human beta-hexosaminidase
O-(2-deoxy-2-valeramido-D-glucopyranosylidene)amino N-phenylcarbamate
-
inhibitor of both human O-GlcNAcase and human beta-hexosaminidase
p-aminophenyl-S-GlcNAc
-
inhibits activity at 10 mM, 76.3% relative activity compared with activity without any addition of effector
Sn2+
-
inhibits activity at 1 mM, 57.6% relative activity compared with activity without any addition of effector
Tris
-
high salt, 75 mM, inhibits enzyme activity by 50% compared with activity without any addition of effector
UDP-GlcNAc
-
inhibits activity at 10 mM, 78.1% relative activity compared with activity without any addition of effector
Zn2+
-
inhibits activity at 1 mM, 7.3% relative activity compared with activity without any addition of effector
1,2-dideoxy-2'-methyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
NAG-thiazoline
1,2-dideoxy-2'-methyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
an inhibitor that mimics the oxazoline intermediate proposed in the catalytic mechanism of family 20 glycoside hydrolases, is shown to act as a potent competitive inhibitor. NAG-thiazoline is therefore a potent inhibitor of O-GlcNAcase, binding about 21000fold more tightly than the parent saccharide, N-acetyl-beta-D-glucosaminide
1,2-dideoxy-2'-propyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
NButGT
1,2-dideoxy-2'-propyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
-
5-(trifluoromethyl)-2,3-dihydro-1H-1,4-diazepine
-
5-(trifluoromethyl)-2,3-dihydro-1H-1,4-diazepine
-
GlcNAcstatin B
-
GlcNAcstatin B
-
GlcNAcstatin B carries a phenylethyl moiety. GlcNAcstatins are the most potent human O-GlcNAcase inhibitors, inhibiting the enzyme in the sub-nanomolar to nanomolar range
GlcNAcstatin BF
-
GlcNAcstatin C
GlcNAcstatin C carriesa phenylethyl moiety. GlcNAcstatins are the most potent human OGA inhibitors, inhibiting the enzyme in the sub-nanomolar to nanomolar range
GlcNAcstatin C
-
GlcNAcstatin C carriesa phenylethyl moiety. GlcNAcstatins are the most potent human O-GlcNAcase inhibitors, inhibiting the enzyme in the sub-nanomolar to nanomolar range
GlcNAcstatin G
-
N-ethylmaleimide
treatment is able to inhibit enzymatic activity, suggesting that the cysteine residue playing a role in catalysis is modified
N-ethylmaleimide
-
inhibits activity at 10 mM, 15.3% relative activity compared with activity without any addition of effector
NAG-thiazoline
-
-
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate
-
PUGNAc
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate
-
inhibitor of both human O-GlcNAcase and human beta-hexosaminidase
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenyl carbamate
-
PUGNAc
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenyl carbamate
-
PUGNAc
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate
PUGNAc
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate
PUGNAc, transition state mimic
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate
-
PUGNAc
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate
-
PUGNAc
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate
-
inhibits activity at 0.1 mM, 4.1% relative activity compared with activity without any addition of effector
PUGNAc
i.e. O-(2-acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate, 98.9% inhibition at 0.1 mM
PUGNAc
i.e. O-(2-acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate
streptozotocin
binds in the enzyme active site in its intact form, without the formation of a covalent adduct, weak inhibitor
streptozotocin
STZ, diabetogenic compound, acts as a suicide inhibitor
streptozotocin
-
STZ, significantly dose-dependently inhibited recombinant O-GlcNAcase
streptozotocin
-
poor inhibitor
thiamet G
-
additional information
-
methylnitrosourea (MNU), the nitric oxide-containing portion of streptozotocin: no significant inhibition observed
-
additional information
-
streptozotocin does not appear to act as an irreversible inhibitor
-
additional information
-
GlcN-induced whole-body insulin resistance is related to tissue O-GlcNAcase activity and mRNA expression. O-GlcNAcase activity is posttranslationally inhibited during GlcN-induced insulin resistance
-
additional information
-
addition of 50 mM GalNAc does not inhibit the neutral hexosaminidase activity; GlcNAc analogs with no or small effect on the enzyme activity: N-acetylgalactosamine, 4-aminophenyl 1-thio-beta-D-galactopyranoside, (2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-L-asparagine, 2-(acetylamino)-2-deoxy-N-hexanoyl-beta-D-glucopyranosylamine, 2-(acetylamino)-2-deoxy-1-O-phosphono-beta-D-glucopyranose, bromoconduritol, iodoacetic acid, N-acetylneuraminic acid
-
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6.84
3,4-difluorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-beta-D-glucopyranoside
-
-
0.098
3,4-difluorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside
-
-
0.68
3,4-difluorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside
