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Information on EC 3.2.1.114 - mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

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IUBMB Comments
The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. It removes two mannosyl residues, one linked by alpha1,3 linkage, and the other linked by alpha1,6 linkage, both of which are removed by the same catalytic site. The enzyme is sensitive to swainsonine.
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This record set is specific for:
UNIPROT: Q99YP5
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
mannosidase ii, jack bean alpha-mannosidase, man2a1, alpha-mannosidase iix, dgmii, manii, alpha-mii, drosophila gmii, alpha-d-mannosidase ii, afams1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alpha-D-mannosidase II
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alpha-mannosidase II
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alpha-mannosidase III
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alpha1-3,6-mannosidase
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exo-1,3-1,6-alpha-mannosidase
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GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase
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Golgi alpha-mannosidase II
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Man II
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MAN IIx
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ManIII
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mannosidase II
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mannosidase, exo-1,3-1,6-alpha-
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mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of O-glycosyl bond
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
(1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase (configuration-retaining)
The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. It removes two mannosyl residues, one linked by alpha1,3 linkage, and the other linked by alpha1,6 linkage, both of which are removed by the same catalytic site. The enzyme is sensitive to swainsonine.
CAS REGISTRY NUMBER
COMMENTARY hide
349553-33-9
alpha-mannosidase III
82047-77-6
alpha-mannosidase II
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.01
2,4-dinitrophenyl alpha-D-mannopyranoside
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pH 6.8, 37°C, recombinant enzyme
0.24
3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose
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pH 6.8, 37°C, recombinant enzyme
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene M1 GAS SF370
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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the enzyme is perhaps functioning in the subsequent degradation of extracellular host glycans following their initial digestion by secreted glycosidases
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q99YP5_STRP1
901
0
102751
TrEMBL
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