Reference on EC 3.2.1.108 - lactase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Day, A.J.; Canada, F.J.; Diaz, J.C.; Kroon, P.A.; Mclauchlan, R.; Faulds, C.B.; Plumb, G.W.; Morgan, M.R.A.; Williamson, G.
Dietary flavonoids and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase
FEBS Lett.
468
166-170
2000
Ovis aries
Jacob, R.; Weiner, J.R.; Stadge, S.; Naim, H.Y.
Additional N-glycosylation and its impact on the folding of intestinal lactase-phlorizin hydrolase
J. Biol. Chem.
275
10630-10637
2000
Homo sapiens
Skovbjerg, H.; Sjstrm, H.; Noren, O.
Purification and characterization of amphiphilic lactase/phlorizin hydrolase from human small intestine
Eur. J. Biochem.
114
653-661
1981
Homo sapiens
Skovbjerg, H.; Noren, O.; Sjstrm, H.; Danielsen, E.M.; Enevoldsen, B.S.
Further characterization of intestinal lactase/phlorizin hydrolase
Biochim. Biophys. Acta
707
89-97
1982
Homo sapiens, Sus scrofa
Ramaswamy, S.; Radhakrishnan, A.N.
Lactase-phlorizin hydrolase complex from monkey small intestine. Purification, properties and evidence for two catalytic sites
Biochim. Biophys. Acta
403
446-455
1975
Platyrrhini
Schlegel-Haueter, S.; Hore, P.; Kerry, K.R.; Semenza, G.
The preparation of lactase and glucoamylase of rat small intestine
Biochim. Biophys. Acta
258
506-519
1972
Homo sapiens, Rattus norvegicus
Bueller, H.A.; Kothe, M.J.C.; Goldman, D.A.; Grubman, S.A.; Sasak, W.V.; Matsudaira, P.T.; Montgomery, R.K.; Grand, R.J.
Coordinate expression of lactate-phlorizin hydrolase mRNA and enzyme levels in rat intestine during development
J. Biol. Chem.
265
6978-6953
1990
Rattus norvegicus
Day, A.J.; Gee, J.M.; DuPont, M.S.; Johnson, I.T.; Williamson, G.
Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter
Biochem. Pharmacol.
65
1199-1206
2003
Rattus norvegicus
Jacob, R.; Peters, K.; Naim, H.Y.
Prosequence of human lactase-phlorizin hydrolase modulates the folding of mature enzyme
J. Biol. Chem.
277
8217-8225
2002
Homo sapiens
Burrin, D.G.; Stoll, B.; Fan, M.Z.; Dudley, M.A.; Donovan, S.M.; Reeds, P.J.
Oral IGF-I alters the posttranslational processing but not the activity of lactase-phlorizin hydrolase in formula-fed neonatal pigs
J. Nutr.
131
2235-2241
2001
Sus scrofa
Wilkinson, A.P.; Gee, J.M.; Dupont, M.S.; Needs, P.W.; Mellon, F.A.; Williamson, G.; Johnson, I.T.
Hydrolysis by lactase phlorizin hydrolase is the first step in the uptake of daidzein glucosides by rat small intestine in vitro
Xenobiotica
33
255-264
2003
Rattus norvegicus
West, A.R.; Oates, P.S.
Decreased sucrase and lactase activity in iron deficiency is accompanied by reduced gene expression and upregulation of the transcriptional repressor PDX-1
Am. J. Physiol. Gastronintest. Liver Physiol.
289
G1108-G1114
2005
Rattus norvegicus
Hermida, C.; Corrales, G.; Martinez-Costa, O.H.; Fernandez-Mayoralas, A.; Aragon, J.J.
Noninvasive evaluation of intestinal lactase with 4-galactosylxylose: comparison with 3- and 2-galactosylxylose and optimization of the method in rats
Clin. Chem.
52
270-277
2006
Rattus norvegicus
Lewinsky, R.H.; Jensen, T.G.; M?ller, J.; Stensballe, A.; Olsen, J.; Troelsen, J.T.
T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro
Hum. Mol. Genet.
14
3945-3953
2005
Homo sapiens
Kuranuki, S.; Mochizuki, K.; Goda, T.