-
-
2.07
3,4-difluorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside
-
-
0.15
3,4-difluorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside
-
-
19.89
3,4-dinitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-beta-D-glucopyranoside
-
-
8.59
3,4-dinitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside
-
-
11.93
3,4-dinitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside
-
-
18.24
3,4-dinitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside
-
-
0.49
3,4-dinitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside
-
-
12.15
3-fluoro-4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-beta-D-glucopyranoside
-
-
1.11
3-fluoro-4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside
-
-
1.67
3-fluoro-4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside
-
-
7.67
3-fluoro-4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside
-
-
0.49
3-fluoro-4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside
-
-
8.49
3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-beta-D-glucopyranoside
-
-
0.154
3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside
-
-
1.96
3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside
-
-
2.71
3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside
-
-
1.16
3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside
-
-
10.36
4-chloro-3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-beta-D-glucopyranoside
-
-
1.47
4-chloro-3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside
-
-
4.81
4-chloro-3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside
-
-
0.41
4-chloro-3-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside
-
-
6.69
4-chlorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-beta-D-glucopyranoside
-
-
0.086
4-chlorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside
-
-
0.49
4-chlorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside
-
-
1.07
4-chlorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside
-
-
0.107
4-chlorophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside
-
-
10.27
4-cyanophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-beta-D-glucopyranoside
-
-
2.17
4-cyanophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside
-
-
4.51
4-cyanophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside
-
-
0.85
4-cyanophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside
-
-
5.04
4-methoxyphenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-beta-D-glucopyranoside
-
-
0.11
4-methoxyphenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside
-
-
0.73
4-methoxyphenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside
-
-
10.61
4-methylumbelliferyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-beta-D-glucopyranoside
-
-
0.241
4-methylumbelliferyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside
-
-
1.14
4-methylumbelliferyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside
-
-
5.41
4-methylumbelliferyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside
-
-
0.23
4-methylumbelliferyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside
-
-
0.0683 - 3620
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide
12.78
4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-beta-D-glucopyranoside
-
-
0.197
4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside
-
-
0.5
4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside
-
-
2.95
4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside
-
-
0.13
4-nitrophenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-trifluoroacetyl-beta-D-glucopyranoside
-
-
0.03 - 112
4-nitrophenyl N-acetyl-beta-D-glucosaminide
1 - 15.3
fluorescein di(N-acetyl-beta-D-glucosaminide)
0.44
methyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-beta-D-glucopyranoside
-
-
0.088
methyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside
-
-
5.82
phenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-beta-D-glucopyranoside
-
-
0.066
phenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-butanoyl-beta-D-glucopyranoside
-
-
0.15
phenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-difluoroacetyl-beta-D-glucopyranoside
-
-
0.94
phenyl 2-deoxy-2-amino-O3,O4,O6-triacetyl-N-fluoroacetyl-beta-D-glucopyranoside
-
-
0.0683
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide
Y335F mutant
0.192
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide
N396A mutant
0.293
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide
D401A mutant
0.325
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide
D298N mutant
6.6
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide
D297N mutant
142.9
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide
W490A mutant
3548
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide
N390A mutant
3620
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide
wild-type
0.03
4-nitrophenyl N-acetyl-beta-D-glucosaminide