Dietary sucrose enhances intestinal lactase gene expression in euthyroid rats
J. Nutr. Sci. Vitaminol.
52
347-351
2006
Rattus norvegicus
Beau, I.; Cotte-Laffitte, J.; Geniteau-Legendre, M.; Estes, M.K.; Servin, A.L.
An NSP4-dependant mechanism by which rotavirus impairs lactase enzymatic activity in brush border of human enterocyte-like Caco-2 cells
Cell. Microbiol.
9
2254-2266
2007
Homo sapiens
Kuokkanen, M.; Kokkonen, J.; Enattah, N.S.; Ylisaukko-Oja, T.; Komu, H.; Varilo, T.; Peltonen, L.; Savilahti, E.; Jarvela, I.
Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency
Am. J. Hum. Genet.
78
339-344
2006
Homo sapiens
He, W.; Ji, Z.Y.; Huang, C.Y.
Molecular cloning of a novel cDNA from Mus muscular BALB/c mice encoding glycosyl hydrolase family 1: a homolog of human lactase-phlorizin hydrolase
Biomed. Environ. Sci.
19
340-345
2006
Mus musculus, Mus musculus BALB/c
Hermida, C.; Corrales, G.; Canada, F.J.; Aragon, J.J.; Fernandez-Mayoralas, A.
Optimizing the enzymatic synthesis of beta-D-galactopyranosyl-D-xyloses for their use in the evaluation of lactase activity in vivo
Bioorg. Med. Chem.
15
4836-4840
2007
Rattus norvegicus
Bernardes-Silva Carlos Felip, B.C.; Pereira Alexandre , P.A.; de Fatima Alves da Mota Glori, d.F.; Krieger Jose Eduard, K.J.; Laudanna Antonio Atili, L.A.
Lactase persistence/non-persistence variants, C/T_13910 and G/A_22018, as a diagnostic tool for lactose intolerance in IBS patients
Clin. Chim. Acta
386
7-11
2007
Homo sapiens
Tamura, A.; Shiomi, T.; Hachiya, S.; Shigematsu, N.; Hara, H.
Low activities of intestinal lactase suppress the early phase absorption of soy isoflavones in Japanese adults
Clin. Nutr.
27
248-253
2008
Homo sapiens
Imtiaz , I.F.; Savilahti , S.E.; Sarnesto , S.A.; Trabzuni , T.D.; Al-Kahtani , A.K.; Kagevi , K.I.; Rashed M. , R.M.; Meyer B. , M.B.; Jarvela , J.I.
The T/G 13915 variant upstream of the lactase gene (LCT) is the founder allele of lactase persistence in an urban Saudi population
J. Med. Genet.
44
e89-e89
2007
Homo sapiens
Chaudhry, K.K.; Mahmood, S.; Mahmood, A.
Hormone induced expression of brush border lactase in suckling rat intestine
Mol. Cell. Biochem.
312
11-16
2008
Rattus norvegicus
Torniainen, S.; Freddara, R.; Routi, T.; Gijsbers, C.; Catassi, C.; Hoeglund, P.; Savilahti, E.; Jaervelae, I.
Four novel mutations in the lactase gene (LCT) underlying congenital lactase deficiency (CLD)
BMC Gastroenterol.
9
8
2009
Homo sapiens (P09848), Homo sapiens
Karas-Kuzelicki, N.; Pfeifer, V.; Lukac-Bajalo, J.
Synergistic effect of high lactase activity genotype and galactose-1-phosphate uridyl transferase (GALT) mutations on idiopathic presenile cataract formation
Clin. Biochem.
41
869-874
2008
Homo sapiens
Behrendt, M.; Keiser, M.; Hoch, M.; Naim, H.Y.
Impaired trafficking and subcellular localization of a mutant lactase associated with congenital lactase deficiency
Gastroenterology
136
2295-2303
2009
Homo sapiens
Fabre, J.W.; Salehi, S.; Eckley, L.; Sawyer, G.J.; Zhang, X.; Dong, X.; Freund, J.N.
Intestinal lactase as an autologous beta-galactosidase reporter gene for in vivo gene expression studies
Hum. Gene Ther.
20
21-30
2008
Escherichia coli, Rattus norvegicus
Willing, B.P.; Van Kessel, A.G.