truncated enzyme OGA14-341, pH and temperature not specified in the publication
0.04
4-nitrophenyl N-acetyl-beta-D-glucosaminide
truncated enzyme OGA14-400, pH and temperature not specified in the publication
0.12
4-nitrophenyl N-acetyl-beta-D-glucosaminide
truncated enzyme OGA1-662, pH and temperature not specified in the publication
2.9
4-nitrophenyl N-acetyl-beta-D-glucosaminide
truncated enzyme OGA14-400/554-705, pH and temperature not specified in the publication
3.09
4-nitrophenyl N-acetyl-beta-D-glucosaminide
-
-
4.6
4-nitrophenyl N-acetyl-beta-D-glucosaminide
D175A mutant
8.8
4-nitrophenyl N-acetyl-beta-D-glucosaminide
D177N mutant
11
4-nitrophenyl N-acetyl-beta-D-glucosaminide
full-length enzyme, pH and temperature not specified in the publication
19.2
4-nitrophenyl N-acetyl-beta-D-glucosaminide
D174N mutant
37
4-nitrophenyl N-acetyl-beta-D-glucosaminide
truncated enzyme OGA57-400/544-705, pH and temperature not specified in the publication
47.2
4-nitrophenyl N-acetyl-beta-D-glucosaminide
C166S mutant
112
4-nitrophenyl N-acetyl-beta-D-glucosaminide
wild-type
1
fluorescein di(N-acetyl-beta-D-glucosaminide)
-
splice variant (v-O-GlcNAcase)
15.3
fluorescein di(N-acetyl-beta-D-glucosaminide)
-
-
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0.0006 - 0.0015
(3aS,5R,6S,7R,7aR)-5-(hydroxymethyl)-2-propyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
0.0038
(6S,7R,8R)-8-acetamido-6,7-dihydroxy-5-(hydroxymethyl)-N-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxamide
-
-
0.0015
1,2-dideoxy-2'-butyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
-
0.00012
1,2-dideoxy-2'-ethyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
-
0.0057
1,2-dideoxy-2'-isobutyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
-
0.0016
1,2-dideoxy-2'-isopropyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
-
0.00007 - 0.00018
1,2-dideoxy-2'-methyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
0.057
1,2-dideoxy-2'-pentyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
-
0.00023 - 0.0006
1,2-dideoxy-2'-propyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
0.00042
2-((6S,7R,8R)-8-acetamido-6,7-dihydroxy-5-(hydroxymethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)acetate
-
-
0.00168
2-acetamido-2-deoxy-D-gluconhydroxime-1,5-lactone
-
-
0.151
2-acetamindo-1-amino-1,2-dideoxy-beta-D-glucopyranose
-
-
1.14
2-acetamindo-1-azido-1,2-dideoxy-beta-D-glucopyranose
-
-
0.146
5-(trifluoromethyl)-2,3-dihydro-1H-1,4-diazepine
pH and temperature not specified in the publication
0.000021
amen ändern: (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
-
-
0.0000043
GlcNAcstatin A
-
-
0.00000042 - 0.000066
GlcNAcstatin B
0.0000044 - 0.0000981
GlcNAcstatin C
0.00000074
GlcNAcstatin D
-
-
0.0085
GlcNAcstatin E
-
-
0.0000163 - 0.0000214
GlcNAcstatin G
0.0062
N-((1R,2R,5S,6R)-2-amino-5,6-dihydroxycyclohex-3-enyl)acetamide
-
-
0.011
N-((3R,4R,5R,6S)-3,5,6-trihydroxy-7-(hydroxymethyl)azepan-4-yl)acetamide
-
-
0.0024
N-((3S,4R,5R,Z)-4,5-dihydroxy-6-(hydroxymethyl)-2-(phenylcarbamoyloxyimino)tetrahydro-2H-pyran-3-yl)butyramide
-
-
0.000004
N-((6S,7R,8R)-6,7-dihydroxy-5-(hydroxymethyl)-2-phenethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-yl)isobutyramide
-
-
3.9
N-acetyl-D-glucosamine
-
-
0.0016
N-acetylglucosamino-1,5-lactone oxime
-
-
0.00008
NAG-thiazoline
-
-
0.000035 - 0.000046
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate
0.00005
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenyl carbamate
-
-
0.0000054 - 0.000052
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate
0.0024
O-(2-deoxy-2-butamido-D-glucopyranosylidene)amino N-phenylcarbamate
-
-
0.21
O-(2-deoxy-2-hexamido-D-glucopyranosylidene)amino N-phenylcarbamate
-
-
0.009
O-(2-deoxy-2-isobutamido-D-glucopyranosylidene)amino N-phenylcarbamate
-
-
0.19
O-(2-deoxy-2-isovaleramido-D-glucopyranosylidene)amino N-phenylcarbamate
-
-
0.0012
O-(2-deoxy-2-propamido-D-glucopyranosylidene)amino N-phenylcarbamate
-
-
0.04
O-(2-deoxy-2-valeramido-D-glucopyranosylidene)amino N-phenylcarbamate
-
-
0.00000008 - 0.009
thiamet G
0.0006
(3aS,5R,6S,7R,7aR)-5-(hydroxymethyl)-2-propyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
-
OGA-FL
0.0015
(3aS,5R,6S,7R,7aR)-5-(hydroxymethyl)-2-propyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
-
OGA-NV
0.00007
1,2-dideoxy-2'-methyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
-
0.00018
1,2-dideoxy-2'-methyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
at pH 7.4, using 4-nitrophenyl N-acetyl-beta-D-glucosaminide as a substrat
0.00023
1,2-dideoxy-2'-propyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
-
0.0006
1,2-dideoxy-2'-propyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline
-
-
0.00000042
GlcNAcstatin B
-
-
0.0000232
GlcNAcstatin B
pH and temperature not specified in the publication
0.000066
GlcNAcstatin B
pH and temperature not specified in the publication
0.0000044
GlcNAcstatin C
-
-
0.0000046
GlcNAcstatin C
wild-type