Intestinal microbiota differentially affect brush border enzyme activity and gene expression in the neonatal gnotobiotic pig
J. Anim. Physiol. Anim. Nutr. (Berl.)
93
586-595
2008
Sus scrofa (Q29587)
Tanaka, T.; Suzuki, A.; Kuranuki, S.; Mochizuki, K.; Suruga, K.; Takase, S.; Goda, T.
Higher expression of jejunal LPH gene in rats fed the high-carbohydrate/low-fat diet compared with those fed the low-carbohydrate/high-fat diet is associated with in vitro binding of Cdx-2 in nuclear proteins to its promoter regions
Life Sci.
83
122-127
2008
Rattus norvegicus
Chaudhry, K.K.; Mahmood, S.; Mahmood, A.
Hormone induced changes in lactase glycosylation in developing rat intestine
Mol. Cell. Biochem.
318
183-190
2008
Rattus norvegicus
Khabarova, Y.A.; Torniainen, S.T.; Nurmi, H.A.; Jaervelae, I.E.; Isokoski, M.K.; Mattila, K.J.
Prevalence of lactase persistent/non-persistent genotypes and milk consumption in a young population in north-west Russia
World J. Gastroenterol.
15
1849-1853
2009
Homo sapiens
Koek, W.; van Meurs, J.; van der Eerden, B.; Rivadeneira, F.; Zillikens, M.; Hofman, A.; Obermayer-Pietsch, B.; Lips, P.; Pols, H.; Uitterlinden, A.; van Leeuwen, J.
The T-13910C polymorphism in the lactase phlorizin hydrolase gene is associated with differences in serum calcium levels and calcium intake
J. Bone Miner. Res.
25
1980-1987
2010
Homo sapiens
Ingram, C.J.; Raga, T.O.; Tarekegn, A.; Browning, S.L.; Elamin, M.F.; Bekele, E.; Thomas, M.G.; Weale, M.E.; Bradman, N.; Swallow, D.M.
Multiple rare variants as a cause of a common phenotype: several different lactase persistence associated alleles in a single ethnic group
J. Mol. Evol.
69
579-588
2009
Homo sapiens
Khabarova, Y.; Torniainen, S.; Savilahti, E.; Isokoski, M.; Mattila, K.; Jaervelae, I.
The -13914G>A variant upstream of the lactase gene (LCT) is associated with lactase persistence/non-persistence
Scand. J. Clin. Lab. Invest.
70
354-357
2010
Homo sapiens
Kuchay, R.A.; Thapa, B.R.; Mahmood, A.; Mahmood, S.
Effect of C/T -13910 cis-acting regulatory variant on expression and activity of lactase in Indian children and its implication for early genetic screening of adult-type hypolactasia
Clin. Chim. Acta
412
1924-1930
2011
Homo sapiens
Naz, S.; Siddiqi, R.; Dew, T.P.; Williamson, G.
Epigallocatechin-3-gallate inhibits lactase but is alleviated by salivary proline-rich proteins
J. Agric. Food Chem.
59
2734-2738
2011
Rattus norvegicus
Zhou, J.; Chen, Y.; Wang, Y.; Gao, X.; Qu, D.; Liu, C.
A comparative study on the metabolism of Epimedium koreanum nakai-prenylated flavonoids in rats by an intestinal enzyme (lactase phlorizin hydrolase) and intestinal flora
Molecules
19
177-203
2014
Rattus norvegicus
Zou, S.; He, X.; Liu, Y.; Chen, D.; Luo, Y.; Huang, K.; Zhang, W.; Xu, W.
Toxicological evaluation of lactase derived from recombinant Pichia pastoris
PLoS ONE
9
e106470
2014
Aspergillus oryzae
Diekmann, L.; Behrendt, M.; Amiri, M.; Naim, H.Y.
Structural determinants for transport of lactase phlorizin-hydrolase in the early secretory pathway as a multi-domain membrane glycoprotein
Biochim. Biophys. Acta
1861
3119-3128
2017
Homo sapiens (P09848)
Suzuki, T.; Mochizuki, K.; Goda, T.
Thyroid and glucocorticoid hormones induce expression of lactase-phlorizin hydrolase gene in CDX-2/HNF-1alpha co-transfected IEC-6 cells
J. Nutr. Sci. Vitaminol.
60
321-327
2015
Rattus norvegicus (Q02401)
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