0.000074
GlcNAcstatin C
W490A mutant
0.0000981
GlcNAcstatin C
V331C mutant
0.0000163
GlcNAcstatin G
pH and temperature not specified in the publication
0.0000214
GlcNAcstatin G
pH and temperature not specified in the publication
0.000035
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate
-
-
0.000046
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate
-
-
0.0000054
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate
-
0.000046
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate
-
-
0.000052
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate
-
-
0.0000066
PUGNAc
truncated enzyme OGA57-400/544-705, pH and temperature not specified in the publication
0.0000123
PUGNAc
truncated enzyme OGA14-400/554-705, pH and temperature not specified in the publication
0.00004
PUGNAc
full-length enzyme, pH and temperature not specified in the publication
0.00059
PUGNAc
truncated enzyme OGA1-662, pH and temperature not specified in the publication
0.011
PUGNAc
truncated enzyme OGA14-400, pH and temperature not specified in the publication
0.06
PUGNAc
truncated enzyme OGA14-341, pH and temperature not specified in the publication
1.5
streptozotocin
-
-
1.5
streptozotocin
-
poor inhibitor
0.00000008
thiamet G
truncated enzyme OGA57-400/544-705, pH and temperature not specified in the publication
0.00000025
thiamet G
full-length enzyme, pH and temperature not specified in the publication
0.00000043
thiamet G
truncated enzyme OGA14-400/554-705, pH and temperature not specified in the publication
0.0000058
thiamet G
truncated enzyme OGA1-662, pH and temperature not specified in the publication
0.000037
thiamet G
pH and temperature not specified in the publication
0.0001531
thiamet G
pH and temperature not specified in the publication
0.0031
thiamet G
truncated enzyme OGA14-400, pH and temperature not specified in the publication
0.009
thiamet G
truncated enzyme OGA14-341, pH and temperature not specified in the publication
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Ngoh, G.A.; Facundo, H.T.; Hamid, T.; Dillmann, W.; Zachara, N.E.; Jones, S.P.
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Rattus norvegicus
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Homo sapiens, Clostridium perfringens (Q0TR53)
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2006
Homo sapiens
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Mus musculus (Q9EQQ9)
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Homo sapiens
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Homo sapiens
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Bacteroides thetaiotaomicron (Q89ZI2), Bacteroides thetaiotaomicron
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Homo sapiens
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Homo sapiens
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Bacteroides thetaiotaomicron (Q89ZI2)
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Chlorocebus aethiops, Bos taurus, Cricetulus griseus, Homo sapiens
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Bacteroides thetaiotaomicron (Q89ZI2)
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Homo sapiens
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Rattus norvegicus
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Rattus norvegicus
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Homo sapiens (O60502), Homo sapiens, Clostridium perfringens (Q0TR53), Clostridium perfringens
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Clostridium perfringens
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Homo sapiens (O60502)
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Corynebacterium pseudotuberculosis, Corynebacterium pseudotuberculosis DSM-20689
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Keembiyehetty, C.; Love, D.C.; Harwood, K.R.; Gavrilova, O.; Comly, M.E.; Hanover, J.A.
Conditional knock-out reveals a requirement for O-linked N-acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis
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Mus musculus (Q9EQQ9), Mus musculus
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Akan, I.; Love, D.C.; Harwood, K.R.; Bond, M.R.; Hanover, J.A.
Drosophila O-GlcNAcase deletion globally perturbs chromatin O-GlcNAcylation
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Drosophila melanogaster
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Elsen, N.L.; Patel, S.B.; Ford, R.E.; Hall, D.L.; Hess, F.; Kandula, H.; Kornienko, M.; Reid, J.; Selnick, H.; Shipman, J.M.; Sharma, S.; Lumb, K.J.; Soisson, S.M.; Klein, D.J.
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Homo sapiens (O60502), Homo sapiens
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Drosophila melanogaster
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666
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Homo sapiens (O60502)
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